LEXM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.83793716
2multicellular organism reproduction (GO:0032504)9.55676355
3binding of sperm to zona pellucida (GO:0007339)9.32947515
4cell-cell recognition (GO:0009988)9.21244135
5plasma membrane fusion (GO:0045026)9.01912006
6spermatid development (GO:0007286)8.98427292
7epithelial cilium movement (GO:0003351)8.64210073
8reproduction (GO:0000003)8.26526291
9axonemal dynein complex assembly (GO:0070286)8.23214521
10regulation of cilium movement (GO:0003352)8.17828210
11cilium or flagellum-dependent cell motility (GO:0001539)7.60033324
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.23660063
13cilium movement (GO:0003341)6.84782904
14negative regulation of inclusion body assembly (GO:0090084)6.84045450
15microtubule depolymerization (GO:0007019)6.58283189
16single fertilization (GO:0007338)6.47677935
17synaptonemal complex organization (GO:0070193)6.47001196
18piRNA metabolic process (GO:0034587)6.44264464
19male meiosis (GO:0007140)6.36794022
20protein targeting to Golgi (GO:0000042)6.30984838
21synaptonemal complex assembly (GO:0007130)6.27052840
22sperm capacitation (GO:0048240)6.26432484
23spermatogenesis (GO:0007283)6.22610782
24male gamete generation (GO:0048232)6.20803770
25establishment of protein localization to Golgi (GO:0072600)6.12280079
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.99414363
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.94877920
28organic cation transport (GO:0015695)5.89366817
29regulation of inclusion body assembly (GO:0090083)5.87612838
30rRNA methylation (GO:0031167)5.81287335
31response to pheromone (GO:0019236)5.73460600
32gamete generation (GO:0007276)5.69223761
33fertilization (GO:0009566)5.56668236
34keratinization (GO:0031424)5.23766755
35centriole replication (GO:0007099)5.23186180
36phosphatidylethanolamine biosynthetic process (GO:0006646)5.16542562
37calcium ion-dependent exocytosis (GO:0017156)5.08922524
38chromosome condensation (GO:0030261)5.04765133
39germ cell development (GO:0007281)5.02418870
40regulation of microtubule-based movement (GO:0060632)4.91145484
41ventricular system development (GO:0021591)4.85825857
42cellular process involved in reproduction in multicellular organism (GO:0022412)4.82658741
43DNA packaging (GO:0006323)4.78863877
44phosphatidylethanolamine metabolic process (GO:0046337)4.75263822
45rRNA modification (GO:0000154)4.75213746
46glycerol ether metabolic process (GO:0006662)4.74570060
47centriole assembly (GO:0098534)4.70021871
48cell recognition (GO:0008037)4.59024041
49regulation of centriole replication (GO:0046599)4.58460063
50protein localization to Golgi apparatus (GO:0034067)4.57581583
51male meiosis I (GO:0007141)4.52531701
52peptide cross-linking (GO:0018149)4.52210939
53multicellular organismal reproductive process (GO:0048609)4.49671386
54spermatid nucleus differentiation (GO:0007289)4.43705815
55ether metabolic process (GO:0018904)4.36595370
56chaperone-mediated protein complex assembly (GO:0051131)4.34642262
57DNA methylation involved in gamete generation (GO:0043046)4.32367784
58regulation of Rab GTPase activity (GO:0032313)4.28406435
59positive regulation of Rab GTPase activity (GO:0032851)4.28406435
60chromosome organization involved in meiosis (GO:0070192)4.27867345
61RNA destabilization (GO:0050779)4.25537078
62single strand break repair (GO:0000012)4.22083581
63microtubule polymerization or depolymerization (GO:0031109)4.07263334
64meiotic nuclear division (GO:0007126)4.06086471
65microtubule nucleation (GO:0007020)4.05950140
66microtubule severing (GO:0051013)3.97728084
67positive regulation of cellular amide metabolic process (GO:0034250)3.87005698
68seminiferous tubule development (GO:0072520)3.85556495
69sexual reproduction (GO:0019953)3.74501068
70meiosis I (GO:0007127)3.69141543
71cellular ketone body metabolic process (GO:0046950)3.67833127
72multicellular organismal development (GO:0007275)3.55585995
73negative regulation of DNA-templated transcription, elongation (GO:0032785)3.52315279
74negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.52315279
75protein K11-linked deubiquitination (GO:0035871)3.51577600
76macrophage activation involved in immune response (GO:0002281)3.43827425
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41921180
78negative regulation of cell killing (GO:0031342)3.41921180
79regulation of interferon-beta biosynthetic process (GO:0045357)3.39148262
80protein polyglutamylation (GO:0018095)3.39094739
81nucleus organization (GO:0006997)3.31283014
82protein refolding (GO:0042026)3.29697081
83genitalia morphogenesis (GO:0035112)3.28076832
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25871025
85meiotic cell cycle (GO:0051321)3.25776507
86left/right pattern formation (GO:0060972)3.25041246
87positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20873516
88antigen processing and presentation of endogenous antigen (GO:0019883)3.18464301
89chromatin silencing (GO:0006342)3.15541346
90regulation of spindle checkpoint (GO:0090231)3.14664505
91ketone body metabolic process (GO:1902224)3.12659276
92multicellular organismal movement (GO:0050879)3.07527510
93musculoskeletal movement (GO:0050881)3.07527510
94monoubiquitinated protein deubiquitination (GO:0035520)3.07305929
95GTP biosynthetic process (GO:0006183)3.00891767
96regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.00314190
97coenzyme catabolic process (GO:0009109)3.00217911
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96696956
99glomerular visceral epithelial cell development (GO:0072015)2.96018616
100glomerular epithelial cell development (GO:0072310)2.94505306
101regulation of beta-amyloid formation (GO:1902003)2.90293956
102UTP biosynthetic process (GO:0006228)2.90258168
103histone H3-K4 trimethylation (GO:0080182)2.88593178
104nucleoside diphosphate phosphorylation (GO:0006165)2.88547746
105regulation of transcription involved in cell fate commitment (GO:0060850)2.87307678
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85775277
