LGR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1uronic acid metabolic process (GO:0006063)6.08353833
2glucuronate metabolic process (GO:0019585)6.08353833
3cellular glucuronidation (GO:0052695)5.88429170
4xenobiotic catabolic process (GO:0042178)5.44605693
5glyoxylate metabolic process (GO:0046487)5.07002839
6phenylpropanoid metabolic process (GO:0009698)4.93442617
7response to nitrosative stress (GO:0051409)4.66908793
8sulfur amino acid catabolic process (GO:0000098)4.32206502
9regulation of cardioblast differentiation (GO:0051890)3.91741018
10benzene-containing compound metabolic process (GO:0042537)3.87800958
11epoxygenase P450 pathway (GO:0019373)3.79125598
12regulation of cholesterol biosynthetic process (GO:0045540)3.69364435
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.57991951
14L-phenylalanine catabolic process (GO:0006559)3.57991951
15L-phenylalanine metabolic process (GO:0006558)3.41243532
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.41243532
17paraxial mesoderm development (GO:0048339)3.40020202
18regulation of transforming growth factor beta2 production (GO:0032909)3.36374077
19hormone catabolic process (GO:0042447)3.35760171
20gap junction assembly (GO:0016264)3.34809275
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.34770295
22embryonic foregut morphogenesis (GO:0048617)3.34490068
23bile acid biosynthetic process (GO:0006699)3.29812568
24tryptophan metabolic process (GO:0006568)3.28126278
25cysteine metabolic process (GO:0006534)3.27767060
26glutathione metabolic process (GO:0006749)3.25237356
27embryonic retina morphogenesis in camera-type eye (GO:0060059)3.24519234
28serine family amino acid catabolic process (GO:0009071)3.24354273
29regulation of bile acid biosynthetic process (GO:0070857)3.23009068
30midgut development (GO:0007494)3.21344488
31tryptophan catabolic process (GO:0006569)3.18526034
32indole-containing compound catabolic process (GO:0042436)3.18526034
33indolalkylamine catabolic process (GO:0046218)3.18526034
34metanephric mesenchyme development (GO:0072075)3.18098883
35aromatic amino acid family catabolic process (GO:0009074)3.17996753
36L-ascorbic acid metabolic process (GO:0019852)3.16770031
37renal absorption (GO:0070293)3.12230110
38nuclear pore complex assembly (GO:0051292)3.11981772
39amino-acid betaine metabolic process (GO:0006577)3.11923094
40homocysteine metabolic process (GO:0050667)3.07384808
41negative regulation of fatty acid transport (GO:2000192)3.06370249
42regulation of cholesterol metabolic process (GO:0090181)3.06036595
43outer ear morphogenesis (GO:0042473)3.01997522
44kidney mesenchyme development (GO:0072074)3.00394188
45intestinal absorption (GO:0050892)2.99097171
46gastrulation with mouth forming second (GO:0001702)2.98105476
47carnitine metabolic process (GO:0009437)2.96809762
48plasma lipoprotein particle assembly (GO:0034377)2.95299500
49regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.92981483
50G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.92920439
513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.92429831
52purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.92429831
53pre-miRNA processing (GO:0031054)2.91581606
54flavonoid metabolic process (GO:0009812)2.91143229
55lysine catabolic process (GO:0006554)2.89442898
56lysine metabolic process (GO:0006553)2.89442898
57kynurenine metabolic process (GO:0070189)2.88961926
58positive regulation of catenin import into nucleus (GO:0035413)2.86136641
59regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.85090572
60glutathione derivative biosynthetic process (GO:1901687)2.83937848
61glutathione derivative metabolic process (GO:1901685)2.83937848
62planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83346396
63cellular modified amino acid catabolic process (GO:0042219)2.83233064
64dorsal/ventral axis specification (GO:0009950)2.82675950
65high-density lipoprotein particle remodeling (GO:0034375)2.82652062
66establishment of apical/basal cell polarity (GO:0035089)2.82316602
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.81441826
68epithelial cell-cell adhesion (GO:0090136)2.79505521
69bile acid metabolic process (GO:0008206)2.78476047
70urea metabolic process (GO:0019627)2.77039154
71urea cycle (GO:0000050)2.77039154
72nuclear pore organization (GO:0006999)2.76894354
73very-low-density lipoprotein particle assembly (GO:0034379)2.76377291
74retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74145965
75positive regulation of fatty acid beta-oxidation (GO:0032000)2.73203006
76anterior/posterior axis specification, embryo (GO:0008595)2.72827463
77reverse cholesterol transport (GO:0043691)2.72825885
78mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.72388775
79aldehyde catabolic process (GO:0046185)2.69321645
80negative regulation of fibrinolysis (GO:0051918)2.68435382
81notochord development (GO:0030903)2.68031478
82protein-lipid complex assembly (GO:0065005)2.67903660
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66207404
84serine family amino acid metabolic process (GO:0009069)2.65612352
85negative regulation of keratinocyte proliferation (GO:0010839)2.64700365
86retinal rod cell development (GO:0046548)2.63966190
87drug transmembrane transport (GO:0006855)2.63551255
88establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.63502256
89branching involved in salivary gland morphogenesis (GO:0060445)2.63231322
90regulation of posttranscriptional gene silencing (GO:0060147)2.63071650
91regulation of gene silencing by miRNA (GO:0060964)2.63071650
