LGALS9C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more telomeric gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.18959052
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.04738731
3regulation of B cell receptor signaling pathway (GO:0050855)6.01255535
4negative regulation of cell killing (GO:0031342)5.93977937
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.93977937
6antigen processing and presentation of endogenous antigen (GO:0019883)5.73981497
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.49600766
8negative regulation of phagocytosis (GO:0050765)5.32634305
9regulation of activation of Janus kinase activity (GO:0010533)5.30273593
10positive regulation of gamma-delta T cell activation (GO:0046645)4.51418621
11neutrophil activation involved in immune response (GO:0002283)4.43648903
12regulation of mast cell degranulation (GO:0043304)4.29079034
13detection of bacterium (GO:0016045)4.13406722
14negative regulation of leukocyte mediated immunity (GO:0002704)4.06887411
15detection of other organism (GO:0098543)4.03923128
16cellular response to interleukin-15 (GO:0071350)3.97229365
17leukocyte aggregation (GO:0070486)3.95652757
18regulation of mast cell activation involved in immune response (GO:0033006)3.94044778
19immunoglobulin mediated immune response (GO:0016064)3.89419974
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84745144
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84745144
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.84745144
23modulation by symbiont of host immune response (GO:0052553)3.84745144
24positive regulation by symbiont of host defense response (GO:0052509)3.84745144
25modulation by symbiont of host defense response (GO:0052031)3.84745144
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.84397954
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78417457
28positive regulation of T cell mediated cytotoxicity (GO:0001916)3.72972394
29response to interleukin-15 (GO:0070672)3.71788452
30regulation of myeloid leukocyte mediated immunity (GO:0002886)3.67267166
31regulation of T cell mediated cytotoxicity (GO:0001914)3.64359033
32regulation of leukocyte degranulation (GO:0043300)3.57725581
33negative regulation of alpha-beta T cell activation (GO:0046636)3.52448955
34tolerance induction (GO:0002507)3.52222349
35response to type I interferon (GO:0034340)3.50179879
36regulation of gamma-delta T cell activation (GO:0046643)3.46691105
37cellular response to type I interferon (GO:0071357)3.45942448
38type I interferon signaling pathway (GO:0060337)3.45942448
39neutrophil activation (GO:0042119)3.37144196
40granulocyte activation (GO:0036230)3.36025852
41axonemal dynein complex assembly (GO:0070286)3.35388632
42regulation of mast cell activation (GO:0033003)3.34486732
43respiratory burst (GO:0045730)3.33434256
44macrophage activation involved in immune response (GO:0002281)3.30908099
45regulation of gamma-delta T cell differentiation (GO:0045586)3.24083916
46positive thymic T cell selection (GO:0045059)3.23774556
47leukocyte migration involved in inflammatory response (GO:0002523)3.23263204
48B cell receptor signaling pathway (GO:0050853)3.21551507
49regulation of cellular extravasation (GO:0002691)3.19963517
50negative regulation of mast cell activation (GO:0033004)3.15075262
51regulation of tolerance induction (GO:0002643)3.13919541
52positive regulation of interleukin-17 production (GO:0032740)3.12054993
53detection of external biotic stimulus (GO:0098581)3.11823649
54regulation of memory T cell differentiation (GO:0043380)3.11349048
55interferon-gamma-mediated signaling pathway (GO:0060333)3.07017396
56negative thymic T cell selection (GO:0045060)3.06332185
57B cell mediated immunity (GO:0019724)3.03596144
58negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.01693021
59negative regulation of interleukin-12 production (GO:0032695)3.01250639
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.00459976
61negative regulation of B cell proliferation (GO:0030889)2.99846245
62negative T cell selection (GO:0043383)2.99351912
63positive regulation of B cell differentiation (GO:0045579)2.98191943
64myeloid cell activation involved in immune response (GO:0002275)2.97895787
