LGALS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)9.09004828
2regulation of sequestering of triglyceride (GO:0010889)8.81881696
3white fat cell differentiation (GO:0050872)8.11869021
4triglyceride catabolic process (GO:0019433)7.86969760
5valine metabolic process (GO:0006573)7.66450180
6brown fat cell differentiation (GO:0050873)7.64375435
7biotin metabolic process (GO:0006768)7.38792306
8neutral lipid catabolic process (GO:0046461)7.06462486
9acylglycerol catabolic process (GO:0046464)7.06462486
10neutrophil activation involved in immune response (GO:0002283)6.08401058
11fatty acid transmembrane transport (GO:1902001)6.06044767
12triglyceride biosynthetic process (GO:0019432)6.00724293
13lipid particle organization (GO:0034389)5.87028709
14acylglycerol biosynthetic process (GO:0046463)5.76416301
15neutral lipid biosynthetic process (GO:0046460)5.76416301
16carnitine shuttle (GO:0006853)5.76060124
17negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.50740800
18positive regulation of fatty acid oxidation (GO:0046321)5.40177179
19regulation of cholesterol storage (GO:0010885)5.35206027
20glycerolipid catabolic process (GO:0046503)5.29808424
21positive regulation of fatty acid beta-oxidation (GO:0032000)5.25635697
22branched-chain amino acid metabolic process (GO:0009081)5.20112147
23branched-chain amino acid catabolic process (GO:0009083)5.15502921
24fatty acid beta-oxidation (GO:0006635)5.13907281
25lipid storage (GO:0019915)5.05495308
26fatty-acyl-CoA biosynthetic process (GO:0046949)5.03130908
27thioester biosynthetic process (GO:0035384)4.93834044
28acyl-CoA biosynthetic process (GO:0071616)4.93834044
29long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.84652699
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.84100084
31fatty-acyl-CoA metabolic process (GO:0035337)4.83804176
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.81912626
33regulation of platelet aggregation (GO:0090330)4.72213530
34carnitine transmembrane transport (GO:1902603)4.62711532
35coenzyme A biosynthetic process (GO:0015937)4.55493083
36triglyceride metabolic process (GO:0006641)4.54771266
37response to dietary excess (GO:0002021)4.54717015
38fatty acid oxidation (GO:0019395)4.50030132
39lipid oxidation (GO:0034440)4.40789432
40fatty acid catabolic process (GO:0009062)4.40578525
41leukocyte migration involved in inflammatory response (GO:0002523)4.31229283
42acylglycerol metabolic process (GO:0006639)4.30468891
43neutral lipid metabolic process (GO:0006638)4.24291038
44regulation of fatty acid oxidation (GO:0046320)4.20830337
45amino-acid betaine transport (GO:0015838)4.20719196
46carnitine transport (GO:0015879)4.20719196
47thrombin receptor signaling pathway (GO:0070493)4.20308953
48negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.18726264
49regulation of platelet activation (GO:0010543)4.18560678
50adenosine receptor signaling pathway (GO:0001973)4.10242880
51fatty acid homeostasis (GO:0055089)4.08495417
52angiogenesis involved in wound healing (GO:0060055)4.03812024
53tricarboxylic acid metabolic process (GO:0072350)4.01931585
54negative regulation of protein autophosphorylation (GO:0031953)4.01710892
55negative regulation of homotypic cell-cell adhesion (GO:0034111)4.01502306
56acetyl-CoA metabolic process (GO:0006084)3.95429860
57negative regulation of lipid storage (GO:0010888)3.93507376
58lipoxygenase pathway (GO:0019372)3.92699586
59regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.92208772
60pentose-phosphate shunt (GO:0006098)3.90986538
61protein neddylation (GO:0045116)3.90367337
62phospholipid homeostasis (GO:0055091)3.90101162
63cellular response to lithium ion (GO:0071285)3.87896100
64NADH metabolic process (GO:0006734)3.87663429
65regulation of fatty acid beta-oxidation (GO:0031998)3.87539806
66alpha-linolenic acid metabolic process (GO:0036109)3.87322278
67NADPH regeneration (GO:0006740)3.86779992
68positive regulation of fatty acid metabolic process (GO:0045923)3.85677823
69transcytosis (GO:0045056)3.85421767
70negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.80751937
71regulation of macrophage derived foam cell differentiation (GO:0010743)3.80055925
72regulation of cAMP-dependent protein kinase activity (GO:2000479)3.79765963
73neutrophil activation (GO:0042119)3.78952941
74positive regulation of glomerulus development (GO:0090193)3.78147619
75protein heterotrimerization (GO:0070208)3.75497463
76coenzyme A metabolic process (GO:0015936)3.74015158
77negative regulation of granulocyte differentiation (GO:0030853)3.71923790
78intracellular lipid transport (GO:0032365)3.71386629
79positive regulation of glucose import (GO:0046326)3.67345330
80glycerol metabolic process (GO:0006071)3.66818033
81positive regulation of lipid catabolic process (GO:0050996)3.64423560
82negative regulation of platelet activation (GO:0010544)3.64392725
83negative regulation of norepinephrine secretion (GO:0010700)3.61825101
84positive regulation of cellular response to insulin stimulus (GO:1900078)3.61361421
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.60132724
86regulation of cholesterol efflux (GO:0010874)3.58617660
87platelet aggregation (GO:0070527)3.58386495
88positive regulation of lipid storage (GO:0010884)3.54649355
89diacylglycerol metabolic process (GO:0046339)3.54530307
90growth hormone receptor signaling pathway (GO:0060396)3.53288719
91L-serine transport (GO:0015825)3.47192445
92negative regulation of phagocytosis (GO:0050765)3.46124569
93plasma lipoprotein particle clearance (GO:0034381)3.44993125
94oxaloacetate metabolic process (GO:0006107)3.43070657
95long-chain fatty acid transport (GO:0015909)3.41316113
96blood coagulation, intrinsic pathway (GO:0007597)3.40987696
97negative regulation of metanephros development (GO:0072217)3.40275176
98negative regulation of macrophage differentiation (GO:0045650)3.38934331
99regulation of glycogen (starch) synthase activity (GO:2000465)3.38794903
100cellular response to epinephrine stimulus (GO:0071872)3.38484379
