LGI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.90837457
2vocalization behavior (GO:0071625)5.65283285
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63169485
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.52940167
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.28725351
6synaptic vesicle exocytosis (GO:0016079)5.24425101
7presynaptic membrane assembly (GO:0097105)5.23620863
8neuron cell-cell adhesion (GO:0007158)5.18449662
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.07356943
10regulation of glutamate receptor signaling pathway (GO:1900449)5.06616303
11protein localization to synapse (GO:0035418)5.06459980
12neurotransmitter-gated ion channel clustering (GO:0072578)5.05878719
13presynaptic membrane organization (GO:0097090)5.01818035
14neuronal action potential propagation (GO:0019227)4.99722595
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.89598388
16glutamate receptor signaling pathway (GO:0007215)4.86813032
17glutamate secretion (GO:0014047)4.86736159
18locomotory exploration behavior (GO:0035641)4.80371136
19synaptic transmission, glutamatergic (GO:0035249)4.76396257
20regulation of synaptic vesicle exocytosis (GO:2000300)4.63158066
21synaptic vesicle maturation (GO:0016188)4.57509905
22neuron-neuron synaptic transmission (GO:0007270)4.52960809
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.45561907
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44841007
25postsynaptic membrane organization (GO:0001941)4.40014165
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24713748
27regulation of synaptic vesicle transport (GO:1902803)4.24084458
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.20326703
29positive regulation of meiosis (GO:0045836)4.19588876
30regulation of neuronal synaptic plasticity (GO:0048168)4.19447383
31behavioral response to nicotine (GO:0035095)4.09777437
32sphingosine metabolic process (GO:0006670)4.06621873
33neurotransmitter secretion (GO:0007269)4.06266511
34gamma-aminobutyric acid signaling pathway (GO:0007214)4.04689119
35exploration behavior (GO:0035640)4.02620435
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97626407
37regulation of postsynaptic membrane potential (GO:0060078)3.95305664
38positive regulation of membrane potential (GO:0045838)3.94889652
39diol metabolic process (GO:0034311)3.92867903
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.92852955
41positive regulation of meiotic cell cycle (GO:0051446)3.88699328
42long-term memory (GO:0007616)3.85798348
43positive regulation of synapse maturation (GO:0090129)3.82701567
44sphingoid metabolic process (GO:0046519)3.77071572
45response to histamine (GO:0034776)3.76419562
46gamma-aminobutyric acid transport (GO:0015812)3.71272712
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.70512106
48long-term synaptic potentiation (GO:0060291)3.70442664
49regulation of synaptic plasticity (GO:0048167)3.65319890
50regulation of meiosis I (GO:0060631)3.59940324
51transmission of nerve impulse (GO:0019226)3.56934890
52startle response (GO:0001964)3.54603654
53positive regulation of neurotransmitter secretion (GO:0001956)3.51121851
54neuron recognition (GO:0008038)3.49409232
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48488181
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47200572
57regulation of synapse structural plasticity (GO:0051823)3.46655042
58neurotransmitter transport (GO:0006836)3.42946809
59behavioral fear response (GO:0001662)3.40565143
60behavioral defense response (GO:0002209)3.40565143
61cerebellar granule cell differentiation (GO:0021707)3.40351440
62regulation of neurotransmitter secretion (GO:0046928)3.40203594
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38053017
64membrane depolarization (GO:0051899)3.37915475
65DNA methylation involved in gamete generation (GO:0043046)3.36846139
66positive regulation of synapse assembly (GO:0051965)3.36495478
67regulation of synapse maturation (GO:0090128)3.34898223
68regulation of glutamate secretion (GO:0014048)3.33856446
69epithelial cilium movement (GO:0003351)3.33502875
70serotonin receptor signaling pathway (GO:0007210)3.32784446
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32695520
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31418049
73proline transport (GO:0015824)3.30129375
74synaptic vesicle endocytosis (GO:0048488)3.24478657
75learning (GO:0007612)3.22820436
76regulation of dendritic spine morphogenesis (GO:0061001)3.22780559
77regulation of vesicle fusion (GO:0031338)3.21943017
78fear response (GO:0042596)3.21328056
79cellular potassium ion homeostasis (GO:0030007)3.21070730
80dendritic spine morphogenesis (GO:0060997)3.18584125
81cerebellar Purkinje cell differentiation (GO:0021702)3.18305070
82membrane depolarization during action potential (GO:0086010)3.17858032
83auditory behavior (GO:0031223)3.17657974
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17442084
85positive regulation of neurotransmitter transport (GO:0051590)3.17370279
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14837941
87serotonin metabolic process (GO:0042428)3.14675659
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13033305
89regulation of neurotransmitter levels (GO:0001505)3.12884160
90mechanosensory behavior (GO:0007638)3.12473085
91regulation of neurotransmitter transport (GO:0051588)3.11147490
92synaptic transmission (GO:0007268)3.10096618
93axonal fasciculation (GO:0007413)3.07355940
94regulation of synaptic transmission, GABAergic (GO:0032228)3.06668435
95negative regulation of amino acid transport (GO:0051956)3.06069922
96* regulation of synaptic transmission (GO:0050804)3.04278490
97detection of calcium ion (GO:0005513)3.04235297
98protein-chromophore linkage (GO:0018298)3.01904854
99response to auditory stimulus (GO:0010996)3.01215777
100synapse assembly (GO:0007416)3.00980267
101innervation (GO:0060384)3.00821958
102behavioral response to cocaine (GO:0048148)3.00435734
103limb bud formation (GO:0060174)2.99298242
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99097778
105membrane hyperpolarization (GO:0060081)2.98084469
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97403801
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.97149113
108* positive regulation of synaptic transmission (GO:0050806)2.96707311
109C4-dicarboxylate transport (GO:0015740)2.95560815
110cilium movement (GO:0003341)2.94469501
111regulation of synapse assembly (GO:0051963)2.93561331
112regulation of dendritic spine development (GO:0060998)2.92908009
113primary amino compound metabolic process (GO:1901160)2.91077769
114piRNA metabolic process (GO:0034587)2.90766884
115positive regulation of dendritic spine development (GO:0060999)2.90424896
116negative regulation of dendrite morphogenesis (GO:0050774)2.90119192
117central nervous system myelination (GO:0022010)2.89669837
118axon ensheathment in central nervous system (GO:0032291)2.89669837
119sulfation (GO:0051923)2.88686928
120regulation of respiratory system process (GO:0044065)2.86651306
121female mating behavior (GO:0060180)2.85311253
122regulation of rhodopsin mediated signaling pathway (GO:0022400)2.85259141
123regulation of female receptivity (GO:0045924)2.84545002
124regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.83753552
125nonmotile primary cilium assembly (GO:0035058)2.83287333
126centriole replication (GO:0007099)2.80981037
127retinal ganglion cell axon guidance (GO:0031290)2.71185276
128intraciliary transport (GO:0042073)2.70683217
129regulation of pigment cell differentiation (GO:0050932)2.70489580
130sulfate transmembrane transport (GO:1902358)2.69087296
131rhodopsin mediated signaling pathway (GO:0016056)2.66657912
132epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66460539
133negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.65077977
134otic vesicle formation (GO:0030916)2.57591328
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56801526
136regulation of protein glycosylation (GO:0060049)2.55921559
137cilium organization (GO:0044782)2.54200244
138neuromuscular synaptic transmission (GO:0007274)2.53874170
139mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53648495
140regulation of neurotransmitter uptake (GO:0051580)2.51766037
141retinal cone cell development (GO:0046549)2.51573837
142cilium assembly (GO:0042384)2.51518248
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50523592
144somite development (GO:0061053)2.50332952
145positive regulation of developmental pigmentation (GO:0048087)2.49504960
146potassium ion transmembrane transport (GO:0071805)2.48646537
147cellular potassium ion transport (GO:0071804)2.48646537
148L-fucose catabolic process (GO:0042355)2.48142328
149fucose catabolic process (GO:0019317)2.48142328
150L-fucose metabolic process (GO:0042354)2.48142328
151negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47761891
152protein localization to cilium (GO:0061512)2.45763968
153somite rostral/caudal axis specification (GO:0032525)2.43714712
154reflex (GO:0060004)2.42780110
155midbrain development (GO:0030901)2.42683903
156protein polyglutamylation (GO:0018095)2.41541065
157notochord development (GO:0030903)2.41314521
158energy coupled proton transport, down electrochemical gradient (GO:0015985)2.40973804
159ATP synthesis coupled proton transport (GO:0015986)2.40973804
160cilium morphogenesis (GO:0060271)2.40451246
161behavioral response to ethanol (GO:0048149)2.39155293
162neurotransmitter uptake (GO:0001504)2.36629571
163sulfate transport (GO:0008272)2.36148074
164neuronal action potential (GO:0019228)2.35938385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45612683
2GBX2_23144817_ChIP-Seq_PC3_Human4.38518961
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12618993
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05978621
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05572734
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67004872
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59103521
8REST_21632747_ChIP-Seq_MESCs_Mouse2.58462601
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56923079
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56913804
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56913804
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.49548474
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45518850
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.44416611
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34142947
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32908727
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32156490
18TAF15_26573619_Chip-Seq_HEK293_Human2.21298277
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.10425739
20DROSHA_22980978_ChIP-Seq_HELA_Human2.09626351
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.09494845
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09422031
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.09025477
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08465349
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08209853
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.01038777
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96307350
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95505634
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92548643
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91541367
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89980607
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.86494716
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84751860
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83517647
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82275241
36AR_21572438_ChIP-Seq_LNCaP_Human1.78077734
37* P300_19829295_ChIP-Seq_ESCs_Human1.77724607
38EWS_26573619_Chip-Seq_HEK293_Human1.66676024
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66489003
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65679791
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63544430
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61875777
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.58146672
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56839027
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.56724464
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52991040
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49125728
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43945866
49AR_25329375_ChIP-Seq_VCAP_Human1.43569328
50FUS_26573619_Chip-Seq_HEK293_Human1.42015774
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41914444
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41154409
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40394234
54* PIAS1_25552417_ChIP-Seq_VCAP_Human1.40348291
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38697418
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38000764
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.37957721
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35311510
59RNF2_27304074_Chip-Seq_NSC_Mouse1.35127065
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34453148
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33963443
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33885859
63STAT3_23295773_ChIP-Seq_U87_Human1.32549191
64IGF1R_20145208_ChIP-Seq_DFB_Human1.29817747
65VDR_22108803_ChIP-Seq_LS180_Human1.29758997
66ZNF274_21170338_ChIP-Seq_K562_Hela1.27612312
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27264187
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.26271761
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25073909
70SOX2_19829295_ChIP-Seq_ESCs_Human1.24568086
71NANOG_19829295_ChIP-Seq_ESCs_Human1.24568086
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24430263
73TCF4_23295773_ChIP-Seq_U87_Human1.21456806
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.20264049
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19840911
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18397354
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17352352
78CBP_20019798_ChIP-Seq_JUKART_Human1.16885729
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16885729
80TCF4_22108803_ChIP-Seq_LS180_Human1.16801603
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16260169
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15692529
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.14930229
84* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14724003
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.12100524
86RUNX2_22187159_ChIP-Seq_PCA_Human1.12000741
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11478040
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.11236237
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.11121617
90ER_23166858_ChIP-Seq_MCF-7_Human1.11046795
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.10126028
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.09387489
93AR_19668381_ChIP-Seq_PC3_Human1.08404048
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.07988284
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.07407848
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07186789
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06705225
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06688285
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.06524208
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.06044968
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05820780
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05771980
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05659706
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04550421
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04436282
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04281579
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03380453
108P53_22387025_ChIP-Seq_ESCs_Mouse1.03130236
109JUN_21703547_ChIP-Seq_K562_Human1.02994847
110* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02945066
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02252856
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01385902
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01384384
114TP53_18474530_ChIP-ChIP_U2OS_Human1.00534589
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00245194
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00078087
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99706595
118AHR_22903824_ChIP-Seq_MCF-7_Human0.98443012
119BCAT_22108803_ChIP-Seq_LS180_Human0.97903003
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.97460734
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96287254
122* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95962530
123* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95054105
124* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95054105
125TP53_16413492_ChIP-PET_HCT116_Human0.93394394
126KDM2B_26808549_Chip-Seq_REH_Human0.91651867
127RXR_22108803_ChIP-Seq_LS180_Human0.91634414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.99360984
2MP0003880_abnormal_central_pattern5.40631864
3* MP0003635_abnormal_synaptic_transmissio4.02829144
4MP0002653_abnormal_ependyma_morphology3.74772744
5* MP0009745_abnormal_behavioral_response3.54856397
6MP0004270_analgesia3.45860323
7MP0001968_abnormal_touch/_nociception3.36126938
8MP0002063_abnormal_learning/memory/cond3.23610691
9* MP0002064_seizures3.17627955
10MP0009046_muscle_twitch3.11884906
11MP0002572_abnormal_emotion/affect_behav2.90237373
12MP0002822_catalepsy2.84731653
13MP0002735_abnormal_chemical_nociception2.82935200
14MP0002736_abnormal_nociception_after2.78118994
15MP0002272_abnormal_nervous_system2.71011565
16MP0001486_abnormal_startle_reflex2.59467632
17MP0002734_abnormal_mechanical_nocicepti2.58513709
18MP0000566_synostosis2.55468396
19MP0002938_white_spotting2.47210558
20MP0001501_abnormal_sleep_pattern2.36277192
21MP0003890_abnormal_embryonic-extraembry2.31385948
22MP0005423_abnormal_somatic_nervous2.30346099
23MP0001188_hyperpigmentation2.25470441
24MP0001440_abnormal_grooming_behavior2.22599614
25MP0002067_abnormal_sensory_capabilities2.17545296
26MP0002733_abnormal_thermal_nociception2.03787837
27MP0001970_abnormal_pain_threshold2.01217075
28MP0005646_abnormal_pituitary_gland1.96846241
29MP0003646_muscle_fatigue1.90649727
30MP0006276_abnormal_autonomic_nervous1.84884529
31MP0008569_lethality_at_weaning1.84803738
32MP0002557_abnormal_social/conspecific_i1.79562520
33MP0002184_abnormal_innervation1.76198008
34MP0003879_abnormal_hair_cell1.72510193
35MP0003787_abnormal_imprinting1.71815118
36MP0009780_abnormal_chondrocyte_physiolo1.67709301
37MP0001984_abnormal_olfaction1.66946331
38MP0004924_abnormal_behavior1.65550246
39MP0005386_behavior/neurological_phenoty1.65550246
40MP0000778_abnormal_nervous_system1.65518381
41MP0002102_abnormal_ear_morphology1.64817485
42MP0001905_abnormal_dopamine_level1.59295200
43MP0004147_increased_porphyrin_level1.55981736
44MP0002234_abnormal_pharynx_morphology1.49314525
45MP0001529_abnormal_vocalization1.48289323
46MP0004142_abnormal_muscle_tone1.45834786
47MP0004811_abnormal_neuron_physiology1.45238857
48MP0003283_abnormal_digestive_organ1.42343485
49MP0001502_abnormal_circadian_rhythm1.41120378
50MP0002909_abnormal_adrenal_gland1.40324070
51MP0005645_abnormal_hypothalamus_physiol1.38916110
52MP0000955_abnormal_spinal_cord1.34086386
53MP0002066_abnormal_motor_capabilities/c1.33583358
54MP0002882_abnormal_neuron_morphology1.32041831
55MP0006072_abnormal_retinal_apoptosis1.31878563
56MP0003195_calcinosis1.30809676
57MP0004858_abnormal_nervous_system1.29420416
58MP0003633_abnormal_nervous_system1.28867304
59MP0004133_heterotaxia1.27942652
60MP0003011_delayed_dark_adaptation1.25364371
61MP0003329_amyloid_beta_deposits1.24594867
62MP0003045_fibrosis1.21912834
63MP0005253_abnormal_eye_physiology1.21270806
64MP0006292_abnormal_olfactory_placode1.20634521
65MP0003937_abnormal_limbs/digits/tail_de1.17718729
66MP0005409_darkened_coat_color1.17551393
67MP0002876_abnormal_thyroid_physiology1.17180994
68MP0004885_abnormal_endolymph1.16740778
69MP0010030_abnormal_orbit_morphology1.14049771
70MP0010386_abnormal_urinary_bladder1.13563574
71MP0003122_maternal_imprinting1.10251302
72MP0008789_abnormal_olfactory_epithelium1.08722306
73MP0008877_abnormal_DNA_methylation1.08208315
74MP0003631_nervous_system_phenotype1.07622654
75MP0004145_abnormal_muscle_electrophysio1.03689527
76MP0001963_abnormal_hearing_physiology1.01755345
77MP0004742_abnormal_vestibular_system1.01282165
78MP0001986_abnormal_taste_sensitivity1.00465346
79MP0001293_anophthalmia1.00124708
80MP0002095_abnormal_skin_pigmentation0.99755056
81MP0002152_abnormal_brain_morphology0.95362409
82MP0005551_abnormal_eye_electrophysiolog0.94533641
83MP0005075_abnormal_melanosome_morpholog0.94184628
84MP0002837_dystrophic_cardiac_calcinosis0.93750719
85MP0005174_abnormal_tail_pigmentation0.93252470
86MP0003121_genomic_imprinting0.93030490
87MP0000049_abnormal_middle_ear0.92117605
88MP0000427_abnormal_hair_cycle0.91224510
89MP0002160_abnormal_reproductive_system0.90942927
90MP0002229_neurodegeneration0.89983233
91MP0002638_abnormal_pupillary_reflex0.89710691
92MP0002069_abnormal_eating/drinking_beha0.89642354
93MP0000383_abnormal_hair_follicle0.87815769
94MP0001485_abnormal_pinna_reflex0.86988762
95MP0001346_abnormal_lacrimal_gland0.86864603
96MP0003136_yellow_coat_color0.86830490
97MP0003183_abnormal_peptide_metabolism0.86722342
98MP0005377_hearing/vestibular/ear_phenot0.86241154
99MP0003878_abnormal_ear_physiology0.86241154
100MP0008874_decreased_physiological_sensi0.86177389
101MP0001664_abnormal_digestion0.84223743
102MP0000372_irregular_coat_pigmentation0.82414702
103MP0005195_abnormal_posterior_eye0.82031707
104MP0000015_abnormal_ear_pigmentation0.80915833
105MP0008872_abnormal_physiological_respon0.80411380
106MP0005535_abnormal_body_temperature0.79552257
107MP0002233_abnormal_nose_morphology0.78870213
108MP0000749_muscle_degeneration0.78427684
109MP0000631_abnormal_neuroendocrine_gland0.77182917
110MP0002752_abnormal_somatic_nervous0.76293837
111MP0004085_abnormal_heartbeat0.75174574
112MP0004484_altered_response_of0.74388548
113MP0001177_atelectasis0.72800619
114MP0004043_abnormal_pH_regulation0.72698724
115MP0004215_abnormal_myocardial_fiber0.70583571
116MP0005499_abnormal_olfactory_system0.70522759
117MP0005394_taste/olfaction_phenotype0.70522759
118MP0000026_abnormal_inner_ear0.70399516
119MP0000751_myopathy0.68512908
120MP0003632_abnormal_nervous_system0.67364260
121MP0000569_abnormal_digit_pigmentation0.64278133
122MP0003634_abnormal_glial_cell0.63504420
123MP0003690_abnormal_glial_cell0.63281540
124MP0005379_endocrine/exocrine_gland_phen0.61698298
125MP0002751_abnormal_autonomic_nervous0.58057956
126MP0003075_altered_response_to0.56698856
127MP0000013_abnormal_adipose_tissue0.55114299
128MP0000920_abnormal_myelination0.53559057
129MP0001943_abnormal_respiration0.50524885
130MP0003137_abnormal_impulse_conducting0.49610169
131MP0001765_abnormal_ion_homeostasis0.47432455
132* MP0010770_preweaning_lethality0.44717724
133* MP0002082_postnatal_lethality0.44717724
134* MP0010769_abnormal_survival0.44647449
135MP0003938_abnormal_ear_development0.44387060

Predicted human phenotypes

RankGene SetZ-score
1* Focal motor seizures (HP:0011153)8.33889874
2Myokymia (HP:0002411)5.99453142
3Epileptic encephalopathy (HP:0200134)5.80451973
4Febrile seizures (HP:0002373)5.54203103
5Atonic seizures (HP:0010819)5.52260709
6* Focal seizures (HP:0007359)5.49526608
7Visual hallucinations (HP:0002367)4.91053375
8Hyperventilation (HP:0002883)4.76162950
9Absence seizures (HP:0002121)4.48329799
10Progressive cerebellar ataxia (HP:0002073)4.37484356
11Pancreatic cysts (HP:0001737)4.32582964
12Generalized tonic-clonic seizures (HP:0002069)3.98854539
13Broad-based gait (HP:0002136)3.95330430
14Gaze-evoked nystagmus (HP:0000640)3.95100607
15Nephronophthisis (HP:0000090)3.80936076
16True hermaphroditism (HP:0010459)3.79625282
17* Dialeptic seizures (HP:0011146)3.78329189
18Pancreatic fibrosis (HP:0100732)3.73006034
19Colon cancer (HP:0003003)3.60058634
20Abnormality of midbrain morphology (HP:0002418)3.54277017
21Molar tooth sign on MRI (HP:0002419)3.54277017
22Action tremor (HP:0002345)3.31311532
23Abnormality of the renal medulla (HP:0100957)3.24634679
24Amblyopia (HP:0000646)3.19823418
25Dysdiadochokinesis (HP:0002075)3.06656952
26Amelogenesis imperfecta (HP:0000705)3.03363981
27Truncal ataxia (HP:0002078)2.96815459
28Poor eye contact (HP:0000817)2.92855923
29Abnormal eating behavior (HP:0100738)2.90843198
30Dysmetria (HP:0001310)2.88441480
31Absent speech (HP:0001344)2.85010169
32Cystic liver disease (HP:0006706)2.84630348
33Impaired vibration sensation in the lower limbs (HP:0002166)2.83661613
34Anxiety (HP:0000739)2.82199072
35Depression (HP:0000716)2.80933633
36Congenital stationary night blindness (HP:0007642)2.78319597
37Abnormality of the renal cortex (HP:0011035)2.74268875
38Excessive salivation (HP:0003781)2.71838453
39Drooling (HP:0002307)2.71838453
40Epileptiform EEG discharges (HP:0011182)2.68918859
41Protruding tongue (HP:0010808)2.66581177
42Inability to walk (HP:0002540)2.66051151
43Hemiparesis (HP:0001269)2.60498739
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.58938074
45Progressive inability to walk (HP:0002505)2.58160625
46Scanning speech (HP:0002168)2.57788250
47Abnormality of binocular vision (HP:0011514)2.54646556
48Diplopia (HP:0000651)2.54646556
49Concave nail (HP:0001598)2.52250097
50Impaired smooth pursuit (HP:0007772)2.52026784
51Abnormal social behavior (HP:0012433)2.49370738
52Impaired social interactions (HP:0000735)2.49370738
53Chronic hepatic failure (HP:0100626)2.48250615
54Fetal akinesia sequence (HP:0001989)2.47341040
55Blue irides (HP:0000635)2.43873026
56Supranuclear gaze palsy (HP:0000605)2.41682365
57Gait imbalance (HP:0002141)2.41586515
58Limb dystonia (HP:0002451)2.40573554
59Postural instability (HP:0002172)2.36449365
60EEG with generalized epileptiform discharges (HP:0011198)2.36248986
61Type II lissencephaly (HP:0007260)2.35704569
62Bradykinesia (HP:0002067)2.34963547
63Ankle clonus (HP:0011448)2.34113544
64Pendular nystagmus (HP:0012043)2.34097408
65Urinary bladder sphincter dysfunction (HP:0002839)2.34041049
66Abnormal respiratory motile cilium physiology (HP:0012261)2.33352388
67Abnormality of the labia minora (HP:0012880)2.32448516
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.30399316
69Absent/shortened dynein arms (HP:0200106)2.28354279
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.28354279
71Stereotypic behavior (HP:0000733)2.26073360
72Genetic anticipation (HP:0003743)2.26039746
73Parakeratosis (HP:0001036)2.25395873
74Polydipsia (HP:0001959)2.24063004
75Abnormal drinking behavior (HP:0030082)2.24063004
76Medial flaring of the eyebrow (HP:0010747)2.23615118
77Tubular atrophy (HP:0000092)2.22658789
78Congenital primary aphakia (HP:0007707)2.19110936
79Anencephaly (HP:0002323)2.18932812
80Congenital, generalized hypertrichosis (HP:0004540)2.18731689
81Hypsarrhythmia (HP:0002521)2.18174591
82Impaired vibratory sensation (HP:0002495)2.16861680
83Dysmetric saccades (HP:0000641)2.16694510
84Abnormality of ocular smooth pursuit (HP:0000617)2.14204079
85Pheochromocytoma (HP:0002666)2.14098359
86Congenital hepatic fibrosis (HP:0002612)2.13904287
87Abnormal respiratory motile cilium morphology (HP:0005938)2.12622754
88Abnormal respiratory epithelium morphology (HP:0012253)2.12622754
89Polyphagia (HP:0002591)2.12277599
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.11725867
91Nephrogenic diabetes insipidus (HP:0009806)2.11049261
92Retinal dysplasia (HP:0007973)2.09966604
93Acute necrotizing encephalopathy (HP:0006965)2.08872300
94Status epilepticus (HP:0002133)2.08675437
95Thickened helices (HP:0000391)2.08400301
96Optic nerve hypoplasia (HP:0000609)2.05768221
97Neuroendocrine neoplasm (HP:0100634)2.05596925
98Stomach cancer (HP:0012126)2.05465909
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04953820
100Generalized myoclonic seizures (HP:0002123)2.03723538
101Sclerocornea (HP:0000647)2.02495829
102Increased corneal curvature (HP:0100692)2.02289439
103Keratoconus (HP:0000563)2.02289439
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.02080222
105Oligodactyly (hands) (HP:0001180)2.02051435
106Generalized hypopigmentation of hair (HP:0011358)2.01503852
107Mitochondrial inheritance (HP:0001427)1.99897673
108Gait ataxia (HP:0002066)1.98050811
109Hemiplegia (HP:0002301)1.95251670
110Abnormality of salivation (HP:0100755)1.95033557
111Focal dystonia (HP:0004373)1.94214736
112Abnormal hair whorl (HP:0010721)1.93173889
113Torticollis (HP:0000473)1.91221873
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90839197
115Mutism (HP:0002300)1.90540599
116Fair hair (HP:0002286)1.89595612
117Postaxial foot polydactyly (HP:0001830)1.88782780
1183-Methylglutaconic aciduria (HP:0003535)1.88745304
119Poor coordination (HP:0002370)1.88624216
120Agitation (HP:0000713)1.88576701
121Specific learning disability (HP:0001328)1.88320569
122Acute encephalopathy (HP:0006846)1.87953483
123Postaxial hand polydactyly (HP:0001162)1.87759864
124Septo-optic dysplasia (HP:0100842)1.84372434
125Hepatocellular necrosis (HP:0001404)1.84100758
126Spastic gait (HP:0002064)1.81289332
127Progressive macrocephaly (HP:0004481)1.80855725
128Increased CSF lactate (HP:0002490)1.80552339
129Hypothermia (HP:0002045)1.80488641
130Papilledema (HP:0001085)1.79368528
131Abolished electroretinogram (ERG) (HP:0000550)1.78742288
132Abnormal ciliary motility (HP:0012262)1.78701196
133Bradycardia (HP:0001662)1.77939579
134Widely spaced teeth (HP:0000687)1.77398956
135Rhinitis (HP:0012384)1.76614662
136Cerebellar dysplasia (HP:0007033)1.76572511
137Genital tract atresia (HP:0001827)1.76300839
138Split foot (HP:0001839)1.75453206
139Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75151378
140Male pseudohermaphroditism (HP:0000037)1.75081330
141Esotropia (HP:0000565)1.75047065
142Decreased central vision (HP:0007663)1.74500232
143Preaxial hand polydactyly (HP:0001177)1.74349306
144Decreased circulating renin level (HP:0003351)1.74341752
145Psychosis (HP:0000709)1.72975235
146* Incomplete penetrance (HP:0003829)1.72703469
147Vaginal atresia (HP:0000148)1.72480407
148Hypoplasia of the pons (HP:0012110)1.71653925
149Poor suck (HP:0002033)1.71449103
150Limb ataxia (HP:0002070)1.71089092
151Anophthalmia (HP:0000528)1.71036369
152Abnormality of macular pigmentation (HP:0008002)1.70282279
153Attenuation of retinal blood vessels (HP:0007843)1.70276833
154Retinitis pigmentosa (HP:0000510)1.69633074
155Megalencephaly (HP:0001355)1.69070696
156Occipital encephalocele (HP:0002085)1.68704000
157Delusions (HP:0000746)1.67842576
158Intention tremor (HP:0002080)1.67183920
159Nonprogressive disorder (HP:0003680)1.67142351
160Abnormal EKG (HP:0003115)1.65488658
161Gastroesophageal reflux (HP:0002020)1.65079629
162Esophageal atresia (HP:0002032)1.64864357
163Synostosis of carpal bones (HP:0005048)1.64662025
164Abnormal mitochondria in muscle tissue (HP:0008316)1.64660038
165Abnormality of the lower motor neuron (HP:0002366)1.64286576
166Hyperglycinuria (HP:0003108)1.63668111
167Hyperglycinemia (HP:0002154)1.63548110
168Hepatic necrosis (HP:0002605)1.63148781
169Urinary urgency (HP:0000012)1.63081999
170Termporal pattern (HP:0011008)1.62788361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.89146460
2NTRK34.84780637
3CASK4.70663446
4STK38L4.41960893
5EPHA44.41593786
6FRK3.29285812
7ZAK3.16008609
8MAP2K73.14740336
9LATS22.99081589
10TNIK2.81858131
11MAP3K42.76550794
12MAP3K92.54206850
13MAP3K122.51562997
14BMPR1B2.25478754
15DAPK22.24153636
16MINK12.18529633
17PRPF4B2.08306243
18RIPK42.04142960
19MARK11.96501063
20CDK191.93764992
21PLK21.80886593
22DAPK11.77735532
23MAP2K41.72855277
24ACVR1B1.62632669
25FGFR21.62037534
26NTRK21.61902388
27MAPK131.60879060
28ARAF1.51548455
29GRK51.51401188
30FES1.44606500
31KSR11.42506672
32CAMKK21.40468171
33AKT31.34529412
34CDK51.32749938
35PAK61.31629767
36MUSK1.31365959
37KSR21.31347476
38BMPR21.29875926
39PRKCG1.29761785
40CAMKK11.28064958
41STK31.28054483
42MAP4K21.26736768
43SGK21.25569542
44VRK21.25116764
45NUAK11.22282921
46GRK11.22276440
47PNCK1.20303224
48CAMK2A1.20052651
49SIK31.17564354
50MAP3K131.15080403
51CAMK2B1.11533438
52SGK4941.10988719
53SGK2231.10988719
54TAF11.08922030
55PRKD31.07845773
56NTRK11.07488320
57OXSR11.05770864
58PLK31.04455399
59CCNB11.02944903
60SIK20.99916078
61VRK10.99813622
62WEE10.95557303
63NLK0.95241705
64DYRK20.94716039
65NME10.94021131
66STK380.93708377
67CAMK10.93227301
68CSNK1A1L0.92987666
69PAK30.91365401
70PTK2B0.91085263
71PINK10.85593279
72MAP3K20.83711035
73TLK10.83550420
74TGFBR10.82093749
75EPHB20.81026342
76MKNK10.80623678
77BRAF0.78616654
78UHMK10.78391806
79PRKCE0.76303529
80WNK40.75194277
81SGK30.74726592
82TRIM280.72647918
83CSNK1G30.71233279
84SGK10.69846025
85CDC70.69245721
86CSNK1G10.68218721
87RAF10.67641881
88DYRK1A0.67321168
89STK390.67041824
90CDK180.66725336
91TNK20.66615452
92NEK60.66295898
93STK110.63835166
94ADRBK20.63818815
95STK160.63680708
96CAMK2D0.62405112
97FGR0.62391633
98INSRR0.62221200
99PHKG10.61154423
100PHKG20.61154423
101TAOK30.60844120
102PKN10.60780944
103CDK150.60379414
104CDK140.59716151
105CAMK2G0.58287527
106MAP3K10.56948237
107CDK30.56662189
108CSNK1G20.56375255
109MELK0.56261617
110MAP2K20.55760355
111MAPKAPK50.53083197
112CDK11A0.52864083
113MARK20.52364090
114BRSK20.51819470
115BCR0.51631856
116FER0.49103317
117GRK70.48389708
118PRKCH0.47054113
119PLK10.46962952
120MAP3K60.45425006
121PDK10.45074929
122TTK0.44267309
123MAPK150.44051989
124PASK0.42891853
125PDPK10.42331853
126PRKAA20.41641016
127PIK3CA0.41110507
128LMTK20.40956279
129CSNK1D0.40911951
130CAMK40.40051912
131CHEK20.39979639
132ADRBK10.39493865
133WNK30.39067396
134PRKACA0.37645516
135RPS6KA30.36683264
136TYRO30.34713511
137CDC42BPA0.34605746
138MAPK120.34572692
139ERBB20.34502176
140PRKG10.33345379
141PRKCA0.32835514
142BRSK10.32552460
143NEK10.31979434
144RET0.30998996
145MKNK20.30374749
146MAP2K10.29548652
147CSNK1A10.29527543
148FYN0.28979928
149PRKCZ0.28327106
150MAPK100.27409294

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.48326126
2Synaptic vesicle cycle_Homo sapiens_hsa047213.45664512
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.01089398
4Circadian entrainment_Homo sapiens_hsa047132.88407425
5Long-term potentiation_Homo sapiens_hsa047202.83469455
6Olfactory transduction_Homo sapiens_hsa047402.82925623
7Glutamatergic synapse_Homo sapiens_hsa047242.79576141
8GABAergic synapse_Homo sapiens_hsa047272.76504482
9Morphine addiction_Homo sapiens_hsa050322.75422618
10Amphetamine addiction_Homo sapiens_hsa050312.71063817
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30068680
12Salivary secretion_Homo sapiens_hsa049702.23604886
13Taste transduction_Homo sapiens_hsa047422.18918685
14Insulin secretion_Homo sapiens_hsa049112.17340367
15Dopaminergic synapse_Homo sapiens_hsa047282.16995489
16Collecting duct acid secretion_Homo sapiens_hsa049662.14996043
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13590821
18Serotonergic synapse_Homo sapiens_hsa047261.97395164
19Long-term depression_Homo sapiens_hsa047301.84747437
20Calcium signaling pathway_Homo sapiens_hsa040201.84710115
21Cholinergic synapse_Homo sapiens_hsa047251.83607912
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80730090
23Gastric acid secretion_Homo sapiens_hsa049711.77436979
24Renin secretion_Homo sapiens_hsa049241.76221288
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76036555
26Nitrogen metabolism_Homo sapiens_hsa009101.70708592
27Cocaine addiction_Homo sapiens_hsa050301.67260554
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61246935
29Oxytocin signaling pathway_Homo sapiens_hsa049211.56674178
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55466724
31Butanoate metabolism_Homo sapiens_hsa006501.53302733
32Protein export_Homo sapiens_hsa030601.50891388
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.50213111
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40523233
35cAMP signaling pathway_Homo sapiens_hsa040241.34170341
36GnRH signaling pathway_Homo sapiens_hsa049121.32805715
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29629012
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28159604
39Vibrio cholerae infection_Homo sapiens_hsa051101.23962581
40Homologous recombination_Homo sapiens_hsa034401.23129565
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22638406
42Basal cell carcinoma_Homo sapiens_hsa052171.21626345
43Tryptophan metabolism_Homo sapiens_hsa003801.21586024
44Propanoate metabolism_Homo sapiens_hsa006401.19792977
45Fanconi anemia pathway_Homo sapiens_hsa034601.16774246
46Basal transcription factors_Homo sapiens_hsa030221.16737679
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15745207
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15079896
49Gap junction_Homo sapiens_hsa045401.14826625
50Histidine metabolism_Homo sapiens_hsa003401.06885878
51Phototransduction_Homo sapiens_hsa047441.06115092
52Cardiac muscle contraction_Homo sapiens_hsa042601.03688049
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00615249
54Melanogenesis_Homo sapiens_hsa049160.99499378
55Axon guidance_Homo sapiens_hsa043600.98716906
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98150746
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97538957
58Linoleic acid metabolism_Homo sapiens_hsa005910.96799365
59Type II diabetes mellitus_Homo sapiens_hsa049300.96373646
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.96338362
61Oxidative phosphorylation_Homo sapiens_hsa001900.95358097
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94931242
63Hedgehog signaling pathway_Homo sapiens_hsa043400.94138756
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93275170
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92831504
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91251661
67Estrogen signaling pathway_Homo sapiens_hsa049150.88837392
68Pancreatic secretion_Homo sapiens_hsa049720.88036353
69Alzheimers disease_Homo sapiens_hsa050100.87327334
70beta-Alanine metabolism_Homo sapiens_hsa004100.87010290
71ErbB signaling pathway_Homo sapiens_hsa040120.86308360
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85998461
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85009927
74RNA polymerase_Homo sapiens_hsa030200.82228830
75Glioma_Homo sapiens_hsa052140.82226974
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80748212
77Circadian rhythm_Homo sapiens_hsa047100.77804219
78Type I diabetes mellitus_Homo sapiens_hsa049400.76675179
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76199362
80Sphingolipid metabolism_Homo sapiens_hsa006000.73247510
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70571179
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.67979182
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.67517703
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67383930
85Hippo signaling pathway_Homo sapiens_hsa043900.67377339
86Ribosome_Homo sapiens_hsa030100.67061081
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66725306
88MAPK signaling pathway_Homo sapiens_hsa040100.66418025
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.66362923
90One carbon pool by folate_Homo sapiens_hsa006700.66236091
91Thyroid hormone synthesis_Homo sapiens_hsa049180.64347194
92Ether lipid metabolism_Homo sapiens_hsa005650.63956997
93Oocyte meiosis_Homo sapiens_hsa041140.63561155
94ABC transporters_Homo sapiens_hsa020100.63080499
95Choline metabolism in cancer_Homo sapiens_hsa052310.63063018
96Dorso-ventral axis formation_Homo sapiens_hsa043200.62886995
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62807575
98Rheumatoid arthritis_Homo sapiens_hsa053230.60637408
99Ras signaling pathway_Homo sapiens_hsa040140.60288750
100Chemical carcinogenesis_Homo sapiens_hsa052040.59664034
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58474667
102Peroxisome_Homo sapiens_hsa041460.57708838
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56855821
104African trypanosomiasis_Homo sapiens_hsa051430.55725850
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54986596
106Dilated cardiomyopathy_Homo sapiens_hsa054140.54773105
107Folate biosynthesis_Homo sapiens_hsa007900.53524671
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53204999
109Parkinsons disease_Homo sapiens_hsa050120.52924729
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51621215
111Bile secretion_Homo sapiens_hsa049760.50177139
112Inositol phosphate metabolism_Homo sapiens_hsa005620.49975664
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49217114
114TGF-beta signaling pathway_Homo sapiens_hsa043500.48871405
115Selenocompound metabolism_Homo sapiens_hsa004500.48719333
116Rap1 signaling pathway_Homo sapiens_hsa040150.47727649
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.47579790
118Pyruvate metabolism_Homo sapiens_hsa006200.47115161
119RNA degradation_Homo sapiens_hsa030180.46879535
120Alcoholism_Homo sapiens_hsa050340.46637205
121Arginine and proline metabolism_Homo sapiens_hsa003300.46268412
122Glucagon signaling pathway_Homo sapiens_hsa049220.45655533
123Wnt signaling pathway_Homo sapiens_hsa043100.44617913
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43921802
125Retinol metabolism_Homo sapiens_hsa008300.43383455
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43066757
127Glycerolipid metabolism_Homo sapiens_hsa005610.42899243
128Huntingtons disease_Homo sapiens_hsa050160.42876281
129Proteasome_Homo sapiens_hsa030500.42341400
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42305879
131Metabolic pathways_Homo sapiens_hsa011000.42228805
132Purine metabolism_Homo sapiens_hsa002300.41317148
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.41222633
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40500262
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.37928926
136Ovarian steroidogenesis_Homo sapiens_hsa049130.35713789
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34165130
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33326675
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.29316591
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28270394
141VEGF signaling pathway_Homo sapiens_hsa043700.28232317
142Regulation of autophagy_Homo sapiens_hsa041400.26833720
143Chemokine signaling pathway_Homo sapiens_hsa040620.24083747
144Phagosome_Homo sapiens_hsa041450.22276801
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21991155
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21929974
147Endocytosis_Homo sapiens_hsa041440.21343131
148Melanoma_Homo sapiens_hsa052180.19455494
149Prion diseases_Homo sapiens_hsa050200.17741794
150Mineral absorption_Homo sapiens_hsa049780.17677100
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14410571
152Insulin signaling pathway_Homo sapiens_hsa049100.13955551

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