LFNG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pentose metabolic process (GO:0019321)6.34073532
2auditory receptor cell differentiation (GO:0042491)6.31018547
3regulation of gamma-delta T cell differentiation (GO:0045586)5.90207374
4negative regulation of cell killing (GO:0031342)5.67367016
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.67367016
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.60581980
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.60581980
8regulation of gamma-delta T cell activation (GO:0046643)5.39046242
9Notch signaling involved in heart development (GO:0061314)5.29378166
10positive regulation of gamma-delta T cell activation (GO:0046645)5.24786633
11detection of other organism (GO:0098543)5.21116468
12positive thymic T cell selection (GO:0045059)5.19867946
13negative T cell selection (GO:0043383)5.10042023
14detection of bacterium (GO:0016045)5.08971762
15negative thymic T cell selection (GO:0045060)5.06098945
16thymic T cell selection (GO:0045061)4.93410265
17antigen processing and presentation of endogenous antigen (GO:0019883)4.92981977
18neutrophil activation involved in immune response (GO:0002283)4.85618173
19pathway-restricted SMAD protein phosphorylation (GO:0060389)4.68835372
20endocardial cushion morphogenesis (GO:0003203)4.62873089
21macrophage activation involved in immune response (GO:0002281)4.55203950
22response to peptidoglycan (GO:0032494)4.39304628
23positive T cell selection (GO:0043368)4.36187385
24negative regulation of lymphocyte mediated immunity (GO:0002707)4.27192393
25T cell selection (GO:0045058)4.26262328
26detection of external biotic stimulus (GO:0098581)4.20796490
27negative regulation of interleukin-12 production (GO:0032695)4.17984426
28T cell migration (GO:0072678)4.15486091
29response to muramyl dipeptide (GO:0032495)4.06375351
30inner ear receptor cell differentiation (GO:0060113)4.02663091
31respiratory burst (GO:0045730)4.02218234
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01981009
33response to interleukin-15 (GO:0070672)3.86292609
34epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.85220971
35neutrophil activation (GO:0042119)3.84931741
36negative regulation of leukocyte mediated immunity (GO:0002704)3.84866190
37leukocyte aggregation (GO:0070486)3.84579841
38hair cell differentiation (GO:0035315)3.82076117
39detection of biotic stimulus (GO:0009595)3.77457168
40regulation of interferon-beta biosynthetic process (GO:0045357)3.73581304
41regulation of tolerance induction (GO:0002643)3.72145768
42detection of molecule of bacterial origin (GO:0032490)3.70247589
43negative regulation of T cell mediated immunity (GO:0002710)3.61241226
44immunoglobulin mediated immune response (GO:0016064)3.60226877
45leukocyte migration involved in inflammatory response (GO:0002523)3.59876640
46regulation of B cell receptor signaling pathway (GO:0050855)3.58770934
47regulation of mast cell degranulation (GO:0043304)3.58725465
48granulocyte activation (GO:0036230)3.56341488
49positive regulation of histone deacetylation (GO:0031065)3.54617052
50interferon-gamma production (GO:0032609)3.54263476
51mesenchyme morphogenesis (GO:0072132)3.51514805
52lens fiber cell development (GO:0070307)3.48372003
53response to host immune response (GO:0052572)3.47416688
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.47416688
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.47399217
56negative regulation of phagocytosis (GO:0050765)3.46974479
57activated T cell proliferation (GO:0050798)3.46166369
58cellular sodium ion homeostasis (GO:0006883)3.46152594
59type B pancreatic cell proliferation (GO:0044342)3.40281737
60regulation of myeloid leukocyte mediated immunity (GO:0002886)3.37767234
61regulation of leukocyte degranulation (GO:0043300)3.37324383
62regulation of extracellular matrix disassembly (GO:0010715)3.36459099
63myeloid cell activation involved in immune response (GO:0002275)3.34170609
64microglial cell activation (GO:0001774)3.32407423
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.32170046
66aorta morphogenesis (GO:0035909)3.30202004
67glycoprotein catabolic process (GO:0006516)3.29852255
68macrophage activation (GO:0042116)3.28614192
69response to host defenses (GO:0052200)3.27130757
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.27130757
71response to host (GO:0075136)3.27130757
72cellular response to interleukin-15 (GO:0071350)3.26356036
73regulation of mast cell activation involved in immune response (GO:0033006)3.25440331
74production of molecular mediator involved in inflammatory response (GO:0002532)3.18689454
75regulation of isotype switching to IgG isotypes (GO:0048302)3.18032853
76type I interferon signaling pathway (GO:0060337)3.17553878
77cellular response to type I interferon (GO:0071357)3.17553878
78response to type I interferon (GO:0034340)3.16808463
79mechanoreceptor differentiation (GO:0042490)3.16561859
80regulation of T cell tolerance induction (GO:0002664)3.15528390
81T cell receptor signaling pathway (GO:0050852)3.15347652
82regulation of interleukin-12 biosynthetic process (GO:0045075)3.14630441
