LGR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)9.25184102
2response to growth hormone (GO:0060416)8.18407292
3positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.56263129
4ethanol oxidation (GO:0006069)7.38428352
5regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)6.95426858
6JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)6.93119628
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.79313148
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.79313148
9modulation by symbiont of host immune response (GO:0052553)6.79313148
10positive regulation by symbiont of host defense response (GO:0052509)6.79313148
11modulation by symbiont of host defense response (GO:0052031)6.79313148
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.79313148
13positive regulation of receptor internalization (GO:0002092)6.70927637
14negative regulation of epidermal cell differentiation (GO:0045605)6.58149965
15lung lobe morphogenesis (GO:0060463)6.49658140
16primary alcohol catabolic process (GO:0034310)6.40550856
17negative regulation of complement activation (GO:0045916)6.37891659
18renal absorption (GO:0070293)6.27175025
19hemidesmosome assembly (GO:0031581)6.21905333
20regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.18539070
21macrophage activation involved in immune response (GO:0002281)6.00453987
22regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)5.95388768
23negative regulation of epidermis development (GO:0045683)5.57549818
24detection of molecule of bacterial origin (GO:0032490)5.43057642
25regulation of female gonad development (GO:2000194)5.37982472
26regulation of keratinocyte proliferation (GO:0010837)5.36417682
27negative regulation of protein activation cascade (GO:2000258)5.10057655
28microglial cell activation (GO:0001774)5.04910288
29face development (GO:0060324)5.01876897
30ethanol metabolic process (GO:0006067)4.84223998
31anatomical structure maturation (GO:0071695)4.72258878
32endocardial cushion morphogenesis (GO:0003203)4.62696821
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.53130047
34response to host immune response (GO:0052572)4.53130047
35atrioventricular valve morphogenesis (GO:0003181)4.51772968
36cellular response to interleukin-15 (GO:0071350)4.50065853
37positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)4.49708516
38valine metabolic process (GO:0006573)4.28053880
39regulation of keratinocyte differentiation (GO:0045616)4.26495182
40T-helper 1 type immune response (GO:0042088)4.25616111
41mesenchyme morphogenesis (GO:0072132)4.22832617
42response to host (GO:0075136)4.20143023
43response to host defenses (GO:0052200)4.20143023
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.20143023
45regulation of interleukin-6 biosynthetic process (GO:0045408)4.17424035
46response to interleukin-15 (GO:0070672)4.13327274
47detection of external biotic stimulus (GO:0098581)4.12553753
48notochord development (GO:0030903)4.12108421
49regulation of receptor internalization (GO:0002090)4.10464911
50lymphangiogenesis (GO:0001946)4.09447968
51extracellular regulation of signal transduction (GO:1900115)4.04720883
52extracellular negative regulation of signal transduction (GO:1900116)4.04720883
53negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.02281434
54positive regulation of osteoblast proliferation (GO:0033690)4.01747715
55cardiovascular system development (GO:0072358)3.97434353
56negative regulation of humoral immune response (GO:0002921)3.94992959
57multicellular organismal water homeostasis (GO:0050891)3.90874217
58limb bud formation (GO:0060174)3.84780580
59JAK-STAT cascade (GO:0007259)3.80358461
60detection of biotic stimulus (GO:0009595)3.77188025
61positive regulation of multicellular organism growth (GO:0040018)3.70709330
62heart valve morphogenesis (GO:0003179)3.63747043
63cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.60290825
64positive regulation of gamma-delta T cell activation (GO:0046645)3.58343621
65activation of MAPKKK activity (GO:0000185)3.56739131
66macrophage activation (GO:0042116)3.52984001
67mesodermal cell differentiation (GO:0048333)3.52560263
68positive regulation of p38MAPK cascade (GO:1900745)3.43897898
69desmosome organization (GO:0002934)3.41232459
70positive regulation of wound healing (GO:0090303)3.40671020
71positive regulation of bone remodeling (GO:0046852)3.40331818
72positive regulation of bone resorption (GO:0045780)3.40331818
73regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.35564568
74positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)3.33332429
75bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33207264
76embryonic cranial skeleton morphogenesis (GO:0048701)3.30448669
77regulation of gamma-delta T cell differentiation (GO:0045586)3.30270510
78lateral sprouting from an epithelium (GO:0060601)3.28314010
79hepatocyte apoptotic process (GO:0097284)3.25158435
80water homeostasis (GO:0030104)3.25045250
81positive regulation of receptor-mediated endocytosis (GO:0048260)3.24784052
82positive regulation of mast cell activation involved in immune response (GO:0033008)3.24781530
83positive regulation of mast cell degranulation (GO:0043306)3.24781530
84negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23409990
85negative regulation of cell killing (GO:0031342)3.23409990
86dendritic spine morphogenesis (GO:0060997)3.21897860
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18632422
88regulation of B cell receptor signaling pathway (GO:0050855)3.14565800
89negative regulation of granulocyte differentiation (GO:0030853)3.11358917
90interferon-gamma secretion (GO:0072643)3.11054517
91L-ascorbic acid metabolic process (GO:0019852)3.10940044
92regulation of mitochondrial membrane permeability (GO:0046902)3.10052881
93endothelial cell morphogenesis (GO:0001886)3.09315738
94activated T cell proliferation (GO:0050798)3.06939715
95positive regulation of mast cell activation (GO:0033005)3.06241033
96cell aggregation (GO:0098743)3.05764224
97cartilage condensation (GO:0001502)3.05764224
98folic acid transport (GO:0015884)3.02692018
99regulation of membrane permeability (GO:0090559)3.01056033
100regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.98331291
101chondrocyte differentiation (GO:0002062)2.97857892
102antimicrobial humoral response (GO:0019730)2.96491039
103antibacterial humoral response (GO:0019731)2.96038873
104positive regulation of cartilage development (GO:0061036)2.93431573
105pharyngeal system development (GO:0060037)2.92227946
106regulation of gamma-delta T cell activation (GO:0046643)2.90311215
107retinoic acid metabolic process (GO:0042573)2.90270882
108negative regulation of actin filament bundle assembly (GO:0032232)2.90182375
109regulation of secondary heart field cardioblast proliferation (GO:0003266)2.89133073
110regulation of cardioblast proliferation (GO:0003264)2.89133073
111myeloid cell activation involved in immune response (GO:0002275)2.88856493
112prostaglandin metabolic process (GO:0006693)2.88185071
113prostanoid metabolic process (GO:0006692)2.88185071
114positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.85754580
115regulation of interferon-beta biosynthetic process (GO:0045357)2.85162284
116chondrocyte development (GO:0002063)2.79353083
117tooth mineralization (GO:0034505)2.78966761
118positive regulation of leukocyte degranulation (GO:0043302)2.78921050
119regulation of platelet aggregation (GO:0090330)2.77752405
120cytokine production involved in immune response (GO:0002367)2.77252425
121regulation of epidermal cell differentiation (GO:0045604)2.76195339
122regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.75774524
123phospholipid efflux (GO:0033700)2.75024122
124hydrogen peroxide biosynthetic process (GO:0050665)2.74574748
125positive regulation of blood coagulation (GO:0030194)2.74514568
126positive regulation of hemostasis (GO:1900048)2.74514568
127regulation of p38MAPK cascade (GO:1900744)2.74095283
128bone remodeling (GO:0046849)2.74028120
129mesenchymal cell proliferation (GO:0010463)2.72314156
130regulation of triglyceride catabolic process (GO:0010896)2.70657591
131detection of other organism (GO:0098543)2.70425980
132regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.69837886
133collagen fibril organization (GO:0030199)2.69580104
134positive regulation of extracellular matrix organization (GO:1903055)2.67805271
135regulation of mast cell degranulation (GO:0043304)2.66241731
136embryonic skeletal joint morphogenesis (GO:0060272)2.65978525
137positive regulation of coagulation (GO:0050820)2.65726294
138detection of bacterium (GO:0016045)2.65459410
139cardiac ventricle morphogenesis (GO:0003208)2.64372035
140retinol metabolic process (GO:0042572)2.64145056
141metanephric mesenchyme development (GO:0072075)2.63435571
142iron ion import (GO:0097286)2.63255906
143regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.62898288
144leukocyte aggregation (GO:0070486)2.62293795
