LGMNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide catabolic process (GO:0009313)4.79035359
2regulation of mononuclear cell migration (GO:0071675)4.42990641
3glycosphingolipid catabolic process (GO:0046479)4.29674615
4glycolipid catabolic process (GO:0019377)4.06071513
5proteasome assembly (GO:0043248)4.00329483
6amino sugar catabolic process (GO:0046348)3.92254484
7negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.90273987
8N-acetylneuraminate metabolic process (GO:0006054)3.80333727
9keratan sulfate catabolic process (GO:0042340)3.79450324
10neutrophil activation involved in immune response (GO:0002283)3.77338935
11protein maturation by protein folding (GO:0022417)3.76231132
12membrane lipid catabolic process (GO:0046466)3.59367193
13phagosome maturation (GO:0090382)3.55668973
14sphingolipid catabolic process (GO:0030149)3.54646061
15immunoglobulin mediated immune response (GO:0016064)3.53980770
16ceramide catabolic process (GO:0046514)3.53913143
17platelet dense granule organization (GO:0060155)3.48533659
18positive regulation of mast cell degranulation (GO:0043306)3.44199659
19positive regulation of mast cell activation involved in immune response (GO:0033008)3.44199659
20positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.44055312
21vitamin D metabolic process (GO:0042359)3.38399657
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.36606347
23ATP hydrolysis coupled proton transport (GO:0015991)3.36606347
24negative regulation of interleukin-12 production (GO:0032695)3.34427886
25cellular response to thyroid hormone stimulus (GO:0097067)3.33303932
26negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.32849147
27response to hydroperoxide (GO:0033194)3.28144369
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.27471103
29energy homeostasis (GO:0097009)3.27154872
30positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.26702932
31positive regulation of chemokine biosynthetic process (GO:0045080)3.25723872
32lactate metabolic process (GO:0006089)3.23492076
33respiratory chain complex IV assembly (GO:0008535)3.22728312
34regulation of cytokine secretion involved in immune response (GO:0002739)3.17304293
35xenobiotic catabolic process (GO:0042178)3.16085506
36positive regulation of leukocyte degranulation (GO:0043302)3.14870389
37C-terminal protein lipidation (GO:0006501)3.10542906
38transferrin transport (GO:0033572)3.09408328
39regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.04981850
40positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.04345997
41positive regulation of monocyte chemotaxis (GO:0090026)3.02976346
42response to acidic pH (GO:0010447)3.02167809
43mature B cell differentiation involved in immune response (GO:0002313)3.00268141
44interferon-gamma-mediated signaling pathway (GO:0060333)2.96859751
45cytochrome complex assembly (GO:0017004)2.96641156
46cellular response to zinc ion (GO:0071294)2.92961584
47lysosome organization (GO:0007040)2.88895074
48lytic vacuole organization (GO:0080171)2.88895074
49antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88549224
50negative regulation of cation channel activity (GO:2001258)2.86693108
51B cell mediated immunity (GO:0019724)2.86095861
52positive regulation of actin filament depolymerization (GO:0030836)2.85257811
53negative regulation of nitric oxide biosynthetic process (GO:0045019)2.84902596
54regulation of inflammatory response to antigenic stimulus (GO:0002861)2.84711291
55ferric iron transport (GO:0015682)2.84195746
56trivalent inorganic cation transport (GO:0072512)2.84195746
57positive regulation of mast cell activation (GO:0033005)2.80592836
58regulation of type B pancreatic cell apoptotic process (GO:2000674)2.79447256
59fat-soluble vitamin biosynthetic process (GO:0042362)2.77409294
60C-terminal protein amino acid modification (GO:0018410)2.77188851
61positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72827028
62L-alpha-amino acid transmembrane transport (GO:1902475)2.70777654
63response to thyroid hormone (GO:0097066)2.70607687
64positive regulation of toll-like receptor signaling pathway (GO:0034123)2.69204067
65intracellular pH reduction (GO:0051452)2.67247111
66antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66091448
