LGMN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.10104490
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.10104490
3positive regulation by organism of defense response of other organism involved in symbiotic interact7.10104490
4modulation by symbiont of host immune response (GO:0052553)7.10104490
5positive regulation by symbiont of host defense response (GO:0052509)7.10104490
6modulation by symbiont of host defense response (GO:0052031)7.10104490
7microglial cell activation (GO:0001774)6.90718713
8regulation of interferon-beta biosynthetic process (GO:0045357)6.86674210
9macrophage activation involved in immune response (GO:0002281)6.25911460
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.81930289
11negative regulation of interleukin-12 production (GO:0032695)5.41308722
12positive regulation of chemokine secretion (GO:0090197)5.12724777
13amino sugar catabolic process (GO:0046348)4.88730249
14positive regulation of interferon-alpha production (GO:0032727)4.83951137
15macrophage activation (GO:0042116)4.65622936
16regulation of interferon-alpha production (GO:0032647)4.60463123
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.53735464
18response to host immune response (GO:0052572)4.53735464
19keratan sulfate catabolic process (GO:0042340)4.52369931
20G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.49272119
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.39957500
22N-acetylneuraminate metabolic process (GO:0006054)4.32814214
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.26570550
24response to host (GO:0075136)4.26570550
25response to host defenses (GO:0052200)4.26570550
26positive regulation of chemokine biosynthetic process (GO:0045080)4.09589342
27virion attachment to host cell (GO:0019062)4.08202900
28T-helper 1 type immune response (GO:0042088)4.05592416
29membrane lipid catabolic process (GO:0046466)4.00758098
30glycosphingolipid catabolic process (GO:0046479)3.97351200
31negative regulation of nitric oxide biosynthetic process (GO:0045019)3.96800652
32regulation of vitamin D biosynthetic process (GO:0060556)3.95546353
33regulation of cytokine secretion involved in immune response (GO:0002739)3.95113164
34neutrophil activation involved in immune response (GO:0002283)3.93792376
35regulation of B cell receptor signaling pathway (GO:0050855)3.91789366
36negative regulation of granulocyte differentiation (GO:0030853)3.88381178
37positive regulation of antigen processing and presentation (GO:0002579)3.86999527
38sphingolipid catabolic process (GO:0030149)3.84374024
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.77715140
40regulation of chemokine secretion (GO:0090196)3.77695367
41hyaluronan catabolic process (GO:0030214)3.66918225
42regulation of podosome assembly (GO:0071801)3.63666147
43adhesion of symbiont to host (GO:0044406)3.61772058
44oligosaccharide catabolic process (GO:0009313)3.60530227
45mannose metabolic process (GO:0006013)3.57972095
46positive regulation of heat generation (GO:0031652)3.53747898
47I-kappaB phosphorylation (GO:0007252)3.53441960
48myeloid cell activation involved in immune response (GO:0002275)3.50471799
49myeloid dendritic cell differentiation (GO:0043011)3.50065366
50positive regulation of monocyte chemotaxis (GO:0090026)3.49182117
51glycolipid catabolic process (GO:0019377)3.48897726
52immunoglobulin mediated immune response (GO:0016064)3.48461843
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.47632329
54low-density lipoprotein particle clearance (GO:0034383)3.45016882
55monocyte chemotaxis (GO:0002548)3.44283582
56regulation of chemokine biosynthetic process (GO:0045073)3.42258929
57barbed-end actin filament capping (GO:0051016)3.41744534
58positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.41027273
59cellular response to thyroid hormone stimulus (GO:0097067)3.39969925
60pinocytosis (GO:0006907)3.36559485
61respiratory burst (GO:0045730)3.34717758
62purinergic nucleotide receptor signaling pathway (GO:0035590)3.32287936
63NIK/NF-kappaB signaling (GO:0038061)3.31555190
64regulation of fever generation (GO:0031620)3.30476519
65cellular response to arsenic-containing substance (GO:0071243)3.28552873
66positive regulation of cellular amide metabolic process (GO:0034250)3.28189297
67response to thyroid hormone (GO:0097066)3.28160428
68regulation of membrane protein ectodomain proteolysis (GO:0051043)3.27408769
69negative regulation of cytokine production involved in immune response (GO:0002719)3.25983594
70apoptotic cell clearance (GO:0043277)3.25802550
71response to peptidoglycan (GO:0032494)3.24519876
72interferon-gamma-mediated signaling pathway (GO:0060333)3.19471258
73regulation of vitamin metabolic process (GO:0030656)3.17952655
74G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.16915252
75positive regulation of mast cell activation involved in immune response (GO:0033008)3.16463962
76positive regulation of mast cell degranulation (GO:0043306)3.16463962
