LEPROTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01403158
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86470123
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.86470123
4negative regulation of cell killing (GO:0031342)4.81677862
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.81677862
6positive regulation of gamma-delta T cell activation (GO:0046645)4.70985707
7regulation of isotype switching to IgG isotypes (GO:0048302)4.69280963
8negative T cell selection (GO:0043383)4.54730614
9negative thymic T cell selection (GO:0045060)4.42773602
10sequestering of actin monomers (GO:0042989)4.41309878
11interferon-gamma production (GO:0032609)4.38005866
12leukocyte aggregation (GO:0070486)4.34919910
13response to interleukin-15 (GO:0070672)4.24292300
14DNA deamination (GO:0045006)4.21827175
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19742657
16antigen processing and presentation of endogenous antigen (GO:0019883)4.17639566
17cellular response to interleukin-15 (GO:0071350)4.09471894
18mast cell activation (GO:0045576)4.02991601
19protein-cofactor linkage (GO:0018065)3.91456158
20pyrimidine nucleobase catabolic process (GO:0006208)3.84519876
21signal peptide processing (GO:0006465)3.80288345
22regulation of T cell tolerance induction (GO:0002664)3.78309675
23neural tube formation (GO:0001841)3.77865751
24positive thymic T cell selection (GO:0045059)3.74673861
25positive T cell selection (GO:0043368)3.70665492
26T cell migration (GO:0072678)3.63481083
27T cell receptor signaling pathway (GO:0050852)3.51590835
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50772096
29thymic T cell selection (GO:0045061)3.49795492
30T cell costimulation (GO:0031295)3.44597929
31lymphocyte costimulation (GO:0031294)3.44536577
32T cell selection (GO:0045058)3.41076508
33regulation of defense response to virus by virus (GO:0050690)3.40819144
34regulation of gamma-delta T cell differentiation (GO:0045586)3.35492215
35mast cell degranulation (GO:0043303)3.30340034
36mast cell activation involved in immune response (GO:0002279)3.30340034
37activated T cell proliferation (GO:0050798)3.27841577
38Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27365751
39gamma-aminobutyric acid transport (GO:0015812)3.26386217
40cellular response to type I interferon (GO:0071357)3.26354436
41type I interferon signaling pathway (GO:0060337)3.26354436
42regulation of B cell receptor signaling pathway (GO:0050855)3.24312523
43response to type I interferon (GO:0034340)3.23185831
44protein neddylation (GO:0045116)3.17082714
45positive regulation of mitochondrial fission (GO:0090141)3.15771357
46regulation of T cell receptor signaling pathway (GO:0050856)3.14576820
47antigen receptor-mediated signaling pathway (GO:0050851)3.14070539
48positive regulation of macrophage differentiation (GO:0045651)3.13474799
49positive regulation of T cell differentiation in thymus (GO:0033089)3.13161599
50fucose catabolic process (GO:0019317)3.12054611
51L-fucose metabolic process (GO:0042354)3.12054611
52L-fucose catabolic process (GO:0042355)3.12054611
53regulation of natural killer cell mediated immunity (GO:0002715)3.10965356
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10965356
55positive regulation of tolerance induction (GO:0002645)3.09063844
56regulation of gamma-delta T cell activation (GO:0046643)3.07683537
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07449824
58positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.07295855
59positive regulation of natural killer cell mediated immunity (GO:0002717)3.07295855
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07109694
61regulation of tolerance induction (GO:0002643)3.06776632
62antigen processing and presentation via MHC class Ib (GO:0002475)3.06708633
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05183989
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02944153
65mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.01364894
66positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.01364894
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00930432
68interferon-gamma-mediated signaling pathway (GO:0060333)3.00381671
69nucleobase catabolic process (GO:0046113)2.97373101
70behavioral response to nicotine (GO:0035095)2.96493964
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95686224
72positive regulation of granulocyte differentiation (GO:0030854)2.92395753
73leukocyte degranulation (GO:0043299)2.91579053
74regulation of alpha-beta T cell proliferation (GO:0046640)2.88540384
75regulation of regulatory T cell differentiation (GO:0045589)2.84418882
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82921246
77regulation of leukocyte mediated cytotoxicity (GO:0001910)2.80701458
78respiratory chain complex IV assembly (GO:0008535)2.80287453
79negative regulation of T cell mediated immunity (GO:0002710)2.79392763
80protein deneddylation (GO:0000338)2.75761888
81leukocyte cell-cell adhesion (GO:0007159)2.74532142
82negative regulation of telomere maintenance (GO:0032205)2.70934910
83negative regulation of calcium ion transport into cytosol (GO:0010523)2.70452940
84neuron cell-cell adhesion (GO:0007158)2.69754706
85nonmotile primary cilium assembly (GO:0035058)2.69397477
86cullin deneddylation (GO:0010388)2.69252996
87regulation of cilium movement (GO:0003352)2.68791244
88positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.68255864
89respiratory burst (GO:0045730)2.67785879
90barbed-end actin filament capping (GO:0051016)2.67511458
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66918835
92natural killer cell activation (GO:0030101)2.66752506
93negative regulation of T cell receptor signaling pathway (GO:0050860)2.66455366
94preassembly of GPI anchor in ER membrane (GO:0016254)2.64940994
95positive regulation of interleukin-2 production (GO:0032743)2.64496449
96protein complex biogenesis (GO:0070271)2.64351039
97alpha-beta T cell differentiation (GO:0046632)2.63927491
