LGALSL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.24182679
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.81164713
3synaptic vesicle maturation (GO:0016188)4.72968003
4regulation of water loss via skin (GO:0033561)4.68649621
5keratinocyte development (GO:0003334)4.44028604
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40509907
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.18826541
8synaptic vesicle exocytosis (GO:0016079)4.11015024
9glutamate secretion (GO:0014047)4.08261265
10retinal cone cell development (GO:0046549)4.03839262
11regulation of synaptic vesicle exocytosis (GO:2000300)4.02700627
12positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.96602796
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96268743
14thrombin receptor signaling pathway (GO:0070493)3.93721441
15locomotory exploration behavior (GO:0035641)3.88072008
16regulation of rhodopsin mediated signaling pathway (GO:0022400)3.87961887
17rhodopsin mediated signaling pathway (GO:0016056)3.83948260
18long-chain fatty acid biosynthetic process (GO:0042759)3.79420839
19fatty acid elongation (GO:0030497)3.78186209
20desmosome organization (GO:0002934)3.78039410
21vocalization behavior (GO:0071625)3.75960657
22negative regulation of norepinephrine secretion (GO:0010700)3.63656864
23layer formation in cerebral cortex (GO:0021819)3.62922026
24protein localization to synapse (GO:0035418)3.59470839
25regulation of synaptic vesicle transport (GO:1902803)3.48887743
26cellular potassium ion homeostasis (GO:0030007)3.45402005
27photoreceptor cell development (GO:0042461)3.44812140
28neurotransmitter secretion (GO:0007269)3.43757111
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43504254
30positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.40529733
31retinal rod cell development (GO:0046548)3.36041255
32sodium ion export (GO:0071436)3.34399703
33positive regulation of synapse maturation (GO:0090129)3.28609210
34keratinization (GO:0031424)3.28600197
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28183874
36eye photoreceptor cell development (GO:0042462)3.27712760
37neurotransmitter-gated ion channel clustering (GO:0072578)3.25017341
38response to pheromone (GO:0019236)3.24951061
39negative regulation of heart rate (GO:0010459)3.24266857
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.22661594
41negative regulation of response to food (GO:0032096)3.19034278
42negative regulation of appetite (GO:0032099)3.19034278
43platelet dense granule organization (GO:0060155)3.16376589
44regulation of glutamate receptor signaling pathway (GO:1900449)3.15400845
45phosphatidylinositol acyl-chain remodeling (GO:0036149)3.13520262
46cell communication by electrical coupling (GO:0010644)3.11405112
47blood coagulation, intrinsic pathway (GO:0007597)3.07602169
48sarcoplasmic reticulum calcium ion transport (GO:0070296)3.06932735
49activation of protein kinase A activity (GO:0034199)3.00339274
50negative regulation of protein localization to cell surface (GO:2000009)2.99510926
51cell communication involved in cardiac conduction (GO:0086065)2.98177648
52detection of light stimulus involved in sensory perception (GO:0050962)2.98011443
53detection of light stimulus involved in visual perception (GO:0050908)2.98011443
54regulation of clathrin-mediated endocytosis (GO:2000369)2.96574993
55regulation of synapse structural plasticity (GO:0051823)2.96475603
56dendritic spine morphogenesis (GO:0060997)2.96274483
57exploration behavior (GO:0035640)2.92681700
58regulation of lipoprotein metabolic process (GO:0050746)2.92359258
59positive regulation of endothelial cell differentiation (GO:0045603)2.92262336
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.91776711
61regulation of Golgi to plasma membrane protein transport (GO:0042996)2.87544642
62regulation of skeletal muscle contraction (GO:0014819)2.86870857
63innervation (GO:0060384)2.86405359
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85058693
65multicellular organismal water homeostasis (GO:0050891)2.83179589
66regulation of protein glycosylation (GO:0060049)2.82913934
67proline transport (GO:0015824)2.82552637
68leukocyte migration involved in inflammatory response (GO:0002523)2.81474491
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.77753105
70bundle of His cell to Purkinje myocyte communication (GO:0086069)2.73996176
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73941902
72positive regulation of vesicle fusion (GO:0031340)2.72647856
73beta-amyloid metabolic process (GO:0050435)2.72614734
74keratinocyte differentiation (GO:0030216)2.72487122
75neurotransmitter transport (GO:0006836)2.72204042
76regulation of neuronal synaptic plasticity (GO:0048168)2.72108676
77neuronal action potential propagation (GO:0019227)2.71422672
78dopamine transport (GO:0015872)2.71072156
79chemosensory behavior (GO:0007635)2.71024421
80relaxation of muscle (GO:0090075)2.70629462
81neuron cell-cell adhesion (GO:0007158)2.69238906
82cerebellar Purkinje cell differentiation (GO:0021702)2.69029179
83plasma membrane repair (GO:0001778)2.68990349
84neuron-neuron synaptic transmission (GO:0007270)2.68586107
85negative regulation of catecholamine secretion (GO:0033604)2.67685024
86dendrite morphogenesis (GO:0048813)2.67263106
87phosphatidylserine acyl-chain remodeling (GO:0036150)2.67193327
88glycerophospholipid catabolic process (GO:0046475)2.65937906
89detection of light stimulus (GO:0009583)2.64931279
90regulation of heart rate by cardiac conduction (GO:0086091)2.64353653
91phototransduction (GO:0007602)2.64112534
92vesicle transport along microtubule (GO:0047496)2.63117246
93photoreceptor cell maintenance (GO:0045494)2.62178352
94phospholipid catabolic process (GO:0009395)2.61908387
95synaptic transmission, glutamatergic (GO:0035249)2.61347018
96regulation of neurotransmitter secretion (GO:0046928)2.60640494
97detection of visible light (GO:0009584)2.60353192
98phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.59836563
99establishment of skin barrier (GO:0061436)2.59144176