77positive regulation of interferon-beta production (GO:0032728)3.15638957
78regulation of macrophage chemotaxis (GO:0010758)3.14187766
79regulation of mononuclear cell migration (GO:0071675)3.12843722
80branching involved in labyrinthine layer morphogenesis (GO:0060670)3.12472165
81regulation of antigen processing and presentation (GO:0002577)3.09801163
82negative regulation of myeloid cell apoptotic process (GO:0033033)3.07578583
83myeloid dendritic cell activation (GO:0001773)3.05373455
84ceramide catabolic process (GO:0046514)3.04444955
85fat-soluble vitamin biosynthetic process (GO:0042362)3.03459303
86negative regulation of interleukin-6 production (GO:0032715)3.02504976
87negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.94644404
88regulation of T-helper 1 cell differentiation (GO:0045625)2.93859498
89regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.91451693
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89142004
91regulation of chronic inflammatory response (GO:0002676)2.87357360
92cellular response to lipopolysaccharide (GO:0071222)2.86363205
93adenosine receptor signaling pathway (GO:0001973)2.85965708
94positive regulation of cholesterol efflux (GO:0010875)2.83655814
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83552322
96regulation of cholesterol storage (GO:0010885)2.82730798
97negative regulation of mast cell activation (GO:0033004)2.80589597
98regulation of interleukin-12 production (GO:0032655)2.79345994
99regulation of interleukin-8 biosynthetic process (GO:0045414)2.77857517
100cellular response to molecule of bacterial origin (GO:0071219)2.75829186
101B cell mediated immunity (GO:0019724)2.75173190
102regulation of inflammatory response to antigenic stimulus (GO:0002861)2.74945485
103positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.74577505
104purinergic receptor signaling pathway (GO:0035587)2.73949395
105plasma lipoprotein particle clearance (GO:0034381)2.71694128
106regulation of superoxide anion generation (GO:0032928)2.71550029
107regulation of chemokine-mediated signaling pathway (GO:0070099)2.70119310
108hydrogen peroxide biosynthetic process (GO:0050665)2.68738805
109myeloid leukocyte activation (GO:0002274)2.68586008
110positive regulation of interleukin-6 production (GO:0032755)2.67984083
111regulation of nitric oxide biosynthetic process (GO:0045428)2.67783747
112type I interferon signaling pathway (GO:0060337)2.67678204
113cellular response to type I interferon (GO:0071357)2.67678204
114protein localization to endosome (GO:0036010)2.67502361
115toxin transport (GO:1901998)2.66753836
116regulation of heat generation (GO:0031650)2.66724682
117granulocyte activation (GO:0036230)2.66558499
118phagosome maturation (GO:0090382)2.66061043
119negative regulation of interleukin-17 production (GO:0032700)2.65738260
120response to lipoprotein particle (GO:0055094)2.65117872
121positive regulation of chemokine production (GO:0032722)2.65012721
122positive regulation of B cell differentiation (GO:0045579)2.63924262
123lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63718810
124ruffle organization (GO:0031529)2.63072970
125chondroitin sulfate catabolic process (GO:0030207)2.62804615
126regulation of mast cell degranulation (GO:0043304)2.62324672
127regulation of interferon-gamma biosynthetic process (GO:0045072)2.62200159
128regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61291179
129detection of molecule of bacterial origin (GO:0032490)2.59357633
130phagocytosis, engulfment (GO:0006911)2.57859932
131cellular extravasation (GO:0045123)2.57230185
132response to laminar fluid shear stress (GO:0034616)2.57067968
133positive regulation of macrophage cytokine production (GO:0060907)2.55743962
134regulation of mast cell activation involved in immune response (GO:0033006)2.54981999
135neutrophil activation (GO:0042119)2.54942300
136response to muramyl dipeptide (GO:0032495)2.53133981
137cytidine deamination (GO:0009972)2.52241023
138cytidine metabolic process (GO:0046087)2.52241023
139cytidine catabolic process (GO:0006216)2.52241023
140positive regulation of toll-like receptor signaling pathway (GO:0034123)2.50580366
141lysosome organization (GO:0007040)2.49274106
142lytic vacuole organization (GO:0080171)2.49274106
143positive regulation of leukocyte degranulation (GO:0043302)2.47184024
144positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.42304046
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.41263546
146negative regulation of bone resorption (GO:0045779)2.39389084
147basic amino acid transport (GO:0015802)2.39291849
148regulation of leukocyte degranulation (GO:0043300)2.39203143
149regulation of monocyte chemotaxis (GO:0090025)2.37030487
150regulation of mast cell activation (GO:0033003)2.36915899
151negative regulation of B cell proliferation (GO:0030889)2.35859628
152cell adhesion mediated by integrin (GO:0033627)2.32362810