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63283671
99regulation of mitotic spindle checkpoint (GO:1903504)2.63283671
100T cell differentiation (GO:0030217)2.62714322
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62702659
102regulation of T cell mediated cytotoxicity (GO:0001914)2.62511333
103cellular response to interferon-beta (GO:0035458)2.62160562
104protein prenylation (GO:0018342)2.61571704
105prenylation (GO:0097354)2.61571704
106T cell proliferation (GO:0042098)2.61485972
107regulation of cell killing (GO:0031341)2.60920317
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60318866
109tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60318866
110negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.60164774
111heterotypic cell-cell adhesion (GO:0034113)2.59820964
112cellular defense response (GO:0006968)2.59603089
113rRNA catabolic process (GO:0016075)2.58555915
114positive regulation of mRNA catabolic process (GO:0061014)2.58248660
115sulfation (GO:0051923)2.57232918
116positive regulation of oligodendrocyte differentiation (GO:0048714)2.56902389
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.56828899
118NADH dehydrogenase complex assembly (GO:0010257)2.56828899
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56828899
120regulation of interleukin-2 biosynthetic process (GO:0045076)2.56746108
121platelet dense granule organization (GO:0060155)2.56329267
122forebrain neuron differentiation (GO:0021879)2.56017837
123regulation of B cell differentiation (GO:0045577)2.55973064
124regulation of isotype switching (GO:0045191)2.54923867
125negative regulation of type 2 immune response (GO:0002829)2.54073684
126actin nucleation (GO:0045010)2.53627125
127myeloid dendritic cell activation (GO:0001773)2.52895214
128GPI anchor metabolic process (GO:0006505)2.52702796
129neutrophil activation involved in immune response (GO:0002283)2.52678930
130regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.51629927
131positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.51629927
132protein localization to cilium (GO:0061512)2.50810367
133regulation of chronic inflammatory response (GO:0002676)2.48698699
134positive regulation of interferon-gamma production (GO:0032729)2.48531447
135iron-sulfur cluster assembly (GO:0016226)2.48006226
136metallo-sulfur cluster assembly (GO:0031163)2.48006226
137lymphocyte migration (GO:0072676)2.47882719
138T cell homeostasis (GO:0043029)2.47693043
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.47616865
140positive regulation of cell killing (GO:0031343)2.47245575
141positive regulation of isotype switching (GO:0045830)2.46862316
142positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.46183754
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45264897
144regulation of response to interferon-gamma (GO:0060330)2.44299400
145tolerance induction (GO:0002507)2.43907306
146synaptic vesicle maturation (GO:0016188)2.43892370
147cytochrome complex assembly (GO:0017004)2.43717622
148positive regulation of lamellipodium assembly (GO:0010592)2.42683668
149indolalkylamine metabolic process (GO:0006586)2.42659943
150immune response-activating cell surface receptor signaling pathway (GO:0002429)2.42642972
151mitochondrial respiratory chain complex assembly (GO:0033108)2.40165674
152positive regulation of T cell mediated cytotoxicity (GO:0001916)2.40011652
153regulation of immunoglobulin mediated immune response (GO:0002889)2.39683709
154DNA damage response, detection of DNA damage (GO:0042769)2.39579268
155positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.38506070
156regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.38506070
157alpha-beta T cell activation (GO:0046631)2.38149177
158response to protozoan (GO:0001562)2.36971033
159regulation of B cell mediated immunity (GO:0002712)2.36915651
160adaptation of signaling pathway (GO:0023058)2.36811884
161defense response to protozoan (GO:0042832)2.35706935
162adenosine metabolic process (GO:0046085)2.35644320
163T cell activation (GO:0042110)2.35493862
164establishment of protein localization to Golgi (GO:0072600)2.34976378
165ubiquinone metabolic process (GO:0006743)2.34225293
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33530795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.86302594
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.98124683
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.64465375
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.26907651
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.76360640
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.73876623
7ZNF274_21170338_ChIP-Seq_K562_Hela3.33988674
8RUNX_20019798_ChIP-Seq_JUKART_Human3.33778506
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24670224
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.12167620
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.06320386
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85954194
13IGF1R_20145208_ChIP-Seq_DFB_Human2.79337709
14* MYB_26560356_Chip-Seq_TH2_Human2.72180208
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.72101179
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67532503
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.66176517
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65607428
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60405413
20VDR_22108803_ChIP-Seq_LS180_Human2.52773494
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.48111478
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46688863
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46554666
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.43855971
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.35379101
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34492891
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33988849
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33911223
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29880211