83T cell costimulation (GO:0031295)3.09927678
84neutrophil mediated immunity (GO:0002446)3.07394388
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06629660
86regulation of T-helper 2 cell differentiation (GO:0045628)3.05688712
87regulation of T cell mediated cytotoxicity (GO:0001914)3.05678186
88regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03150846
89trabecula morphogenesis (GO:0061383)3.02870075
90lymphocyte costimulation (GO:0031294)3.01712341
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01055073
92protein polyglutamylation (GO:0018095)3.00892345
93regulation of mast cell activation (GO:0033003)2.98957555
94defense response to protozoan (GO:0042832)2.98171226
95negative regulation of innate immune response (GO:0045824)2.97624676
96regulation of natural killer cell mediated immunity (GO:0002715)2.96567393
97regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.96567393
98fat-soluble vitamin catabolic process (GO:0042363)2.96520545
99vitamin catabolic process (GO:0009111)2.96520545
100positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95506785
101interferon-gamma-mediated signaling pathway (GO:0060333)2.95010193
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94329784
103positive regulation of cellular amide metabolic process (GO:0034250)2.94086352
104natural killer cell differentiation (GO:0001779)2.93592044
105dendritic cell chemotaxis (GO:0002407)2.92837095
106positive regulation of B cell differentiation (GO:0045579)2.90290847
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89490869
108positive regulation of mast cell activation involved in immune response (GO:0033008)2.89028932
109positive regulation of mast cell degranulation (GO:0043306)2.89028932
110heterotypic cell-cell adhesion (GO:0034113)2.88926651
111heart valve formation (GO:0003188)2.87335567
112positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.85815960
113regulation of regulated secretory pathway (GO:1903305)2.84495011
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83885613
115regulation of B cell differentiation (GO:0045577)2.82454057
116negative regulation of alpha-beta T cell activation (GO:0046636)2.82006171
117germinal center formation (GO:0002467)2.81946807
118antigen receptor-mediated signaling pathway (GO:0050851)2.79623666
119positive regulation of mast cell activation (GO:0033005)2.77204917
120leukocyte cell-cell adhesion (GO:0007159)2.76592689
121neuronal stem cell maintenance (GO:0097150)2.74917513
122tolerance induction (GO:0002507)2.74823006
123modulation by symbiont of host defense response (GO:0052031)2.72470145
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.72470145
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.72470145
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.72470145
127modulation by symbiont of host immune response (GO:0052553)2.72470145
128positive regulation by symbiont of host defense response (GO:0052509)2.72470145
129response to laminar fluid shear stress (GO:0034616)2.72322020
130regulation of skeletal muscle cell differentiation (GO:2001014)2.71614103
131positive regulation of tolerance induction (GO:0002645)2.71241575
132heart trabecula morphogenesis (GO:0061384)2.70067970
133heart valve morphogenesis (GO:0003179)2.69700294
134growth hormone receptor signaling pathway (GO:0060396)2.69094116
135positive regulation of astrocyte differentiation (GO:0048711)2.68908561
136lipopolysaccharide biosynthetic process (GO:0009103)2.68763381
137positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.63644608
138regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61156281
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60175711
140lymphocyte migration (GO:0072676)2.60146269
141cellular extravasation (GO:0045123)2.59090398
142ventricular trabecula myocardium morphogenesis (GO:0003222)2.56713883
143cardiac ventricle morphogenesis (GO:0003208)2.56393006
144regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55953695
145ventricular septum morphogenesis (GO:0060412)2.55846619
146regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55727050
147neuroblast proliferation (GO:0007405)2.55423213
148epithelial cell fate commitment (GO:0072148)2.53496348
149antigen processing and presentation via MHC class Ib (GO:0002475)2.53443792
150natural killer cell activation (GO:0030101)2.53014200
151positive regulation of isotype switching (GO:0045830)2.49217152
152B cell receptor signaling pathway (GO:0050853)2.49164611
153T cell mediated immunity (GO:0002456)2.48897974
154positive regulation of protein deacetylation (GO:0090312)2.48720586
155negative regulation of erythrocyte differentiation (GO:0045647)2.48304763
156lung epithelium development (GO:0060428)2.46964028
157atrioventricular valve morphogenesis (GO:0003181)2.42879001
158somatic stem cell division (GO:0048103)2.42288115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.73630354
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70383845
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.60794592
4MYC_22102868_ChIP-Seq_BL_Human3.53289150
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.48993904
