

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mature B cell differentiation involved in immune response (GO:0002313) | 6.62746171 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.18190671 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.22273735 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.22273735 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.13238461 |
| 6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.90099596 |
| 7 | platelet dense granule organization (GO:0060155) | 4.69811467 |
| 8 | respiratory electron transport chain (GO:0022904) | 4.65990598 |
| 9 | protein neddylation (GO:0045116) | 4.62249787 |
| 10 | electron transport chain (GO:0022900) | 4.57431031 |
| 11 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 4.56779887 |
| 12 | deoxyribose phosphate biosynthetic process (GO:0046385) | 4.56779887 |
| 13 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 4.54434247 |
| 14 | phagocytosis, engulfment (GO:0006911) | 4.51873089 |
| 15 | mature B cell differentiation (GO:0002335) | 4.51748106 |
| 16 | viral transcription (GO:0019083) | 4.48976817 |
| 17 | anterograde synaptic vesicle transport (GO:0048490) | 4.34362201 |
| 18 | ribosomal small subunit assembly (GO:0000028) | 4.27546275 |
| 19 | proteasome assembly (GO:0043248) | 4.23103486 |
| 20 | translational termination (GO:0006415) | 4.18212085 |
| 21 | positive regulation of interleukin-8 secretion (GO:2000484) | 4.04764050 |
| 22 | cGMP biosynthetic process (GO:0006182) | 4.01898736 |
| 23 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.98816008 |
| 24 | translational elongation (GO:0006414) | 3.96208611 |
| 25 | cotranslational protein targeting to membrane (GO:0006613) | 3.95032464 |
| 26 | protein targeting to ER (GO:0045047) | 3.93002448 |
| 27 | mannosylation (GO:0097502) | 3.89356858 |
| 28 | immunoglobulin mediated immune response (GO:0016064) | 3.87649462 |
| 29 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.82947750 |
| 30 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.78560348 |
| 31 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.77468555 |
| 32 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.69054181 |
| 33 | positive regulation of mast cell degranulation (GO:0043306) | 3.69054181 |
| 34 | ribosomal large subunit biogenesis (GO:0042273) | 3.69009167 |
| 35 | protein localization to endoplasmic reticulum (GO:0070972) | 3.67677866 |
| 36 | actin nucleation (GO:0045010) | 3.65869049 |
| 37 | maturation of SSU-rRNA (GO:0030490) | 3.56896090 |
| 38 | positive regulation of mast cell activation (GO:0033005) | 3.53585926 |
| 39 | purine nucleotide salvage (GO:0032261) | 3.51079569 |
| 40 | oxidative phosphorylation (GO:0006119) | 3.49931331 |
| 41 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.45916455 |
| 42 | DNA deamination (GO:0045006) | 3.44558047 |
| 43 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.42710191 |
| 44 | adenosine metabolic process (GO:0046085) | 3.39302856 |
| 45 | cytidine metabolic process (GO:0046087) | 3.35926277 |
| 46 | cytidine catabolic process (GO:0006216) | 3.35926277 |
| 47 | cytidine deamination (GO:0009972) | 3.35926277 |
| 48 | aerobic respiration (GO:0009060) | 3.32418117 |
| 49 | B cell mediated immunity (GO:0019724) | 3.28077763 |
| 50 | mast cell activation (GO:0045576) | 3.27626911 |
| 51 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.27204502 |
| 52 | neutrophil activation involved in immune response (GO:0002283) | 3.24135954 |
| 53 | one-carbon compound transport (GO:0019755) | 3.24128043 |
| 54 | regulation of interleukin-8 secretion (GO:2000482) | 3.23519480 |
| 55 | viral life cycle (GO:0019058) | 3.20123365 |
| 56 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.16243995 |
| 57 | membrane invagination (GO:0010324) | 3.11016044 |
| 58 | deoxyribose phosphate metabolic process (GO:0019692) | 3.07455606 |
| 59 | execution phase of apoptosis (GO:0097194) | 3.05211081 |
| 60 | cellular protein complex disassembly (GO:0043624) | 2.99656127 |
| 61 | AMP metabolic process (GO:0046033) | 2.99057961 |
| 62 | protein complex biogenesis (GO:0070271) | 2.99050536 |
| 63 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.94871552 |
| 64 | translational initiation (GO:0006413) | 2.94385315 |
| 65 | purine-containing compound salvage (GO:0043101) | 2.92972347 |