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27755382
31GBX2_23144817_ChIP-Seq_PC3_Human2.24435790
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24033929
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22903964
34TAF15_26573619_Chip-Seq_HEK293_Human2.21733060
35MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21054746
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.18733670
37SMAD_19615063_ChIP-ChIP_OVARY_Human2.18445198
38* MAF_26560356_Chip-Seq_TH1_Human2.16501823
39SPI1_23547873_ChIP-Seq_NB4_Human2.07672174
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06475425
41FUS_26573619_Chip-Seq_HEK293_Human2.02044317
42PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01325507
43EWS_26573619_Chip-Seq_HEK293_Human2.00533379
44MYB_26560356_Chip-Seq_TH1_Human1.96977578
45* GATA3_27048872_Chip-Seq_THYMUS_Human1.95833024
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90428649
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.88987168
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88179894
49* UTX_26944678_Chip-Seq_JUKART_Human1.86016260
50SPI1_23127762_ChIP-Seq_K562_Human1.83445337
51IRF1_19129219_ChIP-ChIP_H3396_Human1.81863046
52P300_19829295_ChIP-Seq_ESCs_Human1.80701330
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78755218
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76529988
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75828247
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66451385
57FOXP3_21729870_ChIP-Seq_TREG_Human1.64794950
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62988214
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61863811
60VDR_24763502_ChIP-Seq_THP-1_Human1.61631327
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59496681
62SCL_19346495_ChIP-Seq_HPC-7_Human1.58264516
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54158788
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.51926183
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51673090
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50172580
67MAF_26560356_Chip-Seq_TH2_Human1.48736033
68ER_23166858_ChIP-Seq_MCF-7_Human1.46534778
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46050114
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44912344
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.44633692
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43883284
73MYC_18940864_ChIP-ChIP_HL60_Human1.43807153
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42789967
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.40588251
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38303025
77EZH2_22144423_ChIP-Seq_EOC_Human1.38216800
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37934681
79GATA3_26560356_Chip-Seq_TH2_Human1.37577943
80TP53_22573176_ChIP-Seq_HFKS_Human1.37116599
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35175769
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34964552
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34687886
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.34461496
85PU_27001747_Chip-Seq_BMDM_Mouse1.33557525
86* GABP_17652178_ChIP-ChIP_JURKAT_Human1.32443266
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31248309
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.30696952
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30532925
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.28148158
91VDR_21846776_ChIP-Seq_THP-1_Human1.26277479
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25652866
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25371082
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25319489
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23080604
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22314581
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22027466
98CBP_20019798_ChIP-Seq_JUKART_Human1.22027466
99SOX2_19829295_ChIP-Seq_ESCs_Human1.21113558
100NANOG_19829295_ChIP-Seq_ESCs_Human1.21113558
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19108745
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18250665
103CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17535289
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16660953
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16057787
106MYC_22102868_ChIP-Seq_BL_Human1.15845722
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15260354
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.15229168
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14004445
110P53_22387025_ChIP-Seq_ESCs_Mouse1.13210102
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12439416
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12124004
113BCAT_22108803_ChIP-Seq_LS180_Human1.11131078
114* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11053222
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10726549
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.10498552
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09560872
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09255932
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09239331
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08906751
121* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08491907
122GATA1_22025678_ChIP-Seq_K562_Human1.08111119
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07946816
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07844812
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07141419
126SMAD4_21799915_ChIP-Seq_A2780_Human1.06730486
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06563523
128* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05874094
129* FOXA1_25329375_ChIP-Seq_VCAP_Human1.05874094
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05763189
131* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05590706
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.04375334
133STAT3_23295773_ChIP-Seq_U87_Human1.03907338
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.03715200
135GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03166634
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03144891
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01979000
138OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01553046
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.01458599
140CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01406773
141POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00621081
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00088692
143AR_25329375_ChIP-Seq_VCAP_Human0.99831598
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.99035909
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98688743
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.98476580
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97604229
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96922899
149E2F1_18555785_Chip-Seq_ESCs_Mouse0.96825410
150* VDR_23849224_ChIP-Seq_CD4+_Human0.96553633
151RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96109648
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95957189
153GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95614366
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95323135
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94803613
156* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92641928
157ELK1_19687146_ChIP-ChIP_HELA_Human0.91280481
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89007421
159EGR1_19032775_ChIP-ChIP_M12_Human0.88557645
160* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87994192
161TCF7_22412390_ChIP-Seq_EML_Mouse0.87416259
162GATA2_21666600_ChIP-Seq_HMVEC_Human0.87233712
163WT1_19549856_ChIP-ChIP_CCG9911_Human0.86746285
164GATA1_19941827_ChIP-Seq_MEL_Mouse0.84560448
165HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81946524
166* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81919985
167SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81173394
168KDM2B_26808549_Chip-Seq_DND41_Human0.81027229
169KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79475858
170ELK1_22589737_ChIP-Seq_MCF10A_Human0.76191314
171FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76110637
172THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75618409
173RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75328382
174Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73467882
175KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71573513
176CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.71277369
177SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70525255
178PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69053607
179ETS1_22383799_ChIP-Seq_G1ME_Mouse0.67922598
180DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67301256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.01053058
2MP0003763_abnormal_thymus_physiology3.32472078
3MP0001835_abnormal_antigen_presentation3.28770917
4MP0009785_altered_susceptibility_to2.95061377
5MP0008877_abnormal_DNA_methylation2.90359230
6MP0000685_abnormal_immune_system2.89884133
7MP0005000_abnormal_immune_tolerance2.72039505
8MP0003787_abnormal_imprinting2.61032998
9MP0001986_abnormal_taste_sensitivity2.49447464
10MP0003724_increased_susceptibility_to2.46129334
11MP0002102_abnormal_ear_morphology2.45388927
12MP0003436_decreased_susceptibility_to2.39305691
13MP0005387_immune_system_phenotype2.38004555
14MP0001790_abnormal_immune_system2.38004555
15MP0002148_abnormal_hypersensitivity_rea2.37454992
16MP0002723_abnormal_immune_serum2.36775545
17MP0002420_abnormal_adaptive_immunity2.36603848
18MP0001819_abnormal_immune_cell2.34386998
19MP0001800_abnormal_humoral_immune2.33202114
20MP0005025_abnormal_response_to2.30854144
21MP0001529_abnormal_vocalization2.28174081
22MP0002735_abnormal_chemical_nociception2.25825859
23MP0006082_CNS_inflammation2.24495267
24MP0009333_abnormal_splenocyte_physiolog2.14156900
25MP0002452_abnormal_antigen_presenting2.10342617
26MP0003866_abnormal_defecation2.07857587
27MP0001984_abnormal_olfaction2.03200978
28MP0002398_abnormal_bone_marrow2.00745742
29MP0002166_altered_tumor_susceptibility2.00202254
30MP0006072_abnormal_retinal_apoptosis1.98326089
31MP0001968_abnormal_touch/_nociception1.95682002
32MP0002419_abnormal_innate_immunity1.95647332
33MP0004142_abnormal_muscle_tone1.93602209
34MP0004510_myositis1.92317567
35MP0002277_abnormal_respiratory_mucosa1.90288031
36MP0005464_abnormal_platelet_physiology1.88454600
37MP0000716_abnormal_immune_system1.83654569
38MP0003183_abnormal_peptide_metabolism1.83579949
39MP0002405_respiratory_system_inflammati1.76515637
40MP0002163_abnormal_gland_morphology1.74625432
41MP0005253_abnormal_eye_physiology1.73125676
42MP0002653_abnormal_ependyma_morphology1.67984946
43MP0005310_abnormal_salivary_gland1.66122357
44MP0002006_tumorigenesis1.62659787
45MP0002736_abnormal_nociception_after1.58129857
46MP0010155_abnormal_intestine_physiology1.57371619
47MP0003011_delayed_dark_adaptation1.57123659
48MP0003300_gastrointestinal_ulcer1.55099909
49MP0000569_abnormal_digit_pigmentation1.54978635
50MP0004947_skin_inflammation1.54474967
51MP0000703_abnormal_thymus_morphology1.52733982
52MP0002877_abnormal_melanocyte_morpholog1.49735774
53MP0005551_abnormal_eye_electrophysiolog1.48794197
54MP0002722_abnormal_immune_system1.48332580
55MP0001533_abnormal_skeleton_physiology1.47498050
56MP0001845_abnormal_inflammatory_respons1.47304911
57MP0008995_early_reproductive_senescence1.45879513
58MP0003172_abnormal_lysosome_physiology1.45567827
59MP0002429_abnormal_blood_cell1.44711136
60MP0002009_preneoplasia1.44056477
61MP0009046_muscle_twitch1.42322608
62MP0001970_abnormal_pain_threshold1.42190232
63MP0005174_abnormal_tail_pigmentation1.40715932
64MP0000689_abnormal_spleen_morphology1.40380381
65MP0003122_maternal_imprinting1.38512581
66MP0008058_abnormal_DNA_repair1.37885272
67MP0002733_abnormal_thermal_nociception1.37238175
68MP0002822_catalepsy1.37216179
