LGALS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.35339386
2collagen fibril organization (GO:0030199)4.78682519
3protein heterotrimerization (GO:0070208)4.76298817
4regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.35852072
5skin morphogenesis (GO:0043589)4.20537998
6protein localization to endosome (GO:0036010)4.17581998
7cell migration involved in heart development (GO:0060973)4.12750221
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.11704870
9cell adhesion mediated by integrin (GO:0033627)4.08456717
10wound healing, spreading of epidermal cells (GO:0035313)4.08430657
11adhesion of symbiont to host cell (GO:0044650)4.07694010
12virion attachment to host cell (GO:0019062)4.07694010
13type B pancreatic cell proliferation (GO:0044342)4.03031633
14endodermal cell differentiation (GO:0035987)4.02356890
15regulation of protein heterodimerization activity (GO:0043497)4.00857996
16cellular response to interferon-alpha (GO:0035457)3.88452512
17mesenchymal-epithelial cell signaling (GO:0060638)3.84940379
18positive regulation of endothelial cell apoptotic process (GO:2000353)3.82944902
19negative regulation of nitric-oxide synthase activity (GO:0051001)3.82466852
20pinocytosis (GO:0006907)3.77245713
21sequestering of extracellular ligand from receptor (GO:0035581)3.76491925
22protein maturation by protein folding (GO:0022417)3.65339874
23negative regulation of nitric oxide biosynthetic process (GO:0045019)3.63798842
24adhesion of symbiont to host (GO:0044406)3.63590656
25membrane raft organization (GO:0031579)3.60927985
26apoptotic cell clearance (GO:0043277)3.59125628
27negative regulation of fatty acid transport (GO:2000192)3.55348892
28regulation of metalloenzyme activity (GO:0048552)3.52560897
29regulation of integrin-mediated signaling pathway (GO:2001044)3.50681887
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49444375
31regulation of tight junction assembly (GO:2000810)3.48993433
32wound healing, spreading of cells (GO:0044319)3.47289765
33hyaluronan catabolic process (GO:0030214)3.45324659
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.41996899
35positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.28901688
36protein retention in ER lumen (GO:0006621)3.27617040
37peptidyl-proline hydroxylation (GO:0019511)3.26670574
38collagen metabolic process (GO:0032963)3.24081853
39Golgi transport vesicle coating (GO:0048200)3.22879937
40COPI coating of Golgi vesicle (GO:0048205)3.22879937
41platelet aggregation (GO:0070527)3.22097061
42stress fiber assembly (GO:0043149)3.21183675
43plasma membrane repair (GO:0001778)3.20737053
44barbed-end actin filament capping (GO:0051016)3.19376738
45hypotonic response (GO:0006971)3.17553305
46dermatan sulfate biosynthetic process (GO:0030208)3.16737765
47hemidesmosome assembly (GO:0031581)3.16545765
48glial cell migration (GO:0008347)3.10420638
49collagen catabolic process (GO:0030574)3.10018410
50basement membrane organization (GO:0071711)3.09263014
51low-density lipoprotein particle clearance (GO:0034383)3.08682610
52viral transcription (GO:0019083)3.07374838
53regulation of extracellular matrix disassembly (GO:0010715)3.06979440
54cortical actin cytoskeleton organization (GO:0030866)3.06570486
55fibril organization (GO:0097435)3.06527176
56myeloid cell homeostasis (GO:0002262)3.04854648
57keratan sulfate catabolic process (GO:0042340)3.02149511
58cellular response to zinc ion (GO:0071294)3.01820910
59translational termination (GO:0006415)3.01619393
60cell-substrate junction assembly (GO:0007044)3.01301491
61axon extension involved in axon guidance (GO:0048846)3.01152007
62neuron projection extension involved in neuron projection guidance (GO:1902284)3.01152007
63positive regulation of extracellular matrix organization (GO:1903055)3.00387095
64extracellular matrix assembly (GO:0085029)2.98283817
65multicellular organismal macromolecule metabolic process (GO:0044259)2.97038795
66endothelial cell morphogenesis (GO:0001886)2.96131145
67T cell apoptotic process (GO:0070231)2.95949851
68histone-serine phosphorylation (GO:0035404)2.95699799
69protein hydroxylation (GO:0018126)2.89177627
70sequestering of actin monomers (GO:0042989)2.86244569
71heterochromatin organization (GO:0070828)2.86106336
72dermatan sulfate metabolic process (GO:0030205)2.84964494
73extracellular matrix disassembly (GO:0022617)2.84164799
74regulation of mononuclear cell migration (GO:0071675)2.83875242
75substrate adhesion-dependent cell spreading (GO:0034446)2.83420449
76regulation of cell aging (GO:0090342)2.82752109
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80789678
78positive regulation of blood vessel endothelial cell migration (GO:0043536)2.80505361
79negative regulation of phagocytosis (GO:0050765)2.79273587
80UV protection (GO:0009650)2.79038680
81multicellular organismal metabolic process (GO:0044236)2.78428779
82multicellular organismal catabolic process (GO:0044243)2.77993853
83negative regulation of smooth muscle cell migration (GO:0014912)2.77075551
84vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76663222
85positive regulation of epithelial to mesenchymal transition (GO:0010718)2.74132968
86negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.74042311
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73012326
88negative regulation of cell size (GO:0045792)2.72200344
89translational elongation (GO:0006414)2.71915011
90positive regulation of natural killer cell differentiation (GO:0032825)2.71619257
91positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.70134070
92regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.69733710
93formation of translation preinitiation complex (GO:0001731)2.69290480
94substrate-dependent cell migration (GO:0006929)2.68334761
95dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68312539
96protein targeting to ER (GO:0045047)2.68113500
97protein targeting to plasma membrane (GO:0072661)2.66907147
98extracellular fibril organization (GO:0043206)2.66130244
99negative regulation of monooxygenase activity (GO:0032769)2.65104042
100regulation of smooth muscle cell migration (GO:0014910)2.64918659
101muscle cell migration (GO:0014812)2.63179134
102regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.62354801
103vascular endothelial growth factor signaling pathway (GO:0038084)2.62315756
104cotranslational protein targeting to membrane (GO:0006613)2.61995614
105cortical cytoskeleton organization (GO:0030865)2.61445275
106cellular response to vitamin (GO:0071295)2.61212904
107regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60806773
108retina vasculature morphogenesis in camera-type eye (GO:0061299)2.59893463
109metanephric mesenchyme development (GO:0072075)2.59743354
110bone trabecula formation (GO:0060346)2.59316202
111response to magnesium ion (GO:0032026)2.58382943
112regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58293251
113actin filament depolymerization (GO:0030042)2.57928197
114heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.56061220
115establishment of protein localization to endoplasmic reticulum (GO:0072599)2.56025559
116regulation of collagen metabolic process (GO:0010712)2.55779314
117translational initiation (GO:0006413)2.55778830
118lymphocyte apoptotic process (GO:0070227)2.55098870
119regulation of early endosome to late endosome transport (GO:2000641)2.54590620
120negative regulation of chondrocyte differentiation (GO:0032331)2.54216350
121cellular response to vitamin D (GO:0071305)2.52956721
122decidualization (GO:0046697)2.52407863
123regulation of monocyte chemotaxis (GO:0090025)2.52056592
124regulation of membrane protein ectodomain proteolysis (GO:0051043)2.50134056
125positive regulation of actin filament depolymerization (GO:0030836)2.49893907
126protein localization to cell surface (GO:0034394)2.49419531
127embryo implantation (GO:0007566)2.49190766
128venous blood vessel morphogenesis (GO:0048845)2.48698970
129response to progesterone (GO:0032570)2.48617718
130vagina development (GO:0060068)2.48415504
131regulation of histone phosphorylation (GO:0033127)2.48329037
132protein localization to endoplasmic reticulum (GO:0070972)2.48251134
133extracellular matrix organization (GO:0030198)2.48212079
134positive regulation of receptor recycling (GO:0001921)2.47888758
135membrane budding (GO:0006900)2.47514809
136extracellular structure organization (GO:0043062)2.47224797
137actin nucleation (GO:0045010)2.46970100
138outer ear morphogenesis (GO:0042473)2.45532313
139endocardial cushion development (GO:0003197)2.44987034
140positive regulation of macrophage activation (GO:0043032)2.44892164
141cellular protein complex disassembly (GO:0043624)2.44342452
142viral life cycle (GO:0019058)2.44090816
143positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.43817414
144positive regulation of axon extension (GO:0045773)2.43664662
145kidney mesenchyme development (GO:0072074)2.43250177
146platelet degranulation (GO:0002576)2.42612462
147nucleobase-containing small molecule interconversion (GO:0015949)2.42403047
148endocytic recycling (GO:0032456)2.41694160
149regulation of plasminogen activation (GO:0010755)2.40920472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse4.44477409
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.30244505
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.15629878
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30699513
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.99216672
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96410588
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.75995709
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.71924249
9CLOCK_20551151_ChIP-Seq_293T_Human2.60165260
10* FOXM1_23109430_ChIP-Seq_U2OS_Human2.59309436
11E2F7_22180533_ChIP-Seq_HELA_Human2.52712443
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.41717565
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.20780408
