LGALS9DP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mature B cell differentiation involved in immune response (GO:0002313)6.62746171
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.18190671
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22273735
4ATP synthesis coupled proton transport (GO:0015986)5.22273735
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.13238461
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.90099596
7platelet dense granule organization (GO:0060155)4.69811467
8respiratory electron transport chain (GO:0022904)4.65990598
9protein neddylation (GO:0045116)4.62249787
10electron transport chain (GO:0022900)4.57431031
112-deoxyribonucleotide biosynthetic process (GO:0009265)4.56779887
12deoxyribose phosphate biosynthetic process (GO:0046385)4.56779887
13Arp2/3 complex-mediated actin nucleation (GO:0034314)4.54434247
14phagocytosis, engulfment (GO:0006911)4.51873089
15mature B cell differentiation (GO:0002335)4.51748106
16viral transcription (GO:0019083)4.48976817
17anterograde synaptic vesicle transport (GO:0048490)4.34362201
18ribosomal small subunit assembly (GO:0000028)4.27546275
19proteasome assembly (GO:0043248)4.23103486
20translational termination (GO:0006415)4.18212085
21positive regulation of interleukin-8 secretion (GO:2000484)4.04764050
22cGMP biosynthetic process (GO:0006182)4.01898736
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98816008
24translational elongation (GO:0006414)3.96208611
25cotranslational protein targeting to membrane (GO:0006613)3.95032464
26protein targeting to ER (GO:0045047)3.93002448
27mannosylation (GO:0097502)3.89356858
28immunoglobulin mediated immune response (GO:0016064)3.87649462
29deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.82947750
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.78560348
31purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.77468555
32positive regulation of mast cell activation involved in immune response (GO:0033008)3.69054181
33positive regulation of mast cell degranulation (GO:0043306)3.69054181
34ribosomal large subunit biogenesis (GO:0042273)3.69009167
35protein localization to endoplasmic reticulum (GO:0070972)3.67677866
36actin nucleation (GO:0045010)3.65869049
37maturation of SSU-rRNA (GO:0030490)3.56896090
38positive regulation of mast cell activation (GO:0033005)3.53585926
39purine nucleotide salvage (GO:0032261)3.51079569
40oxidative phosphorylation (GO:0006119)3.49931331
41negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.45916455
42DNA deamination (GO:0045006)3.44558047
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42710191
44adenosine metabolic process (GO:0046085)3.39302856
45cytidine metabolic process (GO:0046087)3.35926277
46cytidine catabolic process (GO:0006216)3.35926277
47cytidine deamination (GO:0009972)3.35926277
48aerobic respiration (GO:0009060)3.32418117
49B cell mediated immunity (GO:0019724)3.28077763
50mast cell activation (GO:0045576)3.27626911
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27204502
52neutrophil activation involved in immune response (GO:0002283)3.24135954
53one-carbon compound transport (GO:0019755)3.24128043
54regulation of interleukin-8 secretion (GO:2000482)3.23519480
55viral life cycle (GO:0019058)3.20123365
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16243995
57membrane invagination (GO:0010324)3.11016044
58deoxyribose phosphate metabolic process (GO:0019692)3.07455606
59execution phase of apoptosis (GO:0097194)3.05211081
60cellular protein complex disassembly (GO:0043624)2.99656127
61AMP metabolic process (GO:0046033)2.99057961
62protein complex biogenesis (GO:0070271)2.99050536
63purine deoxyribonucleotide metabolic process (GO:0009151)2.94871552
64translational initiation (GO:0006413)2.94385315
65purine-containing compound salvage (GO:0043101)2.92972347
66regulation of hypersensitivity (GO:0002883)2.92894215
67response to interferon-beta (GO:0035456)2.90846961
68interferon-gamma-mediated signaling pathway (GO:0060333)2.90197829
69deoxyribose phosphate catabolic process (GO:0046386)2.89491712
70cGMP metabolic process (GO:0046068)2.81803871