65regulation of regulated secretory pathway (GO:1903305)2.96898938
66positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.94540706
67regulation of B cell differentiation (GO:0045577)2.93772851
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91620109
69antigen processing and presentation via MHC class Ib (GO:0002475)2.91320110
70regulation of natural killer cell mediated immunity (GO:0002715)2.90468452
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90468452
72regulation of alpha-beta T cell proliferation (GO:0046640)2.84480323
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83572461
74positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81133268
75cilium or flagellum-dependent cell motility (GO:0001539)2.81074122
76negative regulation of innate immune response (GO:0045824)2.79966793
77response to peptidoglycan (GO:0032494)2.78379062
78leukocyte degranulation (GO:0043299)2.78074449
79positive regulation of tolerance induction (GO:0002645)2.77586429
80cytidine metabolic process (GO:0046087)2.75849855
81cytidine catabolic process (GO:0006216)2.75849855
82cytidine deamination (GO:0009972)2.75849855
83positive regulation of mast cell activation (GO:0033005)2.74561836
84response to host immune response (GO:0052572)2.74092289
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74092289
86motile cilium assembly (GO:0044458)2.73107674
87negative regulation of T cell mediated immunity (GO:0002710)2.71182048
88regulation of interferon-beta biosynthetic process (GO:0045357)2.69321968
89regulation of cell killing (GO:0031341)2.67195258
90regulation of T cell tolerance induction (GO:0002664)2.63893834
91positive regulation of cell killing (GO:0031343)2.63213207
92regulation of T cell mediated immunity (GO:0002709)2.62856830
93cellular extravasation (GO:0045123)2.61904617
94detection of biotic stimulus (GO:0009595)2.61182836
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60831827
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57861079
97regulation of leukocyte mediated immunity (GO:0002703)2.57714573
98pyrimidine ribonucleoside catabolic process (GO:0046133)2.56729433
99thymic T cell selection (GO:0045061)2.53981098
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.53122695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.39735282
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.40398252
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.16128261
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.18871453
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84557265
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69533483
7RUNX_20019798_ChIP-Seq_JUKART_Human2.48610370
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.40840331
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40299794
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35915107
11VDR_24763502_ChIP-Seq_THP-1_Human2.33999090
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33022215
13VDR_21846776_ChIP-Seq_THP-1_Human2.28645964
14MYB_26560356_Chip-Seq_TH2_Human2.23553757
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20140575
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19908299
17* SPI1_23547873_ChIP-Seq_NB4_Human2.06732441
18MAF_26560356_Chip-Seq_TH1_Human2.06495740
19UTX_26944678_Chip-Seq_JUKART_Human2.05290883
20RUNX1_22412390_ChIP-Seq_EML_Mouse2.01284312
21SPI1_23127762_ChIP-Seq_K562_Human2.00508526
22SCL_19346495_ChIP-Seq_HPC-7_Human2.00061385
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99196735
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98593292
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93392505
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92437670
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91761279
28* MYB_26560356_Chip-Seq_TH1_Human1.85339437
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82834795
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73557914
31LXR_22292898_ChIP-Seq_THP-1_Human1.69578222
32BCL6_27268052_Chip-Seq_Bcells_Human1.69396828
33MYC_22102868_ChIP-Seq_BL_Human1.68886066
34GATA3_27048872_Chip-Seq_THYMUS_Human1.67754419
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62712873
