LETMD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)5.69199709
2tricarboxylic acid cycle (GO:0006099)4.92386463
3carnitine shuttle (GO:0006853)4.74437327
4fatty acid beta-oxidation (GO:0006635)4.68482894
5regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.67098314
6regulation of sequestering of triglyceride (GO:0010889)4.58837062
7succinate metabolic process (GO:0006105)4.56365910
8regulation of acyl-CoA biosynthetic process (GO:0050812)4.46755325
9biotin metabolic process (GO:0006768)4.40943249
10fatty acid transmembrane transport (GO:1902001)4.39634812
11fatty acid catabolic process (GO:0009062)4.34651705
12ketone body metabolic process (GO:1902224)4.29525541
13regulation of fatty acid oxidation (GO:0046320)4.24281263
14regulation of cofactor metabolic process (GO:0051193)4.09022298
15regulation of coenzyme metabolic process (GO:0051196)4.09022298
16thioester biosynthetic process (GO:0035384)4.08755835
17acyl-CoA biosynthetic process (GO:0071616)4.08755835
18fatty acid oxidation (GO:0019395)4.08348141
19lipid oxidation (GO:0034440)4.00555437
20coenzyme A biosynthetic process (GO:0015937)3.87220612
21tricarboxylic acid metabolic process (GO:0072350)3.84875702
22acetyl-CoA metabolic process (GO:0006084)3.79963854
23fatty-acyl-CoA biosynthetic process (GO:0046949)3.76835764
24carnitine transmembrane transport (GO:1902603)3.70265266
25monocarboxylic acid catabolic process (GO:0072329)3.63860611
26lysine catabolic process (GO:0006554)3.63370736
27lysine metabolic process (GO:0006553)3.63370736
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.58938483
29fatty-acyl-CoA metabolic process (GO:0035337)3.58455087
30valine metabolic process (GO:0006573)3.55933592
31triglyceride catabolic process (GO:0019433)3.55906470
32preassembly of GPI anchor in ER membrane (GO:0016254)3.54893695
33regulation of sulfur metabolic process (GO:0042762)3.52364810
34neutral lipid catabolic process (GO:0046461)3.51882829
35acylglycerol catabolic process (GO:0046464)3.51882829
36coenzyme A metabolic process (GO:0015936)3.51540466
37amino-acid betaine transport (GO:0015838)3.48171760
38carnitine transport (GO:0015879)3.48171760
39long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.47902945
40cardiolipin metabolic process (GO:0032048)3.47353182
41drug catabolic process (GO:0042737)3.46953799
42carnitine metabolic process (GO:0009437)3.45872242
43short-chain fatty acid metabolic process (GO:0046459)3.45870068
44branched-chain amino acid catabolic process (GO:0009083)3.44797945
45pyrimidine nucleobase catabolic process (GO:0006208)3.43605365
46S-adenosylmethionine metabolic process (GO:0046500)3.38020922
47proline transport (GO:0015824)3.36742550
48alpha-linolenic acid metabolic process (GO:0036109)3.35241165
49branched-chain amino acid metabolic process (GO:0009081)3.32118791
50L-fucose catabolic process (GO:0042355)3.31188508
51fucose catabolic process (GO:0019317)3.31188508
52L-fucose metabolic process (GO:0042354)3.31188508
53glycine transport (GO:0015816)3.27559495
54thioester metabolic process (GO:0035383)3.25483256
55acyl-CoA metabolic process (GO:0006637)3.25483256
56neural tube formation (GO:0001841)3.23908410
57regulation of cholesterol metabolic process (GO:0090181)3.23364660
58long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.18975126
59regulation of triglyceride catabolic process (GO:0010896)3.17952376
60positive regulation of fatty acid oxidation (GO:0046321)3.16812351
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14521664
62pentose-phosphate shunt (GO:0006098)3.13872457
63triglyceride biosynthetic process (GO:0019432)3.13104024
64positive regulation of fatty acid beta-oxidation (GO:0032000)3.11372036
65quinone biosynthetic process (GO:1901663)3.08046246
66ubiquinone biosynthetic process (GO:0006744)3.08046246
67exogenous drug catabolic process (GO:0042738)3.07280000
68behavioral response to nicotine (GO:0035095)3.07010787
69regulation of fatty acid beta-oxidation (GO:0031998)3.04566614
70quaternary ammonium group transport (GO:0015697)3.03406561
71ribosomal small subunit assembly (GO:0000028)3.03355575
72oxaloacetate metabolic process (GO:0006107)3.02569417
73negative regulation of erythrocyte differentiation (GO:0045647)3.00538924
74amino-acid betaine metabolic process (GO:0006577)2.96021701
75alanine transport (GO:0032328)2.95608934
76neutral lipid biosynthetic process (GO:0046460)2.94489643
77acylglycerol biosynthetic process (GO:0046463)2.94489643
78NADPH regeneration (GO:0006740)2.93769753
79response to pheromone (GO:0019236)2.91961728
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.91402875
81brown fat cell differentiation (GO:0050873)2.90727601
822-oxoglutarate metabolic process (GO:0006103)2.90564535
83very long-chain fatty acid metabolic process (GO:0000038)2.84995978
84protein import into peroxisome matrix (GO:0016558)2.83418136
85synaptic vesicle maturation (GO:0016188)2.81706165
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81233983
87positive regulation of respiratory burst (GO:0060267)2.80469915
88cilium or flagellum-dependent cell motility (GO:0001539)2.80030440
89arginine catabolic process (GO:0006527)2.79040611
90nephron tubule morphogenesis (GO:0072078)2.78019693
91nephron epithelium morphogenesis (GO:0072088)2.78019693
92ubiquinone metabolic process (GO:0006743)2.77896507
93nucleobase catabolic process (GO:0046113)2.77149361
94reciprocal DNA recombination (GO:0035825)2.76986013
95reciprocal meiotic recombination (GO:0007131)2.76986013
96synaptic vesicle docking involved in exocytosis (GO:0016081)2.76065748
97oxidative phosphorylation (GO:0006119)2.75694965
98cornea development in camera-type eye (GO:0061303)2.72731610
99alkaloid metabolic process (GO:0009820)2.72498450
100detection of light stimulus involved in sensory perception (GO:0050962)2.72005150
101detection of light stimulus involved in visual perception (GO:0050908)2.72005150
102axoneme assembly (GO:0035082)2.71710394
103positive regulation of CREB transcription factor activity (GO:0032793)2.70859673
104C-terminal protein lipidation (GO:0006501)2.69910031
105aldehyde catabolic process (GO:0046185)2.69839289