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.16372444
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14572654
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13133144
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11987724
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06063029
19ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.05276728
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.05137704
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93844290
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.93804448
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90250974
24* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87219127
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86350786
26* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.77980469
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76298429
28ATF3_27146783_Chip-Seq_COLON_Human1.75770767
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73789586
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71203460
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69696402
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.67880708
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.65567979
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64007917
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63780067
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63780067
37* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63313345
38* BRD4_25478319_ChIP-Seq_HGPS_Human1.60080200
39* TFEB_21752829_ChIP-Seq_HELA_Human1.53802847
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53662429
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51899406
42XRN2_22483619_ChIP-Seq_HELA_Human1.51274616
43AR_21909140_ChIP-Seq_LNCAP_Human1.50775439
44ZNF263_19887448_ChIP-Seq_K562_Human1.49157129
45* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48722609
46VDR_21846776_ChIP-Seq_THP-1_Human1.48376629
47* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48320268
48ELK1_19687146_ChIP-ChIP_HELA_Human1.47454806
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.47012733
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.46663948
51* DCP1A_22483619_ChIP-Seq_HELA_Human1.42300117
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41873991
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41661913
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39071144
55TP53_22127205_ChIP-Seq_IMR90_Human1.38869958
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37588270
57MYC_22102868_ChIP-Seq_BL_Human1.37090269
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36122531
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35879845
60CJUN_26792858_Chip-Seq_BT549_Human1.34788252
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34431517
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32535622
63SMC3_22415368_ChIP-Seq_MEFs_Mouse1.32117674
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31122920
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.30741210
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29080767
67RACK7_27058665_Chip-Seq_MCF-7_Human1.27910875
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27278966
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26745359
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.25264387
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24690299
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24154785
73* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23388363
74* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22994417
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22563979
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.21572536
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21207617
78VDR_24763502_ChIP-Seq_THP-1_Human1.19740919
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18666790
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18361636
81* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18077150
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17111435
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16996228
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16886227
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16611685
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16594154
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15498199
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14502771
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13845033
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13633162
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13508542
92* MAF_26560356_Chip-Seq_TH1_Human1.13442845
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.13018222
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.11949045
95* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11476974
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10868046
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10845326