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62564981
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61968238
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61624635
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61074737
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60080997
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53250524
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50631114
43MAF_26560356_Chip-Seq_TH2_Human1.50443361
44TCF7_22412390_ChIP-Seq_EML_Mouse1.48937521
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48615805
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48336229
47BCOR_27268052_Chip-Seq_Bcells_Human1.48334095
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43207534
49GATA3_26560356_Chip-Seq_TH2_Human1.39690233
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39506081
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38762725
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.37418576
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36785814
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.35095783
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34879362
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32635011
57GATA1_19941826_ChIP-Seq_K562_Human1.31689237
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.30433559
59VDR_24787735_ChIP-Seq_THP-1_Human1.26273561
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25909104
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.25788137
62P68_20966046_ChIP-Seq_HELA_Human1.19814137
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19542668
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17339755
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16932773
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16572169
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16441997
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16104072
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.15466965
70STAT1_20625510_ChIP-Seq_HELA_Human1.14640475
71KDM2B_26808549_Chip-Seq_DND41_Human1.13962176
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13813762
73DROSHA_22980978_ChIP-Seq_HELA_Human1.13480475
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13061900
75SA1_27219007_Chip-Seq_Bcells_Human1.13030304
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12712254
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.12686858
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12296888
79P300_27268052_Chip-Seq_Bcells_Human1.10827640
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10555235
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09881771
82CTCF_20526341_ChIP-Seq_ESCs_Human1.07522058
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07413075
84GATA2_19941826_ChIP-Seq_K562_Human1.06792982
85RACK7_27058665_Chip-Seq_MCF-7_Human1.05587864
86SMC4_20622854_ChIP-Seq_HELA_Human1.04697444
87* E2F1_20622854_ChIP-Seq_HELA_Human1.04257000
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.04220696
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03963961
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03886405
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02448346
92GATA1_22025678_ChIP-Seq_K562_Human1.01773904
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01747055
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01575721
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01357046
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99095212
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99071980
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98975682
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98805351
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.97765677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.15387420
2MP0001835_abnormal_antigen_presentation3.46629442
3MP0005671_abnormal_response_to3.35767303
4MP0003436_decreased_susceptibility_to3.31571102
5MP0003303_peritoneal_inflammation3.30999253
6MP0010155_abnormal_intestine_physiology2.86712425
7MP0005025_abnormal_response_to2.80369676
8MP0003763_abnormal_thymus_physiology2.79377284