106cellular lipid catabolic process (GO:0044242)2.69729875
107pantothenate metabolic process (GO:0015939)2.69540790
108cellular ketone body metabolic process (GO:0046950)2.69236662
109negative regulation of lipase activity (GO:0060192)2.67844141
110arginine metabolic process (GO:0006525)2.67599115
111neurotransmitter catabolic process (GO:0042135)2.67215033
112positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.67092403
113epithelial cilium movement (GO:0003351)2.65276804
114negative regulation of telomere maintenance (GO:0032205)2.64908838
115purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.64806942
116ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.64806942
117nucleoside bisphosphate biosynthetic process (GO:0033866)2.64806942
118coenzyme catabolic process (GO:0009109)2.64763047
119negative regulation of protein oligomerization (GO:0032460)2.63340835
120regulation of microtubule-based movement (GO:0060632)2.63045275
121synaptic vesicle exocytosis (GO:0016079)2.62711727
122glycerolipid catabolic process (GO:0046503)2.62308773
123aspartate family amino acid catabolic process (GO:0009068)2.61669461
124respiratory electron transport chain (GO:0022904)2.60338417
125positive regulation of granulocyte differentiation (GO:0030854)2.60057194
126peroxisome fission (GO:0016559)2.59084941
127replication fork processing (GO:0031297)2.57954627
128electron transport chain (GO:0022900)2.57937131
129DNA methylation involved in gamete generation (GO:0043046)2.57824357
130erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.57117039
131L-phenylalanine catabolic process (GO:0006559)2.57117039
132regulation of gamma-delta T cell differentiation (GO:0045586)2.55848925
133fatty acid elongation (GO:0030497)2.54723742
134platelet dense granule organization (GO:0060155)2.54689170
135rRNA catabolic process (GO:0016075)2.54128218
136organic acid catabolic process (GO:0016054)2.53702647
137carboxylic acid catabolic process (GO:0046395)2.53702647
138double-strand break repair via homologous recombination (GO:0000724)2.53164910
139recombinational repair (GO:0000725)2.52962848
140positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.52397211
141mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.52397211
142positive regulation of developmental pigmentation (GO:0048087)2.52298106
143viral transcription (GO:0019083)2.52046953
144regulation of cilium movement (GO:0003352)2.51782095
145aerobic respiration (GO:0009060)2.51306109
146lipid storage (GO:0019915)2.50731620
147GMP metabolic process (GO:0046037)2.50521282
148triglyceride metabolic process (GO:0006641)2.50232023
149indolalkylamine metabolic process (GO:0006586)2.49995965
150NAD metabolic process (GO:0019674)2.49929069
151DNA deamination (GO:0045006)2.49186679
152respiratory chain complex IV assembly (GO:0008535)2.48420829
153piRNA metabolic process (GO:0034587)2.46777322
154translational termination (GO:0006415)2.45856772
155protein-cofactor linkage (GO:0018065)2.45693311
156indole-containing compound catabolic process (GO:0042436)2.45155384
157indolalkylamine catabolic process (GO:0046218)2.45155384
158tryptophan catabolic process (GO:0006569)2.45155384
159resolution of meiotic recombination intermediates (GO:0000712)2.43843499
160fucosylation (GO:0036065)2.43203399
161one-carbon compound transport (GO:0019755)2.41885327
162glycerophospholipid catabolic process (GO:0046475)2.40605920
163synapsis (GO:0007129)2.40011034
164histone H3-K9 methylation (GO:0051567)2.38989797
165phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38797965
166regulation of histone H3-K4 methylation (GO:0051569)2.37865001
167kynurenine metabolic process (GO:0070189)2.37195864
168negative regulation of sodium ion transport (GO:0010766)2.36414562
169phosphatidylserine acyl-chain remodeling (GO:0036150)2.35984440
170negative regulation of macrophage differentiation (GO:0045650)2.33785720
171photoreceptor cell maintenance (GO:0045494)2.33202184
172C-terminal protein amino acid modification (GO:0018410)2.32427878
173autophagic vacuole fusion (GO:0000046)2.31396696
174keratinocyte development (GO:0003334)2.30842249
175GPI anchor metabolic process (GO:0006505)2.29561650
176drug metabolic process (GO:0017144)2.29460482
177neurotransmitter metabolic process (GO:0042133)2.28882469
178positive regulation of glycolytic process (GO:0045821)2.28768569
179dentate gyrus development (GO:0021542)2.28715909
180protein localization to cilium (GO:0061512)2.28152551
181cilium movement (GO:0003341)2.27931466
182male meiosis I (GO:0007141)2.26819727
183water-soluble vitamin biosynthetic process (GO:0042364)2.26537307
184regulation of granulocyte differentiation (GO:0030852)2.24715644
185male meiosis (GO:0007140)2.24386279
186Peyers patch development (GO:0048541)2.24339578
187mucosal-associated lymphoid tissue development (GO:0048537)2.24339578
188phenylpropanoid metabolic process (GO:0009698)2.23768455
189spliceosomal complex assembly (GO:0000245)2.22807189
190tyrosine metabolic process (GO:0006570)2.22452147
191cAMP catabolic process (GO:0006198)2.22365231
192vitamin transmembrane transport (GO:0035461)2.20323313
193auditory receptor cell stereocilium organization (GO:0060088)2.20203966
194tryptophan metabolic process (GO:0006568)2.18343355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.00503339
2ZNF274_21170338_ChIP-Seq_K562_Hela4.24547550
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.03616273
4SCL_19346495_ChIP-Seq_HPC-7_Human3.31194365
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.27290251
6VDR_22108803_ChIP-Seq_LS180_Human2.84364143
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.69248834
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.65182515
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48497731
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47096608
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27244666
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.24342192
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.20815610
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.18335068
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15485580