| 66 | regulation of hypersensitivity (GO:0002883) | 2.92894215 |
| 67 | response to interferon-beta (GO:0035456) | 2.90846961 |
| 68 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.90197829 |
| 69 | deoxyribose phosphate catabolic process (GO:0046386) | 2.89491712 |
| 70 | cGMP metabolic process (GO:0046068) | 2.81803871 |
| 71 | hydrogen ion transmembrane transport (GO:1902600) | 2.80625006 |
| 72 | organelle disassembly (GO:1903008) | 2.78207849 |
| 73 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.78142859 |
| 74 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.76764107 |
| 75 | protein targeting to membrane (GO:0006612) | 2.75872812 |
| 76 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.71366869 |
| 77 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.70736816 |
| 78 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.70446748 |
| 79 | regulation of protein polyubiquitination (GO:1902914) | 2.68004229 |
| 80 | cellular response to interferon-gamma (GO:0071346) | 2.67782363 |
| 81 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.67263873 |
| 82 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.64704233 |
| 83 | regulation of cytokine secretion involved in immune response (GO:0002739) | 2.63791477 |
| 84 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.63420193 |
| 85 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.63410773 |
| 86 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.63293391 |
| 87 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.63293391 |
| 88 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.63085549 |
| 89 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.63085549 |
| 90 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.63085549 |
| 91 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 2.61684197 |
| 92 | regulation of regulatory T cell differentiation (GO:0045589) | 2.60946536 |
| 93 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 2.60241546 |
| 94 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.59655122 |
| 95 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.58613991 |
| 96 | proton transport (GO:0015992) | 2.58008096 |
| 97 | translation (GO:0006412) | 2.57919817 |
| 98 | detection of bacterium (GO:0016045) | 2.57407011 |
| 99 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 2.56673495 |
| 100 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 2.56673495 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 6.85802256 |
| 2 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.77099918 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.59229959 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.51544437 |
| 5 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.51425791 |
| 6 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.44562685 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.38997211 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.20780883 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.11167482 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.51013275 |
| 11 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.48369660 |
| 12 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.39700170 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.26899878 |
| 14 | EWS_26573619_Chip-Seq_HEK293_Human | 2.24375237 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.09709206 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.09307603 |
| 17 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.07875122 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.05253381 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.90405299 |
| 20 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.88515509 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 1.87763674 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.80832340 |
| 23 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.78776149 |
| 24 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.70917425 |
| 25 | GATA3_26560356_Chip-Seq_TH2_Human | 1.68360812 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.65407393 |
| 27 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.64763583 |
| 28 | MYB_26560356_Chip-Seq_TH2_Human | 1.64298245 |
| 29 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.64258166 |