145cell proliferation involved in kidney development (GO:0072111)2.61471920
146positive regulation of regulated secretory pathway (GO:1903307)2.61278432
147labyrinthine layer development (GO:0060711)2.60585030
148positive regulation of odontogenesis (GO:0042482)2.59780115
149plasma membrane repair (GO:0001778)2.59362103
150lung-associated mesenchyme development (GO:0060484)2.59221716
151negative regulation of chondrocyte differentiation (GO:0032331)2.57957802
152positive regulation of catenin import into nucleus (GO:0035413)2.57665673
153regulation of B cell differentiation (GO:0045577)2.57020220
154cranial nerve morphogenesis (GO:0021602)2.56014280
155regulation of osteoblast proliferation (GO:0033688)2.55853600
156endodermal cell differentiation (GO:0035987)2.55721361
157regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)2.55403335
158surfactant homeostasis (GO:0043129)2.54825553
159hormone catabolic process (GO:0042447)2.54173894
160intestinal absorption (GO:0050892)2.54042874
161negative regulation of platelet activation (GO:0010544)2.53803255
162positive regulation of steroid hormone secretion (GO:2000833)2.53778676
163righting reflex (GO:0060013)2.53684495
164response to gravity (GO:0009629)2.53139421
165vitamin transmembrane transport (GO:0035461)2.53048224
166negative regulation of hormone metabolic process (GO:0032351)2.52690385
167negative regulation of hormone biosynthetic process (GO:0032353)2.52690385
168cardiac epithelial to mesenchymal transition (GO:0060317)2.52095920
169male meiosis I (GO:0007141)2.50060484
170positive regulation of B cell differentiation (GO:0045579)2.49952236
171regulation of skeletal muscle contraction (GO:0014819)2.49518064
172regulation of platelet activation (GO:0010543)2.49507661
173regulation of mast cell activation involved in immune response (GO:0033006)2.49330854
174negative regulation of epithelial cell differentiation (GO:0030857)2.48412495
175positive regulation of mesenchymal cell proliferation (GO:0002053)2.46978796
176cell adhesion mediated by integrin (GO:0033627)2.46588830
177positive thymic T cell selection (GO:0045059)2.46471733
178dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44143111
179neutrophil activation involved in immune response (GO:0002283)2.43260327
180definitive hemopoiesis (GO:0060216)2.42457481
181heart valve formation (GO:0003188)2.42004059
182reactive oxygen species biosynthetic process (GO:1903409)2.41453844
183interferon-gamma production (GO:0032609)2.41326079
184antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41007199
185positive regulation of JAK-STAT cascade (GO:0046427)2.40727561
186positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40192531
187negative regulation of bone mineralization (GO:0030502)2.37412470
188positive regulation of Rac GTPase activity (GO:0032855)2.37133600
189phospholipid homeostasis (GO:0055091)2.35213568
190activation of protein kinase A activity (GO:0034199)2.30866321
191negative regulation of lymphocyte mediated immunity (GO:0002707)2.29405134
192regulation of homotypic cell-cell adhesion (GO:0034110)2.29331350
193negative regulation of T cell mediated immunity (GO:0002710)2.28828935
194positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.27132418
195negative thymic T cell selection (GO:0045060)2.26843272
196negative regulation of myotube differentiation (GO:0010832)2.26791175
197regulation of activation of Janus kinase activity (GO:0010533)16.8632248
198growth hormone receptor signaling pathway (GO:0060396)16.6118628
199cellular response to growth hormone stimulus (GO:0071378)14.7370962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.13208282
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.09377586
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.28556660
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83585468
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.54108649
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03662315
7RUNX_20019798_ChIP-Seq_JUKART_Human2.84902914
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.73688282
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.67012438
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.63574618
11EZH2_22144423_ChIP-Seq_EOC_Human2.56641886
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.55401290
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.50507631
14AR_21572438_ChIP-Seq_LNCaP_Human2.48368973
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.45813828
16* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.31243426
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29822297
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.19010114
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09404598
20AHR_22903824_ChIP-Seq_MCF-7_Human2.08018633
21TP53_18474530_ChIP-ChIP_U2OS_Human2.04667395
22* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.99326980
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94543545
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90861692
25RXR_22108803_ChIP-Seq_LS180_Human1.88638099
26DROSHA_22980978_ChIP-Seq_HELA_Human1.77370832
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.76797894
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.71890887
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.71418003
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.70036545
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69705142
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68137625
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67735232
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67321447
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65140883
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64696612
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.61641050
38SPI1_23127762_ChIP-Seq_K562_Human1.60469976
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.59799370
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57839307
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57839307
42MYB_26560356_Chip-Seq_TH2_Human1.56768535
43CJUN_26792858_Chip-Seq_BT549_Human1.56551192
44UTX_26944678_Chip-Seq_JUKART_Human1.56248393
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56037914
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52752646
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52464296
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51288066
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49820702
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48675212
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47134967
52VDR_21846776_ChIP-Seq_THP-1_Human1.43874740
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.43607764
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43334013
55GBX2_23144817_ChIP-Seq_PC3_Human1.43145723
56* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42982003
57VDR_24763502_ChIP-Seq_THP-1_Human1.42477635
58* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41891426
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40812641
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40606286
61* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38067623
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37355238
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37355238
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.36727389
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36351114
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34132410
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32693794
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32513920
69FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31170028
70MAF_26560356_Chip-Seq_TH1_Human1.30967758
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30180260
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30007634
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29936971
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29936971
75* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29604814
76* STAT1_20625510_ChIP-Seq_HELA_Human1.27732861
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27175754
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26603209
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.26390754
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.25924660
81* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25830693
82* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25682719
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.25407280
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23598522
85* EP300_21415370_ChIP-Seq_HL-1_Mouse1.23352162
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23013988
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21015288
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20782137
89SCL_19346495_ChIP-Seq_HPC-7_Human1.19279898
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.18893968
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17250615