69MP0004859_abnormal_synaptic_plasticity1.35983712
70MP0004270_analgesia1.35237457
71MP0000372_irregular_coat_pigmentation1.35026156
72MP0001873_stomach_inflammation1.34710448
73MP0003303_peritoneal_inflammation1.34574332
74MP0005058_abnormal_lysosome_morphology1.33411460
75MP0002933_joint_inflammation1.32171555
76MP0010386_abnormal_urinary_bladder1.32083564
77MP0003121_genomic_imprinting1.29598796
78MP0005084_abnormal_gallbladder_morpholo1.25774013
79MP0004133_heterotaxia1.25322077
80MP0008872_abnormal_physiological_respon1.25162207
81MP0006276_abnormal_autonomic_nervous1.24150635
82MP0003195_calcinosis1.23827626
83MP0002693_abnormal_pancreas_physiology1.22713945
84MP0002734_abnormal_mechanical_nocicepti1.22395846
85MP0001919_abnormal_reproductive_system1.20770653
86MP0002909_abnormal_adrenal_gland1.20586305
87MP0000858_altered_metastatic_potential1.17730139
88MP0001486_abnormal_startle_reflex1.16773437
89MP0002751_abnormal_autonomic_nervous1.16120430
90MP0008789_abnormal_olfactory_epithelium1.13037004
91MP0002557_abnormal_social/conspecific_i1.12810101
92MP0002396_abnormal_hematopoietic_system1.12643529
93MP0003635_abnormal_synaptic_transmissio1.11056108
94MP0000015_abnormal_ear_pigmentation1.08070715
95MP0005646_abnormal_pituitary_gland1.06858115
96MP0001905_abnormal_dopamine_level1.06431727
97MP0002928_abnormal_bile_duct1.05313170
98MP0004742_abnormal_vestibular_system1.03491121
99MP0003567_abnormal_fetal_cardiomyocyte1.02973163
100MP0008569_lethality_at_weaning1.02784149
101MP0003880_abnormal_central_pattern1.02080391
102MP0005075_abnormal_melanosome_morpholog1.01939690
103MP0002064_seizures1.01874896
104MP0000920_abnormal_myelination1.01404171
105MP0002638_abnormal_pupillary_reflex1.00444024
106MP0000013_abnormal_adipose_tissue1.00061461
107MP0001851_eye_inflammation1.00041417
108MP0005499_abnormal_olfactory_system0.99452745
109MP0005394_taste/olfaction_phenotype0.99452745
110MP0005645_abnormal_hypothalamus_physiol0.99329549
111MP0000631_abnormal_neuroendocrine_gland0.99072511
112MP0000465_gastrointestinal_hemorrhage0.96852642
113MP0004858_abnormal_nervous_system0.95670251
114MP0009764_decreased_sensitivity_to0.94925802
115MP0003136_yellow_coat_color0.94656590
116MP0009745_abnormal_behavioral_response0.94621197
117MP0008469_abnormal_protein_level0.94532624
118MP0004147_increased_porphyrin_level0.94461817
119MP0004885_abnormal_endolymph0.92442790
120MP0001764_abnormal_homeostasis0.92191778
121MP0004808_abnormal_hematopoietic_stem0.91804638
122MP0001188_hyperpigmentation0.90806106
123MP0005386_behavior/neurological_phenoty0.90309057
124MP0004924_abnormal_behavior0.90309057
125MP0001348_abnormal_lacrimal_gland0.89036961
126MP0002998_abnormal_bone_remodeling0.88981746
127MP0002272_abnormal_nervous_system0.88565832
128MP0009780_abnormal_chondrocyte_physiolo0.86225445
129MP0002063_abnormal_learning/memory/cond0.85508837
130MP0005389_reproductive_system_phenotype0.85251246
131MP0004043_abnormal_pH_regulation0.83151228
132MP0003786_premature_aging0.79558728
133MP0002876_abnormal_thyroid_physiology0.78814648
134MP0008875_abnormal_xenobiotic_pharmacok0.78449310
135MP0006035_abnormal_mitochondrial_morpho0.77920357
136MP0000343_altered_response_to0.77498758
137MP0004811_abnormal_neuron_physiology0.76374739
138MP0000778_abnormal_nervous_system0.75209949
139MP0001853_heart_inflammation0.74942561
140MP0001501_abnormal_sleep_pattern0.73153706
141MP0003221_abnormal_cardiomyocyte_apopto0.72720895
142MP0003075_altered_response_to0.71582346
143MP0003633_abnormal_nervous_system0.70451138
144MP0002095_abnormal_skin_pigmentation0.70159181
145MP0002067_abnormal_sensory_capabilities0.67843284
146MP0003329_amyloid_beta_deposits0.67525614
147MP0003448_altered_tumor_morphology0.67298394
148MP0001944_abnormal_pancreas_morphology0.66817764
149MP0002572_abnormal_emotion/affect_behav0.66770824
150MP0005379_endocrine/exocrine_gland_phen0.66760134
151MP0009379_abnormal_foot_pigmentation0.64628004
152MP0003045_fibrosis0.63549752

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.43661490
2Eczematoid dermatitis (HP:0000976)4.44970886
3T lymphocytopenia (HP:0005403)4.43417107
4Myositis (HP:0100614)4.32386847
5Recurrent abscess formation (HP:0002722)4.30559445
6Abnormality of T cell number (HP:0011839)4.23000990
7Medial flaring of the eyebrow (HP:0010747)3.69473844
8Stomatitis (HP:0010280)3.63256264
9Pancreatic cysts (HP:0001737)3.54536140
10IgM deficiency (HP:0002850)3.50154639
11Recurrent bacterial skin infections (HP:0005406)3.48022342
12Abnormality of T cells (HP:0002843)3.46465908
13Gait imbalance (HP:0002141)3.42842337
14Papilledema (HP:0001085)3.40849308
15Congenital primary aphakia (HP:0007707)3.40286348
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.36869959
17Recurrent bronchitis (HP:0002837)3.32408497
18Chronic otitis media (HP:0000389)3.30905965
19Nephrogenic diabetes insipidus (HP:0009806)3.26961273
20Increased cerebral lipofuscin (HP:0011813)3.21986255
21Hypothermia (HP:0002045)3.21960117
22Recurrent fungal infections (HP:0002841)3.19817197
23IgG deficiency (HP:0004315)3.11856569
24Increased IgM level (HP:0003496)3.08063702
25Chronic obstructive pulmonary disease (HP:0006510)3.07519156
26Obstructive lung disease (HP:0006536)3.07519156
27True hermaphroditism (HP:0010459)3.06850499
28Pancreatic fibrosis (HP:0100732)3.05803533
29Hypergammaglobulinemia (HP:0010702)2.91262330
30Nasal polyposis (HP:0100582)2.87878704
31Orchitis (HP:0100796)2.82075409
32Retrobulbar optic neuritis (HP:0100654)2.80956768
33Optic neuritis (HP:0100653)2.80956768
34Severe combined immunodeficiency (HP:0004430)2.77404396
35Abnormality of macrophages (HP:0004311)2.77345566
36Mediastinal lymphadenopathy (HP:0100721)2.76825069
37Abnormality of midbrain morphology (HP:0002418)2.76807692
38Molar tooth sign on MRI (HP:0002419)2.76807692
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.74988781
40Vacuolated lymphocytes (HP:0001922)2.74400961
41Recurrent skin infections (HP:0001581)2.72847233