| 30 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.54115354 |
| 31 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.52936941 |
| 32 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.46761597 |
| 33 | AR_20517297_ChIP-Seq_VCAP_Human | 1.43552236 |
| 34 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.43143673 |
| 35 | FUS_26573619_Chip-Seq_HEK293_Human | 1.42784333 |
| 36 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.42251136 |
| 37 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.39238560 |
| 38 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.39238560 |
| 39 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.38067468 |
| 40 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.36212296 |
| 41 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.33874273 |
| 42 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.33006467 |
| 43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.32668868 |
| 44 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.32276566 |
| 45 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.31145592 |
| 46 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.31145592 |
| 47 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.29833572 |
| 48 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.29382744 |
| 49 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.26231998 |
| 50 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25884175 |
| 51 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.25409640 |
| 52 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.20977760 |
| 53 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.20576176 |
| 54 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.19242823 |
| 55 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.18312788 |
| 56 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.17318995 |
| 57 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.15161449 |
| 58 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.14667311 |
| 59 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.13647886 |
| 60 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.12161431 |
| 61 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.11984936 |
| 62 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.11972552 |
| 63 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.11758904 |
| 64 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.10406885 |
| 65 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.09858363 |
| 66 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.09763917 |
| 67 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.09626788 |
| 68 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.08113431 |
| 69 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.07101957 |
| 70 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.07065702 |
| 71 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.06679195 |
| 72 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.06679195 |
| 73 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.06251282 |
| 74 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.06166133 |
| 75 | P300_19829295_ChIP-Seq_ESCs_Human | 1.06001352 |
| 76 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05549315 |
| 77 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.03943235 |
| 78 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.03385320 |
| 79 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00755476 |
| 80 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.99309544 |
| 81 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.98811843 |
| 82 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98751264 |
| 83 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.96922162 |
| 84 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.96177587 |
| 85 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.94515111 |
| 86 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.93209699 |
| 87 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.92952951 |
| 88 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90616684 |
| 89 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.90488393 |
| 90 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.90383460 |
| 91 | NCOR_22424771_ChIP-Seq_293T_Human | 0.90148065 |
| 92 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.89998910 |
