LGALS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)7.71615046
2intestinal epithelial cell development (GO:0060576)7.09018587
3regulation of respiratory burst (GO:0060263)6.99997293
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.47619052
5proline biosynthetic process (GO:0006561)6.43995877
6regulation of cellular extravasation (GO:0002691)6.40342311
7primary alcohol catabolic process (GO:0034310)6.08047274
8calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.06750092
9ATP synthesis coupled proton transport (GO:0015986)5.72960407
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.72960407
11ethanol metabolic process (GO:0006067)5.71033724
12positive regulation of chemokine secretion (GO:0090197)5.58250907
13digestive system process (GO:0022600)5.37958802
14intestinal cholesterol absorption (GO:0030299)5.36518501
15regulation of hydrogen peroxide metabolic process (GO:0010310)5.20124624
16hepatocyte apoptotic process (GO:0097284)5.17512886
17regulation of chemokine secretion (GO:0090196)5.14059999
18membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.13128217
19maintenance of gastrointestinal epithelium (GO:0030277)4.98925565
20positive regulation of digestive system process (GO:0060456)4.93333961
21lung secretory cell differentiation (GO:0061140)4.90851552
22immunoglobulin mediated immune response (GO:0016064)4.86632200
23neutrophil activation involved in immune response (GO:0002283)4.84132984
24sulfation (GO:0051923)4.82344927
25negative regulation of keratinocyte proliferation (GO:0010839)4.79645963
26proline metabolic process (GO:0006560)4.63228527
27membrane repolarization during action potential (GO:0086011)4.62546477
28bile acid and bile salt transport (GO:0015721)4.56103260
29respiratory electron transport chain (GO:0022904)4.51918475
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48917258
31antigen processing and presentation of endogenous antigen (GO:0019883)4.44590587
32electron transport chain (GO:0022900)4.40013120
33bundle of His cell to Purkinje myocyte communication (GO:0086069)4.36610991
34detection of other organism (GO:0098543)4.27261490
35ribosomal small subunit assembly (GO:0000028)4.18821051
36detection of bacterium (GO:0016045)4.18743461
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17980414
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17980414
39positive regulation by organism of defense response of other organism involved in symbiotic interact4.17980414
40modulation by symbiont of host immune response (GO:0052553)4.17980414
41positive regulation by symbiont of host defense response (GO:0052509)4.17980414
42modulation by symbiont of host defense response (GO:0052031)4.17980414
43negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.16670369
44potassium ion export (GO:0071435)4.16055301
45regulation of dendritic cell antigen processing and presentation (GO:0002604)4.15306556
46cell differentiation involved in embryonic placenta development (GO:0060706)4.15236589
47antibacterial humoral response (GO:0019731)4.13299370
48cardiovascular system development (GO:0072358)4.12425686
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.10786779
50antimicrobial humoral response (GO:0019730)4.08616740
51UDP-N-acetylglucosamine metabolic process (GO:0006047)4.08073696
52GDP-mannose metabolic process (GO:0019673)4.08049541
53low-density lipoprotein particle remodeling (GO:0034374)4.06502769
54ventricular cardiac muscle cell action potential (GO:0086005)4.02313071
55ribosomal large subunit biogenesis (GO:0042273)4.01665574
56negative regulation of epidermal cell differentiation (GO:0045605)4.00754097
57glandular epithelial cell differentiation (GO:0002067)4.00441241
58digestion (GO:0007586)3.96564194
59negative regulation of glial cell proliferation (GO:0060253)3.95778259
60viral transcription (GO:0019083)3.90282966
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.86474796
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.84945971
63negative regulation of cell killing (GO:0031342)3.84945971
64regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.83837233
65regulation of vitamin metabolic process (GO:0030656)3.82734750
66positive regulation of gamma-delta T cell activation (GO:0046645)3.82365967
67endocrine pancreas development (GO:0031018)3.80345586
68regulation of bile acid biosynthetic process (GO:0070857)3.79949215
69macrophage activation involved in immune response (GO:0002281)3.78330615
70angiotensin maturation (GO:0002003)3.73428469
71translational termination (GO:0006415)3.72861116
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70202625
73phosphatidylinositol acyl-chain remodeling (GO:0036149)3.69866045
74response to peptidoglycan (GO:0032494)3.69522873
75interferon-gamma-mediated signaling pathway (GO:0060333)3.69431242
76regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.68315168
77atrial cardiac muscle cell action potential (GO:0086014)3.67366271
78flavonoid metabolic process (GO:0009812)3.66621321
79positive regulation of antigen processing and presentation (GO:0002579)3.66247026
80B cell mediated immunity (GO:0019724)3.66045929
81glutamine family amino acid biosynthetic process (GO:0009084)3.64700396
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63244660
83lipoprotein transport (GO:0042953)3.60436733
84phosphatidylserine acyl-chain remodeling (GO:0036150)3.59922297
85detection of external biotic stimulus (GO:0098581)3.56840455
86killing of cells of other organism (GO:0031640)3.56139604
87disruption of cells of other organism (GO:0044364)3.56139604
88peptide catabolic process (GO:0043171)3.55485216
89regulation of antigen processing and presentation (GO:0002577)3.54044475
90NADH metabolic process (GO:0006734)3.48878281
91regulation of keratinocyte proliferation (GO:0010837)3.48691838
92mucosal immune response (GO:0002385)3.45704031
93O-glycan processing (GO:0016266)3.43324942
94epithelial structure maintenance (GO:0010669)3.42030319
953-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.41612605
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.41612605
97regulation of guanylate cyclase activity (GO:0031282)3.40545612