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10924256
17ER_23166858_ChIP-Seq_MCF-7_Human2.06822006
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05867865
19GBX2_23144817_ChIP-Seq_PC3_Human2.03844359
20EZH2_22144423_ChIP-Seq_EOC_Human2.03732704
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03151073
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02468896
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.00644049
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.91794175
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87811728
26AR_21572438_ChIP-Seq_LNCaP_Human1.86402662
27IGF1R_20145208_ChIP-Seq_DFB_Human1.83881848
28GATA1_22025678_ChIP-Seq_K562_Human1.82965677
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82765232
30* EST1_17652178_ChIP-ChIP_JURKAT_Human1.82741354
31FUS_26573619_Chip-Seq_HEK293_Human1.76788088
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72636966
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.72222499
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68629880
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67495095
36* VDR_23849224_ChIP-Seq_CD4+_Human1.67210969
37MYC_18940864_ChIP-ChIP_HL60_Human1.66962573
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64676190
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64515083
40CIITA_25753668_ChIP-Seq_RAJI_Human1.61670723
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.59309495
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58600226
43KDM5A_27292631_Chip-Seq_BREAST_Human1.56121355
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55096153
45EWS_26573619_Chip-Seq_HEK293_Human1.54842832
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.54623680
47TP53_22573176_ChIP-Seq_HFKS_Human1.54325719
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52279957
49* REST_18959480_ChIP-ChIP_MESCs_Mouse1.51459945
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51312869
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.50730973
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49364021
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.49069006
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47382783
55RUNX_20019798_ChIP-Seq_JUKART_Human1.43946329
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43667891
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43418340
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40711870
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40298671
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.40174111
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38391049
62FOXP3_21729870_ChIP-Seq_TREG_Human1.37769690
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37743162
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37263109
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37049900
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36968755
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36495555
68ERA_21632823_ChIP-Seq_H3396_Human1.36396848
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35832326
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34848841
71VDR_21846776_ChIP-Seq_THP-1_Human1.34136131
72IRF1_19129219_ChIP-ChIP_H3396_Human1.30934968
73HOXB7_26014856_ChIP-Seq_BT474_Human1.29671176
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29147172
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27137402
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27079930
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.27079930
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26262931
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25909015
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24852764
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23667778
82CBP_20019798_ChIP-Seq_JUKART_Human1.23667778
83MYC_22102868_ChIP-Seq_BL_Human1.23512647
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23126100
85STAT3_23295773_ChIP-Seq_U87_Human1.22961805
86* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22847520
87TCF4_23295773_ChIP-Seq_U87_Human1.22140815
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21410682
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21394082
90AR_20517297_ChIP-Seq_VCAP_Human1.20981139
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20729689
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19057412
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18379935
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16826129
95NCOR_22424771_ChIP-Seq_293T_Human1.16208251
96* REST_21632747_ChIP-Seq_MESCs_Mouse1.15562157
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15418742
98RNF2_27304074_Chip-Seq_NSC_Mouse1.14540638
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13861768
100LXR_22292898_ChIP-Seq_THP-1_Human1.13848107
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13488467
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.11380297
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10538739
104P53_21459846_ChIP-Seq_SAOS-2_Human1.10364274
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09504721
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09006582
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08722393
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.07790258
109BCAT_22108803_ChIP-Seq_LS180_Human1.06832407
110JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06778873
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06678378
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06658876
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06013280
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.05763903
115VDR_24763502_ChIP-Seq_THP-1_Human1.05117381
116MYC_19829295_ChIP-Seq_ESCs_Human1.04804145
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04269117
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03602551
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03200129
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02712094
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02596901