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.38775327
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.33869611
8VDR_21846776_ChIP-Seq_THP-1_Human2.89805917
9RUNX_20019798_ChIP-Seq_JUKART_Human2.85267940
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.71608895
11* KDM2B_26808549_Chip-Seq_DND41_Human2.67931979
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67913331
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.66273319
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.59420233
15* MAF_26560356_Chip-Seq_TH1_Human2.59416706
16* TCF7_22412390_ChIP-Seq_EML_Mouse2.55040451
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48747704
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44002294
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35446225
20UTX_26944678_Chip-Seq_JUKART_Human2.32224808
21* MYB_26560356_Chip-Seq_TH2_Human2.30103613
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.16128060
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10904920
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02496792
25MYB_26560356_Chip-Seq_TH1_Human2.02332673
26* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00282222
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99840472
28VDR_24763502_ChIP-Seq_THP-1_Human1.99354101
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97999858
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97356649
31* IRF8_27001747_Chip-Seq_BMDM_Mouse1.90101998
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89514338
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89476119
34* KDM2B_26808549_Chip-Seq_JURKAT_Human1.89178692
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84523444
36* LXR_22292898_ChIP-Seq_THP-1_Human1.80940511
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80897484
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80069063
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71048081
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69282771
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65246275
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65148406
43CLOCK_20551151_ChIP-Seq_293T_Human1.62862745
44* GATA3_27048872_Chip-Seq_THYMUS_Human1.62282122
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.61888291
46* MAF_26560356_Chip-Seq_TH2_Human1.59827254
47SPI1_23127762_ChIP-Seq_K562_Human1.59022934
48* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58108915
49* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56017989
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54927191
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49689482
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46659064
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43891358
54SCL_19346495_ChIP-Seq_HPC-7_Human1.38311881
55* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37132944
56* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37042969
57RACK7_27058665_Chip-Seq_MCF-7_Human1.36509283
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.35291045
59* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34896227
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32025046
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29314149
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28763868
63* FOXO3_23340844_ChIP-Seq_DLD1_Human1.28302032
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27488899
65* KDM2B_26808549_Chip-Seq_K562_Human1.26695237
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25777945
67* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25214411
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25121928
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24915194
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24715714
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23415540
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23106250
73VDR_24787735_ChIP-Seq_THP-1_Human1.21848725
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21514642
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21048215
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18628363
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17821200
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17601778
79* SPI1_23547873_ChIP-Seq_NB4_Human1.17056728
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16392332
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15109169
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14338720
83* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14248717
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14120531
85* BCOR_27268052_Chip-Seq_Bcells_Human1.13550000
86* BCL6_27268052_Chip-Seq_Bcells_Human1.13065242
87* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12745075
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.12452041
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11871563
90* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11773945
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11007507
92* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10148730
93* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07171566