98positive regulation of epidermal cell differentiation (GO:0045606)3.39746857
99positive regulation of mast cell activation (GO:0033005)3.38762717
100ATP biosynthetic process (GO:0006754)3.36805339
101tumor necrosis factor-mediated signaling pathway (GO:0033209)3.29756219
102oxidative phosphorylation (GO:0006119)3.28178033
103defense response to fungus (GO:0050832)3.26242102
104regulation of interferon-beta biosynthetic process (GO:0045357)3.25270330
105organ or tissue specific immune response (GO:0002251)3.25006182
106regulation of heart rate by cardiac conduction (GO:0086091)3.24157242
107detection of molecule of bacterial origin (GO:0032490)3.23940932
108SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23165851
109translational elongation (GO:0006414)3.23064271
110cytidine metabolic process (GO:0046087)3.22837452
111cytidine catabolic process (GO:0006216)3.22837452
112cytidine deamination (GO:0009972)3.22837452
113galactose catabolic process (GO:0019388)3.22334539
114positive regulation of mast cell activation involved in immune response (GO:0033008)3.21997122
115positive regulation of mast cell degranulation (GO:0043306)3.21997122
116diol metabolic process (GO:0034311)3.21549689
117detection of biotic stimulus (GO:0009595)3.20999961
118positive regulation of interleukin-8 secretion (GO:2000484)3.19561291
119microglial cell activation (GO:0001774)3.19308516
120regulation of mast cell degranulation (GO:0043304)3.19181330
121actin filament depolymerization (GO:0030042)3.18726637
122cotranslational protein targeting to membrane (GO:0006613)3.16758189
123protein targeting to ER (GO:0045047)3.16650746
124antigen processing and presentation via MHC class Ib (GO:0002475)3.16235096
125glycolipid catabolic process (GO:0019377)3.15543264
126maturation of SSU-rRNA (GO:0030490)3.14459881
127negative regulation of interleukin-12 production (GO:0032695)3.13213501
128cellular extravasation (GO:0045123)3.12395664
129urea metabolic process (GO:0019627)3.11928760
130urea cycle (GO:0000050)3.11928760
131cellular protein complex disassembly (GO:0043624)3.10704004
132phosphatidylserine metabolic process (GO:0006658)3.10469842
133glycosphingolipid catabolic process (GO:0046479)3.10417737
134cellular response to epinephrine stimulus (GO:0071872)3.10111960
135cardiac conduction (GO:0061337)3.08994152
136positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.05679718
137neutrophil activation (GO:0042119)3.05144267
138vitamin A metabolic process (GO:0006776)3.04128330
139leukotriene metabolic process (GO:0006691)3.03527744
140fat-soluble vitamin biosynthetic process (GO:0042362)3.02842101
141regulation of metalloenzyme activity (GO:0048552)3.00268248
142viral life cycle (GO:0019058)3.00160766
143establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99348657
144glutathione derivative metabolic process (GO:1901685)2.98537790
145glutathione derivative biosynthetic process (GO:1901687)2.98537790
146regulation of triglyceride catabolic process (GO:0010896)2.98069434
147regulation of mast cell activation (GO:0033003)2.96853981
148positive regulation of type 2 immune response (GO:0002830)2.96153137
149cellular response to interferon-gamma (GO:0071346)2.93230176
150myeloid cell activation involved in immune response (GO:0002275)2.93192568
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.92922074
152T-helper 1 type immune response (GO:0042088)2.91680807
153regulation of mast cell activation involved in immune response (GO:0033006)2.91485111
154regulation of T cell tolerance induction (GO:0002664)2.90668066
155granulocyte activation (GO:0036230)2.90043519
156macrophage activation (GO:0042116)2.89125224
157plasma lipoprotein particle assembly (GO:0034377)2.85853764
158regulation of gamma-delta T cell activation (GO:0046643)2.84588168
159neutrophil mediated immunity (GO:0002446)2.82962616
160respiratory burst (GO:0045730)2.81098113
161regulation of B cell receptor signaling pathway (GO:0050855)2.79059536
162T cell costimulation (GO:0031295)2.78981032
163regulation of leukocyte degranulation (GO:0043300)2.76569849
164response to interferon-gamma (GO:0034341)2.75859494
165lymphocyte costimulation (GO:0031294)2.74543813
166regulation of tolerance induction (GO:0002643)2.74315700
167phospholipid efflux (GO:0033700)2.74206659
168positive regulation of leukocyte degranulation (GO:0043302)2.71612583
169response to host immune response (GO:0052572)2.69160315
170response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69160315
171epoxygenase P450 pathway (GO:0019373)2.68284142
172regulation of cholesterol esterification (GO:0010872)2.67088995
173fructose metabolic process (GO:0006000)2.65629061
174dendritic cell chemotaxis (GO:0002407)2.65193473
175very-low-density lipoprotein particle assembly (GO:0034379)2.65020264
176diacylglycerol metabolic process (GO:0046339)2.62162138
177cobalamin metabolic process (GO:0009235)2.60472612
178positive regulation of guanylate cyclase activity (GO:0031284)2.58203733
179oligosaccharide catabolic process (GO:0009313)2.58098715
180ceramide catabolic process (GO:0046514)2.57149646
181protein-lipid complex assembly (GO:0065005)2.57064384
182lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56792151
183cellular response to type I interferon (GO:0071357)2.55655320
184type I interferon signaling pathway (GO:0060337)2.55655320
185positive regulation of cellular amide metabolic process (GO:0034250)2.54784757
186defense response to protozoan (GO:0042832)2.54717784
187response to type I interferon (GO:0034340)2.53860315
188dendritic cell migration (GO:0036336)2.51495015
189positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.51322603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.95992748
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.51325039
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.54876498
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.34534020
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79727059
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.78193916
7* HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.54642446
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48244221
9GATA4_25053715_ChIP-Seq_YYC3_Human3.42573011