122BCL6_27268052_Chip-Seq_Bcells_Human1.02232611
123AR_25329375_ChIP-Seq_VCAP_Human1.02048812
124RAC3_21632823_ChIP-Seq_H3396_Human1.01276960
125RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99649652
126RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99646161
127EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99646161
128SPI1_23127762_ChIP-Seq_K562_Human0.99188565
129OCT4_20526341_ChIP-Seq_ESCs_Human0.98645820
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97922233
131TCF4_22108803_ChIP-Seq_LS180_Human0.97100427
132* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96692681
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96125575
134DROSHA_22980978_ChIP-Seq_HELA_Human0.96068820
135NOTCH1_21737748_ChIP-Seq_TLL_Human0.95897841
136SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95847424
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95242085
138* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94870840
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94655090
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93574207
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93524858
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93302990
143* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93103476
144FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92352305
145E2F1_20622854_ChIP-Seq_HELA_Human0.91769492
146FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91600065
147RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90919587
148WDR5_24793694_ChIP-Seq_LNCAP_Human0.90339046
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90335380
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90181858
151ELK1_19687146_ChIP-ChIP_HELA_Human0.90136314
152NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89805211
153* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89410742
154TAF2_19829295_ChIP-Seq_ESCs_Human0.89195951
155YY1_21170310_ChIP-Seq_MESCs_Mouse0.88922002
156TTF2_22483619_ChIP-Seq_HELA_Human0.88433964
157THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88049883
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87348225
159GATA3_26560356_Chip-Seq_TH2_Human0.86810598
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.86154521
161TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85908268
162TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85561826
163PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85310865
164GABP_19822575_ChIP-Seq_HepG2_Human0.85103472
165MAF_26560356_Chip-Seq_TH2_Human0.84444658
166GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84046783
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83482835
168SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81749395
169SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81710354
170KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81686379
171JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81471234
172HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81283753
173EZH2_27304074_Chip-Seq_ESCs_Mouse0.81062978
174ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80807178
175TAF15_26573619_Chip-Seq_HEK293_Human0.80546788
176MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79261147
177KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78638609
178RUNX1_22412390_ChIP-Seq_EML_Mouse0.78385708
179MAF_26560356_Chip-Seq_TH1_Human0.77784316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.47765061
2MP0004859_abnormal_synaptic_plasticity3.09857924
3MP0004130_abnormal_muscle_cell2.93493168
4MP0008995_early_reproductive_senescence2.62767078
5MP0005365_abnormal_bile_salt2.60755989
6MP0010329_abnormal_lipoprotein_level2.54507950
7MP0005666_abnormal_adipose_tissue2.51617173
8MP0002971_abnormal_brown_adipose2.51090202
9MP0005535_abnormal_body_temperature2.44220463
10MP0004043_abnormal_pH_regulation2.38504981
11MP0006036_abnormal_mitochondrial_physio2.27002462
12MP0005551_abnormal_eye_electrophysiolog2.20083299
13MP0005584_abnormal_enzyme/coenzyme_acti2.17966784
14MP0003656_abnormal_erythrocyte_physiolo2.17056748
15MP0000566_synostosis2.08783392
16MP0003880_abnormal_central_pattern2.06668278
17MP0003191_abnormal_cellular_cholesterol2.02350047
18MP0002139_abnormal_hepatobiliary_system1.94280740
19MP0005360_urolithiasis1.93063419
20MP0002118_abnormal_lipid_homeostasis1.91226174
21MP0003635_abnormal_synaptic_transmissio1.89656598
22MP0002638_abnormal_pupillary_reflex1.84666995
23MP0005332_abnormal_amino_acid1.81573581
24MP0002009_preneoplasia1.79520783
25MP0001968_abnormal_touch/_nociception1.75364257
26MP0002822_catalepsy1.74491854
27MP0008877_abnormal_DNA_methylation1.74043857
28MP0004147_increased_porphyrin_level1.72466194
29MP0006292_abnormal_olfactory_placode1.70722220
30MP0003195_calcinosis1.70524918
31MP0005645_abnormal_hypothalamus_physiol1.69787902
32MP0008872_abnormal_physiological_respon1.69582503
33MP0005085_abnormal_gallbladder_physiolo1.69305701
34MP0002396_abnormal_hematopoietic_system1.65625147
35MP0008875_abnormal_xenobiotic_pharmacok1.62422598
36MP0004019_abnormal_vitamin_homeostasis1.60721382
37MP0004185_abnormal_adipocyte_glucose1.59292146
38MP0005423_abnormal_somatic_nervous1.57290873
39MP0008058_abnormal_DNA_repair1.55608523
40MP0005174_abnormal_tail_pigmentation1.54205952
41MP0000427_abnormal_hair_cycle1.51377986
42MP0002970_abnormal_white_adipose1.51185691
43MP0003329_amyloid_beta_deposits1.50824560
44MP0009745_abnormal_behavioral_response1.49849313
45MP0001984_abnormal_olfaction1.49487936
46MP0003787_abnormal_imprinting1.48895304
47MP0000372_irregular_coat_pigmentation1.48882259
48MP0002736_abnormal_nociception_after1.48876973
49MP0004270_analgesia1.47842382
50MP0002063_abnormal_learning/memory/cond1.47772254
51MP0005375_adipose_tissue_phenotype1.46607113
52MP0009840_abnormal_foam_cell1.44185451
53MP0006035_abnormal_mitochondrial_morpho1.40175381
54MP0001986_abnormal_taste_sensitivity1.39240099
55MP0005083_abnormal_biliary_tract1.38952088
56MP0000609_abnormal_liver_physiology1.38164427
57MP0001905_abnormal_dopamine_level1.37928715
58MP0005075_abnormal_melanosome_morpholog1.37922271
59MP0002064_seizures1.34897146