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06558794
95NCOR1_26117541_ChIP-Seq_K562_Human1.05087996
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04198964
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03224752
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98707041
99* P68_20966046_ChIP-Seq_HELA_Human0.98673792
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98076695
101ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97800010
102PU_27001747_Chip-Seq_BMDM_Mouse0.96953121
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96640232
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94283528
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93552413
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93491395
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.93109078
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92967301
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91297935
110* SMC4_20622854_ChIP-Seq_HELA_Human0.91150410
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90813415
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.89282321
113GATA2_19941826_ChIP-Seq_K562_Human0.87119890
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86095066
115GATA1_19941826_ChIP-Seq_K562_Human0.85847698
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85514587
117* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85340732
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85225179
119IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85013566
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.84489945
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83136018
122BP1_19119308_ChIP-ChIP_Hs578T_Human0.82695159
123* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82491251
124CREB1_26743006_Chip-Seq_LNCaP_Human0.82395544
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81449438
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80895449
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80318397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.34570495
2MP0003878_abnormal_ear_physiology5.34570495
3MP0003879_abnormal_hair_cell3.47408378
4MP0001485_abnormal_pinna_reflex3.30925757
5MP0003763_abnormal_thymus_physiology2.74242647
6MP0003300_gastrointestinal_ulcer2.72417754
7MP0003303_peritoneal_inflammation2.62191496
8MP0000685_abnormal_immune_system2.62130740
9MP0005671_abnormal_response_to2.50810284
10MP0001800_abnormal_humoral_immune2.25957415
11MP0008260_abnormal_autophagy2.23270199
12MP0001835_abnormal_antigen_presentation2.18630192
13MP0002166_altered_tumor_susceptibility2.10967276
14MP0003436_decreased_susceptibility_to2.06419158
15MP0003705_abnormal_hypodermis_morpholog2.06251832
16MP0005387_immune_system_phenotype2.06233586
17MP0001790_abnormal_immune_system2.06233586
18MP0009278_abnormal_bone_marrow2.00622542
19MP0002420_abnormal_adaptive_immunity2.00155086
20MP0001819_abnormal_immune_cell1.98007912
21MP0002452_abnormal_antigen_presenting1.92485241
22MP0004510_myositis1.90133130
23MP0002398_abnormal_bone_marrow1.84987075
24MP0001963_abnormal_hearing_physiology1.84554836
25MP0005000_abnormal_immune_tolerance1.83912852
26MP0002723_abnormal_immune_serum1.82213898
27MP0002653_abnormal_ependyma_morphology1.81009134
28MP0006082_CNS_inflammation1.77761263
29MP0000026_abnormal_inner_ear1.69029747
30MP0000703_abnormal_thymus_morphology1.68710577
31MP0002089_abnormal_postnatal_growth/wei1.68106463
32MP0002405_respiratory_system_inflammati1.64681971
33MP0002132_abnormal_respiratory_system1.64128710
34MP0000716_abnormal_immune_system1.62079385
35MP0002006_tumorigenesis1.60836815
36MP0003183_abnormal_peptide_metabolism1.60302880
37MP0005025_abnormal_response_to1.59745401
38MP0003448_altered_tumor_morphology1.57472364
39MP0004808_abnormal_hematopoietic_stem1.57182287
40MP0002419_abnormal_innate_immunity1.56236007
41MP0005076_abnormal_cell_differentiation1.53862766
42MP0009780_abnormal_chondrocyte_physiolo1.53404928
43MP0001873_stomach_inflammation1.50909132
44MP0002722_abnormal_immune_system1.50558022
45MP0002277_abnormal_respiratory_mucosa1.47500875
46MP0004947_skin_inflammation1.44624075
47MP0002009_preneoplasia1.42319622
48MP0000689_abnormal_spleen_morphology1.38927231
49MP0010155_abnormal_intestine_physiology1.36886124
50MP0002396_abnormal_hematopoietic_system1.36274846
51MP0005464_abnormal_platelet_physiology1.35417675
52MP0005451_abnormal_body_composition1.33785519
53MP0008469_abnormal_protein_level1.32374021
54MP0009333_abnormal_splenocyte_physiolog1.31480276
55MP0010234_abnormal_vibrissa_follicle1.30310396
56* MP0002429_abnormal_blood_cell1.28118211
57MP0003566_abnormal_cell_adhesion1.27886604
58MP0004883_abnormal_blood_vessel1.27818464
59MP0010352_gastrointestinal_tract_polyps1.27115470
60MP0001533_abnormal_skeleton_physiology1.26869677
61MP0009785_altered_susceptibility_to1.25352644
62MP0002933_joint_inflammation1.22926250
63MP0003453_abnormal_keratinocyte_physiol1.21121881
64MP0009764_decreased_sensitivity_to1.15499311
65MP0008961_abnormal_basal_metabolism1.13882613
66MP0003866_abnormal_defecation1.12988361