42Chronic mucocutaneous candidiasis (HP:0002728)2.71808773
43Recurrent cutaneous fungal infections (HP:0011370)2.71808773
443-Methylglutaconic aciduria (HP:0003535)2.70399614
45Recurrent viral infections (HP:0004429)2.69892127
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.69357240
47Genital tract atresia (HP:0001827)2.65923052
48Vaginal atresia (HP:0000148)2.65807588
49Stomach cancer (HP:0012126)2.65472050
50Abnormality of T cell physiology (HP:0011840)2.63931909
51Meningitis (HP:0001287)2.62767560
52Amyotrophic lateral sclerosis (HP:0007354)2.60861784
53Abnormality of the nasal mucosa (HP:0000433)2.60491509
54Dysostosis multiplex (HP:0000943)2.58518503
55Progressive neurologic deterioration (HP:0002344)2.57458433
56Renal cortical cysts (HP:0000803)2.57159172
57Vasculitis (HP:0002633)2.53100676
58Abolished electroretinogram (ERG) (HP:0000550)2.51328825
59Abnormality of the renal cortex (HP:0011035)2.50527708
60Acute necrotizing encephalopathy (HP:0006965)2.49261783
61Interstitial pulmonary disease (HP:0006530)2.45019302
62Thrombocytosis (HP:0001894)2.44871628
63Petechiae (HP:0000967)2.43883147
64Abnormality of glycolipid metabolism (HP:0010969)2.42684907
65Abnormality of liposaccharide metabolism (HP:0010968)2.42684907
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.42684907
67Panhypogammaglobulinemia (HP:0003139)2.41217292
68Poor coordination (HP:0002370)2.40951058
69Congenital stationary night blindness (HP:0007642)2.40483002
70Abnormal biliary tract physiology (HP:0012439)2.39904619
71Bile duct proliferation (HP:0001408)2.39904619
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36733223
73Autoimmune hemolytic anemia (HP:0001890)2.36007599
74Abnormality of B cell number (HP:0010975)2.35226150
75B lymphocytopenia (HP:0010976)2.35226150
76Mitochondrial inheritance (HP:0001427)2.34506660
77Colon cancer (HP:0003003)2.33840222
78Abnormality of eosinophils (HP:0001879)2.33498514
79Visual hallucinations (HP:0002367)2.31633039
80Increased IgE level (HP:0003212)2.31119779
81Pulmonary infiltrates (HP:0002113)2.30710301
82Increased CSF lactate (HP:0002490)2.28397682
83Inability to walk (HP:0002540)2.28327604
84Neuroendocrine neoplasm (HP:0100634)2.27135568
85Nephronophthisis (HP:0000090)2.24799512
86Abnormality of alanine metabolism (HP:0010916)2.22357589
87Hyperalaninemia (HP:0003348)2.22357589
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22357589
89Progressive macrocephaly (HP:0004481)2.21316065
90Combined immunodeficiency (HP:0005387)2.20931551
91Diminished motivation (HP:0000745)2.20196016
92Lymphopenia (HP:0001888)2.19463690
93Mutism (HP:0002300)2.18737064
94Leukocytosis (HP:0001974)2.17437065
95Abnormal mitochondria in muscle tissue (HP:0008316)2.16308297
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14833285
97Supranuclear gaze palsy (HP:0000605)2.14451682
98Hemoptysis (HP:0002105)2.13212033
99Acute encephalopathy (HP:0006846)2.12736448
100Thyroiditis (HP:0100646)2.12217868
101Spinal canal stenosis (HP:0003416)2.11364559
102Agitation (HP:0000713)2.09456144
103Hypercortisolism (HP:0001578)2.08983855
104Spontaneous hematomas (HP:0007420)2.08368086
105Increased hepatocellular lipid droplets (HP:0006565)2.07265213
106Pheochromocytoma (HP:0002666)2.06293362
107Abnormality of the renal medulla (HP:0100957)2.05155568
108Lissencephaly (HP:0001339)2.04451727
109Attenuation of retinal blood vessels (HP:0007843)2.04104462
110Specific learning disability (HP:0001328)2.03091841
111Chronic diarrhea (HP:0002028)2.03002600
112Methylmalonic acidemia (HP:0002912)2.02798159
113Ankle clonus (HP:0011448)2.02245750
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.01752423
115Gingivitis (HP:0000230)2.01201243
116Myokymia (HP:0002411)2.00538185
117Eosinophilia (HP:0001880)1.98452709
118Hyperventilation (HP:0002883)1.98229840
119Apathy (HP:0000741)1.96285644
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96010773
121Abnormal protein N-linked glycosylation (HP:0012347)1.96010773
122Abnormal protein glycosylation (HP:0012346)1.96010773
123Abnormal glycosylation (HP:0012345)1.96010773
124Oligodactyly (hands) (HP:0001180)1.94160742
125Lipid accumulation in hepatocytes (HP:0006561)1.93875121
126Decreased testicular size (HP:0008734)1.91924293
127Type I transferrin isoform profile (HP:0003642)1.91733883
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.91349055
129Optic disc pallor (HP:0000543)1.91151358
130Basal ganglia calcification (HP:0002135)1.90855020
131Progressive cerebellar ataxia (HP:0002073)1.90833113
132Focal motor seizures (HP:0011153)1.90348886
133Intestinal atresia (HP:0011100)1.90321010
134Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89233342
135Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89233342
136Broad foot (HP:0001769)1.89007553
137Progressive inability to walk (HP:0002505)1.87856306
138Joint swelling (HP:0001386)1.86413462
139Bronchitis (HP:0012387)1.85953930
140Progressive microcephaly (HP:0000253)1.85657054
141Polyphagia (HP:0002591)1.83812194
142Chronic sinusitis (HP:0011109)1.83372961
143Encephalitis (HP:0002383)1.82666808
144Abnormality of calcium-phosphate metabolism (HP:0100530)1.82183982
145Sclerocornea (HP:0000647)1.81677465
146Hyperglycinemia (HP:0002154)1.81526581
147Hepatocellular necrosis (HP:0001404)1.79000515
148Limb dystonia (HP:0002451)1.78738567
149Postaxial hand polydactyly (HP:0001162)1.76273652
150Absent speech (HP:0001344)1.76213286
151Chronic hepatic failure (HP:0100626)1.75948809
152Purpura (HP:0000979)1.75907122
153Increased serum lactate (HP:0002151)1.75139791
154Epistaxis (HP:0000421)1.73415392
155Menstrual irregularities (HP:0000858)1.73219576
156Aplastic anemia (HP:0001915)1.72526959
157Abnormal hair whorl (HP:0010721)1.72163089
158Gaze-evoked nystagmus (HP:0000640)1.71545785
159Recurrent gram-negative bacterial infections (HP:0005420)1.70913945
160Supernumerary spleens (HP:0009799)1.70335750
161Anencephaly (HP:0002323)1.69686343
162Hypochromic microcytic anemia (HP:0004840)1.69450710