71hydrogen ion transmembrane transport (GO:1902600)2.80625006
72organelle disassembly (GO:1903008)2.78207849
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78142859
74mitochondrial respiratory chain complex assembly (GO:0033108)2.76764107
75protein targeting to membrane (GO:0006612)2.75872812
76regulation of cellular amino acid metabolic process (GO:0006521)2.71366869
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70736816
78purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70446748
79regulation of protein polyubiquitination (GO:1902914)2.68004229
80cellular response to interferon-gamma (GO:0071346)2.67782363
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67263873
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.64704233
83regulation of cytokine secretion involved in immune response (GO:0002739)2.63791477
84deoxyribonucleotide biosynthetic process (GO:0009263)2.63420193
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.63410773
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63293391
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63293391
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63085549
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63085549
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63085549
91positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61684197
92regulation of regulatory T cell differentiation (GO:0045589)2.60946536
93purinergic nucleotide receptor signaling pathway (GO:0035590)2.60241546
94positive regulation of monocyte chemotaxis (GO:0090026)2.59655122
95positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.58613991
96proton transport (GO:0015992)2.58008096
97translation (GO:0006412)2.57919817
98detection of bacterium (GO:0016045)2.57407011
99regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.56673495
100positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.56673495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.85802256
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.77099918
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.59229959
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.51544437
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.51425791
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.44562685
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.38997211
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.20780883
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11167482
10VDR_23849224_ChIP-Seq_CD4+_Human2.51013275
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.48369660
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39700170
13ELK1_19687146_ChIP-ChIP_HELA_Human2.26899878
14EWS_26573619_Chip-Seq_HEK293_Human2.24375237
15ZNF274_21170338_ChIP-Seq_K562_Hela2.09709206
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09307603
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07875122
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05253381
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.90405299
20TAF15_26573619_Chip-Seq_HEK293_Human1.88515509
21VDR_22108803_ChIP-Seq_LS180_Human1.87763674
22FOXP3_21729870_ChIP-Seq_TREG_Human1.80832340
23SPI1_23547873_ChIP-Seq_NB4_Human1.78776149
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.70917425
25GATA3_26560356_Chip-Seq_TH2_Human1.68360812
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65407393
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64763583
28MYB_26560356_Chip-Seq_TH2_Human1.64298245
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64258166
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54115354
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52936941
32IRF1_19129219_ChIP-ChIP_H3396_Human1.46761597
33AR_20517297_ChIP-Seq_VCAP_Human1.43552236
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43143673
35FUS_26573619_Chip-Seq_HEK293_Human1.42784333
36EZH2_22144423_ChIP-Seq_EOC_Human1.42251136
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39238560
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.39238560
39PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.38067468