92regulation of gene silencing by RNA (GO:0060966)2.63071650
93negative regulation of fatty acid biosynthetic process (GO:0045717)2.62740047
94galactose metabolic process (GO:0006012)2.61038916
95convergent extension (GO:0060026)2.60794042
96Notch signaling involved in heart development (GO:0061314)2.59437693
97negative regulation of lipase activity (GO:0060192)2.58617426
98regulation of protein activation cascade (GO:2000257)2.58095411
99negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.57963481
100negative regulation of hormone metabolic process (GO:0032351)2.57354397
101omega-hydroxylase P450 pathway (GO:0097267)2.57240489
102amine catabolic process (GO:0009310)2.56831905
103cellular biogenic amine catabolic process (GO:0042402)2.56831905
104regulation of cholesterol esterification (GO:0010872)2.53353537
105polyol transport (GO:0015791)2.52748051
106polarized epithelial cell differentiation (GO:0030859)2.51989170
107drug catabolic process (GO:0042737)2.51602209
108morphogenesis of an epithelial sheet (GO:0002011)2.51511585
109regulation of skeletal muscle contraction (GO:0014819)2.51420700
110cellular amino acid catabolic process (GO:0009063)2.51244206
111regulation of fibrinolysis (GO:0051917)2.51221475
112fatty acid beta-oxidation (GO:0006635)2.50932940
113monocarboxylic acid catabolic process (GO:0072329)2.50586368
114hemidesmosome assembly (GO:0031581)2.49995892
115positive regulation of male gonad development (GO:2000020)2.49744547
116calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.49309390
117regulation of cell fate specification (GO:0042659)2.49171275
118indolalkylamine metabolic process (GO:0006586)2.48963528
119phospholipid homeostasis (GO:0055091)2.48504252
120neural crest cell development (GO:0014032)2.47757604
1212-oxoglutarate metabolic process (GO:0006103)2.47756973
122mammary gland development (GO:0030879)2.46036994
123regulation of complement activation (GO:0030449)2.45867281
124desmosome organization (GO:0002934)2.44819883
125hippo signaling (GO:0035329)2.44809851
126intestinal cholesterol absorption (GO:0030299)2.43390392
127carboxylic acid catabolic process (GO:0046395)2.43235380
128organic acid catabolic process (GO:0016054)2.43235380
129tyrosine metabolic process (GO:0006570)2.42188996
130peptidyl-glutamic acid carboxylation (GO:0017187)2.41756237
131protein carboxylation (GO:0018214)2.41756237
132removal of superoxide radicals (GO:0019430)2.41196728
133cellular response to superoxide (GO:0071451)2.41196728
134cellular response to oxygen radical (GO:0071450)2.41196728
135branched-chain amino acid catabolic process (GO:0009083)2.40864919
136negative regulation of chondrocyte differentiation (GO:0032331)2.39779663
137alpha-amino acid catabolic process (GO:1901606)2.39414087
138nitrogen cycle metabolic process (GO:0071941)2.39105249
139lung-associated mesenchyme development (GO:0060484)2.38755939
140excretion (GO:0007588)2.38115144
141regulation of cholesterol homeostasis (GO:2000188)2.37964507
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.37921290
143xenobiotic metabolic process (GO:0006805)2.37869142
144regulation of non-canonical Wnt signaling pathway (GO:2000050)2.37412161
145biotin metabolic process (GO:0006768)2.35572383
146positive regulation of SMAD protein import into nucleus (GO:0060391)2.32222089
147regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.31898892
148atrioventricular valve morphogenesis (GO:0003181)2.31661926
149cardiac myofibril assembly (GO:0055003)2.30364034
150establishment of monopolar cell polarity (GO:0061162)2.29923385
151establishment or maintenance of monopolar cell polarity (GO:0061339)2.29923385
152COPII vesicle coating (GO:0048208)2.26625571
153regulation of steroid hormone biosynthetic process (GO:0090030)2.23836691
154negative regulation of cell fate specification (GO:0009996)2.23340884
155doxorubicin metabolic process (GO:0044598)2.22978768
156daunorubicin metabolic process (GO:0044597)2.22978768
157polyketide metabolic process (GO:0030638)2.22978768
158negative regulation of hormone biosynthetic process (GO:0032353)2.22675452
159mesenchymal cell proliferation (GO:0010463)2.22257704
160apical protein localization (GO:0045176)2.22101505
161plasma lipoprotein particle remodeling (GO:0034369)2.19988378
162protein-lipid complex remodeling (GO:0034368)2.19988378
163macromolecular complex remodeling (GO:0034367)2.19988378
164ectodermal placode formation (GO:0060788)2.19187988
165cell migration involved in gastrulation (GO:0042074)2.18636006
166cholesterol efflux (GO:0033344)2.18394358
167regulation of catenin import into nucleus (GO:0035412)2.17272322
168alpha-linolenic acid metabolic process (GO:0036109)2.17134970
169atrial septum morphogenesis (GO:0060413)2.16862047
170cell surface receptor signaling pathway involved in heart development (GO:0061311)2.15996680
171positive regulation of cardiac muscle cell proliferation (GO:0060045)2.15744064
172positive regulation of hormone biosynthetic process (GO:0046886)2.15676916
173chondrocyte proliferation (GO:0035988)2.15511209
174establishment or maintenance of bipolar cell polarity (GO:0061245)2.11452031
175establishment or maintenance of apical/basal cell polarity (GO:0035088)2.11452031
176phospholipid efflux (GO:0033700)2.10874796
177aminoglycoside antibiotic metabolic process (GO:0030647)2.09486957
178ethanol oxidation (GO:0006069)2.09413860
179heterochromatin organization (GO:0070828)2.08917688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.80290982
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.33891170