153positive regulation of mast cell activation (GO:0033005)2.32300763
154negative regulation of tissue remodeling (GO:0034104)2.31384062
155dendritic cell differentiation (GO:0097028)2.31119340
156adhesion of symbiont to host cell (GO:0044650)2.30083496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.89522424
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.06153878
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.47805262
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.38051734
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.01271887
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.39251995
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26497458
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.26362197
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47888876
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46980322
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23508540
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19020929
13SPI1_23127762_ChIP-Seq_K562_Human2.14289558
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05539222
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00361022
16PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.99925382
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92160769
18BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87766061
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87432049
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87084453
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.81144321
22* VDR_24787735_ChIP-Seq_THP-1_Human1.80676288
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77518233
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.77113256
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74835919
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.71058983
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67600721
28* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67206271
29NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.61770171
30TFEB_21752829_ChIP-Seq_HELA_Human1.58966072
31RUNX_20019798_ChIP-Seq_JUKART_Human1.57809321
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57479349
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52052227
34PU_27001747_Chip-Seq_BMDM_Mouse1.51310482
35SPI1_23547873_ChIP-Seq_NB4_Human1.49907558
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.49876648
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49434030
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48414930
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48085551
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46517542
41SCL_19346495_ChIP-Seq_HPC-7_Human1.45400069
42* VDR_24763502_ChIP-Seq_THP-1_Human1.43289111
43CLOCK_20551151_ChIP-Seq_293T_Human1.42599530
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37820519
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36548620
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.32527030
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.31851031
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30946203
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30806221
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29994081
51LXR_22292898_ChIP-Seq_THP-1_Human1.28263560
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.26699199
53STAT1_20625510_ChIP-Seq_HELA_Human1.26447028
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26409815
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26237968
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.23610007
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22205021
58VDR_21846776_ChIP-Seq_THP-1_Human1.21368593
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21229573
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19972583
61GATA1_19941826_ChIP-Seq_K562_Human1.19618453
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.19193048
63GATA1_22025678_ChIP-Seq_K562_Human1.19185088
64EGR1_19032775_ChIP-ChIP_M12_Human1.18279612
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.17924180
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16340980
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16160695
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15528963
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15222490
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14751521
71GATA2_19941826_ChIP-Seq_K562_Human1.09395211
72MAF_26560356_Chip-Seq_TH1_Human1.08648876
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08490584
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06672330
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06073660
76BCL6_27268052_Chip-Seq_Bcells_Human1.05311628
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04709878
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03663696
79BCOR_27268052_Chip-Seq_Bcells_Human1.03329779
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03041890
81SOX2_20726797_ChIP-Seq_SW620_Human1.02942913
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.02645132
83CJUN_26792858_Chip-Seq_BT549_Human1.02611198
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02045033
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01703169
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00854579
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00792124
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97727322
89TCF7_22412390_ChIP-Seq_EML_Mouse0.97691724
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97183937
91* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96816984
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94905845
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94675407
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94229361
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94054949
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93916685
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93496331
98KDM2B_26808549_Chip-Seq_DND41_Human0.93132398
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93055040
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93008071
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92806861
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.92256220
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91870013
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91511946
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90890835
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90890835
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90890348
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90719975
109GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90604900
110GATA3_26560356_Chip-Seq_TH2_Human0.89642209
111MYB_26560356_Chip-Seq_TH2_Human0.89447611
112FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87769275
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87324580
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.86408517
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86087956
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.85816054
117SPI1_20517297_ChIP-Seq_HL60_Human0.85635533
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85524402
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83373525
120RACK7_27058665_Chip-Seq_MCF-7_Human0.83136262
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81727560
122* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81687533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005058_abnormal_lysosome_morphology5.40700464
2MP0003191_abnormal_cellular_cholesterol4.43167594
3MP0003172_abnormal_lysosome_physiology4.03474122
4MP0006082_CNS_inflammation3.99722261
5MP0009840_abnormal_foam_cell3.56408659
6MP0002139_abnormal_hepatobiliary_system3.48871088
7MP0001835_abnormal_antigen_presentation3.35701342
8MP0003303_peritoneal_inflammation2.90785736
9MP0003690_abnormal_glial_cell2.80638839
10MP0003436_decreased_susceptibility_to2.51093427
11* MP0002419_abnormal_innate_immunity2.49477590
12MP0003075_altered_response_to2.16989755
13MP0005464_abnormal_platelet_physiology2.15844941
14MP0000604_amyloidosis2.13227447
15MP0002148_abnormal_hypersensitivity_rea2.13179035
16MP0003300_gastrointestinal_ulcer2.10487461
17MP0008438_abnormal_cutaneous_collagen2.10006682
18MP0005000_abnormal_immune_tolerance2.03385814
19MP0001533_abnormal_skeleton_physiology2.02694731
20MP0000343_altered_response_to1.99006685
21MP0004510_myositis1.89313391
22MP0005671_abnormal_response_to1.88170251
23MP0003724_increased_susceptibility_to1.83245501
24* MP0002452_abnormal_antigen_presenting1.82274025
25MP0005451_abnormal_body_composition1.76258761
26MP0002998_abnormal_bone_remodeling1.73870969
27MP0006054_spinal_hemorrhage1.69080146
28MP0001790_abnormal_immune_system1.65920071
29MP0005387_immune_system_phenotype1.65920071
30MP0005025_abnormal_response_to1.64138125
31MP0003806_abnormal_nucleotide_metabolis1.62932304
32MP0005166_decreased_susceptibility_to1.60848828
33MP0005167_abnormal_blood-brain_barrier1.58278906
34MP0003183_abnormal_peptide_metabolism1.57574889
35* MP0002723_abnormal_immune_serum1.54250190
36MP0001958_emphysema1.51366229
37MP0001800_abnormal_humoral_immune1.49605115
38MP0003453_abnormal_keratinocyte_physiol1.49350886
39MP0003566_abnormal_cell_adhesion1.47108361
40MP0009785_altered_susceptibility_to1.45343802
41* MP0008469_abnormal_protein_level1.42521798
42MP0004019_abnormal_vitamin_homeostasis1.38673753
43MP0005310_abnormal_salivary_gland1.38602316
44MP0001845_abnormal_inflammatory_respons1.36998660
45MP0005397_hematopoietic_system_phenotyp1.36847970
46MP0001545_abnormal_hematopoietic_system1.36847970
47* MP0001819_abnormal_immune_cell1.34922348
48* MP0002420_abnormal_adaptive_immunity1.31472027
49MP0002090_abnormal_vision1.29356937
50MP0003329_amyloid_beta_deposits1.28654175
51MP0002136_abnormal_kidney_physiology1.27955158
52MP0005365_abnormal_bile_salt1.26694190
53MP0003279_aneurysm1.25679684
54MP0005670_abnormal_white_adipose1.25336943
55MP0005257_abnormal_intraocular_pressure1.23464418
56MP0000465_gastrointestinal_hemorrhage1.22032899
57MP0000685_abnormal_immune_system1.20989264
58MP0009643_abnormal_urine_homeostasis1.20432546
59MP0004883_abnormal_blood_vessel1.19117751
60MP0001542_abnormal_bone_strength1.18729743
61MP0001756_abnormal_urination1.17683301
62MP0000920_abnormal_myelination1.15493640
63MP0008004_abnormal_stomach_pH1.14951626
64MP0004858_abnormal_nervous_system1.13739079
65MP0002405_respiratory_system_inflammati1.12324155
66MP0001851_eye_inflammation1.12241131
67MP0003448_altered_tumor_morphology1.10180301
68MP0003195_calcinosis1.09670176
69MP0003634_abnormal_glial_cell1.09404374
70MP0003705_abnormal_hypodermis_morpholog1.09164555
71MP0002837_dystrophic_cardiac_calcinosis1.05099442
72MP0005165_increased_susceptibility_to1.04634962
73MP0002933_joint_inflammation1.04359931
74MP0009278_abnormal_bone_marrow1.04031477
75MP0001915_intracranial_hemorrhage1.03913778
76MP0009764_decreased_sensitivity_to1.03836695
77MP0004947_skin_inflammation1.03636282
78MP0002254_reproductive_system_inflammat1.01801446
79MP0005164_abnormal_response_to0.99983887
80MP0000249_abnormal_blood_vessel0.99644892
81MP0003045_fibrosis0.97049297
82MP0005360_urolithiasis0.94587304
83MP0002138_abnormal_hepatobiliary_system0.94414501
84MP0009333_abnormal_splenocyte_physiolog0.93021445
85MP0005390_skeleton_phenotype0.92667962
86MP0003252_abnormal_bile_duct0.92560016
87MP0005332_abnormal_amino_acid0.92407080
88MP0003186_abnormal_redox_activity0.91632285
89* MP0000689_abnormal_spleen_morphology0.91150337
90MP0000767_abnormal_smooth_muscle0.88469062
91MP0002332_abnormal_exercise_endurance0.86867741
92MP0001853_heart_inflammation0.86831303
93* MP0000716_abnormal_immune_system0.85777467
94MP0003795_abnormal_bone_structure0.84917004
95MP0008260_abnormal_autophagy0.84109739
96MP0009763_increased_sensitivity_to0.83695962
97MP0003091_abnormal_cell_migration0.82797649
98MP0005023_abnormal_wound_healing0.82555955
99MP0005584_abnormal_enzyme/coenzyme_acti0.80244846
100MP0000569_abnormal_digit_pigmentation0.79583053
101MP0001663_abnormal_digestive_system0.79382748
102MP0005595_abnormal_vascular_smooth0.78992151
103MP0010307_abnormal_tumor_latency0.78960357
104MP0003633_abnormal_nervous_system0.78824384
105MP0004782_abnormal_surfactant_physiolog0.76573566
106* MP0002135_abnormal_kidney_morphology0.75438822
107MP0005647_abnormal_sex_gland0.75089077
108MP0003828_pulmonary_edema0.73882707
109MP0004130_abnormal_muscle_cell0.72943014
110MP0003656_abnormal_erythrocyte_physiolo0.72776609
111MP0000538_abnormal_urinary_bladder0.71479698
112MP0003879_abnormal_hair_cell0.69845242
113MP0002877_abnormal_melanocyte_morpholog0.69319637
114MP0010155_abnormal_intestine_physiology0.68947395
115MP0005197_abnormal_uvea_morphology0.68932513
116MP0000609_abnormal_liver_physiology0.68387936
117* MP0002429_abnormal_blood_cell0.68331957
118MP0000858_altered_metastatic_potential0.67818758
119MP0002928_abnormal_bile_duct0.67582972
120MP0000371_diluted_coat_color0.66847313
121MP0005319_abnormal_enzyme/_coenzyme0.61085865
122MP0010386_abnormal_urinary_bladder0.58016426
123MP0008874_decreased_physiological_sensi0.56571136
124MP0001849_ear_inflammation0.55260581

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.48069465
2Increased cerebral lipofuscin (HP:0011813)6.40751930
3Glomerulonephritis (HP:0000099)6.37234168
4Abnormality of liposaccharide metabolism (HP:0010968)6.24992132
5Abnormality of glycosphingolipid metabolism (HP:0004343)6.24992132
6Abnormality of glycolipid metabolism (HP:0010969)6.24992132
7Dysostosis multiplex (HP:0000943)5.87911096
8Increased neuronal autofluorescent lipopigment (HP:0002074)5.59186272
9Vacuolated lymphocytes (HP:0001922)5.51858807
10Complement deficiency (HP:0004431)4.86193949
11Recurrent abscess formation (HP:0002722)4.57034114
12Axonal loss (HP:0003447)4.56911672
13Urinary glycosaminoglycan excretion (HP:0003541)4.45647851
14Mucopolysacchariduria (HP:0008155)4.45647851
15Abnormality of mucopolysaccharide metabolism (HP:0011020)4.22268825
16Abnormality of polysaccharide metabolism (HP:0011012)4.22268825
17Abnormality of glycosaminoglycan metabolism (HP:0004371)4.22268825
18Recurrent bacterial skin infections (HP:0005406)4.19806210
19Nuclear cataract (HP:0100018)4.19586871
20Abnormality of complement system (HP:0005339)3.91408609
21Eczematoid dermatitis (HP:0000976)3.86642739
22Disinhibition (HP:0000734)3.59699989
23Mutism (HP:0002300)3.58115258
24Abnormality of macrophages (HP:0004311)3.56734489
25Nephritis (HP:0000123)3.55689231
26Retinal atrophy (HP:0001105)3.54470410
27Cerebral aneurysm (HP:0004944)3.40886874
28Arterial tortuosity (HP:0005116)3.39430607
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.38558040
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.21623752
31Recurrent gram-negative bacterial infections (HP:0005420)3.13284007
32Vascular tortuosity (HP:0004948)3.04024005
33Asymmetric septal hypertrophy (HP:0001670)2.99052841
34Purpura (HP:0000979)2.97213281
35Loss of speech (HP:0002371)2.91351025
36Neuronal loss in central nervous system (HP:0002529)2.83966204
37Cerebral inclusion bodies (HP:0100314)2.83381714
38Hematochezia (HP:0002573)2.81305318
39Pathologic fracture (HP:0002756)2.76095584
40Hepatosplenomegaly (HP:0001433)2.63508313
41Orchitis (HP:0100796)2.59340571
42Metaphyseal irregularity (HP:0003025)2.58568124
43Upper motor neuron abnormality (HP:0002127)2.58083022
44Prolonged neonatal jaundice (HP:0006579)2.54046590
45Agnosia (HP:0010524)2.53772440
46Progressive neurologic deterioration (HP:0002344)2.49008025
47Increased serum ferritin (HP:0003281)2.48899944
48Peripheral demyelination (HP:0011096)2.44092890
49Retrobulbar optic neuritis (HP:0100654)2.42768226
50Optic neuritis (HP:0100653)2.42768226
51Myocardial infarction (HP:0001658)2.41586309
52Ovoid vertebral bodies (HP:0003300)2.38237657
53Aortic aneurysm (HP:0004942)2.37198643
54Spondylolisthesis (HP:0003302)2.35185516
55Stomatitis (HP:0010280)2.33095438
56J-shaped sella turcica (HP:0002680)2.32716422
57Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29550929
58Progressive visual loss (HP:0000529)2.27771375
59Autoimmune thrombocytopenia (HP:0001973)2.26631237
60Recurrent skin infections (HP:0001581)2.24134409
61Interstitial pulmonary disease (HP:0006530)2.22588401
62Thoracic kyphosis (HP:0002942)2.21704092
63Neurofibrillary tangles (HP:0002185)2.18345008
64Cardiomegaly (HP:0001640)2.17536885
65Abnormality of the lumbar spine (HP:0100712)2.16377312
66Striae distensae (HP:0001065)2.13320637
67Aortic dissection (HP:0002647)2.09914771
68Increased CSF protein (HP:0002922)2.09750296
69Apathy (HP:0000741)2.09412444
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.09244563
71Osteolytic defects of the hand bones (HP:0009699)2.09244563
72Colitis (HP:0002583)2.04641338
73Disproportionate tall stature (HP:0001519)2.04438740
74Basal ganglia calcification (HP:0002135)2.02002643
75Joint stiffness (HP:0001387)2.01937299
76Gingivitis (HP:0000230)2.01915389
77Diminished motivation (HP:0000745)2.01720307
78Polyneuropathy (HP:0001271)2.00539155
79Bone pain (HP:0002653)2.00224714
80Nausea (HP:0002018)1.99258060
81Multiple enchondromatosis (HP:0005701)1.98749118
82Beaking of vertebral bodies (HP:0004568)1.98129217
83Thick nail (HP:0001805)1.97931661
84Pulmonary infiltrates (HP:0002113)1.96824774
85Segmental peripheral demyelination/remyelination (HP:0003481)1.95717669
86Conjunctival telangiectasia (HP:0000524)1.95435132
87Global brain atrophy (HP:0002283)1.95055877
88Sensorimotor neuropathy (HP:0007141)1.94350314
89Myositis (HP:0100614)1.92443129
90Abnormality of iron homeostasis (HP:0011031)1.92020624
91Amyloidosis (HP:0011034)1.91798745
92Abnormality of the periventricular white matter (HP:0002518)1.91354479
93Supranuclear gaze palsy (HP:0000605)1.90719254
94Dementia (HP:0000726)1.87482662
95Malnutrition (HP:0004395)1.84291406
96Memory impairment (HP:0002354)1.82915960
97Cervical subluxation (HP:0003308)1.82499221
98Xanthomatosis (HP:0000991)1.81995783
99Zonular cataract (HP:0010920)1.81734782
100Impaired platelet aggregation (HP:0003540)1.79929785
101Abnormal platelet function (HP:0011869)1.79929785
102Metabolic alkalosis (HP:0200114)1.79658445
103Urethral obstruction (HP:0000796)1.78901584
104Mesangial abnormality (HP:0001966)1.77885818
105Mediastinal lymphadenopathy (HP:0100721)1.76339196
106Hypokalemic alkalosis (HP:0001949)1.76261568
107Hydroxyprolinuria (HP:0003080)1.74026309
108Abnormality of proline metabolism (HP:0010907)1.74026309
109Vertebral compression fractures (HP:0002953)1.73616344
110Personality changes (HP:0000751)1.72670771
111Spontaneous hematomas (HP:0007420)1.71626771
112Chronic obstructive pulmonary disease (HP:0006510)1.70042327
113Obstructive lung disease (HP:0006536)1.70042327
114Poor head control (HP:0002421)1.69786724
115Abnormality of the basal ganglia (HP:0002134)1.69605986
116Acrocyanosis (HP:0001063)1.69087671
117Clumsiness (HP:0002312)1.68296214
118Restrictive lung disease (HP:0002091)1.66284794
119Inappropriate behavior (HP:0000719)1.65662917
120Osteomyelitis (HP:0002754)1.65318703
121Abnormality of the nasal mucosa (HP:0000433)1.64316795
122Hypoplasia of the odontoid process (HP:0003311)1.63277435
123Elevated erythrocyte sedimentation rate (HP:0003565)1.62738248
124Mucosal telangiectasiae (HP:0100579)1.61596787
125Cellulitis (HP:0100658)1.61441306
126Chronic diarrhea (HP:0002028)1.60658504
127Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60136533
128Bone cyst (HP:0012062)1.59825618
129Petechiae (HP:0000967)1.59275098
130Protuberant abdomen (HP:0001538)1.57491073
131Hemoptysis (HP:0002105)1.56577262
132Urinary incontinence (HP:0000020)1.56539096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR27.10352177
2NME24.66484203
3CSF1R3.40832362
4DDR23.29086449
5BLK3.12243748
6GRK73.03089792
7TYK22.80530326
8ERN12.76610195
9TBK12.63465787
10TAOK22.50629655
11ACVR1B2.37366406
12MAPK152.28939396
13RIPK42.19983785
14KIT2.13961334
15PIM22.06786475
16PAK42.03368753
17EPHB11.90796940
18ABL21.87342426
19NEK91.84790547
20PKN21.81071278
21JAK11.80059144
22CAMK1D1.79035733
23PDK21.76243780
24TAOK11.71175308
25SCYL21.69020648
26CAMKK21.67255317
27MAP3K141.61626463
28TRIB31.59723558
29TESK11.54063258
30IRAK41.52590156
31PRPF4B1.49255561
32IRAK31.48333917
33CDC42BPA1.48273727
34STK101.43620076
35MAP4K11.40474180
36MOS1.39137727
37MATK1.35156104
38TESK21.27586026
39ZAP701.23973613
40HCK1.20555795
41JAK21.20157212
42WNK41.18476938
43CAMKK11.16929360
44MAP2K31.16310033
45CAMK1G1.15608192
46IKBKB1.09451537
47CSK1.08814486
48OXSR11.07988153
49TSSK61.05468869
50MAP3K31.05397613
51FES1.04578390
52EPHB21.02683655
53FGR1.02204622
54TGFBR11.01191322
55PTK61.00715890
56BMPR20.97890579
57MAPK120.91924190
58LYN0.91820335
59MAP3K10.89852740
60IKBKE0.87913089
61CLK10.86076871
62LIMK10.85779101
63SYK0.84760240
64MAP2K60.81417011
65BMX0.78893267
66LCK0.77295226
67MAP3K50.75789280
68KDR0.75095251
69PDK10.73553271
70PDGFRA0.72603389
71DAPK20.70138921
72EGFR0.70085662
73TYRO30.68861423
74IRAK20.68720615
75PDPK10.68028422
76FGFR40.67290594
77GSK3A0.65668251
78TTN0.63739410
79RIPK10.63457888
80PTK2B0.63217790
81ITK0.61515461
82MAP3K130.61363968
83LRRK20.60342093
84PRKCD0.59310407
85WNK30.58491037
86IGF1R0.58236053
87IRAK10.57903022
88DAPK30.57766165
89SGK30.54855021
90TRPM70.53721689
91TXK0.52491732
92KSR20.52209836
93RET0.51818704
94GRK50.51701574
95BTK0.51672342
96MAPK70.51481056
97JAK30.49382636
98ICK0.48799879
99MARK30.47356478
100MAPK40.45860648
101PAK20.44946024
102MAPKAPK20.44149285
103PRKCH0.43294873
104MAP3K90.42961647
105PRKG20.42802005
106MAP3K110.42732226
107LATS20.42357867
108CAMK40.42209461
109INSR0.41665790
110LMTK20.39267393
111NTRK10.39163452
112ARAF0.39090111
113CHUK0.37849557
114WNK10.37848061
115RPS6KL10.37811979
116RPS6KC10.37811979
117SGK4940.37775182
118SGK2230.37775182
119ABL10.37029392
120PIM10.35459451
121SIK30.35127116
122MAP3K20.34085753
123PIK3CG0.32485576
124FYN0.32023337
125FGFR30.31444455
126PRKD10.31066398
127CDK60.31002271
128RPS6KA60.30793774
129BCKDK0.29458642
130SRC0.29309030
131PKN10.27892398
132ADRBK20.27529589
133MAP2K20.26829403
134DYRK30.26467884
135RPS6KA20.26256155
136MAPKAPK30.24357305
137SIK10.20943452
138MAP3K80.17959759
139CDK150.16909165

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.96636484
2Other glycan degradation_Homo sapiens_hsa005114.58280470
3Staphylococcus aureus infection_Homo sapiens_hsa051504.37015909
4* Lysosome_Homo sapiens_hsa041424.13861189
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.92907378
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.47038768
7Osteoclast differentiation_Homo sapiens_hsa043802.23206651
8Autoimmune thyroid disease_Homo sapiens_hsa053202.14070542
9Leishmaniasis_Homo sapiens_hsa051402.07359925
10Pertussis_Homo sapiens_hsa051332.06158730
11Phagosome_Homo sapiens_hsa041451.94473306
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84039077
13Tuberculosis_Homo sapiens_hsa051521.79276458
14Type I diabetes mellitus_Homo sapiens_hsa049401.71846380
15Prion diseases_Homo sapiens_hsa050201.68697802
16Rheumatoid arthritis_Homo sapiens_hsa053231.61843733
17Complement and coagulation cascades_Homo sapiens_hsa046101.60322665
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59006796
19Collecting duct acid secretion_Homo sapiens_hsa049661.55822949
20B cell receptor signaling pathway_Homo sapiens_hsa046621.48883973
21Malaria_Homo sapiens_hsa051441.47850941
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32260176
23Legionellosis_Homo sapiens_hsa051341.31245192
24Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17920459
25Toxoplasmosis_Homo sapiens_hsa051451.17140548
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16843467
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16810824
28Salmonella infection_Homo sapiens_hsa051321.14038730
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05447183
30* Antigen processing and presentation_Homo sapiens_hsa046121.03081597
31Endocytosis_Homo sapiens_hsa041441.02333648
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01772616
33Mineral absorption_Homo sapiens_hsa049780.93050021
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88022727
35Apoptosis_Homo sapiens_hsa042100.86917205
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85826848
37Leukocyte transendothelial migration_Homo sapiens_hsa046700.85381725
38Chemokine signaling pathway_Homo sapiens_hsa040620.84182773
39Herpes simplex infection_Homo sapiens_hsa051680.83663382
40Bladder cancer_Homo sapiens_hsa052190.82850263
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.82326164
42Sphingolipid metabolism_Homo sapiens_hsa006000.80577618