67pH reduction (GO:0045851)2.65620288
68regulation of chemokine biosynthetic process (GO:0045073)2.64505436
69positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64441549
70vitamin biosynthetic process (GO:0009110)2.63409540
71regulation of cellular amino acid metabolic process (GO:0006521)2.62154844
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.59677766
73glycerophospholipid catabolic process (GO:0046475)2.55170637
74glucosamine-containing compound catabolic process (GO:1901072)2.54683228
75negative regulation of mast cell activation (GO:0033004)2.54544798
76cellular response to arsenic-containing substance (GO:0071243)2.54150143
77endosome to melanosome transport (GO:0035646)2.54042119
78endosome to pigment granule transport (GO:0043485)2.54042119
79purine nucleotide salvage (GO:0032261)2.52683611
80cellular response to interferon-gamma (GO:0071346)2.50067483
81water-soluble vitamin biosynthetic process (GO:0042364)2.49409786
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48765088
83regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.48313678
84response to interferon-gamma (GO:0034341)2.46931952
85histamine secretion (GO:0001821)2.46220189
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.45587708
87positive regulation of calcium ion import (GO:0090280)2.45281940
88virion attachment to host cell (GO:0019062)2.44051851
89adhesion of symbiont to host cell (GO:0044650)2.44051851
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43772699
91regulation of podosome assembly (GO:0071801)2.42706122
92mitochondrial calcium ion homeostasis (GO:0051560)2.42307798
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.41833902
94negative regulation of myeloid cell apoptotic process (GO:0033033)2.41228385
95endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40616376
96chaperone mediated protein folding requiring cofactor (GO:0051085)2.40519331
97mature B cell differentiation (GO:0002335)2.38817883
98T-helper 1 type immune response (GO:0042088)2.38177431
99vasodilation (GO:0042311)2.37835488
100positive regulation of interleukin-6 production (GO:0032755)2.37129859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.94657311
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.64212995
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09920965
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.90193512
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21805549
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.14561019
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.92806266
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77804983
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.70996569
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.49185092
11TFEB_21752829_ChIP-Seq_HELA_Human2.46644216
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.43638163
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43433721
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.41208948
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29890396
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28415964
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17296013
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06538539
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06234190
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05752200
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02095719
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01805229
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98038446
24VDR_23849224_ChIP-Seq_CD4+_Human1.91887989
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.91228344
26ELK1_19687146_ChIP-ChIP_HELA_Human1.90338523
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89281388
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86755751
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81387826
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66816489
31DCP1A_22483619_ChIP-Seq_HELA_Human1.63615605
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63386117
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61195681
34SPI1_23547873_ChIP-Seq_NB4_Human1.56329299
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56287589