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.22144111
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.20940879
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.91810495
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.87911831
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.81346543
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.77307918
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.70361180
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.56491177
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43879361
12CLOCK_20551151_ChIP-Seq_293T_Human2.39969705
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.36538633
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.26292852
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23377339
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18120125
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06603024
18E2F7_22180533_ChIP-Seq_HELA_Human2.05317188
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02503865
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.96139716
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.95237559
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.95237559
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.95237559
24ZNF263_19887448_ChIP-Seq_K562_Human1.90511444
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87751431
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87495519
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77105623
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76641958
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76537621
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.75767450
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.75014954
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74376635
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71708624
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71596070
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.70962170
36AR_21909140_ChIP-Seq_LNCAP_Human1.70593741
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67206563
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64376794
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63459744
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62722813
41* FOXA2_19822575_ChIP-Seq_HepG2_Human1.57376960
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55228096
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55058909
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53298615
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53298615
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45359526
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43261626
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.42981898
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42276134
50* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36309320
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34203070
52TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33821102
53* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33766575
54GATA4_25053715_ChIP-Seq_YYC3_Human1.30348980
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.29115634
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28513398
57SMAD3_21741376_ChIP-Seq_HESCs_Human1.28101789
58* SOX2_20726797_ChIP-Seq_SW620_Human1.26962535
59* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26805562
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26431947
61* AHR_22903824_ChIP-Seq_MCF-7_Human1.25730893
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25236002
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.24976173
64CJUN_26792858_Chip-Seq_BT549_Human1.24531085
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22866931
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22197123
67TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22036522
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21987118
69FUS_26573619_Chip-Seq_HEK293_Human1.21884106
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21402776
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18778940
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16751431
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.16631649
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16051932
75RXR_22108803_ChIP-Seq_LS180_Human1.15387856
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15207964
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15146491
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.14561126
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.13844966
80* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13772910
81* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13313105
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13203206
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12792639
84BCAT_22108803_ChIP-Seq_LS180_Human1.12439608
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11918723
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11169214
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11030483
88TP53_18474530_ChIP-ChIP_U2OS_Human1.10759636
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10313460
90* ARNT_22903824_ChIP-Seq_MCF-7_Human1.10218330
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09238367
92* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08598144
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.07410985