67MP0005058_abnormal_lysosome_morphology1.12986297
68MP0000383_abnormal_hair_follicle1.12355632
69MP0001851_eye_inflammation1.09190677
70MP0000566_synostosis1.08896342
71MP0001663_abnormal_digestive_system1.08299959
72MP0004858_abnormal_nervous_system1.07479131
73MP0002148_abnormal_hypersensitivity_rea1.04808280
74MP0004381_abnormal_hair_follicle1.04271433
75MP0005397_hematopoietic_system_phenotyp1.03184616
76MP0001545_abnormal_hematopoietic_system1.03184616
77MP0001845_abnormal_inflammatory_respons1.02863714
78MP0000858_altered_metastatic_potential1.01702779
79MP0001958_emphysema1.00010597
80MP0010678_abnormal_skin_adnexa0.98977163
81MP0000465_gastrointestinal_hemorrhage0.95968884
82MP0005166_decreased_susceptibility_to0.95557395
83MP0001849_ear_inflammation0.94189779
84MP0000428_abnormal_craniofacial_morphol0.92785586
85MP0001915_intracranial_hemorrhage0.91912031
86MP0004134_abnormal_chest_morphology0.91735392
87MP0000767_abnormal_smooth_muscle0.91254362
88MP0001853_heart_inflammation0.89655173
89MP0000343_altered_response_to0.88216343
90MP0005164_abnormal_response_to0.86512904
91MP0002998_abnormal_bone_remodeling0.84055905
92MP0005023_abnormal_wound_healing0.83397916
93MP0005248_abnormal_Harderian_gland0.83065612
94MP0009840_abnormal_foam_cell0.82349632
95MP0003091_abnormal_cell_migration0.80693169
96MP0000733_abnormal_muscle_development0.80253435
97MP0003172_abnormal_lysosome_physiology0.80168970
98MP0004185_abnormal_adipocyte_glucose0.77174602
99MP0000604_amyloidosis0.76486755
100MP0004130_abnormal_muscle_cell0.74577879
101MP0004885_abnormal_endolymph0.72941472
102MP0005381_digestive/alimentary_phenotyp0.72173614
103MP0005310_abnormal_salivary_gland0.71301179
104* MP0005390_skeleton_phenotype0.68535355
105MP0010307_abnormal_tumor_latency0.68452016
106MP0003191_abnormal_cellular_cholesterol0.68118791
107MP0000249_abnormal_blood_vessel0.67671945
108MP0003724_increased_susceptibility_to0.67545424
109MP0002928_abnormal_bile_duct0.67355650
110MP0008004_abnormal_stomach_pH0.67116818
111MP0003075_altered_response_to0.66930913
112MP0000490_abnormal_crypts_of0.65787923
113MP0009763_increased_sensitivity_to0.65623774
114MP0000049_abnormal_middle_ear0.65466905
115MP0003828_pulmonary_edema0.65233704
116MP0003795_abnormal_bone_structure0.65169879
117MP0005075_abnormal_melanosome_morpholog0.64863970
118MP0003690_abnormal_glial_cell0.64546921
119MP0005623_abnormal_meninges_morphology0.64273225
120MP0003045_fibrosis0.62958050
121MP0002133_abnormal_respiratory_system0.61941423
122MP0005388_respiratory_system_phenotype0.61941423
123MP0003329_amyloid_beta_deposits0.59805305
124MP0002138_abnormal_hepatobiliary_system0.58928226
125MP0002254_reproductive_system_inflammat0.56328095
126MP0008874_decreased_physiological_sensi0.53621647

Predicted human phenotypes

RankGene SetZ-score
1Mixed hearing impairment (HP:0000410)6.13327323
2Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.56069832
3Orchitis (HP:0100796)5.13630944
4Epiphyseal dysplasia (HP:0002656)5.09458950
5Recurrent gram-negative bacterial infections (HP:0005420)4.78724955
6Retrobulbar optic neuritis (HP:0100654)4.73476949
7Optic neuritis (HP:0100653)4.73476949
8Unilateral renal agenesis (HP:0000122)4.66468815
9Hypoplastic ischia (HP:0003175)4.40508365
10Bilateral microphthalmos (HP:0007633)4.38022031
11Mediastinal lymphadenopathy (HP:0100721)4.09145064
12Chronic obstructive pulmonary disease (HP:0006510)3.98032575
13Obstructive lung disease (HP:0006536)3.98032575
14Gastrointestinal infarctions (HP:0005244)3.90985553
15Meningitis (HP:0001287)3.88078893
16Abnormality of the ischium (HP:0003174)3.73336884
17Increased IgE level (HP:0003212)3.62284637
18Gingivitis (HP:0000230)3.57478468
19Encephalitis (HP:0002383)3.41471779
20Synostosis involving the elbow (HP:0003938)3.41066587
21Humeroradial synostosis (HP:0003041)3.41066587
22Cellulitis (HP:0100658)3.39344387
23Abnormality of the pubic bones (HP:0003172)3.39085320
24Vasculitis (HP:0002633)3.20852439
25Urticaria (HP:0001025)3.19171835
26Recurrent cutaneous fungal infections (HP:0011370)3.10465091
27Chronic mucocutaneous candidiasis (HP:0002728)3.10465091
28Nasal polyposis (HP:0100582)3.10256546
29Aplasia/Hypoplasia of the fovea (HP:0008060)3.05513869
30Hypoplasia of the fovea (HP:0007750)3.05513869
31Vertebral clefting (HP:0008428)3.02711797
32T lymphocytopenia (HP:0005403)3.00981927
33Arterial tortuosity (HP:0005116)3.00313173
34Fused cervical vertebrae (HP:0002949)2.97859043
35Prolonged bleeding time (HP:0003010)2.97697358
36Oligodactyly (HP:0012165)2.95522960
37Chest pain (HP:0100749)2.94175714
38Chronic otitis media (HP:0000389)2.88795217
39Vertebral arch anomaly (HP:0008438)2.84312586
40Abnormality of T cell number (HP:0011839)2.83432572
41Hypochromic microcytic anemia (HP:0004840)2.80556291
42Recurrent bacterial skin infections (HP:0005406)2.80512011
43Bicuspid aortic valve (HP:0001647)2.79493904
44Hypochromic anemia (HP:0001931)2.79077400
45Amyloidosis (HP:0011034)2.79027587
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.77971216
47Absent epiphyses (HP:0010577)2.77971216
48Pulmonary infiltrates (HP:0002113)2.77909179