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.68539689
164Methylmalonic aciduria (HP:0012120)1.68154065
165Cystic liver disease (HP:0006706)1.68149779
166Male pseudohermaphroditism (HP:0000037)1.68028696
167Optic nerve hypoplasia (HP:0000609)1.66561998
168Retinal dysplasia (HP:0007973)1.66095398
169Adactyly (HP:0009776)1.65952766
170Hypoproteinemia (HP:0003075)1.65883531
171Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65609063
172Pendular nystagmus (HP:0012043)1.63520623
173Abnormality of macular pigmentation (HP:0008002)1.62623855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.86783395
2MAP4K13.56606621
3MAP3K123.40874733
4ZAP702.91310559
5BCR2.88004704
6FRK2.55340788
7MAP3K42.50490067
8TRIM282.43868666
9ITK2.41450479
10IKBKE2.40851120
11WNK32.39554915
12INSRR2.25273539
13MAP4K22.25152799
14BMPR22.23282942
15TBK12.16525731
16CAMKK22.13505557
17JAK32.10939469
18MST42.09766291
19BLK2.07455512
20IRAK41.86223996
21TEC1.85855023
22CASK1.81898883
23NUAK11.78618222
24PINK11.76200833
25KIT1.74936652
26ZAK1.73527914
27SYK1.69368623
28RIPK41.55634396
29NME21.55514220
30LCK1.53517350
31FES1.47292615
32CSNK1G31.44552164
33ADRBK21.43892882
34DYRK21.42355263
35SIK31.41741567
36PIM21.40731095
37TYK21.39964920
38CDK191.39826968
39CSNK1G11.34581958
40CSNK1G21.34090884
41JAK11.31447361
42MAP3K91.30731626
43MAP3K141.29003609
44MAP2K71.28074386
45CSNK1A1L1.27986465
46BTK1.25928760
47FLT31.22590759
48NLK1.22035677
49FGFR41.21760222
50HIPK21.21073796
51MAP3K21.18367521
52MAPKAPK31.17752391
53FGFR31.16396411
54SRPK11.16241632
55ARAF1.12759051
56GRK11.08036288
57PRKCH1.07792786
58BCKDK1.07417381
59HCK1.03922359
60GRK61.03269016
61ACVR1B1.00600667
62MAP3K131.00445320
63KSR20.99474934
64MINK10.99076097
65LIMK10.98131324
66IKBKB0.97410477
67DYRK30.95622888
68IRAK10.95279985
69TESK20.93672215
70NTRK10.92361673
71MAP3K10.91523265
72PAK30.91369441
73VRK10.91323069
74RPS6KA40.87711027
75ERBB30.86427757
76TNK20.85905685
77MAPKAPK50.84964142
78NTRK30.84370586
79MARK10.82420453
80CSK0.81368606
81CLK10.80174787
82PRKCE0.79432287
83PRKCG0.79029622
84MKNK20.78980636
85PLK20.78668732
86NTRK20.78300989
87NEK90.77740096
88TLK10.76121636
89SCYL20.74967871
90KDR0.73945988
91LYN0.73747275
92CAMKK10.73078957
93OXSR10.71461884
94PRKCQ0.71292370
95DAPK10.68497964
96LRRK20.67980060
97RPS6KA50.67810855
98UHMK10.65511935
99TGFBR20.63791163
100MARK20.61310066
101BRD40.59933625
102GRK70.59882033
103MKNK10.59328009
104TESK10.57030924
105ADRBK10.56668038
106CCNB10.56283957
107BMPR1B0.55841562
108RAF10.55703677
109MAP2K30.53961786
110JAK20.53219538
111PLK30.53137837
112RET0.52627392
113MAP3K50.52154284
114MAP2K40.52093688
115DYRK1A0.51851955
116EPHA30.51767906
117MARK30.50847109
118FYN0.49853397
119MAPK150.49572668
120SIK20.48699099
121IGF1R0.48352743
122PRKG20.48013059
123TNIK0.47568830
124PIK3CA0.46870449
125TRPM70.45485104
126CAMK2A0.44779558
127EPHB10.44388516
128STK100.44259684
129PASK0.43805910
130BRSK20.43222960
131EGFR0.43039786
132PIM10.42520944
133TAOK30.42459995
134CDK30.41432439
135MAP3K30.41413538
136MAPK130.41036925
137STK160.40669500
138CSF1R0.40592762
139PRKD20.39110260
140DAPK20.38981952
141PDK10.38846324
142DYRK1B0.38706298
143EEF2K0.36629442
144RPS6KA20.35928789
145ILK0.35210019
146CDK50.34504220
147YES10.34279508
148IRAK20.34103911
149PRPF4B0.32915153
150CSNK1D0.32638155
151MYLK0.31738536
152MAP2K60.30323304

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.59266144
2Primary immunodeficiency_Homo sapiens_hsa053402.86178261
3Protein export_Homo sapiens_hsa030602.45335744
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43843631
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35405883
6T cell receptor signaling pathway_Homo sapiens_hsa046602.35043222
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34966901
8Nicotine addiction_Homo sapiens_hsa050332.28033412
9Butanoate metabolism_Homo sapiens_hsa006502.14858701
10Phototransduction_Homo sapiens_hsa047442.11411621
11Basal transcription factors_Homo sapiens_hsa030222.04101429
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94353701
13Graft-versus-host disease_Homo sapiens_hsa053321.89813700
14Allograft rejection_Homo sapiens_hsa053301.86322451
15RNA degradation_Homo sapiens_hsa030181.80477705
16RNA polymerase_Homo sapiens_hsa030201.79871294
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.76748264
18Leishmaniasis_Homo sapiens_hsa051401.68484852
19Antigen processing and presentation_Homo sapiens_hsa046121.67465792
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65596559
21Measles_Homo sapiens_hsa051621.63392507
22Type I diabetes mellitus_Homo sapiens_hsa049401.54110690
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53206974
24Osteoclast differentiation_Homo sapiens_hsa043801.48531647
25Hematopoietic cell lineage_Homo sapiens_hsa046401.43836182
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42946636
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42508903
28Linoleic acid metabolism_Homo sapiens_hsa005911.40527430
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37981590
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37702901
31Synaptic vesicle cycle_Homo sapiens_hsa047211.37694329
32Huntingtons disease_Homo sapiens_hsa050161.36815630
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34526331
34Rheumatoid arthritis_Homo sapiens_hsa053231.33816848
35Shigellosis_Homo sapiens_hsa051311.33566882
36Nitrogen metabolism_Homo sapiens_hsa009101.32784704
37Vibrio cholerae infection_Homo sapiens_hsa051101.31818367
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31261504
39Chemokine signaling pathway_Homo sapiens_hsa040621.30953072
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30196396
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25492127
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25161180
43Other glycan degradation_Homo sapiens_hsa005111.22714362
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22595065
45Collecting duct acid secretion_Homo sapiens_hsa049661.21078509