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.10690298
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.10690298
100LXR_22292898_ChIP-Seq_THP-1_Human1.10018420
101* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09841540
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09222524
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.07665141
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07010377
105* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06943311
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05477858
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05188589
108* UTX_26944678_Chip-Seq_JUKART_Human1.04923615
109SA1_22415368_ChIP-Seq_MEFs_Mouse1.04580994
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02630950
111* SPI1_23547873_ChIP-Seq_NB4_Human1.01703276
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01590306
113STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01364736
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01166626
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00957787
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00363978
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99635555
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98045062
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97704235
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97270364
121TTF2_22483619_ChIP-Seq_HELA_Human0.96753963
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96656434
123CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96550507
124IRF8_27001747_Chip-Seq_BMDM_Mouse0.96507194
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.96319541
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96269891
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.95743116
128* RUNX1_22412390_ChIP-Seq_EML_Mouse0.94976398
129MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94446808
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93916076
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93583218
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93393704
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92742530
134* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92485657
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91131271
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86949627
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86845043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.06146239
2MP0003705_abnormal_hypodermis_morpholog4.51968665
3MP0005275_abnormal_skin_tensile3.81915747
4MP0005503_abnormal_tendon_morphology3.62413676
5MP0003279_aneurysm3.47947741
6MP0005623_abnormal_meninges_morphology2.72129968
7MP0001958_emphysema2.60636158
8MP0003566_abnormal_cell_adhesion2.44919837
9MP0005023_abnormal_wound_healing2.44834323
10MP0010352_gastrointestinal_tract_polyps2.31870269
11MP0004272_abnormal_basement_membrane2.20898706
12MP0003091_abnormal_cell_migration2.20797162
13MP0003191_abnormal_cellular_cholesterol2.18689417
14MP0010030_abnormal_orbit_morphology2.17528291
15MP0002877_abnormal_melanocyte_morpholog2.17147456
16MP0006054_spinal_hemorrhage2.07767581
17MP0005257_abnormal_intraocular_pressure1.95302888
18MP0009840_abnormal_foam_cell1.93721923
19MP0009384_cardiac_valve_regurgitation1.91522282
20* MP0000733_abnormal_muscle_development1.80212873
21MP0000858_altered_metastatic_potential1.79673064
22MP0002060_abnormal_skin_morphology1.70309826
23MP0005508_abnormal_skeleton_morphology1.65255447
24MP0001542_abnormal_bone_strength1.61908212
25MP0001243_abnormal_dermal_layer1.60300319
26MP0004510_myositis1.39789943
27* MP0000750_abnormal_muscle_regeneration1.36806220
28MP0002933_joint_inflammation1.35564462
29MP0002295_abnormal_pulmonary_circulatio1.34300327
30MP0001533_abnormal_skeleton_physiology1.33954440
31MP0010307_abnormal_tumor_latency1.32292740
32MP0005390_skeleton_phenotype1.30793415
33MP0006082_CNS_inflammation1.29847956
34MP0005165_increased_susceptibility_to1.29674652
35MP0003828_pulmonary_edema1.27326095
36MP0005076_abnormal_cell_differentiation1.26781421
37MP0001299_abnormal_eye_distance/1.26580267
38MP0003075_altered_response_to1.24526065
39MP0003448_altered_tumor_morphology1.23845304
40MP0003436_decreased_susceptibility_to1.22633193
41MP0008007_abnormal_cellular_replicative1.21474118
42MP0003303_peritoneal_inflammation1.20559307
43MP0009250_abnormal_appendicular_skeleto1.20129270
44MP0008260_abnormal_autophagy1.19884164
45MP0010368_abnormal_lymphatic_system1.19760085
46MP0001849_ear_inflammation1.19651731
47MP0003950_abnormal_plasma_membrane1.19311320
48MP0002896_abnormal_bone_mineralization1.18001192
49MP0009053_abnormal_anal_canal1.17836645
50MP0000013_abnormal_adipose_tissue1.17560622
51MP0001853_heart_inflammation1.16610342
52MP0003300_gastrointestinal_ulcer1.16435815
53MP0005058_abnormal_lysosome_morphology1.14077067
54MP0000343_altered_response_to1.11120753
55MP0000749_muscle_degeneration1.10593286