49Hemoptysis (HP:0002105)2.77732321
50Abnormality of the nasal mucosa (HP:0000433)2.77367886
51Multifactorial inheritance (HP:0001426)2.62552001
52Enlarged epiphyses (HP:0010580)2.58416033
53Episodic fever (HP:0001954)2.56387078
54Vascular tortuosity (HP:0004948)2.56110766
55Elevated erythrocyte sedimentation rate (HP:0003565)2.53323032
56Leukocytosis (HP:0001974)2.48314519
57Abnormality of the fingertips (HP:0001211)2.43881272
58Lymphopenia (HP:0001888)2.43621264
59Exostoses (HP:0100777)2.41780081
60Abnormality of the fovea (HP:0000493)2.40819151
61Arterial thrombosis (HP:0004420)2.40369961
62Pulmonary embolism (HP:0002204)2.40361883
63Partial duplication of thumb phalanx (HP:0009944)2.39442562
64Osteomyelitis (HP:0002754)2.39422700
65Eczematoid dermatitis (HP:0000976)2.38821641
66Bell-shaped thorax (HP:0001591)2.37807781
67Spontaneous hematomas (HP:0007420)2.35966562
68Sepsis (HP:0100806)2.35234184
69Epistaxis (HP:0000421)2.34661982
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.34220069
71Anorexia (HP:0002039)2.32503540
72Flared metaphyses (HP:0003015)2.31590724
73Recurrent viral infections (HP:0004429)2.30248487
74IgM deficiency (HP:0002850)2.28826920
75Inflammation of the large intestine (HP:0002037)2.27327893
76Gastrointestinal inflammation (HP:0004386)2.27242177
77Protuberant abdomen (HP:0001538)2.26303842
78Recurrent abscess formation (HP:0002722)2.26068712
79Cerebral aneurysm (HP:0004944)2.25970187
80Increased IgM level (HP:0003496)2.25659832
81Peritonitis (HP:0002586)2.25338893
82Plagiocephaly (HP:0001357)2.24962458
83Gingival bleeding (HP:0000225)2.24958932
84Premature loss of primary teeth (HP:0006323)2.24536458
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.23482646
86Recurrent fungal infections (HP:0002841)2.21687214
87Glossoptosis (HP:0000162)2.21337819
88Abnormality of liposaccharide metabolism (HP:0010968)2.20861485
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.20861485
90Abnormality of glycolipid metabolism (HP:0010969)2.20861485
91Loss of speech (HP:0002371)2.20369070
92Pustule (HP:0200039)2.19631604
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17693756
94Recurrent bronchitis (HP:0002837)2.15767312
95Myositis (HP:0100614)2.15294632
96Sprengel anomaly (HP:0000912)2.14660138
97Petechiae (HP:0000967)2.14092617
98Skin ulcer (HP:0200042)2.12445609
99Colitis (HP:0002583)2.11822589
100Increased density of long bones (HP:0006392)2.11414846
101Adactyly (HP:0009776)2.10265482
102Aplasia/Hypoplasia of the macula (HP:0008059)2.09930303
103Segmental peripheral demyelination/remyelination (HP:0003481)2.09929894
104Spondylolisthesis (HP:0003302)2.09623005
105Abnormal delayed hypersensitivity skin test (HP:0002963)2.09273426
106Purpura (HP:0000979)2.08766812
107Slow saccadic eye movements (HP:0000514)2.06983640
108Partial duplication of the phalanx of hand (HP:0009999)2.06906102
109Metaphyseal cupping (HP:0003021)2.05909436
110Abnormality of the lumbar spine (HP:0100712)2.04932691
111Disproportionate tall stature (HP:0001519)2.04627046
112Abnormality of the pleura (HP:0002103)2.04338976
113Malnutrition (HP:0004395)2.04086302
114Granulocytopenia (HP:0001913)2.03625492
115Agammaglobulinemia (HP:0004432)2.03299812
116Gangrene (HP:0100758)2.02275940
117Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.02272762
118Recurrent corneal erosions (HP:0000495)2.02042590
119Abnormality of T cells (HP:0002843)2.00786817
120Hyperacusis (HP:0010780)2.00750876
121Aplasia/Hypoplasia affecting the retina (HP:0008061)1.99619539
122Microcytic anemia (HP:0001935)1.99576855
123Restrictive lung disease (HP:0002091)1.98783606
124Hypergammaglobulinemia (HP:0010702)1.98240756
125Aplasia involving bones of the upper limbs (HP:0009823)1.97608486
126Aplasia of the phalanges of the hand (HP:0009802)1.97608486
127Aplasia involving bones of the extremities (HP:0009825)1.97608486
128Hematochezia (HP:0002573)1.97368414
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97215586
130Increased serum ferritin (HP:0003281)1.95941486
131Mitral valve prolapse (HP:0001634)1.94557065
132Glomerulopathy (HP:0100820)1.94376349
133Acne (HP:0001061)1.93547234
134Keratoconjunctivitis sicca (HP:0001097)1.92169645
135Hepatosplenomegaly (HP:0001433)1.92059511
136Skin tags (HP:0010609)1.90710436
137Dysostosis multiplex (HP:0000943)1.90169381
138Recurrent skin infections (HP:0001581)1.89460013
139Viral hepatitis (HP:0006562)1.88797185
140Aortic dissection (HP:0002647)1.88651854
141Verrucae (HP:0200043)1.88067607
142Papilloma (HP:0012740)1.88067607
143Lumbar hyperlordosis (HP:0002938)1.87532960
144Gastrointestinal stroma tumor (HP:0100723)1.87394148
145Abnormality of the endocardium (HP:0004306)1.86678888
146Abnormality of the peritoneum (HP:0002585)1.86570490
147Megalencephaly (HP:0001355)1.82672943
148Autoimmune thrombocytopenia (HP:0001973)1.82276220
149Abnormality of the humeroradial joint (HP:0100744)1.81908067
150Subacute progressive viral hepatitis (HP:0006572)1.81084579
151Abnormal platelet volume (HP:0011876)1.80008518
152Polygenic inheritance (HP:0010982)1.79290303
153Rhizomelia (HP:0008905)1.79232013
154Preauricular skin tag (HP:0000384)1.77972933