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52201198
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52018270
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50939453
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50688226
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48200963
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44310800
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43348406
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39488727
44TAF15_26573619_Chip-Seq_HEK293_Human1.38324754
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37699397
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36257575
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35268048
48HTT_18923047_ChIP-ChIP_STHdh_Human1.26642724
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21943414
50SOX2_19829295_ChIP-Seq_ESCs_Human1.21253281
51NANOG_19829295_ChIP-Seq_ESCs_Human1.21253281
52CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17138522
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16780188
54FOXP3_21729870_ChIP-Seq_TREG_Human1.15978957
55ZNF274_21170338_ChIP-Seq_K562_Hela1.15804512
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15423339
57STAT1_20625510_ChIP-Seq_HELA_Human1.14308783
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13862899
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11399107
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11319882
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11100702
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11053309
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08050604
64AR_20517297_ChIP-Seq_VCAP_Human1.07354715
65SOX2_20726797_ChIP-Seq_SW620_Human1.06710929
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02836940
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.01830511
68GABP_19822575_ChIP-Seq_HepG2_Human1.01453954
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98524601
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98023897
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97656912
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97517327
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97382531
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95964847
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95390101
76FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94678835
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94330293
78PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93128731
79ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93108091
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92535348
81ELF5_23300383_ChIP-Seq_T47D_Human0.91515357
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.91422197
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90968206
84VDR_22108803_ChIP-Seq_LS180_Human0.90309111
85CBP_21632823_ChIP-Seq_H3396_Human0.89387673
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88180105
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.88125789
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88079246
89GATA3_26560356_Chip-Seq_TH2_Human0.87499250
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87160908
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86804191
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86742355
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.86742355
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84518609
95NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83849229
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82925461
97P300_19829295_ChIP-Seq_ESCs_Human0.81319417
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79256028
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78759062
100TP53_22573176_ChIP-Seq_HFKS_Human0.78023652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.50814275
2MP0006082_CNS_inflammation3.86490966
3MP0009840_abnormal_foam_cell3.51367159
4MP0002837_dystrophic_cardiac_calcinosis3.42818191
5MP0002139_abnormal_hepatobiliary_system3.20900286
6MP0006054_spinal_hemorrhage2.94547088
7MP0003195_calcinosis2.82502098
8MP0003075_altered_response_to2.72184824
9MP0002148_abnormal_hypersensitivity_rea2.71950825