60MP0003183_abnormal_peptide_metabolism1.34098576
61MP0002938_white_spotting1.29107117
62MP0005671_abnormal_response_to1.29024671
63MP0002078_abnormal_glucose_homeostasis1.28270551
64MP0005448_abnormal_energy_balance1.27541334
65MP0008569_lethality_at_weaning1.27323672
66MP0002909_abnormal_adrenal_gland1.27184223
67MP0002234_abnormal_pharynx_morphology1.27079680
68MP0003136_yellow_coat_color1.26798535
69MP0005334_abnormal_fat_pad1.26547006
70MP0005646_abnormal_pituitary_gland1.23871499
71MP0002095_abnormal_skin_pigmentation1.23672584
72MP0000569_abnormal_digit_pigmentation1.23537163
73MP0003724_increased_susceptibility_to1.22267005
74MP0002272_abnormal_nervous_system1.19906388
75MP0005410_abnormal_fertilization1.19457801
76MP0002572_abnormal_emotion/affect_behav1.16342411
77MP0000631_abnormal_neuroendocrine_gland1.16341692
78MP0006276_abnormal_autonomic_nervous1.15441490
79MP0004885_abnormal_endolymph1.14262803
80MP0003633_abnormal_nervous_system1.13744557
81MP0004142_abnormal_muscle_tone1.13348986
82MP0000383_abnormal_hair_follicle1.12687825
83MP0002735_abnormal_chemical_nociception1.11522747
84MP0005171_absent_coat_pigmentation1.11205351
85MP0009115_abnormal_fat_cell1.10515501
86MP0005452_abnormal_adipose_tissue1.10080011
87MP0002067_abnormal_sensory_capabilities1.08396540
88MP0000920_abnormal_myelination1.08383525
89MP0003172_abnormal_lysosome_physiology1.07711317
90MP0000604_amyloidosis1.07612844
91MP0008961_abnormal_basal_metabolism1.07512138
92MP0009379_abnormal_foot_pigmentation1.07358335
93MP0002160_abnormal_reproductive_system1.06106253
94MP0002733_abnormal_thermal_nociception1.05881377
95MP0005319_abnormal_enzyme/_coenzyme1.05469195
96MP0001545_abnormal_hematopoietic_system1.04801273
97MP0005397_hematopoietic_system_phenotyp1.04801273
98MP0008775_abnormal_heart_ventricle1.04519273
99MP0001944_abnormal_pancreas_morphology1.04237236
100MP0005464_abnormal_platelet_physiology1.04106399
101MP0001970_abnormal_pain_threshold1.03159236
102MP0002876_abnormal_thyroid_physiology1.02971794
103MP0009046_muscle_twitch1.01944037
104MP0003690_abnormal_glial_cell1.01559189
105MP0003868_abnormal_feces_composition1.01009168
106MP0003763_abnormal_thymus_physiology1.00211396
107MP0005253_abnormal_eye_physiology0.99051307
108MP0001502_abnormal_circadian_rhythm0.98656063
109MP0003698_abnormal_male_reproductive0.97713172
110MP0004924_abnormal_behavior0.96375209
111MP0005386_behavior/neurological_phenoty0.96375209
112MP0003646_muscle_fatigue0.94895243
113MP0008874_decreased_physiological_sensi0.94733971
114MP0004811_abnormal_neuron_physiology0.94312659
115MP0005636_abnormal_mineral_homeostasis0.93948765
116MP0001486_abnormal_startle_reflex0.93323576
117MP0004742_abnormal_vestibular_system0.93203482
118MP0003718_maternal_effect0.92999667
119MP0001835_abnormal_antigen_presentation0.92550241
120MP0000685_abnormal_immune_system0.91360755
121MP0002734_abnormal_mechanical_nocicepti0.91242469
122MP0003959_abnormal_lean_body0.90851489
123MP0002928_abnormal_bile_duct0.89866479
124MP0002069_abnormal_eating/drinking_beha0.89839135
125MP0003011_delayed_dark_adaptation0.89362135
126MP0004133_heterotaxia0.88453479
127MP0000015_abnormal_ear_pigmentation0.88026393
128MP0001929_abnormal_gametogenesis0.86879431
129MP0000013_abnormal_adipose_tissue0.86690989
130MP0002693_abnormal_pancreas_physiology0.86029108
131MP0005389_reproductive_system_phenotype0.85959326
132MP0005084_abnormal_gallbladder_morpholo0.85667232
133MP0002837_dystrophic_cardiac_calcinosis0.84741146
134MP0002557_abnormal_social/conspecific_i0.83531477
135MP0002653_abnormal_ependyma_morphology0.83420233
136MP0001501_abnormal_sleep_pattern0.83110202
137MP0001765_abnormal_ion_homeostasis0.81071753
138MP0001661_extended_life_span0.81050787
139MP0001756_abnormal_urination0.80271447
140MP0002163_abnormal_gland_morphology0.79848857
141MP0003953_abnormal_hormone_level0.79701890
142MP0002398_abnormal_bone_marrow0.79687924
143MP0003879_abnormal_hair_cell0.78990784
144MP0001873_stomach_inflammation0.78398452
145MP0009785_altered_susceptibility_to0.78178882
146MP0001664_abnormal_digestion0.77384267
147MP0002132_abnormal_respiratory_system0.77162396
148MP0003786_premature_aging0.76398190
149MP0009643_abnormal_urine_homeostasis0.75862389

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.81789636
2Dicarboxylic aciduria (HP:0003215)4.43071967
3Abnormality of dicarboxylic acid metabolism (HP:0010995)4.43071967
4Hepatocellular necrosis (HP:0001404)4.39670881
5Hyperglycinuria (HP:0003108)4.13778556
6Abnormality of fatty-acid metabolism (HP:0004359)4.07571005
7Increased muscle lipid content (HP:0009058)3.73663960
8Congenital stationary night blindness (HP:0007642)3.68541209
9Abnormality of serine family amino acid metabolism (HP:0010894)3.63377938
10Abnormality of glycine metabolism (HP:0010895)3.63377938
11Methylmalonic aciduria (HP:0012120)3.59019313
12Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.55559654
13Generalized aminoaciduria (HP:0002909)3.53559245
14Pancreatic cysts (HP:0001737)3.50426720
15Abnormality of glycolysis (HP:0004366)3.44918615
16Increased serum pyruvate (HP:0003542)3.44918615
17Ketosis (HP:0001946)3.23360472
18Pancreatic fibrosis (HP:0100732)3.19295149
19Birth length less than 3rd percentile (HP:0003561)3.14929423
20Nephronophthisis (HP:0000090)3.11933234
21Lactic acidosis (HP:0003128)3.11005386
22Hyperammonemia (HP:0001987)3.10301048
23Oligomenorrhea (HP:0000876)3.08638598
24Cystic liver disease (HP:0006706)3.03042257
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02311224
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02311224
27Large for gestational age (HP:0001520)3.00997771
28Hyperventilation (HP:0002883)3.00672988
29Abnormality of the heme biosynthetic pathway (HP:0010472)2.98984179
30Ketoacidosis (HP:0001993)2.93292134
31Abnormality of the renal cortex (HP:0011035)2.92953323
32Acute encephalopathy (HP:0006846)2.90637940
33Abnormal mitochondria in muscle tissue (HP:0008316)2.89780999
34Abnormality of the renal medulla (HP:0100957)2.87583336
35Hypoglycemic coma (HP:0001325)2.85354055
36Increased CSF lactate (HP:0002490)2.83821362
37Myoglobinuria (HP:0002913)2.76941965