107cerebral cortex radially oriented cell migration (GO:0021799)2.83252794
108leukocyte aggregation (GO:0070486)2.82677409
109DNA replication-dependent nucleosome assembly (GO:0006335)2.79931963
110DNA replication-dependent nucleosome organization (GO:0034723)2.79931963
111regulation of T cell mediated cytotoxicity (GO:0001914)2.77987756
112keratinocyte differentiation (GO:0030216)2.76781774
113carnitine transport (GO:0015879)2.76174317
114amino-acid betaine transport (GO:0015838)2.76174317
115detection of bacterium (GO:0016045)2.76146610
116nuclear pore complex assembly (GO:0051292)2.73899413
117meiotic cell cycle process (GO:1903046)2.72042839
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71622933
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.71622933
120modulation by symbiont of host immune response (GO:0052553)2.71622933
121positive regulation by symbiont of host defense response (GO:0052509)2.71622933
122modulation by symbiont of host defense response (GO:0052031)2.71622933
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71622933
124cellular response to arsenic-containing substance (GO:0071243)2.71600370
125cellular response to pH (GO:0071467)2.67742231
126protein localization to chromosome, centromeric region (GO:0071459)2.66141023
127UTP metabolic process (GO:0046051)2.65371233
128glycolytic process (GO:0006096)2.64152677
129protein complex localization (GO:0031503)2.63629689
130gene silencing by RNA (GO:0031047)2.61299809
131mitotic sister chromatid cohesion (GO:0007064)2.60756368
132detection of other organism (GO:0098543)2.60334035
133polyamine biosynthetic process (GO:0006596)2.59350313
134gene silencing (GO:0016458)2.59214210
135regulation of T-helper 2 cell differentiation (GO:0045628)2.58469276
136regulation of guanylate cyclase activity (GO:0031282)2.58257804
137negative regulation of organelle assembly (GO:1902116)2.56871456
138homeostasis of number of cells within a tissue (GO:0048873)2.56113971
139protein depolymerization (GO:0051261)2.53443123
140carnitine transmembrane transport (GO:1902603)2.52327519
141interferon-gamma secretion (GO:0072643)2.48338281
142synapsis (GO:0007129)2.47573904
143positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.46227402
144axoneme assembly (GO:0035082)2.42231357
145microtubule-based movement (GO:0007018)2.42163113
146alditol metabolic process (GO:0019400)2.40174621
147membrane protein ectodomain proteolysis (GO:0006509)2.37587147
148RNA localization (GO:0006403)2.36151156
149sperm motility (GO:0030317)12.6644137
150fusion of sperm to egg plasma membrane (GO:0007342)12.0311295
151cell wall macromolecule catabolic process (GO:0016998)11.8626733
152cell wall macromolecule metabolic process (GO:0044036)11.8626733
153acrosome reaction (GO:0007340)11.4110934
154sperm-egg recognition (GO:0035036)10.3023141
155motile cilium assembly (GO:0044458)10.1674197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.43598803
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.59529502
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.27477825
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03634660
5EZH2_22144423_ChIP-Seq_EOC_Human3.02014628
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91153232
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.86605901
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.82677391
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.65333584
10VDR_22108803_ChIP-Seq_LS180_Human2.57296459
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45148151
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13008681
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07798842
14RUNX_20019798_ChIP-Seq_JUKART_Human1.84453639
15TCF4_18268006_ChIP-ChIP_LS174T_Human1.84323117
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83230319
17FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81548067
18KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.79531771
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76427081
20ZNF274_21170338_ChIP-Seq_K562_Hela1.71295331
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70634354
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.68973723
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66818938
24TAF2_19829295_ChIP-Seq_ESCs_Human1.66424076
25CEBPB_22108803_ChIP-Seq_LS180_Human1.66217347
26ERA_21632823_ChIP-Seq_H3396_Human1.66057241
27GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.65412770
28GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.65175380
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.64990859
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64946526
31BCL6_27268052_Chip-Seq_Bcells_Human1.64598712
32STAT1_17558387_ChIP-Seq_HELA_Human1.64577166
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.64262443
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59689648
35BCOR_27268052_Chip-Seq_Bcells_Human1.59538539
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59088173
37E2F1_20622854_ChIP-Seq_HELA_Human1.57191084
38RAC3_21632823_ChIP-Seq_H3396_Human1.57026952
39HNFA_21074721_ChIP-Seq_CACO-2_Human1.56515638
40RBPJ_21746931_ChIP-Seq_IB4_Human1.54477232
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.54382181
42CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.51813555
43GATA6_21074721_ChIP-Seq_CACO-2_Human1.50621565
44SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.50255563
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50190926
46MYC_19829295_ChIP-Seq_ESCs_Human1.49990835
47ERG_20517297_ChIP-Seq_VCAP_Human1.49036211
48SMC4_20622854_ChIP-Seq_HELA_Human1.48992788
49SOX2_22085726_ChIP-Seq_NPCs_Mouse1.47709676
50CTCF_27219007_Chip-Seq_Bcells_Human1.47525118
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47464700
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.45571191
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.44684970
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.41970946
55REST_21632747_ChIP-Seq_MESCs_Mouse1.40954325
56LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39054302
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.38105437