9MP0009785_altered_susceptibility_to2.72095055
10MP0003866_abnormal_defecation2.69401658
11MP0001800_abnormal_humoral_immune2.68718503
12MP0006082_CNS_inflammation2.66233024
13MP0005387_immune_system_phenotype2.61815168
14MP0001790_abnormal_immune_system2.61815168
15MP0005000_abnormal_immune_tolerance2.57103670
16MP0003183_abnormal_peptide_metabolism2.52394090
17MP0002419_abnormal_innate_immunity2.48683338
18MP0002723_abnormal_immune_serum2.35089710
19MP0001819_abnormal_immune_cell2.27524947
20MP0002420_abnormal_adaptive_immunity2.27146221
21MP0002452_abnormal_antigen_presenting2.25567232
22MP0003191_abnormal_cellular_cholesterol2.22901254
23MP0005464_abnormal_platelet_physiology2.21481221
24MP0000685_abnormal_immune_system2.18210478
25MP0002148_abnormal_hypersensitivity_rea2.15949305
26MP0002132_abnormal_respiratory_system2.07428734
27MP0003300_gastrointestinal_ulcer1.90859254
28MP0001845_abnormal_inflammatory_respons1.83250614
29MP0001533_abnormal_skeleton_physiology1.80928157
30MP0002139_abnormal_hepatobiliary_system1.78761934
31MP0009333_abnormal_splenocyte_physiolog1.78020305
32MP0002405_respiratory_system_inflammati1.76267330
33MP0000490_abnormal_crypts_of1.74490559
34MP0000716_abnormal_immune_system1.65600742
35MP0002398_abnormal_bone_marrow1.64451161
36MP0000465_gastrointestinal_hemorrhage1.62170952
37MP0001873_stomach_inflammation1.60730975
38MP0004947_skin_inflammation1.52449656
39MP0001663_abnormal_digestive_system1.50689311
40MP0001765_abnormal_ion_homeostasis1.48380332
41MP0008469_abnormal_protein_level1.44526434
42MP0005166_decreased_susceptibility_to1.43502757
43MP0005310_abnormal_salivary_gland1.39766229
44MP0010234_abnormal_vibrissa_follicle1.39563819
45MP0005360_urolithiasis1.39409621
46MP0004043_abnormal_pH_regulation1.38807413
47MP0002138_abnormal_hepatobiliary_system1.37945782
48MP0005085_abnormal_gallbladder_physiolo1.35989892
49MP0002277_abnormal_respiratory_mucosa1.35098948
50MP0002722_abnormal_immune_system1.34130479
51MP0002429_abnormal_blood_cell1.34046719
52MP0005377_hearing/vestibular/ear_phenot1.33858538
53MP0003878_abnormal_ear_physiology1.33858538
54MP0002166_altered_tumor_susceptibility1.33716662
55MP0005451_abnormal_body_composition1.32190716
56MP0000689_abnormal_spleen_morphology1.29712430
57MP0004264_abnormal_extraembryonic_tissu1.28366553
58MP0000858_altered_metastatic_potential1.20465942
59MP0005075_abnormal_melanosome_morpholog1.15680571
60MP0001664_abnormal_digestion1.15482373
61MP0003806_abnormal_nucleotide_metabolis1.15294083
62MP0000703_abnormal_thymus_morphology1.10854212
63MP0009764_decreased_sensitivity_to1.10566081
64MP0003075_altered_response_to1.09639566
65MP0009840_abnormal_foam_cell1.07468484
66MP0000678_abnormal_parathyroid_gland1.07199981
67MP0005381_digestive/alimentary_phenotyp1.03772637
68MP0009278_abnormal_bone_marrow1.00171219
69MP0001851_eye_inflammation0.98873846
70MP0008875_abnormal_xenobiotic_pharmacok0.96813950
71MP0000477_abnormal_intestine_morphology0.96362185
72MP0002396_abnormal_hematopoietic_system0.95655031
73MP0004019_abnormal_vitamin_homeostasis0.95287547
74MP0001545_abnormal_hematopoietic_system0.93222589
75MP0005397_hematopoietic_system_phenotyp0.93222589
76MP0000015_abnormal_ear_pigmentation0.92675277
77MP0002998_abnormal_bone_remodeling0.91394225
78MP0002653_abnormal_ependyma_morphology0.90426825
79MP0009643_abnormal_urine_homeostasis0.86676742
80MP0001666_abnormal_nutrient_absorption0.86467646
81MP0000343_altered_response_to0.85726199
82MP0003045_fibrosis0.85620414
83MP0005319_abnormal_enzyme/_coenzyme0.85563131
84MP0002006_tumorigenesis0.85511471
85MP0004381_abnormal_hair_follicle0.84404123
86MP0005365_abnormal_bile_salt0.84361660
87MP0003172_abnormal_lysosome_physiology0.84207468
88MP0009763_increased_sensitivity_to0.83836259
89MP0002136_abnormal_kidney_physiology0.76159971
90MP0008004_abnormal_stomach_pH0.75680516
91MP0005636_abnormal_mineral_homeostasis0.73957748
92MP0005164_abnormal_response_to0.73767675
93MP0003448_altered_tumor_morphology0.71819235
94MP0002933_joint_inflammation0.70537876
95MP0000249_abnormal_blood_vessel0.68798312
96MP0000609_abnormal_liver_physiology0.66802422
97MP0003828_pulmonary_edema0.65485677