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.40920708
11GATA6_25053715_ChIP-Seq_YYC3_Human3.24747013
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96989723
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91100287
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.90686193
15SOX2_20726797_ChIP-Seq_SW620_Human2.90280274
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.88661690
17* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84291598
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64144852
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.59273588
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47450182
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.45742869
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44629173
23AR_21909140_ChIP-Seq_LNCAP_Human2.42881196
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42553374
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.40364423
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38548596
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23275286
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.21319885
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18923759
30VDR_24763502_ChIP-Seq_THP-1_Human2.16690231
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12745469
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09367557
33* SPI1_23547873_ChIP-Seq_NB4_Human2.06357145
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05972685
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92778453
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.91861634
37VDR_21846776_ChIP-Seq_THP-1_Human1.91579868
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84014373
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.80395399
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78933962
41SPI1_23127762_ChIP-Seq_K562_Human1.77629189
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77168541
43E2F7_22180533_ChIP-Seq_HELA_Human1.76296935
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74194803
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71344974
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71303994
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69833694
48RUNX_20019798_ChIP-Seq_JUKART_Human1.69536252
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65390009
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65101798
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.64253981
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63465649
53VDR_24787735_ChIP-Seq_THP-1_Human1.61778543
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.60470360
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.60385126
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59899695
57* STAT1_20625510_ChIP-Seq_HELA_Human1.58133070
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55748441
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53264229
60SCL_19346495_ChIP-Seq_HPC-7_Human1.51513407
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51326940
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46046466
63MYB_26560356_Chip-Seq_TH2_Human1.44371605
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42693312
65NANOG_20526341_ChIP-Seq_ESCs_Human1.41811179
66ATF3_27146783_Chip-Seq_COLON_Human1.39799930
67MAF_26560356_Chip-Seq_TH1_Human1.39783425
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.38481948
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38067462
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.35692961
71KLF5_25053715_ChIP-Seq_YYC3_Human1.35364546
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35167512
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35033493
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33628492
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.33185518
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32428762
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32028235
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31940563
79* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30396625
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30053314
81EZH2_22144423_ChIP-Seq_EOC_Human1.28551361
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28082187
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27953680
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27226372
85UTX_26944678_Chip-Seq_JUKART_Human1.26498439
86MYB_26560356_Chip-Seq_TH1_Human1.26059236
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25534158
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25280307
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24122100
90* BCL6_27268052_Chip-Seq_Bcells_Human1.23210868
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23027607
92RACK7_27058665_Chip-Seq_MCF-7_Human1.22741027
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21432416
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18815336
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17846869
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16990561
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16920144
98PHF8_20622854_ChIP-Seq_HELA_Human1.16287862
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15646114
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15039495
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14849837
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11910281
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11481067
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.11453613
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11290903
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11144214
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08050005
108GATA3_27048872_Chip-Seq_THYMUS_Human1.07418504
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05946920
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04949326
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04191656
112GATA1_22025678_ChIP-Seq_K562_Human1.04158620
113MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03839379
114GATA3_24758297_ChIP-Seq_MCF-7_Human1.03616594
115* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03369427
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03231758
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03137461
118TCF7_22412390_ChIP-Seq_EML_Mouse1.02916070
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.02598709
120ELF5_23300383_ChIP-Seq_T47D_Human1.02361907
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01121788
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00623800
123HNF4A_19822575_ChIP-Seq_HepG2_Human1.00510542
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98913984
125LXR_22292898_ChIP-Seq_THP-1_Human0.98768863
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98584111
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98519649
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98501386
129GATA3_26560356_Chip-Seq_TH2_Human0.98231886
130EGR1_19032775_ChIP-ChIP_M12_Human0.98141816
131GATA1_19941826_ChIP-Seq_K562_Human0.97717149
132GATA2_19941826_ChIP-Seq_K562_Human0.95439129
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94421042
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.93666231
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.93574692
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92653686
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.92650751
138ZNF263_19887448_ChIP-Seq_K562_Human0.92468469
139* XRN2_22483619_ChIP-Seq_HELA_Human0.92233310
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91146490
141BCOR_27268052_Chip-Seq_Bcells_Human0.90180244
142SA1_27219007_Chip-Seq_Bcells_Human0.89964667
143* CTCF_20526341_ChIP-Seq_ESCs_Human0.89870493
144MAF_26560356_Chip-Seq_TH2_Human0.89051981
145SMAD_19615063_ChIP-ChIP_OVARY_Human0.88435548
146PU_27001747_Chip-Seq_BMDM_Mouse0.87010385
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86875964
148P300_27268052_Chip-Seq_Bcells_Human0.86747302
149CTCF_27219007_Chip-Seq_Bcells_Human0.85978839
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.85462860
151* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85007257
152KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84883363
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83935415
154SA1_27219007_Chip-Seq_ERYTHROID_Human0.83321383
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82960722
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82960722
157* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82787871
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.82724153
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82317409
160MYC_19829295_ChIP-Seq_ESCs_Human0.81437301
161E2F1_20622854_ChIP-Seq_HELA_Human0.79911165
162NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79452780
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.78521806
164NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78264731
165DCP1A_22483619_ChIP-Seq_HELA_Human0.78225996
166JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.77646435
167GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77411621
168SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77036008
169GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76626567
170UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75771409
171IRF8_22096565_ChIP-ChIP_GC-B_Human0.75738359
172E2F1_18555785_ChIP-Seq_MESCs_Mouse0.74849168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH7.04453868
2MP0005360_urolithiasis5.90735939
3MP0001873_stomach_inflammation4.79654063
4MP0001666_abnormal_nutrient_absorption4.40564453
5MP0000462_abnormal_digestive_system4.10063848
6MP0001835_abnormal_antigen_presentation3.72368415
7MP0009379_abnormal_foot_pigmentation3.71207502
8MP0000490_abnormal_crypts_of3.66833920
9MP0004264_abnormal_extraembryonic_tissu3.63279191
10MP0010155_abnormal_intestine_physiology3.35896787
11MP0001663_abnormal_digestive_system3.24683064
12MP0010234_abnormal_vibrissa_follicle2.99834900
13MP0003436_decreased_susceptibility_to2.98116925
14MP0003123_paternal_imprinting2.90715411
15MP0003866_abnormal_defecation2.89522468
16MP0005381_digestive/alimentary_phenotyp2.85520820
17MP0001664_abnormal_digestion2.85032430
18MP0002139_abnormal_hepatobiliary_system2.80119120
19MP0003303_peritoneal_inflammation2.75461583
20MP0005085_abnormal_gallbladder_physiolo2.71857806
21MP0006082_CNS_inflammation2.65874780
22MP0009785_altered_susceptibility_to2.58467230
23MP0000537_abnormal_urethra_morphology2.50678134
24MP0003300_gastrointestinal_ulcer2.49098447
25MP0005025_abnormal_response_to2.38326103
26MP0005671_abnormal_response_to2.37000237
27MP0000477_abnormal_intestine_morphology2.32141624
28MP0002419_abnormal_innate_immunity2.30813969
29MP0001800_abnormal_humoral_immune2.24890712
30MP0001790_abnormal_immune_system2.24300281
31MP0005387_immune_system_phenotype2.24300281
32MP0005000_abnormal_immune_tolerance2.14870964
33MP0003806_abnormal_nucleotide_metabolis2.13988380
34MP0000685_abnormal_immune_system2.11284350
35MP0004019_abnormal_vitamin_homeostasis2.02998701
36MP0002452_abnormal_antigen_presenting1.99057539
37MP0003868_abnormal_feces_composition1.95219993
38MP0002723_abnormal_immune_serum1.93338423
39MP0003252_abnormal_bile_duct1.93203188
40MP0005058_abnormal_lysosome_morphology1.88959443
41MP0003787_abnormal_imprinting1.88910493
42MP0002277_abnormal_respiratory_mucosa1.82185260
43MP0008875_abnormal_xenobiotic_pharmacok1.81760591
44MP0001819_abnormal_immune_cell1.74683580
45MP0002420_abnormal_adaptive_immunity1.73479059
46MP0001485_abnormal_pinna_reflex1.72304179
47MP0003693_abnormal_embryo_hatching1.71260414
48MP0000470_abnormal_stomach_morphology1.70824616
49MP0009764_decreased_sensitivity_to1.67122042
50MP0010352_gastrointestinal_tract_polyps1.61321622
51MP0005464_abnormal_platelet_physiology1.59044850
52MP0001533_abnormal_skeleton_physiology1.58952836
53MP0008469_abnormal_protein_level1.58919971
54MP0008872_abnormal_physiological_respon1.58740894
55MP0005365_abnormal_bile_salt1.54127949
56MP0003075_altered_response_to1.37721924
57MP0009333_abnormal_splenocyte_physiolog1.37048528
58MP0002166_altered_tumor_susceptibility1.33211961
59MP0003172_abnormal_lysosome_physiology1.31247933
60MP0005165_increased_susceptibility_to1.31226787
61MP0010329_abnormal_lipoprotein_level1.30448655
62MP0000716_abnormal_immune_system1.25165342
63MP0008260_abnormal_autophagy1.21892152
64MP0009840_abnormal_foam_cell1.21286652
65MP0003183_abnormal_peptide_metabolism1.20311913
66MP0002405_respiratory_system_inflammati1.13020613
67MP0002822_catalepsy1.12507217
68MP0002796_impaired_skin_barrier1.11585606
69MP0009643_abnormal_urine_homeostasis1.10041678
70MP0002998_abnormal_bone_remodeling1.09356689
71MP0000858_altered_metastatic_potential1.08946937
72MP0000566_synostosis1.07413821
73MP0000538_abnormal_urinary_bladder1.05569770
74MP0005084_abnormal_gallbladder_morpholo1.04883923
75MP0004147_increased_porphyrin_level1.03503084
76MP0002398_abnormal_bone_marrow1.03193806
77MP0000613_abnormal_salivary_gland1.02991227
78MP0005409_darkened_coat_color1.01179915
79MP0001849_ear_inflammation0.97426408
80MP0000604_amyloidosis0.96016607
81MP0003315_abnormal_perineum_morphology0.95740264
82MP0004957_abnormal_blastocyst_morpholog0.95735745
83MP0002138_abnormal_hepatobiliary_system0.95589574
84MP0002429_abnormal_blood_cell0.94695568
85MP0003763_abnormal_thymus_physiology0.94477654
86MP0002132_abnormal_respiratory_system0.92611898
87MP0005332_abnormal_amino_acid0.92127848
88MP0002006_tumorigenesis0.91552964
89MP0000343_altered_response_to0.90768124
90MP0005310_abnormal_salivary_gland0.88957910
91MP0000678_abnormal_parathyroid_gland0.88705452
92MP0000689_abnormal_spleen_morphology0.87947931
93MP0005448_abnormal_energy_balance0.87782915
94MP0003724_increased_susceptibility_to0.86512413
95MP0005666_abnormal_adipose_tissue0.85512712
96MP0009763_increased_sensitivity_to0.83415536
97MP0002722_abnormal_immune_system0.83096186
98MP0003705_abnormal_hypodermis_morpholog0.82609579
99MP0006054_spinal_hemorrhage0.81433927
100MP0010386_abnormal_urinary_bladder0.80543013
101MP0002098_abnormal_vibrissa_morphology0.80307317
102MP0001986_abnormal_taste_sensitivity0.80226787
103MP0000249_abnormal_blood_vessel0.78962403
104MP0003448_altered_tumor_morphology0.78879511
105MP0004510_myositis0.74594369
106MP0004883_abnormal_blood_vessel0.74151137
107MP0005166_decreased_susceptibility_to0.72456919
108MP0005535_abnormal_body_temperature0.72311479
109MP0002089_abnormal_postnatal_growth/wei0.72171834
110MP0003283_abnormal_digestive_organ0.72168380
111MP0004484_altered_response_of0.70951682
112MP0009642_abnormal_blood_homeostasis0.68593830
113MP0009697_abnormal_copulation0.67649252
114MP0003453_abnormal_keratinocyte_physiol0.66801344
115MP0001845_abnormal_inflammatory_respons0.62864004
116MP0001764_abnormal_homeostasis0.62118017
117MP0005083_abnormal_biliary_tract0.61565494
118MP0005501_abnormal_skin_physiology0.61483251
119MP0010030_abnormal_orbit_morphology0.61096286
120MP0005451_abnormal_body_composition0.61005630
121MP0003718_maternal_effect0.59270251
122MP0003878_abnormal_ear_physiology0.59019767
123MP0005377_hearing/vestibular/ear_phenot0.59019767
124MP0003191_abnormal_cellular_cholesterol0.56732075
125MP0003879_abnormal_hair_cell0.54339244
126MP0001216_abnormal_epidermal_layer0.54147132
127MP0003828_pulmonary_edema0.53796439
128MP0001765_abnormal_ion_homeostasis0.52643709
129MP0005319_abnormal_enzyme/_coenzyme0.52584181
130MP0002118_abnormal_lipid_homeostasis0.52570554
131MP0005636_abnormal_mineral_homeostasis0.51162567
132MP0004947_skin_inflammation0.51110322
133MP0000467_abnormal_esophagus_morphology0.50107638
134MP0002163_abnormal_gland_morphology0.48875346
135MP0004782_abnormal_surfactant_physiolog0.48624166
136MP0006036_abnormal_mitochondrial_physio0.48624063
137MP0003119_abnormal_digestive_system0.48176216
138MP0000609_abnormal_liver_physiology0.47576214
139MP0010678_abnormal_skin_adnexa0.47543111
140MP0002136_abnormal_kidney_physiology0.45815491
141MP0005220_abnormal_exocrine_pancreas0.45621162
142MP0000465_gastrointestinal_hemorrhage0.45437979
143MP0005584_abnormal_enzyme/coenzyme_acti0.45047214
144MP0009384_cardiac_valve_regurgitation0.44893909
145MP0002254_reproductive_system_inflammat0.44256191
146MP0001191_abnormal_skin_condition0.43577927
147MP0001756_abnormal_urination0.43454957
148MP0002148_abnormal_hypersensitivity_rea0.42166076
149MP0002693_abnormal_pancreas_physiology0.42136179
150MP0004185_abnormal_adipocyte_glucose0.41460579

Predicted human phenotypes

RankGene SetZ-score
1Ventricular fibrillation (HP:0001663)8.25121282
2Ileus (HP:0002595)6.78788586
3Congenital sensorineural hearing impairment (HP:0008527)6.21123561
4Eczematoid dermatitis (HP:0000976)5.35259640
5Abnormality of macrophages (HP:0004311)4.71024585
6Recurrent bacterial skin infections (HP:0005406)4.45569760
7Recurrent abscess formation (HP:0002722)4.40382910
8Increased hepatocellular lipid droplets (HP:0006565)4.21406809
9Lipid accumulation in hepatocytes (HP:0006561)4.20808587
10Systemic lupus erythematosus (HP:0002725)4.20399121
11Posterior subcapsular cataract (HP:0007787)4.14442720
12Increased intramyocellular lipid droplets (HP:0012240)4.04003316
13Micronodular cirrhosis (HP:0001413)4.03730090
14Abnormality of the vitamin B12 metabolism (HP:0004341)4.02730135
15Hepatic necrosis (HP:0002605)3.98225711
16Increased muscle lipid content (HP:0009058)3.96510579
17Hepatocellular necrosis (HP:0001404)3.94911206
18Mitochondrial inheritance (HP:0001427)3.91396245
19Right ventricular cardiomyopathy (HP:0011663)3.83352632
20Amyloidosis (HP:0011034)3.79130399
21Abnormality of vitamin B metabolism (HP:0004340)3.77570542
22Syncope (HP:0001279)3.77128764
23Abnormal hemoglobin (HP:0011902)3.75770472
24Recurrent gram-negative bacterial infections (HP:0005420)3.75496029
25Myositis (HP:0100614)3.75465195
26Glycosuria (HP:0003076)3.74205760
27Abnormality of urine glucose concentration (HP:0011016)3.74205760
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.72025616
29Elevated erythrocyte sedimentation rate (HP:0003565)3.64087334
30Obstructive lung disease (HP:0006536)3.62715524
31Chronic obstructive pulmonary disease (HP:0006510)3.62715524
32Orchitis (HP:0100796)3.61974686
33Abdominal distention (HP:0003270)3.57706257
34Prolonged QT interval (HP:0001657)3.44574567
35Increased CSF lactate (HP:0002490)3.41078879
36Chronic diarrhea (HP:0002028)3.40016303
37Rectal prolapse (HP:0002035)3.36507952
38Acute encephalopathy (HP:0006846)3.32510480
39Chorioretinal atrophy (HP:0000533)3.30554731
40Abnormality of cells of the erythroid lineage (HP:0012130)3.29675252
41Late onset (HP:0003584)3.27936517
42Retrobulbar optic neuritis (HP:0100654)3.21628126
43Optic neuritis (HP:0100653)3.21628126
44Gastrointestinal infarctions (HP:0005244)3.21467753
45Vasculitis (HP:0002633)3.21327423
46Abnormal mitochondria in muscle tissue (HP:0008316)3.20898402
47Petechiae (HP:0000967)3.18922218
48Hypercortisolism (HP:0001578)3.18322171
49Hydroxyprolinuria (HP:0003080)3.18040505
50Abnormality of proline metabolism (HP:0010907)3.18040505
51Abnormal number of erythroid precursors (HP:0012131)3.15720396
52Renal Fanconi syndrome (HP:0001994)3.15516054
53Stomatitis (HP:0010280)3.13173098
54Abnormal EKG (HP:0003115)3.09214667
55Acute necrotizing encephalopathy (HP:0006965)3.08945583
56Hemoptysis (HP:0002105)3.08817189
57Steatorrhea (HP:0002570)3.07935666
58Abnormality of vitamin metabolism (HP:0100508)3.06257635
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03785626
60Meningitis (HP:0001287)3.03606085
61Mediastinal lymphadenopathy (HP:0100721)3.02272772
62Recurrent skin infections (HP:0001581)3.01570148
63Thin bony cortex (HP:0002753)3.01420775
64Malnutrition (HP:0004395)2.99450631
65Hyperphosphaturia (HP:0003109)2.96598221
66Macrocytic anemia (HP:0001972)2.91967636
67Recurrent fungal infections (HP:0002841)2.91367764
68Exertional dyspnea (HP:0002875)2.89367015
69Pulmonary infiltrates (HP:0002113)2.87975101
70Gingivitis (HP:0000230)2.87935303
71Pustule (HP:0200039)2.86386927
72Abnormal biliary tract morphology (HP:0012440)2.85687214
73Ventricular arrhythmia (HP:0004308)2.84252581
74Ketoacidosis (HP:0001993)2.80132302
75Urticaria (HP:0001025)2.78767752
76Increased serum lactate (HP:0002151)2.76940865
77Hypobetalipoproteinemia (HP:0003563)2.75296183
78Abnormality of the pleura (HP:0002103)2.74734424
79Ankyloglossia (HP:0010296)2.71641282
80Encephalitis (HP:0002383)2.68031784
81Pancreatitis (HP:0001733)2.67614115
82Biliary tract neoplasm (HP:0100574)2.64998950
83Progressive macrocephaly (HP:0004481)2.64838870
84Abnormality of liposaccharide metabolism (HP:0010968)2.64830279
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.64830279
86Abnormality of glycolipid metabolism (HP:0010969)2.64830279
87Widely patent fontanelles and sutures (HP:0004492)2.64462088
88Colon cancer (HP:0003003)2.58701375
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58216228
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58216228
91Hyperammonemia (HP:0001987)2.56293443
92Lethargy (HP:0001254)2.54517352
93Chronic mucocutaneous candidiasis (HP:0002728)2.52700544
94Recurrent cutaneous fungal infections (HP:0011370)2.52700544
95Neoplasm of the rectum (HP:0100743)2.52318432
96Gingival bleeding (HP:0000225)2.52109201
97Conjunctival hamartoma (HP:0100780)2.50150402
98Abnormality of small intestinal villus morphology (HP:0011472)2.49849471
99Villous atrophy (HP:0011473)2.49849471
100Chest pain (HP:0100749)2.48431489
101Woolly hair (HP:0002224)2.48337259
102Spontaneous hematomas (HP:0007420)2.48187891
103Trismus (HP:0000211)2.45988068
104Abnormal urine phosphate concentration (HP:0012599)2.45434936
105Esophageal varix (HP:0002040)2.45292282
106Conjugated hyperbilirubinemia (HP:0002908)2.43065391
107Palpitations (HP:0001962)2.40603877
108Abnormal delayed hypersensitivity skin test (HP:0002963)2.40248749
109Cerebral edema (HP:0002181)2.40012768
110Subcapsular cataract (HP:0000523)2.39773544
111Purpura (HP:0000979)2.39383214
112Wide cranial sutures (HP:0010537)2.38758027
113Glomerulonephritis (HP:0000099)2.38444049
114Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38373934
115Respiratory failure (HP:0002878)2.36755458
116Increased cerebral lipofuscin (HP:0011813)2.36553102
117Reticulocytopenia (HP:0001896)2.35900763
118Abnormality of complement system (HP:0005339)2.35703869
119Neoplasm of the small intestine (HP:0100833)2.33966061
120Lactic acidosis (HP:0003128)2.33106265
121Abnormality of placental membranes (HP:0011409)2.32074348
122Amniotic constriction ring (HP:0009775)2.32074348
123Symptomatic seizures (HP:0011145)2.30191189
124Gangrene (HP:0100758)2.29463854
125Vacuolated lymphocytes (HP:0001922)2.28669697
126Skin rash (HP:0000988)2.28451161
127Bone cyst (HP:0012062)2.28135075
128Premature loss of primary teeth (HP:0006323)2.27559102
129Loss of speech (HP:0002371)2.26585184
130Cheilitis (HP:0100825)2.26450936
131Epistaxis (HP:0000421)2.26051385
132Dysostosis multiplex (HP:0000943)2.25971811
133Delayed epiphyseal ossification (HP:0002663)2.25216548
134Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25123576
135Keratoconjunctivitis sicca (HP:0001097)2.24980938
136Abnormality of renal resorption (HP:0011038)2.24487394
137CNS demyelination (HP:0007305)2.22450982
138Hemorrhage of the eye (HP:0011885)2.21440683
139Hyperparathyroidism (HP:0000843)2.21427805
140Pulmonary embolism (HP:0002204)2.19220294
141Gastrointestinal dysmotility (HP:0002579)2.18657454
142Inflammation of the large intestine (HP:0002037)2.17939056
143Intrahepatic cholestasis (HP:0001406)2.17527509
144Abnormality of the gastric mucosa (HP:0004295)2.16199708
145Nausea (HP:0002018)2.15749575
146Abnormality of glycolysis (HP:0004366)2.14714486
147Increased serum pyruvate (HP:0003542)2.14714486
148Colitis (HP:0002583)2.14577318
149Acanthocytosis (HP:0001927)2.14436423
150Hypophosphatemia (HP:0002148)2.12313902
151Increased serum ferritin (HP:0003281)2.11565258
152Respiratory difficulties (HP:0002880)2.08972209
153Exercise intolerance (HP:0003546)2.08841953
154Keratoconjunctivitis (HP:0001096)2.07191777
155Anorexia (HP:0002039)2.06918672
156Xanthomatosis (HP:0000991)2.06806975
157Fat malabsorption (HP:0002630)2.04559930
158Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04184680
159Emotional lability (HP:0000712)2.03634853
160Osteomyelitis (HP:0002754)2.03435267
161Proximal tubulopathy (HP:0000114)2.03044243
162Increased neuronal autofluorescent lipopigment (HP:0002074)2.02780361
163Gastrointestinal inflammation (HP:0004386)2.02364489
164Enlarged epiphyses (HP:0010580)2.02253249
165Fragile skin (HP:0001030)2.00951467
166Abnormality of iron homeostasis (HP:0011031)2.00579713
167Neoplasm of the colon (HP:0100273)2.00237351
168Prolonged bleeding time (HP:0003010)1.99292915
169Cellulitis (HP:0100658)1.96089156
170Nephritis (HP:0000123)1.94525030
171Paresthesia (HP:0003401)1.94389444
172Recurrent viral infections (HP:0004429)1.93255732
173Polyneuropathy (HP:0001271)1.91818699
174Episodic fever (HP:0001954)1.91723622
175Increased IgM level (HP:0003496)1.88016838
176Restrictive lung disease (HP:0002091)1.87842207
177Recurrent pneumonia (HP:0006532)1.87546258
178Increased IgE level (HP:0003212)1.87322216
179Arterial thrombosis (HP:0004420)1.87115485
180Glomerulopathy (HP:0100820)1.87022975
181Autoimmune thrombocytopenia (HP:0001973)1.85426876
182Pigmentary retinal degeneration (HP:0001146)1.84883765
183Leukocytosis (HP:0001974)1.83987224
184Joint swelling (HP:0001386)1.83150429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.55171902
2NME15.68281541
3FRK5.38874330
4RIPK44.24647999
5MAP2K23.47686357
6ACVR1B3.46951727
7MAP2K63.22484326
8MST1R3.16323816
9PBK3.03669955
10TYK22.99643292
11MST42.92699816
12PRKG22.84022621
13NUAK12.51955347
14BMPR22.51012841
15CSK2.29001825
16RPS6KB22.22487892
17IRAK42.08481139
18TLK12.08336505
19ZAP702.02479388
20STK391.94723114
21NME21.93769634
22FES1.84993433
23MAP3K141.81699615
24CSF1R1.75639931
25PRPF4B1.71397022
26JAK31.69648127
27MAP3K111.64762713
28MAP2K31.60207268
29SYK1.59590438
30KIT1.57106072
31PDK21.56587901
32PTK61.56252699
33BLK1.52981391
34FGR1.52941247
35BTK1.52010437
36EIF2AK11.48312043
37IKBKE1.47644764
38EPHB21.43422151
39TXK1.41348251
40LYN1.39556927
41TTK1.39008984
42MAP3K21.32435591
43MAP3K131.31942624
44JAK11.29179689
45IKBKB1.28126985
46PDPK11.24227250
47GRK61.23845216
48ERN11.17519180
49CAMK2B1.16117313
50TNK21.14869090
51JAK21.14549684
52CAMK2D1.14188014
53HCK1.13600399
54TESK21.11991409
55TESK11.10960182
56PIK3CA1.10942085
57WNK41.09261073
58FGFR41.07177140
59AURKB1.06025617
60PKN21.05708135
61CAMK2G1.01063249
62MAP2K11.01022389
63PDK11.00768184
64LCK1.00208050
65EPHB10.99344752
66NEK20.98247106
67ERBB20.95533408
68BUB10.93192935
69ITK0.93070198
70MET0.91165797
71TGFBR20.86921825
72MYLK0.86492983
73TAOK30.86192281
74CDK190.85492305
75EPHA20.85337778
76PAK40.83999793
77PTK20.81774835
78OXSR10.81667753
79GRK70.81646329
80MAP3K80.78049860
81MAP3K100.76169185
82MAP3K120.74601871
83MAP3K30.73418897
84FGFR30.73099301
85TEC0.71185197
86TAOK10.70389073
87ERBB40.69112139
88CDC42BPA0.68181187
89MAPK70.68017185
90TAOK20.67692073
91RIPK10.66778164
92IRAK10.65391029
93PIM20.65023535
94VRK10.62568887
95NLK0.62346726
96YES10.62280723
97PRKCI0.62118575
98PAK10.57622062
99FYN0.57416884
100IRAK20.56457652
101PIM10.55424964
102GRK10.55223756
103MAPK110.53513349
104SIK30.52842358
105EEF2K0.50674335
106SCYL20.50668155
107NEK10.50540038
108BCKDK0.50061783
109KSR20.48881624
110EPHA30.48679977
111DAPK20.48577641
112IRAK30.46070659
113MARK30.45638226
114LATS10.45336884
115MAPK120.44397346
116LRRK20.41617208
117PRKACG0.39332303
118MAP3K10.38640278
119TBK10.38396161
120PRKCQ0.35763970
121PRKCA0.35711577
122CSNK1A10.35097827
123MAPK150.34360083
124BCR0.33568179
125CDK60.33561113
126ABL10.33143311
127PDK40.31857765
128PDK30.31857765
129ILK0.31052152
130PLK10.30530212
131ABL20.29894660
132MAP4K10.29068253
133CHUK0.28714865
134RPS6KC10.27545530
135RPS6KL10.27545530
136DDR20.26992479
137PRKCZ0.26800176
138CAMK10.24653119
139STK240.24175490
140TRIB30.22848869
141FER0.22791818
142CSNK1E0.22546770
143CDK70.22143988
144STK100.20968766
145PRKAA20.20919803
146STK38L0.20803138
147CAMKK10.20402567
148PIK3CG0.19294776
149SRC0.19118461
150AURKA0.18322021
151MATK0.18234895
152PRKCD0.18230744
153ROCK10.18043937
154CAMK2A0.17929756
155PASK0.17536255
156MELK0.16145170
157DYRK1B0.15930171
158LIMK10.15718476

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.36272462
2Asthma_Homo sapiens_hsa053103.98937072
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.68169140
4Allograft rejection_Homo sapiens_hsa053303.48665232
5Graft-versus-host disease_Homo sapiens_hsa053323.37261221
6Staphylococcus aureus infection_Homo sapiens_hsa051503.30693169
7Autoimmune thyroid disease_Homo sapiens_hsa053203.25078842
8Maturity onset diabetes of the young_Homo sapiens_hsa049503.15230942
9Oxidative phosphorylation_Homo sapiens_hsa001903.05387363
10Parkinsons disease_Homo sapiens_hsa050122.72815525
11Type I diabetes mellitus_Homo sapiens_hsa049402.72298519
12Leishmaniasis_Homo sapiens_hsa051402.67261653
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51441964
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.50909602
15Ribosome_Homo sapiens_hsa030102.50211514
16Histidine metabolism_Homo sapiens_hsa003402.49291486
17Sulfur metabolism_Homo sapiens_hsa009202.49198000
18Nitrogen metabolism_Homo sapiens_hsa009102.35361259
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30036466
20Alzheimers disease_Homo sapiens_hsa050102.06606589
21Glutathione metabolism_Homo sapiens_hsa004802.06318859
22Mineral absorption_Homo sapiens_hsa049782.01311731
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99861206
24Fructose and mannose metabolism_Homo sapiens_hsa000511.98502461
25Antigen processing and presentation_Homo sapiens_hsa046121.94651746
26Viral myocarditis_Homo sapiens_hsa054161.93579436
27Arginine and proline metabolism_Homo sapiens_hsa003301.88563029
28Linoleic acid metabolism_Homo sapiens_hsa005911.87957942
29Fatty acid degradation_Homo sapiens_hsa000711.86996924
30Pyruvate metabolism_Homo sapiens_hsa006201.85777652
31Tryptophan metabolism_Homo sapiens_hsa003801.85454481
32Huntingtons disease_Homo sapiens_hsa050161.82577054
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82007142
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.78926292
35Vitamin digestion and absorption_Homo sapiens_hsa049771.72383453
36Folate biosynthesis_Homo sapiens_hsa007901.71673033
37Tuberculosis_Homo sapiens_hsa051521.68460444
38Rheumatoid arthritis_Homo sapiens_hsa053231.66520033
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57395621
40Pentose phosphate pathway_Homo sapiens_hsa000301.57025639
41Arachidonic acid metabolism_Homo sapiens_hsa005901.56538886
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56223898
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54790931