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.38002775
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37553953
60GATA3_21867929_ChIP-Seq_CD8_Mouse1.36540514
61GATA1_19941826_ChIP-Seq_K562_Human1.35724544
62PHF8_20622854_ChIP-Seq_HELA_Human1.35519868
63TP63_22573176_ChIP-Seq_HFKS_Human1.35392364
64DROSHA_22980978_ChIP-Seq_HELA_Human1.35276725
65FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35063401
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34725799
67AR_21572438_ChIP-Seq_LNCaP_Human1.32870128
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32572933
69KLF5_25053715_ChIP-Seq_YYC3_Human1.31687031
70VDR_24787735_ChIP-Seq_THP-1_Human1.31302299
71AR_25329375_ChIP-Seq_VCAP_Human1.30666800
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30636821
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30242731
74P68_20966046_ChIP-Seq_HELA_Human1.29804911
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29251245
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29204287
77MYB_26560356_Chip-Seq_TH2_Human1.29171299
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.28890707
79OCT4_20526341_ChIP-Seq_ESCs_Human1.28685475
80ER_23166858_ChIP-Seq_MCF-7_Human1.27972403
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27756163
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27329306
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26789209
84SMRT_27268052_Chip-Seq_Bcells_Human1.26590245
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.26184646
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25955853
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.25610571
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24336315
89CTCF_20526341_ChIP-Seq_ESCs_Human1.23780216
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.22763048
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22251134
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21651426
93P300_27268052_Chip-Seq_Bcells_Human1.21383519
94SA1_27219007_Chip-Seq_Bcells_Human1.21224415
95CBP_20019798_ChIP-Seq_JUKART_Human1.20448834
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20448834
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19239141
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18808861
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18808861
100SPI1_23127762_ChIP-Seq_K562_Human1.18747935
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17911155
102GATA3_21867929_ChIP-Seq_TH1_Mouse1.17556542
103FLI1_21867929_ChIP-Seq_CD8_Mouse1.17037146
104KLF4_19829295_ChIP-Seq_ESCs_Human1.16261342
105P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15227871
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15028919
107PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.14719671
108AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13889061
109GATA1_19941827_ChIP-Seq_MEL86_Mouse1.13380904
110FOXH1_21741376_ChIP-Seq_ESCs_Human1.11419336
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10798688
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.09835145
113GF1_26923725_Chip-Seq_HPCs_Mouse1.09702455
114GATA3_27048872_Chip-Seq_THYMUS_Human1.09690868
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09404208
116FUS_26573619_Chip-Seq_HEK293_Human1.08958608
117NFYA_21822215_ChIP-Seq_K562_Human1.08873767
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08753445
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.08724444
120EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08569609
121CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08534387
122EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08382411
123IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08142643
124TP63_23658742_ChIP-Seq_EP156T_Human1.08109725
125FOXH1_21741376_ChIP-Seq_EPCs_Human1.07214626
126GATA3_26560356_Chip-Seq_TH2_Human1.07144638
127SPI1_26923725_Chip-Seq_HPCs_Mouse1.07082294
128GF1B_26923725_Chip-Seq_HPCs_Mouse1.06945590
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.06906238
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06201803
131RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06026640
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05693685
133NFYB_21822215_ChIP-Seq_K562_Human1.05072769
134KDM2B_26808549_Chip-Seq_REH_Human1.04025415
135RXR_22108803_ChIP-Seq_LS180_Human1.03849467
136P53_21459846_ChIP-Seq_SAOS-2_Human1.03811256
137CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03448588
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.03258114
139E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02897318
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02805970
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01792414
142MYC_27129775_Chip-Seq_CORNEA_Mouse1.00619139
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.99818023
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99429343
145TAF15_26573619_Chip-Seq_HEK293_Human0.98514255
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.97459185
147STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97213238
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96716851
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96193729
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.94772932
151RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94539577
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94397355
153SOX9_26525672_Chip-Seq_HEART_Mouse0.93569838
154TBL1_22424771_ChIP-Seq_293T_Human0.92047116
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91724368
156NANOG_20526341_ChIP-Seq_ESCs_Human0.91570379
157SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89712435
158RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89386870
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88819182
160LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88578985
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87241550
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87209524
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86695523