38Mitochondrial inheritance (HP:0001427)2.76682898
39Abnormality of cells of the erythroid lineage (HP:0012130)2.74601023
40Abnormal number of erythroid precursors (HP:0012131)2.71206581
41True hermaphroditism (HP:0010459)2.68551993
42Pheochromocytoma (HP:0002666)2.67954979
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67772844
44Abnormality of alanine metabolism (HP:0010916)2.67772844
45Hyperalaninemia (HP:0003348)2.67772844
46Decreased circulating renin level (HP:0003351)2.64575127
47Polyphagia (HP:0002591)2.64209784
48Increased intramyocellular lipid droplets (HP:0012240)2.63901297
49Molar tooth sign on MRI (HP:0002419)2.61226972
50Abnormality of midbrain morphology (HP:0002418)2.61226972
51Rhabdomyolysis (HP:0003201)2.57141973
52Acute necrotizing encephalopathy (HP:0006965)2.57138389
53Neuroendocrine neoplasm (HP:0100634)2.55638454
54Hyperglycinemia (HP:0002154)2.54902686
55Methylmalonic acidemia (HP:0002912)2.52684444
56Abnormal drinking behavior (HP:0030082)2.52136661
57Polydipsia (HP:0001959)2.52136661
58Abnormal biliary tract physiology (HP:0012439)2.51588499
59Bile duct proliferation (HP:0001408)2.51588499
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.51398269
61Cerebral edema (HP:0002181)2.49440355
62Febrile seizures (HP:0002373)2.48371331
63Hydroxyprolinuria (HP:0003080)2.48116117
64Abnormality of proline metabolism (HP:0010907)2.48116117
65Hypothermia (HP:0002045)2.46977342
66Attenuation of retinal blood vessels (HP:0007843)2.42967011
67Progressive cerebellar ataxia (HP:0002073)2.42823034
68Brushfield spots (HP:0001088)2.42333390
69Increased serum lactate (HP:0002151)2.41610903
70Lethargy (HP:0001254)2.40718130
71Hypoplasia of the thymus (HP:0000778)2.38466199
72Duplicated collecting system (HP:0000081)2.37229054
73Supranuclear gaze palsy (HP:0000605)2.34694160
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.34378454
75Absent/shortened dynein arms (HP:0200106)2.34378454
76Vomiting (HP:0002013)2.31104325
77Medial flaring of the eyebrow (HP:0010747)2.30339478
78Hyperlipoproteinemia (HP:0010980)2.29698623
79Progressive microcephaly (HP:0000253)2.29567577
80Elevated erythrocyte sedimentation rate (HP:0003565)2.29169604
81Abnormality of the pons (HP:0007361)2.28343667
82Alkalosis (HP:0001948)2.26541049
83Tubular atrophy (HP:0000092)2.25245272
843-Methylglutaconic aciduria (HP:0003535)2.24088815
85Panhypogammaglobulinemia (HP:0003139)2.23558561
86Metabolic acidosis (HP:0001942)2.23055059
87Abnormality of the renal collecting system (HP:0004742)2.22050662
88Limb hypertonia (HP:0002509)2.20706539
89Concave nail (HP:0001598)2.20329908
90Abnormality of serum amino acid levels (HP:0003112)2.16590301
91Hypertriglyceridemia (HP:0002155)2.15604727
92Respiratory failure (HP:0002878)2.14396039
93Abnormality of the labia minora (HP:0012880)2.12641378
94Poor eye contact (HP:0000817)2.12396520
95Delayed CNS myelination (HP:0002188)2.10303886
96Ragged-red muscle fibers (HP:0003200)2.10124897
97Decreased central vision (HP:0007663)2.09255052
98Type II lissencephaly (HP:0007260)2.08520320
99Focal motor seizures (HP:0011153)2.08037406
100Gastrointestinal stroma tumor (HP:0100723)2.07850310
101Poor suck (HP:0002033)2.07199234
102Abnormal rod and cone electroretinograms (HP:0008323)2.06700602
103Nephrogenic diabetes insipidus (HP:0009806)2.06576186
104Abnormality of renin-angiotensin system (HP:0000847)2.06063973
105Abnormal eating behavior (HP:0100738)2.05318319
106Thyroid-stimulating hormone excess (HP:0002925)2.03548878
107Cerebellar dysplasia (HP:0007033)2.03188173
108Progressive macrocephaly (HP:0004481)2.02901335
109Gait imbalance (HP:0002141)2.02778523
110Polyuria (HP:0000103)2.02121485
111Focal dystonia (HP:0004373)2.01509610
112Agitation (HP:0000713)2.01310371
113Craniofacial dystonia (HP:0012179)2.01307511
114Epileptic encephalopathy (HP:0200134)2.00371202
115Elevated hepatic transaminases (HP:0002910)1.99672894
116Long foot (HP:0001833)1.99488282
117Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98603218
118IgM deficiency (HP:0002850)1.96757914
119CNS demyelination (HP:0007305)1.96601870
120Gliosis (HP:0002171)1.96563828
121Renal cortical cysts (HP:0000803)1.96490953
122Myokymia (HP:0002411)1.95133944
123Status epilepticus (HP:0002133)1.93370511
124Gaze-evoked nystagmus (HP:0000640)1.92927869
125Neonatal hypoglycemia (HP:0001998)1.92701852
126Tachypnea (HP:0002789)1.92277168
127Abnormal social behavior (HP:0012433)1.91835442
128Impaired social interactions (HP:0000735)1.91835442
129Proximal tubulopathy (HP:0000114)1.90173012
130Patellar aplasia (HP:0006443)1.89053144
131Increased circulating renin level (HP:0000848)1.88750846
132Chronic hepatic failure (HP:0100626)1.87744616
133Lipid accumulation in hepatocytes (HP:0006561)1.87699885
134Retinal atrophy (HP:0001105)1.86080918
135Hypokalemic alkalosis (HP:0001949)1.86046838
136Hemiparesis (HP:0001269)1.85960990
137Congenital primary aphakia (HP:0007707)1.85915518
138Leukodystrophy (HP:0002415)1.85547542
139Growth hormone excess (HP:0000845)1.85460461
140Acute lymphatic leukemia (HP:0006721)1.85308370
141Xanthomatosis (HP:0000991)1.84618544
142Stomach cancer (HP:0012126)1.84583157
143Focal seizures (HP:0007359)1.84503611
144Cerebral hemorrhage (HP:0001342)1.83347325
145Bony spicule pigmentary retinopathy (HP:0007737)1.82705539
146Severe global developmental delay (HP:0011344)1.81831146
147Emotional lability (HP:0000712)1.80003657
148Severe muscular hypotonia (HP:0006829)1.77910536
149Degeneration of the lateral corticospinal tracts (HP:0002314)1.77194957
150Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77194957
151Aplasia/Hypoplasia of the spleen (HP:0010451)1.76912608
152Hypoplasia of the pons (HP:0012110)1.76497357
153Abnormal respiratory epithelium morphology (HP:0012253)1.76287597
154Abnormal respiratory motile cilium morphology (HP:0005938)1.76287597
155Abnormality of B cell number (HP:0010975)1.75212842
156Epidermoid cyst (HP:0200040)1.74177576
157Thrombocytosis (HP:0001894)1.74023352
158Metabolic alkalosis (HP:0200114)1.73900737
159Microvesicular hepatic steatosis (HP:0001414)1.73854661