92TP53_16413492_ChIP-PET_HCT116_Human1.16776652
93* SOX2_20726797_ChIP-Seq_SW620_Human1.15817253
94KDM2B_26808549_Chip-Seq_DND41_Human1.14452646
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12341983
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.12234509
97SPI1_23547873_ChIP-Seq_NB4_Human1.12125048
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.11946796
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10318705
100MYB_26560356_Chip-Seq_TH1_Human1.10210119
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.09674414
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09193764
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09031867
104TCF7_22412390_ChIP-Seq_EML_Mouse1.08417050
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08294399
106* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08058513
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.07724031
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07650206
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07161452
110VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06640181
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06303041
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04866646
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04426994
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03067037
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03004727
116MYC_27129775_Chip-Seq_CORNEA_Mouse1.01714996
117LXR_22158963_ChIP-Seq_LIVER_Mouse1.00384382
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00320395
119GATA1_19941826_ChIP-Seq_K562_Human1.00182730
120* TP63_23658742_ChIP-Seq_EP156T_Human0.99181238
121* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98517973
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97987385
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96720362
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96425273
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96250684
126JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96209507
127* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96180457
128JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95740008
129* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95675987
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95661801
131* EZH2_27294783_Chip-Seq_ESCs_Mouse0.95601764
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95106559
133RUNX1_27514584_Chip-Seq_MCF-7_Human0.93252001
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92965528
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92630293
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.92373155
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92268326
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92091449
139ZNF263_19887448_ChIP-Seq_K562_Human0.91797766
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91604926
141VDR_24787735_ChIP-Seq_THP-1_Human0.90986026
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90925930
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90851588
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90808101
145KLF5_25053715_ChIP-Seq_YYC3_Human0.89055455
146ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88417051
147SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88165990
148* NFE2_27457419_Chip-Seq_LIVER_Mouse0.87662293
149* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87556735
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87350650
151SMRT_27268052_Chip-Seq_Bcells_Human0.87139468
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.86899793
153IGF1R_20145208_ChIP-Seq_DFB_Human0.86101678
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.85936369
155BRD4_25478319_ChIP-Seq_HGPS_Human0.85934998
156* SMAD4_21799915_ChIP-Seq_A2780_Human0.84990097
157CLOCK_20551151_ChIP-Seq_293T_Human0.84557872
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.84436969
159* GATA3_27048872_Chip-Seq_THYMUS_Human0.84238925
160CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83791353
161GATA3_26560356_Chip-Seq_TH2_Human0.83427021
162TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83141016
163* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83050463
164* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82791534
165* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82604378
166* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82453354
167BCL6_27268052_Chip-Seq_Bcells_Human0.82233762
168CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81990601
169CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81332586
170TCF4_22108803_ChIP-Seq_LS180_Human0.81239491
171BCAT_22108803_ChIP-Seq_LS180_Human0.80945739
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80323506
173* SMAD4_21741376_ChIP-Seq_EPCs_Human0.79389475
174SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.78816761
175KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78432309
176KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78432309
177KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78432309
178FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76144579
179FOXA1_25329375_ChIP-Seq_VCAP_Human0.76144579
180CTCF_21964334_ChIP-Seq_BJAB-B_Human0.75767897
181TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74485458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.62175727
2MP0001346_abnormal_lacrimal_gland4.57850065
3MP0002877_abnormal_melanocyte_morpholog4.51166512
4MP0002254_reproductive_system_inflammat3.91852961
5MP0000566_synostosis3.87791669
6MP0001348_abnormal_lacrimal_gland3.72238640
7MP0000762_abnormal_tongue_morphology3.21096326
8MP0003183_abnormal_peptide_metabolism3.17798393
9MP0002139_abnormal_hepatobiliary_system3.09348021
10MP0010368_abnormal_lymphatic_system3.09152618
11MP0003724_increased_susceptibility_to3.02610525
12MP0001299_abnormal_eye_distance/2.82186969
13MP0001835_abnormal_antigen_presentation2.43595404
14MP0002282_abnormal_trachea_morphology2.34334198
15MP0001800_abnormal_humoral_immune2.32914926
16MP0000767_abnormal_smooth_muscle2.26787985
17MP0002098_abnormal_vibrissa_morphology2.24909913
18MP0003300_gastrointestinal_ulcer2.18467824
19MP0009250_abnormal_appendicular_skeleto2.16289681
20MP0004043_abnormal_pH_regulation2.15625052
21MP0004130_abnormal_muscle_cell2.14158216
22MP0002060_abnormal_skin_morphology2.08068988
23MP0003303_peritoneal_inflammation2.06611184
24MP0005451_abnormal_body_composition10.3277974
25MP0002723_abnormal_immune_serum1.98895725
26MP0009053_abnormal_anal_canal1.98454677
27MP0000579_abnormal_nail_morphology1.95990161
28MP0000537_abnormal_urethra_morphology1.90788938
29MP0005671_abnormal_response_to1.90431968
30MP0003566_abnormal_cell_adhesion1.89494265
31MP0001958_emphysema1.88361298
32MP0008789_abnormal_olfactory_epithelium1.86406431
33MP0000383_abnormal_hair_follicle1.86367286
34MP0002419_abnormal_innate_immunity1.84399508
35MP0003941_abnormal_skin_development1.83127683
36MP0002452_abnormal_antigen_presenting1.82663195
37MP0003436_decreased_susceptibility_to1.81607194
38MP0000049_abnormal_middle_ear1.79902801
39MP0000163_abnormal_cartilage_morphology1.76583734
40MP0002420_abnormal_adaptive_immunity1.76529445
41MP0001819_abnormal_immune_cell1.74310323
42MP0002234_abnormal_pharynx_morphology1.74266094
43MP0005025_abnormal_response_to1.73026592
44MP0005275_abnormal_skin_tensile1.72880623
45MP0002896_abnormal_bone_mineralization1.72849042
46MP0004381_abnormal_hair_follicle1.70790478
47MP0003828_pulmonary_edema1.69316992
48MP0005508_abnormal_skeleton_morphology1.69007240
49MP0003279_aneurysm1.68711602
50MP0008875_abnormal_xenobiotic_pharmacok1.68010926
51MP0000678_abnormal_parathyroid_gland1.64372560
52MP0009384_cardiac_valve_regurgitation1.63455034
53MP0000467_abnormal_esophagus_morphology1.62552753
54MP0001666_abnormal_nutrient_absorption1.61143706
55MP0002796_impaired_skin_barrier1.56944335
56MP0004272_abnormal_basement_membrane1.50884617
57MP0004019_abnormal_vitamin_homeostasis1.49981054
58MP0001873_stomach_inflammation1.49386872
59MP0001790_abnormal_immune_system1.48798618
60MP0005387_immune_system_phenotype1.48798618
61MP0002405_respiratory_system_inflammati1.47735127
62MP0008961_abnormal_basal_metabolism1.47430416
63MP0008438_abnormal_cutaneous_collagen1.46538433
64MP0005248_abnormal_Harderian_gland1.45136537
65MP0002132_abnormal_respiratory_system1.43722847
66MP0002233_abnormal_nose_morphology1.43022574
67MP0000647_abnormal_sebaceous_gland1.41877053
68MP0009785_altered_susceptibility_to1.41797955
69MP0001849_ear_inflammation1.39112502
70MP0005000_abnormal_immune_tolerance1.37580222
71MP0010678_abnormal_skin_adnexa1.34130011
72MP0002148_abnormal_hypersensitivity_rea1.32706261
73MP0002249_abnormal_larynx_morphology1.28110060
74MP0000613_abnormal_salivary_gland1.27051170
75MP0001879_abnormal_lymphatic_vessel1.25777775
76MP0000749_muscle_degeneration1.25707830
77MP0005503_abnormal_tendon_morphology1.24991039
78MP0004883_abnormal_blood_vessel1.24517918