101positive regulation of mast cell activation (GO:0033005)3.36695950
102tricarboxylic acid cycle (GO:0006099)3.35207638
103positive regulation of cholesterol efflux (GO:0010875)3.34421233
104ovulation from ovarian follicle (GO:0001542)3.34392073
105negative regulation of response to food (GO:0032096)3.32925926
106negative regulation of appetite (GO:0032099)3.32925926
107regulation of integrin-mediated signaling pathway (GO:2001044)3.32274627
108granulocyte activation (GO:0036230)3.30623379
109negative regulation of T cell apoptotic process (GO:0070233)3.29778268
110regulation of lipoprotein metabolic process (GO:0050746)3.28742803
111adaptation of signaling pathway (GO:0023058)3.28706518
112monocarboxylic acid catabolic process (GO:0072329)3.28601437
113phosphatidic acid metabolic process (GO:0046473)3.28163008
114phosphatidic acid biosynthetic process (GO:0006654)3.28163008
115fat cell differentiation (GO:0045444)3.27645341
116positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.27446687
117regulation of lipid storage (GO:0010883)3.26119291
118positive regulation of sterol transport (GO:0032373)3.25931936
119positive regulation of cholesterol transport (GO:0032376)3.25931936
120negative regulation of erythrocyte differentiation (GO:0045647)3.25311644
121regulation of triglyceride biosynthetic process (GO:0010866)3.23980073
122negative regulation of gluconeogenesis (GO:0045721)3.23616343
123cellular lipid catabolic process (GO:0044242)3.23211420
124CDP-diacylglycerol biosynthetic process (GO:0016024)3.22690994
125ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.22172359
126nucleoside bisphosphate biosynthetic process (GO:0033866)3.22172359
127purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.22172359
128regulation of triglyceride catabolic process (GO:0010896)3.16223433
129extracellular fibril organization (GO:0043206)3.15939737
130CDP-diacylglycerol metabolic process (GO:0046341)3.14608160
131low-density lipoprotein particle remodeling (GO:0034374)3.13313014
132positive regulation of receptor recycling (GO:0001921)3.12994071
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12917476
134linoleic acid metabolic process (GO:0043651)3.11659254
135G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.05178203
136fibril organization (GO:0097435)2.94271925
137negative regulation of stress fiber assembly (GO:0051497)2.92738578
138megakaryocyte development (GO:0035855)2.92469866
139positive regulation of cellular amide metabolic process (GO:0034250)2.91694615
140autophagic vacuole fusion (GO:0000046)2.87430450
141positive regulation of gamma-delta T cell activation (GO:0046645)2.85902631
142regulation of homotypic cell-cell adhesion (GO:0034110)2.85852261
143leukocyte degranulation (GO:0043299)2.85067222
144G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.84935299
145regulation of mast cell degranulation (GO:0043304)2.83334281
146cellular extravasation (GO:0045123)2.80911159
147response to hydroperoxide (GO:0033194)2.79725799
148platelet degranulation (GO:0002576)2.79598061
149endothelium development (GO:0003158)2.76492124
150response to epinephrine (GO:0071871)2.76473492
151fatty acid elongation (GO:0030497)2.73051086
152positive regulation of endothelial cell differentiation (GO:0045603)2.72962876
153regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.70998014
154purinergic nucleotide receptor signaling pathway (GO:0035590)2.69851195
155negative regulation of thymocyte apoptotic process (GO:0070244)2.69813254
156platelet activation (GO:0030168)2.69286604
157phagocytosis, recognition (GO:0006910)2.67729949
158negative regulation of protein localization to plasma membrane (GO:1903077)2.66552898
159regulation of sterol transport (GO:0032371)2.66531206
160regulation of cholesterol transport (GO:0032374)2.66531206
161negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.66141634
162purinergic receptor signaling pathway (GO:0035587)2.65187677
163triglyceride homeostasis (GO:0070328)2.64473077
164acylglycerol homeostasis (GO:0055090)2.64473077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.46684252
2CLOCK_20551151_ChIP-Seq_293T_Human4.46375462
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.13128830
4SCL_19346495_ChIP-Seq_HPC-7_Human3.83634855
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.69504376
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.56682627
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.43396921
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80078559
9LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.70078474
10GATA1_19941826_ChIP-Seq_K562_Human2.58271365
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.54816626
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.53045390
13* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.51068921
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.50591685
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.42118610
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40804013
17SPI1_23127762_ChIP-Seq_K562_Human2.36574267
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31957167
19GATA1_19941827_ChIP-Seq_MEL_Mouse2.30107492
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25290460
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.23989792
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22936259
23GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.22537565
24GATA1_22025678_ChIP-Seq_K562_Human2.22256065
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21909113
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.20446361
27GATA1_22383799_ChIP-Seq_G1ME_Mouse2.19883238
28GATA2_19941826_ChIP-Seq_K562_Human2.18140918
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.12375900
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.12164901
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07661016
32PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.06419429