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36212296
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33874273
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33006467
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32668868
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32276566
45NANOG_19829295_ChIP-Seq_ESCs_Human1.31145592
46SOX2_19829295_ChIP-Seq_ESCs_Human1.31145592
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29833572
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29382744
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26231998
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25884175
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25409640
52GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20977760
53BCAT_22108803_ChIP-Seq_LS180_Human1.20576176
54CIITA_25753668_ChIP-Seq_RAJI_Human1.19242823
55GATA3_27048872_Chip-Seq_THYMUS_Human1.18312788
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17318995
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15161449
58SALL4_22934838_ChIP-ChIP_CD34+_Human1.14667311
59CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13647886
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.12161431
61ER_23166858_ChIP-Seq_MCF-7_Human1.11984936
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11972552
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11758904
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10406885
65EGR1_19032775_ChIP-ChIP_M12_Human1.09858363
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09763917
67TAF2_19829295_ChIP-Seq_ESCs_Human1.09626788
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08113431
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.07101957
70TP53_22573176_ChIP-Seq_HFKS_Human1.07065702
71CBP_20019798_ChIP-Seq_JUKART_Human1.06679195
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06679195
73RUNX_20019798_ChIP-Seq_JUKART_Human1.06251282
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06166133
75P300_19829295_ChIP-Seq_ESCs_Human1.06001352
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05549315
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.03943235
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03385320
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00755476
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.99309544
81RNF2_27304074_Chip-Seq_NSC_Mouse0.98811843
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98751264
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96922162
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96177587
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94515111
86ELF5_23300383_ChIP-Seq_T47D_Human0.93209699
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92952951
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90616684
89NANOG_20526341_ChIP-Seq_ESCs_Human0.90488393
90TCF4_22108803_ChIP-Seq_LS180_Human0.90383460
91NCOR_22424771_ChIP-Seq_293T_Human0.90148065
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.89998910
93MYC_18940864_ChIP-ChIP_HL60_Human0.89518919
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.88112612
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87833094
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87502800
97ERG_20517297_ChIP-Seq_VCAP_Human0.86753896
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86682391
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86682391
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86319566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.88704910
2MP0001835_abnormal_antigen_presentation4.32703481
3MP0003806_abnormal_nucleotide_metabolis4.25306956
4MP0000569_abnormal_digit_pigmentation4.13303565
5MP0005671_abnormal_response_to3.69062846
6MP0002166_altered_tumor_susceptibility3.16357273
7MP0000516_abnormal_urinary_system2.59867084
8MP0005367_renal/urinary_system_phenotyp2.59867084
9MP0001529_abnormal_vocalization2.58593110
10MP0002006_tumorigenesis2.42825105
11MP0002132_abnormal_respiratory_system2.36736095
12MP0004147_increased_porphyrin_level2.33915538
13MP0009785_altered_susceptibility_to2.32334673
14MP0000372_irregular_coat_pigmentation2.14047217
15MP0005408_hypopigmentation2.02876470
16MP0009764_decreased_sensitivity_to1.99359082
17MP0001800_abnormal_humoral_immune1.98213213
18MP0005075_abnormal_melanosome_morpholog1.95248743
19MP0005645_abnormal_hypothalamus_physiol1.94345627
20MP0002138_abnormal_hepatobiliary_system1.91382463
21MP0005464_abnormal_platelet_physiology1.78981631
22MP0005670_abnormal_white_adipose1.75899520
23MP0002148_abnormal_hypersensitivity_rea1.74859644
24MP0005000_abnormal_immune_tolerance1.71591435
25MP0005174_abnormal_tail_pigmentation1.71427758
26MP0004142_abnormal_muscle_tone1.68138837
27MP0003252_abnormal_bile_duct1.62467228
28MP0002723_abnormal_immune_serum1.61935199
29MP0010155_abnormal_intestine_physiology1.58475869
30MP0000015_abnormal_ear_pigmentation1.56843216
31MP0002452_abnormal_antigen_presenting1.55530324
32MP0005084_abnormal_gallbladder_morpholo1.53738857
33MP0005025_abnormal_response_to1.52206891
34MP0002822_catalepsy1.50384391
35MP0002277_abnormal_respiratory_mucosa1.45079455
36MP0002420_abnormal_adaptive_immunity1.41846780
37MP0003724_increased_susceptibility_to1.40753658
38MP0001819_abnormal_immune_cell1.37679662
39MP0003011_delayed_dark_adaptation1.36558434
40MP0009697_abnormal_copulation1.29103590
41MP0003075_altered_response_to1.27533753
42MP0001764_abnormal_homeostasis1.25704535
43MP0003866_abnormal_defecation1.21502551
44MP0005646_abnormal_pituitary_gland1.20507856
45MP0002398_abnormal_bone_marrow1.18616236
46MP0005535_abnormal_body_temperature1.18392994
47MP0001873_stomach_inflammation1.18024628
48MP0000716_abnormal_immune_system1.16267676
49MP0002419_abnormal_innate_immunity1.15422604
50MP0001790_abnormal_immune_system1.12001836
51MP0005387_immune_system_phenotype1.12001836
52MP0002095_abnormal_skin_pigmentation1.10351654
53MP0008961_abnormal_basal_metabolism1.10047201
54MP0001853_heart_inflammation1.08830012
55MP0003191_abnormal_cellular_cholesterol1.08746392
56MP0003283_abnormal_digestive_organ1.05294427
57MP0001486_abnormal_startle_reflex1.02767688
58MP0003303_peritoneal_inflammation1.01683702
59MP0004808_abnormal_hematopoietic_stem0.99380313
60MP0008469_abnormal_protein_level0.99357002
61MP0002090_abnormal_vision0.98269451
62MP0004134_abnormal_chest_morphology0.98102674
63MP0006036_abnormal_mitochondrial_physio0.97785063
64MP0003763_abnormal_thymus_physiology0.97651797
65MP0000685_abnormal_immune_system0.97363624
66MP0005409_darkened_coat_color0.95090166
67MP0002837_dystrophic_cardiac_calcinosis0.91994827
68MP0001845_abnormal_inflammatory_respons0.89795464
69MP0002928_abnormal_bile_duct0.89192482
70MP0002429_abnormal_blood_cell0.88397747
71MP0005166_decreased_susceptibility_to0.88348291
72MP0005085_abnormal_gallbladder_physiolo0.87584456
73MP0002234_abnormal_pharynx_morphology0.85719981
74MP0009763_increased_sensitivity_to0.85173783
75MP0000343_altered_response_to0.82435463
76MP0004924_abnormal_behavior0.80322342
77MP0005386_behavior/neurological_phenoty0.80322342
78MP0008877_abnormal_DNA_methylation0.77790148
79MP0001324_abnormal_eye_pigmentation0.76803246
80MP0000566_synostosis0.76150748
81MP0000689_abnormal_spleen_morphology0.72884741
82MP0003136_yellow_coat_color0.72072993
83MP0004145_abnormal_muscle_electrophysio0.71152025
84MP0000703_abnormal_thymus_morphology0.69925487
85MP0001501_abnormal_sleep_pattern0.69826286
86MP0003646_muscle_fatigue0.69311379
87MP0006072_abnormal_retinal_apoptosis0.68084986
88MP0002722_abnormal_immune_system0.67871676
89MP0002396_abnormal_hematopoietic_system0.67819803
90MP0005551_abnormal_eye_electrophysiolog0.67747788
91MP0001177_atelectasis0.67543649
92MP0001440_abnormal_grooming_behavior0.67468879
93MP0001905_abnormal_dopamine_level0.66717930
94MP0001191_abnormal_skin_condition0.65249414
95MP0008873_increased_physiological_sensi0.63579340
96MP0003880_abnormal_central_pattern0.62757035
97MP0002405_respiratory_system_inflammati0.62213792
98MP0002272_abnormal_nervous_system0.61523415
99MP0001663_abnormal_digestive_system0.61431607
100MP0002938_white_spotting0.58040912

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)6.07492973
2Increased hepatocellular lipid droplets (HP:0006565)4.38018168
3Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.37371035
4Abnormal protein N-linked glycosylation (HP:0012347)4.37371035
5Abnormal protein glycosylation (HP:0012346)4.37371035
6Abnormal glycosylation (HP:0012345)4.37371035
7Mitochondrial inheritance (HP:0001427)4.33232644
8Acute necrotizing encephalopathy (HP:0006965)4.27926277
9Hepatocellular necrosis (HP:0001404)4.16901605
10Lipid accumulation in hepatocytes (HP:0006561)4.15783656
11Congenital, generalized hypertrichosis (HP:0004540)3.93295789
12Elevated erythrocyte sedimentation rate (HP:0003565)3.86899674
13Abnormal mitochondria in muscle tissue (HP:0008316)3.82088874
14Exertional dyspnea (HP:0002875)3.76724204
15Increased IgM level (HP:0003496)3.70841422
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.68794490
17Hepatic necrosis (HP:0002605)3.66039723
183-Methylglutaconic aciduria (HP:0003535)3.56267434
19Progressive macrocephaly (HP:0004481)3.53569146
20Reduced antithrombin III activity (HP:0001976)3.47006906
21Dry hair (HP:0011359)3.44892472
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.43936376
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.43936376
24Increased CSF lactate (HP:0002490)3.32659222
25Renal Fanconi syndrome (HP:0001994)3.21200709
26Acute encephalopathy (HP:0006846)3.19431096
27Fair hair (HP:0002286)3.14085573
28Metaphyseal dysplasia (HP:0100255)3.03290165
29Respiratory difficulties (HP:0002880)2.98684390
30Increased intramyocellular lipid droplets (HP:0012240)2.96549183
31Hypoproteinemia (HP:0003075)2.89183016
32Abnormality of renal resorption (HP:0011038)2.72866968
33Cerebral edema (HP:0002181)2.72280800
34Abnormality of B cell number (HP:0010975)2.71846872
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63428650
36Abnormal biliary tract physiology (HP:0012439)2.60348176
37Bile duct proliferation (HP:0001408)2.60348176
38Increased muscle lipid content (HP:0009058)2.58616291
39Petechiae (HP:0000967)2.58246350
40Abnormality of T cell number (HP:0011839)2.50151031
41Delayed CNS myelination (HP:0002188)2.46676225
42T lymphocytopenia (HP:0005403)2.45727111
43Generalized hypopigmentation of hair (HP:0011358)2.45232504
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42098659
45Azoospermia (HP:0000027)2.41902800
46Pancreatic fibrosis (HP:0100732)2.31257303
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.28762238
48Aplastic anemia (HP:0001915)2.28231206
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.26644878
50Absent/shortened dynein arms (HP:0200106)2.26644878
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.21466760
52Leukodystrophy (HP:0002415)2.18724848
53Macrocytic anemia (HP:0001972)2.17880434
54B lymphocytopenia (HP:0010976)2.15334256
55Dicarboxylic aciduria (HP:0003215)2.14548475
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14548475
57Concave nail (HP:0001598)2.11456524
58Abnormality of secondary sexual hair (HP:0009888)2.10582225
59Abnormality of the axillary hair (HP:0100134)2.10582225
60Lower limb hyperreflexia (HP:0002395)2.10222085
61Pancreatic cysts (HP:0001737)2.10077367
62Hypoplasia of the thymus (HP:0000778)2.09457289
63Ridged nail (HP:0001807)1.99840684
64Amyotrophic lateral sclerosis (HP:0007354)1.99248201
65Cerebral hemorrhage (HP:0001342)1.98694099
66Hyperventilation (HP:0002883)1.97352511
67Recurrent bacterial skin infections (HP:0005406)1.97252915
68Type II lissencephaly (HP:0007260)1.96945919
69Increased serum lactate (HP:0002151)1.95078794
70Pustule (HP:0200039)1.90970512
71Agammaglobulinemia (HP:0004432)1.89563894
72Progressive microcephaly (HP:0000253)1.89108751
73Respiratory failure (HP:0002878)1.87439419
74Recurrent abscess formation (HP:0002722)1.87115350
75Absence seizures (HP:0002121)1.86700918
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84542633
77Abnormality of T cells (HP:0002843)1.84259846
78Lactic acidosis (HP:0003128)1.83569850
79Rimmed vacuoles (HP:0003805)1.83483533
80Albinism (HP:0001022)1.82521606
81Panhypogammaglobulinemia (HP:0003139)1.81776105
82Optic disc pallor (HP:0000543)1.81526908
83Agitation (HP:0000713)1.76635395
84Cerebellar dysplasia (HP:0007033)1.75715346
85Abnormal rod and cone electroretinograms (HP:0008323)1.74439711
86Abnormality of lateral ventricle (HP:0030047)1.68568577
87Severe combined immunodeficiency (HP:0004430)1.68433007
88Focal motor seizures (HP:0011153)1.67164963
89Recurrent cutaneous fungal infections (HP:0011370)1.66762478
90Chronic mucocutaneous candidiasis (HP:0002728)1.66762478
91Lethargy (HP:0001254)1.66131413
92Abnormality of midbrain morphology (HP:0002418)1.65535802
93Molar tooth sign on MRI (HP:0002419)1.65535802
94Median cleft lip (HP:0000161)1.64895941
95Atrioventricular block (HP:0001678)1.64701946
96Hyperphosphaturia (HP:0003109)1.62517686
97Muscle fiber atrophy (HP:0100295)1.62482376
98Encephalitis (HP:0002383)1.62282569
99Hypothermia (HP:0002045)1.61103906
100Myokymia (HP:0002411)1.60936412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.37640324
2MAP4K24.21995249
3BMPR24.07591555
4ZAK3.51101309
5TLK13.39836850
6VRK23.29429289
7CDC73.15637362
8TAOK32.64035583
9CDK192.35424199
10KDR2.33401329
11MYLK2.21979038
12MST42.00116555
13VRK11.91870162
14BLK1.83171463
15WNK41.71182142
16SCYL21.68600428
17TEC1.65203728
18TYRO31.61340258
19KIT1.60422703
20ERBB31.53090686
21CSF1R1.49156317
22PIK3CG1.47763310
23STK241.43791417
24IKBKB1.38951785
25ILK1.34351984
26SYK1.33528095
27ADRBK21.30433004
28DAPK31.24736196
29TESK21.23831089
30TXK1.18020765
31DAPK11.15489331
32OXSR11.09410802
33CDK81.05830707
34ITK1.04387434
35MAP3K30.96478589
36BCKDK0.96231492
37BRSK20.94566920
38HCK0.93187349
39GRK60.92597011
40MAP3K140.91301832
41TNIK0.91053186
42BTK0.88418166
43STK38L0.87645943
44LYN0.87208755
45MAP2K30.85914093
46FRK0.85070278
47CHUK0.83454665
48FES0.81541538
49ZAP700.80888479
50NUAK10.76748795
51TAF10.72705730
52RIPK40.71193688
53MAP4K10.69876236
54MATK0.66388593
55AURKB0.64721623
56INSRR0.64641691
57BMPR1B0.61240379
58GRK10.58718798
59TYK20.58308400
60NME10.58142855
61SRPK10.57478138
62LCK0.57252197
63PINK10.56978839
64IGF1R0.54678977
65PKN10.54483730
66TAOK20.52223604
67OBSCN0.51939128
68STK390.51408516
69CSNK2A20.51272071
70EIF2AK20.49325145
71DAPK20.49208578
72ROCK10.47458164
73CSK0.46677308
74ATR0.44990532
75STK30.44474707
76AKT20.43141965
77PRKCQ0.41846093
78JAK30.40538587
79PRKG10.40517124
80IKBKE0.40073066
81TRPM70.40061715
82FYN0.36905452
83CCNB10.36363420
84RPS6KA50.35219328
85NME20.34988075
86PRKCD0.33418338
87CDK30.32885727
88ADRBK10.31199602
89MUSK0.30063897
90CDK140.28704090
91PRKCE0.27591834
92PRKACA0.27551255
93CSNK2A10.27225257
94TIE10.26603666
95MET0.26396598
96PRKCA0.25536753
97PAK10.25419191
98PIM10.25205842
99ABL10.24112071
100EGFR0.23945367

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.95084034
2Oxidative phosphorylation_Homo sapiens_hsa001903.72685216
3Allograft rejection_Homo sapiens_hsa053303.72571354
4Autoimmune thyroid disease_Homo sapiens_hsa053203.57429891
5Graft-versus-host disease_Homo sapiens_hsa053323.55544263
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.42054804
7Proteasome_Homo sapiens_hsa030503.26965798
8Parkinsons disease_Homo sapiens_hsa050123.14732214
9Ribosome_Homo sapiens_hsa030103.11398316
10Type I diabetes mellitus_Homo sapiens_hsa049402.91656401
11Antigen processing and presentation_Homo sapiens_hsa046122.54983468
12Huntingtons disease_Homo sapiens_hsa050162.23520435
13Staphylococcus aureus infection_Homo sapiens_hsa051502.21609790
14Alzheimers disease_Homo sapiens_hsa050102.19521950
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.02487082
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98190956
17Protein export_Homo sapiens_hsa030601.91605592
18Rheumatoid arthritis_Homo sapiens_hsa053231.79467632
19Leishmaniasis_Homo sapiens_hsa051401.74968717
20Viral myocarditis_Homo sapiens_hsa054161.71611438
21Cardiac muscle contraction_Homo sapiens_hsa042601.69983498
22RNA polymerase_Homo sapiens_hsa030201.46951984
23Regulation of autophagy_Homo sapiens_hsa041401.45534148
24Systemic lupus erythematosus_Homo sapiens_hsa053221.45416579
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39919440
26Homologous recombination_Homo sapiens_hsa034401.37900889
27Primary immunodeficiency_Homo sapiens_hsa053401.32704104
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29579663
29Sulfur metabolism_Homo sapiens_hsa009201.17702940
30N-Glycan biosynthesis_Homo sapiens_hsa005101.08511030
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02436278
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01496227
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98942100
34RNA degradation_Homo sapiens_hsa030180.87603231
35Hematopoietic cell lineage_Homo sapiens_hsa046400.86327760
36African trypanosomiasis_Homo sapiens_hsa051430.82394957
37Purine metabolism_Homo sapiens_hsa002300.80367083
38Tuberculosis_Homo sapiens_hsa051520.80093395
39Collecting duct acid secretion_Homo sapiens_hsa049660.76906800
40Toxoplasmosis_Homo sapiens_hsa051450.76465830
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75155675
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73894210
43Epstein-Barr virus infection_Homo sapiens_hsa051690.72729032
44Spliceosome_Homo sapiens_hsa030400.71984936
45Legionellosis_Homo sapiens_hsa051340.68376409
46Phagosome_Homo sapiens_hsa041450.68118239
47Nucleotide excision repair_Homo sapiens_hsa034200.65368451
48Nitrogen metabolism_Homo sapiens_hsa009100.63213719
49Olfactory transduction_Homo sapiens_hsa047400.61922680
50Herpes simplex infection_Homo sapiens_hsa051680.60555331
51Chemical carcinogenesis_Homo sapiens_hsa052040.58708393
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58669146
53Salmonella infection_Homo sapiens_hsa051320.56595171
54Non-homologous end-joining_Homo sapiens_hsa034500.55324157
55Linoleic acid metabolism_Homo sapiens_hsa005910.55185236
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54855894
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54745724
58Vitamin digestion and absorption_Homo sapiens_hsa049770.54298019
59Phototransduction_Homo sapiens_hsa047440.53362195
60Influenza A_Homo sapiens_hsa051640.51438097
61Glutathione metabolism_Homo sapiens_hsa004800.50276903
62Arachidonic acid metabolism_Homo sapiens_hsa005900.49339386
63Pyrimidine metabolism_Homo sapiens_hsa002400.48878341
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.45832754
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44244237
66Mismatch repair_Homo sapiens_hsa034300.44237656
67Platelet activation_Homo sapiens_hsa046110.42303220
68Fanconi anemia pathway_Homo sapiens_hsa034600.41732207
69Peroxisome_Homo sapiens_hsa041460.39445430
70Pertussis_Homo sapiens_hsa051330.38489938
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.38023960
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37287054
73Butanoate metabolism_Homo sapiens_hsa006500.35666972
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34135715
75One carbon pool by folate_Homo sapiens_hsa006700.33058597
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32102195
77Shigellosis_Homo sapiens_hsa051310.31791418
78Circadian entrainment_Homo sapiens_hsa047130.30589851
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.30277072
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28295447
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.27838785
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27304391
83Retinol metabolism_Homo sapiens_hsa008300.26580538
84Salivary secretion_Homo sapiens_hsa049700.26176061
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25502915
86Renin secretion_Homo sapiens_hsa049240.24514065
87Metabolic pathways_Homo sapiens_hsa011000.23278855
88Osteoclast differentiation_Homo sapiens_hsa043800.20942478
89Fatty acid degradation_Homo sapiens_hsa000710.19619928
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19596133
91Tryptophan metabolism_Homo sapiens_hsa003800.18820826
92DNA replication_Homo sapiens_hsa030300.18353252
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.17588804
94Alcoholism_Homo sapiens_hsa050340.17278402
95Serotonergic synapse_Homo sapiens_hsa047260.17102731
96Nicotine addiction_Homo sapiens_hsa050330.16676599
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15377416
98Oxytocin signaling pathway_Homo sapiens_hsa049210.15363977
99Calcium signaling pathway_Homo sapiens_hsa040200.14364985
100Taste transduction_Homo sapiens_hsa047420.13723155

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