10MP0000343_altered_response_to2.62678399
11MP0009785_altered_susceptibility_to2.56489981
12MP0003303_peritoneal_inflammation2.52746968
13MP0003724_increased_susceptibility_to2.44738251
14MP0001835_abnormal_antigen_presentation2.40526115
15MP0009764_decreased_sensitivity_to2.36243298
16MP0003172_abnormal_lysosome_physiology2.26864909
17MP0005167_abnormal_blood-brain_barrier2.17606095
18MP0004510_myositis2.16329999
19MP0002090_abnormal_vision2.13351968
20MP0002254_reproductive_system_inflammat2.12167772
21MP0003806_abnormal_nucleotide_metabolis2.01311305
22MP0005379_endocrine/exocrine_gland_phen1.91597138
23MP0001853_heart_inflammation1.90724707
24MP0002419_abnormal_innate_immunity1.83465882
25MP0010234_abnormal_vibrissa_follicle1.77230640
26MP0003191_abnormal_cellular_cholesterol1.71592265
27MP0005365_abnormal_bile_salt1.70871277
28MP0000685_abnormal_immune_system1.68501493
29MP0003436_decreased_susceptibility_to1.65314420
30MP0005671_abnormal_response_to1.61146087
31MP0008469_abnormal_protein_level1.60768319
32MP0005000_abnormal_immune_tolerance1.60301429
33MP0001533_abnormal_skeleton_physiology1.58082472
34MP0000604_amyloidosis1.52742453
35MP0002452_abnormal_antigen_presenting1.51097827
36MP0006072_abnormal_retinal_apoptosis1.49645004
37MP0006036_abnormal_mitochondrial_physio1.46872302
38MP0001790_abnormal_immune_system1.45443982
39MP0005387_immune_system_phenotype1.45443982
40MP0003186_abnormal_redox_activity1.44754733
41MP0005165_increased_susceptibility_to1.43962869
42MP0001845_abnormal_inflammatory_respons1.41166991
43MP0005166_decreased_susceptibility_to1.40207971
44MP0002693_abnormal_pancreas_physiology1.38657071
45MP0000516_abnormal_urinary_system1.37034416
46MP0005367_renal/urinary_system_phenotyp1.37034416
47MP0004019_abnormal_vitamin_homeostasis1.34045529
48MP0005025_abnormal_response_to1.30932180
49MP0001764_abnormal_homeostasis1.30322712
50MP0002332_abnormal_exercise_endurance1.26478385
51MP0008875_abnormal_xenobiotic_pharmacok1.25889025
52MP0002723_abnormal_immune_serum1.23513478
53MP0005084_abnormal_gallbladder_morpholo1.22395958
54MP0010386_abnormal_urinary_bladder1.22148146
55MP0001542_abnormal_bone_strength1.22044136
56MP0001756_abnormal_urination1.20455194
57MP0005397_hematopoietic_system_phenotyp1.18297656
58MP0001545_abnormal_hematopoietic_system1.18297656
59MP0005332_abnormal_amino_acid1.12922394
60MP0003011_delayed_dark_adaptation1.12346050
61MP0002909_abnormal_adrenal_gland1.06686879
62MP0002998_abnormal_bone_remodeling1.03046523
63MP0002163_abnormal_gland_morphology1.01352302
64MP0005310_abnormal_salivary_gland1.01293475
65MP0005451_abnormal_body_composition0.98823618
66MP0003690_abnormal_glial_cell0.97972369
67MP0001800_abnormal_humoral_immune0.97310445
68MP0009046_muscle_twitch0.95656088
69MP0000920_abnormal_myelination0.95169158
70MP0000858_altered_metastatic_potential0.92823091
71MP0001819_abnormal_immune_cell0.91336971
72MP0005464_abnormal_platelet_physiology0.90815489
73MP0002420_abnormal_adaptive_immunity0.89929686
74MP0005253_abnormal_eye_physiology0.88018739
75MP0002277_abnormal_respiratory_mucosa0.87625080
76MP0003300_gastrointestinal_ulcer0.86984660
77MP0004147_increased_porphyrin_level0.84204214
78MP0009333_abnormal_splenocyte_physiolog0.82331757
79MP0006035_abnormal_mitochondrial_morpho0.81567842
80MP0001243_abnormal_dermal_layer0.78934800
81MP0003448_altered_tumor_morphology0.78695328
82MP0005257_abnormal_intraocular_pressure0.78005568
83MP0010329_abnormal_lipoprotein_level0.76911257
84MP0003633_abnormal_nervous_system0.76673950
85MP0005584_abnormal_enzyme/coenzyme_acti0.76390826
86MP0000647_abnormal_sebaceous_gland0.74383975
87MP0009763_increased_sensitivity_to0.72408067
88MP0005636_abnormal_mineral_homeostasis0.72260923
89MP0010155_abnormal_intestine_physiology0.70422208
90MP0005535_abnormal_body_temperature0.69850871
91MP0001727_abnormal_embryo_implantation0.68912475
92MP0003795_abnormal_bone_structure0.67865350
93MP0001905_abnormal_dopamine_level0.67853723
94MP0003453_abnormal_keratinocyte_physiol0.67751324
95MP0009643_abnormal_urine_homeostasis0.64981534
96MP0000747_muscle_weakness0.64971946
97MP0000358_abnormal_cell_content/0.63341814
98MP0002295_abnormal_pulmonary_circulatio0.62085044
99MP0008260_abnormal_autophagy0.61933436