46Propanoate metabolism_Homo sapiens_hsa006401.18563172
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15116629
48Asthma_Homo sapiens_hsa053101.13727218
49Autoimmune thyroid disease_Homo sapiens_hsa053201.13519342
50Homologous recombination_Homo sapiens_hsa034401.12645188
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12505945
52Lysosome_Homo sapiens_hsa041421.12338775
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.11726760
54Taste transduction_Homo sapiens_hsa047421.10932073
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.10348736
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09929999
57Olfactory transduction_Homo sapiens_hsa047401.09759446
58Viral myocarditis_Homo sapiens_hsa054161.07782278
59Spliceosome_Homo sapiens_hsa030401.07765484
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07053382
61B cell receptor signaling pathway_Homo sapiens_hsa046621.06887392
62Salmonella infection_Homo sapiens_hsa051321.05094220
63Tuberculosis_Homo sapiens_hsa051521.04924723
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.03390631
65Pertussis_Homo sapiens_hsa051331.03270366
66Ribosome_Homo sapiens_hsa030101.02161835
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01401878
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99897577
69Phagosome_Homo sapiens_hsa041450.99352634
70Ether lipid metabolism_Homo sapiens_hsa005650.96885081
71Fanconi anemia pathway_Homo sapiens_hsa034600.95848316
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95280596
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91826197
74Long-term potentiation_Homo sapiens_hsa047200.91479857
75Legionellosis_Homo sapiens_hsa051340.90447991
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90304007
77Peroxisome_Homo sapiens_hsa041460.88046469
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87693561
79Circadian rhythm_Homo sapiens_hsa047100.86370162
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.86327480
81Endocytosis_Homo sapiens_hsa041440.85221248
82Prolactin signaling pathway_Homo sapiens_hsa049170.84753516
83Platelet activation_Homo sapiens_hsa046110.84387304
84Cholinergic synapse_Homo sapiens_hsa047250.83997371
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83847402
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.83638130
87Toxoplasmosis_Homo sapiens_hsa051450.83460618
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83363708
89Insulin secretion_Homo sapiens_hsa049110.82401202
90Proteasome_Homo sapiens_hsa030500.82213145
91Acute myeloid leukemia_Homo sapiens_hsa052210.81638857
92Selenocompound metabolism_Homo sapiens_hsa004500.81394791
93Dopaminergic synapse_Homo sapiens_hsa047280.81323198
94Hepatitis B_Homo sapiens_hsa051610.80396981
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78930102
96TNF signaling pathway_Homo sapiens_hsa046680.78103764
97Pancreatic cancer_Homo sapiens_hsa052120.77831554
98Apoptosis_Homo sapiens_hsa042100.77044596
99Morphine addiction_Homo sapiens_hsa050320.76296501
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74346576
101Serotonergic synapse_Homo sapiens_hsa047260.73619565
102Oxidative phosphorylation_Homo sapiens_hsa001900.72705133
103Non-homologous end-joining_Homo sapiens_hsa034500.71614965
104Influenza A_Homo sapiens_hsa051640.70896219
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70806406
106Tryptophan metabolism_Homo sapiens_hsa003800.69415326
107Hepatitis C_Homo sapiens_hsa051600.69100008
108Parkinsons disease_Homo sapiens_hsa050120.68821613
109N-Glycan biosynthesis_Homo sapiens_hsa005100.67686348
110Caffeine metabolism_Homo sapiens_hsa002320.67480650
111Thyroid cancer_Homo sapiens_hsa052160.66383705
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66373015
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66050690
114Alzheimers disease_Homo sapiens_hsa050100.64865632
115Colorectal cancer_Homo sapiens_hsa052100.64529908
116Circadian entrainment_Homo sapiens_hsa047130.63685156
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63109908
118Sphingolipid metabolism_Homo sapiens_hsa006000.63004987
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61118743
120VEGF signaling pathway_Homo sapiens_hsa043700.60921848
121Herpes simplex infection_Homo sapiens_hsa051680.60916308
122Cardiac muscle contraction_Homo sapiens_hsa042600.60780143
123Malaria_Homo sapiens_hsa051440.58856681
124Glutamatergic synapse_Homo sapiens_hsa047240.58666647
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56401630
126Cocaine addiction_Homo sapiens_hsa050300.54024228
127beta-Alanine metabolism_Homo sapiens_hsa004100.52644400
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.52529909
129Purine metabolism_Homo sapiens_hsa002300.52384917
130Steroid biosynthesis_Homo sapiens_hsa001000.51305640
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51284675
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51082537
133GABAergic synapse_Homo sapiens_hsa047270.50112846
134RNA transport_Homo sapiens_hsa030130.49754498
135Gastric acid secretion_Homo sapiens_hsa049710.49116517
136Amphetamine addiction_Homo sapiens_hsa050310.49034320
137Regulation of autophagy_Homo sapiens_hsa041400.48915583
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48297103
139Long-term depression_Homo sapiens_hsa047300.47536787
140Epstein-Barr virus infection_Homo sapiens_hsa051690.46937237
141ABC transporters_Homo sapiens_hsa020100.45900403
142Nucleotide excision repair_Homo sapiens_hsa034200.42107549
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38053375
144Fatty acid elongation_Homo sapiens_hsa000620.35052454
145Arachidonic acid metabolism_Homo sapiens_hsa005900.34451419
146Renin secretion_Homo sapiens_hsa049240.33856815
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.33772100
148Metabolic pathways_Homo sapiens_hsa011000.31922831
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24710361
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.23353144

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