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.06189617
34VDR_24763502_ChIP-Seq_THP-1_Human2.02810789
35IRF8_27001747_Chip-Seq_BMDM_Mouse2.02678278
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse15.1495745
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98989350
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86245952
39* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82740910
40RUNX_20019798_ChIP-Seq_JUKART_Human1.82003358
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75291606
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74478010
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71739619
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70401242
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67144242
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64323112
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62671071
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61355906
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59625005
50* SPI1_23547873_ChIP-Seq_NB4_Human1.53766738
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49471751
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46985368
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46070619
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.44439460
55UTX_26944678_Chip-Seq_JUKART_Human1.40379243
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39556172
57GATA1_19941827_ChIP-Seq_MEL86_Mouse1.39399139
58VDR_21846776_ChIP-Seq_THP-1_Human1.37426154
59SPI1_20517297_ChIP-Seq_HL60_Human1.33965772
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33727446
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31590103
62* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30739432
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30451353
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29652503
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.28048642
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27363298
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26159630
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.25718624
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.25718624
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22383103
71MYB_26560356_Chip-Seq_TH2_Human1.19600631
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19479301
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18959691
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.18440841
75CJUN_26792858_Chip-Seq_BT549_Human1.18274501
76HTT_18923047_ChIP-ChIP_STHdh_Human1.18211464
77MAF_26560356_Chip-Seq_TH1_Human1.17166448
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16550679
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.15779608
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14809850
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14465705
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.14324490
83NCOR1_26117541_ChIP-Seq_K562_Human1.14019796
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.13563887
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11995210
86STAT1_20625510_ChIP-Seq_HELA_Human1.11117676
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11013295
88SOX2_20726797_ChIP-Seq_SW620_Human1.10832857
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10471864
90TCF7_22412390_ChIP-Seq_EML_Mouse1.10239282
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09962768
92MYB_26560356_Chip-Seq_TH1_Human1.09422542
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08222956
94KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07932659
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07899807
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07515973
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07495425
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.05864462
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04612174
100EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04441927
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02011286
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.00840633
103VDR_24787735_ChIP-Seq_THP-1_Human1.00593857
104RXR_22108803_ChIP-Seq_LS180_Human1.00535215
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00519056
106GATA4_25053715_ChIP-Seq_YYC3_Human0.99011334
107ZNF263_19887448_ChIP-Seq_K562_Human0.98833369
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97401438
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.96699564
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95764742
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95301072
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95163486
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95091523
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94552581
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94515997
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94228499
117PU_27001747_Chip-Seq_BMDM_Mouse0.94053327
118GATA3_27048872_Chip-Seq_THYMUS_Human0.92849936
119ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92255868
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92032509
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91894966
122BCAT_22108803_ChIP-Seq_LS180_Human0.90795807
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.90333566
124* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90207799
125ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89964434
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89596412
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89007241
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86895831
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85765843
130BCL6_27268052_Chip-Seq_Bcells_Human0.85561443
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84996608
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84996608
133TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83255322
134GATA3_26560356_Chip-Seq_TH2_Human0.82676043