56MP0000767_abnormal_smooth_muscle1.10047415
57MP0003385_abnormal_body_wall1.08648225
58MP0004808_abnormal_hematopoietic_stem1.07725416
59MP0009780_abnormal_chondrocyte_physiolo1.05032030
60MP0002998_abnormal_bone_remodeling1.04842219
61MP0003045_fibrosis1.02739745
62MP0009333_abnormal_splenocyte_physiolog1.02262474
63MP0005164_abnormal_response_to1.00370668
64MP0004883_abnormal_blood_vessel0.96976255
65MP0002148_abnormal_hypersensitivity_rea0.96580265
66MP0004858_abnormal_nervous_system0.96269568
67MP0002113_abnormal_skeleton_development0.93934545
68MP0003795_abnormal_bone_structure0.93120205
69MP0002168_other_aberrant_phenotype0.92996463
70MP0000163_abnormal_cartilage_morphology0.92101022
71MP0002089_abnormal_postnatal_growth/wei0.90587851
72MP0003942_abnormal_urinary_system0.90082943
73MP0001348_abnormal_lacrimal_gland0.89540665
74MP0004185_abnormal_adipocyte_glucose0.89450006
75* MP0000759_abnormal_skeletal_muscle0.89140388
76MP0000428_abnormal_craniofacial_morphol0.89036901
77MP0002115_abnormal_skeleton_extremities0.87737586
78MP0003186_abnormal_redox_activity0.87607913
79MP0003941_abnormal_skin_development0.86417455
80MP0003172_abnormal_lysosome_physiology0.85783532
81MP0008932_abnormal_embryonic_tissue0.84945970
82MP0003806_abnormal_nucleotide_metabolis0.84702718
83MP0000604_amyloidosis0.83810588
84MP0002108_abnormal_muscle_morphology0.83496839
85MP0005451_abnormal_body_composition0.82725484
86MP0001915_intracranial_hemorrhage0.82702431
87MP0002128_abnormal_blood_circulation0.82615917
88MP0002282_abnormal_trachea_morphology0.81917427
89MP0001879_abnormal_lymphatic_vessel0.81842769
90MP0000762_abnormal_tongue_morphology0.81744092
91MP0005171_absent_coat_pigmentation0.81122429
92MP0001614_abnormal_blood_vessel0.80722298
93MP0000747_muscle_weakness0.79143319
94MP0004957_abnormal_blastocyst_morpholog0.77055053
95MP0000003_abnormal_adipose_tissue0.76779229
96MP0005197_abnormal_uvea_morphology0.76650623
97MP0002419_abnormal_innate_immunity0.75975815
98MP0004947_skin_inflammation0.75891817
99MP0005360_urolithiasis0.75310275
100MP0000685_abnormal_immune_system0.74747544
101MP0000358_abnormal_cell_content/0.73593158
102* MP0004087_abnormal_muscle_fiber0.73564294
103MP0005464_abnormal_platelet_physiology0.71015797
104MP0002932_abnormal_joint_morphology0.70919080
105MP0004197_abnormal_fetal_growth/weight/0.70584432
106MP0000751_myopathy0.70426106
107MP0009785_altered_susceptibility_to0.70133586
108MP0002396_abnormal_hematopoietic_system0.69052831
109MP0005193_abnormal_anterior_eye0.69025212
110MP0000249_abnormal_blood_vessel0.68951663
111MP0002332_abnormal_exercise_endurance0.68946381
112MP0004233_abnormal_muscle_weight0.68262105
113MP0005330_cardiomyopathy0.66982162
114MP0003453_abnormal_keratinocyte_physiol0.65975368
115MP0003755_abnormal_palate_morphology0.65565283
116MP0000350_abnormal_cell_proliferation0.65530679
117MP0005621_abnormal_cell_physiology0.65473436
118MP0005375_adipose_tissue_phenotype0.65395702
119MP0005397_hematopoietic_system_phenotyp0.64968421
120MP0001545_abnormal_hematopoietic_system0.64968421
121MP0009278_abnormal_bone_marrow0.64913293
122MP0002405_respiratory_system_inflammati0.64867068
123MP0000534_abnormal_ureter_morphology0.63995576
124MP0001175_abnormal_lung_morphology0.62999572
125MP0003115_abnormal_respiratory_system0.62145898
126MP0005595_abnormal_vascular_smooth0.61506939
127MP0005166_decreased_susceptibility_to0.61399827
128MP0003693_abnormal_embryo_hatching0.61008447
129MP0000490_abnormal_crypts_of0.60761821
130MP0010386_abnormal_urinary_bladder0.59742387
131MP0000627_abnormal_mammary_gland0.58584227
132MP0005666_abnormal_adipose_tissue0.58184972
133MP0003329_amyloid_beta_deposits0.55494240

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.64492537
2Premature rupture of membranes (HP:0001788)7.55896592
3Vertebral compression fractures (HP:0002953)4.48066134
4Ankle contracture (HP:0006466)4.18451841
5Aortic dissection (HP:0002647)4.13199342
6Peritonitis (HP:0002586)4.10622753
7Shallow orbits (HP:0000586)4.05943476
8Cerebral aneurysm (HP:0004944)4.03743347
9Soft skin (HP:0000977)3.98336390
10Cervical subluxation (HP:0003308)3.90136939
11Dilatation of the ascending aorta (HP:0005111)3.87728179
12Abnormality of dentin (HP:0010299)3.74078076
13Increased connective tissue (HP:0009025)3.71058502
14Aortic aneurysm (HP:0004942)3.62585959
15Spinal rigidity (HP:0003306)3.61835011
16Atrophic scars (HP:0001075)3.58630137
17Wormian bones (HP:0002645)3.58557417
18Biconcave vertebral bodies (HP:0004586)3.56869663
19Abnormality of glycolipid metabolism (HP:0010969)3.39374141
20Abnormality of liposaccharide metabolism (HP:0010968)3.39374141
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.39374141
22Increased density of long bones (HP:0006392)3.36702821
23Fragile skin (HP:0001030)3.28031283
24Osteolytic defects of the hand bones (HP:0009699)3.23017490
25Osteolytic defects of the phalanges of the hand (HP:0009771)3.23017490
26Type 1 muscle fiber predominance (HP:0003803)3.21381260
27Blue sclerae (HP:0000592)3.11953341
28Bladder diverticulum (HP:0000015)3.09409712
29Short nail (HP:0001799)2.86558076
30Genu recurvatum (HP:0002816)2.83996147
31Wrist flexion contracture (HP:0001239)2.79061135
32Reduced subcutaneous adipose tissue (HP:0003758)2.76702593
33Elbow flexion contracture (HP:0002987)2.71127320
34Difficulty climbing stairs (HP:0003551)2.67497018
35Syringomyelia (HP:0003396)2.58247327
36Spinal cord lesions (HP:0100561)2.58247327
37Upper limb amyotrophy (HP:0009129)2.55441110
38Distal upper limb amyotrophy (HP:0007149)2.55441110
39Dysostosis multiplex (HP:0000943)2.53748167
40Neonatal short-limb short stature (HP:0008921)2.52161242
41Abnormality of the calcaneus (HP:0008364)2.51185946
42Abnormality of the acetabulum (HP:0003170)2.50241090
43Scapular winging (HP:0003691)2.49976430
44Mitral valve prolapse (HP:0001634)2.49274033
45Distal lower limb amyotrophy (HP:0008944)2.40985070
46Follicular hyperkeratosis (HP:0007502)2.39345613
47Slender build (HP:0001533)2.39163306
48Broad metatarsal (HP:0001783)2.38488875
49Achilles tendon contracture (HP:0001771)2.30561473
50Abnormal delivery (HP:0001787)2.28759737
51Nuclear cataract (HP:0100018)2.28127650
52Axonal loss (HP:0003447)2.27202055
53Aortic regurgitation (HP:0001659)2.26141861
54Coxa vara (HP:0002812)2.24667966
55Natal tooth (HP:0000695)2.22982874
56Mildly elevated creatine phosphokinase (HP:0008180)2.21217164
57Bowel diverticulosis (HP:0005222)2.19917489
58Trismus (HP:0000211)2.19121814
59Mitral regurgitation (HP:0001653)2.16903163
60Increased variability in muscle fiber diameter (HP:0003557)2.14555585
61Calcaneovalgus deformity (HP:0001848)2.12751907
62Joint stiffness (HP:0001387)2.12470397
63Entropion (HP:0000621)2.12024203
64Vascular tortuosity (HP:0004948)2.11149279
65Abnormality of skeletal muscle fiber size (HP:0012084)2.09032595
66Aneurysm (HP:0002617)2.08534980
67Hand muscle atrophy (HP:0009130)2.07894832
68Delayed cranial suture closure (HP:0000270)2.07117342
69Generalized amyotrophy (HP:0003700)2.06862140
70Thin bony cortex (HP:0002753)2.05969373
71Abnormality of polysaccharide metabolism (HP:0011012)2.04806123
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04806123
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04806123
74Hyperextensible skin (HP:0000974)2.04029872
75Gastrointestinal dysmotility (HP:0002579)2.03645541
76Beaking of vertebral bodies (HP:0004568)2.02903612
77Glucose intolerance (HP:0000833)2.02771110
78Subacute progressive viral hepatitis (HP:0006572)2.02729882
79Mucopolysacchariduria (HP:0008155)2.02542755
80Urinary glycosaminoglycan excretion (HP:0003541)2.02542755
81Ulnar bowing (HP:0003031)2.01859462
82Deviation of the hallux (HP:0010051)2.01732212
83Broad face (HP:0000283)1.99443009
84Mesomelia (HP:0003027)1.98727567
85Spinal cord compression (HP:0002176)1.98702142
86Nonimmune hydrops fetalis (HP:0001790)1.98315070
87Aortic valve stenosis (HP:0001650)1.98241285
88Abnormality of the umbilical cord (HP:0010881)1.97845236
89Round ear (HP:0100830)1.97686604
90Abnormality of the Achilles tendon (HP:0005109)1.97685759
91Abnormality of the peritoneum (HP:0002585)1.97447569
92Hallux valgus (HP:0001822)1.95512849
93Ovoid vertebral bodies (HP:0003300)1.94616013
94Mitral stenosis (HP:0001718)1.94164633
95Abnormal hemoglobin (HP:0011902)1.93781493
96Camptodactyly of toe (HP:0001836)1.93444231
97Radial bowing (HP:0002986)1.92511081
98Cardiovascular calcification (HP:0011915)1.90445038
99Deformed tarsal bones (HP:0008119)1.89726908
100Slender long bone (HP:0003100)1.89201943
101Abnormality of the distal phalanges of the toes (HP:0010182)1.89055585
102Knee flexion contracture (HP:0006380)1.88775943
103Selective tooth agenesis (HP:0001592)1.87574295
104Long toe (HP:0010511)1.87303089
105Breech presentation (HP:0001623)1.87141954
106Overgrowth (HP:0001548)1.86933539
107Vacuolated lymphocytes (HP:0001922)1.83808668
108Ulnar deviation of the wrist (HP:0003049)1.82773510
109Decreased subcutaneous fat (HP:0001002)1.82557990
110Distal lower limb muscle weakness (HP:0009053)1.81612209
111Myocardial infarction (HP:0001658)1.79328683
112Joint laxity (HP:0001388)1.79153863
113Osteopenia (HP:0000938)1.78937371
114Platyspondyly (HP:0000926)1.77882607
115Rough bone trabeculation (HP:0100670)1.77382072
116Arterial tortuosity (HP:0005116)1.76072915
117Abnormality of skull ossification (HP:0002703)1.75132197
118Distal arthrogryposis (HP:0005684)1.75037335
119Delayed closure of the anterior fontanelle (HP:0001476)1.75004891
120Buphthalmos (HP:0000557)1.73472039
121Abnormality of subcutaneous fat tissue (HP:0001001)1.73259190
122Spondylolisthesis (HP:0003302)1.73209662
123Asymmetric septal hypertrophy (HP:0001670)1.72418234
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71841876
125Nemaline bodies (HP:0003798)1.71556247
126Lower limb amyotrophy (HP:0007210)1.70225632
127Amyloidosis (HP:0011034)1.70037311
128Ectopia lentis (HP:0001083)1.66526573
129Absent frontal sinuses (HP:0002688)1.66520569
130Disproportionate tall stature (HP:0001519)1.62077410
131Joint contractures involving the joints of the feet (HP:0100492)1.60862583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.06454408
2NME23.82645097
3TESK23.60604206
4TTN3.57796375
5TESK13.52243346
6LIMK12.88766256
7DDR22.86563876
8IRAK32.75725256
9PKN22.61660972
10MST1R2.53792301
11BMX2.35895048
12PIM22.32045498
13LATS22.31012949
14RPS6KA42.23271643
15ERN12.08095854
16LRRK22.06963033
17MOS1.99986125
18PDGFRA1.81657618
19PAK21.80855135
20SCYL21.71435395
21TRPM71.67404508
22ILK1.58972328
23EEF2K1.57059208
24PAK41.56717152
25MAP3K121.55792224
26MET1.50909942
27GRK71.49352426
28NEK91.37120089
29NTRK11.34117226
30PRPF4B1.27868052
31KDR1.26228585
32EPHA21.26214545
33EIF2AK11.26070041
34STK101.19392818
35BUB11.19190826
36PIK3CG1.17465424
37PTK21.17271329
38PRKD21.11703775
39CDC42BPA1.06343490
40PTK2B1.05995714
41ERBB41.04140589
42PAK11.03030842
43LMTK21.02960649
44MAP3K81.00594660
45MAP2K31.00038604
46EPHB20.99808188
47PTK60.99588119
48TLK10.99030530
49CAMKK20.92325421
50TYK20.90483822
51VRK20.90362383
52NEK10.86684105
53TBK10.86078689
54MAPKAPK30.83488046
55SMG10.80094608
56ERBB30.79269214
57NEK20.79102053
58ROCK10.77757719
59MAP3K110.75847420
60DAPK30.75373342
61SIK10.75198615
62ABL20.74766038
63LATS10.74661703
64MAP2K10.73956588
65BLK0.73921944
66DMPK0.72993975
67ICK0.69846872
68RIPK10.68696772
69MUSK0.68342255
70TAOK20.67841142
71TGFBR10.67538880
72BRAF0.65790348
73FER0.64771989
74MAP3K100.63604352
75MYLK0.63056141
76STK380.62712997
77MAP3K30.60586926
78CDK80.59759182
79STK30.59395393
80GSK3A0.59354195
81JAK30.57602955
82AURKB0.57177477
83MAP3K130.56792378
84ROCK20.56335763
85MAP3K60.55851861
86ADRBK10.55384261
87RPS6KB20.55236206
88KIT0.54770831
89MAP3K140.54374187
90BRSK20.54238006
91CAMKK10.54165541
92CAMK1D0.54146730
93CDK60.54041172
94CDK140.53706401
95RPS6KA20.53620157
96PAK30.52561097
97CDK150.52250358
98PRKG20.52187735
99EPHB10.50358866
100GRK50.50047463
101PIK3CA0.48869072
102MAPKAPK20.48760431
103MTOR0.47482858
104FGFR10.47471754
105MAPK70.47451545
106CDK180.47328678
107CDK11A0.47239450
108EIF2AK30.47050815
109FLT30.46038885
110PDGFRB0.45425102
111CAMK2G0.45310129
112WEE10.44966812
113CSK0.44739559
114PBK0.44672676
115PAK60.44528708
116TGFBR20.44145667
117INSR0.42241195
118AURKA0.41528325
119CLK10.40082149
120CDK70.39527683
121PDPK10.38774773
122DAPK10.37489922
123JAK10.37113336
124PLK10.35439337
125ARAF0.35195402
126TAOK10.34711066
127PRKD10.34558258
128DYRK1B0.34396009
129CDC70.33885757
130TIE10.33272580
131MELK0.32711152
132ZAP700.32188608
133IKBKB0.30341599

Predicted pathways (KEGG)

RankGene SetZ-score
1Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.89582152
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.59017003
3Ribosome_Homo sapiens_hsa030102.50811998
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.41598059
5ECM-receptor interaction_Homo sapiens_hsa045122.38666512
6Focal adhesion_Homo sapiens_hsa045102.33232366
7Shigellosis_Homo sapiens_hsa051312.31798781
8Proteasome_Homo sapiens_hsa030502.24719694
9Proteoglycans in cancer_Homo sapiens_hsa052052.10109786
10Bladder cancer_Homo sapiens_hsa052191.99874836
11p53 signaling pathway_Homo sapiens_hsa041151.94138352
12Malaria_Homo sapiens_hsa051441.93093039
13Small cell lung cancer_Homo sapiens_hsa052221.73395076
14Viral myocarditis_Homo sapiens_hsa054161.67091622
15Adherens junction_Homo sapiens_hsa045201.60868308
16Galactose metabolism_Homo sapiens_hsa000521.60738995
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59220585
18Apoptosis_Homo sapiens_hsa042101.56157901
19Chronic myeloid leukemia_Homo sapiens_hsa052201.54262821
20Pentose phosphate pathway_Homo sapiens_hsa000301.49549826
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49467764
22Prion diseases_Homo sapiens_hsa050201.47934119
23MicroRNAs in cancer_Homo sapiens_hsa052061.47509387
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44574918
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.42197573
26Phagosome_Homo sapiens_hsa041451.41203230
27Salmonella infection_Homo sapiens_hsa051321.39160163
28Sulfur metabolism_Homo sapiens_hsa009201.38955303
29Amoebiasis_Homo sapiens_hsa051461.38463381
30Viral carcinogenesis_Homo sapiens_hsa052031.37096346
31DNA replication_Homo sapiens_hsa030301.30424166
32Cell cycle_Homo sapiens_hsa041101.30412668
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.29476525
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.28694173
35Leishmaniasis_Homo sapiens_hsa051401.27866168
36Antigen processing and presentation_Homo sapiens_hsa046121.26914115
37Lysosome_Homo sapiens_hsa041421.23785416
38Dilated cardiomyopathy_Homo sapiens_hsa054141.22101994
39Legionellosis_Homo sapiens_hsa051341.21334641
40One carbon pool by folate_Homo sapiens_hsa006701.20264963
41Melanoma_Homo sapiens_hsa052181.16693113
42HTLV-I infection_Homo sapiens_hsa051661.16402606
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14907481
44Pertussis_Homo sapiens_hsa051331.13210235
45Pancreatic cancer_Homo sapiens_hsa052121.11723228
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10301044
47TNF signaling pathway_Homo sapiens_hsa046681.09104038
48Fructose and mannose metabolism_Homo sapiens_hsa000511.09079800
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07045528
50TGF-beta signaling pathway_Homo sapiens_hsa043501.04960071
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04693128
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01984479
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00823111
54Toxoplasmosis_Homo sapiens_hsa051451.00788507
55RNA transport_Homo sapiens_hsa030130.99802005
56Platelet activation_Homo sapiens_hsa046110.99783298
57Hepatitis B_Homo sapiens_hsa051610.99526115
58HIF-1 signaling pathway_Homo sapiens_hsa040660.98053491
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97190077
60Osteoclast differentiation_Homo sapiens_hsa043800.93275408
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90336650
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.90046906
63Epstein-Barr virus infection_Homo sapiens_hsa051690.89752239
64Hippo signaling pathway_Homo sapiens_hsa043900.86499483
65Nucleotide excision repair_Homo sapiens_hsa034200.84199585
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83762272
67Tuberculosis_Homo sapiens_hsa051520.82697230
68Glioma_Homo sapiens_hsa052140.82067482
69Systemic lupus erythematosus_Homo sapiens_hsa053220.81972817
70VEGF signaling pathway_Homo sapiens_hsa043700.80426863
71Endocytosis_Homo sapiens_hsa041440.79611413
72Sulfur relay system_Homo sapiens_hsa041220.79275844
73Complement and coagulation cascades_Homo sapiens_hsa046100.77798166
74Measles_Homo sapiens_hsa051620.77239835
75N-Glycan biosynthesis_Homo sapiens_hsa005100.76967976
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73259639
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.73231277
78Other glycan degradation_Homo sapiens_hsa005110.71256079
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70886594
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70253797
81Protein digestion and absorption_Homo sapiens_hsa049740.69319470
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67952133
83Protein export_Homo sapiens_hsa030600.67217407
84Thyroid cancer_Homo sapiens_hsa052160.66702528
85Prostate cancer_Homo sapiens_hsa052150.65211320
86Influenza A_Homo sapiens_hsa051640.65003684
87Colorectal cancer_Homo sapiens_hsa052100.63149211
88Pathways in cancer_Homo sapiens_hsa052000.62735888
89Rap1 signaling pathway_Homo sapiens_hsa040150.62268036
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61941663
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61336966
92Acute myeloid leukemia_Homo sapiens_hsa052210.60677840
93Renin-angiotensin system_Homo sapiens_hsa046140.60275335
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56387912
95Spliceosome_Homo sapiens_hsa030400.55665820
96Tight junction_Homo sapiens_hsa045300.55451971
97Staphylococcus aureus infection_Homo sapiens_hsa051500.55073956
98Fatty acid elongation_Homo sapiens_hsa000620.54210565
99Base excision repair_Homo sapiens_hsa034100.52761340
100Renal cell carcinoma_Homo sapiens_hsa052110.52653689
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50563995
102Vibrio cholerae infection_Homo sapiens_hsa051100.50475330
103African trypanosomiasis_Homo sapiens_hsa051430.49841213
104Mineral absorption_Homo sapiens_hsa049780.49767865
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49741488
106Pyrimidine metabolism_Homo sapiens_hsa002400.47896046
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47740655
108Non-small cell lung cancer_Homo sapiens_hsa052230.47256745
109Biosynthesis of amino acids_Homo sapiens_hsa012300.45893216
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45384043
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.45165596
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.43031469
113Allograft rejection_Homo sapiens_hsa053300.42522314
114Sphingolipid metabolism_Homo sapiens_hsa006000.41806152
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41726946
116Carbon metabolism_Homo sapiens_hsa012000.41690872
117Graft-versus-host disease_Homo sapiens_hsa053320.40743077
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.40469401
119Mismatch repair_Homo sapiens_hsa034300.39353099
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38965339
121Hematopoietic cell lineage_Homo sapiens_hsa046400.38608263
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38349924
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37925291
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.37297235
125mTOR signaling pathway_Homo sapiens_hsa041500.36898325
126Rheumatoid arthritis_Homo sapiens_hsa053230.36832223
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36554712
128Glutathione metabolism_Homo sapiens_hsa004800.36177264

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