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58844676
101neuron recognition (GO:0008038)2.57847949
102phospholipid homeostasis (GO:0055091)2.57599750
103calcium ion import (GO:0070509)2.56616549
104relaxation of cardiac muscle (GO:0055119)2.56564534
105acrosome assembly (GO:0001675)2.56319905
106water homeostasis (GO:0030104)2.56118936
107positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.55255903
108long-term synaptic potentiation (GO:0060291)2.54198509
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.53596239
110L-phenylalanine catabolic process (GO:0006559)2.53596239
111regulation of integrin-mediated signaling pathway (GO:2001044)2.53449348
112cardiac conduction (GO:0061337)2.53286986
113presynaptic membrane assembly (GO:0097105)2.52907815
114muscle filament sliding (GO:0030049)2.52476386
115actin-myosin filament sliding (GO:0033275)2.52476386
116axonal fasciculation (GO:0007413)2.52224788
117regulation of vesicle fusion (GO:0031338)2.52102103
118phototransduction, visible light (GO:0007603)2.51605250
119sphingosine metabolic process (GO:0006670)2.51597091
120nucleobase catabolic process (GO:0046113)2.51508738
121synaptic vesicle endocytosis (GO:0048488)2.51376007
122positive regulation of membrane potential (GO:0045838)2.51176139
123negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.50306245
124skeletal muscle tissue regeneration (GO:0043403)2.49335206
125inositol phosphate catabolic process (GO:0071545)2.49059581
126atrial cardiac muscle cell action potential (GO:0086014)2.48786119
127cerebellar granule cell differentiation (GO:0021707)2.48617698
128lipoxygenase pathway (GO:0019372)2.47767295
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47300137
130potassium ion import (GO:0010107)2.47112535
131gamma-aminobutyric acid transport (GO:0015812)2.46541927
132regulation of dendritic spine morphogenesis (GO:0061001)2.46352163
133negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.45954168
134negative regulation of calcium ion transmembrane transport (GO:1903170)2.45954168
135regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.45678335
136potassium ion homeostasis (GO:0055075)2.45436187
137actin-mediated cell contraction (GO:0070252)2.45020067
138positive regulation of guanylate cyclase activity (GO:0031284)2.44862673
139regulation of voltage-gated calcium channel activity (GO:1901385)2.44628630
140membrane repolarization (GO:0086009)2.44551246
141glutamate receptor signaling pathway (GO:0007215)2.44534399
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43800886
143regulation of postsynaptic membrane potential (GO:0060078)2.43578162
144regulation of excitatory postsynaptic membrane potential (GO:0060079)2.43565859
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43221357
146polarized epithelial cell differentiation (GO:0030859)2.42421102
147phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.42335794
148regulation of protein localization to cell surface (GO:2000008)2.42273948
149protein-chromophore linkage (GO:0018298)2.39949869
150sphingoid metabolic process (GO:0046519)2.39468949
151regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.39378173
152cardiac muscle cell action potential (GO:0086001)2.38989666
153dendritic spine organization (GO:0097061)2.38612092
154membrane hyperpolarization (GO:0060081)2.38341783
155regulation of acyl-CoA biosynthetic process (GO:0050812)2.37883847
156response to histamine (GO:0034776)2.37732771
157positive regulation of glycolytic process (GO:0045821)2.37710808
158long-term memory (GO:0007616)2.37602719
159ionotropic glutamate receptor signaling pathway (GO:0035235)2.37545178
160regulation of meiosis I (GO:0060631)2.37125575
161diol metabolic process (GO:0034311)2.35856696
162neuromuscular process controlling balance (GO:0050885)2.35653283
163organelle transport along microtubule (GO:0072384)2.35641493
164keratinocyte proliferation (GO:0043616)2.35426004
165behavioral response to cocaine (GO:0048148)2.35308297
166positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.34961908
167regulation of neurotransmitter transport (GO:0051588)2.34840061
168negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.34705228
169regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.34042192
170cardiac muscle cell action potential involved in contraction (GO:0086002)2.33034540
171negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.33025026
172nitric oxide mediated signal transduction (GO:0007263)2.32788945
173negative regulation of cation channel activity (GO:2001258)2.31524233
174regulation of norepinephrine secretion (GO:0014061)2.31425338
175regulation of cell communication by electrical coupling (GO:0010649)2.30490939
176reverse cholesterol transport (GO:0043691)2.29347615
177regulation of sodium ion transmembrane transporter activity (GO:2000649)2.28207657
178polyol catabolic process (GO:0046174)2.27249133
179mitochondrial calcium ion homeostasis (GO:0051560)2.26833431
180auditory receptor cell differentiation (GO:0042491)2.26607485
181myelin assembly (GO:0032288)2.24723386
182phosphorylated carbohydrate dephosphorylation (GO:0046838)2.22624038
183inositol phosphate dephosphorylation (GO:0046855)2.22624038
184response to nitrosative stress (GO:0051409)2.22499716
185termination of G-protein coupled receptor signaling pathway (GO:0038032)2.21924958
186linoleic acid metabolic process (GO:0043651)2.21411657
187phosphatidylcholine acyl-chain remodeling (GO:0036151)2.21380380
188negative regulation of cytosolic calcium ion concentration (GO:0051481)2.21327888
189positive regulation of meiotic cell cycle (GO:0051446)2.21304320
190detection of calcium ion (GO:0005513)2.20881455
191regulation of relaxation of muscle (GO:1901077)2.19392425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.94466965
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89991186
3IGF1R_20145208_ChIP-Seq_DFB_Human2.85277326
4TAF15_26573619_Chip-Seq_HEK293_Human2.73585134
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65226710
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.59468279
7GBX2_23144817_ChIP-Seq_PC3_Human2.51903371
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49377388
9FUS_26573619_Chip-Seq_HEK293_Human2.28423931
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27871189
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27871189
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18751730
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17493636
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15697436
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13831765
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09831960
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06724520
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05282775
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.05278336
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96272397
21AR_21572438_ChIP-Seq_LNCaP_Human1.95621217
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.94828980
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.94386685
24DROSHA_22980978_ChIP-Seq_HELA_Human1.94222562
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90914176
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.84713535
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.84163792
28EWS_26573619_Chip-Seq_HEK293_Human1.80053144
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.79739432
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78125815
31REST_21632747_ChIP-Seq_MESCs_Mouse1.77883464
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75734691
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74106695
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73868473
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64033650
36ER_23166858_ChIP-Seq_MCF-7_Human1.62007098
37HTT_18923047_ChIP-ChIP_STHdh_Human1.59684169
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.55951751
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.55878659
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55290704
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55290704
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53698470
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51935266
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.48853371
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47843565
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46431460
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46197545
48SMAD4_21799915_ChIP-Seq_A2780_Human1.45413355
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43145019
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.43003521
51SOX2_19829295_ChIP-Seq_ESCs_Human1.42846270
52NANOG_19829295_ChIP-Seq_ESCs_Human1.42846270
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41958373
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41886607
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38330938
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38159658
57RNF2_27304074_Chip-Seq_NSC_Mouse1.37131101
58TCF4_23295773_ChIP-Seq_U87_Human1.37078592
59CDX2_22108803_ChIP-Seq_LS180_Human1.35707587
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.32861441
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32539258
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.32475781
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32354325
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.32221327
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30959976
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29607286
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29536633
68ZNF274_21170338_ChIP-Seq_K562_Hela1.29058809
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.29008892
70AHR_22903824_ChIP-Seq_MCF-7_Human1.28101553
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.27973443
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.27562697
73AR_19668381_ChIP-Seq_PC3_Human1.25263203
74BCAT_22108803_ChIP-Seq_LS180_Human1.24969694
75P53_22387025_ChIP-Seq_ESCs_Mouse1.24842971
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24552338
77CBP_20019798_ChIP-Seq_JUKART_Human1.24552338
78ZNF263_19887448_ChIP-Seq_K562_Human1.23881136
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23147591
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23130266
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.23110259
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22643344
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22643344
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22377504
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21511739
86AR_25329375_ChIP-Seq_VCAP_Human1.21076266
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20955690
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20919048
89KDM2B_26808549_Chip-Seq_K562_Human1.20040309
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19969118
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.19923550
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19840102
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.19815701
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18957806
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.18856810
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18670655
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18442598
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.17999158
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.17905881
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.17163548
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17160557
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16060473
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15878010
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.14589285
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.14561141
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13872949
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.13861481
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13761612
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13672201
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13270582
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.12847026
112STAT3_23295773_ChIP-Seq_U87_Human1.11939097
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11394584
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10966986
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10642717
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10466545
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.10303629
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09722642
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09103251
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07980992
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07951904
122RXR_22108803_ChIP-Seq_LS180_Human1.07825258
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.07573879
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.07267820
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06843704
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06715571
127RUNX2_22187159_ChIP-Seq_PCA_Human1.06278831
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04689601
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.04689319
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04138211
131P300_19829295_ChIP-Seq_ESCs_Human1.02962168
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02175260
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02084917
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01595849
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01595295
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99933248
137SOX2_18555785_Chip-Seq_ESCs_Mouse0.99813015
138P300_18555785_Chip-Seq_ESCs_Mouse0.99771932
139VDR_22108803_ChIP-Seq_LS180_Human0.99499320
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.98752651
141TP63_23658742_ChIP-Seq_EP156T_Human0.98751381
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97810668
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97380664
144TP53_16413492_ChIP-PET_HCT116_Human0.97352067
145TBL1_22424771_ChIP-Seq_293T_Human0.96891621
146TP53_18474530_ChIP-ChIP_U2OS_Human0.94930634
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94911536
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94833314
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94207193
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.93758897
151ESR2_21235772_ChIP-Seq_MCF-7_Human0.93655068
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93580039
153TP53_20018659_ChIP-ChIP_R1E_Mouse0.93089586
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92640667
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92593537
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.91729887
157ISL1_27105846_Chip-Seq_CPCs_Mouse0.91344549
158CLOCK_20551151_ChIP-Seq_293T_Human0.90521203
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89938489
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87746728
161TCF4_22108803_ChIP-Seq_LS180_Human0.87190140
162NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86319587
163CTCF_27219007_Chip-Seq_Bcells_Human0.86283619
164CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85154290
165ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85074283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.90116746
2MP0005551_abnormal_eye_electrophysiolog3.59364224
3MP0005464_abnormal_platelet_physiology3.19613643
4MP0008004_abnormal_stomach_pH3.00342189
5MP0003011_delayed_dark_adaptation2.98440589
6MP0005275_abnormal_skin_tensile2.94953469
7MP0003136_yellow_coat_color2.79917359
8MP0009780_abnormal_chondrocyte_physiolo2.79115145
9MP0006072_abnormal_retinal_apoptosis2.76612366
10MP0010234_abnormal_vibrissa_follicle2.69990185
11MP0002796_impaired_skin_barrier2.63321371
12MP0003635_abnormal_synaptic_transmissio2.59814221
13MP0004270_analgesia2.59068054
14MP0003195_calcinosis2.46203945
15MP0003646_muscle_fatigue2.37170559
16MP0005253_abnormal_eye_physiology2.30889347
17MP0003880_abnormal_central_pattern2.14498755
18MP0002063_abnormal_learning/memory/cond2.12431191
19MP0003705_abnormal_hypodermis_morpholog2.04354954
20MP0010678_abnormal_skin_adnexa2.04086596
21MP0002909_abnormal_adrenal_gland1.94937026
22MP0005084_abnormal_gallbladder_morpholo1.88873926
23MP0003787_abnormal_imprinting1.84088349
24MP0000013_abnormal_adipose_tissue1.84022096
25MP0000579_abnormal_nail_morphology1.79790048
26MP0008877_abnormal_DNA_methylation1.79513342
27MP0009745_abnormal_behavioral_response1.76858018
28MP0000383_abnormal_hair_follicle1.72040733
29MP0002090_abnormal_vision1.71155224
30MP0000751_myopathy1.69162540
31MP0004233_abnormal_muscle_weight1.66962217
32MP0009046_muscle_twitch1.66216282
33MP0002064_seizures1.64525121
34MP0005423_abnormal_somatic_nervous1.63190197
35MP0002734_abnormal_mechanical_nocicepti1.61371018
36MP0004145_abnormal_muscle_electrophysio1.59962866
37MP0002572_abnormal_emotion/affect_behav1.57742947
38MP0005174_abnormal_tail_pigmentation1.52056125
39MP0010329_abnormal_lipoprotein_level1.50469791
40MP0004510_myositis1.48328232
41MP0001984_abnormal_olfaction1.48079795
42MP0006276_abnormal_autonomic_nervous1.45968565
43MP0002234_abnormal_pharynx_morphology1.44501839
44MP0004885_abnormal_endolymph1.38291170
45MP0002837_dystrophic_cardiac_calcinosis1.37085737
46MP0001486_abnormal_startle_reflex1.35676706
47MP0005501_abnormal_skin_physiology1.35559783
48MP0001968_abnormal_touch/_nociception1.34339968
49MP0002272_abnormal_nervous_system1.31910856
50MP0005187_abnormal_penis_morphology1.30940235
51MP0003283_abnormal_digestive_organ1.28718424
52MP0005195_abnormal_posterior_eye1.28673613
53MP0004858_abnormal_nervous_system1.27749836
54MP0002822_catalepsy1.27523501
55MP0000230_abnormal_systemic_arterial1.27405305
56MP0002938_white_spotting1.27203686
57MP0004147_increased_porphyrin_level1.25814397
58MP0008569_lethality_at_weaning1.24181176
59MP0001502_abnormal_circadian_rhythm1.23091519
60MP0000569_abnormal_digit_pigmentation1.19407135
61MP0000516_abnormal_urinary_system1.18758528
62MP0005367_renal/urinary_system_phenotyp1.18758528
63MP0003329_amyloid_beta_deposits1.17365304
64MP0004215_abnormal_myocardial_fiber1.17196450
65MP0002882_abnormal_neuron_morphology1.16131347
66MP0005620_abnormal_muscle_contractility1.15402064
67MP0002184_abnormal_innervation1.15238733
68MP0001299_abnormal_eye_distance/1.13997578
69MP0000015_abnormal_ear_pigmentation1.13402574
70MP0002067_abnormal_sensory_capabilities1.10179185
71MP0001501_abnormal_sleep_pattern1.10018263
72MP0005248_abnormal_Harderian_gland1.09946287
73MP0004811_abnormal_neuron_physiology1.09833846
74MP0000372_irregular_coat_pigmentation1.09426191
75MP0003890_abnormal_embryonic-extraembry1.08760947
76MP0004130_abnormal_muscle_cell1.08430145
77MP0002095_abnormal_skin_pigmentation1.07874402
78MP0008775_abnormal_heart_ventricle1.06746916
79MP0001324_abnormal_eye_pigmentation1.06062383
80MP0004036_abnormal_muscle_relaxation1.06036860
81MP0000778_abnormal_nervous_system1.05615950
82MP0005365_abnormal_bile_salt1.03588835
83MP0003121_genomic_imprinting1.03350782
84MP0006054_spinal_hemorrhage1.03328560
85MP0002557_abnormal_social/conspecific_i1.02528004
86MP0002229_neurodegeneration1.01291730
87MP0005646_abnormal_pituitary_gland1.01124763
88MP0000465_gastrointestinal_hemorrhage1.00797871
89MP0004924_abnormal_behavior1.00206616
90MP0005386_behavior/neurological_phenoty1.00206616
91MP0002877_abnormal_melanocyte_morpholog0.99900712
92MP0001485_abnormal_pinna_reflex0.99432646
93MP0003941_abnormal_skin_development0.99071202
94MP0002106_abnormal_muscle_physiology0.97978194
95MP0008872_abnormal_physiological_respon0.97872488
96MP0003878_abnormal_ear_physiology0.97640460
97MP0005377_hearing/vestibular/ear_phenot0.97640460
98MP0005409_darkened_coat_color0.97403713
99MP0003638_abnormal_response/metabolism_0.96858200
100MP0004085_abnormal_heartbeat0.96025725
101MP0004142_abnormal_muscle_tone0.95799016
102MP0010771_integument_phenotype0.95416522
103MP0004084_abnormal_cardiac_muscle0.94924116
104MP0005391_vision/eye_phenotype0.94240006
105MP0008961_abnormal_basal_metabolism0.93234661
106MP0001440_abnormal_grooming_behavior0.92141659
107MP0002653_abnormal_ependyma_morphology0.91641877
108MP0000647_abnormal_sebaceous_gland0.91287652
109MP0000955_abnormal_spinal_cord0.91264519
110MP0003122_maternal_imprinting0.90455821
111MP0003724_increased_susceptibility_to0.90117769
112MP0003137_abnormal_impulse_conducting0.90086444
113MP0003950_abnormal_plasma_membrane0.89717386
114MP0002733_abnormal_thermal_nociception0.89112203
115MP0005645_abnormal_hypothalamus_physiol0.88748426
116MP0003879_abnormal_hair_cell0.87836235
117MP0000467_abnormal_esophagus_morphology0.87766834
118MP0002752_abnormal_somatic_nervous0.85636271
119MP0010386_abnormal_urinary_bladder0.85080770
120MP0000377_abnormal_hair_follicle0.85009025
121MP0002254_reproductive_system_inflammat0.84695201
122MP0005623_abnormal_meninges_morphology0.84335189
123MP0001177_atelectasis0.84197457
124MP0000427_abnormal_hair_cycle0.83688803
125MP0002060_abnormal_skin_morphology0.83400682
126MP0002102_abnormal_ear_morphology0.83004511
127MP0001970_abnormal_pain_threshold0.82815249
128MP0002638_abnormal_pupillary_reflex0.82567815
129MP0006036_abnormal_mitochondrial_physio0.82524889
130MP0001756_abnormal_urination0.82287232
131MP0002108_abnormal_muscle_morphology0.81919579
132MP0001661_extended_life_span0.81595314
133MP0000749_muscle_degeneration0.80726929
134MP0002896_abnormal_bone_mineralization0.80541507
135MP0003123_paternal_imprinting0.80213865
136MP0002736_abnormal_nociception_after0.79585723
137MP0000747_muscle_weakness0.79451627
138MP0005499_abnormal_olfactory_system0.79392244
139MP0005394_taste/olfaction_phenotype0.79392244
140MP0001188_hyperpigmentation0.79268748
141MP0004381_abnormal_hair_follicle0.78752429
142MP0002066_abnormal_motor_capabilities/c0.78537789
143MP0001216_abnormal_epidermal_layer0.74460261
144MP0002972_abnormal_cardiac_muscle0.74122453
145MP0004087_abnormal_muscle_fiber0.73784138
146MP0004043_abnormal_pH_regulation0.73190572
147MP0000534_abnormal_ureter_morphology0.73011119
148MP0000762_abnormal_tongue_morphology0.71134138
149MP0004484_altered_response_of0.70620114
150MP0008438_abnormal_cutaneous_collagen0.70235950

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.77038757
2Increased mean platelet volume (HP:0011877)4.96380936
3Central scotoma (HP:0000603)4.76448857
4Prolonged bleeding time (HP:0003010)4.74207715
5Menorrhagia (HP:0000132)4.72704728
6Petechiae (HP:0000967)4.62149411
7Abnormal platelet volume (HP:0011876)4.40832084
8Bony spicule pigmentary retinopathy (HP:0007737)4.38891925
9Chorioretinal atrophy (HP:0000533)4.11390885
10Scotoma (HP:0000575)4.08376163
11Pigmentary retinal degeneration (HP:0001146)3.94519555
12Nemaline bodies (HP:0003798)3.74467460
13Abnormality of macular pigmentation (HP:0008002)3.72328875
14Abnormal rod and cone electroretinograms (HP:0008323)3.67143635
15Focal motor seizures (HP:0011153)3.59891454
16Dyschromatopsia (HP:0007641)3.51806483
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.48485745
18Purpura (HP:0000979)3.44297932
19Acanthocytosis (HP:0001927)3.41452266
20Erythroderma (HP:0001019)3.31278257
21Epileptic encephalopathy (HP:0200134)3.28732695
22Visual hallucinations (HP:0002367)3.21658272
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.10583824
24Exercise-induced myalgia (HP:0003738)3.03623348
25Focal seizures (HP:0007359)2.89428442
26Posterior subcapsular cataract (HP:0007787)2.87436623
27Pendular nystagmus (HP:0012043)2.86210072
28Congenital ichthyosiform erythroderma (HP:0007431)2.82592930
29Gingival bleeding (HP:0000225)2.81675995
30Rimmed vacuoles (HP:0003805)2.73583004
31Hyperlipoproteinemia (HP:0010980)2.70176881
32Atonic seizures (HP:0010819)2.69097823
33Dysdiadochokinesis (HP:0002075)2.68315767
34Myokymia (HP:0002411)2.66800468
35Progressive cerebellar ataxia (HP:0002073)2.61988735
36Right ventricular cardiomyopathy (HP:0011663)2.59824852
37Absence seizures (HP:0002121)2.59085443
38Exercise-induced muscle cramps (HP:0003710)2.57115310
39Polyphagia (HP:0002591)2.55676326
40Poikilocytosis (HP:0004447)2.52627592
41Febrile seizures (HP:0002373)2.47279508
42Type II diabetes mellitus (HP:0005978)2.46900697
43Vitreoretinal degeneration (HP:0000655)2.44930950
44Abolished electroretinogram (ERG) (HP:0000550)2.36683043
45Ventricular fibrillation (HP:0001663)2.36277149
46Type 1 muscle fiber predominance (HP:0003803)2.34428453
47Decreased central vision (HP:0007663)2.34277204
48Muscle hypertrophy of the lower extremities (HP:0008968)2.32711573
49Epistaxis (HP:0000421)2.31948822
50Macular degeneration (HP:0000608)2.31027559
51Choroideremia (HP:0001139)2.30884275
52Abnormality of the lower motor neuron (HP:0002366)2.25943555
53Hypoplastic labia majora (HP:0000059)2.25884937
54Hypoglycemic coma (HP:0001325)2.25813903
55Attenuation of retinal blood vessels (HP:0007843)2.25111744
56Genetic anticipation (HP:0003743)2.23884683
57Hamartoma of the eye (HP:0010568)2.23600569
58Labial hypoplasia (HP:0000066)2.23578443
59Intestinal atresia (HP:0011100)2.22551370
60Action tremor (HP:0002345)2.21739567
61Abnormality of nail color (HP:0100643)2.19454812
62Generalized tonic-clonic seizures (HP:0002069)2.18656201
63Conjunctival hamartoma (HP:0100780)2.15761326
64Alopecia of scalp (HP:0002293)2.13956317
65Hyporeflexia of lower limbs (HP:0002600)2.13490143
66Calf muscle hypertrophy (HP:0008981)2.13358704
67Abnormality of the axillary hair (HP:0100134)2.11928506
68Abnormality of secondary sexual hair (HP:0009888)2.11928506
69Dialeptic seizures (HP:0011146)2.11842014
70Optic nerve hypoplasia (HP:0000609)2.11066295
71Photophobia (HP:0000613)2.10815934
72Paralysis (HP:0003470)2.10814428
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09352787
74Parakeratosis (HP:0001036)2.08379668
75Hypotrichosis (HP:0001006)2.07606554
76Abnormality of the labia majora (HP:0012881)2.06013007
77Proximal tubulopathy (HP:0000114)2.05003178
78Depression (HP:0000716)2.04766038
79Papillary thyroid carcinoma (HP:0002895)2.04440541
80Increased corneal curvature (HP:0100692)2.03373245
81Keratoconus (HP:0000563)2.03373245
82Furrowed tongue (HP:0000221)2.01992741
83Hemiparesis (HP:0001269)2.01866049
84Megalencephaly (HP:0001355)2.01085121
85Dysmetric saccades (HP:0000641)1.98053999
86Palmoplantar keratoderma (HP:0000982)1.97324587
87Broad-based gait (HP:0002136)1.96969508
88Round ear (HP:0100830)1.96252603
89Hypoplastic female external genitalia (HP:0012815)1.96111813
90Abnormal auditory evoked potentials (HP:0006958)1.95882952
91Hyperventilation (HP:0002883)1.95491238
92Truncal ataxia (HP:0002078)1.95459010
93Abnormality of the labia minora (HP:0012880)1.95419236
94Drooling (HP:0002307)1.93859962
95Excessive salivation (HP:0003781)1.93859962
96Shoulder girdle muscle weakness (HP:0003547)1.93088185
97Medial flaring of the eyebrow (HP:0010747)1.93005458
98Hepatoblastoma (HP:0002884)1.92672872
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89108742
100Hypothermia (HP:0002045)1.89025696
101Intention tremor (HP:0002080)1.88516425
102Poor eye contact (HP:0000817)1.88483212
103Subcapsular cataract (HP:0000523)1.88468457
104Pancreatic islet-cell hyperplasia (HP:0004510)1.87984926
105Thick nail (HP:0001805)1.86780464
106Ankle clonus (HP:0011448)1.86587425
107Impaired social interactions (HP:0000735)1.85094265
108Abnormal social behavior (HP:0012433)1.85094265
109Abnormality of the renal cortex (HP:0011035)1.83301691
110Increased variability in muscle fiber diameter (HP:0003557)1.82998368
111Difficulty running (HP:0009046)1.82561909
112Fair hair (HP:0002286)1.82001370
113Sudden death (HP:0001699)1.81714776
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81518069
115Epileptiform EEG discharges (HP:0011182)1.81408028
116Plantar hyperkeratosis (HP:0007556)1.81205358
117Pancreatic cysts (HP:0001737)1.80541697
118Palmoplantar hyperkeratosis (HP:0000972)1.79261507
119EEG with generalized epileptiform discharges (HP:0011198)1.79065101
120Abnormal pupillary function (HP:0007686)1.78486380
121Muscle fiber splitting (HP:0003555)1.78064807
122Muscle fiber inclusion bodies (HP:0100299)1.77708590
123Pheochromocytoma (HP:0002666)1.75299104
124Mildly elevated creatine phosphokinase (HP:0008180)1.75206772
125Hypomagnesemia (HP:0002917)1.74400608
126Generalized hypopigmentation (HP:0007513)1.74200704
127Myoglobinuria (HP:0002913)1.72125588
128Overgrowth (HP:0001548)1.71781739
129Impaired vibration sensation in the lower limbs (HP:0002166)1.71750622
130Lissencephaly (HP:0001339)1.69174449
131Cone-rod dystrophy (HP:0000548)1.68628855
132Anxiety (HP:0000739)1.67116880
133Intellectual disability, profound (HP:0002187)1.66503374
134Hypsarrhythmia (HP:0002521)1.66414517
135Achilles tendon contracture (HP:0001771)1.66298635
136Gait imbalance (HP:0002141)1.66283651
137Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.66213920
138Prolonged QT interval (HP:0001657)1.65436394
139Hypohidrosis (HP:0000966)1.65429196
140Growth hormone deficiency (HP:0000824)1.65376185
141Onycholysis (HP:0001806)1.64566055
142True hermaphroditism (HP:0010459)1.64008398
143Erythema (HP:0010783)1.63286355
144Distal arthrogryposis (HP:0005684)1.62125973
145Genital tract atresia (HP:0001827)1.62116739
146Amelogenesis imperfecta (HP:0000705)1.61809961
147Palmar hyperkeratosis (HP:0010765)1.61799846
148Myopathic facies (HP:0002058)1.61728532
149Renal cortical cysts (HP:0000803)1.61695042
150Absent eyelashes (HP:0000561)1.61422617
151Syncope (HP:0001279)1.61351540
152Corneal erosion (HP:0200020)1.61159052
153Pancreatic fibrosis (HP:0100732)1.61121555
154Hypoventilation (HP:0002791)1.60580420
155Agitation (HP:0000713)1.60480018
156Myotonia (HP:0002486)1.60161298
157Absent speech (HP:0001344)1.60111178
158Aplasia of the phalanges of the hand (HP:0009802)1.60032784
159Aplasia involving bones of the extremities (HP:0009825)1.60032784
160Aplasia involving bones of the upper limbs (HP:0009823)1.60032784
161Curly hair (HP:0002212)1.58945473
162Severe Myopia (HP:0011003)1.58689920
163Woolly hair (HP:0002224)1.57487250
164Abnormality of the calf musculature (HP:0001430)1.57201258
165Amblyopia (HP:0000646)1.57199840
166Horizontal nystagmus (HP:0000666)1.56867078
167Thyroid carcinoma (HP:0002890)1.56832235
168Congenital primary aphakia (HP:0007707)1.54474628
169Delayed puberty (HP:0000823)1.54189150
170Biliary tract neoplasm (HP:0100574)1.53049036
171Widely spaced teeth (HP:0000687)1.52710118
172Abnormal platelet function (HP:0011869)1.52633717
173Impaired platelet aggregation (HP:0003540)1.52633717
174Taurodontia (HP:0000679)1.51864844
175Abnormality of permanent molar morphology (HP:0011071)1.51864844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.30160909
2MST43.18895773
3STK242.94845807
4STK38L2.87050642
5NTRK32.86394885
6MAP3K92.74613918
7EPHA42.74171773
8MAP4K22.71809904
9WNK32.66443940
10MAP3K42.66007020
11TRIM282.25743695
12TNIK2.22311088
13PRKD32.10463434
14MAP2K42.04927509
15PHKG12.00232003
16PHKG22.00232003
17MINK11.98884647
18STK31.98847202
19DAPK21.96644203
20NEK11.95900179
21ACVR1B1.92597541
22FER1.84086709
23CAMKK11.83321088
24LATS21.81758449
25PAK61.75205632
26CASK1.72147144
27MAP3K21.71473746
28PNCK1.67346110
29NTRK21.62120083
30MAP2K71.59424986
31MKNK21.55731330
32RIPK11.53226081
33TRIB31.52881940
34NTRK11.50968415
35PINK11.47167925
36FRK1.42458934
37BMPR1B1.40158121
38LATS11.38704041
39STK381.37045747
40CAMKK21.36718402
41KSR21.36598834
42BMX1.33652525
43PAK31.33574363
44PLK21.31712842
45ERBB31.27697300
46GRK11.22446403
47ZAK1.22364108
48OBSCN1.20057805
49INSRR1.19272254
50PDGFRA1.18818709
51ADRBK21.17637273
52PIK3CG1.17080986
53KSR11.16714743
54DDR21.16568299
55PTK2B1.16358656
56TAOK11.13154689
57CDK51.12412745
58NLK1.05009186
59NUAK11.02758645
60RET1.02719626
61TTN0.99433699
62PDK30.98782104
63PDK40.98782104
64AKT30.97770864
65EIF2AK10.93332815
66MYLK0.92952776
67TGFBR10.92463327
68MAP3K70.92452733
69PRKCG0.90987534
70BRSK20.89189817
71GRK50.88801275
72FGFR10.87157431
73SCYL20.86666086
74SGK20.86548607
75DYRK20.86009838
76SGK2230.85521897
77SGK4940.85521897
78PRKCH0.82986701
79FGR0.82869879
80SGK30.82529443
81YES10.82524146
82DYRK30.79394830
83PLK30.77714147
84DMPK0.77595381
85TYRO30.76849675
86FGFR30.75074133
87STK110.74857530
88PIK3CA0.74666895
89DAPK10.74405725
90MAPK130.74354594
91PKN20.74187127
92CAMK2A0.74104040
93MAP2K10.70519824
94FGFR20.70219726
95EPHB20.69657246
96PTK20.68618239
97PRPF4B0.67127526
98LMTK20.66877362
99DYRK1A0.65371563
100MAPK120.64803880
101CSNK1G10.64544392
102MAP3K10.62280416
103PTK60.62246444
104CDK140.61867300
105CDC42BPA0.61607908
106SGK10.61046709
107PRKAA10.59531877
108MAP3K120.59363046
109MKNK10.59161378
110MAPKAPK30.58690573
111ADRBK10.58201214
112ROCK10.57401560
113SIK10.56748561
114ILK0.56336758
115TEC0.56059534
116PRKCE0.55979670
117EPHA30.55106102
118CDK180.54437894
119RPS6KA30.54240089
120BCR0.53895640
121CSNK1G20.53725629
122CDK150.53592499
123STK160.52938230
124CAMK10.51886726
125TIE10.51839110
126PRKG10.51388840
127CAMK1G0.49815210
128PRKCZ0.49733392
129MAP3K60.48172174
130ALK0.47954349
131NME10.45431637
132CAMK2D0.44885107
133CDK190.44833501
134PRKAA20.44761206
135MARK20.44053112
136HIPK20.43142815
137PRKACA0.42354496
138CSNK1G30.42112403
139RPS6KA20.41684328
140CDK11A0.40979044
141PKN10.40038143
142SIK30.39043421
143IRAK20.38075465
144TRPM70.37679579
145OXSR10.37042873
146IRAK10.34501291
147PRKACG0.33342842
148CSNK1D0.32854401
149MAP2K60.31920608
150PRKACB0.30122682
151CSNK1A1L0.29955668

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.06146231
2Synaptic vesicle cycle_Homo sapiens_hsa047212.74311197
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42276467
4Nicotine addiction_Homo sapiens_hsa050332.36537797
5Fatty acid elongation_Homo sapiens_hsa000622.27450069
6GABAergic synapse_Homo sapiens_hsa047272.23607630
7Linoleic acid metabolism_Homo sapiens_hsa005912.15837293
8Circadian entrainment_Homo sapiens_hsa047132.15669389
9Olfactory transduction_Homo sapiens_hsa047402.10731358
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99849574
11Platelet activation_Homo sapiens_hsa046111.97807682
12Insulin secretion_Homo sapiens_hsa049111.95060663
13Long-term potentiation_Homo sapiens_hsa047201.94064861
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89093341
15Dopaminergic synapse_Homo sapiens_hsa047281.82420921
16Glutamatergic synapse_Homo sapiens_hsa047241.79528226
17Morphine addiction_Homo sapiens_hsa050321.76374597
18Amphetamine addiction_Homo sapiens_hsa050311.74983219
19Cholinergic synapse_Homo sapiens_hsa047251.64938095
20Arachidonic acid metabolism_Homo sapiens_hsa005901.63827156
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59593813
22Ether lipid metabolism_Homo sapiens_hsa005651.55629457
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54017147
24Salivary secretion_Homo sapiens_hsa049701.52128707
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51549663
26Steroid biosynthesis_Homo sapiens_hsa001001.50704743
27Renin secretion_Homo sapiens_hsa049241.49142658
28Oxytocin signaling pathway_Homo sapiens_hsa049211.48636711
29Gastric acid secretion_Homo sapiens_hsa049711.45871696
30Circadian rhythm_Homo sapiens_hsa047101.39229090
31Sphingolipid metabolism_Homo sapiens_hsa006001.37953598
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37023787
33Nitrogen metabolism_Homo sapiens_hsa009101.36016565
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32126121
35Propanoate metabolism_Homo sapiens_hsa006401.30676409
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.28616083
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28485844
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27268233
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27069237
40Serotonergic synapse_Homo sapiens_hsa047261.25774535
41Long-term depression_Homo sapiens_hsa047301.24437629
42GnRH signaling pathway_Homo sapiens_hsa049121.21326575
43Dilated cardiomyopathy_Homo sapiens_hsa054141.20195479
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19789126
45Cocaine addiction_Homo sapiens_hsa050301.19515720
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18359644
47beta-Alanine metabolism_Homo sapiens_hsa004101.15125662
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14542495
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14502669
50Type II diabetes mellitus_Homo sapiens_hsa049301.14106129
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13836519
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13818502
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13783761
54Calcium signaling pathway_Homo sapiens_hsa040201.12889054
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11456753
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11247645
57Taste transduction_Homo sapiens_hsa047421.09434797
58Gap junction_Homo sapiens_hsa045401.08065094
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02833356
60Arginine and proline metabolism_Homo sapiens_hsa003301.01731973
61Estrogen signaling pathway_Homo sapiens_hsa049151.01585958
62Glioma_Homo sapiens_hsa052141.01429932
63Glucagon signaling pathway_Homo sapiens_hsa049221.01040670
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98684329
65Fat digestion and absorption_Homo sapiens_hsa049750.98049038
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97771033
67Starch and sucrose metabolism_Homo sapiens_hsa005000.97451703
68cAMP signaling pathway_Homo sapiens_hsa040240.95619523
69Melanogenesis_Homo sapiens_hsa049160.94814786
70Axon guidance_Homo sapiens_hsa043600.94694897
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92999339
72Collecting duct acid secretion_Homo sapiens_hsa049660.91991909
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.90996244
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89083098
75mTOR signaling pathway_Homo sapiens_hsa041500.88750084
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86788518
77Retinol metabolism_Homo sapiens_hsa008300.86388637
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85605370
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84979238
80Histidine metabolism_Homo sapiens_hsa003400.84911584
81Vibrio cholerae infection_Homo sapiens_hsa051100.84422256
82Sulfur metabolism_Homo sapiens_hsa009200.84233589
83Pancreatic secretion_Homo sapiens_hsa049720.83489625
84ErbB signaling pathway_Homo sapiens_hsa040120.80829782
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78420156
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76118461
87Fatty acid degradation_Homo sapiens_hsa000710.75723943
88Endometrial cancer_Homo sapiens_hsa052130.73252207
89Cardiac muscle contraction_Homo sapiens_hsa042600.72920776
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72578637
91ABC transporters_Homo sapiens_hsa020100.72107235
92Insulin signaling pathway_Homo sapiens_hsa049100.71242224
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.70955621
94Fatty acid metabolism_Homo sapiens_hsa012120.70828583
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.70663252
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68487032
97Tight junction_Homo sapiens_hsa045300.67440608
98Thyroid hormone synthesis_Homo sapiens_hsa049180.67246075
99Glutathione metabolism_Homo sapiens_hsa004800.66314599
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66198340
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.65412595
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65154763
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65105461
104Peroxisome_Homo sapiens_hsa041460.65033626
105Tryptophan metabolism_Homo sapiens_hsa003800.64968172
106Glycerolipid metabolism_Homo sapiens_hsa005610.64745684
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62883484
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.61729992
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61053017
110Bile secretion_Homo sapiens_hsa049760.59996818
111Selenocompound metabolism_Homo sapiens_hsa004500.59597226
112Hippo signaling pathway_Homo sapiens_hsa043900.59217047
113Insulin resistance_Homo sapiens_hsa049310.57161834
114Dorso-ventral axis formation_Homo sapiens_hsa043200.56454414
115Renal cell carcinoma_Homo sapiens_hsa052110.56450061
116Oocyte meiosis_Homo sapiens_hsa041140.56384836
117VEGF signaling pathway_Homo sapiens_hsa043700.55626445
118Regulation of autophagy_Homo sapiens_hsa041400.55592228
119Oxidative phosphorylation_Homo sapiens_hsa001900.54544735
120Focal adhesion_Homo sapiens_hsa045100.53676721
121Ras signaling pathway_Homo sapiens_hsa040140.53375798
122MAPK signaling pathway_Homo sapiens_hsa040100.53227279
123AMPK signaling pathway_Homo sapiens_hsa041520.52681849
124Wnt signaling pathway_Homo sapiens_hsa043100.52049981
125Chemical carcinogenesis_Homo sapiens_hsa052040.51872867
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51073057
127Fatty acid biosynthesis_Homo sapiens_hsa000610.50914338
128Protein export_Homo sapiens_hsa030600.50301952
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49548721
130Butanoate metabolism_Homo sapiens_hsa006500.48992626
131Basal transcription factors_Homo sapiens_hsa030220.47916497
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.47117898
133Rap1 signaling pathway_Homo sapiens_hsa040150.47112663
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46829210
135Arginine biosynthesis_Homo sapiens_hsa002200.46779625
136Choline metabolism in cancer_Homo sapiens_hsa052310.45242969
137Adherens junction_Homo sapiens_hsa045200.44490087
138Proteoglycans in cancer_Homo sapiens_hsa052050.41519802
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.40756277
140Ovarian steroidogenesis_Homo sapiens_hsa049130.39410648
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38377123
142Hedgehog signaling pathway_Homo sapiens_hsa043400.38137501
143Endocytosis_Homo sapiens_hsa041440.37951349
144Protein digestion and absorption_Homo sapiens_hsa049740.37886369
145Inositol phosphate metabolism_Homo sapiens_hsa005620.37275788
146Bladder cancer_Homo sapiens_hsa052190.37257285
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36585322
148ECM-receptor interaction_Homo sapiens_hsa045120.35218984

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