164ETV1_20927104_ChIP-Seq_GIST48_Human0.86338944
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86224837
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.85551332
167PHF8_20622853_ChIP-Seq_HELA_Human0.84159686
168CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84018383
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83881515
170E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83397806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.62056558
2MP0001929_abnormal_gametogenesis5.25936865
3MP0005377_hearing/vestibular/ear_phenot5.09568623
4MP0003878_abnormal_ear_physiology5.09568623
5MP0008877_abnormal_DNA_methylation4.14494772
6MP0002210_abnormal_sex_determination3.30123272
7MP0002161_abnormal_fertility/fecundity3.20093346
8MP0001145_abnormal_male_reproductive2.89145175
9MP0002132_abnormal_respiratory_system2.61426683
10MP0010234_abnormal_vibrissa_follicle2.60949629
11MP0000653_abnormal_sex_gland2.52827260
12MP0005670_abnormal_white_adipose2.41946549
13MP0005623_abnormal_meninges_morphology2.20808382
14MP0002653_abnormal_ependyma_morphology2.13663194
15MP0000678_abnormal_parathyroid_gland2.11966365
16MP0005451_abnormal_body_composition2.06179588
17MP0003011_delayed_dark_adaptation2.03936599
18MP0005410_abnormal_fertilization14.6579093
19MP0005409_darkened_coat_color1.73707056
20MP0005671_abnormal_response_to1.62536261
21MP0005083_abnormal_biliary_tract1.57854755
22MP0008057_abnormal_DNA_replication1.56678674
23MP0003436_decreased_susceptibility_to1.55141517
24MP0001835_abnormal_antigen_presentation1.53431031
25MP0003303_peritoneal_inflammation1.51866850
26MP0001348_abnormal_lacrimal_gland1.50037054
27MP0004233_abnormal_muscle_weight1.48381743
28MP0003724_increased_susceptibility_to1.48074544
29MP0002160_abnormal_reproductive_system1.45616128
30MP0001800_abnormal_humoral_immune1.39896338
31MP0003329_amyloid_beta_deposits1.38563585
32MP0001666_abnormal_nutrient_absorption1.38146624
33MP0000470_abnormal_stomach_morphology1.35937782
34MP0006082_CNS_inflammation1.34238390
35MP0004957_abnormal_blastocyst_morpholog1.32515272
36MP0005365_abnormal_bile_salt1.31619301
37MP0005025_abnormal_response_to1.26757895
38MP0009785_altered_susceptibility_to1.21558317
39MP0000920_abnormal_myelination1.20286131
40MP0000685_abnormal_immune_system1.19912425
41MP0002282_abnormal_trachea_morphology1.17534871
42MP0004883_abnormal_blood_vessel1.16355473
43MP0003718_maternal_effect1.16067430
44MP0005248_abnormal_Harderian_gland1.15241871
45MP0005085_abnormal_gallbladder_physiolo1.14991908
46MP0002736_abnormal_nociception_after1.14168158
47MP0001968_abnormal_touch/_nociception1.14113734
48MP0002723_abnormal_immune_serum1.13843938
49MP0002405_respiratory_system_inflammati1.11144156
50MP0003646_muscle_fatigue1.09888247
51MP0002419_abnormal_innate_immunity1.09390276
52MP0008058_abnormal_DNA_repair1.07741777
53MP0001730_embryonic_growth_arrest1.07733607
54MP0000462_abnormal_digestive_system1.07558546
55MP0009333_abnormal_splenocyte_physiolog1.07473471
56MP0003763_abnormal_thymus_physiology1.06533062
57MP0004947_skin_inflammation1.05788371
58MP0002249_abnormal_larynx_morphology1.04734410
59MP0002452_abnormal_antigen_presenting1.03238261
60MP0002139_abnormal_hepatobiliary_system1.01041594
61MP0005000_abnormal_immune_tolerance1.00916147
62MP0000427_abnormal_hair_cycle0.99812227
63MP0003879_abnormal_hair_cell0.99359200
64MP0001984_abnormal_olfaction0.98371441
65MP0010094_abnormal_chromosome_stability0.97287296
66MP0006292_abnormal_olfactory_placode0.95445380
67MP0001790_abnormal_immune_system0.94319794
68MP0005387_immune_system_phenotype0.94319794
69MP0005379_endocrine/exocrine_gland_phen0.94167319
70MP0005636_abnormal_mineral_homeostasis0.94021605
71MP0009115_abnormal_fat_cell0.94005468
72MP0002098_abnormal_vibrissa_morphology0.90764084
73MP0005501_abnormal_skin_physiology0.90703737
74MP0008875_abnormal_xenobiotic_pharmacok0.90285616
75MP0003136_yellow_coat_color0.89902756
76MP0006035_abnormal_mitochondrial_morpho0.89861430
77MP0003806_abnormal_nucleotide_metabolis0.89719275
78MP0002420_abnormal_adaptive_immunity0.89461522
79MP0003828_pulmonary_edema0.89196051
80MP0001661_extended_life_span0.88729546
81MP0001819_abnormal_immune_cell0.88628549
82MP0003111_abnormal_nucleus_morphology0.87488348
83MP0009046_muscle_twitch0.86526277
84MP0009053_abnormal_anal_canal0.86478169
85MP0005164_abnormal_response_to0.85337907
86MP0005174_abnormal_tail_pigmentation0.84253521
87MP0010329_abnormal_lipoprotein_level0.83958239
88MP0005423_abnormal_somatic_nervous0.81092103
89MP0005166_decreased_susceptibility_to0.80811652
90MP0008995_early_reproductive_senescence0.79168194
91MP0009764_decreased_sensitivity_to0.79042763
92MP0001851_eye_inflammation0.77883197
93MP0008789_abnormal_olfactory_epithelium0.77381121
94MP0010155_abnormal_intestine_physiology0.76634033
95MP0005666_abnormal_adipose_tissue0.75540498
96MP0001533_abnormal_skeleton_physiology0.74132102
97MP0008932_abnormal_embryonic_tissue0.73738755
98MP0003632_abnormal_nervous_system0.73687005
99MP0008469_abnormal_protein_level0.73663453
100MP0004264_abnormal_extraembryonic_tissu0.72893873
101MP0003077_abnormal_cell_cycle0.72686054
102MP0001764_abnormal_homeostasis0.72301814
103MP0003115_abnormal_respiratory_system0.72165770
104MP0001293_anophthalmia0.72156778
105MP0001501_abnormal_sleep_pattern0.71716641
106MP0001986_abnormal_taste_sensitivity0.69533655
107MP0004134_abnormal_chest_morphology0.69407555
108MP0005253_abnormal_eye_physiology0.68895223
109MP0004043_abnormal_pH_regulation0.68502265
110MP0002136_abnormal_kidney_physiology0.68148813
111MP0005376_homeostasis/metabolism_phenot0.67994879
112MP0003183_abnormal_peptide_metabolism0.67935063
113MP0005389_reproductive_system_phenotype0.67582391
114MP0002138_abnormal_hepatobiliary_system0.66956739
115MP0000358_abnormal_cell_content/0.66792263
116MP0001765_abnormal_ion_homeostasis0.66130706
117MP0005395_other_phenotype0.66125167
118MP0002095_abnormal_skin_pigmentation0.65411977
119MP0002102_abnormal_ear_morphology0.65172987
120MP0000604_amyloidosis0.65073648