155Recurrent pneumonia (HP:0006532)1.77726693
156Aortic aneurysm (HP:0004942)1.77255510
157Abnormality of the pericardium (HP:0001697)1.76782999
158Panhypogammaglobulinemia (HP:0003139)1.76299271
159Synostosis of carpal bones (HP:0005048)1.76255396
160Skull defect (HP:0001362)1.73762098
161Increased cerebral lipofuscin (HP:0011813)1.73066373
162Osteoarthritis (HP:0002758)1.71712771
163Broad ribs (HP:0000885)1.71064978
164Heterotopia (HP:0002282)1.70788020
165Abnormality of macrophages (HP:0004311)1.69388053
166Alopecia of scalp (HP:0002293)1.69301867
167Stomatitis (HP:0010280)1.68572768
168Vertebral fusion (HP:0002948)1.67726618
169Dilatation of the ascending aorta (HP:0005111)1.64172249
170Keratoconjunctivitis (HP:0001096)1.63670882
171Radial bowing (HP:0002986)1.62848918
172Lip pit (HP:0100267)1.62075317
173Hypoplastic ilia (HP:0000946)1.61627424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.69636159
2MAP4K13.80425992
3TRIB33.37455912
4PRPF4B2.84712435
5MAP3K102.80211901
6FGFR32.55022838
7EEF2K2.54983503
8PKN22.53634305
9STK102.24500698
10GRK62.14661895
11TXK2.10267967
12JAK32.01447396
13EPHB11.96821255
14ITK1.93192483
15TYK21.92340131
16SIK11.83115024
17FGFR41.77861650
18MAP3K31.74098721
19MARK31.73872685
20LRRK21.62198239
21TGFBR21.61924425
22ERN11.59227923
23ZAP701.59040739
24MAP3K111.58569794
25TESK21.58162376
26JAK11.54902891
27SMG11.43410746
28MAP3K131.40924776
29SIK31.38626156
30PTK61.36401514
31RIPK11.35829189
32TRPM71.31781370
33SIK21.31270495
34MAP3K11.22361117
35CSK1.22190168
36HCK1.18730934
37BTK1.17708797
38PRKCH1.16599070
39TBK11.16459182
40DYRK1B1.15152261
41CDK61.14647349
42TTN1.09282090
43JAK21.03947057
44IKBKE1.02298294
45LCK0.99176285
46CDK120.94640750
47BLK0.94294160
48FES0.93679016
49TAOK10.93352456
50MATK0.92331528
51CSF1R0.92236260
52PAK40.91092660
53FGFR10.88608514
54DMPK0.87886761
55MAP3K140.87469415
56CDC42BPA0.86121355
57TYRO30.84646202
58MAP3K70.84418956
59KIT0.83398276
60CLK10.82305362
61PIM10.80506347
62HIPK20.79960754
63BMX0.79188067
64TAOK20.78350988
65IRAK20.77329953
66ALK0.74531586
67PDPK10.73105067
68CAMK1G0.71639814
69IRAK30.67218741
70CDK190.66794137
71IRAK10.66752915
72SYK0.66332697
73SCYL20.65952844
74TAOK30.64606282
75RIPK40.64147818
76MAP3K20.63459018
77CAMKK10.63449945
78PDGFRB0.62951667
79MAPK120.62876650
80PRKCQ0.61261661
81MAP3K60.60925869
82RET0.60597236
83MAPK70.58981185
84TEC0.58550096
85KDR0.57679927
86BRD40.57221711
87STK110.54749566
88RPS6KC10.54382664
89RPS6KL10.54382664
90RPS6KA60.54099515
91IRAK40.52577039
92FGR0.52351859
93NLK0.50442122
94CAMK1D0.50350692
95UHMK10.50086788
96IKBKB0.49614247
97TNK20.47617548
98NEK20.47081389
99SGK30.46519031
100PDGFRA0.46319011
101PRKD20.45813477
102LYN0.45362209
103MAP2K30.44881631
104CDK40.44386040
105MAP3K80.43497288
106RPS6KA20.43305077
107PDK10.42915109
108MAP2K20.41778854
109RPS6KA40.41654818
110CHUK0.40632028
111ILK0.40603127
112KSR10.40504657
113ICK0.39852663
114KSR20.39448408
115FGFR20.38357749
116PRKG20.37271459
117MAPKAPK20.36674353
118PTK20.36035271
119MARK20.35948247
120STK40.34504592
121EGFR0.34071899
122YES10.33586323
123RPS6KA10.32858918
124STK380.32204079
125FYN0.31448898
126BMPR20.31168433
127LMTK20.31143364
128ROCK20.28659792
129PASK0.28609005
130IGF1R0.28308029

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.49200276
2T cell receptor signaling pathway_Homo sapiens_hsa046602.34128034
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.28005970
4Autoimmune thyroid disease_Homo sapiens_hsa053202.12691110
5Leishmaniasis_Homo sapiens_hsa051402.04924757
6Osteoclast differentiation_Homo sapiens_hsa043802.03617951
7B cell receptor signaling pathway_Homo sapiens_hsa046621.97909145
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97449741
9Chronic myeloid leukemia_Homo sapiens_hsa052201.96373859
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87398736
11Dorso-ventral axis formation_Homo sapiens_hsa043201.86484925
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83779302
13Viral myocarditis_Homo sapiens_hsa054161.75382535
14Antigen processing and presentation_Homo sapiens_hsa046121.74525761
15Graft-versus-host disease_Homo sapiens_hsa053321.73742276
16Measles_Homo sapiens_hsa051621.68669598
17* Notch signaling pathway_Homo sapiens_hsa043301.68556187
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.68151620
19Other glycan degradation_Homo sapiens_hsa005111.64858855
20Type I diabetes mellitus_Homo sapiens_hsa049401.63606741
21Toxoplasmosis_Homo sapiens_hsa051451.57432686
22Pancreatic cancer_Homo sapiens_hsa052121.57119562
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53733824
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.43423128
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41006069
26Colorectal cancer_Homo sapiens_hsa052101.40132826
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38321125
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34011761
29Hepatitis B_Homo sapiens_hsa051611.30604670
30Chemokine signaling pathway_Homo sapiens_hsa040621.30012406
31Acute myeloid leukemia_Homo sapiens_hsa052211.29792405
32Phagosome_Homo sapiens_hsa041451.26966812
