LGALS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)4.89200323
2response to peptidoglycan (GO:0032494)4.82669526
3neutrophil activation involved in immune response (GO:0002283)4.78665860
4negative regulation of cell killing (GO:0031342)4.75797820
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.75797820
6modulation by symbiont of host defense response (GO:0052031)4.65318408
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.65318408
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.65318408
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.65318408
10modulation by symbiont of host immune response (GO:0052553)4.65318408
11positive regulation by symbiont of host defense response (GO:0052509)4.65318408
12L-phenylalanine catabolic process (GO:0006559)4.47928081
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.47928081
14negative regulation of interleukin-12 production (GO:0032695)4.42127794
15L-phenylalanine metabolic process (GO:0006558)4.37191679
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.37191679
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35196535
18aromatic amino acid family catabolic process (GO:0009074)4.33963346
19detection of other organism (GO:0098543)4.31822546
20macrophage activation involved in immune response (GO:0002281)4.29024929
21detection of bacterium (GO:0016045)4.27821714
22tryptophan catabolic process (GO:0006569)4.20203856
23indole-containing compound catabolic process (GO:0042436)4.20203856
24indolalkylamine catabolic process (GO:0046218)4.20203856
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04111580
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.04111580
27kynurenine metabolic process (GO:0070189)3.96608255
28tryptophan metabolic process (GO:0006568)3.93810870
29interferon-gamma-mediated signaling pathway (GO:0060333)3.93415945
30urea metabolic process (GO:0019627)3.88318557
31urea cycle (GO:0000050)3.88318557
32bile acid biosynthetic process (GO:0006699)3.85949092
33regulation of B cell receptor signaling pathway (GO:0050855)3.84286711
34high-density lipoprotein particle remodeling (GO:0034375)3.84243806
35regulation of gamma-delta T cell activation (GO:0046643)3.77233130
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.76459853
37B cell mediated immunity (GO:0019724)3.76416968
38negative regulation of fibrinolysis (GO:0051918)3.75680624
39alpha-linolenic acid metabolic process (GO:0036109)3.74267300
40positive regulation of antigen processing and presentation (GO:0002579)3.69241427
41regulation of antigen processing and presentation (GO:0002577)3.68207309
42peptidyl-glutamic acid carboxylation (GO:0017187)3.66295109
43protein carboxylation (GO:0018214)3.66295109
44regulation of protein activation cascade (GO:2000257)3.65501784
45complement activation, alternative pathway (GO:0006957)3.61454699
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.60901077
47negative regulation of erythrocyte differentiation (GO:0045647)3.60404475
48regulation of cholesterol esterification (GO:0010872)3.57897244
49nitrogen cycle metabolic process (GO:0071941)3.57715411
50glyoxylate metabolic process (GO:0046487)3.56708931
51detection of external biotic stimulus (GO:0098581)3.55982244
52cysteine metabolic process (GO:0006534)3.55220542
53antigen processing and presentation of endogenous antigen (GO:0019883)3.54072932
54regulation of interferon-beta biosynthetic process (GO:0045357)3.54045692
55blood coagulation, intrinsic pathway (GO:0007597)3.53965549
56sulfur amino acid catabolic process (GO:0000098)3.53816833
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53624074
58phospholipid efflux (GO:0033700)3.53371636
59regulation of fibrinolysis (GO:0051917)3.52133522
60regulation of mast cell degranulation (GO:0043304)3.50362967
61regulation of triglyceride catabolic process (GO:0010896)3.47842645
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45527983
63response to muramyl dipeptide (GO:0032495)3.44526006
64regulation of complement activation (GO:0030449)3.43598986
65protein-lipid complex remodeling (GO:0034368)3.38834658
66macromolecular complex remodeling (GO:0034367)3.38834658
67plasma lipoprotein particle remodeling (GO:0034369)3.38834658
68germinal center formation (GO:0002467)3.37757722
69cellular extravasation (GO:0045123)3.37362399
70reverse cholesterol transport (GO:0043691)3.35546309
71NIK/NF-kappaB signaling (GO:0038061)3.32957360
72defense response to protozoan (GO:0042832)3.32110785
73response to host immune response (GO:0052572)3.30786267
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.30786267
75lipopolysaccharide-mediated signaling pathway (GO:0031663)3.30173747
76positive regulation of lipoprotein lipase activity (GO:0051006)3.29099547
77positive regulation of triglyceride lipase activity (GO:0061365)3.29099547
78myeloid cell activation involved in immune response (GO:0002275)3.28524837
79NAD biosynthetic process (GO:0009435)3.28087930
80respiratory burst (GO:0045730)3.23514057
81lysine catabolic process (GO:0006554)3.22978056
82lysine metabolic process (GO:0006553)3.22978056
83T-helper 1 type immune response (GO:0042088)3.22911275
84neutrophil activation (GO:0042119)3.22465946
85regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21646180
86bile acid metabolic process (GO:0008206)3.21018367
87granulocyte activation (GO:0036230)3.20488193
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19625893
89regulation of mast cell activation involved in immune response (GO:0033006)3.19543946
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18401679
91response to protozoan (GO:0001562)3.18082380
92B cell receptor signaling pathway (GO:0050853)3.17450106
93imidazole-containing compound metabolic process (GO:0052803)3.16578616
94leukocyte aggregation (GO:0070486)3.13716538
95regulation of gamma-delta T cell differentiation (GO:0045586)3.13378899