100MP0002118_abnormal_lipid_homeostasis0.61241111

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)8.34906673
2Abnormality of glycosphingolipid metabolism (HP:0004343)8.34906673
3Abnormality of glycolipid metabolism (HP:0010969)8.34906673
4Vacuolated lymphocytes (HP:0001922)6.63515761
5Dysostosis multiplex (HP:0000943)4.06087438
6Loss of speech (HP:0002371)4.04729304
7Nuclear cataract (HP:0100018)3.90519177
8Increased cerebral lipofuscin (HP:0011813)3.88053577
9Progressive neurologic deterioration (HP:0002344)3.56216674
10Abnormality of macrophages (HP:0004311)3.48031462
11Mutism (HP:0002300)3.47262628
12Disinhibition (HP:0000734)3.31607420
13Hypoglycemic seizures (HP:0002173)3.29926816
14Hyperinsulinemic hypoglycemia (HP:0000825)3.17367880
15Prolonged neonatal jaundice (HP:0006579)3.16903228
16Hypoglycemic coma (HP:0001325)3.15186610
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.13869310
18Abnormality of polysaccharide metabolism (HP:0011012)3.13869310
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.13869310
20Mucopolysacchariduria (HP:0008155)3.01173199
21Urinary glycosaminoglycan excretion (HP:0003541)3.01173199
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.98188958
23Systemic lupus erythematosus (HP:0002725)2.96853927
24Symptomatic seizures (HP:0011145)2.90532840
25Hepatic necrosis (HP:0002605)2.84532580
26Ketoacidosis (HP:0001993)2.79301622
27Hepatocellular necrosis (HP:0001404)2.73652708
28Hyperglycemia (HP:0003074)2.70096714
29Acute necrotizing encephalopathy (HP:0006965)2.61890827
30Hypothermia (HP:0002045)2.61629228
31Mitochondrial inheritance (HP:0001427)2.60785989
32Increased CSF lactate (HP:0002490)2.52933562
33Large for gestational age (HP:0001520)2.50372213
34Progressive macrocephaly (HP:0004481)2.46259409
35Hypokinesia (HP:0002375)2.45115503
36Recurrent abscess formation (HP:0002722)2.43890542
37Hematochezia (HP:0002573)2.40674978
38Abnormal mitochondria in muscle tissue (HP:0008316)2.39863946
39Retinal atrophy (HP:0001105)2.39598033
40Tongue fasciculations (HP:0001308)2.37732723
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.37421683
42Generalized aminoaciduria (HP:0002909)2.35327154
43Lipid accumulation in hepatocytes (HP:0006561)2.33636081
44Axonal loss (HP:0003447)2.31125901
45Recurrent bacterial skin infections (HP:0005406)2.30113583
46Neurofibrillary tangles (HP:0002185)2.28936913
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.27494603
48Respiratory failure (HP:0002878)2.25938624
49Cardiomegaly (HP:0001640)2.24262106
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23665713
51Acute encephalopathy (HP:0006846)2.23277210
52Zonular cataract (HP:0010920)2.22972520
53Abnormality of the basal ganglia (HP:0002134)2.20246678
54Diminished motivation (HP:0000745)2.19381741
55Increased hepatocellular lipid droplets (HP:0006565)2.17814588
56Insulin-resistant diabetes mellitus (HP:0000831)2.16633736
57Renal Fanconi syndrome (HP:0001994)2.15931335
58Myocardial infarction (HP:0001658)2.15024518
59Increased CSF protein (HP:0002922)2.14838087
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14737278
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14737278
62Apathy (HP:0000741)2.12316732
63CNS demyelination (HP:0007305)2.10942886
64Metaphyseal irregularity (HP:0003025)2.08695662
65Late onset (HP:0003584)2.07903020
66Stomatitis (HP:0010280)2.07718511
67Xanthomatosis (HP:0000991)2.07716869
68Global brain atrophy (HP:0002283)2.07648143
69Hepatosplenomegaly (HP:0001433)2.06102545
70Nausea (HP:0002018)2.04894231
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04296224
72Exertional dyspnea (HP:0002875)2.00620173
73Poor head control (HP:0002421)1.99842842
74Petechiae (HP:0000967)1.95847683
75Prominent metopic ridge (HP:0005487)1.94173681
76Amyloidosis (HP:0011034)1.93603091
77Autoimmune thrombocytopenia (HP:0001973)1.92883299
78Type I transferrin isoform profile (HP:0003642)1.90060636
79Degeneration of anterior horn cells (HP:0002398)1.89623473
80Abnormality of the anterior horn cell (HP:0006802)1.89623473
81Abnormality of the pancreatic islet cells (HP:0006476)1.89018900
82Abnormality of endocrine pancreas physiology (HP:0012093)1.89018900
83Sensorimotor neuropathy (HP:0007141)1.88953443