121MP0001216_abnormal_epidermal_layer0.64821308
122MP0002084_abnormal_developmental_patter0.64708166
123MP0002398_abnormal_bone_marrow0.64528430
124MP0004270_analgesia0.63649957
125MP0000716_abnormal_immune_system0.63317895
126MP0002234_abnormal_pharynx_morphology0.62856866
127MP0000465_gastrointestinal_hemorrhage0.62029252
128MP0005171_absent_coat_pigmentation0.61014964
129MP0001529_abnormal_vocalization0.60871777
130MP0004036_abnormal_muscle_relaxation0.60230808
131MP0002085_abnormal_embryonic_tissue0.60214098
132MP0001697_abnormal_embryo_size0.59868006
133MP0002272_abnormal_nervous_system0.57843286
134MP0005310_abnormal_salivary_gland0.57761414
135MP0005380_embryogenesis_phenotype0.56677929
136MP0001672_abnormal_embryogenesis/_devel0.56677929
137MP0006072_abnormal_retinal_apoptosis0.56596574
138MP0002089_abnormal_postnatal_growth/wei0.56084325
139MP0003861_abnormal_nervous_system0.55556331
140MP0009697_abnormal_copulation0.55349844
141MP0005551_abnormal_eye_electrophysiolog0.54874789
142MP0001727_abnormal_embryo_implantation0.54506293
143MP0002269_muscular_atrophy0.54399392
144MP0004133_heterotaxia0.53924252
145MP0003690_abnormal_glial_cell0.53598508
146MP0002295_abnormal_pulmonary_circulatio0.52789478
147MP0001324_abnormal_eye_pigmentation0.52567254
148MP0004742_abnormal_vestibular_system0.52076218
149MP0001485_abnormal_pinna_reflex0.51771931
150MP0001486_abnormal_startle_reflex0.51530755
151MP0002080_prenatal_lethality0.51388413
152MP0005391_vision/eye_phenotype0.50737800
153MP0003699_abnormal_female_reproductive0.49223535
154MP0000350_abnormal_cell_proliferation0.48456805
155MP0003634_abnormal_glial_cell0.47935128
156MP0004197_abnormal_fetal_growth/weight/0.47839867
157MP0004185_abnormal_adipocyte_glucose0.47291480
158MP0003984_embryonic_growth_retardation0.47186604
159MP0003868_abnormal_feces_composition0.46362898
160MP0002092_abnormal_eye_morphology0.44208324
161MP0002152_abnormal_brain_morphology0.43816478
162MP0009765_abnormal_xenobiotic_induced0.43809081
163MP0006036_abnormal_mitochondrial_physio0.43289982
164MP0002088_abnormal_embryonic_growth/wei0.43270364
165MP0000313_abnormal_cell_death0.41861497
166MP0002229_neurodegeneration0.41847899
167MP0005647_abnormal_sex_gland0.41768554
168MP0002752_abnormal_somatic_nervous0.41726519
169MP0000467_abnormal_esophagus_morphology0.41639488
170MP0003693_abnormal_embryo_hatching0.41071874
171MP0002796_impaired_skin_barrier0.40736455
172MP0005195_abnormal_posterior_eye0.40687163
173MP0000955_abnormal_spinal_cord0.37249971
174MP0002873_normal_phenotype0.36084474
175MP0002169_no_abnormal_phenotype0.35596397
176MP0003890_abnormal_embryonic-extraembry0.35540054
177MP0003950_abnormal_plasma_membrane0.35105653
178MP0004885_abnormal_endolymph0.34935047

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.17902258
2Abnormal respiratory motile cilium morphology (HP:0005938)8.17902258
3Abnormal respiratory motile cilium physiology (HP:0012261)8.07413737
4Chronic bronchitis (HP:0004469)6.45266731
5Rhinitis (HP:0012384)6.42925247
6Infertility (HP:0000789)6.21537219
7Abnormal ciliary motility (HP:0012262)6.14282876
8Nasal polyposis (HP:0100582)5.19448166
9Male infertility (HP:0003251)4.87576293
10Severe visual impairment (HP:0001141)4.84956567
11Chronic hepatic failure (HP:0100626)4.43437082
12Asymmetric septal hypertrophy (HP:0001670)4.42142430
13Pustule (HP:0200039)4.36304026
14Hyperkalemia (HP:0002153)4.13845836
15Abnormality of the nasal mucosa (HP:0000433)4.11122440
16Increased IgE level (HP:0003212)4.04813573
17Hemorrhage of the eye (HP:0011885)3.83448205
18Eczematoid dermatitis (HP:0000976)3.74807277
19Bronchitis (HP:0012387)3.74056552
20Enlarged epiphyses (HP:0010580)3.69561040
21Bronchiectasis (HP:0002110)3.59674914
22Impulsivity (HP:0100710)3.55835797
23Bony spicule pigmentary retinopathy (HP:0007737)3.37550048
24Attenuation of retinal blood vessels (HP:0007843)3.35933973
25Nephronophthisis (HP:0000090)3.34502816
26Abnormal spermatogenesis (HP:0008669)3.33798920
27Cone-rod dystrophy (HP:0000548)3.31534286
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.20074748
29Breast hypoplasia (HP:0003187)3.06792464
30Stomach cancer (HP:0012126)3.02470853
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.00924603
32Tubulointerstitial nephritis (HP:0001970)2.97704861
33Sensory axonal neuropathy (HP:0003390)2.95577637
34Amelogenesis imperfecta (HP:0000705)2.95286767
35Hypoplasia of the thymus (HP:0000778)2.94197442
36Hypochromic microcytic anemia (HP:0004840)2.87784944
37Resting tremor (HP:0002322)2.87387897
38Abnormality of macular pigmentation (HP:0008002)2.79118058
39Supernumerary ribs (HP:0005815)2.72050789
40Recurrent otitis media (HP:0000403)2.71400364
41Recurrent sinusitis (HP:0011108)2.62476477
42Thick nail (HP:0001805)2.62162391
43Double outlet right ventricle (HP:0001719)2.56508750
44Congenital malformation of the right heart (HP:0011723)2.56508750
45Postural instability (HP:0002172)2.50676749
46Oral leukoplakia (HP:0002745)2.48951737
47Absent hand (HP:0004050)2.48634329
48IgM deficiency (HP:0002850)2.42947057
49Increased IgM level (HP:0003496)2.41615040
50Supernumerary bones of the axial skeleton (HP:0009144)2.40848720
51Osteomalacia (HP:0002749)2.37661186
52Abnormality of the renal medulla (HP:0100957)2.37369786
53Spastic tetraparesis (HP:0001285)2.35538284
54Seborrheic dermatitis (HP:0001051)2.34357189
55Hypoplastic nipples (HP:0002557)2.33891463
56Multiple enchondromatosis (HP:0005701)2.30990804
57Abnormal gallbladder physiology (HP:0012438)2.30144485
58Cholecystitis (HP:0001082)2.30144485
59Hyperactive renin-angiotensin system (HP:0000841)2.30129024
60Premature loss of primary teeth (HP:0006323)2.23269807
61Recurrent bacterial skin infections (HP:0005406)2.23121282
62Myositis (HP:0100614)2.22416661
63Hyponatremia (HP:0002902)2.22263130
64Peripheral hypomyelination (HP:0007182)2.21121134
65Gingivitis (HP:0000230)2.17590164
66Medial flaring of the eyebrow (HP:0010747)2.16689199
67Periodontitis (HP:0000704)2.14260891
68T lymphocytopenia (HP:0005403)2.13091378
69Retrobulbar optic neuritis (HP:0100654)2.11609825