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.26153507
34TNF signaling pathway_Homo sapiens_hsa046681.25532645
35Staphylococcus aureus infection_Homo sapiens_hsa051501.25527181
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.24503736
37Basal cell carcinoma_Homo sapiens_hsa052171.23856186
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23406556
39Proteoglycans in cancer_Homo sapiens_hsa052051.21029238
40HTLV-I infection_Homo sapiens_hsa051661.18731765
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17898231
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.16501641
43VEGF signaling pathway_Homo sapiens_hsa043701.15176994
44Hippo signaling pathway_Homo sapiens_hsa043901.12400439
45Shigellosis_Homo sapiens_hsa051311.11435453
46Legionellosis_Homo sapiens_hsa051341.11122457
47Apoptosis_Homo sapiens_hsa042101.10606705
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07876401
49Small cell lung cancer_Homo sapiens_hsa052221.07697048
50Non-small cell lung cancer_Homo sapiens_hsa052231.07647201
51Platelet activation_Homo sapiens_hsa046111.04144433
52Prolactin signaling pathway_Homo sapiens_hsa049171.03587027
53Asthma_Homo sapiens_hsa053101.02601194
54Allograft rejection_Homo sapiens_hsa053301.00002619
55Tuberculosis_Homo sapiens_hsa051520.98396046
56Renal cell carcinoma_Homo sapiens_hsa052110.97634130
57Malaria_Homo sapiens_hsa051440.95960120
58Endometrial cancer_Homo sapiens_hsa052130.95762827
59African trypanosomiasis_Homo sapiens_hsa051430.95602527
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95017178
61Hematopoietic cell lineage_Homo sapiens_hsa046400.94977387
62Focal adhesion_Homo sapiens_hsa045100.93736842
63Herpes simplex infection_Homo sapiens_hsa051680.93228202
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92326546
65MicroRNAs in cancer_Homo sapiens_hsa052060.92246711
66Insulin resistance_Homo sapiens_hsa049310.91510169
67* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90989089
68Lysine degradation_Homo sapiens_hsa003100.89939415
69Influenza A_Homo sapiens_hsa051640.88820531
70Fatty acid biosynthesis_Homo sapiens_hsa000610.88636635
71Rheumatoid arthritis_Homo sapiens_hsa053230.88612776
72TGF-beta signaling pathway_Homo sapiens_hsa043500.87819829
73Adherens junction_Homo sapiens_hsa045200.87709739
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86983854
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84881126
76Hepatitis C_Homo sapiens_hsa051600.84735496
77Glioma_Homo sapiens_hsa052140.82479939
78Bladder cancer_Homo sapiens_hsa052190.82382390
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81182744
80mTOR signaling pathway_Homo sapiens_hsa041500.80540545
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80332734
82Pertussis_Homo sapiens_hsa051330.78783013
83Endocytosis_Homo sapiens_hsa041440.78415571
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78277868
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76803603
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75155286
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.74235525
88Viral carcinogenesis_Homo sapiens_hsa052030.73838644
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73803706
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73305930
91Rap1 signaling pathway_Homo sapiens_hsa040150.72301262
92Pathways in cancer_Homo sapiens_hsa052000.71841474
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71553304
94GnRH signaling pathway_Homo sapiens_hsa049120.69059192
95FoxO signaling pathway_Homo sapiens_hsa040680.67998443
96Epstein-Barr virus infection_Homo sapiens_hsa051690.67935486
97Salmonella infection_Homo sapiens_hsa051320.67164573
98Inositol phosphate metabolism_Homo sapiens_hsa005620.65899997
99Prostate cancer_Homo sapiens_hsa052150.63064718
100ErbB signaling pathway_Homo sapiens_hsa040120.63003363
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62875586
102Amoebiasis_Homo sapiens_hsa051460.61545307
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.61180296
104Protein digestion and absorption_Homo sapiens_hsa049740.61131377
105HIF-1 signaling pathway_Homo sapiens_hsa040660.60268894
106Estrogen signaling pathway_Homo sapiens_hsa049150.60256474
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58906806
108Thyroid cancer_Homo sapiens_hsa052160.58104058
109ECM-receptor interaction_Homo sapiens_hsa045120.57584685
110MAPK signaling pathway_Homo sapiens_hsa040100.57578615
111Lysosome_Homo sapiens_hsa041420.56238209
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.56192063
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.55460419
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.55094069
115Melanogenesis_Homo sapiens_hsa049160.54847684
116Wnt signaling pathway_Homo sapiens_hsa043100.51001004
117Choline metabolism in cancer_Homo sapiens_hsa052310.50921946
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.47069999
119Insulin signaling pathway_Homo sapiens_hsa049100.45204548
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44274586
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43437425

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