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82199797
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81244672
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.78860558
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78376683
139IRF8_22096565_ChIP-ChIP_GC-B_Human0.77210746
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75986242
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.74156094
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.74097307
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73691660
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73277624
145HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72957574
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.70563962
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.70537780
148CDX2_20551321_ChIP-Seq_CACO-2_Human0.70160630
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68309187
150SALL1_21062744_ChIP-ChIP_HESCs_Human0.66299518
151ERG_20517297_ChIP-Seq_VCAP_Human0.63430782
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.63222045
153GATA3_21878914_ChIP-Seq_MCF-7_Human0.62726268
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62149460
155P300_27058665_Chip-Seq_ZR-75-30cells_Human0.61717661
156FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61265747
157TP63_22573176_ChIP-Seq_HFKS_Human0.60716877
158NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.60110827
159NR3C1_23031785_ChIP-Seq_PC12_Mouse0.59991224
160AHR_22903824_ChIP-Seq_MCF-7_Human0.57833144
161CEBPB_22108803_ChIP-Seq_LS180_Human0.57248712
162ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.56950795
163* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56394621
164JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56204262
165CBP_20019798_ChIP-Seq_JUKART_Human0.55840332
166IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.55840332
167RACK7_27058665_Chip-Seq_MCF-7_Human0.55738206
168WT1_25993318_ChIP-Seq_PODOCYTE_Human0.54997412
169EZH2_18974828_ChIP-Seq_MESCs_Mouse0.54728201
170RNF2_18974828_ChIP-Seq_MESCs_Mouse0.54728201
171RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.54686138
172* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.53774768
173AR_25329375_ChIP-Seq_VCAP_Human0.53606293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.54613559
2MP0005464_abnormal_platelet_physiology5.71767412
3MP0005666_abnormal_adipose_tissue5.61290497
4MP0004185_abnormal_adipocyte_glucose5.09618406
5MP0004130_abnormal_muscle_cell4.88864474
6MP0005375_adipose_tissue_phenotype4.14765684
7MP0008438_abnormal_cutaneous_collagen3.77341572
8MP0000013_abnormal_adipose_tissue3.47076617
9MP0002971_abnormal_brown_adipose3.27826249
10MP0002876_abnormal_thyroid_physiology3.23557982
11MP0002837_dystrophic_cardiac_calcinosis3.16286077
12MP0000003_abnormal_adipose_tissue2.96361567
13MP0005275_abnormal_skin_tensile2.73431342
14MP0009115_abnormal_fat_cell2.69801275
15MP0010329_abnormal_lipoprotein_level2.66223142
16MP0005334_abnormal_fat_pad2.61939076
17MP0003303_peritoneal_inflammation2.44546253
18MP0002970_abnormal_white_adipose2.29157742
19MP0003191_abnormal_cellular_cholesterol2.11243985
20MP0002118_abnormal_lipid_homeostasis2.10811226
21MP0000465_gastrointestinal_hemorrhage2.10702576
22MP0003959_abnormal_lean_body2.08990782
23MP0005535_abnormal_body_temperature2.07427006
24MP0001661_extended_life_span1.94821951
25MP0003011_delayed_dark_adaptation1.94340102
26MP0003436_decreased_susceptibility_to1.92750303
27MP0005365_abnormal_bile_salt1.92746927
28MP0005083_abnormal_biliary_tract1.81338702
29MP0001881_abnormal_mammary_gland1.79458222
30MP0001545_abnormal_hematopoietic_system1.77416258
31MP0005397_hematopoietic_system_phenotyp1.77416258
32MP0005448_abnormal_energy_balance1.77196276
33MP0001835_abnormal_antigen_presentation1.72291416
34MP0004272_abnormal_basement_membrane1.63980232
35MP0002078_abnormal_glucose_homeostasis1.59952856
36MP0001533_abnormal_skeleton_physiology1.57593702
37MP0009780_abnormal_chondrocyte_physiolo1.54969302
38MP0003724_increased_susceptibility_to1.54538826
39MP0005452_abnormal_adipose_tissue1.54531735
40MP0003705_abnormal_hypodermis_morpholog1.54178549
41MP0003186_abnormal_redox_activity1.52122664
42MP0002419_abnormal_innate_immunity1.51010802
43MP0005167_abnormal_blood-brain_barrier1.45985593
44MP0005000_abnormal_immune_tolerance1.43947928
45MP0001851_eye_inflammation1.40159203
46MP0002796_impaired_skin_barrier1.38390579
47MP0002254_reproductive_system_inflammat1.34840344
48MP0002132_abnormal_respiratory_system1.34050475
49MP0002909_abnormal_adrenal_gland1.33414966
50MP0002148_abnormal_hypersensitivity_rea1.30031758
51MP0000858_altered_metastatic_potential1.28348430
52MP0002060_abnormal_skin_morphology1.28054436
53MP0000249_abnormal_blood_vessel1.27875770
54MP0000609_abnormal_liver_physiology1.25884522
55MP0005671_abnormal_response_to1.24036132
56MP0005025_abnormal_response_to1.22473471
57MP0004510_myositis1.20684113
58MP0001501_abnormal_sleep_pattern1.13432714
59MP0003300_gastrointestinal_ulcer1.13419644
60MP0002723_abnormal_immune_serum1.12038446
61MP0003828_pulmonary_edema1.11278420
62MP0002420_abnormal_adaptive_immunity1.10766599
63MP0002398_abnormal_bone_marrow1.10276234
64MP0001819_abnormal_immune_cell1.08642098
65MP0010155_abnormal_intestine_physiology1.08376368
66MP0006138_congestive_heart_failure1.06541338
67MP0001800_abnormal_humoral_immune1.06167039
68MP0003690_abnormal_glial_cell1.04415799
69MP0002452_abnormal_antigen_presenting1.04214097
70MP0005645_abnormal_hypothalamus_physiol1.03463651
71MP0003075_altered_response_to1.02543572
72MP0009785_altered_susceptibility_to1.01526625
73MP0003953_abnormal_hormone_level0.99199859
74MP0003638_abnormal_response/metabolism_0.98688129
75MP0004084_abnormal_cardiac_muscle0.98371169
76MP0008961_abnormal_basal_metabolism0.96182081
77MP0005647_abnormal_sex_gland0.95946873
78MP0002139_abnormal_hepatobiliary_system0.95882039
79MP0003045_fibrosis0.95762089
80MP0004947_skin_inflammation0.95538939
81MP0002638_abnormal_pupillary_reflex0.93739695
82MP0001666_abnormal_nutrient_absorption0.93674033
83MP0000685_abnormal_immune_system0.93423910
84MP0006036_abnormal_mitochondrial_physio0.93167877
85MP0008775_abnormal_heart_ventricle0.92849480
86MP0005387_immune_system_phenotype0.92742273
87MP0001790_abnormal_immune_system0.92742273
88MP0000689_abnormal_spleen_morphology0.92660695
89MP0004883_abnormal_blood_vessel0.91348399
90MP0001663_abnormal_digestive_system0.90064510
91MP0008260_abnormal_autophagy0.89959460
92MP0001845_abnormal_inflammatory_respons0.88259507
93MP0005379_endocrine/exocrine_gland_phen0.88006631
94MP0001944_abnormal_pancreas_morphology0.83544407
95MP0009764_decreased_sensitivity_to0.83070213
96MP0002877_abnormal_melanocyte_morpholog0.83039252
97MP0003566_abnormal_cell_adhesion0.82137177
98MP0002722_abnormal_immune_system0.81978818
99MP0002998_abnormal_bone_remodeling0.81542775
100MP0001756_abnormal_urination0.81086765
101MP0002429_abnormal_blood_cell0.78939108
102MP0003646_muscle_fatigue0.78633067
103MP0009642_abnormal_blood_homeostasis0.78551718
104MP0009643_abnormal_urine_homeostasis0.78398180
105MP0004036_abnormal_muscle_relaxation0.78276842
106MP0000716_abnormal_immune_system0.78058115
107MP0001764_abnormal_homeostasis0.77893308
108MP0003948_abnormal_gas_homeostasis0.75686628
109MP0003879_abnormal_hair_cell0.75331279
110MP0001727_abnormal_embryo_implantation0.75304759
111MP0005584_abnormal_enzyme/coenzyme_acti0.75097297
112MP0009278_abnormal_bone_marrow0.75094603
113MP0002166_altered_tumor_susceptibility0.73976635
114MP0003866_abnormal_defecation0.73282844
115MP0008872_abnormal_physiological_respon0.73245996
116MP0002405_respiratory_system_inflammati0.71937576
117MP0005620_abnormal_muscle_contractility0.71418125
118MP0005319_abnormal_enzyme/_coenzyme0.70685538
119MP0001544_abnormal_cardiovascular_syste0.70150133
120MP0005385_cardiovascular_system_phenoty0.70150133
121MP0000343_altered_response_to0.69078463
122MP0005164_abnormal_response_to0.68876708
123MP0008874_decreased_physiological_sensi0.68663461
124MP0003950_abnormal_plasma_membrane0.68392603
125MP0003868_abnormal_feces_composition0.67942913
126MP0002693_abnormal_pancreas_physiology0.67881109
127MP0009765_abnormal_xenobiotic_induced0.67239016
128MP0010234_abnormal_vibrissa_follicle0.67136576
129MP0005390_skeleton_phenotype0.65646518
130MP0000750_abnormal_muscle_regeneration0.64635893
131MP0002168_other_aberrant_phenotype0.61765141
132MP0005332_abnormal_amino_acid0.60778831
133MP0000759_abnormal_skeletal_muscle0.59807733
134MP0002006_tumorigenesis0.59677069
135MP0004147_increased_porphyrin_level0.58716492
136MP0002332_abnormal_exercise_endurance0.58513278
137MP0003221_abnormal_cardiomyocyte_apopto0.57940616
138MP0004087_abnormal_muscle_fiber0.56440020
139MP0004782_abnormal_surfactant_physiolog0.55486228
140MP0002295_abnormal_pulmonary_circulatio0.54763033
141MP0005220_abnormal_exocrine_pancreas0.53937695
142MP0002009_preneoplasia0.53801814
143MP0001879_abnormal_lymphatic_vessel0.53740734
144MP0009672_abnormal_birth_weight0.53288575
145MP0000427_abnormal_hair_cycle0.52375392
146MP0001177_atelectasis0.51892643
147MP0000230_abnormal_systemic_arterial0.50760075
148MP0000627_abnormal_mammary_gland0.49723389
149MP0002972_abnormal_cardiac_muscle0.48108644
150MP0004264_abnormal_extraembryonic_tissu0.46769458
151MP0003283_abnormal_digestive_organ0.46249682
152MP0005501_abnormal_skin_physiology0.45899871
153MP0000681_abnormal_thyroid_gland0.44504601
154MP0005076_abnormal_cell_differentiation0.43976968
155MP0005084_abnormal_gallbladder_morpholo0.43321035
156MP0009763_increased_sensitivity_to0.42088248
157MP0005058_abnormal_lysosome_morphology0.41857100
158MP0002069_abnormal_eating/drinking_beha0.41419590
159MP0008004_abnormal_stomach_pH0.41136953

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.77418563
2Oligomenorrhea (HP:0000876)8.94912389
3Increased mean platelet volume (HP:0011877)8.12962399
4Abnormal platelet volume (HP:0011876)7.95750902
5Menorrhagia (HP:0000132)7.48448359
6Petechiae (HP:0000967)7.45921480
7Acanthosis nigricans (HP:0000956)7.14237217
8Purpura (HP:0000979)6.84704900
9Hypertriglyceridemia (HP:0002155)6.21552049
10Epistaxis (HP:0000421)6.20325434
11Hyperglycinuria (HP:0003108)6.17214881
12Insulin-resistant diabetes mellitus (HP:0000831)6.06765188
13Gingival bleeding (HP:0000225)5.15093302
14Abnormality of serine family amino acid metabolism (HP:0010894)4.86962092
15Abnormality of glycine metabolism (HP:0010895)4.86962092
16Hypoglycemic coma (HP:0001325)4.69195931
17Long foot (HP:0001833)4.43563215
18Myoglobinuria (HP:0002913)4.34939606
19Ketoacidosis (HP:0001993)4.32261041
20Abnormal platelet function (HP:0011869)4.27865162
21Impaired platelet aggregation (HP:0003540)4.27865162
22Insulin resistance (HP:0000855)4.26925527
23Spontaneous hematomas (HP:0007420)4.17263090
24Abnormality of the heme biosynthetic pathway (HP:0010472)4.03072821
25Abnormality of fatty-acid metabolism (HP:0004359)3.88118504
26Growth hormone excess (HP:0000845)3.86735379
27Complement deficiency (HP:0004431)3.82607939
28Increased muscle lipid content (HP:0009058)3.81076315
29Reduced subcutaneous adipose tissue (HP:0003758)3.76231214
30Abnormality of proline metabolism (HP:0010907)3.73936995
31Hydroxyprolinuria (HP:0003080)3.73936995
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.72864367
33Hepatosplenomegaly (HP:0001433)3.65522410
34Ketosis (HP:0001946)3.61162874
35Difficulty running (HP:0009046)3.60807441
36Bone cyst (HP:0012062)3.44170722
37Abnormality of macrophages (HP:0004311)3.38331365
38Pigmentary retinal degeneration (HP:0001146)3.24937177
39Rhabdomyolysis (HP:0003201)3.24220257
40Eczematoid dermatitis (HP:0000976)3.22074325
41Hyperglycemia (HP:0003074)3.16149044
42Abnormality of dicarboxylic acid metabolism (HP:0010995)3.15223149
43Dicarboxylic aciduria (HP:0003215)3.15223149
44Polycythemia (HP:0001901)3.15070694
45Subcapsular cataract (HP:0000523)3.15032693
46Paralysis (HP:0003470)3.14543601
47Stomatitis (HP:0010280)3.08387481
48Decreased subcutaneous fat (HP:0001002)3.04498206
49Hyperglycinemia (HP:0002154)3.04090721
50Poikilocytosis (HP:0004447)3.02984360
51Large hands (HP:0001176)3.01664265
52Thyroid-stimulating hormone excess (HP:0002925)3.00809565
53Nausea (HP:0002018)2.99569433
54Multiple enchondromatosis (HP:0005701)2.97676722
55Pancreatitis (HP:0001733)2.94697612
56Increased connective tissue (HP:0009025)2.90085927
57Abnormality of the common coagulation pathway (HP:0010990)2.88330019
58Bruising susceptibility (HP:0000978)2.88133807
59Hyperthyroidism (HP:0000836)2.86516909
60Hypoalphalipoproteinemia (HP:0003233)2.86313000
61Generalized aminoaciduria (HP:0002909)2.84116052
62Epidermoid cyst (HP:0200040)2.83357975
63Prenatal maternal abnormality (HP:0002686)2.81490214
64Hyperpituitarism (HP:0010514)2.78417698
65Abnormality of subcutaneous fat tissue (HP:0001001)2.78159355
66Acanthocytosis (HP:0001927)2.75566077
67Recurrent abscess formation (HP:0002722)2.73867056
68Conjunctival telangiectasia (HP:0000524)2.72302685
69Dyschromatopsia (HP:0007641)2.71420403
70Myocardial infarction (HP:0001658)2.69613296
71Hypoglycemic seizures (HP:0002173)2.67168697
72Hemorrhage of the eye (HP:0011885)2.64453873
73Abnormality of complement system (HP:0005339)2.62852409
74Abnormal pupillary function (HP:0007686)2.59509819
75Right ventricular cardiomyopathy (HP:0011663)2.53482956
76Chronic obstructive pulmonary disease (HP:0006510)2.51619363
77Obstructive lung disease (HP:0006536)2.51619363
78Hyperammonemia (HP:0001987)2.51036675
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.45643436
80Limb hypertonia (HP:0002509)2.45431603
81Elevated erythrocyte sedimentation rate (HP:0003565)2.43468094
82Episodic fever (HP:0001954)2.41860155
83Abnormality of iron homeostasis (HP:0011031)2.41815890
84Increased IgM level (HP:0003496)2.41530788
85Recurrent bacterial skin infections (HP:0005406)2.40804076
86Spinal rigidity (HP:0003306)2.39139236
87Abnormal hemoglobin (HP:0011902)2.37591036
88Toxemia of pregnancy (HP:0100603)2.35756274
89Polyphagia (HP:0002591)2.29958883
90Abnormality of purine metabolism (HP:0004352)2.29904906
91Follicular hyperkeratosis (HP:0007502)2.29370609
92Ankle contracture (HP:0006466)2.28819354
93Abnormality of alanine metabolism (HP:0010916)2.28467146
94Hyperalaninemia (HP:0003348)2.28467146
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28467146
96Accelerated skeletal maturation (HP:0005616)2.27947123
97Hyperinsulinemic hypoglycemia (HP:0000825)2.27323355
98Abnormal cartilage morphology (HP:0002763)2.26952556
99Myositis (HP:0100614)2.26894075
100Joint hemorrhage (HP:0005261)2.24632356
101Broad metatarsal (HP:0001783)2.23822894
102Increased serum ferritin (HP:0003281)2.23592386
103Encephalitis (HP:0002383)2.23297764
104Hepatic necrosis (HP:0002605)2.21656477
105Increased variability in muscle fiber diameter (HP:0003557)2.20179890
106Type 1 muscle fiber predominance (HP:0003803)2.18686766
107Brushfield spots (HP:0001088)2.18562007
108Tetraparesis (HP:0002273)2.17301519
109Symptomatic seizures (HP:0011145)2.15844205
110Skin nodule (HP:0200036)2.15638701
111Inflammation of the large intestine (HP:0002037)2.13289673
112Maternal diabetes (HP:0009800)2.11212725
113Lipoatrophy (HP:0100578)2.10900014
114Abnormality of lateral ventricle (HP:0030047)2.10848291
115Increased density of long bones (HP:0006392)2.10494646
116Polygenic inheritance (HP:0010982)2.06925619
117Joint swelling (HP:0001386)2.06257372
118Rectal prolapse (HP:0002035)2.04877399
119Ileus (HP:0002595)2.03799725
120Abnormality of transition element cation homeostasis (HP:0011030)2.03388169
121Amyloidosis (HP:0011034)2.02302440
122Hypercortisolism (HP:0001578)2.02030636
123Cerebral aneurysm (HP:0004944)2.01613225
124Dysostosis multiplex (HP:0000943)2.00891017
125Glucose intolerance (HP:0000833)2.00421712
126Prominent supraorbital ridges (HP:0000336)1.99235615
127Clitoromegaly (HP:0000057)1.99021500
128Orchitis (HP:0100796)1.98159550
129Enlarged penis (HP:0000040)1.97402199
130Gastrointestinal inflammation (HP:0004386)1.97290222
131Polar cataract (HP:0010696)1.92430994
132Facial diplegia (HP:0001349)1.89589912
133Turricephaly (HP:0000262)1.89458762
134Hyperuricemia (HP:0002149)1.88969756
135Increased purine levels (HP:0004368)1.88969756
136Hyperlipoproteinemia (HP:0010980)1.88646690
137Muscle fiber splitting (HP:0003555)1.88437299
138Acute hepatic failure (HP:0006554)1.88043122
139Arterial thrombosis (HP:0004420)1.87236980
140Colitis (HP:0002583)1.87138802
141Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.86781857
142Back pain (HP:0003418)1.85775702
143Congenital, generalized hypertrichosis (HP:0004540)1.85421999
144Proximal amyotrophy (HP:0007126)1.81364618
145Chest pain (HP:0100749)1.79231914
146Hypophosphatemic rickets (HP:0004912)1.75975546
147Abnormality of skeletal muscle fiber size (HP:0012084)1.75788432
148Conjunctival hamartoma (HP:0100780)1.75619037
149Abnormal eating behavior (HP:0100738)1.75566645
150Renal cortical cysts (HP:0000803)1.75475876
151Hypercholesterolemia (HP:0003124)1.75408870
152Granulocytopenia (HP:0001913)1.75036332
153Vertigo (HP:0002321)1.74665198
154Lethargy (HP:0001254)1.73366926
155Goiter (HP:0000853)1.73256254
156Hyperkalemia (HP:0002153)1.72850847
157Optic neuritis (HP:0100653)1.72368710
158Retrobulbar optic neuritis (HP:0100654)1.72368710
159Recurrent fungal infections (HP:0002841)1.71064334
160Muscle stiffness (HP:0003552)1.70598380
161Glomerulopathy (HP:0100820)1.69888118
162Easy fatigability (HP:0003388)1.68885181
163Keratoconjunctivitis sicca (HP:0001097)1.67855888
164Gastrointestinal infarctions (HP:0005244)1.67837812
165Xanthomatosis (HP:0000991)1.67705217
166Recurrent gram-negative bacterial infections (HP:0005420)1.67265788
167Leukocytosis (HP:0001974)1.66174326
168Hypochromic microcytic anemia (HP:0004840)1.63251926
169Tinnitus (HP:0000360)1.61805822
170Microcytic anemia (HP:0001935)1.61776682
171Vasculitis (HP:0002633)1.60829793
172Gastrointestinal dysmotility (HP:0002579)1.60614207
173Dysautonomia (HP:0002459)1.59564192
174Autoimmune hemolytic anemia (HP:0001890)1.59158109
175Gingivitis (HP:0000230)1.58976900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D7.00758457
2RIPK46.26142278
3CAMK1G4.93791049
4TRIB34.73042278
5BCKDK4.64249603
6SIK14.51185095
7INSRR3.07134299
8ERN12.81544007
9PDK42.80042834
10PDK32.80042834
11BTK2.77058472
12RIPK12.62857979
13MST42.31773132
14MST1R2.27395273
15LMTK22.27167008
16FRK2.22214388
17FES2.18857288
18BLK2.15602964
19SYK2.03291327
20GRK62.00449953
21PRKAA22.00185302
22GRK51.88811870
23TNK21.84371157
24EIF2AK11.83199264
25CDK91.79539949
26CSF1R1.68051025
27TAOK31.63921553
28PIK3CG1.63332600
29PDK21.60861236
30HCK1.57456192
31PDGFRA1.34781376
32LATS11.33925067
33FGR1.33490129
34MAP2K11.32304774
35LYN1.29729393
36FGFR31.28075827
37BMPR21.25846323
38PRKD31.20724951
39STK161.20357016
40MAPK121.18688586
41MAP4K11.14100021
42FGFR21.13894737
43EPHB21.13333944
44PIK3CA1.12872653
45MET1.09338497
46PRKAA11.08029401
47PIM21.07961957
48EPHB11.04704433
49MAP3K31.02955223
50IRAK31.01735653
51IRAK41.01435682
52PRPF4B0.99020423
53MATK0.97817568
54ADRBK10.97736856
55MAP3K60.94848730
56IKBKB0.94621122
57KIT0.93582858
58TYK20.93052430
59MAP3K110.92847223
60CDK60.92327890
61PAK10.90667563
62FLT30.88719859
63ITK0.84521688
64MAP2K30.82051693
65ARAF0.81469309
66JAK10.79182472
67TXK0.78042699
68YES10.77886011
69DAPK30.77653427
70DDR20.77451765
71MARK30.77386576
72PDGFRB0.75425481
73CAMKK20.75351199
74PKN20.74394346
75LCK0.73796889
76MAPK40.73212230
77FER0.72423373
78TGFBR20.69985907
79TAOK20.69331208
80SIK30.68740232
81MAPKAPK30.68499706
82PDPK10.67900963
83JAK20.67601006
84TIE10.67207786
85PRKCH0.67001448
86MAP3K50.65738205
87MAP3K10.65710004
88CAMK10.63477474
89IGF1R0.62245882
90JAK30.61950398
91MAPK110.61159851
92MAP3K20.59365849
93ABL20.58143479
94FGFR40.56812029
95PRKACG0.55812086
96PKN10.55127318
97GSK3A0.53079240
98DAPK20.50558392
99RET0.50195547
100MTOR0.50012246
101TBK10.49962976
102PDK10.46857893
103PRKD20.46250400
104PHKG10.45128916
105PHKG20.45128916
106MAPK150.44332819
107IRAK10.44105031
108LRRK20.43790367
109NEK90.43522553
110NLK0.43236374
111LATS20.42678979
112FYN0.41958878
113MYLK0.41834264
114PRKD10.41616367
115EIF2AK20.41486600
116KSR20.41346223
117RAF10.40410044
118PRKG10.40334866
119RPS6KB10.38980919
120PIM10.36969869
121PAK20.35637123
122TRPM70.35618463
123ADRBK20.34919935
124PINK10.34576827
125TAOK10.33886400
126FGFR10.32876402
127CDK40.32807045
128INSR0.32143274
129MARK20.31468831
130HIPK20.30869419
131EPHA30.30601422
132PRKG20.30367352
133IRAK20.28451684
134STK30.28195298
135STK38L0.27552475
136PTK60.27317860
137ILK0.26243405
138AKT10.22629876
139CSK0.21050712
140SRC0.20630443
141TEC0.19908024
142PASK0.19433613
143MAP2K20.18738928
144PTK2B0.17917885
145BMX0.17738129
146MAPK30.14975258
147ABL10.13725695
148PRKCZ0.13084023
149PRKACA0.12829202
150PRKCE0.11927119
151ZAP700.11859948
152MAP2K60.10290158
153STK380.09614936

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.22549072
2Propanoate metabolism_Homo sapiens_hsa006404.78684539
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.22480144
4PPAR signaling pathway_Homo sapiens_hsa033204.09916933
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.91162542
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.78628953
7Platelet activation_Homo sapiens_hsa046113.71528561
8Fatty acid metabolism_Homo sapiens_hsa012123.48605018
9Glycerolipid metabolism_Homo sapiens_hsa005613.28362708
10Fatty acid degradation_Homo sapiens_hsa000712.84066552
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.51190118
12Pyruvate metabolism_Homo sapiens_hsa006202.41791771
13Fat digestion and absorption_Homo sapiens_hsa049752.24591837
14SNARE interactions in vesicular transport_Homo sapiens_hsa041302.09806798
15beta-Alanine metabolism_Homo sapiens_hsa004101.99961824
16AMPK signaling pathway_Homo sapiens_hsa041521.96761275
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.95851937
18Hematopoietic cell lineage_Homo sapiens_hsa046401.82296966
19Caffeine metabolism_Homo sapiens_hsa002321.76900469
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.74282306
21Malaria_Homo sapiens_hsa051441.69676323
22Carbon metabolism_Homo sapiens_hsa012001.63421641
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61852557
24Butanoate metabolism_Homo sapiens_hsa006501.57514815
25Osteoclast differentiation_Homo sapiens_hsa043801.52595108
26Peroxisome_Homo sapiens_hsa041461.49610181
27Chemokine signaling pathway_Homo sapiens_hsa040621.49007428
28Sulfur metabolism_Homo sapiens_hsa009201.48602772
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44801593
30B cell receptor signaling pathway_Homo sapiens_hsa046621.32053121
31Insulin resistance_Homo sapiens_hsa049311.31567830
32Insulin signaling pathway_Homo sapiens_hsa049101.19053347
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18760742
34Fatty acid elongation_Homo sapiens_hsa000621.18110194
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.12842830
36Phenylalanine metabolism_Homo sapiens_hsa003601.11203292
37Protein digestion and absorption_Homo sapiens_hsa049741.04351837
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.02397533
39Glucagon signaling pathway_Homo sapiens_hsa049220.98877490
40Leishmaniasis_Homo sapiens_hsa051400.96095146
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95206498
42Tyrosine metabolism_Homo sapiens_hsa003500.93955008
43Vitamin B6 metabolism_Homo sapiens_hsa007500.93618023
44Type II diabetes mellitus_Homo sapiens_hsa049300.91732861
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.90869276
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90100015
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89078987
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88960721
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87271870
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85302435
51Phagosome_Homo sapiens_hsa041450.85182122
52Tryptophan metabolism_Homo sapiens_hsa003800.83295233
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83207905
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.83023546
55Shigellosis_Homo sapiens_hsa051310.81457696
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80491045
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79816887
58Gap junction_Homo sapiens_hsa045400.79546178
59Pentose phosphate pathway_Homo sapiens_hsa000300.77879009
60Renin secretion_Homo sapiens_hsa049240.77375976
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.74800869
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73126007
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.72941446
64Endocytosis_Homo sapiens_hsa041440.70904477
65Nitrogen metabolism_Homo sapiens_hsa009100.69114096
66Starch and sucrose metabolism_Homo sapiens_hsa005000.65513355
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.63998873
68Collecting duct acid secretion_Homo sapiens_hsa049660.63659120
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62188645
70Staphylococcus aureus infection_Homo sapiens_hsa051500.61948069
71T cell receptor signaling pathway_Homo sapiens_hsa046600.61551540
72Pancreatic secretion_Homo sapiens_hsa049720.61516663
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60833403
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60725929
75Tuberculosis_Homo sapiens_hsa051520.60037719
76Pancreatic cancer_Homo sapiens_hsa052120.59725729
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59440447
78Linoleic acid metabolism_Homo sapiens_hsa005910.58859419
79Non-small cell lung cancer_Homo sapiens_hsa052230.57908175
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56946640
81Serotonergic synapse_Homo sapiens_hsa047260.54940565
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53384394
83ECM-receptor interaction_Homo sapiens_hsa045120.52155138
84Fructose and mannose metabolism_Homo sapiens_hsa000510.50988692
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49554315
86Galactose metabolism_Homo sapiens_hsa000520.49459273
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49048091
88ABC transporters_Homo sapiens_hsa020100.48133022
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48075899
90Primary immunodeficiency_Homo sapiens_hsa053400.47294266
91Alcoholism_Homo sapiens_hsa050340.46876652
92Systemic lupus erythematosus_Homo sapiens_hsa053220.46820614
93Arachidonic acid metabolism_Homo sapiens_hsa005900.45498791
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44753800
95Histidine metabolism_Homo sapiens_hsa003400.44461065
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.44160571
97Graft-versus-host disease_Homo sapiens_hsa053320.41776781
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41192684
99Rap1 signaling pathway_Homo sapiens_hsa040150.40683661
100Morphine addiction_Homo sapiens_hsa050320.37128931
101Choline metabolism in cancer_Homo sapiens_hsa052310.36774347
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36611535
103Sulfur relay system_Homo sapiens_hsa041220.35671756
104Allograft rejection_Homo sapiens_hsa053300.35232468
105VEGF signaling pathway_Homo sapiens_hsa043700.34988084
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34297605
107Chronic myeloid leukemia_Homo sapiens_hsa052200.32799270
108Lysine degradation_Homo sapiens_hsa003100.32745314
109Legionellosis_Homo sapiens_hsa051340.31929125
110Glutathione metabolism_Homo sapiens_hsa004800.31812298
111Biosynthesis of amino acids_Homo sapiens_hsa012300.31667116
112Autoimmune thyroid disease_Homo sapiens_hsa053200.30432948
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29939439
114Salmonella infection_Homo sapiens_hsa051320.29878190
115Measles_Homo sapiens_hsa051620.28769362
116Folate biosynthesis_Homo sapiens_hsa007900.28609226
117Chemical carcinogenesis_Homo sapiens_hsa052040.28141026
118mTOR signaling pathway_Homo sapiens_hsa041500.27309689
119Circadian rhythm_Homo sapiens_hsa047100.27226175
120Thyroid cancer_Homo sapiens_hsa052160.26780891
121Asthma_Homo sapiens_hsa053100.25034861
122Metabolic pathways_Homo sapiens_hsa011000.24741360
123Apoptosis_Homo sapiens_hsa042100.24723804
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24529156
125Acute myeloid leukemia_Homo sapiens_hsa052210.23726781
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23628627
127Focal adhesion_Homo sapiens_hsa045100.23068542
128HIF-1 signaling pathway_Homo sapiens_hsa040660.21208615
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20360334
130Lysosome_Homo sapiens_hsa041420.20265151
131cAMP signaling pathway_Homo sapiens_hsa040240.19060240
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18839402
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17817737
134Thyroid hormone synthesis_Homo sapiens_hsa049180.12620817
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10586842
136FoxO signaling pathway_Homo sapiens_hsa040680.10144055
137Protein export_Homo sapiens_hsa030600.09048363
138Salivary secretion_Homo sapiens_hsa049700.07874245
139Toxoplasmosis_Homo sapiens_hsa051450.07724595
140Renin-angiotensin system_Homo sapiens_hsa046140.07544899
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07494421
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06941752
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06588987
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.06518739
145Melanoma_Homo sapiens_hsa052180.05906935
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05695138
147Ovarian steroidogenesis_Homo sapiens_hsa049130.05183711
148Small cell lung cancer_Homo sapiens_hsa052220.04665291
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03195681
150Retinol metabolism_Homo sapiens_hsa008300.02724837
151Amoebiasis_Homo sapiens_hsa051460.02537603
152Proteoglycans in cancer_Homo sapiens_hsa052050.01979595
153Hepatitis C_Homo sapiens_hsa051600.01079816
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00596476

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