84Muscle fibrillation (HP:0010546)1.88290456
85Polyneuropathy (HP:0001271)1.87185385
86Agitation (HP:0000713)1.86038485
87Azoospermia (HP:0000027)1.84212360
88Abnormality of fatty-acid metabolism (HP:0004359)1.83397596
89Basal ganglia calcification (HP:0002135)1.83340626
90Glomerulonephritis (HP:0000099)1.82389702
91Polyphagia (HP:0002591)1.82227985
92Increased serum pyruvate (HP:0003542)1.81976748
93Pancreatic islet-cell hyperplasia (HP:0004510)1.80456965
94Ketosis (HP:0001946)1.76718364
95Increased serum ferritin (HP:0003281)1.76490922
96Lactic acidosis (HP:0003128)1.76254836
97Cerebral edema (HP:0002181)1.75930622
98Multiple enchondromatosis (HP:0005701)1.75804756
993-Methylglutaconic aciduria (HP:0003535)1.75344576
100Beaking of vertebral bodies (HP:0004568)1.74358769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.35743092
2MAP3K123.07756557
3TESK13.04866231
4NME23.01159851
5LIMK12.62083246
6MST42.60623063
7BMPR22.50601423
8BCKDK2.39647443
9IRAK32.38732792
10FRK2.30301979
11TRIM282.04706924
12GRK71.91473790
13CSNK1G31.90919450
14BLK1.89382990
15PIM21.81649150
16ADRBK21.77686339
17TGFBR21.76704416
18DAPK11.75623703
19ACVR1B1.68564330
20CSNK1A1L1.60349963
21CSNK1G11.60036685
22TESK21.56438017
23CSNK1G21.54547368
24GRK11.53448718
25CDK191.50601298
26CAMKK21.47148132
27ERBB31.44447699
28DAPK21.41309855
29PAK41.40754611
30NUAK11.39097325
31ZAK1.35546324
32TBK11.35166622
33ARAF1.33015291
34WNK31.32316255
35STK161.28833498
36MYLK1.28817095
37ABL21.27451692
38MAP4K21.24683939
39BUB11.14729961
40FER1.13499682
41PHKG11.12547698
42PHKG21.12547698
43MAPKAPK31.10143600
44IKBKB1.08429551
45DDR21.05714581
46MATK1.04520420
47TNIK1.04214411
48TYK21.03277534
49PLK20.99806721
50MAP2K70.98981011
51TLK10.98838644
52OXSR10.97814521
53MOS0.94082197
54SCYL20.93493143
55CSF1R0.90817678
56PLK30.89100096
57IRAK40.87594695
58CCNB10.87138266
59VRK20.86479556
60MAP2K60.85814775
61MAP3K140.84112012
62TAOK20.82955827
63BMPR1B0.81414941
64FGR0.79094871
65TRPM70.77750525
66DAPK30.75943806
67EIF2AK30.73975599
68MAP3K110.72781953
69JAK30.71773876
70BCR0.68912391
71ERBB40.65057346
72STK100.62766064
73SIK30.61483711
74TGFBR10.59617241
75MAP3K50.59519397
76MAP3K40.58377714
77TEC0.57889475
78INSRR0.55581590
79PRKCE0.54770051
80ABL10.52512189
81CHUK0.51887912
82PLK40.49374451
83NEK10.49350114
84LYN0.49022156
85KDR0.48432209
86IRAK10.48304482
87MAPKAPK50.48007577
88TAOK30.47817957
89CAMK2D0.47076713
90VRK10.44689089
91PAK10.42626800
92LMTK20.38674120
93ILK0.38195094
94ERN10.37511427
95CSNK1A10.37420948
96IRAK20.36867622
97EIF2AK10.36042568
98EPHA20.35033760
99CAMK2G0.34913193
100RPS6KA40.34791324

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.90402696
2Other glycan degradation_Homo sapiens_hsa005113.68467815
3Lysosome_Homo sapiens_hsa041423.07312191
4Type I diabetes mellitus_Homo sapiens_hsa049403.01681473
5Rheumatoid arthritis_Homo sapiens_hsa053232.99186397
6Allograft rejection_Homo sapiens_hsa053302.85840238
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.77845712
8Proteasome_Homo sapiens_hsa030502.68032875
9Autoimmune thyroid disease_Homo sapiens_hsa053202.49139647
10Graft-versus-host disease_Homo sapiens_hsa053322.44854926
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.43610979
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.42852931
13Oxidative phosphorylation_Homo sapiens_hsa001902.36959915
14Staphylococcus aureus infection_Homo sapiens_hsa051502.36513858
15Collecting duct acid secretion_Homo sapiens_hsa049662.24069816
16Antigen processing and presentation_Homo sapiens_hsa046122.13522540
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06280522
18Protein export_Homo sapiens_hsa030601.94755128
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.83931631
20Fatty acid elongation_Homo sapiens_hsa000621.74826378
21Leishmaniasis_Homo sapiens_hsa051401.65863456
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63891378
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59466938
24Phagosome_Homo sapiens_hsa041451.57348796
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55197805
26Vibrio cholerae infection_Homo sapiens_hsa051101.46231382
27Tuberculosis_Homo sapiens_hsa051521.40222748
28Legionellosis_Homo sapiens_hsa051341.33696211