70Optic neuritis (HP:0100653)2.11609825
71Orchitis (HP:0100796)2.11302673
72Widely patent fontanelles and sutures (HP:0004492)2.10527160
73Abnormality of dental color (HP:0011073)2.10489589
74Azoospermia (HP:0000027)2.09987359
75Villous atrophy (HP:0011473)2.09900913
76Abnormality of small intestinal villus morphology (HP:0011472)2.09900913
77Hypochromic anemia (HP:0001931)2.08906134
78Truncal obesity (HP:0001956)2.08346236
79Oligodactyly (hands) (HP:0001180)2.06869013
80Abnormality of potassium homeostasis (HP:0011042)2.06707927
81Progressive sensorineural hearing impairment (HP:0000408)2.06145346
82Abnormality of T cell number (HP:0011839)2.05864726
83Intellectual disability, moderate (HP:0002342)2.05747104
84Tubulointerstitial abnormality (HP:0001969)2.04567637
85Abnormality of midbrain morphology (HP:0002418)2.04448026
86Molar tooth sign on MRI (HP:0002419)2.04448026
87Anhidrosis (HP:0000970)2.03137446
88Gastrointestinal infarctions (HP:0005244)2.02449486
89Menstrual irregularities (HP:0000858)2.02417308
90Recurrent fungal infections (HP:0002841)2.02331165
91Retinal dysplasia (HP:0007973)2.02281376
92Progressive cerebellar ataxia (HP:0002073)2.02249720
93Hemivertebrae (HP:0002937)2.02225681
94Decreased circulating renin level (HP:0003351)2.00981676
95Hypotrichosis (HP:0001006)2.00785077
96Absent/shortened dynein arms (HP:0200106)11.8236416
97Dynein arm defect of respiratory motile cilia (HP:0012255)11.8236416
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4885841
99Facial shape deformation (HP:0011334)1.99679534
100Potter facies (HP:0002009)1.99679534
101Abnormality of hair growth rate (HP:0011363)1.97898294
102Slow-growing hair (HP:0002217)1.97898294
103Abnormal delayed hypersensitivity skin test (HP:0002963)1.96758654
104Hypoalbuminemia (HP:0003073)1.94211499
105Abnormal albumin level (HP:0012116)1.94211499
106Malignant hyperthermia (HP:0002047)1.94186599
107Tubular atrophy (HP:0000092)1.93397668
108Recurrent bronchitis (HP:0002837)1.93249767
109Abnormality of macrophages (HP:0004311)1.92860037
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92260778
111Gonadotropin excess (HP:0000837)1.91360060
112Abnormal urine output (HP:0012590)1.91101655
113Dyschromatopsia (HP:0007641)1.89324116
114Aplasia/Hypoplasia of the thymus (HP:0010515)1.88758444
115Abnormality of the hepatic vasculature (HP:0006707)1.86425094
116Recurrent abscess formation (HP:0002722)1.84593291
117Congenital sensorineural hearing impairment (HP:0008527)1.83617992
118Abnormality of renal excretion (HP:0011036)1.83126009
119Oligodontia (HP:0000677)1.83038363
120Recurrent pneumonia (HP:0006532)1.81918992
121Abnormality of incisor morphology (HP:0011063)1.81626453
122Delayed epiphyseal ossification (HP:0002663)1.79245804
123Hypophosphatemic rickets (HP:0004912)1.78289014
124Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77322762
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.77322762
126Acute hepatic failure (HP:0006554)1.77158314
127Erythroderma (HP:0001019)1.75766137
128Abnormal rod and cone electroretinograms (HP:0008323)1.75453298
129Portal hypertension (HP:0001409)1.75110061
130Congenital ichthyosiform erythroderma (HP:0007431)1.74849808
131Neurofibrillary tangles (HP:0002185)1.73131648
132Hypoplastic pelvis (HP:0008839)1.70559048
133Gait imbalance (HP:0002141)1.70125368
134Congenital primary aphakia (HP:0007707)1.66272895
135Cerebral hypomyelination (HP:0006808)1.62868827
136Choroideremia (HP:0001139)1.62591528
137Decreased central vision (HP:0007663)1.59445085
138Vaginal atresia (HP:0000148)1.58085853
139Heterotopia (HP:0002282)1.57559766
140Aplasia/Hypoplasia of the lens (HP:0008063)1.56566626
141Ridged nail (HP:0001807)1.54566675
142Abnormality of the lower motor neuron (HP:0002366)1.52039895
143Easy fatigability (HP:0003388)1.50097535
144Genital tract atresia (HP:0001827)1.47884270
145Bell-shaped thorax (HP:0001591)1.47616129
146Absent epiphyses (HP:0010577)1.47011492
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.47011492
148Abnormality of the corticospinal tract (HP:0002492)1.46374029
149Deep palmar crease (HP:0006191)1.46210320
150Abnormality of the parathyroid morphology (HP:0011766)1.44582177
151Conical tooth (HP:0000698)1.43454740
152Cleft eyelid (HP:0000625)1.42643538
153Transposition of the great arteries (HP:0001669)1.40959216
154Abnormal connection of the cardiac segments (HP:0011545)1.40959216
155Abnormal ventriculo-arterial connection (HP:0011563)1.40959216
156Cerebral inclusion bodies (HP:0100314)1.40599012
157Oligodactyly (HP:0012165)1.35881397
158Nephrogenic diabetes insipidus (HP:0009806)1.35460536
159Stage 5 chronic kidney disease (HP:0003774)1.35355159
160Poor coordination (HP:0002370)1.33652147
161Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32876170
162Facial cleft (HP:0002006)1.32334933
163Polydipsia (HP:0001959)1.32025050
164Abnormal drinking behavior (HP:0030082)1.32025050
165Postaxial hand polydactyly (HP:0001162)1.31938218
166Hemiparesis (HP:0001269)1.31783664
167Malnutrition (HP:0004395)1.31311793
168Polymicrogyria (HP:0002126)1.31024222
169Esophageal atresia (HP:0002032)1.28700241
170Short ribs (HP:0000773)1.27409029
171Oculomotor apraxia (HP:0000657)1.26544809
172Neoplasm of the oral cavity (HP:0100649)1.23885208
173Bile duct proliferation (HP:0001408)1.23806026
174Abnormal biliary tract physiology (HP:0012439)1.23806026
175Pachygyria (HP:0001302)1.23736662
176Tubulointerstitial fibrosis (HP:0005576)1.23597771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.31616967
2PDK46.31616967
3ICK5.88961582
4TESK15.18539564
5PRKD34.88333189
6WNK34.67158083
7PDK24.20782219
8BRD43.83896915
9INSRR3.21320129
10STK393.02184297
11SIK22.34584983
12TNIK2.32993904
13PLK22.20476845
14TYRO32.17588039
15PNCK2.11389055
16MAP4K22.05635447
17MAP4K11.79846791
18NUAK11.71415501
19DDR21.70013753
20PTK2B1.69456114
21WNK41.68184699
22CAMK1G1.66392735
23MST1R1.65235577
24EPHB11.60428684
25GRK61.51349290
26STK381.50249468
27BLK1.44073909
28FRK1.41360384
29PINK11.36134595
30IRAK21.34824805
31TTK1.34169424