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07181787
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07181787
96* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05192390
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04399499
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03882997
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.03872156
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03425105
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01690800
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.00531635
103SOX17_20123909_ChIP-Seq_XEN_Mouse1.00379720
104NANOG_16518401_ChIP-PET_MESCs_Mouse0.99915559
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.99377999
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99206009
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.98868465
108POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98841126
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98809856
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98664595
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97013407
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.96527383
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96079002
114* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96005068
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.95113664
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94720602
117GATA3_24758297_ChIP-Seq_MCF-7_Human0.94277146
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94243025
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93787131
120GBX2_23144817_ChIP-Seq_PC3_Human0.93365618
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92677107
122CDX2_22108803_ChIP-Seq_LS180_Human0.92526556
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90944251
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90617511
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90595095
126* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90516771
127TP53_16413492_ChIP-PET_HCT116_Human0.89079532
128NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89053842
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88864657
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87681801
131* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87256841
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87242955
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86282045
134GATA6_25053715_ChIP-Seq_YYC3_Human0.86098328
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86026133
136* HNF4A_19822575_ChIP-Seq_HepG2_Human0.86013946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.88763221
2MP0005360_urolithiasis3.59913073
3MP0008789_abnormal_olfactory_epithelium3.43535013
4MP0005085_abnormal_gallbladder_physiolo3.26159200
5MP0005499_abnormal_olfactory_system3.15683161
6MP0005394_taste/olfaction_phenotype3.15683161
7MP0010030_abnormal_orbit_morphology3.07551663
8MP0009053_abnormal_anal_canal3.02998146
9MP0003806_abnormal_nucleotide_metabolis2.69295822
10MP0008875_abnormal_xenobiotic_pharmacok2.68483387
11MP0003878_abnormal_ear_physiology2.52223386
12MP0005377_hearing/vestibular/ear_phenot2.52223386
13MP0005365_abnormal_bile_salt2.45135692
14MP0003195_calcinosis2.30581508
15MP0000566_synostosis2.25328356
16MP0003941_abnormal_skin_development2.20763412
17MP0001984_abnormal_olfaction2.13480937
18MP0003705_abnormal_hypodermis_morpholog2.09891437
19MP0002009_preneoplasia2.04922150
20MP0009384_cardiac_valve_regurgitation1.96354525
21MP0003252_abnormal_bile_duct1.89600413
22MP0002233_abnormal_nose_morphology1.84169339
23MP0001299_abnormal_eye_distance/1.79569032
24MP0010234_abnormal_vibrissa_follicle1.72996363
25MP0001293_anophthalmia1.68943219
26MP0005248_abnormal_Harderian_gland1.64248315
27MP0003186_abnormal_redox_activity1.59444093
28MP0003567_abnormal_fetal_cardiomyocyte1.57830808
29MP0002249_abnormal_larynx_morphology1.54950572
30MP0009250_abnormal_appendicular_skeleto1.54429842
31MP0004019_abnormal_vitamin_homeostasis1.53647342
32MP0009672_abnormal_birth_weight1.53201662
33MP0000049_abnormal_middle_ear1.49762873
34MP0005275_abnormal_skin_tensile1.47838111
35MP0000762_abnormal_tongue_morphology1.47703563
36MP0003942_abnormal_urinary_system1.46720819
37MP0010329_abnormal_lipoprotein_level1.46007445
38MP0005257_abnormal_intraocular_pressure1.45894440
39MP0008438_abnormal_cutaneous_collagen1.45608655
40MP0000534_abnormal_ureter_morphology1.44760932
41MP0003868_abnormal_feces_composition1.42519741
42MP0003566_abnormal_cell_adhesion1.40840411
43* MP0005332_abnormal_amino_acid1.37574573
44MP0000678_abnormal_parathyroid_gland1.31325594
45MP0005408_hypopigmentation1.30746396
46MP0003937_abnormal_limbs/digits/tail_de1.30666577
47MP0005503_abnormal_tendon_morphology1.28846338
48MP0002877_abnormal_melanocyte_morpholog1.28050664
49MP0002084_abnormal_developmental_patter1.27606628
50MP0003755_abnormal_palate_morphology1.23422818
51MP0003283_abnormal_digestive_organ1.22597699
52MP0003122_maternal_imprinting1.21494898
53MP0002098_abnormal_vibrissa_morphology1.20621739
54MP0001177_atelectasis1.17036522
55MP0004272_abnormal_basement_membrane1.16867416
56MP0002254_reproductive_system_inflammat1.15213955
57* MP0003984_embryonic_growth_retardation1.13717104
58* MP0002088_abnormal_embryonic_growth/wei1.11484348
59MP0010368_abnormal_lymphatic_system1.09740358
60* MP0005380_embryogenesis_phenotype1.08873722
61* MP0001672_abnormal_embryogenesis/_devel1.08873722
62MP0004957_abnormal_blastocyst_morpholog1.08025280
63MP0001666_abnormal_nutrient_absorption1.07127864