98MP0005390_skeleton_phenotype0.64800816
99MP0005174_abnormal_tail_pigmentation0.62946343
100MP0000604_amyloidosis0.62418757

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.92643079
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.34321219
3Absent/shortened dynein arms (HP:0200106)5.34321219
4Myositis (HP:0100614)5.16851156
5Recurrent bacterial skin infections (HP:0005406)4.55929241
6Orchitis (HP:0100796)4.55855547
7Recurrent abscess formation (HP:0002722)4.52082308
8Optic neuritis (HP:0100653)4.38747760
9Retrobulbar optic neuritis (HP:0100654)4.38747760
10Abnormal respiratory motile cilium morphology (HP:0005938)4.38573841
11Abnormal respiratory epithelium morphology (HP:0012253)4.38573841
12Nasal polyposis (HP:0100582)4.38102469
13Abnormal ciliary motility (HP:0012262)4.24976673
14Abnormal respiratory motile cilium physiology (HP:0012261)3.99631722
15Abnormality of the nasal mucosa (HP:0000433)3.98979877
16Elevated erythrocyte sedimentation rate (HP:0003565)3.97956740
17Abnormality of macrophages (HP:0004311)3.91526640
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.84690413
19Hyperactive renin-angiotensin system (HP:0000841)3.64436774
20Encephalitis (HP:0002383)3.63721905
21Spontaneous hematomas (HP:0007420)3.58932768
22Meningitis (HP:0001287)3.45267090
23Increased IgE level (HP:0003212)3.45106621
24Obstructive lung disease (HP:0006536)3.40731974
25Chronic obstructive pulmonary disease (HP:0006510)3.40731974
26Chronic otitis media (HP:0000389)3.30669253
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.29261251
28Keratoconjunctivitis sicca (HP:0001097)3.23689401
29Bronchiectasis (HP:0002110)3.23428451
30Malnutrition (HP:0004395)3.21453356
31Recurrent sinusitis (HP:0011108)3.20737398
32Recurrent gram-negative bacterial infections (HP:0005420)3.18309651
33Pustule (HP:0200039)3.16080955
34Gastrointestinal infarctions (HP:0005244)3.09854729
35Recurrent fungal infections (HP:0002841)3.06479250
36Keratoconjunctivitis (HP:0001096)3.00974670
37Rhinitis (HP:0012384)2.99592814
38Vasculitis (HP:0002633)2.99222904
39Decreased circulating renin level (HP:0003351)2.98275056
40Petechiae (HP:0000967)2.90020971
41Mediastinal lymphadenopathy (HP:0100721)2.86635610
42Chronic bronchitis (HP:0004469)2.85732064
43Recurrent skin infections (HP:0001581)2.85383698
44Gingivitis (HP:0000230)2.78785779
45Urticaria (HP:0001025)2.77048240
46Abnormality of T cell number (HP:0011839)2.67525499
47T lymphocytopenia (HP:0005403)2.67484659
48Bronchitis (HP:0012387)2.67143517
49Inflammation of the large intestine (HP:0002037)2.66346146
50Panhypogammaglobulinemia (HP:0003139)2.59515954
51Gastrointestinal inflammation (HP:0004386)2.57515560
52Prolonged bleeding time (HP:0003010)2.57278181
53Pulmonary embolism (HP:0002204)2.55449089
54Recurrent bronchitis (HP:0002837)2.54363891
55Stomatitis (HP:0010280)2.49549885
56Hemoptysis (HP:0002105)2.49147523
57Chronic sinusitis (HP:0011109)2.48701323
58Abnormality of renin-angiotensin system (HP:0000847)2.43898040
59Chronic diarrhea (HP:0002028)2.40910563
60Pulmonary infiltrates (HP:0002113)2.40156383
61Abnormality of T cells (HP:0002843)2.34974168
62Recurrent cutaneous fungal infections (HP:0011370)2.31391898
63Chronic mucocutaneous candidiasis (HP:0002728)2.31391898
64Anorexia (HP:0002039)2.30920350
65Metabolic alkalosis (HP:0200114)2.29124599
66Granulocytopenia (HP:0001913)2.25717727
67Epistaxis (HP:0000421)2.22547281
68Agammaglobulinemia (HP:0004432)2.22350920
69Cellulitis (HP:0100658)2.20695730
70Premature loss of primary teeth (HP:0006323)2.18830170
71Chest pain (HP:0100749)2.18453083
72Recurrent viral infections (HP:0004429)2.17530942
73Arterial thrombosis (HP:0004420)2.17146543
74Hypergammaglobulinemia (HP:0010702)2.16781124
75Increased IgM level (HP:0003496)2.16044088
76Gingival bleeding (HP:0000225)2.14907565
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10891952
78Purpura (HP:0000979)2.10513379
79Leukocytosis (HP:0001974)2.08187075
80Hypochromic anemia (HP:0001931)2.07877087
81Gangrene (HP:0100758)2.03746002
82Alkalosis (HP:0001948)2.03418032
83Recurrent otitis media (HP:0000403)2.03233281
84Recurrent pneumonia (HP:0006532)2.03116677
85Eosinophilia (HP:0001880)2.02368312