160Aplasia/Hypoplasia of the patella (HP:0006498)1.73824574
161Tinnitus (HP:0000360)1.72902382
162Abnormal urine output (HP:0012590)1.72340985
163Hypoproteinemia (HP:0003075)1.72307638
164Large eyes (HP:0001090)1.72105727
165Chromsome breakage (HP:0040012)1.71767973
166Loss of speech (HP:0002371)1.70191190
167Pendular nystagmus (HP:0012043)1.70138615
168Spastic paraparesis (HP:0002313)1.69972334
169Torticollis (HP:0000473)1.69585159
170Severe combined immunodeficiency (HP:0004430)1.68569719
171Tented upper lip vermilion (HP:0010804)1.68559275
172Reticulocytopenia (HP:0001896)1.68432700
173Clitoromegaly (HP:0000057)1.66976728
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66968681
175Abnormality of cochlea (HP:0000375)1.66850180
176Hypoplastic labia majora (HP:0000059)1.66672026
177Abnormality of vitamin B metabolism (HP:0004340)1.64055025
178Abnormality of renal excretion (HP:0011036)1.63415786
179Poor coordination (HP:0002370)1.62947708
180Asplenia (HP:0001746)1.62618146
181Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61863248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.02891436
2WNK44.01980970
3BCKDK3.92573228
4INSRR3.75052783
5TAOK33.30030368
6STK392.67448118
7MAP3K122.58959103
8MAP4K12.54885693
9CDK192.46960481
10WNK32.35307747
11KIT2.34424872
12TNIK2.21938852
13PINK12.14588296
14PRPF4B2.06021731
15MAP2K72.04042665
16CAMKK21.96701647
17CASK1.91654067
18STK161.91274187
19BMPR21.88159732
20MAP4K21.87176269
21DAPK21.84692522
22BMPR1B1.78101569
23PASK1.73711150
24CSF1R1.66064589
25DAPK11.65979488
26TRIB31.63231514
27TLK11.60902262
28RIPK41.58202493
29ZAK1.50409316
30TNK21.49025827
31CCNB11.44956763
32SYK1.44698361
33EEF2K1.44530389
34CAMK1D1.43365102
35ADRBK21.42823359
36SIK21.41859108
37MINK11.41531443
38SIK11.40471950
39SIK31.40440766
40FGFR21.39645603
41PDK21.38299464
42MARK11.37322660
43GRK11.36632340
44EPHA41.34460659
45MAP3K21.33242595
46MAP2K41.24438701
47CSNK1G21.24192696
48MAPK131.23425407
49PDK41.18915245
50PDK31.18915245
51MAPKAPK51.17163467
52CSNK1G31.14222905
53NME11.14222630
54MAP2K61.13813433
55ZAP701.13186656
56FLT31.11520785
57PNCK1.10389176
58TGFBR21.09825148
59AKT31.07689960
60MAP3K41.07371164
61FES1.06911072
62SGK2231.06360782
63SGK4941.06360782
64MARK21.01015089
65NTRK31.00650256
66TXK0.99865861
67MAPK40.99267920
68BTK0.97774813
69CAMK10.97543948
70NUAK10.97383958
71TEC0.97344279
72CDK50.97268866
73PIM20.96667306
74MAP3K60.94554482
75CAMKK10.91708780
76GRK50.90914963
77LMTK20.89080311
78RPS6KB20.88890837
79GRK60.84281715
80TGFBR10.82995675
81SGK20.82139526
82WNK10.81743127
83ERN10.81496199
84MAP3K110.81475089
85MAPK120.81474580
86PRKCH0.81024054
87CSNK1A1L0.78008088
88ITK0.75506991
89NTRK20.74676104
90PRKAA10.73684742
91PAK30.73636794
92NEK20.73577272
93ILK0.72687223
94CAMK1G0.72375256
95MAP3K70.71772056
96PDK10.70520277
97JAK30.70492446
98KSR10.69834484
99PRKCQ0.69409386
100MAPK110.69233197
101CSNK1G10.68922743
102MAPK150.68858110
103IKBKE0.68153081
104MAP3K130.66569979
105TYK20.65548001
106TBK10.64987932
107MAP2K20.64701689
108MAP2K10.63263131
109MAP2K30.62291052
110IKBKB0.60605720
111ATR0.59702642
112RPS6KA20.59046054
113LRRK20.58694902
114ACVR1B0.57514199
115OXSR10.57371586
116IRAK40.56758148
117TIE10.55952944
118ADRBK10.55167889
119PRKCG0.54005430
120DYRK20.53868850
121SGK30.53712173
122LCK0.52386586
123RPS6KB10.50721783
124PIK3CA0.50628526
125PRKAA20.50623971
126ERBB20.49912387
127BRSK20.49055228
128KSR20.48738149
129MAPKAPK30.48334299
130UHMK10.48098614
131LYN0.47632850
132MYLK0.47484992
133PDPK10.45659927
134PRKACG0.45255272
135CDK180.44854740
136STK110.44227727
137BRSK10.44213158
138CHUK0.43642243
139PTK2B0.43133366
140PAK60.43073064
141PRKCZ0.42519232
142CDK140.42217966
143CDK150.41644814
144CDK11A0.39337445
145RAF10.37819964
146CSNK1D0.36645264
147WEE10.35377390
148PHKG20.35335302
149PHKG10.35335302
150CAMK40.35219598
151PIM10.34703817
152EIF2AK30.32754860
153STK240.32458192

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.86789347
2Propanoate metabolism_Homo sapiens_hsa006404.27711492
3Fatty acid degradation_Homo sapiens_hsa000713.89250829
4Fatty acid metabolism_Homo sapiens_hsa012123.67188569
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.46661509
6Fatty acid elongation_Homo sapiens_hsa000623.30208472
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.92380078
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.81508727
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75645150
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.70787933
11Pyruvate metabolism_Homo sapiens_hsa006202.62747637
12Linoleic acid metabolism_Homo sapiens_hsa005912.60395080
13PPAR signaling pathway_Homo sapiens_hsa033202.52080013
14Phototransduction_Homo sapiens_hsa047442.50194300
15Butanoate metabolism_Homo sapiens_hsa006502.40103671
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28791872
17Homologous recombination_Homo sapiens_hsa034402.27972259
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16763597
19Carbon metabolism_Homo sapiens_hsa012001.96185198
20Fatty acid biosynthesis_Homo sapiens_hsa000611.92724597
21Peroxisome_Homo sapiens_hsa041461.89654682
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.86266254
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66198047
24Fat digestion and absorption_Homo sapiens_hsa049751.66072682
25Fanconi anemia pathway_Homo sapiens_hsa034601.64233264
26Ether lipid metabolism_Homo sapiens_hsa005651.57768905
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54066504
28Selenocompound metabolism_Homo sapiens_hsa004501.52245331
29beta-Alanine metabolism_Homo sapiens_hsa004101.51661131
30Chemical carcinogenesis_Homo sapiens_hsa052041.40685166
31Non-homologous end-joining_Homo sapiens_hsa034501.38830452
32One carbon pool by folate_Homo sapiens_hsa006701.31973622
33Protein export_Homo sapiens_hsa030601.30614101
34Basal transcription factors_Homo sapiens_hsa030221.30321885
35Tryptophan metabolism_Homo sapiens_hsa003801.29390537
36Glycerolipid metabolism_Homo sapiens_hsa005611.27144327
37Nitrogen metabolism_Homo sapiens_hsa009101.26092011
38Synaptic vesicle cycle_Homo sapiens_hsa047211.25726728
39Regulation of autophagy_Homo sapiens_hsa041401.25153007
40Sulfur relay system_Homo sapiens_hsa041221.24932443
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24322318
42Oxidative phosphorylation_Homo sapiens_hsa001901.23519378
43Ribosome_Homo sapiens_hsa030101.22790517
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20246916
45Retinol metabolism_Homo sapiens_hsa008301.19833705
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19253979
47Vitamin digestion and absorption_Homo sapiens_hsa049771.17270052
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17032119
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.16289937
50Parkinsons disease_Homo sapiens_hsa050121.16019188
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02725139
52Taste transduction_Homo sapiens_hsa047421.01673342
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01445330
54Olfactory transduction_Homo sapiens_hsa047400.99463313
55RNA polymerase_Homo sapiens_hsa030200.98493254
56Biosynthesis of amino acids_Homo sapiens_hsa012300.91251026
57Primary immunodeficiency_Homo sapiens_hsa053400.89349290
58Morphine addiction_Homo sapiens_hsa050320.88341138
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87209744
60Arachidonic acid metabolism_Homo sapiens_hsa005900.86785175
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86676330
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84846439
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83867059
64Tyrosine metabolism_Homo sapiens_hsa003500.83311668
65Alzheimers disease_Homo sapiens_hsa050100.82613402
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.81942008
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81042749
68Pentose phosphate pathway_Homo sapiens_hsa000300.80456013
69Circadian rhythm_Homo sapiens_hsa047100.79411547
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79067311
71Ovarian steroidogenesis_Homo sapiens_hsa049130.72527475
72RNA degradation_Homo sapiens_hsa030180.72284522
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71885130
74Collecting duct acid secretion_Homo sapiens_hsa049660.71740554
75Circadian entrainment_Homo sapiens_hsa047130.71655373
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70544728
77Glutamatergic synapse_Homo sapiens_hsa047240.70297737
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70271591
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68423143
80GABAergic synapse_Homo sapiens_hsa047270.66892613
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.66745908
82Sulfur metabolism_Homo sapiens_hsa009200.65639367
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65313623
84Purine metabolism_Homo sapiens_hsa002300.62014232
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59007678
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.58899039
87Renin secretion_Homo sapiens_hsa049240.57888312
88Nicotine addiction_Homo sapiens_hsa050330.57017134
89AMPK signaling pathway_Homo sapiens_hsa041520.56459589
90Vitamin B6 metabolism_Homo sapiens_hsa007500.55808468
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54797422
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54422700
93Glucagon signaling pathway_Homo sapiens_hsa049220.53997438
94Type II diabetes mellitus_Homo sapiens_hsa049300.52745221
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.52694130
96Long-term depression_Homo sapiens_hsa047300.52636201
97Caffeine metabolism_Homo sapiens_hsa002320.52537919
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50461506
99Metabolic pathways_Homo sapiens_hsa011000.50175155
100ABC transporters_Homo sapiens_hsa020100.49945592
101Folate biosynthesis_Homo sapiens_hsa007900.48527106
102Dopaminergic synapse_Homo sapiens_hsa047280.48217485
103Serotonergic synapse_Homo sapiens_hsa047260.47532682
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45573055
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45238110
106Asthma_Homo sapiens_hsa053100.44659335
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43969070
108Huntingtons disease_Homo sapiens_hsa050160.42809909
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42155724
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.41247648
111Salivary secretion_Homo sapiens_hsa049700.40982671
112Type I diabetes mellitus_Homo sapiens_hsa049400.40963172
113Pancreatic secretion_Homo sapiens_hsa049720.39345108
114Insulin resistance_Homo sapiens_hsa049310.38912708
115Cocaine addiction_Homo sapiens_hsa050300.37432614
116Bile secretion_Homo sapiens_hsa049760.37313484
117Insulin signaling pathway_Homo sapiens_hsa049100.36965949
118Vibrio cholerae infection_Homo sapiens_hsa051100.36877880
119Arginine biosynthesis_Homo sapiens_hsa002200.34487391
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34055391
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.33953222
122Amphetamine addiction_Homo sapiens_hsa050310.33938438
123B cell receptor signaling pathway_Homo sapiens_hsa046620.33856718
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33269453
125Calcium signaling pathway_Homo sapiens_hsa040200.32981192
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32460221
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32183896
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32125208
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30888754
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.30098859
131Fructose and mannose metabolism_Homo sapiens_hsa000510.29625752
132Cholinergic synapse_Homo sapiens_hsa047250.28089093
133N-Glycan biosynthesis_Homo sapiens_hsa005100.28070588
134Histidine metabolism_Homo sapiens_hsa003400.27021863
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26911035
136Lysine degradation_Homo sapiens_hsa003100.23967415
137Complement and coagulation cascades_Homo sapiens_hsa046100.23634184
138Long-term potentiation_Homo sapiens_hsa047200.23468716
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22811004
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20418724
141Insulin secretion_Homo sapiens_hsa049110.18900434
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.18326395

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