96regulation of leukocyte degranulation (GO:0043300)3.13323572
97detection of biotic stimulus (GO:0009595)3.12832549
98myeloid dendritic cell differentiation (GO:0043011)3.11705698
99negative regulation of lymphocyte mediated immunity (GO:0002707)3.11325982
100myeloid dendritic cell activation (GO:0001773)3.11272486
101aldehyde catabolic process (GO:0046185)3.10990503
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.10222586
103pyridine nucleotide biosynthetic process (GO:0019363)3.10222586
104negative regulation of cytokine production involved in immune response (GO:0002719)3.10022826
105detection of molecule of bacterial origin (GO:0032490)3.09674307
106positive regulation of mast cell activation (GO:0033005)3.09379453
107aromatic amino acid family metabolic process (GO:0009072)3.09215229
108regulation of interferon-alpha production (GO:0032647)3.08808315
109low-density lipoprotein particle remodeling (GO:0034374)3.07823368
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07696612
111cellular response to interferon-gamma (GO:0071346)3.05786052
112ethanol oxidation (GO:0006069)3.05727439
113amino-acid betaine metabolic process (GO:0006577)3.03751782
114regulation of T cell tolerance induction (GO:0002664)3.03182882
115negative regulation of cholesterol transport (GO:0032375)3.03122216
116negative regulation of sterol transport (GO:0032372)3.03122216
117glycine metabolic process (GO:0006544)3.03036928
118bile acid and bile salt transport (GO:0015721)3.02990521
119microglial cell activation (GO:0001774)3.02590778
120negative regulation of leukocyte mediated immunity (GO:0002704)3.01828131
121negative regulation of T cell mediated immunity (GO:0002710)3.01271886
122response to host (GO:0075136)3.00966768
123response to host defenses (GO:0052200)3.00966768
124response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00966768
125triglyceride homeostasis (GO:0070328)3.00880733
126acylglycerol homeostasis (GO:0055090)3.00880733
127plasma lipoprotein particle assembly (GO:0034377)3.00137732
128plasma lipoprotein particle clearance (GO:0034381)2.99678641
129macrophage activation (GO:0042116)2.99420213
130T cell migration (GO:0072678)2.98593575
131positive thymic T cell selection (GO:0045059)2.98119383
132regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97767180
133positive regulation of type 2 immune response (GO:0002830)2.97185423
134valine metabolic process (GO:0006573)2.96734474
135regulation of mast cell activation (GO:0033003)2.94555613
136regulation of tolerance induction (GO:0002643)2.94218684
137regulation of T-helper 1 cell differentiation (GO:0045625)2.94144293
138negative regulation of innate immune response (GO:0045824)2.91817030
139serine family amino acid catabolic process (GO:0009071)2.91209861
140positive regulation of mast cell degranulation (GO:0043306)2.90766829
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.90766829
142serine family amino acid biosynthetic process (GO:0009070)2.90637480
143cholesterol efflux (GO:0033344)2.89962690
144regulation of B cell differentiation (GO:0045577)2.89867666
145homocysteine metabolic process (GO:0050667)2.89766354
146opsonization (GO:0008228)2.89665955
147positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.88868558
148amine catabolic process (GO:0009310)2.88616214
149cellular biogenic amine catabolic process (GO:0042402)2.88616214
150response to nitrosative stress (GO:0051409)2.88271525
151cofactor catabolic process (GO:0051187)2.88224122
152indolalkylamine metabolic process (GO:0006586)2.87353646
153response to interferon-gamma (GO:0034341)2.86819966
154ribosomal small subunit assembly (GO:0000028)2.86634474
155response to interferon-beta (GO:0035456)2.84303187
156acute-phase response (GO:0006953)2.82807174
157protein activation cascade (GO:0072376)2.82313160
158alpha-amino acid catabolic process (GO:1901606)2.79948149
159positive regulation of B cell differentiation (GO:0045579)2.78978163
160positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.74462309
161tyrosine metabolic process (GO:0006570)2.73454814
162fibrinolysis (GO:0042730)2.73340261
163serine family amino acid metabolic process (GO:0009069)2.73186259
164benzene-containing compound metabolic process (GO:0042537)2.72428965
165plasma lipoprotein particle organization (GO:0071827)2.71012023
166arginine metabolic process (GO:0006525)2.70124836
167disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.69702864
168killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.69702864
169regulation of T-helper 2 cell differentiation (GO:0045628)2.69601287
170positive regulation of gamma-delta T cell activation (GO:0046645)2.68542816
171mature B cell differentiation involved in immune response (GO:0002313)2.68085331
172protein-lipid complex assembly (GO:0065005)2.68055482
173regulation of humoral immune response (GO:0002920)2.66763597
174negative thymic T cell selection (GO:0045060)2.66677156
175regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66494963
176cellular glucuronidation (GO:0052695)2.66148796
177regulation of type 2 immune response (GO:0002828)2.65204279
178response to type I interferon (GO:0034340)2.65141787
179type I interferon signaling pathway (GO:0060337)2.64234357
180cellular response to type I interferon (GO:0071357)2.64234357
181positive regulation of interferon-alpha production (GO:0032727)2.63945654
182cholesterol homeostasis (GO:0042632)2.63352199
183dendritic cell differentiation (GO:0097028)2.62824552
184positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62341456
185positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61839332
186regulation of interleukin-12 production (GO:0032655)2.61709561
187primary alcohol catabolic process (GO:0034310)2.60551080
188amino sugar catabolic process (GO:0046348)2.60335717
189complement activation (GO:0006956)2.58486891
190regulation of lipoprotein particle clearance (GO:0010984)2.57908107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.31439663
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.39044127
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.18360551
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.09611866
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.81222574
6E2F7_22180533_ChIP-Seq_HELA_Human3.76893521
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.24117833
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.12092023
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.99467260
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89743976
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87896463
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.73209181
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.61000965
14GATA1_22025678_ChIP-Seq_K562_Human2.49711253
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47816474
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.34113174
17SCL_19346495_ChIP-Seq_HPC-7_Human2.32212612
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27038371
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.24170163
20* SPI1_23127762_ChIP-Seq_K562_Human2.21618672
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13043285
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08326240
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01484421
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98778984
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93921257
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93509467
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88023310
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79841404
29LXR_22292898_ChIP-Seq_THP-1_Human1.76623801
30TCF7_22412390_ChIP-Seq_EML_Mouse1.76470099
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74109912
32VDR_24787735_ChIP-Seq_THP-1_Human1.73762912
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73523451
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70855328
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.69629098
36* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64739174
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64001686
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63797039
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63634420
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61393339
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60801106
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59554985
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58619348
44KDM2B_26808549_Chip-Seq_DND41_Human1.56630544
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.55310526
46* SPI1_23547873_ChIP-Seq_NB4_Human1.50335128
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49463864
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.48027409
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44610477
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41855184
51* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38422550
52VDR_21846776_ChIP-Seq_THP-1_Human1.37541265
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36615665
54GATA3_27048872_Chip-Seq_THYMUS_Human1.35335893
55MYC_22102868_ChIP-Seq_BL_Human1.34513894
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34435235
57* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34060650
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32931980
59MYB_26560356_Chip-Seq_TH2_Human1.32819590
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.32163829
61MAF_26560356_Chip-Seq_TH1_Human1.32023504
62MYB_26560356_Chip-Seq_TH1_Human1.31134875
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30585145
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29958660
65GATA1_19941826_ChIP-Seq_K562_Human1.29504315
66BCL6_27268052_Chip-Seq_Bcells_Human1.28743590
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27563568
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27478689
69* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27340554
70* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26016906
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24098837
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23972059
73* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23771381
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22903120
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21902709
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20656075
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19360943
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19200686
79* BCOR_27268052_Chip-Seq_Bcells_Human1.18685848
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17429484
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15666116
82* VDR_24763502_ChIP-Seq_THP-1_Human1.14752376
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14749992
84* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13975445
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12926388
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12531135
87UTX_26944678_Chip-Seq_JUKART_Human1.11177475
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10516486
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.10453454
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.10391295
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10149833
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10149561
93* SRF_21415370_ChIP-Seq_HL-1_Mouse1.09868441
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.09502199
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08304363
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06513661
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06146806
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04296520
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02793378
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02757660
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02146195
102GATA3_26560356_Chip-Seq_TH2_Human1.01559816
103EST1_17652178_ChIP-ChIP_JURKAT_Human1.01431604
104E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01294391
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01198346
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00028092
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.99495951
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.98802224
109NCOR1_26117541_ChIP-Seq_K562_Human0.98332728
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98320850
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98260097
112FOXP3_21729870_ChIP-Seq_TREG_Human0.98026228
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97897311
114VDR_23849224_ChIP-Seq_CD4+_Human0.96118969
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94989152
116CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94410586
117RUNX_20019798_ChIP-Seq_JUKART_Human0.94053677
118* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93135126
119STAT1_20625510_ChIP-Seq_HELA_Human0.92824322
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91934426
121* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91628793
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90783620
123AR_21909140_ChIP-Seq_LNCAP_Human0.90488115
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90262033
125RACK7_27058665_Chip-Seq_MCF-7_Human0.89248830
126MAF_26560356_Chip-Seq_TH2_Human0.88321998
127GATA2_19941826_ChIP-Seq_K562_Human0.88138738
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.88108510
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88088693
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86727869
131CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86557155
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84398905
133* PU_27001747_Chip-Seq_BMDM_Mouse0.83734549
134DCP1A_22483619_ChIP-Seq_HELA_Human0.82468606
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81558472
136* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81428613
137* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80461064
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80354839
139ETS1_20019798_ChIP-Seq_JURKAT_Human0.79059041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.98113883
2MP0005360_urolithiasis4.87565857
3MP0005085_abnormal_gallbladder_physiolo3.91403939
4MP0005365_abnormal_bile_salt3.75612893
5MP0003806_abnormal_nucleotide_metabolis3.21515102
6MP0008875_abnormal_xenobiotic_pharmacok3.05002085
7MP0001835_abnormal_antigen_presentation2.68584006
8MP0009840_abnormal_foam_cell2.58704135
9MP0003252_abnormal_bile_duct2.46136702
10MP0009785_altered_susceptibility_to2.45680011
11MP0003191_abnormal_cellular_cholesterol2.42560853
12MP0010329_abnormal_lipoprotein_level2.38845796
13MP0003172_abnormal_lysosome_physiology2.17167727
14MP0003436_decreased_susceptibility_to2.09981760
15MP0003656_abnormal_erythrocyte_physiolo2.02440941
16MP0003186_abnormal_redox_activity1.94555145
17MP0005464_abnormal_platelet_physiology1.90614538
18MP0001666_abnormal_nutrient_absorption1.87345628
19* MP0003724_increased_susceptibility_to1.86874618
20MP0005025_abnormal_response_to1.85729942
21MP0005671_abnormal_response_to1.83695294
22MP0005083_abnormal_biliary_tract1.82974371
23MP0000685_abnormal_immune_system1.80631685
24MP0002138_abnormal_hepatobiliary_system1.80360188
25MP0002396_abnormal_hematopoietic_system1.76060110
26MP0006054_spinal_hemorrhage1.73872017
27MP0000609_abnormal_liver_physiology1.73026087
28MP0005397_hematopoietic_system_phenotyp1.72448692
29MP0001545_abnormal_hematopoietic_system1.72448692
30MP0004510_myositis1.68339769
31MP0001800_abnormal_humoral_immune1.65945664
32MP0001853_heart_inflammation1.63710734
33MP0008469_abnormal_protein_level1.62819097
34MP0009764_decreased_sensitivity_to1.62552951
35MP0002419_abnormal_innate_immunity1.61903095
36MP0005310_abnormal_salivary_gland1.58125799
37MP0002148_abnormal_hypersensitivity_rea1.57898593
38MP0005332_abnormal_amino_acid1.57469786
39MP0005319_abnormal_enzyme/_coenzyme1.56828491
40* MP0005000_abnormal_immune_tolerance1.51232452
41MP0006082_CNS_inflammation1.51003145
42MP0001764_abnormal_homeostasis1.50843722
43MP0002166_altered_tumor_susceptibility1.50379122
44MP0002723_abnormal_immune_serum1.47922723
45MP0010155_abnormal_intestine_physiology1.47919298
46MP0003183_abnormal_peptide_metabolism1.46542592
47MP0002998_abnormal_bone_remodeling1.44286306
48MP0002452_abnormal_antigen_presenting1.43363768
49MP0000604_amyloidosis1.40219771
50MP0001790_abnormal_immune_system1.37392061
51MP0005387_immune_system_phenotype1.37392061
52MP0003866_abnormal_defecation1.36288610
53MP0005584_abnormal_enzyme/coenzyme_acti1.33086684
54MP0001845_abnormal_inflammatory_respons1.32718638
55MP0009697_abnormal_copulation1.32502259
56MP0003763_abnormal_thymus_physiology1.31323762
57MP0001819_abnormal_immune_cell1.30872772
58MP0001873_stomach_inflammation1.30828428
59MP0002420_abnormal_adaptive_immunity1.30753560
60MP0003195_calcinosis1.30414963
61MP0002398_abnormal_bone_marrow1.29612162
62MP0009763_increased_sensitivity_to1.26370206
63MP0009333_abnormal_splenocyte_physiolog1.25384572
64MP0008260_abnormal_autophagy1.24037722
65MP0002118_abnormal_lipid_homeostasis1.23982738
66MP0000689_abnormal_spleen_morphology1.21931929
67MP0004947_skin_inflammation1.21852784
68MP0002132_abnormal_respiratory_system1.20842888
69MP0003828_pulmonary_edema1.20795290
70MP0000598_abnormal_liver_morphology1.20573624
71MP0008004_abnormal_stomach_pH1.18464926
72* MP0000716_abnormal_immune_system1.16907330
73MP0004019_abnormal_vitamin_homeostasis1.16614120
74MP0002722_abnormal_immune_system1.15690728
75MP0002006_tumorigenesis1.13239263
76MP0002405_respiratory_system_inflammati1.12600257
77MP0000465_gastrointestinal_hemorrhage1.10904021
78MP0004147_increased_porphyrin_level1.10430002
79* MP0002429_abnormal_blood_cell1.09961974
80MP0003448_altered_tumor_morphology1.09261628
81MP0003690_abnormal_glial_cell1.08703312
82MP0009643_abnormal_urine_homeostasis1.08441485
83MP0000490_abnormal_crypts_of1.02310106
84MP0003868_abnormal_feces_composition0.99139731
85MP0001851_eye_inflammation0.96797866
86MP0000343_altered_response_to0.92656558
87* MP0001533_abnormal_skeleton_physiology0.92224536
88MP0006036_abnormal_mitochondrial_physio0.91097697
89MP0004883_abnormal_blood_vessel0.89661978
90MP0004808_abnormal_hematopoietic_stem0.89241746
91MP0003075_altered_response_to0.87205117
92MP0010368_abnormal_lymphatic_system0.85971221
93MP0009765_abnormal_xenobiotic_induced0.85968208
94MP0000858_altered_metastatic_potential0.85711196
95MP0005636_abnormal_mineral_homeostasis0.84614021
96MP0002933_joint_inflammation0.83598791
97MP0005075_abnormal_melanosome_morpholog0.82799557
98MP0002277_abnormal_respiratory_mucosa0.82465486
99MP0005164_abnormal_response_to0.81774017
100MP0003300_gastrointestinal_ulcer0.81153616
101MP0009642_abnormal_blood_homeostasis0.80224559
102MP0005167_abnormal_blood-brain_barrier0.79544940
103MP0005451_abnormal_body_composition0.79332179
104MP0005166_decreased_susceptibility_to0.78916033
105* MP0005390_skeleton_phenotype0.78888591
106MP0003453_abnormal_keratinocyte_physiol0.78621755
107MP0009278_abnormal_bone_marrow0.77907811
108MP0008873_increased_physiological_sensi0.77406596
109MP0005084_abnormal_gallbladder_morpholo0.76650607
110MP0003303_peritoneal_inflammation0.75289870
111MP0002019_abnormal_tumor_incidence0.74507808
112MP0005376_homeostasis/metabolism_phenot0.72835021
113MP0003011_delayed_dark_adaptation0.71316065
114MP0003795_abnormal_bone_structure0.71106678
115MP0009379_abnormal_foot_pigmentation0.70082622
116MP0000249_abnormal_blood_vessel0.69584643
117MP0004782_abnormal_surfactant_physiolog0.69018002
118MP0000703_abnormal_thymus_morphology0.68086792
119MP0001663_abnormal_digestive_system0.67422480
120MP0002254_reproductive_system_inflammat0.67317182
121MP0005058_abnormal_lysosome_morphology0.66143672
122MP0008874_decreased_physiological_sensi0.64781592
123MP0005381_digestive/alimentary_phenotyp0.64713442
124MP0003091_abnormal_cell_migration0.61583085
125MP0005165_increased_susceptibility_to0.60859673
126MP0003045_fibrosis0.60200294
127MP0000920_abnormal_myelination0.59764901
128MP0003329_amyloid_beta_deposits0.55539400
129MP0005535_abnormal_body_temperature0.47845488
130MP0002136_abnormal_kidney_physiology0.46953876

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)5.10246519
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.86404128
3Intrahepatic cholestasis (HP:0001406)4.69823223
4Deep venous thrombosis (HP:0002625)4.67744171
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.66846555
6Prolonged partial thromboplastin time (HP:0003645)4.59620593
7Abnormality of liposaccharide metabolism (HP:0010968)4.58411666
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.58411666
9Abnormality of glycolipid metabolism (HP:0010969)4.58411666
10Hypobetalipoproteinemia (HP:0003563)4.42678461
11Orchitis (HP:0100796)4.10524461
12Mediastinal lymphadenopathy (HP:0100721)4.04859794
13Joint hemorrhage (HP:0005261)3.87358892
14Xanthomatosis (HP:0000991)3.86554604
15Optic neuritis (HP:0100653)3.84317896
16Retrobulbar optic neuritis (HP:0100654)3.84317896
17Increased cerebral lipofuscin (HP:0011813)3.78395442
18Chronic obstructive pulmonary disease (HP:0006510)3.73281065
19Obstructive lung disease (HP:0006536)3.73281065
20Meningitis (HP:0001287)3.72257612
21Stomatitis (HP:0010280)3.68802466
22Complement deficiency (HP:0004431)3.55940467
23Hyperlipoproteinemia (HP:0010980)3.44893062
24Vasculitis (HP:0002633)3.34827375
25Recurrent cutaneous fungal infections (HP:0011370)3.34635478
26Chronic mucocutaneous candidiasis (HP:0002728)3.34635478
27Abnormality of the common coagulation pathway (HP:0010990)3.34005377
28Abnormality of pyrimidine metabolism (HP:0004353)3.30980388
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.30271487
30Hyperammonemia (HP:0001987)3.25416007
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.25312109
32Increased IgE level (HP:0003212)3.22374100
33Dysostosis multiplex (HP:0000943)3.21233927
34Loss of speech (HP:0002371)3.19329410
35Gingival bleeding (HP:0000225)3.15746370
36Recurrent gram-negative bacterial infections (HP:0005420)3.13521037
37Petechiae (HP:0000967)3.09555478
38Cellulitis (HP:0100658)3.05055118
39Hypolipoproteinemia (HP:0010981)3.04996779
40Encephalitis (HP:0002383)3.02837133
41Hyperbilirubinemia (HP:0002904)3.00666226
42Autoimmune thrombocytopenia (HP:0001973)2.99892391
43Fat malabsorption (HP:0002630)2.99318617
44Systemic lupus erythematosus (HP:0002725)2.98012368
45Urticaria (HP:0001025)2.96861837
46Pulmonary infiltrates (HP:0002113)2.94256267
47Agammaglobulinemia (HP:0004432)2.92797175
48Gingivitis (HP:0000230)2.91996710
49Epistaxis (HP:0000421)2.91736328
50Hypoglycemic coma (HP:0001325)2.89727764
51Gastrointestinal infarctions (HP:0005244)2.88794789
52Elevated erythrocyte sedimentation rate (HP:0003565)2.88009277
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.86692366
54Abnormality of the intrinsic pathway (HP:0010989)2.86017946
55Hemoptysis (HP:0002105)2.85283497
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.84456152
57Colitis (HP:0002583)2.81701805
58Abnormality of complement system (HP:0005339)2.81047163
59Panhypogammaglobulinemia (HP:0003139)2.79615299
60Acanthocytosis (HP:0001927)2.78735664
61Inflammation of the large intestine (HP:0002037)2.78135853
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.77295410
63Abnormality of fatty-acid metabolism (HP:0004359)2.77041747
64Keratoconjunctivitis sicca (HP:0001097)2.75033249
65Disinhibition (HP:0000734)2.72150456
66Gastrointestinal inflammation (HP:0004386)2.71747842
67Abnormality of methionine metabolism (HP:0010901)2.69949246
68Abnormality of sulfur amino acid metabolism (HP:0004339)2.68843197
69Purpura (HP:0000979)2.67347309
70Prolonged bleeding time (HP:0003010)2.67072591
71Gastrointestinal stroma tumor (HP:0100723)2.66833961
72Reduced antithrombin III activity (HP:0001976)2.63980849
73Recurrent bacterial skin infections (HP:0005406)2.62816848
74Increased IgM level (HP:0003496)2.62646616
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62469602
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61198684
77Hypoplasia of the thymus (HP:0000778)2.59958411
78Hypercholesterolemia (HP:0003124)2.58255449
79Epidermoid cyst (HP:0200040)2.55794503
80Menorrhagia (HP:0000132)2.54348153
81Abnormal platelet function (HP:0011869)2.53171870
82Impaired platelet aggregation (HP:0003540)2.53171870
83Abnormality of iron homeostasis (HP:0011031)2.53133671
84Chronic otitis media (HP:0000389)2.53055211
85Increased serum ferritin (HP:0003281)2.51392456
86Keratoconjunctivitis (HP:0001096)2.51254206
87Chest pain (HP:0100749)2.49618830
88Conjugated hyperbilirubinemia (HP:0002908)2.49071436
89Osteomyelitis (HP:0002754)2.47267012
90Abnormal number of erythroid precursors (HP:0012131)2.45553700
91Thrombocytosis (HP:0001894)2.45482657
92Hypergammaglobulinemia (HP:0010702)2.44329994
93Steatorrhea (HP:0002570)2.42259434
94Recurrent abscess formation (HP:0002722)2.41725506
95Recurrent viral infections (HP:0004429)2.41222947
96Ketosis (HP:0001946)2.39367179
97Abnormality of nucleobase metabolism (HP:0010932)2.38648418
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37922276
99Abnormality of polysaccharide metabolism (HP:0011012)2.37922276
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37922276
101Abnormal platelet volume (HP:0011876)2.37310433
102Malnutrition (HP:0004395)2.37075166
103Hypoalphalipoproteinemia (HP:0003233)2.36088334
104Leukocytosis (HP:0001974)2.35279326
105Hepatosplenomegaly (HP:0001433)2.32305517
106Thrombophlebitis (HP:0004418)2.32264064
107T lymphocytopenia (HP:0005403)2.31586222
108Eczematoid dermatitis (HP:0000976)2.30213773
109Abnormality of transition element cation homeostasis (HP:0011030)2.30018969
110Abnormality of cells of the erythroid lineage (HP:0012130)2.26518041
111Increased mean platelet volume (HP:0011877)2.25908679
112Restrictive lung disease (HP:0002091)2.25626366
113Generalized aminoaciduria (HP:0002909)2.25509098
114Abnormality of T cell number (HP:0011839)2.24676983
115Mucopolysacchariduria (HP:0008155)2.24662992
116Urinary glycosaminoglycan excretion (HP:0003541)2.24662992
117Poikilocytosis (HP:0004447)2.24022082
118Nausea (HP:0002018)2.21498778
119Granulocytopenia (HP:0001913)2.20951957
120Spastic diplegia (HP:0001264)2.20445018
121Hyperglycinemia (HP:0002154)2.18967058
122Arterial thrombosis (HP:0004420)2.18879056
123Autoimmune hemolytic anemia (HP:0001890)2.18537606
124Lymphopenia (HP:0001888)2.18431195
125Hematochezia (HP:0002573)2.17747689
126Dicarboxylic aciduria (HP:0003215)2.16718521
127Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16718521
128Hepatocellular carcinoma (HP:0001402)2.15909788
129Myocardial infarction (HP:0001658)2.15470102
130Microcytic anemia (HP:0001935)2.15181329
131Recurrent skin infections (HP:0001581)2.14503451
132Recurrent sinusitis (HP:0011108)2.14414001
133Interstitial pulmonary disease (HP:0006530)2.13472377
134Premature loss of primary teeth (HP:0006323)2.13256455
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12800278
136Recurrent fungal infections (HP:0002841)2.12633733
137Spontaneous hematomas (HP:0007420)2.12068491
138Glomerulonephritis (HP:0000099)2.11954465
139Abnormality of the pleura (HP:0002103)2.11734056
140Abnormality of the nasal mucosa (HP:0000433)2.11149725
141Myositis (HP:0100614)2.10058663
142Mutism (HP:0002300)2.09513023
143IgM deficiency (HP:0002850)2.09501212
144Abnormality of cells of the lymphoid lineage (HP:0012140)2.06617068
145Abnormality of T cell physiology (HP:0011840)2.06334524
146Spontaneous abortion (HP:0005268)2.05868520
147Esophageal varix (HP:0002040)2.04933534
148Recurrent pneumonia (HP:0006532)2.04824577
149Hyperglycinuria (HP:0003108)2.04821384
150Sepsis (HP:0100806)2.02954765
151Polycythemia (HP:0001901)2.02857065
152Abnormality of serine family amino acid metabolism (HP:0010894)2.02445238
153Abnormality of glycine metabolism (HP:0010895)2.02445238
154Pustule (HP:0200039)2.02112381
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01876518
156Gangrene (HP:0100758)2.00349562
157Episodic fever (HP:0001954)1.99237259
158Pulmonary embolism (HP:0002204)1.98485940
159Metabolic acidosis (HP:0001942)1.98279945
160Aplastic anemia (HP:0001915)1.97030155
161Nonimmune hydrops fetalis (HP:0001790)1.96864290
162Polyneuropathy (HP:0001271)1.96622026
163Abnormality of T cells (HP:0002843)1.95189757
164Axonal loss (HP:0003447)1.94792506
165Amyloidosis (HP:0011034)1.94307921
166Abnormality of serum amino acid levels (HP:0003112)1.93025859
167Abnormality of purine metabolism (HP:0004352)1.92482433
168Vacuolated lymphocytes (HP:0001922)1.91284113
169Recurrent bronchitis (HP:0002837)1.91236962
170Combined immunodeficiency (HP:0005387)1.90818467
171Joint swelling (HP:0001386)1.89633252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.39117456
2ERN13.18276174
3MAP4K12.85072733
4TBK12.77391867
5TYK22.68998737
6BCKDK2.58113201
7KDR2.54985527
8PRPF4B2.54639470
9NME22.48900550
10IKBKE2.40222605
11PIM22.36162820
12KIT2.34042841
13FGFR42.25925944
14TAOK32.17941552
15MAP3K142.14635194
16JAK32.04360260
17TIE11.96153983
18TNK21.87420590
19ZAP701.87051701
20BTK1.85574799
21TEC1.83677417
22BLK1.81926021
23FLT31.74085953
24TXK1.73043281
25MAP2K31.71505713
26STK161.67563870
27IRAK41.64579313
28MAP3K131.64477041
29FGR1.58359349
30TGFBR11.54205178
31TGFBR21.51649418
32TAOK11.50930204
33MAP3K101.44799469
34PKN21.39469664
35IKBKB1.34879481
36TAOK21.33472544
37EIF2AK11.32098851
38JAK11.27820875
39SYK1.25641787
40GRK71.23370468
41CSF1R1.21955993
42MAPK111.19694181
43EEF2K1.15049073
44MAP3K11.14352332
45GRK61.14060896
46RPS6KA41.13106030
47NEK91.13085913
48BMPR21.12954684
49SIK31.11766381
50SIK11.11288621
51PIM11.10919234
52CDC42BPA1.09937591
53ACVR1B1.03940234
54IRAK31.03468234
55STK101.03292182
56PIK3CG0.99635948
57LRRK20.98722253
58MATK0.98241621
59LYN0.96998231
60MARK30.95774494
61MAP3K110.95647518
62JAK20.94440781
63SMG10.92461553
64ABL20.90677752
65CSK0.89569463
66MAPK40.85426017
67RPS6KB20.85222282
68BUB10.84415766
69CDK40.83595322
70TESK20.81048713
71LCK0.80940528
72PDK10.79083235
73WEE10.78299457
74VRK10.76899100
75ITK0.76842561
76SCYL20.76573487
77STK40.76139018
78PBK0.75000020
79IRAK10.74930855
80CHUK0.74484934
81MAP2K60.73647321
82PDPK10.73196955
83HIPK20.72075698
84PTK60.71966222
85EIF2AK30.71549799
86SIK20.70036197
87MAPK70.68889281
88NLK0.67920956
89CDK60.67007911
90HCK0.66618555
91MST1R0.64855395
92MARK20.63845091
93RIPK10.62878555
94PRKCQ0.62824381
95PRKD20.62314005
96CDC70.61809763
97TRIB30.59873939
98IRAK20.57167871
99MAP3K30.56610540
100DDR20.55954042
101MAPKAPK30.55767193
102RPS6KL10.55624282
103RPS6KC10.55624282
104NEK20.54926981
105FGFR30.54100053
106MAP3K60.53569056
107MST40.53334601
108EIF2AK20.53117562
109CDK70.52960356
110BRSK20.52950717
111FYN0.52819394
112MAP3K120.52514912
113PRKG20.50744163
114MAP3K50.46319816
115ATR0.45800500
116EPHA30.45424419
117PAK40.45023633
118MOS0.44762606
119CDK190.41928137
120EPHB10.41589389
121MYLK0.41386597
122CLK10.41129803
123KSR20.39662350
124MAP3K80.39395819
125MAPK120.38962472
126DYRK30.38708542
127MAPKAPK20.38115712
128YES10.37901363
129PRKCD0.37552618
130CDK80.37275173
131FES0.35925869
132RPS6KA20.35256013
133TRPM70.34982829
134RPS6KA60.34072343
135ABL10.33094997
136DAPK20.31994502
137MAP2K20.31922674
138MAP3K70.31503927
139CAMKK20.30131635

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.79439260
2Autoimmune thyroid disease_Homo sapiens_hsa053203.01143748
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94323236
4Complement and coagulation cascades_Homo sapiens_hsa046102.54440075
5Type I diabetes mellitus_Homo sapiens_hsa049402.39457039
6Staphylococcus aureus infection_Homo sapiens_hsa051502.33229321
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28427243
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26610764
9Arginine biosynthesis_Homo sapiens_hsa002202.22585786
10Tuberculosis_Homo sapiens_hsa051522.16893558
11Nitrogen metabolism_Homo sapiens_hsa009102.16632754
12Tryptophan metabolism_Homo sapiens_hsa003802.12859796
13Caffeine metabolism_Homo sapiens_hsa002322.04210034
14Fatty acid degradation_Homo sapiens_hsa000712.03216640
15Rheumatoid arthritis_Homo sapiens_hsa053231.95621148
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.91526571
17Viral myocarditis_Homo sapiens_hsa054161.84434045
18Peroxisome_Homo sapiens_hsa041461.84018844
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82260987
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81881140
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74449834
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74174578
23Lysosome_Homo sapiens_hsa041421.73591613
24Folate biosynthesis_Homo sapiens_hsa007901.73193837
25Histidine metabolism_Homo sapiens_hsa003401.72771319
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66832414
27Chemical carcinogenesis_Homo sapiens_hsa052041.64635870
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59626221
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58200285
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57002406
31DNA replication_Homo sapiens_hsa030301.53537783
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51558834
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47765935
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47220633
35Phagosome_Homo sapiens_hsa041451.46759487
36beta-Alanine metabolism_Homo sapiens_hsa004101.46510234
37Selenocompound metabolism_Homo sapiens_hsa004501.39317179
38PPAR signaling pathway_Homo sapiens_hsa033201.38704376
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38279605
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36866764
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.36574370
42TNF signaling pathway_Homo sapiens_hsa046681.36266794
43One carbon pool by folate_Homo sapiens_hsa006701.34457778
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.31406887
45Acute myeloid leukemia_Homo sapiens_hsa052211.31024720
46Retinol metabolism_Homo sapiens_hsa008301.28724436
47Sulfur relay system_Homo sapiens_hsa041221.28625494
48Chemokine signaling pathway_Homo sapiens_hsa040621.27659437
49Pentose phosphate pathway_Homo sapiens_hsa000301.26668208
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24571526
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.24418768
52Propanoate metabolism_Homo sapiens_hsa006401.23375031
53Primary immunodeficiency_Homo sapiens_hsa053401.22997994
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17470529
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14613243
56ABC transporters_Homo sapiens_hsa020101.12906970
57T cell receptor signaling pathway_Homo sapiens_hsa046601.11197799
58Fatty acid metabolism_Homo sapiens_hsa012121.09765014
59Starch and sucrose metabolism_Homo sapiens_hsa005001.09004362
60Ribosome_Homo sapiens_hsa030101.08467863
61Salmonella infection_Homo sapiens_hsa051321.06445266
62Leishmaniasis_Homo sapiens_hsa051401.02997945
63Fat digestion and absorption_Homo sapiens_hsa049751.02175787
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99475914
65Phenylalanine metabolism_Homo sapiens_hsa003600.98275708
66Hepatitis B_Homo sapiens_hsa051610.96358628
67Biosynthesis of amino acids_Homo sapiens_hsa012300.94587765
68Carbon metabolism_Homo sapiens_hsa012000.93145422
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93098256
70Vitamin digestion and absorption_Homo sapiens_hsa049770.90850164
71Measles_Homo sapiens_hsa051620.90507614
72Butanoate metabolism_Homo sapiens_hsa006500.88900504
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.87593818
74Bile secretion_Homo sapiens_hsa049760.87592128
75Pyruvate metabolism_Homo sapiens_hsa006200.87128788
76Tyrosine metabolism_Homo sapiens_hsa003500.86396975
77Proteasome_Homo sapiens_hsa030500.86039333
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85888120
79Legionellosis_Homo sapiens_hsa051340.85583668
80Shigellosis_Homo sapiens_hsa051310.85338478
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.84922959
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84302824
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.83902797
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.83206543
85Apoptosis_Homo sapiens_hsa042100.83141901
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81547145
87Pyrimidine metabolism_Homo sapiens_hsa002400.79871989
88Glutathione metabolism_Homo sapiens_hsa004800.79652089
89Platelet activation_Homo sapiens_hsa046110.79557438
90Sulfur metabolism_Homo sapiens_hsa009200.77673600
91Base excision repair_Homo sapiens_hsa034100.75249337
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73595773
93Epstein-Barr virus infection_Homo sapiens_hsa051690.73391884
94Antigen processing and presentation_Homo sapiens_hsa046120.73357254
95Mismatch repair_Homo sapiens_hsa034300.73018861
96Herpes simplex infection_Homo sapiens_hsa051680.72462048
97Hematopoietic cell lineage_Homo sapiens_hsa046400.71998508
98Fatty acid elongation_Homo sapiens_hsa000620.71505243
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71359052
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71089445
101Pertussis_Homo sapiens_hsa051330.67758247
102Allograft rejection_Homo sapiens_hsa053300.66394234
103Systemic lupus erythematosus_Homo sapiens_hsa053220.63608170
104Arginine and proline metabolism_Homo sapiens_hsa003300.63124435
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61224645
106Graft-versus-host disease_Homo sapiens_hsa053320.60433880
107Galactose metabolism_Homo sapiens_hsa000520.60417099
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58357260
109Malaria_Homo sapiens_hsa051440.58092200
110Influenza A_Homo sapiens_hsa051640.56933307
111Pancreatic cancer_Homo sapiens_hsa052120.55576715
112VEGF signaling pathway_Homo sapiens_hsa043700.53935729
113Prolactin signaling pathway_Homo sapiens_hsa049170.53784917
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53480295
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.52672616
116Amoebiasis_Homo sapiens_hsa051460.52340031
117Chronic myeloid leukemia_Homo sapiens_hsa052200.52053767
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51830837
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.51335232
120HTLV-I infection_Homo sapiens_hsa051660.50990097
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50219125
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49845179
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49750129
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.47234947
125Steroid biosynthesis_Homo sapiens_hsa001000.46841935
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46418582
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.46357634
128Collecting duct acid secretion_Homo sapiens_hsa049660.46077067
129Viral carcinogenesis_Homo sapiens_hsa052030.44394765
130Non-small cell lung cancer_Homo sapiens_hsa052230.43719324
131Endocytosis_Homo sapiens_hsa041440.43057493
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41497133
133Metabolic pathways_Homo sapiens_hsa011000.41144268
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40929467
135Homologous recombination_Homo sapiens_hsa034400.40108345
136Lysine degradation_Homo sapiens_hsa003100.39459737
137Asthma_Homo sapiens_hsa053100.39397749
138Notch signaling pathway_Homo sapiens_hsa043300.39165679
139Prion diseases_Homo sapiens_hsa050200.38784983
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.38614126
141African trypanosomiasis_Homo sapiens_hsa051430.38580839
142Bladder cancer_Homo sapiens_hsa052190.36784312
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36223585
144B cell receptor signaling pathway_Homo sapiens_hsa046620.34727972
145Osteoclast differentiation_Homo sapiens_hsa043800.34573511
146Nucleotide excision repair_Homo sapiens_hsa034200.33553667
147Glycerolipid metabolism_Homo sapiens_hsa005610.33279229
148Hepatitis C_Homo sapiens_hsa051600.33217985
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.32462791
150Other glycan degradation_Homo sapiens_hsa005110.32202448
151Toxoplasmosis_Homo sapiens_hsa051450.31825263
152GnRH signaling pathway_Homo sapiens_hsa049120.27271370
153Fructose and mannose metabolism_Homo sapiens_hsa000510.27154947
154HIF-1 signaling pathway_Homo sapiens_hsa040660.26970684
155Insulin resistance_Homo sapiens_hsa049310.26546688
156Renin-angiotensin system_Homo sapiens_hsa046140.25854189
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.24966080
158Renal cell carcinoma_Homo sapiens_hsa052110.21718149
159Arachidonic acid metabolism_Homo sapiens_hsa005900.21065144
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19737754
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19026419
162Sphingolipid metabolism_Homo sapiens_hsa006000.18620284
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16906673
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15646055
165Type II diabetes mellitus_Homo sapiens_hsa049300.15297475
166MAPK signaling pathway_Homo sapiens_hsa040100.14869844

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