64MP0002938_white_spotting1.06718514
65MP0003123_paternal_imprinting1.05882694
66MP0005367_renal/urinary_system_phenotyp1.05618639
67MP0000516_abnormal_urinary_system1.05618639
68MP0002060_abnormal_skin_morphology1.05322061
69MP0001661_extended_life_span1.05021071
70MP0004264_abnormal_extraembryonic_tissu1.04777489
71MP0001730_embryonic_growth_arrest1.04664281
72MP0005076_abnormal_cell_differentiation1.03789900
73MP0002085_abnormal_embryonic_tissue1.03589281
74MP0003115_abnormal_respiratory_system1.03477439
75MP0001346_abnormal_lacrimal_gland1.02828063
76MP0004043_abnormal_pH_regulation1.02322447
77MP0005409_darkened_coat_color1.01542344
78* MP0005197_abnormal_uvea_morphology1.01281301
79MP0009703_decreased_birth_body1.01021359
80MP0005171_absent_coat_pigmentation1.00901113
81MP0002876_abnormal_thyroid_physiology0.99497100
82MP0002086_abnormal_extraembryonic_tissu0.98384380
83MP0004885_abnormal_endolymph0.98155524
84MP0001485_abnormal_pinna_reflex0.96561853
85MP0004084_abnormal_cardiac_muscle0.95861778
86MP0002796_impaired_skin_barrier0.95018050
87MP0005623_abnormal_meninges_morphology0.94778262
88MP0002089_abnormal_postnatal_growth/wei0.94646305
89MP0001286_abnormal_eye_development0.93916555
90MP0003279_aneurysm0.93729572
91MP0003890_abnormal_embryonic-extraembry0.93584579
92MP0000537_abnormal_urethra_morphology0.92356266
93MP0001915_intracranial_hemorrhage0.91737411
94MP0000613_abnormal_salivary_gland0.91427255
95MP0002282_abnormal_trachea_morphology0.90579168
96MP0010630_abnormal_cardiac_muscle0.90170122
97MP0002111_abnormal_tail_morphology0.89968998
98MP0005508_abnormal_skeleton_morphology0.88170780
99MP0003315_abnormal_perineum_morphology0.87758210
100MP0008932_abnormal_embryonic_tissue0.87587612
101MP0002653_abnormal_ependyma_morphology0.87484147
102MP0005391_vision/eye_phenotype0.87465673
103MP0006292_abnormal_olfactory_placode0.86759293
104MP0003385_abnormal_body_wall0.86660374
105MP0001697_abnormal_embryo_size0.85851208
106MP0000432_abnormal_head_morphology0.85116855
107MP0004858_abnormal_nervous_system0.84317241
108MP0000163_abnormal_cartilage_morphology0.84212451
109MP0003119_abnormal_digestive_system0.83965564
110MP0009643_abnormal_urine_homeostasis0.83309470
111MP0010352_gastrointestinal_tract_polyps0.83183089
112* MP0002697_abnormal_eye_size0.83077073
113MP0000538_abnormal_urinary_bladder0.81555224
114MP0002896_abnormal_bone_mineralization0.81382514
115MP0009697_abnormal_copulation0.80591932
116MP0003950_abnormal_plasma_membrane0.80412948
117MP0005220_abnormal_exocrine_pancreas0.79121305
118MP0002116_abnormal_craniofacial_bone0.78884145
119MP0001849_ear_inflammation0.77970447
120MP0000467_abnormal_esophagus_morphology0.77086181
121MP0000647_abnormal_sebaceous_gland0.76655096
122* MP0004197_abnormal_fetal_growth/weight/0.74953050
123MP0002277_abnormal_respiratory_mucosa0.74452068
124MP0006138_congestive_heart_failure0.73703085
125MP0003861_abnormal_nervous_system0.73681330
126MP0003935_abnormal_craniofacial_develop0.72511163
127MP0000462_abnormal_digestive_system0.72197103
128MP0002168_other_aberrant_phenotype0.70571441
129MP0004215_abnormal_myocardial_fiber0.69821624
130MP0000428_abnormal_craniofacial_morphol0.69676384
131MP0002092_abnormal_eye_morphology0.69601882
132MP0005319_abnormal_enzyme/_coenzyme0.69301407
133MP0002115_abnormal_skeleton_extremities0.69272239
134MP0005023_abnormal_wound_healing0.69211098
135MP0004134_abnormal_chest_morphology0.68887106
136MP0010678_abnormal_skin_adnexa0.68784082
137MP0000778_abnormal_nervous_system0.68727441
138MP0005187_abnormal_penis_morphology0.67611198
139MP0000579_abnormal_nail_morphology0.67582497
140MP0009780_abnormal_chondrocyte_physiolo0.67144622
141MP0003936_abnormal_reproductive_system0.66435028
142MP0002132_abnormal_respiratory_system0.66366162
143MP0005395_other_phenotype0.65990864
144MP0001270_distended_abdomen0.65906129
145MP0002109_abnormal_limb_morphology0.64994925

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)3.83763403
2Intrahepatic cholestasis (HP:0001406)3.44776505
3Renal tubular acidosis (HP:0001947)3.34935882
4Right ventricular cardiomyopathy (HP:0011663)3.21673187
5Abnormality of cochlea (HP:0000375)3.10765175
6Hyperglycinemia (HP:0002154)2.97326186
7Abnormality of glutamine family amino acid metabolism (HP:0010902)2.88131724
8Abnormality of glycine metabolism (HP:0010895)2.82820733
9Abnormality of serine family amino acid metabolism (HP:0010894)2.82820733
10Chorioretinal atrophy (HP:0000533)2.81896952
11Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80639533
12Lip pit (HP:0100267)2.75447046
13Epidermoid cyst (HP:0200040)2.61821214
14Ileus (HP:0002595)2.61805348
15Hypobetalipoproteinemia (HP:0003563)2.59274816
16Periauricular skin pits (HP:0100277)2.58682471
17Preauricular pit (HP:0004467)2.58682471
18Flat acetabular roof (HP:0003180)2.57183450
19Hepatocellular carcinoma (HP:0001402)2.52247907
20Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.50940763
21Partial duplication of thumb phalanx (HP:0009944)2.49521947
22Coronal craniosynostosis (HP:0004440)2.48241167
23Aplasia involving bones of the extremities (HP:0009825)2.47258060
24Aplasia involving bones of the upper limbs (HP:0009823)2.47258060
25Aplasia of the phalanges of the hand (HP:0009802)2.47258060
26Hepatoblastoma (HP:0002884)2.41283780
27Papillary thyroid carcinoma (HP:0002895)2.40356484
28Follicular hyperkeratosis (HP:0007502)2.37051972
29Abnormality of the nasal septum (HP:0000419)2.35770243
30Lymphangioma (HP:0100764)2.35277755
31Vertebral clefting (HP:0008428)2.33888774
32Prolonged partial thromboplastin time (HP:0003645)2.33219953
33Hyperactive renin-angiotensin system (HP:0000841)2.29198693
34Fat malabsorption (HP:0002630)2.27662045
35Abnormality of chloride homeostasis (HP:0011422)2.27651351
36Xanthomatosis (HP:0000991)2.24890127
37Conjugated hyperbilirubinemia (HP:0002908)2.24829513
38Short hallux (HP:0010109)2.21706860
39Abnormality of carpal bone ossification (HP:0006257)2.20928666
40Choanal stenosis (HP:0000452)2.19393905
41Myelomeningocele (HP:0002475)2.19325469
42Hypolipoproteinemia (HP:0010981)2.17859586
43Preaxial foot polydactyly (HP:0001841)2.17522018
44Enlarged kidneys (HP:0000105)2.16387880
45Hypoplasia of the uterus (HP:0000013)2.15560426
46Septo-optic dysplasia (HP:0100842)2.15387312
47Partial duplication of the phalanx of hand (HP:0009999)2.15364511
48Deep venous thrombosis (HP:0002625)2.13236809
49Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.13001754
50Alopecia of scalp (HP:0002293)2.12419133
51Absent eyebrow (HP:0002223)2.12358076
52Neonatal short-limb short stature (HP:0008921)2.11593484
53Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.09996596
54Abnormality of the distal phalanges of the toes (HP:0010182)2.09638988
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.07412133
56Abnormality of the phalanges of the 5th finger (HP:0004213)2.05235542
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04567349
58Abnormality of the middle phalanges of the toes (HP:0010183)2.04003363
59Hydroxyprolinuria (HP:0003080)2.03342967
60Abnormality of proline metabolism (HP:0010907)2.03342967
61Subcapsular cataract (HP:0000523)2.03267080
62Potter facies (HP:0002009)2.02774475
63Facial shape deformation (HP:0011334)2.02774475
64Gout (HP:0001997)2.02214982
65Neoplasm of the adrenal gland (HP:0100631)2.02157237
66Hypoplastic scapulae (HP:0000882)2.02143804
67Aplasia/Hypoplasia of the scapulae (HP:0006713)2.02143804
68Protrusio acetabuli (HP:0003179)2.01286384
69Arterial tortuosity (HP:0005116)1.99690042
70Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99180624
71Skin pits (HP:0100276)1.98420936
72Hyperammonemia (HP:0001987)1.97744521
73Proximal tubulopathy (HP:0000114)1.96072732
74Hypoalphalipoproteinemia (HP:0003233)1.95812145
75Osteomalacia (HP:0002749)1.95779067
76Bifid tongue (HP:0010297)1.95721133
77Abnormal ossification of hand bones (HP:0005921)1.94856809
78Aplasia/Hypoplasia of the hallux (HP:0008362)1.93929322
79Anal stenosis (HP:0002025)1.93829849
80Bronchomalacia (HP:0002780)1.93612756
81Abnormality of sulfur amino acid metabolism (HP:0004339)1.93584540
82Alacrima (HP:0000522)1.93151539
83Turricephaly (HP:0000262)1.92477807
84Vaginal fistula (HP:0004320)1.92020978
85Rectal prolapse (HP:0002035)1.91013914
86Abnormal biliary tract morphology (HP:0012440)1.90764282
87Renal tubular dysfunction (HP:0000124)1.90726750
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.90668291
89Abnormal cartilage morphology (HP:0002763)1.90652703
90Abnormal hand bone ossification (HP:0010660)1.89999171
91Broad metatarsal (HP:0001783)1.88874247
92Cutaneous finger syndactyly (HP:0010554)1.88219155
93Abnormal tarsal ossification (HP:0008369)1.87664044
94Duplication of thumb phalanx (HP:0009942)1.87332291
95Acanthocytosis (HP:0001927)1.87060431
96Premature rupture of membranes (HP:0001788)1.87034803
97Missing ribs (HP:0000921)1.86894272
98Vitreoretinal degeneration (HP:0000655)1.86686000
99Alveolar cell carcinoma (HP:0006519)1.86483323
100Complement deficiency (HP:0004431)1.85751828
101Renal salt wasting (HP:0000127)1.85672632
102Thyroid carcinoma (HP:0002890)1.85663607
103Cardiovascular calcification (HP:0011915)1.84737339
104Ventricular tachycardia (HP:0004756)1.84468114
105Neoplasm of the liver (HP:0002896)1.82379157
106Abnormality of the lacrimal duct (HP:0011481)1.81414313
107Arnold-Chiari malformation (HP:0002308)1.81380782
108Bifid scrotum (HP:0000048)1.80012709
109Limited hip movement (HP:0008800)1.79509387
110Onycholysis (HP:0001806)1.78714412
111Abnormal foot bone ossification (HP:0010675)1.78708762
112Anophthalmia (HP:0000528)1.78281847
113Vascular calcification (HP:0004934)1.77707647
114Shallow orbits (HP:0000586)1.76951684
115Cutaneous syndactyly (HP:0012725)1.76788247
116Pterygium (HP:0001059)1.76783294
117Asymmetry of the thorax (HP:0001555)1.76561482
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76445780
119Decreased lacrimation (HP:0000633)1.76426770
120Carpal synostosis (HP:0009702)1.76406556
121Abnormality of the proximal phalanges of the hand (HP:0009834)1.75323837
122Abnormal pancreas size (HP:0012094)1.73903374
123Absent eyelashes (HP:0000561)1.72618613
124Hypokalemic alkalosis (HP:0001949)1.72254843
125Wide nose (HP:0000445)1.72017026
126Abnormality of purine metabolism (HP:0004352)1.72015845
127Morphological abnormality of the inner ear (HP:0011390)1.71494617
128Neoplasm of the tracheobronchial system (HP:0100552)1.71140042
129Hyperuricemia (HP:0002149)1.71044581
130Increased purine levels (HP:0004368)1.71044581
131High anterior hairline (HP:0009890)1.70730756
132Mixed hearing impairment (HP:0000410)1.69848475
133Hyperaldosteronism (HP:0000859)1.69284172
134Broad palm (HP:0001169)1.69246219
135Synostosis involving bones of the lower limbs (HP:0009138)1.68565847
136Synostosis involving bones of the feet (HP:0009140)1.68565847
137Abnormality of the common coagulation pathway (HP:0010990)1.68418894
138Synostosis of carpal bones (HP:0005048)1.67880044
139Pseudobulbar signs (HP:0002200)1.67282675
140Hypoplastic labia majora (HP:0000059)1.67087622
141Midline defect of the nose (HP:0004122)1.66811003
142Steatorrhea (HP:0002570)1.66534169
143Short middle phalanx of the 5th finger (HP:0004220)1.65949612
144Embryonal renal neoplasm (HP:0011794)1.65748095
145Tarsal synostosis (HP:0008368)1.65328725
146Short humerus (HP:0005792)1.65030104
147Rickets (HP:0002748)1.64479074
148Transposition of the great arteries (HP:0001669)1.64460278
149Abnormal connection of the cardiac segments (HP:0011545)1.64460278
150Abnormal ventriculo-arterial connection (HP:0011563)1.64460278
151Pigmentary retinal degeneration (HP:0001146)1.63611853
152Ketoacidosis (HP:0001993)1.63460483
153Atrophic scars (HP:0001075)1.63200000
154Abnormal vertebral ossification (HP:0100569)1.63115691
155Omphalocele (HP:0001539)1.62746615
156Vascular tortuosity (HP:0004948)1.62621732
157Hypercholesterolemia (HP:0003124)1.62383622
158Malnutrition (HP:0004395)1.62331280
159Maternal diabetes (HP:0009800)1.61940551
160Hemorrhage of the eye (HP:0011885)1.61849865
161Advanced eruption of teeth (HP:0006288)1.61071055
162Abnormality of the nasolacrimal system (HP:0000614)1.60743466
163Hypoglycemic seizures (HP:0002173)1.58184467
164Abnormality of the lumbar spine (HP:0100712)1.56681704
165Tracheal stenosis (HP:0002777)1.56523883
166Abnormality of the ischium (HP:0003174)1.54650129
167Short middle phalanx of finger (HP:0005819)1.53982482
168Nephroblastoma (Wilms tumor) (HP:0002667)1.53928224
169Vertebral arch anomaly (HP:0008438)1.51647448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.85936733
2LMTK24.50890497
3STK38L3.39596282
4ZAK3.09034742
5LATS12.94287527
6ERBB32.89699244
7AKT32.73602479
8MAP3K102.28876615
9MKNK22.25294154
10BCKDK2.21699318
11SGK22.08987628
12EPHA21.98682001
13MKNK11.92788054
14FGFR41.88959642
15MAP3K31.81953722
16WNK31.68813018
17NEK11.67554216
18DDR21.61867577
19FER1.60533092
20SGK31.57411781
21NUAK11.56746286
22SGK2231.54710989
23SGK4941.54710989
24BRSK21.50241787
25FLT31.47644958
26ICK1.45472193
27MST41.44929326
28ERBB41.42478846
29PBK1.39489473
30SIK11.39311781
31MAP3K21.37629352
32PIK3CA1.36203415
33TRPM71.33177200
34EEF2K1.30321886
35WNK41.27748091
36EPHA41.26422189
37EPHB21.20445718
38BRD41.20197602
39OXSR11.19638112
40BMPR21.18604338
41DMPK1.18414525
42PRPF4B1.17759316
43PLK41.17137519
44TYRO31.16574819
45PRKG21.13794379
46STK31.10743140
47PLK31.08542610
48PAK41.04925603
49STK391.04585154
50ACVR1B1.02780236
51MST1R1.02304580
52NEK61.02135966
53CDC71.01647423
54PTK21.00747445
55WEE10.99779497
56RPS6KB20.99583819
57LATS20.97398418
58STK240.96660574
59SRPK10.96340258
60FGFR30.96109611
61PINK10.94344563
62NTRK10.93847590
63CAMK1G0.93828869
64PDK20.92026749
65TSSK60.91749108
66OBSCN0.91438794
67PDGFRB0.88742047
68RIPK10.88689501
69BCR0.88141437
70TNIK0.86169782
71CDK60.84368409
72PKN20.82942974
73NEK20.81402467
74MTOR0.80916910
75CAMK1D0.80631904
76BMX0.74616683
77STK40.74125492
78ROCK10.73418557
79YES10.73086530
80PTK60.70093823
81PLK20.68095272
82FGFR10.67757058
83PRKCI0.67736126
84TTN0.67397171
85TTK0.67337501
86CASK0.65874728
87PDGFRA0.65770662
88MET0.65564284
89ERBB20.65196453
90FGFR20.64304768
91PNCK0.63821822
92PDK30.63616838
93PDK40.63616838
94MAP2K10.63323724
95RET0.63308216
96PAK30.62789186
97CDK70.60164721
98NLK0.59725505
99CDK120.58629275
100KSR10.58173944
101PRKAA10.56673794
102MAP3K40.56346458
103CSNK1E0.54764317
104DYRK30.54597972
105RPS6KB10.53813358
106TESK10.53596963
107NEK90.51342392
108MAP3K60.51148714
109NME10.50447797
110PAK20.49321062
111GSK3A0.49216186
112PRKCE0.48508494
113SCYL20.47912620
114CHUK0.47056874
115MYLK0.45634986
116BRSK10.45589741
117TAF10.44809798
118PLK10.44314973
119MELK0.44099101
120CHEK20.40739165
121MAPK70.39364759
122CSNK1G10.38667076
123BUB10.38503844
124AURKA0.38355897
125TRIB30.37442192
126SGK10.37329058
127PRKAA20.35005006
128LIMK10.34805352
129AURKB0.33715186
130DYRK1B0.31363536
131TAOK20.31304255
132AKT20.30922530
133MAPK150.30797266
134WNK10.30509263
135ATM0.30177031
136DYRK1A0.30067348
137SIK30.27762354
138CSNK1A10.26366879
139RPS6KL10.25684002
140RPS6KC10.25684002
141CDC42BPA0.25310432
142EIF2AK20.24555869
143PRKD30.24061346

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.06713561
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.79967680
3Sulfur metabolism_Homo sapiens_hsa009203.53630271
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.75800692
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.72290097
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.69599251
7Chemical carcinogenesis_Homo sapiens_hsa052042.50070011
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.40206833
9Butanoate metabolism_Homo sapiens_hsa006502.10662366
10Fatty acid degradation_Homo sapiens_hsa000712.06549393
11Starch and sucrose metabolism_Homo sapiens_hsa005002.03867505
12Peroxisome_Homo sapiens_hsa041462.00475161
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.99248808
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98147020
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92550987
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86640921
17Propanoate metabolism_Homo sapiens_hsa006401.79211767
18Glutathione metabolism_Homo sapiens_hsa004801.77471953
19Retinol metabolism_Homo sapiens_hsa008301.76206645
20Tryptophan metabolism_Homo sapiens_hsa003801.75872085
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74839531
22Selenocompound metabolism_Homo sapiens_hsa004501.65343830
23Nitrogen metabolism_Homo sapiens_hsa009101.64365187
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62356628
25Fatty acid metabolism_Homo sapiens_hsa012121.60056110
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58991123
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.48778824
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43810488
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41061383
30Sulfur relay system_Homo sapiens_hsa041221.36206045
31Galactose metabolism_Homo sapiens_hsa000521.35738025
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35016603
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34515690
34PPAR signaling pathway_Homo sapiens_hsa033201.33604042
35Arginine biosynthesis_Homo sapiens_hsa002201.30113151
36beta-Alanine metabolism_Homo sapiens_hsa004101.27268813
37Pyruvate metabolism_Homo sapiens_hsa006201.24384742
38Steroid biosynthesis_Homo sapiens_hsa001001.23517819
39Bile secretion_Homo sapiens_hsa049761.22660342
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21961526
41Caffeine metabolism_Homo sapiens_hsa002321.19459849
42Fatty acid biosynthesis_Homo sapiens_hsa000611.18523894
43One carbon pool by folate_Homo sapiens_hsa006701.15835034
44Phenylalanine metabolism_Homo sapiens_hsa003601.14815704
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13717481
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12819107
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10912369
48Mineral absorption_Homo sapiens_hsa049781.09345448
49Vitamin digestion and absorption_Homo sapiens_hsa049771.09136942
50Carbon metabolism_Homo sapiens_hsa012001.03500641
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.02119761
52Complement and coagulation cascades_Homo sapiens_hsa046101.01125819
53Histidine metabolism_Homo sapiens_hsa003401.00843951
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99825729
55Tyrosine metabolism_Homo sapiens_hsa003500.94407980
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93479110
57Vitamin B6 metabolism_Homo sapiens_hsa007500.93430271
58Biosynthesis of amino acids_Homo sapiens_hsa012300.86471399
59Adherens junction_Homo sapiens_hsa045200.84659275
60Fat digestion and absorption_Homo sapiens_hsa049750.83691121
61Arginine and proline metabolism_Homo sapiens_hsa003300.82967259
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82534463
63ABC transporters_Homo sapiens_hsa020100.82295945
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78688395
65Basal cell carcinoma_Homo sapiens_hsa052170.77527111
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77493543
67Folate biosynthesis_Homo sapiens_hsa007900.77204049
68Hippo signaling pathway_Homo sapiens_hsa043900.73356007
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72841576
70Protein digestion and absorption_Homo sapiens_hsa049740.72840408
71Proteoglycans in cancer_Homo sapiens_hsa052050.72647369
72Glycerolipid metabolism_Homo sapiens_hsa005610.70910777
73Tight junction_Homo sapiens_hsa045300.70631388
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68617571
75Small cell lung cancer_Homo sapiens_hsa052220.68224140
76Fructose and mannose metabolism_Homo sapiens_hsa000510.67916946
77Lysine degradation_Homo sapiens_hsa003100.67688667
78Dilated cardiomyopathy_Homo sapiens_hsa054140.66418630
79TGF-beta signaling pathway_Homo sapiens_hsa043500.66337527
80Fatty acid elongation_Homo sapiens_hsa000620.65406162
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64916699
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62893148
83ECM-receptor interaction_Homo sapiens_hsa045120.62716332
84MicroRNAs in cancer_Homo sapiens_hsa052060.60673651
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.58394973
86N-Glycan biosynthesis_Homo sapiens_hsa005100.58376804
87Axon guidance_Homo sapiens_hsa043600.56720395
88Arachidonic acid metabolism_Homo sapiens_hsa005900.55122531
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52838250
90Non-homologous end-joining_Homo sapiens_hsa034500.52025911
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48896987
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46836432
93Cell cycle_Homo sapiens_hsa041100.46475364
94Metabolic pathways_Homo sapiens_hsa011000.45990385
95Pancreatic secretion_Homo sapiens_hsa049720.44659342
96AMPK signaling pathway_Homo sapiens_hsa041520.42437510
97Amoebiasis_Homo sapiens_hsa051460.42388009
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40634441
99Circadian rhythm_Homo sapiens_hsa047100.38179959
100Thyroid cancer_Homo sapiens_hsa052160.34650181
101Melanoma_Homo sapiens_hsa052180.34258651
102Hedgehog signaling pathway_Homo sapiens_hsa043400.33337530
103Endometrial cancer_Homo sapiens_hsa052130.30599537
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29009970
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27939667
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25951832
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.25476420
108Linoleic acid metabolism_Homo sapiens_hsa005910.22623791
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20715612
110Prostate cancer_Homo sapiens_hsa052150.20010276
111Ovarian steroidogenesis_Homo sapiens_hsa049130.19754986
112Glucagon signaling pathway_Homo sapiens_hsa049220.18815716
113Renin-angiotensin system_Homo sapiens_hsa046140.18183562
114Insulin resistance_Homo sapiens_hsa049310.17380526
115Pentose phosphate pathway_Homo sapiens_hsa000300.16915356
116Thyroid hormone synthesis_Homo sapiens_hsa049180.15856406
117Focal adhesion_Homo sapiens_hsa045100.15190519
118Wnt signaling pathway_Homo sapiens_hsa043100.14470185
119Bladder cancer_Homo sapiens_hsa052190.14399773

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