| 93 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.89518919 |
| 94 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.88112612 |
| 95 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.87833094 |
| 96 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.87502800 |
| 97 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.86753896 |
| 98 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86682391 |
| 99 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.86682391 |
| 100 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.86319566 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 4.88704910 |
| 2 | MP0001835_abnormal_antigen_presentation | 4.32703481 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 4.25306956 |
| 4 | MP0000569_abnormal_digit_pigmentation | 4.13303565 |
| 5 | MP0005671_abnormal_response_to | 3.69062846 |
| 6 | MP0002166_altered_tumor_susceptibility | 3.16357273 |
| 7 | MP0000516_abnormal_urinary_system | 2.59867084 |
| 8 | MP0005367_renal/urinary_system_phenotyp | 2.59867084 |
| 9 | MP0001529_abnormal_vocalization | 2.58593110 |
| 10 | MP0002006_tumorigenesis | 2.42825105 |
| 11 | MP0002132_abnormal_respiratory_system | 2.36736095 |
| 12 | MP0004147_increased_porphyrin_level | 2.33915538 |
| 13 | MP0009785_altered_susceptibility_to | 2.32334673 |
| 14 | MP0000372_irregular_coat_pigmentation | 2.14047217 |
| 15 | MP0005408_hypopigmentation | 2.02876470 |
| 16 | MP0009764_decreased_sensitivity_to | 1.99359082 |
| 17 | MP0001800_abnormal_humoral_immune | 1.98213213 |
| 18 | MP0005075_abnormal_melanosome_morpholog | 1.95248743 |
| 19 | MP0005645_abnormal_hypothalamus_physiol | 1.94345627 |
| 20 | MP0002138_abnormal_hepatobiliary_system | 1.91382463 |
| 21 | MP0005464_abnormal_platelet_physiology | 1.78981631 |
| 22 | MP0005670_abnormal_white_adipose | 1.75899520 |
| 23 | MP0002148_abnormal_hypersensitivity_rea | 1.74859644 |
| 24 | MP0005000_abnormal_immune_tolerance | 1.71591435 |
| 25 | MP0005174_abnormal_tail_pigmentation | 1.71427758 |
| 26 | MP0004142_abnormal_muscle_tone | 1.68138837 |
| 27 | MP0003252_abnormal_bile_duct | 1.62467228 |
| 28 | MP0002723_abnormal_immune_serum | 1.61935199 |
| 29 | MP0010155_abnormal_intestine_physiology | 1.58475869 |
| 30 | MP0000015_abnormal_ear_pigmentation | 1.56843216 |
| 31 | MP0002452_abnormal_antigen_presenting | 1.55530324 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.53738857 |
| 33 | MP0005025_abnormal_response_to | 1.52206891 |
| 34 | MP0002822_catalepsy | 1.50384391 |
| 35 | MP0002277_abnormal_respiratory_mucosa | 1.45079455 |
| 36 | MP0002420_abnormal_adaptive_immunity | 1.41846780 |
| 37 | MP0003724_increased_susceptibility_to | 1.40753658 |
| 38 | MP0001819_abnormal_immune_cell | 1.37679662 |
| 39 | MP0003011_delayed_dark_adaptation | 1.36558434 |
| 40 | MP0009697_abnormal_copulation | 1.29103590 |
| 41 | MP0003075_altered_response_to | 1.27533753 |
| 42 | MP0001764_abnormal_homeostasis | 1.25704535 |
| 43 | MP0003866_abnormal_defecation | 1.21502551 |
| 44 | MP0005646_abnormal_pituitary_gland | 1.20507856 |
| 45 | MP0002398_abnormal_bone_marrow | 1.18616236 |
| 46 | MP0005535_abnormal_body_temperature | 1.18392994 |
| 47 | MP0001873_stomach_inflammation | 1.18024628 |
| 48 | MP0000716_abnormal_immune_system | 1.16267676 |
| 49 | MP0002419_abnormal_innate_immunity | 1.15422604 |
| 50 | MP0001790_abnormal_immune_system | 1.12001836 |
| 51 | MP0005387_immune_system_phenotype | 1.12001836 |
| 52 | MP0002095_abnormal_skin_pigmentation | 1.10351654 |
| 53 | MP0008961_abnormal_basal_metabolism | 1.10047201 |
| 54 | MP0001853_heart_inflammation | 1.08830012 |
| 55 | MP0003191_abnormal_cellular_cholesterol | 1.08746392 |
| 56 | MP0003283_abnormal_digestive_organ | 1.05294427 |
| 57 | MP0001486_abnormal_startle_reflex | 1.02767688 |
| 58 | MP0003303_peritoneal_inflammation | 1.01683702 |
| 59 | MP0004808_abnormal_hematopoietic_stem | 0.99380313 |
| 60 | MP0008469_abnormal_protein_level | 0.99357002 |
| 61 | MP0002090_abnormal_vision | 0.98269451 |
| 62 | MP0004134_abnormal_chest_morphology | 0.98102674 |
| 63 | MP0006036_abnormal_mitochondrial_physio | 0.97785063 |
| 64 | MP0003763_abnormal_thymus_physiology | 0.97651797 |
| 65 | MP0000685_abnormal_immune_system | 0.97363624 |
| 66 | MP0005409_darkened_coat_color | 0.95090166 |
| 67 | MP0002837_dystrophic_cardiac_calcinosis | 0.91994827 |
| 68 | MP0001845_abnormal_inflammatory_respons | 0.89795464 |
| 69 | MP0002928_abnormal_bile_duct | 0.89192482 |
| 70 | MP0002429_abnormal_blood_cell | 0.88397747 |
| 71 | MP0005166_decreased_susceptibility_to | 0.88348291 |
| 72 | MP0005085_abnormal_gallbladder_physiolo | 0.87584456 |
| 73 | MP0002234_abnormal_pharynx_morphology | 0.85719981 |
| 74 | MP0009763_increased_sensitivity_to | 0.85173783 |
| 75 | MP0000343_altered_response_to | 0.82435463 |
| 76 | MP0004924_abnormal_behavior | 0.80322342 |
| 77 | MP0005386_behavior/neurological_phenoty | 0.80322342 |
| 78 | MP0008877_abnormal_DNA_methylation | 0.77790148 |
| 79 | MP0001324_abnormal_eye_pigmentation | 0.76803246 |
| 80 | MP0000566_synostosis | 0.76150748 |
| 81 | MP0000689_abnormal_spleen_morphology | 0.72884741 |
| 82 | MP0003136_yellow_coat_color | 0.72072993 |
| 83 | MP0004145_abnormal_muscle_electrophysio | 0.71152025 |
| 84 | MP0000703_abnormal_thymus_morphology | 0.69925487 |
| 85 | MP0001501_abnormal_sleep_pattern | 0.69826286 |
| 86 | MP0003646_muscle_fatigue | 0.69311379 |
| 87 | MP0006072_abnormal_retinal_apoptosis | 0.68084986 |
| 88 | MP0002722_abnormal_immune_system | 0.67871676 |
| 89 | MP0002396_abnormal_hematopoietic_system | 0.67819803 |
| 90 | MP0005551_abnormal_eye_electrophysiolog | 0.67747788 |
| 91 | MP0001177_atelectasis | 0.67543649 |
| 92 | MP0001440_abnormal_grooming_behavior | 0.67468879 |
| 93 | MP0001905_abnormal_dopamine_level | 0.66717930 |
| 94 | MP0001191_abnormal_skin_condition | 0.65249414 |
| 95 | MP0008873_increased_physiological_sensi | 0.63579340 |
| 96 | MP0003880_abnormal_central_pattern | 0.62757035 |
| 97 | MP0002405_respiratory_system_inflammati | 0.62213792 |
| 98 | MP0002272_abnormal_nervous_system | 0.61523415 |
| 99 | MP0001663_abnormal_digestive_system | 0.61431607 |
| 100 | MP0002938_white_spotting | 0.58040912 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Type I transferrin isoform profile (HP:0003642) | 6.07492973 |
| 2 | Increased hepatocellular lipid droplets (HP:0006565) | 4.38018168 |
| 3 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 4.37371035 |
| 4 | Abnormal protein N-linked glycosylation (HP:0012347) | 4.37371035 |
| 5 | Abnormal protein glycosylation (HP:0012346) | 4.37371035 |
| 6 | Abnormal glycosylation (HP:0012345) | 4.37371035 |
| 7 | Mitochondrial inheritance (HP:0001427) | 4.33232644 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 4.27926277 |
| 9 | Hepatocellular necrosis (HP:0001404) | 4.16901605 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 4.15783656 |
| 11 | Congenital, generalized hypertrichosis (HP:0004540) | 3.93295789 |
| 12 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.86899674 |
| 13 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.82088874 |
| 14 | Exertional dyspnea (HP:0002875) | 3.76724204 |
| 15 | Increased IgM level (HP:0003496) | 3.70841422 |
| 16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.68794490 |
| 17 | Hepatic necrosis (HP:0002605) | 3.66039723 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 3.56267434 |
| 19 | Progressive macrocephaly (HP:0004481) | 3.53569146 |
| 20 | Reduced antithrombin III activity (HP:0001976) | 3.47006906 |
| 21 | Dry hair (HP:0011359) | 3.44892472 |
| 22 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.43936376 |
| 23 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.43936376 |
| 24 | Increased CSF lactate (HP:0002490) | 3.32659222 |
| 25 | Renal Fanconi syndrome (HP:0001994) | 3.21200709 |
| 26 | Acute encephalopathy (HP:0006846) | 3.19431096 |
| 27 | Fair hair (HP:0002286) | 3.14085573 |
| 28 | Metaphyseal dysplasia (HP:0100255) | 3.03290165 |
| 29 | Respiratory difficulties (HP:0002880) | 2.98684390 |
| 30 | Increased intramyocellular lipid droplets (HP:0012240) | 2.96549183 |
| 31 | Hypoproteinemia (HP:0003075) | 2.89183016 |
| 32 | Abnormality of renal resorption (HP:0011038) | 2.72866968 |
| 33 | Cerebral edema (HP:0002181) | 2.72280800 |
| 34 | Abnormality of B cell number (HP:0010975) | 2.71846872 |
| 35 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.63428650 |
| 36 | Abnormal biliary tract physiology (HP:0012439) | 2.60348176 |
| 37 | Bile duct proliferation (HP:0001408) | 2.60348176 |
| 38 | Increased muscle lipid content (HP:0009058) | 2.58616291 |
| 39 | Petechiae (HP:0000967) | 2.58246350 |
| 40 | Abnormality of T cell number (HP:0011839) | 2.50151031 |
| 41 | Delayed CNS myelination (HP:0002188) | 2.46676225 |
| 42 | T lymphocytopenia (HP:0005403) | 2.45727111 |
| 43 | Generalized hypopigmentation of hair (HP:0011358) | 2.45232504 |
| 44 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.42098659 |
| 45 | Azoospermia (HP:0000027) | 2.41902800 |
| 46 | Pancreatic fibrosis (HP:0100732) | 2.31257303 |
| 47 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.28762238 |
| 48 | Aplastic anemia (HP:0001915) | 2.28231206 |
| 49 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.26644878 |
| 50 | Absent/shortened dynein arms (HP:0200106) | 2.26644878 |
| 51 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.21466760 |
| 52 | Leukodystrophy (HP:0002415) | 2.18724848 |
| 53 | Macrocytic anemia (HP:0001972) | 2.17880434 |
| 54 | B lymphocytopenia (HP:0010976) | 2.15334256 |
| 55 | Dicarboxylic aciduria (HP:0003215) | 2.14548475 |
| 56 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.14548475 |
| 57 | Concave nail (HP:0001598) | 2.11456524 |
| 58 | Abnormality of secondary sexual hair (HP:0009888) | 2.10582225 |
| 59 | Abnormality of the axillary hair (HP:0100134) | 2.10582225 |
| 60 | Lower limb hyperreflexia (HP:0002395) | 2.10222085 |
| 61 | Pancreatic cysts (HP:0001737) | 2.10077367 |
| 62 | Hypoplasia of the thymus (HP:0000778) | 2.09457289 |
| 63 | Ridged nail (HP:0001807) | 1.99840684 |
| 64 | Amyotrophic lateral sclerosis (HP:0007354) | 1.99248201 |
| 65 | Cerebral hemorrhage (HP:0001342) | 1.98694099 |
| 66 | Hyperventilation (HP:0002883) | 1.97352511 |
| 67 | Recurrent bacterial skin infections (HP:0005406) | 1.97252915 |
| 68 | Type II lissencephaly (HP:0007260) | 1.96945919 |
| 69 | Increased serum lactate (HP:0002151) | 1.95078794 |
| 70 | Pustule (HP:0200039) | 1.90970512 |
| 71 | Agammaglobulinemia (HP:0004432) | 1.89563894 |
| 72 | Progressive microcephaly (HP:0000253) | 1.89108751 |
| 73 | Respiratory failure (HP:0002878) | 1.87439419 |
| 74 | Recurrent abscess formation (HP:0002722) | 1.87115350 |
| 75 | Absence seizures (HP:0002121) | 1.86700918 |
| 76 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.84542633 |
| 77 | Abnormality of T cells (HP:0002843) | 1.84259846 |
| 78 | Lactic acidosis (HP:0003128) | 1.83569850 |
| 79 | Rimmed vacuoles (HP:0003805) | 1.83483533 |
| 80 | Albinism (HP:0001022) | 1.82521606 |
| 81 | Panhypogammaglobulinemia (HP:0003139) | 1.81776105 |
| 82 | Optic disc pallor (HP:0000543) | 1.81526908 |
| 83 | Agitation (HP:0000713) | 1.76635395 |
| 84 | Cerebellar dysplasia (HP:0007033) | 1.75715346 |
| 85 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.74439711 |
| 86 | Abnormality of lateral ventricle (HP:0030047) | 1.68568577 |
| 87 | Severe combined immunodeficiency (HP:0004430) | 1.68433007 |
| 88 | Focal motor seizures (HP:0011153) | 1.67164963 |
| 89 | Recurrent cutaneous fungal infections (HP:0011370) | 1.66762478 |
| 90 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.66762478 |
| 91 | Lethargy (HP:0001254) | 1.66131413 |
| 92 | Abnormality of midbrain morphology (HP:0002418) | 1.65535802 |
| 93 | Molar tooth sign on MRI (HP:0002419) | 1.65535802 |
| 94 | Median cleft lip (HP:0000161) | 1.64895941 |
| 95 | Atrioventricular block (HP:0001678) | 1.64701946 |
| 96 | Hyperphosphaturia (HP:0003109) | 1.62517686 |
| 97 | Muscle fiber atrophy (HP:0100295) | 1.62482376 |
| 98 | Encephalitis (HP:0002383) | 1.62282569 |
| 99 | Hypothermia (HP:0002045) | 1.61103906 |
| 100 | Myokymia (HP:0002411) | 1.60936412 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K12 | 5.37640324 |
| 2 | MAP4K2 | 4.21995249 |
| 3 | BMPR2 | 4.07591555 |
| 4 | ZAK | 3.51101309 |
| 5 | TLK1 | 3.39836850 |
| 6 | VRK2 | 3.29429289 |
| 7 | CDC7 | 3.15637362 |
| 8 | TAOK3 | 2.64035583 |
| 9 | CDK19 | 2.35424199 |
| 10 | KDR | 2.33401329 |
| 11 | MYLK | 2.21979038 |
| 12 | MST4 | 2.00116555 |
| 13 | VRK1 | 1.91870162 |
| 14 | BLK | 1.83171463 |
| 15 | WNK4 | 1.71182142 |
| 16 | SCYL2 | 1.68600428 |
| 17 | TEC | 1.65203728 |
| 18 | TYRO3 | 1.61340258 |
| 19 | KIT | 1.60422703 |
| 20 | ERBB3 | 1.53090686 |
| 21 | CSF1R | 1.49156317 |
| 22 | PIK3CG | 1.47763310 |
| 23 | STK24 | 1.43791417 |
| 24 | IKBKB | 1.38951785 |
| 25 | ILK | 1.34351984 |
| 26 | SYK | 1.33528095 |
| 27 | ADRBK2 | 1.30433004 |
| 28 | DAPK3 | 1.24736196 |
| 29 | TESK2 | 1.23831089 |
| 30 | TXK | 1.18020765 |
| 31 | DAPK1 | 1.15489331 |
| 32 | OXSR1 | 1.09410802 |
| 33 | CDK8 | 1.05830707 |
| 34 | ITK | 1.04387434 |
| 35 | MAP3K3 | 0.96478589 |
| 36 | BCKDK | 0.96231492 |
| 37 | BRSK2 | 0.94566920 |
| 38 | HCK | 0.93187349 |
| 39 | GRK6 | 0.92597011 |
| 40 | MAP3K14 | 0.91301832 |
| 41 | TNIK | 0.91053186 |
| 42 | BTK | 0.88418166 |
| 43 | STK38L | 0.87645943 |
| 44 | LYN | 0.87208755 |
| 45 | MAP2K3 | 0.85914093 |
| 46 | FRK | 0.85070278 |
| 47 | CHUK | 0.83454665 |
| 48 | FES | 0.81541538 |
| 49 | ZAP70 | 0.80888479 |
| 50 | NUAK1 | 0.76748795 |
| 51 | TAF1 | 0.72705730 |
| 52 | RIPK4 | 0.71193688 |
| 53 | MAP4K1 | 0.69876236 |
| 54 | MATK | 0.66388593 |
| 55 | AURKB | 0.64721623 |
| 56 | INSRR | 0.64641691 |
| 57 | BMPR1B | 0.61240379 |
| 58 | GRK1 | 0.58718798 |
| 59 | TYK2 | 0.58308400 |
| 60 | NME1 | 0.58142855 |
| 61 | SRPK1 | 0.57478138 |
| 62 | LCK | 0.57252197 |
| 63 | PINK1 | 0.56978839 |
| 64 | IGF1R | 0.54678977 |
| 65 | PKN1 | 0.54483730 |
| 66 | TAOK2 | 0.52223604 |
| 67 | OBSCN | 0.51939128 |
| 68 | STK39 | 0.51408516 |
| 69 | CSNK2A2 | 0.51272071 |
| 70 | EIF2AK2 | 0.49325145 |
| 71 | DAPK2 | 0.49208578 |
| 72 | ROCK1 | 0.47458164 |
| 73 | CSK | 0.46677308 |
| 74 | ATR | 0.44990532 |
| 75 | STK3 | 0.44474707 |
| 76 | AKT2 | 0.43141965 |
| 77 | PRKCQ | 0.41846093 |
| 78 | JAK3 | 0.40538587 |
| 79 | PRKG1 | 0.40517124 |
| 80 | IKBKE | 0.40073066 |
| 81 | TRPM7 | 0.40061715 |
| 82 | FYN | 0.36905452 |
| 83 | CCNB1 | 0.36363420 |
| 84 | RPS6KA5 | 0.35219328 |
| 85 | NME2 | 0.34988075 |
| 86 | PRKCD | 0.33418338 |
| 87 | CDK3 | 0.32885727 |
| 88 | ADRBK1 | 0.31199602 |
| 89 | MUSK | 0.30063897 |
| 90 | CDK14 | 0.28704090 |
| 91 | PRKCE | 0.27591834 |
| 92 | PRKACA | 0.27551255 |
| 93 | CSNK2A1 | 0.27225257 |
| 94 | TIE1 | 0.26603666 |
| 95 | MET | 0.26396598 |
| 96 | PRKCA | 0.25536753 |
| 97 | PAK1 | 0.25419191 |
| 98 | PIM1 | 0.25205842 |
| 99 | ABL1 | 0.24112071 |
| 100 | EGFR | 0.23945367 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Asthma_Homo sapiens_hsa05310 | 4.95084034 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.72685216 |
| 3 | Allograft rejection_Homo sapiens_hsa05330 | 3.72571354 |
| 4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.57429891 |
| 5 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.55544263 |
| 6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.42054804 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 3.26965798 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 3.14732214 |
| 9 | Ribosome_Homo sapiens_hsa03010 | 3.11398316 |
| 10 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.91656401 |
| 11 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.54983468 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.23520435 |
| 13 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.21609790 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 2.19521950 |
| 15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.02487082 |
| 16 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.98190956 |
| 17 | Protein export_Homo sapiens_hsa03060 | 1.91605592 |
| 18 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.79467632 |
| 19 | Leishmaniasis_Homo sapiens_hsa05140 | 1.74968717 |
| 20 | Viral myocarditis_Homo sapiens_hsa05416 | 1.71611438 |
| 21 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.69983498 |
| 22 | RNA polymerase_Homo sapiens_hsa03020 | 1.46951984 |
| 23 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.45534148 |
| 24 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.45416579 |
| 25 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.39919440 |
| 26 | Homologous recombination_Homo sapiens_hsa03440 | 1.37900889 |
| 27 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.32704104 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.29579663 |
| 29 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.17702940 |
| 30 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.08511030 |
| 31 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.02436278 |
| 32 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.01496227 |
| 33 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.98942100 |
| 34 | RNA degradation_Homo sapiens_hsa03018 | 0.87603231 |
| 35 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.86327760 |
| 36 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.82394957 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 0.80367083 |
| 38 | Tuberculosis_Homo sapiens_hsa05152 | 0.80093395 |
| 39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.76906800 |
| 40 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.76465830 |
| 41 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.75155675 |
| 42 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.73894210 |
| 43 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.72729032 |
| 44 | Spliceosome_Homo sapiens_hsa03040 | 0.71984936 |
| 45 | Legionellosis_Homo sapiens_hsa05134 | 0.68376409 |
| 46 | Phagosome_Homo sapiens_hsa04145 | 0.68118239 |
| 47 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.65368451 |
| 48 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.63213719 |
| 49 | Olfactory transduction_Homo sapiens_hsa04740 | 0.61922680 |
| 50 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.60555331 |
| 51 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.58708393 |
| 52 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.58669146 |
| 53 | Salmonella infection_Homo sapiens_hsa05132 | 0.56595171 |
| 54 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.55324157 |
| 55 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.55185236 |
| 56 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.54855894 |
| 57 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.54745724 |
| 58 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.54298019 |
| 59 | Phototransduction_Homo sapiens_hsa04744 | 0.53362195 |
| 60 | Influenza A_Homo sapiens_hsa05164 | 0.51438097 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.50276903 |
| 62 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.49339386 |
| 63 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.48878341 |
| 64 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.45832754 |
| 65 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.44244237 |
| 66 | Mismatch repair_Homo sapiens_hsa03430 | 0.44237656 |
| 67 | Platelet activation_Homo sapiens_hsa04611 | 0.42303220 |
| 68 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.41732207 |
| 69 | Peroxisome_Homo sapiens_hsa04146 | 0.39445430 |
| 70 | Pertussis_Homo sapiens_hsa05133 | 0.38489938 |
| 71 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.38023960 |
| 72 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.37287054 |
| 73 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.35666972 |
| 74 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.34135715 |
| 75 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.33058597 |
| 76 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.32102195 |
| 77 | Shigellosis_Homo sapiens_hsa05131 | 0.31791418 |
| 78 | Circadian entrainment_Homo sapiens_hsa04713 | 0.30589851 |
| 79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.30277072 |
| 80 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.28295447 |
| 81 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.27838785 |
| 82 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.27304391 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26580538 |
| 84 | Salivary secretion_Homo sapiens_hsa04970 | 0.26176061 |
| 85 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.25502915 |
| 86 | Renin secretion_Homo sapiens_hsa04924 | 0.24514065 |
| 87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.23278855 |
| 88 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.20942478 |
| 89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.19619928 |
| 90 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.19596133 |
| 91 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.18820826 |
| 92 | DNA replication_Homo sapiens_hsa03030 | 0.18353252 |
| 93 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.17588804 |
| 94 | Alcoholism_Homo sapiens_hsa05034 | 0.17278402 |
| 95 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.17102731 |
| 96 | Nicotine addiction_Homo sapiens_hsa05033 | 0.16676599 |
| 97 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.15377416 |
| 98 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.15363977 |
| 99 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.14364985 |
| 100 | Taste transduction_Homo sapiens_hsa04742 | 0.13723155 |