86Abnormality of T cell physiology (HP:0011840)1.97991701
87Glomerulopathy (HP:0100820)1.94388924
88Acne (HP:0001061)1.93864591
89Gastrointestinal dysmotility (HP:0002579)1.93782726
90Hemorrhage of the eye (HP:0011885)1.92245843
91Abnormality of eosinophils (HP:0001879)1.89985570
92Severe visual impairment (HP:0001141)1.88869038
93Systemic lupus erythematosus (HP:0002725)1.85948689
94Microcytic anemia (HP:0001935)1.85760303
95Abnormality of chloride homeostasis (HP:0011422)1.85307583
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82724595
97Autoimmune thrombocytopenia (HP:0001973)1.80768970
98Osteomyelitis (HP:0002754)1.80671657
99Alveolar cell carcinoma (HP:0006519)1.78852350
100Abnormality of the pleura (HP:0002103)1.78592259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.46844618
2RIPK44.41445510
3IRAK42.98037810
4TXK2.91214870
5ERN12.76129597
6ZAP702.55164906
7EPHB12.54892407
8CSK2.45727314
9BLK2.40305997
10GRK62.16827566
11TNK21.93808240
12TYK21.92378777
13BTK1.87099092
14TESK21.84220657
15TBK11.83770026
16MAP2K31.79169276
17FES1.77229347
18SYK1.69317280
19ACVR1B1.68876994
20CDC42BPA1.61637394
21JAK31.58355307
22LIMK11.55069168
23MAP3K111.50078739
24TRIB31.47757546
25LYN1.42115365
26MATK1.41975641
27KIT1.40470305
28PTK61.40394955
29EPHA21.38730545
30JAK11.38719518
31HCK1.37829694
32PRPF4B1.37019505
33MAP3K31.35941491
34IKBKE1.35032598
35MST41.31542627
36ITK1.26970061
37LCK1.22292274
38MAP3K141.22015640
39CDK191.18799329
40MAPK151.17931534
41MAP3K11.16753515
42TAOK11.13892420
43KDR1.12575590
44EPHA31.12142433
45TAOK31.05836084
46PRKG21.05268368
47TEC1.04408166
48SMG11.03913725
49FGR1.02637640
50PRKD20.98407400
51PRKCQ0.98137879
52MST1R0.95870837
53BMPR20.93556883
54SIK30.91920283
55PDK10.89676735
56IRAK10.88805422
57JAK20.87518875
58MAP3K20.87099434
59PDPK10.86020302
60IKBKB0.85713941
61CSF1R0.84416248
62PIK3CA0.80594744
63MAP2K60.73724540
64FGFR30.71639174
65MAP2K20.71590620
66STK160.70622011
67MARK30.68556746
68PTK2B0.68109779
69TESK10.67223071
70FGFR40.67156322
71MAPK110.62060116
72FYN0.60779771
73MAPKAPK20.60503704
74ADRBK20.59431556
75RIPK10.58223583
76MARK20.57952717
77MAP3K130.53538151
78STK100.51886381
79KSR20.51085389
80MAP3K70.50338017
81MAP3K60.49350800
82OXSR10.45283444
83PIM10.45062212
84MAPK70.43946186
85LRRK20.43031194
86MELK0.42878000
87CAMKK20.42803026
88TLK10.41876472
89PKN20.41096997
90HIPK20.40652338
91STK240.40086490
92PRKCD0.39977559
93CLK10.39959189
94CAMKK10.36258242
95RET0.35936467
96NLK0.35865555
97MAPK120.35855041
98DYRK1B0.34042637
99SIK20.33802648
100CDK40.30156837

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.31163852
2Allograft rejection_Homo sapiens_hsa053302.93440391
3Autoimmune thyroid disease_Homo sapiens_hsa053202.75462473
4Leishmaniasis_Homo sapiens_hsa051402.64417653
5Staphylococcus aureus infection_Homo sapiens_hsa051502.46678759
6Primary immunodeficiency_Homo sapiens_hsa053402.33330272
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.31642504
8Antigen processing and presentation_Homo sapiens_hsa046122.22652467
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19679680
10Type I diabetes mellitus_Homo sapiens_hsa049402.19262137
11Sulfur metabolism_Homo sapiens_hsa009202.17398932
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.13057308
13Asthma_Homo sapiens_hsa053102.00571682
14Osteoclast differentiation_Homo sapiens_hsa043801.94310957
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88452035
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71228350
17B cell receptor signaling pathway_Homo sapiens_hsa046621.68261191
18Hematopoietic cell lineage_Homo sapiens_hsa046401.65192583
19Tuberculosis_Homo sapiens_hsa051521.63376779
20Viral myocarditis_Homo sapiens_hsa054161.56602903
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.51358681
22Arachidonic acid metabolism_Homo sapiens_hsa005901.40836033
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.40277929
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36874029
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33971703
26Linoleic acid metabolism_Homo sapiens_hsa005911.33536431
27Histidine metabolism_Homo sapiens_hsa003401.33231630
28Fat digestion and absorption_Homo sapiens_hsa049751.31760083
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25828893
30Measles_Homo sapiens_hsa051621.23411314
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22876138
32T cell receptor signaling pathway_Homo sapiens_hsa046601.20846726
33Toxoplasmosis_Homo sapiens_hsa051451.20171859
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.18785873
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18218615
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16318731
37Chemokine signaling pathway_Homo sapiens_hsa040621.15573077
38Influenza A_Homo sapiens_hsa051641.15294401
39Other glycan degradation_Homo sapiens_hsa005111.14317893
40Malaria_Homo sapiens_hsa051441.13332863
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13194788
42Chemical carcinogenesis_Homo sapiens_hsa052041.10682586
43Legionellosis_Homo sapiens_hsa051341.09597396
44Herpes simplex infection_Homo sapiens_hsa051681.04822645
45Hepatitis C_Homo sapiens_hsa051601.04043652
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99426353
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98208676
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96817107
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.96338357
50Caffeine metabolism_Homo sapiens_hsa002320.93855610
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86570648
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.86402438
53Platelet activation_Homo sapiens_hsa046110.86070790
54Pertussis_Homo sapiens_hsa051330.84849113
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84021864
56Acute myeloid leukemia_Homo sapiens_hsa052210.82826654
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82352452
58African trypanosomiasis_Homo sapiens_hsa051430.81709002
59Rheumatoid arthritis_Homo sapiens_hsa053230.80073452
60Phagosome_Homo sapiens_hsa041450.76982110
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76017617
62Renin-angiotensin system_Homo sapiens_hsa046140.75962248
63Mineral absorption_Homo sapiens_hsa049780.75695878
64Retinol metabolism_Homo sapiens_hsa008300.74591632
65Nitrogen metabolism_Homo sapiens_hsa009100.74333658
66Vitamin digestion and absorption_Homo sapiens_hsa049770.73232662
67Pancreatic secretion_Homo sapiens_hsa049720.72655146
68Starch and sucrose metabolism_Homo sapiens_hsa005000.72030742
69TNF signaling pathway_Homo sapiens_hsa046680.71691338
70Shigellosis_Homo sapiens_hsa051310.71658204
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67476999
72Apoptosis_Homo sapiens_hsa042100.66004907
73Ether lipid metabolism_Homo sapiens_hsa005650.64733300
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.64574336
75Phenylalanine metabolism_Homo sapiens_hsa003600.63510066
76Salmonella infection_Homo sapiens_hsa051320.63376215
77Sulfur relay system_Homo sapiens_hsa041220.59981833
78Glycerolipid metabolism_Homo sapiens_hsa005610.59461041
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56437075
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.56433138
81Endocytosis_Homo sapiens_hsa041440.52556488
82Fructose and mannose metabolism_Homo sapiens_hsa000510.51478762
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47467986
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46847033
85VEGF signaling pathway_Homo sapiens_hsa043700.46498659
86PPAR signaling pathway_Homo sapiens_hsa033200.44829740
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.44772136
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44117024
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43419162
90Non-small cell lung cancer_Homo sapiens_hsa052230.43186545
91Lysosome_Homo sapiens_hsa041420.42751782
92Pancreatic cancer_Homo sapiens_hsa052120.41739700
93Hepatitis B_Homo sapiens_hsa051610.39358338
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39010589
95Fatty acid degradation_Homo sapiens_hsa000710.38219677
96Bile secretion_Homo sapiens_hsa049760.37868519
97Tyrosine metabolism_Homo sapiens_hsa003500.37681093
98Sphingolipid metabolism_Homo sapiens_hsa006000.37162657
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.36304001
100Regulation of autophagy_Homo sapiens_hsa041400.35185150

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »