LGI4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)5.37469503
2sodium ion export (GO:0071436)5.30868441
3locomotory exploration behavior (GO:0035641)5.27382503
4alanine transport (GO:0032328)5.09176943
5central nervous system myelination (GO:0022010)4.86507272
6axon ensheathment in central nervous system (GO:0032291)4.86507272
7negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.83486417
8synaptic vesicle maturation (GO:0016188)4.72571037
9neuronal action potential propagation (GO:0019227)4.69653366
10L-amino acid import (GO:0043092)4.68029489
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.45935127
12positive regulation of synapse maturation (GO:0090129)4.45861686
13gamma-aminobutyric acid transport (GO:0015812)4.36860119
14C4-dicarboxylate transport (GO:0015740)4.32440441
15neurotransmitter-gated ion channel clustering (GO:0072578)4.21383514
16cell communication by electrical coupling (GO:0010644)4.16534337
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.12082636
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.11667873
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09748162
20positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.08935146
21potassium ion import (GO:0010107)4.08888541
22amino acid import (GO:0043090)4.04203806
23glutamate secretion (GO:0014047)3.96804229
24vocalization behavior (GO:0071625)3.95157003
25response to auditory stimulus (GO:0010996)3.89117011
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88743703
27regulation of synapse maturation (GO:0090128)3.82056195
28regulation of beta-amyloid formation (GO:1902003)3.80638228
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.79426778
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79281466
31proline transport (GO:0015824)3.78653504
32cellular sodium ion homeostasis (GO:0006883)3.77769101
33synaptic vesicle exocytosis (GO:0016079)3.76009857
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.69094095
35glycine transport (GO:0015816)3.67079563
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64789067
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.64473251
38layer formation in cerebral cortex (GO:0021819)3.63044849
39regulation of synapse structural plasticity (GO:0051823)3.62606875
40regulation of synaptic vesicle exocytosis (GO:2000300)3.60508358
41potassium ion homeostasis (GO:0055075)3.60190691
42glutamate receptor signaling pathway (GO:0007215)3.58472108
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.54530264
44neurotransmitter secretion (GO:0007269)3.52083135
45positive regulation of potassium ion transmembrane transport (GO:1901381)3.51569754
46regulation of glutamate receptor signaling pathway (GO:1900449)3.49059707
47regulation of neuronal synaptic plasticity (GO:0048168)3.48386795
48exploration behavior (GO:0035640)3.45311835
49regulation of amyloid precursor protein catabolic process (GO:1902991)3.44741891
50synaptic transmission, glutamatergic (GO:0035249)3.39490462
51postsynaptic membrane organization (GO:0001941)3.38694033
52positive regulation of cellular amide metabolic process (GO:0034250)3.37148836
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36999051
54auditory behavior (GO:0031223)3.34623211
55negative regulation of astrocyte differentiation (GO:0048712)3.32747369
56chondroitin sulfate catabolic process (GO:0030207)3.30295955
57cellular response to cholesterol (GO:0071397)3.26076612
58acidic amino acid transport (GO:0015800)3.26034067
59regulation of synaptic vesicle transport (GO:1902803)3.25555018
60L-serine transport (GO:0015825)3.24771365
61membrane repolarization (GO:0086009)3.22726811
62long-term memory (GO:0007616)3.21333266
63neuromuscular process controlling balance (GO:0050885)3.18609991
64regulation of neurotransmitter secretion (GO:0046928)3.17581723
65positive regulation of membrane potential (GO:0045838)3.13927516
66transmission of nerve impulse (GO:0019226)3.12981335
67dendrite morphogenesis (GO:0048813)3.12303216
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07799721
69dermatan sulfate biosynthetic process (GO:0030208)3.06969610
70L-glutamate transport (GO:0015813)3.06931710
71regulation of cell communication by electrical coupling (GO:0010649)3.05831128
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.05087549
73cerebellar granule cell differentiation (GO:0021707)3.00188245
74cytoskeletal anchoring at plasma membrane (GO:0007016)2.99790116
75cerebellar Purkinje cell differentiation (GO:0021702)2.99694723
76protein localization to synapse (GO:0035418)2.97942552
77long-term synaptic potentiation (GO:0060291)2.95871592
78regulation of dendritic spine development (GO:0060998)2.94271087
79neurotransmitter uptake (GO:0001504)2.94102749
80neuron-neuron synaptic transmission (GO:0007270)2.93899189
81dermatan sulfate metabolic process (GO:0030205)2.91158836
82neuromuscular process controlling posture (GO:0050884)2.90919841
83regulation of neurotransmitter transport (GO:0051588)2.89480053
84negative regulation of hormone metabolic process (GO:0032351)2.89428674
85negative regulation of hormone biosynthetic process (GO:0032353)2.89428674
86membrane depolarization during action potential (GO:0086010)2.89121820
87positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.88643639
88neurotransmitter transport (GO:0006836)2.88396869
89activation of protein kinase A activity (GO:0034199)2.88033062
90neuronal ion channel clustering (GO:0045161)2.87344790
91positive regulation of potassium ion transport (GO:0043268)2.86200686
92positive regulation of neurotransmitter transport (GO:0051590)2.85386499
93regulation of postsynaptic membrane potential (GO:0060078)2.84825122
94positive regulation of dendrite development (GO:1900006)2.83070941
95positive regulation of dendritic spine morphogenesis (GO:0061003)2.82028242
96regulation of synaptic plasticity (GO:0048167)2.80804952
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80651874
98regulation of voltage-gated calcium channel activity (GO:1901385)2.80534650
99neuron cell-cell adhesion (GO:0007158)2.78714922
100regulation of membrane repolarization (GO:0060306)2.77989980
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.77752981
102serine transport (GO:0032329)2.77273180
103dendritic spine morphogenesis (GO:0060997)2.77103441
104positive regulation of sodium ion transmembrane transport (GO:1902307)2.76882328
105prepulse inhibition (GO:0060134)2.76761316
106negative regulation of sodium ion transport (GO:0010766)2.76559879
107regulation of neurotransmitter levels (GO:0001505)2.75754871
108neuromuscular synaptic transmission (GO:0007274)2.74839205
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74809778
110cell communication involved in cardiac conduction (GO:0086065)2.74617186
111detection of calcium ion (GO:0005513)2.74519590
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.74391975
113cellular response to sterol (GO:0036315)2.73073677
114positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72554357
115dendritic spine organization (GO:0097061)2.72544193
116membrane depolarization (GO:0051899)2.69773845
117ovulation cycle (GO:0042698)2.67096714
118regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66631266
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.66453818
120positive regulation of dendritic spine development (GO:0060999)2.65547347
121regulation of ARF protein signal transduction (GO:0032012)2.63597897
122regulation of vesicle fusion (GO:0031338)2.62834594
123regulation of sodium ion transmembrane transport (GO:1902305)2.62663511
124regulation of dendritic spine morphogenesis (GO:0061001)2.62505861
125regulation of sodium ion transmembrane transporter activity (GO:2000649)2.62400268
126regulation of female receptivity (GO:0045924)2.62155600
127synaptic vesicle endocytosis (GO:0048488)2.61498084
128regulation of synaptic transmission (GO:0050804)2.60155301
129positive regulation of neurotransmitter secretion (GO:0001956)2.59957222
130cell migration in hindbrain (GO:0021535)2.56925536
131creatine metabolic process (GO:0006600)2.56523671
132cGMP-mediated signaling (GO:0019934)2.53896291
133negative regulation of dendrite morphogenesis (GO:0050774)2.53466833
134regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52763738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.36117246
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21316463
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96775224
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76289237
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76289237
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.73899176
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71715812
8* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60774026
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59946971
10* DROSHA_22980978_ChIP-Seq_HELA_Human2.56261801
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55308039
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52696694
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49114067
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44544086
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.43964592
16GBX2_23144817_ChIP-Seq_PC3_Human2.36265123
17REST_21632747_ChIP-Seq_MESCs_Mouse2.26398044
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20720021
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.20522778
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.17619914
21AR_21572438_ChIP-Seq_LNCaP_Human2.17608460
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.12733645
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12294824
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.10664854
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01625158
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.80643867
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.76815142
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74634585
29CTCF_27219007_Chip-Seq_Bcells_Human1.69486864
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60019371
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59334516
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55669042
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48586683
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44145064
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.43718601
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40735206
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38789100
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37812986
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36961691
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36876627
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35280786
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33040640
43KDM2B_26808549_Chip-Seq_K562_Human1.30935195
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30204308
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27816135
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26393718
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25965345
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.25658614
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24996023
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24147192
51SMAD4_21799915_ChIP-Seq_A2780_Human1.23898902
52AR_19668381_ChIP-Seq_PC3_Human1.23751641
53TP53_16413492_ChIP-PET_HCT116_Human1.22626973
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21174971
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.20398294
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20201910
57* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19220414
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19069117
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18018510
60SMC4_20622854_ChIP-Seq_HELA_Human1.17473397
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17120495
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16247571
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15778019
64RXR_22108803_ChIP-Seq_LS180_Human1.14316477
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.10622148
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10570629
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10471935
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09272424
69EGR1_19032775_ChIP-ChIP_M12_Human1.08886311
70P68_20966046_ChIP-Seq_HELA_Human1.08602982
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08142609
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08101872
73OCT4_19829295_ChIP-Seq_ESCs_Human1.07574545
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07216704
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07121214
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06503388
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.02028313
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01313315
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00612402
80KDM2B_26808549_Chip-Seq_DND41_Human1.00208132
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.00191501
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.00158874
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99501712
84GATA1_26923725_Chip-Seq_HPCs_Mouse0.98885632
85TET1_21490601_ChIP-Seq_MESCs_Mouse0.98211199
86* AR_25329375_ChIP-Seq_VCAP_Human0.97930611
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97008357
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96365155
89STAT3_23295773_ChIP-Seq_U87_Human0.96255510
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95449735
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95094213
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.95060721
93YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93975047
94* ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93958896
95CREB1_26743006_Chip-Seq_LNCaP_Human0.93956208
96ZNF274_21170338_ChIP-Seq_K562_Hela0.93616058
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92243582
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.92145416
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.91962599
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91840666
101AHR_22903824_ChIP-Seq_MCF-7_Human0.91369180
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91226804
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90564200
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.90454656
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89948381
106TRIM28_21343339_ChIP-Seq_HEK293_Human0.89472356
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.89318921
108KLF4_19829295_ChIP-Seq_ESCs_Human0.89279644
109SMAD3_21741376_ChIP-Seq_EPCs_Human0.89049888
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88525625
111CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88282991
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88043093
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87397488
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87119264
115* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87109427
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.87090899
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.86299725
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.86299725
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86264259
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85512334
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.85247486
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85042053
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84483699
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84460861
125P300_19829295_ChIP-Seq_ESCs_Human0.84138957
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83980574
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83965523
128TP53_18474530_ChIP-ChIP_U2OS_Human0.83761801
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83740394
130DPY_21335234_ChIP-Seq_ESCs_Mouse0.83678959
131SA1_27219007_Chip-Seq_Bcells_Human0.83225064
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.83032699
133LXR_22292898_ChIP-Seq_THP-1_Human0.80418400
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79701084
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.78990889
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.78691542
137MYC_27129775_Chip-Seq_CORNEA_Mouse0.75972226
138* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.75530230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.63064215
2MP0003635_abnormal_synaptic_transmissio3.56492215
3MP0004858_abnormal_nervous_system3.35354918
4MP0009046_muscle_twitch3.23239144
5MP0004270_analgesia3.13238779
6MP0003329_amyloid_beta_deposits3.04026313
7MP0001968_abnormal_touch/_nociception2.76742008
8MP0001486_abnormal_startle_reflex2.76548004
9MP0002064_seizures2.74716136
10MP0009745_abnormal_behavioral_response2.72291697
11MP0002063_abnormal_learning/memory/cond2.61820096
12MP0003880_abnormal_central_pattern2.55484768
13MP0005646_abnormal_pituitary_gland2.43513684
14MP0005423_abnormal_somatic_nervous2.41401039
15MP0002734_abnormal_mechanical_nocicepti2.40132174
16* MP0008569_lethality_at_weaning2.36455060
17MP0002272_abnormal_nervous_system2.34753550
18MP0002572_abnormal_emotion/affect_behav2.27266132
19* MP0003690_abnormal_glial_cell2.26486488
20MP0002736_abnormal_nociception_after2.22480349
21MP0009780_abnormal_chondrocyte_physiolo2.19927101
22MP0002733_abnormal_thermal_nociception2.16881914
23MP0004885_abnormal_endolymph2.07856892
24MP0001970_abnormal_pain_threshold1.88455899
25MP0002909_abnormal_adrenal_gland1.87656126
26MP0001440_abnormal_grooming_behavior1.87282953
27* MP0002067_abnormal_sensory_capabilities1.80033199
28MP0000751_myopathy1.79614453
29MP0003633_abnormal_nervous_system1.78722203
30MP0001501_abnormal_sleep_pattern1.77579880
31MP0002735_abnormal_chemical_nociception1.74987684
32MP0002822_catalepsy1.71452333
33MP0000604_amyloidosis1.64246165
34* MP0003634_abnormal_glial_cell1.63705132
35MP0003075_altered_response_to1.62832846
36MP0005167_abnormal_blood-brain_barrier1.57338410
37MP0001984_abnormal_olfaction1.56676901
38* MP0002557_abnormal_social/conspecific_i1.55909287
39MP0001502_abnormal_circadian_rhythm1.52164340
40* MP0003631_nervous_system_phenotype1.50872993
41MP0005670_abnormal_white_adipose1.50012995
42* MP0000920_abnormal_myelination1.44467320
43MP0000955_abnormal_spinal_cord1.41758871
44MP0002184_abnormal_innervation1.40399619
45MP0000778_abnormal_nervous_system1.37344451
46MP0002254_reproductive_system_inflammat1.35960036
47* MP0003632_abnormal_nervous_system1.35675747
48MP0004811_abnormal_neuron_physiology1.33228278
49MP0002653_abnormal_ependyma_morphology1.32250795
50MP0004924_abnormal_behavior1.29890863
51MP0005386_behavior/neurological_phenoty1.29890863
52* MP0002882_abnormal_neuron_morphology1.28206065
53MP0004145_abnormal_muscle_electrophysio1.27263530
54* MP0002066_abnormal_motor_capabilities/c1.25119759
55MP0001299_abnormal_eye_distance/1.24069340
56MP0003045_fibrosis1.23095156
57MP0005645_abnormal_hypothalamus_physiol1.22778932
58MP0003787_abnormal_imprinting1.21581395
59MP0003283_abnormal_digestive_organ1.18922067
60MP0003137_abnormal_impulse_conducting1.17055731
61MP0004142_abnormal_muscle_tone1.15813619
62MP0005171_absent_coat_pigmentation1.14410773
63MP0005623_abnormal_meninges_morphology1.12049176
64MP0003279_aneurysm1.07621712
65MP0003123_paternal_imprinting1.07241776
66MP0005377_hearing/vestibular/ear_phenot1.03812236
67MP0003878_abnormal_ear_physiology1.03812236
68MP0004036_abnormal_muscle_relaxation1.03316287
69MP0002152_abnormal_brain_morphology1.01501174
70MP0004215_abnormal_myocardial_fiber1.00715989
71MP0002090_abnormal_vision0.99940454
72MP0002638_abnormal_pupillary_reflex0.99611602
73MP0003183_abnormal_peptide_metabolism0.99048812
74MP0000749_muscle_degeneration0.98005764
75MP0001177_atelectasis0.93628858
76MP0002229_neurodegeneration0.89880266
77MP0005666_abnormal_adipose_tissue0.89036706
78MP0009840_abnormal_foam_cell0.86443739
79MP0002089_abnormal_postnatal_growth/wei0.86306073
80MP0004084_abnormal_cardiac_muscle0.85149039
81MP0004147_increased_porphyrin_level0.83593480
82MP0005551_abnormal_eye_electrophysiolog0.82907984
83MP0003122_maternal_imprinting0.79947166
84MP0004130_abnormal_muscle_cell0.79438866
85MP0004510_myositis0.78850033
86MP0001958_emphysema0.78682276
87MP0000013_abnormal_adipose_tissue0.78242413
88MP0001485_abnormal_pinna_reflex0.78186826
89MP0005375_adipose_tissue_phenotype0.75825864
90MP0001348_abnormal_lacrimal_gland0.75591849
91MP0004233_abnormal_muscle_weight0.75294525
92MP0004742_abnormal_vestibular_system0.74615035
93MP0008874_decreased_physiological_sensi0.74608798
94MP0000566_synostosis0.74246668
95MP0005620_abnormal_muscle_contractility0.73436058
96MP0003646_muscle_fatigue0.71840736
97MP0003172_abnormal_lysosome_physiology0.71295829
98MP0002971_abnormal_brown_adipose0.70350366
99MP0010329_abnormal_lipoprotein_level0.70330852
100MP0005409_darkened_coat_color0.70112509
101MP0002876_abnormal_thyroid_physiology0.69185323
102MP0003879_abnormal_hair_cell0.69005123
103MP0004087_abnormal_muscle_fiber0.67978317
104MP0000747_muscle_weakness0.67913652
105MP0002069_abnormal_eating/drinking_beha0.67656815
106MP0006138_congestive_heart_failure0.67535059
107MP0001963_abnormal_hearing_physiology0.66484487
108MP0004085_abnormal_heartbeat0.65502693
109MP0000003_abnormal_adipose_tissue0.65270445
110MP0005166_decreased_susceptibility_to0.65098152
111MP0005595_abnormal_vascular_smooth0.64688142
112MP0006276_abnormal_autonomic_nervous0.64460350
113MP0004043_abnormal_pH_regulation0.64425093
114MP0003136_yellow_coat_color0.64232457
115MP0005448_abnormal_energy_balance0.64027827
116MP0002972_abnormal_cardiac_muscle0.63229616
117* MP0002752_abnormal_somatic_nervous0.61260711
118MP0002295_abnormal_pulmonary_circulatio0.61201707
119MP0005253_abnormal_eye_physiology0.60822047
120MP0009384_cardiac_valve_regurgitation0.57373513
121MP0004272_abnormal_basement_membrane0.56067480
122MP0008872_abnormal_physiological_respon0.55931540
123MP0002108_abnormal_muscle_morphology0.55873525
124MP0001986_abnormal_taste_sensitivity0.55752326
125MP0005535_abnormal_body_temperature0.54740683
126MP0005165_increased_susceptibility_to0.54465842
127MP0001905_abnormal_dopamine_level0.54050422

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)6.41554853
2Megalencephaly (HP:0001355)5.85336303
3Myokymia (HP:0002411)5.62032240
4Focal motor seizures (HP:0011153)5.22241850
5Neurofibrillary tangles (HP:0002185)4.20664030
6Aplasia involving bones of the upper limbs (HP:0009823)4.14341887
7Aplasia of the phalanges of the hand (HP:0009802)4.14341887
8Aplasia involving bones of the extremities (HP:0009825)4.14341887
9Focal seizures (HP:0007359)4.06639659
10Obstructive sleep apnea (HP:0002870)3.69788092
11Supranuclear gaze palsy (HP:0000605)3.69310385
12Hemiplegia (HP:0002301)3.68438680
13Progressive cerebellar ataxia (HP:0002073)3.67001113
14Visual hallucinations (HP:0002367)3.52816500
15Epileptic encephalopathy (HP:0200134)3.41069004
16Nuclear cataract (HP:0100018)3.39423875
17Ulnar claw (HP:0001178)3.34192669
18Cerebral inclusion bodies (HP:0100314)3.30735396
19Hemiparesis (HP:0001269)3.28677623
20Diplopia (HP:0000651)3.23122097
21Abnormality of binocular vision (HP:0011514)3.23122097
22Dysdiadochokinesis (HP:0002075)3.21782742
23Intention tremor (HP:0002080)3.03359495
24Depression (HP:0000716)2.90369979
25Papilledema (HP:0001085)2.90105299
26Termporal pattern (HP:0011008)2.88993390
27Insidious onset (HP:0003587)2.88993390
28Atonic seizures (HP:0010819)2.88283487
29Febrile seizures (HP:0002373)2.82574945
30Hyporeflexia of lower limbs (HP:0002600)2.82348879
31Truncal ataxia (HP:0002078)2.81037404
32Generalized tonic-clonic seizures (HP:0002069)2.80687648
33Axonal loss (HP:0003447)2.75266034
34Postural instability (HP:0002172)2.70725937
35Muscle fiber splitting (HP:0003555)2.70714622
36Abnormal eating behavior (HP:0100738)2.66894032
37Dysmetria (HP:0001310)2.65106393
38Status epilepticus (HP:0002133)2.60847177
39Ankle clonus (HP:0011448)2.59486005
40Cerebral hypomyelination (HP:0006808)2.58628113
41Postural tremor (HP:0002174)2.57747524
42Segmental peripheral demyelination/remyelination (HP:0003481)2.57684544
43Peripheral hypomyelination (HP:0007182)2.56432438
44Akinesia (HP:0002304)2.47821514
45Absence seizures (HP:0002121)2.46417367
46Limb dystonia (HP:0002451)2.46248399
47Clumsiness (HP:0002312)2.44198152
48Insomnia (HP:0100785)2.43776988
49Foot dorsiflexor weakness (HP:0009027)2.43414525
50Increased CSF protein (HP:0002922)2.41794514
51Sleep apnea (HP:0010535)2.38405521
52Gaze-evoked nystagmus (HP:0000640)2.38360257
53Annular pancreas (HP:0001734)2.36780503
54Clonus (HP:0002169)2.35986170
55Lower limb amyotrophy (HP:0007210)2.35136620
56Dialeptic seizures (HP:0011146)2.33891013
57Bundle branch block (HP:0011710)2.33465263
58Abnormality of the foot musculature (HP:0001436)2.31569476
59Craniofacial dystonia (HP:0012179)2.31214567
60Anxiety (HP:0000739)2.29741191
61Onion bulb formation (HP:0003383)2.28596369
62Humeroradial synostosis (HP:0003041)2.28477735
63Synostosis involving the elbow (HP:0003938)2.28477735
64Delusions (HP:0000746)2.26564768
65Sudden death (HP:0001699)2.26039394
66Poor eye contact (HP:0000817)2.22402247
67Ventricular fibrillation (HP:0001663)2.17799374
68Hammertoe (HP:0001765)2.17469517
69Scanning speech (HP:0002168)2.17076419
70Impaired vibration sensation in the lower limbs (HP:0002166)2.16302097
71Abnormal social behavior (HP:0012433)2.15382014
72Impaired social interactions (HP:0000735)2.15382014
73Broad metatarsal (HP:0001783)2.13258966
74Exercise-induced myalgia (HP:0003738)2.09842196
75Rapidly progressive (HP:0003678)2.08600292
76Difficulty running (HP:0009046)2.08561010
77Atrioventricular block (HP:0001678)2.07613643
78Impaired smooth pursuit (HP:0007772)2.07262495
79Broad-based gait (HP:0002136)2.06417968
80Torticollis (HP:0000473)2.04500284
81Abnormality of the periventricular white matter (HP:0002518)2.00046995
82Tetraplegia (HP:0002445)1.97549681
83Abnormality of ocular smooth pursuit (HP:0000617)1.97261201
84Syncope (HP:0001279)1.95199977
85Urinary bladder sphincter dysfunction (HP:0002839)1.94600319
86EMG: neuropathic changes (HP:0003445)1.94032908
87Bronchomalacia (HP:0002780)1.93824525
88Alacrima (HP:0000522)1.93258685
89Polygenic inheritance (HP:0010982)1.92991978
90Rigidity (HP:0002063)1.92567445
91Apathy (HP:0000741)1.92064792
92Gait ataxia (HP:0002066)1.91930947
93Spinal canal stenosis (HP:0003416)1.91622782
94Stereotypic behavior (HP:0000733)1.90930377
95Turricephaly (HP:0000262)1.90038709
96Dysmetric saccades (HP:0000641)1.89136648
97Polar cataract (HP:0010696)1.88719904
98Lower limb muscle weakness (HP:0007340)1.88094224
99Prolonged QT interval (HP:0001657)1.88058422
100Bradykinesia (HP:0002067)1.87666448
101Pointed chin (HP:0000307)1.86343788
102Ventricular arrhythmia (HP:0004308)1.86036269
103Neuronal loss in central nervous system (HP:0002529)1.84962211
104Narrow nasal bridge (HP:0000446)1.84901303
105Focal dystonia (HP:0004373)1.82997064
106Urinary urgency (HP:0000012)1.82829742
107Incomplete penetrance (HP:0003829)1.82749065
108Dementia (HP:0000726)1.81470291
109Slow progression (HP:0003677)1.81351451
110Hypsarrhythmia (HP:0002521)1.80211229
111Polyphagia (HP:0002591)1.80023977
112Impaired proprioception (HP:0010831)1.79972893
113EEG with generalized epileptiform discharges (HP:0011198)1.79961513
114Myotonia (HP:0002486)1.79528261
115Back pain (HP:0003418)1.78003259
116EMG: myopathic abnormalities (HP:0003458)1.77356446
117Abnormality of saccadic eye movements (HP:0000570)1.76396204
118Abnormality of the lower motor neuron (HP:0002366)1.75958304
119Epileptiform EEG discharges (HP:0011182)1.75921366
120Type 1 muscle fiber predominance (HP:0003803)1.75890970
121Muscle stiffness (HP:0003552)1.75873658
122Split foot (HP:0001839)1.75669608
123Spastic gait (HP:0002064)1.75253793
124Genetic anticipation (HP:0003743)1.73715834
125Heart block (HP:0012722)1.73603591
126Abnormal EKG (HP:0003115)1.73063111
127Mesangial abnormality (HP:0001966)1.72862222
128Mutism (HP:0002300)1.64767035
129Limb ataxia (HP:0002070)1.62623845
130Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.62049014
131Steppage gait (HP:0003376)1.61230586
132Psychosis (HP:0000709)1.60744864
133Abnormal atrioventricular conduction (HP:0005150)1.60264331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.73084199
2LMTK24.63544325
3PRKD33.85064091
4NTRK33.25339173
5PHKG13.07902713
6PHKG23.07902713
7NTRK22.74360174
8MAP3K92.43932369
9MINK12.09075105
10PAK61.92832912
11KSR21.84209792
12CAMKK11.83257235
13MAP3K41.81875028
14TNIK1.71497624
15NTRK11.67291738
16TYRO31.62325738
17RIPK11.60498866
18STK381.59984600
19MAP2K61.56967069
20DAPK21.56422014
21PINK11.53325784
22SGK2231.43539989
23SGK4941.43539989
24TRIB31.42528948
25CAMKK21.32003273
26CDK51.30052090
27MAP3K131.28918235
28MARK11.27876556
29PRKCH1.26290811
30WNK11.24709491
31FGFR21.21360609
32MAP2K71.20813242
33PRPF4B1.18574660
34SGK21.16821015
35SGK31.15684561
36PKN11.14597319
37RIPK41.13824007
38MAPK131.12342735
39SIK11.11221101
40MAP2K41.07953189
41PRKCG1.07309231
42RET1.05086381
43MAP3K20.96219597
44OBSCN0.95496052
45DDR20.93106393
46PDGFRA0.90985166
47CASK0.89892514
48CAMK1G0.88811474
49SIK20.87082036
50CDC42BPA0.84501664
51ROCK20.82071323
52DMPK0.81948856
53CAMK10.80755555
54BMX0.78989873
55MUSK0.77255788
56MAP3K110.75572932
57ROCK10.75469819
58CDK190.74585210
59DAPK30.74406664
60GRK50.73789555
61KSR10.72943724
62CAMK2A0.72405800
63PAK30.72394142
64UHMK10.71818445
65SGK10.68566389
66FES0.68315571
67MAPK40.68224389
68CDK150.65741362
69TNK20.64794196
70CAMK2G0.64103118
71CAMK1D0.62877259
72CDK180.62589048
73STK110.62334867
74LATS20.61592333
75CAMK40.60970390
76MAP3K70.60893905
77MARK20.58614815
78CAMK2B0.56566051
79CDK140.56455396
80ALK0.56140825
81CDK11A0.55828201
82CAMK2D0.55554730
83PIK3CG0.54868264
84PDPK10.54121973
85MAPK120.53364891
86PDK10.53276051
87RPS6KA30.53112714
88NEK60.52618234
89DYRK1A0.52553391
90PTK2B0.48597463
91BRAF0.48534635
92MAP3K10.47698559
93TTN0.47016256
94FGR0.46978264
95PRKG20.46612736
96ARAF0.46415820
97PRKCZ0.45797179
98FYN0.44844424
99PRKCE0.44461706
100PLK20.44373293
101TESK10.44200357
102PRKD10.43611535
103PRKD20.43364431
104ADRBK10.43135077
105MAPK70.42920603
106MAPK100.41544907
107MAP2K10.41238870
108DAPK10.40974510
109PRKG10.40507648
110BRSK10.40491613
111SCYL20.40293054
112LIMK10.39515323
113IRAK20.38977367
114ERBB20.38801393
115EPHB10.38665495
116PDK30.38449429
117PDK40.38449429
118SRC0.37633368
119TAOK10.37361407
120PRKAA10.36442051
121PRKACA0.35079751

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.91923810
2Nicotine addiction_Homo sapiens_hsa050332.76143348
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.65508593
4Fatty acid biosynthesis_Homo sapiens_hsa000612.55922463
5Glutamatergic synapse_Homo sapiens_hsa047242.39712324
6GABAergic synapse_Homo sapiens_hsa047272.22330956
7Circadian entrainment_Homo sapiens_hsa047132.22163897
8Olfactory transduction_Homo sapiens_hsa047402.16258584
9Synaptic vesicle cycle_Homo sapiens_hsa047212.16133197
10Salivary secretion_Homo sapiens_hsa049702.11153916
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04748380
12Long-term potentiation_Homo sapiens_hsa047202.01926647
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95574184
14Gastric acid secretion_Homo sapiens_hsa049711.93340142
15Insulin secretion_Homo sapiens_hsa049111.93278163
16Morphine addiction_Homo sapiens_hsa050321.92097621
17Amphetamine addiction_Homo sapiens_hsa050311.66465534
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59951336
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55895249
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49305020
21Histidine metabolism_Homo sapiens_hsa003401.46894790
22Cholinergic synapse_Homo sapiens_hsa047251.46315075
23Taste transduction_Homo sapiens_hsa047421.44503482
24Dopaminergic synapse_Homo sapiens_hsa047281.42923669
25Calcium signaling pathway_Homo sapiens_hsa040201.41828025
26Cocaine addiction_Homo sapiens_hsa050301.41130480
27Long-term depression_Homo sapiens_hsa047301.37687276
28Arginine and proline metabolism_Homo sapiens_hsa003301.36442383
29Renin secretion_Homo sapiens_hsa049241.27432346
30Oxytocin signaling pathway_Homo sapiens_hsa049211.18587727
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17570556
32GnRH signaling pathway_Homo sapiens_hsa049121.16841132
33cAMP signaling pathway_Homo sapiens_hsa040241.16310135
34Fatty acid metabolism_Homo sapiens_hsa012121.14188324
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11750136
36Gap junction_Homo sapiens_hsa045401.11566339
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.11255636
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07499542
39Vitamin B6 metabolism_Homo sapiens_hsa007501.07233024
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02730346
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.01222505
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01143176
43Bile secretion_Homo sapiens_hsa049761.00749285
44Pancreatic secretion_Homo sapiens_hsa049720.99482333
45Dilated cardiomyopathy_Homo sapiens_hsa054140.98829632
46Type II diabetes mellitus_Homo sapiens_hsa049300.98602209
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97462841
48Dorso-ventral axis formation_Homo sapiens_hsa043200.97020821
49Estrogen signaling pathway_Homo sapiens_hsa049150.96907021
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96365977
51Serotonergic synapse_Homo sapiens_hsa047260.95077123
52Melanogenesis_Homo sapiens_hsa049160.94263985
53Glioma_Homo sapiens_hsa052140.93157036
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91540794
55Thyroid hormone synthesis_Homo sapiens_hsa049180.91211245
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88997892
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88539601
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83308214
59Fatty acid degradation_Homo sapiens_hsa000710.82745407
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77580346
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77574175
62Phenylalanine metabolism_Homo sapiens_hsa003600.75981812
63Axon guidance_Homo sapiens_hsa043600.75859650
64Circadian rhythm_Homo sapiens_hsa047100.75074354
65beta-Alanine metabolism_Homo sapiens_hsa004100.74484317
66ErbB signaling pathway_Homo sapiens_hsa040120.74062059
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73309270
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73080583
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72148363
70Cardiac muscle contraction_Homo sapiens_hsa042600.70883085
71Collecting duct acid secretion_Homo sapiens_hsa049660.70802925
72Glucagon signaling pathway_Homo sapiens_hsa049220.69561371
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.67179295
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66356783
75PPAR signaling pathway_Homo sapiens_hsa033200.63360387
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62637379
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62253123
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.60830856
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.60223179
80Ovarian steroidogenesis_Homo sapiens_hsa049130.59139728
81Rap1 signaling pathway_Homo sapiens_hsa040150.59012017
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57898759
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.56916131
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56065863
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54613848
86Choline metabolism in cancer_Homo sapiens_hsa052310.53984086
87Mineral absorption_Homo sapiens_hsa049780.53735765
88Inositol phosphate metabolism_Homo sapiens_hsa005620.53043882
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50752079
90Insulin signaling pathway_Homo sapiens_hsa049100.50317083
91AMPK signaling pathway_Homo sapiens_hsa041520.49486215
92Arginine biosynthesis_Homo sapiens_hsa002200.48839341
93MAPK signaling pathway_Homo sapiens_hsa040100.47092749
94Butanoate metabolism_Homo sapiens_hsa006500.43432774
95African trypanosomiasis_Homo sapiens_hsa051430.42392450
96Endocytosis_Homo sapiens_hsa041440.40813161
97Prion diseases_Homo sapiens_hsa050200.40541777
98Ras signaling pathway_Homo sapiens_hsa040140.39660043
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.38258458
100VEGF signaling pathway_Homo sapiens_hsa043700.37120418
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37021710
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36469320
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35198870
104Proteoglycans in cancer_Homo sapiens_hsa052050.34553161
105Tight junction_Homo sapiens_hsa045300.33479237
106Fructose and mannose metabolism_Homo sapiens_hsa000510.33390819
107Insulin resistance_Homo sapiens_hsa049310.33311562
108Vibrio cholerae infection_Homo sapiens_hsa051100.33286885
109Glycerolipid metabolism_Homo sapiens_hsa005610.30998680
110Alzheimers disease_Homo sapiens_hsa050100.30899029
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30731615
112Propanoate metabolism_Homo sapiens_hsa006400.29779783
113Hedgehog signaling pathway_Homo sapiens_hsa043400.29537249
114Wnt signaling pathway_Homo sapiens_hsa043100.29522592
115Focal adhesion_Homo sapiens_hsa045100.29161735
116Phototransduction_Homo sapiens_hsa047440.28749268
117Endometrial cancer_Homo sapiens_hsa052130.28181865
118Oocyte meiosis_Homo sapiens_hsa041140.27992810
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.27970878
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27915293
121Protein digestion and absorption_Homo sapiens_hsa049740.27412779

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