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80335587
44Measles_Homo sapiens_hsa051620.78752097
45Sulfur metabolism_Homo sapiens_hsa009200.78589290
46Influenza A_Homo sapiens_hsa051640.78395345
47Shigellosis_Homo sapiens_hsa051310.78133844
48Nitrogen metabolism_Homo sapiens_hsa009100.76558244
49Amoebiasis_Homo sapiens_hsa051460.76429590
50Renin-angiotensin system_Homo sapiens_hsa046140.73792061
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69595354
52Vibrio cholerae infection_Homo sapiens_hsa051100.69371173
53Pancreatic cancer_Homo sapiens_hsa052120.69344506
54Hematopoietic cell lineage_Homo sapiens_hsa046400.68738198
55Synaptic vesicle cycle_Homo sapiens_hsa047210.68661304
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67732446
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66322987
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.65558367
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63780291
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62709750
61Platelet activation_Homo sapiens_hsa046110.60501820
62Systemic lupus erythematosus_Homo sapiens_hsa053220.58115414
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58039067
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57536446
65TNF signaling pathway_Homo sapiens_hsa046680.57448473
66Chronic myeloid leukemia_Homo sapiens_hsa052200.55970446
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54965904
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54775024
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54533155
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.54484809
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53777774
72Vitamin digestion and absorption_Homo sapiens_hsa049770.52888990
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52636394
74Ether lipid metabolism_Homo sapiens_hsa005650.52100666
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51149651
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48689251
77Tryptophan metabolism_Homo sapiens_hsa003800.46686225
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46328869
79ABC transporters_Homo sapiens_hsa020100.46146100
80Glutathione metabolism_Homo sapiens_hsa004800.45637032
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.44996200
82Epstein-Barr virus infection_Homo sapiens_hsa051690.44936523
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44788630
84Hepatitis C_Homo sapiens_hsa051600.43978201
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42478715
86Hepatitis B_Homo sapiens_hsa051610.42137101
87African trypanosomiasis_Homo sapiens_hsa051430.42024036
88Focal adhesion_Homo sapiens_hsa045100.41089494
89PPAR signaling pathway_Homo sapiens_hsa033200.40673866
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.40363134
91Primary immunodeficiency_Homo sapiens_hsa053400.37558635
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.37301838
93Starch and sucrose metabolism_Homo sapiens_hsa005000.37162547
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35989532
95Renal cell carcinoma_Homo sapiens_hsa052110.35756458
96Arachidonic acid metabolism_Homo sapiens_hsa005900.35370787
97Caffeine metabolism_Homo sapiens_hsa002320.35311476
98HIF-1 signaling pathway_Homo sapiens_hsa040660.35159309
99Acute myeloid leukemia_Homo sapiens_hsa052210.34871730
100Asthma_Homo sapiens_hsa053100.33846997
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.32982453
102ECM-receptor interaction_Homo sapiens_hsa045120.31256045
103Proteoglycans in cancer_Homo sapiens_hsa052050.30848143
104Bile secretion_Homo sapiens_hsa049760.30785621
105Fructose and mannose metabolism_Homo sapiens_hsa000510.29350787
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.27218363
107Viral myocarditis_Homo sapiens_hsa054160.27114645
108Prolactin signaling pathway_Homo sapiens_hsa049170.26789547
109Steroid biosynthesis_Homo sapiens_hsa001000.25860744
110T cell receptor signaling pathway_Homo sapiens_hsa046600.25636257
111Allograft rejection_Homo sapiens_hsa053300.24989442
112Galactose metabolism_Homo sapiens_hsa000520.23223520
113VEGF signaling pathway_Homo sapiens_hsa043700.20855701
114Adherens junction_Homo sapiens_hsa045200.20469060
115Graft-versus-host disease_Homo sapiens_hsa053320.20298998
116Rap1 signaling pathway_Homo sapiens_hsa040150.19610946
117Inositol phosphate metabolism_Homo sapiens_hsa005620.18827502
118HTLV-I infection_Homo sapiens_hsa051660.17961872
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17661899
120Type II diabetes mellitus_Homo sapiens_hsa049300.13564174
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12149904
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10082641
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07031342
124Viral carcinogenesis_Homo sapiens_hsa052030.03897273
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.01921202
126Insulin resistance_Homo sapiens_hsa049310.00163124

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