44Galactose metabolism_Homo sapiens_hsa000521.48887126
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.47145423
46Osteoclast differentiation_Homo sapiens_hsa043801.45302185
47Other glycan degradation_Homo sapiens_hsa005111.44959611
48Renin-angiotensin system_Homo sapiens_hsa046141.43715915
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42035454
50Protein digestion and absorption_Homo sapiens_hsa049741.39841415
51Hematopoietic cell lineage_Homo sapiens_hsa046401.38086950
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35831827
53Toxoplasmosis_Homo sapiens_hsa051451.33343524
54Glycerolipid metabolism_Homo sapiens_hsa005611.28531493
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24963564
56Carbon metabolism_Homo sapiens_hsa012001.21600015
57Arginine biosynthesis_Homo sapiens_hsa002201.18427939
58Cardiac muscle contraction_Homo sapiens_hsa042601.18157951
59beta-Alanine metabolism_Homo sapiens_hsa004101.18068590
60Bile secretion_Homo sapiens_hsa049761.17098553
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15291562
62Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13442199
63Pancreatic secretion_Homo sapiens_hsa049721.12822290
64Phagosome_Homo sapiens_hsa041451.10022486
65Starch and sucrose metabolism_Homo sapiens_hsa005001.00119199
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98856466
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98405491
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.97000393
69Gastric acid secretion_Homo sapiens_hsa049710.90093283
70B cell receptor signaling pathway_Homo sapiens_hsa046620.89573394
71Tight junction_Homo sapiens_hsa045300.88984003
72Chemical carcinogenesis_Homo sapiens_hsa052040.88758425
73Ether lipid metabolism_Homo sapiens_hsa005650.88614208
74Herpes simplex infection_Homo sapiens_hsa051680.87517016
75Chemokine signaling pathway_Homo sapiens_hsa040620.86055362
76PPAR signaling pathway_Homo sapiens_hsa033200.84767324
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84222458
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.81607071
79African trypanosomiasis_Homo sapiens_hsa051430.80198477
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79444836
81Retinol metabolism_Homo sapiens_hsa008300.78123514
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77602543
83Vibrio cholerae infection_Homo sapiens_hsa051100.75574742
84Legionellosis_Homo sapiens_hsa051340.75481873
85Hepatitis C_Homo sapiens_hsa051600.74041088
86Lysosome_Homo sapiens_hsa041420.71787658
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71100306
88Propanoate metabolism_Homo sapiens_hsa006400.69710576
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68420969
90Primary immunodeficiency_Homo sapiens_hsa053400.67636051
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66583810
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65050910
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64314467
94Metabolic pathways_Homo sapiens_hsa011000.64173932
95Biosynthesis of amino acids_Homo sapiens_hsa012300.61173112
96TNF signaling pathway_Homo sapiens_hsa046680.60688409
97Malaria_Homo sapiens_hsa051440.60438146
98Butanoate metabolism_Homo sapiens_hsa006500.60119482
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.60070322
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.59150546
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55703986
102Selenocompound metabolism_Homo sapiens_hsa004500.53848857
103Sulfur relay system_Homo sapiens_hsa041220.51436206
104Thyroid hormone synthesis_Homo sapiens_hsa049180.50139110
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.49869491
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.49681531
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48063942
108Complement and coagulation cascades_Homo sapiens_hsa046100.47371196
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47330096
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44853906
111Sphingolipid metabolism_Homo sapiens_hsa006000.43456337
112Bladder cancer_Homo sapiens_hsa052190.43420070
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42402668
114Measles_Homo sapiens_hsa051620.42285550
115Caffeine metabolism_Homo sapiens_hsa002320.40378312
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.40022855
117Proteasome_Homo sapiens_hsa030500.38459747
118Platelet activation_Homo sapiens_hsa046110.38011588
119T cell receptor signaling pathway_Homo sapiens_hsa046600.37493051
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.35746823
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35574766
122Peroxisome_Homo sapiens_hsa041460.34151591
123Systemic lupus erythematosus_Homo sapiens_hsa053220.33198811
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32393711
125Lysine degradation_Homo sapiens_hsa003100.31945952
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31768846
127Fatty acid elongation_Homo sapiens_hsa000620.31671999
128Protein export_Homo sapiens_hsa030600.30842388
129Pertussis_Homo sapiens_hsa051330.30538464
130Shigellosis_Homo sapiens_hsa051310.29829462
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.29810447
132Pyrimidine metabolism_Homo sapiens_hsa002400.29033057
133Mismatch repair_Homo sapiens_hsa034300.28950928
134Acute myeloid leukemia_Homo sapiens_hsa052210.27250036
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25856593
136ABC transporters_Homo sapiens_hsa020100.24458649
137Salmonella infection_Homo sapiens_hsa051320.23942300
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21939305
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19999017
140Fatty acid metabolism_Homo sapiens_hsa012120.19520576
141Insulin secretion_Homo sapiens_hsa049110.18803822
142Thyroid cancer_Homo sapiens_hsa052160.18231700
143Amoebiasis_Homo sapiens_hsa051460.17950668
144N-Glycan biosynthesis_Homo sapiens_hsa005100.15680341
145Influenza A_Homo sapiens_hsa051640.15295516
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13508041
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13430444
148Homologous recombination_Homo sapiens_hsa034400.11811342
149DNA replication_Homo sapiens_hsa030300.10266992

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