29Viral myocarditis_Homo sapiens_hsa054161.32556474
30Parkinsons disease_Homo sapiens_hsa050121.31811879
31Sulfur metabolism_Homo sapiens_hsa009201.27509143
32Glutathione metabolism_Homo sapiens_hsa004801.26841030
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16152615
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.15304438
35Pertussis_Homo sapiens_hsa051331.10610947
36Mineral absorption_Homo sapiens_hsa049781.06807156
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05513866
38Galactose metabolism_Homo sapiens_hsa000521.05252386
39Salmonella infection_Homo sapiens_hsa051321.02095100
40Tryptophan metabolism_Homo sapiens_hsa003801.00789666
41Steroid biosynthesis_Homo sapiens_hsa001000.99546173
42Regulation of autophagy_Homo sapiens_hsa041400.97880916
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97285464
44Alzheimers disease_Homo sapiens_hsa050100.96892750
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95674590
46Sphingolipid metabolism_Homo sapiens_hsa006000.95155706
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95089889
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94621147
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90750463
50Synaptic vesicle cycle_Homo sapiens_hsa047210.87805095
51Vitamin B6 metabolism_Homo sapiens_hsa007500.84206478
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83021166
53Peroxisome_Homo sapiens_hsa041460.81748551
54Folate biosynthesis_Homo sapiens_hsa007900.80170333
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79285505
56Toxoplasmosis_Homo sapiens_hsa051450.78711152
57Selenocompound metabolism_Homo sapiens_hsa004500.70913098
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69676450
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69499706
60Huntingtons disease_Homo sapiens_hsa050160.69320896
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66228606
62Influenza A_Homo sapiens_hsa051640.64387804
63Malaria_Homo sapiens_hsa051440.62681767
64Butanoate metabolism_Homo sapiens_hsa006500.61505068
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.60884157
66Herpes simplex infection_Homo sapiens_hsa051680.58365797
67Osteoclast differentiation_Homo sapiens_hsa043800.56116667
68Shigellosis_Homo sapiens_hsa051310.54723385
69Fatty acid metabolism_Homo sapiens_hsa012120.54402486
70Pyruvate metabolism_Homo sapiens_hsa006200.54009276
71Hematopoietic cell lineage_Homo sapiens_hsa046400.51374195
72Propanoate metabolism_Homo sapiens_hsa006400.48727899
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48674027
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.43853799
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42160779
76Fatty acid degradation_Homo sapiens_hsa000710.41601798
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38013686
78Homologous recombination_Homo sapiens_hsa034400.37370606
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37144287
80Metabolic pathways_Homo sapiens_hsa011000.36651910
81Systemic lupus erythematosus_Homo sapiens_hsa053220.36524548
82African trypanosomiasis_Homo sapiens_hsa051430.35844536
83RNA polymerase_Homo sapiens_hsa030200.34159487
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34044353
85Carbon metabolism_Homo sapiens_hsa012000.33882760
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33538682
87Epstein-Barr virus infection_Homo sapiens_hsa051690.31985687
88Complement and coagulation cascades_Homo sapiens_hsa046100.31514324
89Ether lipid metabolism_Homo sapiens_hsa005650.31254537
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31145698
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30632199
92Renin-angiotensin system_Homo sapiens_hsa046140.28943411
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28815708
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26818764
95PPAR signaling pathway_Homo sapiens_hsa033200.26193197
96N-Glycan biosynthesis_Homo sapiens_hsa005100.24773708
97beta-Alanine metabolism_Homo sapiens_hsa004100.24454555
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23691699
99Fructose and mannose metabolism_Homo sapiens_hsa000510.22801992
100TNF signaling pathway_Homo sapiens_hsa046680.20721040

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »