LGALS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.66341072
2UDP-N-acetylglucosamine metabolic process (GO:0006047)7.89025269
3bundle of His cell to Purkinje myocyte communication (GO:0086069)7.34258444
4maintenance of gastrointestinal epithelium (GO:0030277)7.24502141
5intestinal epithelial cell development (GO:0060576)6.59355918
6regulation of guanylate cyclase activity (GO:0031282)6.46484975
7intestinal cholesterol absorption (GO:0030299)6.21913246
8glucuronate metabolic process (GO:0019585)5.95103067
9uronic acid metabolic process (GO:0006063)5.95103067
10actin filament depolymerization (GO:0030042)5.56179720
11positive regulation of respiratory burst (GO:0060267)5.47977136
12epithelial structure maintenance (GO:0010669)5.47576164
13epoxygenase P450 pathway (GO:0019373)5.44251256
14flavonoid metabolic process (GO:0009812)5.37207057
15O-glycan processing (GO:0016266)5.34871336
16digestive system process (GO:0022600)5.20290486
173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.16485601
18purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.16485601
19fat-soluble vitamin biosynthetic process (GO:0042362)4.98066959
20hepatocyte apoptotic process (GO:0097284)4.93015255
21angiotensin maturation (GO:0002003)4.89957649
22regulation of respiratory burst (GO:0060263)4.70884990
23sulfation (GO:0051923)4.68265311
24renal system process involved in regulation of blood volume (GO:0001977)4.67075665
25vitamin A metabolic process (GO:0006776)4.66634504
26bile acid and bile salt transport (GO:0015721)4.66391526
27endocrine process (GO:0050886)4.66282698
28regulation of systemic arterial blood pressure by hormone (GO:0001990)4.66282698
29regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.66282698
30positive regulation of guanylate cyclase activity (GO:0031284)4.56175790
31calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.53933344
32hemidesmosome assembly (GO:0031581)4.50184708
33urea cycle (GO:0000050)4.46377232
34urea metabolic process (GO:0019627)4.43312937
35ethanol oxidation (GO:0006069)4.42761022
36nucleotide-sugar biosynthetic process (GO:0009226)4.38319249
37drug metabolic process (GO:0017144)4.37593553
38sulfate transmembrane transport (GO:1902358)4.35771825
39glomerular filtration (GO:0003094)4.28568751
40hormone catabolic process (GO:0042447)4.28127315
41ventricular cardiac muscle cell action potential (GO:0086005)4.18908943
42regulation of systemic arterial blood pressure (GO:0003073)4.17942498
43regulation of bile acid biosynthetic process (GO:0070857)4.14344592
44lipoprotein transport (GO:0042953)4.07575635
45nitrogen cycle metabolic process (GO:0071941)4.06891827
46antibacterial humoral response (GO:0019731)4.03970418
47desmosome organization (GO:0002934)4.03689592
48antimicrobial humoral response (GO:0019730)4.01603499
49regulation of pseudopodium assembly (GO:0031272)4.01387222
50nucleotide-sugar metabolic process (GO:0009225)4.00803768
51regulation of chemokine secretion (GO:0090196)3.99016420
52regulation of cholesterol homeostasis (GO:2000188)3.93772447
53drug catabolic process (GO:0042737)3.92752212
54regulation of cGMP biosynthetic process (GO:0030826)3.92103480
55renal filtration (GO:0097205)3.91693075
56transcytosis (GO:0045056)3.90517138
57membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.90064389
58diacylglycerol metabolic process (GO:0046339)3.80150613
59oligosaccharide biosynthetic process (GO:0009312)3.78314135
60ethanol metabolic process (GO:0006067)3.76842453
61sperm capacitation (GO:0048240)3.67593909
62regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.66992995
63positive regulation of fatty acid beta-oxidation (GO:0032000)3.65735895
64galactose catabolic process (GO:0019388)3.64150967
65very-low-density lipoprotein particle assembly (GO:0034379)3.63671786
66cell differentiation involved in embryonic placenta development (GO:0060706)3.63122832
67bicarbonate transport (GO:0015701)3.63091370
68GDP-mannose metabolic process (GO:0019673)3.61635882
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61565439
70primary alcohol catabolic process (GO:0034310)3.61150671
71sulfur amino acid catabolic process (GO:0000098)3.60352741
72fructose metabolic process (GO:0006000)3.57656303
73sulfate transport (GO:0008272)3.56197035
74arginine metabolic process (GO:0006525)3.53856696
75lung secretory cell differentiation (GO:0061140)3.53351682
76alkaloid metabolic process (GO:0009820)3.52733980
77cellular response to hepatocyte growth factor stimulus (GO:0035729)3.51490235
78response to hepatocyte growth factor (GO:0035728)3.51490235
79renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.49371650
80negative regulation of keratinocyte proliferation (GO:0010839)3.48382126
81protein autoprocessing (GO:0016540)3.45880816
82membrane repolarization during action potential (GO:0086011)3.44863555
83bile acid metabolic process (GO:0008206)3.44186625
84digestion (GO:0007586)3.43850326
85positive regulation of lipid catabolic process (GO:0050996)3.43382150
86drug transmembrane transport (GO:0006855)3.42860285
87sulfur compound transport (GO:0072348)3.41382570
88regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.39284657
89positive regulation of epidermal cell differentiation (GO:0045606)3.37728195
90thyroid hormone metabolic process (GO:0042403)3.37244886
91regulation of hydrogen peroxide metabolic process (GO:0010310)3.35159837
92diol metabolic process (GO:0034311)3.34391037
93complement activation, classical pathway (GO:0006958)3.33968584
94drug transport (GO:0015893)3.33960780
95protein O-linked glycosylation (GO:0006493)3.33781083
96regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.32537312
97phenylpropanoid metabolic process (GO:0009698)3.29535912
98positive regulation of glycoprotein biosynthetic process (GO:0010560)3.29455746
99cGMP-mediated signaling (GO:0019934)3.25812808
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23343416
101glucocorticoid biosynthetic process (GO:0006704)3.22177315
102nucleoside diphosphate biosynthetic process (GO:0009133)3.20540866
103adhesion of symbiont to host cell (GO:0044650)3.20440653
104virion attachment to host cell (GO:0019062)3.20440653
105regulation of heart rate by cardiac conduction (GO:0086091)3.20250202
106regulation of cGMP metabolic process (GO:0030823)3.20002590
107regulation of cellular extravasation (GO:0002691)3.17194907
108tight junction assembly (GO:0070830)3.16254491
109mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13608544
110glucose 6-phosphate metabolic process (GO:0051156)3.12193658
111transepithelial transport (GO:0070633)3.10696617
112cardiac conduction (GO:0061337)3.10317335
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10098154
114glycosphingolipid catabolic process (GO:0046479)3.09890180
115positive regulation of Cdc42 GTPase activity (GO:0043089)3.09047326
116positive regulation of glycoprotein metabolic process (GO:1903020)3.08379739
117regulation of actin nucleation (GO:0051125)3.07900686
118auditory receptor cell differentiation (GO:0042491)3.06133950
119regulation of vitamin metabolic process (GO:0030656)3.05221311
120glycolipid catabolic process (GO:0019377)3.04574460
121NADH metabolic process (GO:0006734)3.04208923
122regulation of viral release from host cell (GO:1902186)3.04074343
123phospholipid efflux (GO:0033700)3.03005603
124cell communication involved in cardiac conduction (GO:0086065)3.01341551
125homocysteine metabolic process (GO:0050667)2.99535190
126fucose catabolic process (GO:0019317)2.96788543
127L-fucose metabolic process (GO:0042354)2.96788543
128L-fucose catabolic process (GO:0042355)2.96788543
129cellular glucuronidation (GO:0052695)2.95398123
130phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.94940096
131glandular epithelial cell differentiation (GO:0002067)2.94498727
132keratinocyte proliferation (GO:0043616)2.93597599
133vitamin transmembrane transport (GO:0035461)2.93417714
134receptor guanylyl cyclase signaling pathway (GO:0007168)2.93327557
135peptide catabolic process (GO:0043171)2.92299911
136antigen processing and presentation of endogenous antigen (GO:0019883)2.91780867
137glutamine family amino acid biosynthetic process (GO:0009084)2.90306212
138peptide hormone processing (GO:0016486)2.89189798
139thrombin receptor signaling pathway (GO:0070493)2.87145574
140sodium ion homeostasis (GO:0055078)2.86752718
141pyrimidine-containing compound transmembrane transport (GO:0072531)2.86277255
142eosinophil chemotaxis (GO:0048245)2.84666110
143protein-lipid complex assembly (GO:0065005)2.84509159
144modified amino acid transport (GO:0072337)2.84157958
145striated muscle atrophy (GO:0014891)2.83407261
146positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.78956526
147regulation of triglyceride catabolic process (GO:0010896)2.78720894
148positive regulation of pseudopodium assembly (GO:0031274)2.78590701
149cytidine catabolic process (GO:0006216)2.78402813
150cytidine deamination (GO:0009972)2.78402813
151cytidine metabolic process (GO:0046087)2.78402813
152lipoprotein metabolic process (GO:0042157)2.77208234
153phospholipid scrambling (GO:0017121)2.76601628
154exogenous drug catabolic process (GO:0042738)2.75835004
155positive regulation of actin filament depolymerization (GO:0030836)2.75378449
156plasma lipoprotein particle assembly (GO:0034377)2.75291809
157energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73892818
158ATP synthesis coupled proton transport (GO:0015986)2.73892818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.40213393
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.89578904
3SOX2_27498859_Chip-Seq_STOMACH_Mouse4.42842346
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.45458926
5* GATA4_25053715_ChIP-Seq_YYC3_Human3.43714972
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.42535733
7GATA6_25053715_ChIP-Seq_YYC3_Human3.32644387
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.20838347
9* SOX2_20726797_ChIP-Seq_SW620_Human3.15088555
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79372822
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77910129
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.60175513
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51868149
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.50751147
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28613909
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.17683601
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.16530583
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.13062275
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.11451487
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.08912217
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.02641563
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.00219527
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.99501183
24KLF5_25053715_ChIP-Seq_YYC3_Human1.95040623
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92969009
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92541598
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.87373055
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.86999727
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.86834047
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85480627
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81300683
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80267956
33AR_21909140_ChIP-Seq_LNCAP_Human1.78739925
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.78571926
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73096631
36RACK7_27058665_Chip-Seq_MCF-7_Human1.72808113
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.72415942
38ZNF263_19887448_ChIP-Seq_K562_Human1.65177836
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63662964
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.62597335
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62429306
42ATF3_27146783_Chip-Seq_COLON_Human1.61219326
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.58649611
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.56693312
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.54814820
46* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54549991
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54262017
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51489377
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46891180
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46891180
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46596064
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34753376
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29573906
54* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28441402
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24297916
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22063107
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21280511
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21244831
59* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18426538
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14705626
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.14209887
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13249766
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.12025749
64DROSHA_22980978_ChIP-Seq_HELA_Human1.11775300
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11372466
66SA1_27219007_Chip-Seq_Bcells_Human1.09058123
67CEBPB_22108803_ChIP-Seq_LS180_Human1.08644842
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08482029
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08309606
70BCL6_27268052_Chip-Seq_Bcells_Human1.06508234
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06076908
72GATA2_19941826_ChIP-Seq_K562_Human1.05950078
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04978245
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04197301
75CLOCK_20551151_ChIP-Seq_293T_Human1.03967217
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02941478
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02390543
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01600323
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.01432554
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01214063
81CREB1_26743006_Chip-Seq_LNCaP_Human1.01192498
82ELF5_23300383_ChIP-Seq_T47D_Human1.00309612
83BCOR_27268052_Chip-Seq_Bcells_Human0.99626029
84FOXA2_19822575_ChIP-Seq_HepG2_Human0.98330379
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95832926
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95285768
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95071391
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94988591
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93257150
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92716284
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92562457
92GATA1_19941826_ChIP-Seq_K562_Human0.92379889
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92242700
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91804877
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91450011
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91086058
97CTCF_27219007_Chip-Seq_Bcells_Human0.90211018
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88071410
99STAT1_20625510_ChIP-Seq_HELA_Human0.87091452
100BCAT_22108803_ChIP-Seq_LS180_Human0.86098797
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85940031
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85156299
103TP63_22573176_ChIP-Seq_HFKS_Human0.84961246
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84678583
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82906203
106PHF8_20622854_ChIP-Seq_HELA_Human0.82309017
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.82296312
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82207714
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82037149
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81908106
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81200144
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81131543
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80817791
114IRF8_21731497_ChIP-ChIP_J774_Mouse0.80691770
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80476055
116EGR1_19032775_ChIP-ChIP_M12_Human0.79672731
117CDX2_22108803_ChIP-Seq_LS180_Human0.79086232
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79079314
119VDR_24763502_ChIP-Seq_THP-1_Human0.78566228
120E2F1_20622854_ChIP-Seq_HELA_Human0.78442089
121LXR_22292898_ChIP-Seq_THP-1_Human0.76605497
122* NANOG_20526341_ChIP-Seq_ESCs_Human0.75581738
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74581557
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73723984
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72733035
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72569122
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71970499
128* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70044437
129NANOG_18692474_ChIP-Seq_MEFs_Mouse0.69118996
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68803824
131JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.68134573
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67852892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.97649351
2MP0005360_urolithiasis5.01129741
3MP0004264_abnormal_extraembryonic_tissu4.50814881
4MP0001666_abnormal_nutrient_absorption4.34864004
5MP0000462_abnormal_digestive_system4.09283050
6MP0003866_abnormal_defecation3.98991245
7MP0001873_stomach_inflammation3.36393751
8MP0010155_abnormal_intestine_physiology3.15328109
9MP0001663_abnormal_digestive_system3.14360105
10MP0005085_abnormal_gallbladder_physiolo3.06885091
11MP0000537_abnormal_urethra_morphology3.04090638
12MP0005381_digestive/alimentary_phenotyp2.91749255
13MP0000490_abnormal_crypts_of2.86794816
14MP0008004_abnormal_stomach_pH2.64824681
15MP0002822_catalepsy2.59071850
16MP0001664_abnormal_digestion2.43988580
17MP0000477_abnormal_intestine_morphology2.37627399
18MP0010352_gastrointestinal_tract_polyps2.37355508
19MP0009379_abnormal_foot_pigmentation2.34688608
20MP0002139_abnormal_hepatobiliary_system2.33624568
21MP0003300_gastrointestinal_ulcer2.31365047
22MP0008875_abnormal_xenobiotic_pharmacok2.22895402
23MP0006054_spinal_hemorrhage2.17378178
24MP0003252_abnormal_bile_duct2.04140878
25MP0005365_abnormal_bile_salt1.95566482
26MP0003705_abnormal_hypodermis_morpholog1.89138696
27MP0005377_hearing/vestibular/ear_phenot1.78986432
28MP0003878_abnormal_ear_physiology1.78986432
29MP0005409_darkened_coat_color1.74419301
30MP0003283_abnormal_digestive_organ1.72500918
31MP0000538_abnormal_urinary_bladder1.69658449
32MP0005167_abnormal_blood-brain_barrier1.67440748
33MP0009840_abnormal_foam_cell1.60781853
34MP0010329_abnormal_lipoprotein_level1.54762465
35MP0002796_impaired_skin_barrier1.54252486
36MP0001849_ear_inflammation1.50596056
37MP0005670_abnormal_white_adipose1.46051743
38MP0004019_abnormal_vitamin_homeostasis1.45484148
39MP0003806_abnormal_nucleotide_metabolis1.45209683
40MP0010678_abnormal_skin_adnexa1.44217275
41MP0004147_increased_porphyrin_level1.42604208
42MP0001765_abnormal_ion_homeostasis1.32569296
43MP0001764_abnormal_homeostasis1.30077017
44MP0000470_abnormal_stomach_morphology1.27916326
45MP0004043_abnormal_pH_regulation1.27617973
46MP0003868_abnormal_feces_composition1.23009326
47MP0009643_abnormal_urine_homeostasis1.21741891
48MP0003453_abnormal_keratinocyte_physiol1.20881756
49MP0002277_abnormal_respiratory_mucosa1.20366491
50MP0004858_abnormal_nervous_system1.18497544
51MP0008872_abnormal_physiological_respon1.16372821
52MP0003183_abnormal_peptide_metabolism1.12790040
53MP0003879_abnormal_hair_cell1.11684551
54MP0003315_abnormal_perineum_morphology1.09932092
55MP0003724_increased_susceptibility_to1.08829728
56MP0002098_abnormal_vibrissa_morphology1.07406554
57MP0004947_skin_inflammation1.06369393
58MP0009384_cardiac_valve_regurgitation1.05779143
59MP0000467_abnormal_esophagus_morphology1.05531865
60MP0005501_abnormal_skin_physiology1.04469335
61MP0005636_abnormal_mineral_homeostasis1.03832852
62MP0003693_abnormal_embryo_hatching1.02819106
63MP0005166_decreased_susceptibility_to1.00868227
64MP0001188_hyperpigmentation1.00048542
65MP0003303_peritoneal_inflammation0.92849493
66MP0003191_abnormal_cellular_cholesterol0.92847735
67MP0002166_altered_tumor_susceptibility0.92702718
68MP0001216_abnormal_epidermal_layer0.91591415
69MP0000230_abnormal_systemic_arterial0.88633806
70MP0002060_abnormal_skin_morphology0.84994629
71MP0005584_abnormal_enzyme/coenzyme_acti0.82348546
72MP0000613_abnormal_salivary_gland0.81772620
73MP0002971_abnormal_brown_adipose0.81343625
74MP0005025_abnormal_response_to0.78581766
75MP0004484_altered_response_of0.77628895
76MP0000609_abnormal_liver_physiology0.76235693
77MP0005084_abnormal_gallbladder_morpholo0.73402987
78MP0005310_abnormal_salivary_gland0.73395642
79MP0002876_abnormal_thyroid_physiology0.73310680
80MP0005367_renal/urinary_system_phenotyp0.73237659
81MP0000516_abnormal_urinary_system0.73237659
82MP0005332_abnormal_amino_acid0.72326771
83MP0009053_abnormal_anal_canal0.71282237
84MP0006082_CNS_inflammation0.70568073
85MP0005187_abnormal_penis_morphology0.70109641
86MP0001501_abnormal_sleep_pattern0.68640253
87MP0002132_abnormal_respiratory_system0.68026842
88MP0002009_preneoplasia0.67743942
89MP0002136_abnormal_kidney_physiology0.67273502
90MP0003941_abnormal_skin_development0.66700672
91MP0005666_abnormal_adipose_tissue0.66411423
92MP0005448_abnormal_energy_balance0.66376218
93MP0000465_gastrointestinal_hemorrhage0.66212548
94MP0003436_decreased_susceptibility_to0.66013608
95MP0005058_abnormal_lysosome_morphology0.65738854
96MP0008469_abnormal_protein_level0.65688077
97MP0002006_tumorigenesis0.65476325
98MP0009642_abnormal_blood_homeostasis0.65382391
99MP0005319_abnormal_enzyme/_coenzyme0.65324403
100MP0002118_abnormal_lipid_homeostasis0.64870949
101MP0001790_abnormal_immune_system0.64653425
102MP0005387_immune_system_phenotype0.64653425
103MP0002896_abnormal_bone_mineralization0.63950428
104MP0003329_amyloid_beta_deposits0.63833194
105MP0009115_abnormal_fat_cell0.62834563
106MP0002254_reproductive_system_inflammat0.62733003
107MP0000566_synostosis0.60740835
108MP0000678_abnormal_parathyroid_gland0.60426148
109MP0004782_abnormal_surfactant_physiolog0.59592496
110MP0002089_abnormal_postnatal_growth/wei0.59544622
111MP0010771_integument_phenotype0.59276201
112MP0009333_abnormal_splenocyte_physiolog0.59163698
113MP0005535_abnormal_body_temperature0.58964650
114MP0001485_abnormal_pinna_reflex0.58415269
115MP0005451_abnormal_body_composition0.58000634
116MP0000249_abnormal_blood_vessel0.57857914
117MP0001845_abnormal_inflammatory_respons0.57616842
118MP0000604_amyloidosis0.57508339
119MP0001756_abnormal_urination0.56601557
120MP0005165_increased_susceptibility_to0.54901622
121MP0001835_abnormal_antigen_presentation0.52662780
122MP0002138_abnormal_hepatobiliary_system0.52403674
123MP0001533_abnormal_skeleton_physiology0.50458505
124MP0000377_abnormal_hair_follicle0.50255919
125MP0003119_abnormal_digestive_system0.47498678
126MP0009785_altered_susceptibility_to0.45745296
127MP0008873_increased_physiological_sensi0.43634626
128MP0002234_abnormal_pharynx_morphology0.43385913
129MP0004957_abnormal_blastocyst_morpholog0.43357262
130MP0001191_abnormal_skin_condition0.42622350
131MP0000383_abnormal_hair_follicle0.41420448
132MP0003718_maternal_effect0.41418435
133MP0004185_abnormal_adipocyte_glucose0.41294772

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.75614439
2Right ventricular cardiomyopathy (HP:0011663)7.07326545
3Ventricular fibrillation (HP:0001663)4.77780599
4Abdominal distention (HP:0003270)4.44503971
5Malnutrition (HP:0004395)4.40983978
6Systemic lupus erythematosus (HP:0002725)4.31371466
7Hyperactive renin-angiotensin system (HP:0000841)4.05842658
8Conjugated hyperbilirubinemia (HP:0002908)3.89699338
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.86794139
10Flat acetabular roof (HP:0003180)3.82426221
11Congenital sensorineural hearing impairment (HP:0008527)3.79175866
12Pustule (HP:0200039)3.78023230
13Hemorrhage of the eye (HP:0011885)3.65438204
14Micronodular cirrhosis (HP:0001413)3.59300711
15Abnormality of chloride homeostasis (HP:0011422)3.50033137
16Metabolic alkalosis (HP:0200114)3.48956755
17Hyperaldosteronism (HP:0000859)3.42832861
18Gastrointestinal dysmotility (HP:0002579)3.42595800
19Villous atrophy (HP:0011473)3.42389705
20Abnormality of small intestinal villus morphology (HP:0011472)3.42389705
21Rectal prolapse (HP:0002035)3.37856689
22Palpitations (HP:0001962)3.36486032
23Milia (HP:0001056)3.33322136
24Onycholysis (HP:0001806)3.31268287
25Abnormal biliary tract morphology (HP:0012440)3.31046674
26Abnormality of the 1st metacarpal (HP:0010009)3.29734365
27Syncope (HP:0001279)3.27415309
28Fragile nails (HP:0001808)3.19569808
29Chronic diarrhea (HP:0002028)3.18410957
30Woolly hair (HP:0002224)3.17195000
31Biliary tract neoplasm (HP:0100574)3.09109409
32Abnormal tarsal ossification (HP:0008369)3.07294797
33Pili torti (HP:0003777)2.99157595
34Atrophic scars (HP:0001075)2.86358780
35Acanthocytosis (HP:0001927)2.84752465
36Intrahepatic cholestasis (HP:0001406)2.84554974
37Hypokalemia (HP:0002900)2.81921160
38Fat malabsorption (HP:0002630)2.80751392
39Hypobetalipoproteinemia (HP:0003563)2.80455106
40Dehydration (HP:0001944)2.79449283
41Xanthomatosis (HP:0000991)2.78620639
42Cupped ribs (HP:0000887)2.76935629
43Complement deficiency (HP:0004431)2.74897742
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.74839126
45Abnormality of complement system (HP:0005339)2.74118976
46Mildly elevated creatine phosphokinase (HP:0008180)2.73648713
47Abnormality of proline metabolism (HP:0010907)2.71321565
48Hydroxyprolinuria (HP:0003080)2.71321565
49Confusion (HP:0001289)2.71190403
50Hyponatremia (HP:0002902)2.69408160
51Abnormality of the gastric mucosa (HP:0004295)2.69107735
52Glomerulonephritis (HP:0000099)2.68168506
53Plantar hyperkeratosis (HP:0007556)2.62651705
54Ventricular arrhythmia (HP:0004308)2.57261998
55Abnormality of potassium homeostasis (HP:0011042)2.55733344
56Late onset (HP:0003584)2.54675490
57Abnormality of the vitamin B12 metabolism (HP:0004341)2.53414654
58Eczematoid dermatitis (HP:0000976)2.49694819
59Hyperglycinuria (HP:0003108)2.48540441
60Ureteral stenosis (HP:0000071)2.46060894
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42344479
62Abnormality of renin-angiotensin system (HP:0000847)2.42337399
63Fragile skin (HP:0001030)2.40853509
64Neoplasm of the rectum (HP:0100743)2.39367575
65Thin bony cortex (HP:0002753)2.38747483
66Ventricular tachycardia (HP:0004756)2.35668801
67Proximal tubulopathy (HP:0000114)2.35660839
68Abnormality of carpal bone ossification (HP:0006257)2.35329110
69Microretrognathia (HP:0000308)2.35003456
70Abnormality of vitamin B metabolism (HP:0004340)2.34013293
71Abnormality of pyrimidine metabolism (HP:0004353)2.33358678
72Abnormal foot bone ossification (HP:0010675)2.31887922
73Nephritis (HP:0000123)2.31257241
74Nausea (HP:0002018)2.30507274
75Glycosuria (HP:0003076)2.30338026
76Abnormality of urine glucose concentration (HP:0011016)2.30338026
77Wide cranial sutures (HP:0010537)2.29540305
78Neoplasm of the small intestine (HP:0100833)2.28604919
79Abnormality of serine family amino acid metabolism (HP:0010894)2.28137609
80Abnormality of glycine metabolism (HP:0010895)2.28137609
81Hypotension (HP:0002615)2.26922387
82Autoimmune thrombocytopenia (HP:0001973)2.26048699
83Steatorrhea (HP:0002570)2.25763857
84Ureteral obstruction (HP:0006000)2.23949166
85Decreased circulating renin level (HP:0003351)2.21840345
86Uterine neoplasm (HP:0010784)2.21161884
87Cheilitis (HP:0100825)2.20286801
88Nephrolithiasis (HP:0000787)2.19489959
89Esophageal varix (HP:0002040)2.19151956
90Curly hair (HP:0002212)2.18845674
91Renal tubular acidosis (HP:0001947)2.17208658
92Neonatal short-limb short stature (HP:0008921)2.15381844
93Progressive sensorineural hearing impairment (HP:0000408)2.14641359
94Short phalanx of the thumb (HP:0009660)2.14550302
95Symphalangism affecting the phalanges of the hand (HP:0009773)2.13938530
96Posterior subcapsular cataract (HP:0007787)2.13906983
97Cerebral palsy (HP:0100021)2.11670783
98Hypophosphatemia (HP:0002148)2.10768167
99Increased purine levels (HP:0004368)2.09988558
100Hyperuricemia (HP:0002149)2.09988558
101Hyperammonemia (HP:0001987)2.08578445
102Visceral angiomatosis (HP:0100761)2.08440357
103Symptomatic seizures (HP:0011145)2.06727424
104Widely patent fontanelles and sutures (HP:0004492)2.06567602
105Hyperparathyroidism (HP:0000843)2.06105086
106Prolonged QT interval (HP:0001657)2.05660107
107Abnormality of vitamin metabolism (HP:0100508)2.04926433
108Abnormal cartilage morphology (HP:0002763)2.03689296
109Abnormality of nucleobase metabolism (HP:0010932)2.03192986
110Pancreatitis (HP:0001733)2.02628153
111Goiter (HP:0000853)2.02459576
112Autoimmune hemolytic anemia (HP:0001890)2.01181064
113Metabolic acidosis (HP:0001942)2.00895307
114Flattened epiphyses (HP:0003071)2.00323064
115Abnormality of sodium homeostasis (HP:0010931)1.98207449
116Protuberant abdomen (HP:0001538)1.98145649
117Alkalosis (HP:0001948)1.93750543
118Hoarse voice (HP:0001609)1.92934580
119Abnormal hair laboratory examination (HP:0003328)1.92812007
120Glomerulosclerosis (HP:0000096)1.90754709
121Adrenal overactivity (HP:0002717)1.90721862
122Hypoplasia of dental enamel (HP:0006297)1.90093341
123Hyperkalemia (HP:0002153)1.90065590
124Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89783808
125Short 1st metacarpal (HP:0010034)1.89783808
126Abnormality of purine metabolism (HP:0004352)1.89367043
127Hypoglycemic coma (HP:0001325)1.88990310
128Hyperphosphatemia (HP:0002905)1.88363449
129Petechiae (HP:0000967)1.87973587
130Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87593378
131Increased muscle lipid content (HP:0009058)1.87548730
132Growth hormone excess (HP:0000845)1.87240038
133Focal segmental glomerulosclerosis (HP:0000097)1.86768051
134Progressive hearing impairment (HP:0001730)1.86628248
135Ankyloglossia (HP:0010296)1.85161943
136Potter facies (HP:0002009)1.84161488
137Facial shape deformation (HP:0011334)1.84161488
138Flat capital femoral epiphysis (HP:0003370)1.82980516
139Dicarboxylic aciduria (HP:0003215)1.80469449
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80469449
141Hemangiomatosis (HP:0007461)1.80310280
142Bone pain (HP:0002653)1.80200757
143Enlarged epiphyses (HP:0010580)1.79876258
144Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78468272
145Vertebral hypoplasia (HP:0008417)1.78468272
146Pigmentary retinal degeneration (HP:0001146)1.77397561
147Periodontitis (HP:0000704)1.76563525
148Hypolipoproteinemia (HP:0010981)1.75235578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.44462641
2ACVR1B5.92736428
3MST1R5.33340635
4FRK5.22372721
5MST44.40632037
6MAP2K23.51938936
7PRKG23.45141064
8NME13.05940292
9PIK3CA2.52124533
10TESK12.38671194
11EPHA22.33182536
12RIPK12.18550871
13EPHB22.15809683
14MYLK2.13502874
15PTK61.98495818
16MAP3K21.96657845
17MET1.92234305
18FGFR41.75712653
19NUAK11.63565666
20MAP2K61.61644308
21GRK61.58770028
22STK241.36139765
23MAP2K11.32215126
24PBK1.29693753
25MAP3K101.25822574
26TYK21.21391177
27KSR21.21269237
28PRPF4B1.19529468
29PAK41.18059908
30PKN21.16700514
31EPHA31.16556803
32PTK21.06898102
33ERBB21.06244187
34LIMK11.01272821
35PRKCI1.00677227
36TAOK31.00523474
37ERN10.98905641
38MAP4K10.98611747
39FER0.97425537
40TTK0.96608244
41TAOK10.93920812
42STK390.92340423
43SIK10.88543626
44CAMK2D0.86713915
45MAP3K80.85529474
46MAP3K120.83856326
47DDR20.82989680
48FGFR30.79698602
49STK100.76644920
50PRKAA20.74828330
51MATK0.74722044
52AURKB0.74242821
53MAP3K110.73724661
54TNIK0.72874378
55RPS6KB20.72400563
56ERBB40.70131827
57EEF2K0.68829046
58MAP3K10.66674060
59LATS10.66596503
60ABL20.64887021
61DMPK0.63119716
62IRAK10.62872681
63MAPK110.62398330
64CAMK2G0.61389808
65MAP3K30.59914849
66MAP3K70.58995357
67CAMK2B0.58871725
68EPHA40.58789264
69LRRK20.56752352
70NLK0.53007575
71GRK10.52691678
72WNK40.51728811
73PAK10.49998880
74EPHB10.48939848
75TESK20.48846285
76SMG10.46299881
77DYRK1B0.44696124
78PAK30.44678402
79BMX0.44604076
80SCYL20.43145213
81PRKAA10.42862808
82NEK10.41244876
83PIM20.41201300
84IRAK40.39367308
85ZAP700.39142876
86OXSR10.38043242
87TRIB30.37056735
88TBK10.36598932
89RIPK40.35847522
90PDK30.35448547
91PDK40.35448547
92RET0.34982468
93PDGFRA0.33198673
94PDPK10.32982831
95PRKCA0.32557670
96ROCK10.31961910
97PRKCZ0.31710669
98ICK0.31550021
99IKBKE0.31367163
100CDK190.31317746
101JAK10.30996962
102FYN0.29291747
103SRC0.29243342
104JAK20.29150962
105PIK3CG0.28232989
106STK38L0.27687912
107MAP3K90.26903460
108CASK0.25786693
109MAP3K140.25736924
110CSK0.25495836
111TTN0.24975660
112YES10.24901143
113PAK20.24828239
114PDK20.24250394
115BMPR20.23608099
116CSF1R0.23438409
117CSNK1A10.23147244
118CDK60.23008042
119PRKCD0.22904919
120ARAF0.20706796
121IGF1R0.20487184
122MAPKAPK20.19972143
123LYN0.19764470
124STK30.19425497
125PRKACG0.18789414
126RPS6KA20.18029208
127PRKCQ0.17818497
128NME20.16266273
129MELK0.16039810
130AKT20.15972068
131IRAK30.15305834
132MAPKAPK30.15286807
133PDK10.14530454
134BLK0.14399464
135CDC42BPA0.14023209
136AKT30.12902141
137KIT0.08010291
138IRAK20.07453598

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.89356983
2Fat digestion and absorption_Homo sapiens_hsa049753.90368674
3Mineral absorption_Homo sapiens_hsa049783.89495781
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.49292044
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.86481624
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78333588
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.73443642
8Histidine metabolism_Homo sapiens_hsa003402.30257082
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.29566252
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.26760133
11Fructose and mannose metabolism_Homo sapiens_hsa000512.23844293
12Renin-angiotensin system_Homo sapiens_hsa046142.14457889
13Bile secretion_Homo sapiens_hsa049762.14041227
14Galactose metabolism_Homo sapiens_hsa000522.02418168
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92404124
16Vitamin digestion and absorption_Homo sapiens_hsa049771.80000484
17Tryptophan metabolism_Homo sapiens_hsa003801.72605345
18Fatty acid degradation_Homo sapiens_hsa000711.64204998
19Folate biosynthesis_Homo sapiens_hsa007901.64156228
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63977270
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63400179
22Glutathione metabolism_Homo sapiens_hsa004801.58779903
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58595139
24Caffeine metabolism_Homo sapiens_hsa002321.57121026
25Starch and sucrose metabolism_Homo sapiens_hsa005001.54485880
26Protein digestion and absorption_Homo sapiens_hsa049741.53202883
27Nitrogen metabolism_Homo sapiens_hsa009101.52479795
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39301248
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31067956
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25998296
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24268791
32Tight junction_Homo sapiens_hsa045301.24010615
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.20638761
34Glycerolipid metabolism_Homo sapiens_hsa005611.18154431
35Pancreatic secretion_Homo sapiens_hsa049721.17221882
36Pentose phosphate pathway_Homo sapiens_hsa000301.15955824
37Arginine and proline metabolism_Homo sapiens_hsa003301.13897696
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13314891
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09815518
40Pyruvate metabolism_Homo sapiens_hsa006201.08908133
41Carbon metabolism_Homo sapiens_hsa012001.05469606
42PPAR signaling pathway_Homo sapiens_hsa033201.04954064
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04830579
44Butanoate metabolism_Homo sapiens_hsa006501.00500870
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99800144
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97737307
47Oxidative phosphorylation_Homo sapiens_hsa001900.96544678
48Asthma_Homo sapiens_hsa053100.94753900
49Thyroid hormone synthesis_Homo sapiens_hsa049180.90796899
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.89414618
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.87460876
52Arginine biosynthesis_Homo sapiens_hsa002200.86892621
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85841397
54Parkinsons disease_Homo sapiens_hsa050120.84355770
55Staphylococcus aureus infection_Homo sapiens_hsa051500.82863803
56Chemical carcinogenesis_Homo sapiens_hsa052040.82553119
57Linoleic acid metabolism_Homo sapiens_hsa005910.79310945
58Other glycan degradation_Homo sapiens_hsa005110.78937776
59beta-Alanine metabolism_Homo sapiens_hsa004100.77306730
60Alzheimers disease_Homo sapiens_hsa050100.77253938
61Sphingolipid metabolism_Homo sapiens_hsa006000.76925192
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71312727
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70630429
64Thyroid cancer_Homo sapiens_hsa052160.69626394
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69623327
66Allograft rejection_Homo sapiens_hsa053300.66547478
67Gastric acid secretion_Homo sapiens_hsa049710.66070952
68Tyrosine metabolism_Homo sapiens_hsa003500.65429786
69Bladder cancer_Homo sapiens_hsa052190.65368047
70Salmonella infection_Homo sapiens_hsa051320.65279854
71Arachidonic acid metabolism_Homo sapiens_hsa005900.64233920
72Hepatitis C_Homo sapiens_hsa051600.62505936
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62438127
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61901615
75Autoimmune thyroid disease_Homo sapiens_hsa053200.61430876
76Retinol metabolism_Homo sapiens_hsa008300.59317622
77Adherens junction_Homo sapiens_hsa045200.58333902
78Graft-versus-host disease_Homo sapiens_hsa053320.57080109
79ABC transporters_Homo sapiens_hsa020100.56782295
80Complement and coagulation cascades_Homo sapiens_hsa046100.56387352
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.54367058
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52868777
83Propanoate metabolism_Homo sapiens_hsa006400.51872674
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.51340413
85Fatty acid metabolism_Homo sapiens_hsa012120.49656174
86Metabolic pathways_Homo sapiens_hsa011000.46066535
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45995722
88Vibrio cholerae infection_Homo sapiens_hsa051100.44427915
89Salivary secretion_Homo sapiens_hsa049700.43075025
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.43060169
91Sulfur relay system_Homo sapiens_hsa041220.42816567
92N-Glycan biosynthesis_Homo sapiens_hsa005100.41262594
93Type I diabetes mellitus_Homo sapiens_hsa049400.41094697
94Huntingtons disease_Homo sapiens_hsa050160.40873270
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40748750
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.38733888
97Cardiac muscle contraction_Homo sapiens_hsa042600.36635507
98African trypanosomiasis_Homo sapiens_hsa051430.35288824
99Biosynthesis of amino acids_Homo sapiens_hsa012300.34952770
100Renin secretion_Homo sapiens_hsa049240.33662998
101Fatty acid biosynthesis_Homo sapiens_hsa000610.32758800
102Insulin resistance_Homo sapiens_hsa049310.29564841
103Ether lipid metabolism_Homo sapiens_hsa005650.27868632
104Selenocompound metabolism_Homo sapiens_hsa004500.25465073
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25077833
106Antigen processing and presentation_Homo sapiens_hsa046120.23376398
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23081712
108Pertussis_Homo sapiens_hsa051330.21703171
109Leishmaniasis_Homo sapiens_hsa051400.21656005
110Influenza A_Homo sapiens_hsa051640.19905505
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19634627
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.19074996
113Steroid biosynthesis_Homo sapiens_hsa001000.17870286
114Phenylalanine metabolism_Homo sapiens_hsa003600.17735763
115Peroxisome_Homo sapiens_hsa041460.17677900
116Ribosome_Homo sapiens_hsa030100.17339062
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16368492
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15423048
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14987240
120Toxoplasmosis_Homo sapiens_hsa051450.14962639
121Fatty acid elongation_Homo sapiens_hsa000620.12889554
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12351576
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10304627
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08591763
125Viral myocarditis_Homo sapiens_hsa054160.04145682
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.02862367

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