32PIK3CG1.32234688
33IRAK11.32097772
34NEK21.30738826
35DYRK1B1.27456598
36BRSK21.23188397
37NLK1.22476390
38PKN21.17388435
39PDK11.10590274
40CDK120.99462200
41MKNK20.97131820
42WEE10.96335264
43MAP3K110.92866002
44TXK0.92469357
45OXSR10.88320776
46SGK2230.87681909
47SGK4940.87681909
48SGK20.85252614
49SGK30.83138473
50PASK0.83113880
51CHEK20.83029144
52PDPK10.82522219
53CAMK1D0.81005921
54TNK20.80392684
55BUB10.80377276
56MUSK0.79269846
57KSR20.78943252
58EPHA30.78234323
59MAP3K10.76656689
60MET0.74736158
61PKN10.73299952
62CSNK1D0.73099691
63ZAP700.71534923
64TAOK10.71239391
65DMPK0.69442356
66PRKG20.69436330
67MAP3K30.69350458
68PRKAA20.69096409
69MAPK150.67402128
70FLT30.67099820
71CASK0.67071750
72ERN10.66901191
73DYRK30.65407674
74BRSK10.64278948
75PAK40.64163563
76PLK40.63258273
77JAK30.62318685
78SYK0.62297009
79BCR0.61500485
80CLK10.61213988
81CHEK10.61022683
82PAK10.60930372
83CDK30.59768703
84IKBKE0.59745546
85STK110.59402466
86STK30.57373305
87CDK40.57349186
88TESK20.56103260
89TYK20.55671830
90MAP2K60.55616456
91WNK10.55331930
92ZAK0.52336854
93MARK30.51194623
94MST40.50991762
95EPHA20.50691026
96PAK20.46837789
97AURKA0.44571648
98BTK0.44386208
99CSK0.43191723
100MARK20.42595828
101MAP3K100.42418581
102ATM0.41829517
103ACVR1B0.40882678
104RAF10.40474406
105PRKCG0.38296449
106CDC70.37278626
107FES0.37199207
108MAPK110.36726292
109UHMK10.35689740
110HCK0.35059118
111MTOR0.33862933
112MAP3K70.32331973
113PLK10.32307052
114LYN0.32156275
115STK38L0.32001014
116RPS6KA10.30757278
117PRKG10.30714181
118CSNK2A20.30258846
119DYRK20.29326428
120MAPK80.28421547
121SGK10.27945312
122JAK20.27401268
123JAK10.26513863
124ITK0.26507708
125PRKCH0.26266972
126ROCK20.25508217
127SIK30.25273285
128CDK140.24941421
129STK100.24722394
130IKBKB0.24331348
131CAMK10.24264192
132ROCK10.23557172
133NEK90.23106249
134FGR0.22949619
135CAMKK10.22134536
136CSNK1E0.21886472
137CDK150.21810878
138FGFR20.20907540
139NEK60.20804187
140INSR0.20521393
141YES10.20483307
142CDK70.20367296
143IRAK40.20239123
144CAMKK20.19911389
145MAPK130.19787847
146PRKCQ0.19767995
147CDK11A0.19762438
148CDK20.19316313
149LATS10.19204204
150GSK3B0.18041044
151STK40.17611860
152PDGFRB0.17109483
153RIPK40.16549167
154CDK10.15933270
155CDK180.15913764
156PRKCI0.15884533
157TLK10.14435878
158PAK60.14356082
159PRPF4B0.14154316
160PIM10.13603008
161EIF2AK30.13369155
162MAP3K80.12179031
163PRKCZ0.12145293
164MAP3K20.11907309

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.46317379
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.13007125
3Basal transcription factors_Homo sapiens_hsa030223.81903713
4Vitamin B6 metabolism_Homo sapiens_hsa007503.76928207
5Graft-versus-host disease_Homo sapiens_hsa053323.72358783
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.51665060
7Allograft rejection_Homo sapiens_hsa053303.05218987
8Linoleic acid metabolism_Homo sapiens_hsa005913.00825579
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91972868
10Autoimmune thyroid disease_Homo sapiens_hsa053202.90286040
11Ether lipid metabolism_Homo sapiens_hsa005652.52246107
12Type I diabetes mellitus_Homo sapiens_hsa049402.22050846
13Pyruvate metabolism_Homo sapiens_hsa006202.14367686
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14342198
15Propanoate metabolism_Homo sapiens_hsa006402.12181393
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01378043
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.99278680
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.98358088
19Viral myocarditis_Homo sapiens_hsa054161.96806036
20RNA transport_Homo sapiens_hsa030131.84837390
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79204168
22Oocyte meiosis_Homo sapiens_hsa041141.78900123
23Non-homologous end-joining_Homo sapiens_hsa034501.74344056
24Olfactory transduction_Homo sapiens_hsa047401.68230292
25Retinol metabolism_Homo sapiens_hsa008301.68059671
26Glucagon signaling pathway_Homo sapiens_hsa049221.63655178
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.62211386
28Staphylococcus aureus infection_Homo sapiens_hsa051501.61316873
29Primary immunodeficiency_Homo sapiens_hsa053401.60121220
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59770650
31Fatty acid metabolism_Homo sapiens_hsa012121.57392789
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54955221
33Fat digestion and absorption_Homo sapiens_hsa049751.52835921
34Phenylalanine metabolism_Homo sapiens_hsa003601.52113252
35Glutathione metabolism_Homo sapiens_hsa004801.48647994
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48558588
37Collecting duct acid secretion_Homo sapiens_hsa049661.45122988
38Selenocompound metabolism_Homo sapiens_hsa004501.44676956
39Influenza A_Homo sapiens_hsa051641.38410000
40Mineral absorption_Homo sapiens_hsa049781.37255295
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.35066875
42Butanoate metabolism_Homo sapiens_hsa006501.34298174
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31809724
44PPAR signaling pathway_Homo sapiens_hsa033201.31626837
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30401473
46mRNA surveillance pathway_Homo sapiens_hsa030151.30027785
47Dorso-ventral axis formation_Homo sapiens_hsa043201.27407706
48Glycerolipid metabolism_Homo sapiens_hsa005611.26719989
49Inositol phosphate metabolism_Homo sapiens_hsa005621.20388080
50Leishmaniasis_Homo sapiens_hsa051401.19102034
51Purine metabolism_Homo sapiens_hsa002301.18762636
52Carbon metabolism_Homo sapiens_hsa012001.17948048
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17021685
54Caffeine metabolism_Homo sapiens_hsa002321.11828546
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09886526
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.07154882
57Adipocytokine signaling pathway_Homo sapiens_hsa049201.06646850
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.05513074
59Huntingtons disease_Homo sapiens_hsa050161.04667186
60Cardiac muscle contraction_Homo sapiens_hsa042601.04254713
61Osteoclast differentiation_Homo sapiens_hsa043801.03069296
62Fatty acid elongation_Homo sapiens_hsa000621.02719033
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01982833
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01782678
65Taste transduction_Homo sapiens_hsa047421.00719156
66Biosynthesis of amino acids_Homo sapiens_hsa012301.00424422
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98936852
68Herpes simplex infection_Homo sapiens_hsa051680.97294391
69Steroid biosynthesis_Homo sapiens_hsa001000.95816300
70Fatty acid degradation_Homo sapiens_hsa000710.94972789
71Hedgehog signaling pathway_Homo sapiens_hsa043400.94652331
72Pyrimidine metabolism_Homo sapiens_hsa002400.93042584
73Phototransduction_Homo sapiens_hsa047440.92803421
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.90606750
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.89240094
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87759694
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.87654791
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85109522
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84840878
80Amphetamine addiction_Homo sapiens_hsa050310.84536496
81Vitamin digestion and absorption_Homo sapiens_hsa049770.83761878
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83265916
83Arachidonic acid metabolism_Homo sapiens_hsa005900.83139653
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82982332
85Spliceosome_Homo sapiens_hsa030400.82373631
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82263517
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81592061
88Histidine metabolism_Homo sapiens_hsa003400.79122337
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78999642
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78354270
91Fructose and mannose metabolism_Homo sapiens_hsa000510.78327219
92RNA polymerase_Homo sapiens_hsa030200.77875011
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.77656418
94Proteasome_Homo sapiens_hsa030500.76413726
95Measles_Homo sapiens_hsa051620.74950364
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74365316
97Chemokine signaling pathway_Homo sapiens_hsa040620.74240994
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73740758
99Tuberculosis_Homo sapiens_hsa051520.72530886
100Pentose phosphate pathway_Homo sapiens_hsa000300.71907480
101DNA replication_Homo sapiens_hsa030300.71503634
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69032757
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.68924278
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67872957
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67639291
106Type II diabetes mellitus_Homo sapiens_hsa049300.67258140
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66900905
108Estrogen signaling pathway_Homo sapiens_hsa049150.66544272
109Tyrosine metabolism_Homo sapiens_hsa003500.65686412
110Thyroid hormone synthesis_Homo sapiens_hsa049180.65418347
111Tight junction_Homo sapiens_hsa045300.64759971
112Antigen processing and presentation_Homo sapiens_hsa046120.62688926
113Systemic lupus erythematosus_Homo sapiens_hsa053220.60914497
114Epstein-Barr virus infection_Homo sapiens_hsa051690.59057896
115Axon guidance_Homo sapiens_hsa043600.56161931
116Toxoplasmosis_Homo sapiens_hsa051450.55832289
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54335520
118VEGF signaling pathway_Homo sapiens_hsa043700.53265254
119Platelet activation_Homo sapiens_hsa046110.53215827
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51499679
121Bile secretion_Homo sapiens_hsa049760.50834796
122Renin-angiotensin system_Homo sapiens_hsa046140.50307838
123Chemical carcinogenesis_Homo sapiens_hsa052040.50196710
124Starch and sucrose metabolism_Homo sapiens_hsa005000.50111109
125ABC transporters_Homo sapiens_hsa020100.50006886
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49587520
127Sphingolipid metabolism_Homo sapiens_hsa006000.49387703
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.48770582
129Vibrio cholerae infection_Homo sapiens_hsa051100.48070639
130T cell receptor signaling pathway_Homo sapiens_hsa046600.46995977
131Long-term potentiation_Homo sapiens_hsa047200.46791327
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.46305992
133Nucleotide excision repair_Homo sapiens_hsa034200.45718083
134Choline metabolism in cancer_Homo sapiens_hsa052310.45595278
135Renin secretion_Homo sapiens_hsa049240.45508840
136Viral carcinogenesis_Homo sapiens_hsa052030.44330119
137Acute myeloid leukemia_Homo sapiens_hsa052210.44174373
138Mismatch repair_Homo sapiens_hsa034300.43592362
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43437171
140Serotonergic synapse_Homo sapiens_hsa047260.43037139
141Endometrial cancer_Homo sapiens_hsa052130.41598226
142beta-Alanine metabolism_Homo sapiens_hsa004100.41182600
143Prostate cancer_Homo sapiens_hsa052150.40999374
144Asthma_Homo sapiens_hsa053100.40619959
145Sulfur metabolism_Homo sapiens_hsa009200.39833709
146Fanconi anemia pathway_Homo sapiens_hsa034600.39304589
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38931109
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38362733
149Cell cycle_Homo sapiens_hsa041100.38188354
150cAMP signaling pathway_Homo sapiens_hsa040240.37333588
151Calcium signaling pathway_Homo sapiens_hsa040200.36944077
152Arginine biosynthesis_Homo sapiens_hsa002200.36544338
153B cell receptor signaling pathway_Homo sapiens_hsa046620.36405230
154AMPK signaling pathway_Homo sapiens_hsa041520.35338843
155Metabolic pathways_Homo sapiens_hsa011000.35127727
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.34734118
157Synaptic vesicle cycle_Homo sapiens_hsa047210.30856458
158Nitrogen metabolism_Homo sapiens_hsa009100.29761669
159Shigellosis_Homo sapiens_hsa051310.29454790
160Pancreatic secretion_Homo sapiens_hsa049720.28401556
161Basal cell carcinoma_Homo sapiens_hsa052170.28077789
162Protein export_Homo sapiens_hsa030600.25522152
163Endocytosis_Homo sapiens_hsa041440.25425784
164Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23977427
165Salivary secretion_Homo sapiens_hsa049700.22590201

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