79MP0010352_gastrointestinal_tract_polyps1.24320776
80MP0005670_abnormal_white_adipose1.23916690
81MP0002398_abnormal_bone_marrow1.23255123
82MP0003191_abnormal_cellular_cholesterol1.22682665
83MP0004947_skin_inflammation1.22616736
84MP0002933_joint_inflammation1.21221255
85MP0003755_abnormal_palate_morphology1.18864661
86MP0005408_hypopigmentation1.18306757
87MP0005464_abnormal_platelet_physiology1.18230184
88MP0003011_delayed_dark_adaptation1.18074041
89MP0000716_abnormal_immune_system1.17948473
90MP0001542_abnormal_bone_strength1.17932209
91MP0009840_abnormal_foam_cell1.16815993
92MP0002909_abnormal_adrenal_gland1.15663753
93MP0000377_abnormal_hair_follicle1.15575503
94MP0002998_abnormal_bone_remodeling1.14659701
95MP0003866_abnormal_defecation1.13066005
96MP0003937_abnormal_limbs/digits/tail_de1.11920835
97MP0009115_abnormal_fat_cell1.11513337
98MP0003935_abnormal_craniofacial_develop1.07044707
99MP0002115_abnormal_skeleton_extremities1.06734837
100MP0003763_abnormal_thymus_physiology1.06150784
101MP0005023_abnormal_wound_healing1.06010823
102MP0000750_abnormal_muscle_regeneration1.05911669
103MP0000703_abnormal_thymus_morphology1.04852887
104MP0004134_abnormal_chest_morphology1.04659811
105MP0010771_integument_phenotype1.04428239
106MP0002116_abnormal_craniofacial_bone1.04285716
107MP0000432_abnormal_head_morphology1.02377979
108MP0001188_hyperpigmentation1.02259303
109MP0004782_abnormal_surfactant_physiolog1.02194305
110MP0001216_abnormal_epidermal_layer1.01872213
111MP0002722_abnormal_immune_system1.01041016
112MP0001270_distended_abdomen1.00046040
113MP0003045_fibrosis0.99900858
114MP0006082_CNS_inflammation0.99662342
115MP0005595_abnormal_vascular_smooth0.99133164
116MP0002113_abnormal_skeleton_development0.98268058
117MP0001915_intracranial_hemorrhage0.98063512
118MP0010155_abnormal_intestine_physiology0.97999585
119MP0002177_abnormal_outer_ear0.97756803
120MP0009764_decreased_sensitivity_to0.96867405
121MP0005390_skeleton_phenotype0.95667287
122MP0001765_abnormal_ion_homeostasis0.95632449
123MP0003705_abnormal_hypodermis_morpholog0.94590476
124MP0002735_abnormal_chemical_nociception0.93817154
125MP0005164_abnormal_response_to0.92953445
126MP0002166_altered_tumor_susceptibility0.91740243
127MP0003195_calcinosis0.91440175
128MP0002932_abnormal_joint_morphology0.89354667
129MP0009780_abnormal_chondrocyte_physiolo0.89187543
130MP0010234_abnormal_vibrissa_follicle0.89015495
131MP0001177_atelectasis0.88613970
132MP0000428_abnormal_craniofacial_morphol0.88282471
133MP0001663_abnormal_digestive_system0.87733639
134MP0001851_eye_inflammation0.87727332
135MP0000470_abnormal_stomach_morphology0.87404367
136MP0002133_abnormal_respiratory_system0.86835563
137MP0005388_respiratory_system_phenotype0.86835563
138MP0002089_abnormal_postnatal_growth/wei0.86516109
139MP0001845_abnormal_inflammatory_respons0.86095783
140MP0000685_abnormal_immune_system0.85480990
141MP0000751_myopathy0.85122279
142MP0003385_abnormal_body_wall0.83618318
143MP0002111_abnormal_tail_morphology0.83312241
144MP0009333_abnormal_splenocyte_physiolog0.83300397
145MP0000689_abnormal_spleen_morphology0.83228857
146MP0002429_abnormal_blood_cell0.83003070
147MP0001533_abnormal_skeleton_physiology0.81956621
148MP0003115_abnormal_respiratory_system0.81853365
149MP0005165_increased_susceptibility_to0.81337644
150MP0000569_abnormal_digit_pigmentation0.81203264
151MP0000538_abnormal_urinary_bladder0.79720355
152MP0003453_abnormal_keratinocyte_physiol0.78841632
153MP0002109_abnormal_limb_morphology0.78247883
154MP0005310_abnormal_salivary_gland0.77139342
155MP0005409_darkened_coat_color0.76711170
156MP0008007_abnormal_cellular_replicative0.75250463
157MP0002928_abnormal_bile_duct0.74692196
158MP0006054_spinal_hemorrhage0.74088588
159MP0010630_abnormal_cardiac_muscle0.72976159
160MP0002108_abnormal_muscle_morphology0.72768410
161MP0002127_abnormal_cardiovascular_syste0.72494733
162MP0002168_other_aberrant_phenotype0.72271281
163MP0000465_gastrointestinal_hemorrhage0.71904909
164MP0003943_abnormal_hepatobiliary_system0.69835890
165MP0004510_myositis0.68424491
166MP0005499_abnormal_olfactory_system0.67917530
167MP0005394_taste/olfaction_phenotype0.67917530
168MP0004084_abnormal_cardiac_muscle0.67350570
169MP0005423_abnormal_somatic_nervous0.66891116
170MP0000681_abnormal_thyroid_gland0.66572016
171MP0005075_abnormal_melanosome_morpholog0.65958875
172MP0003646_muscle_fatigue0.65567292
173MP0000249_abnormal_blood_vessel0.64555280
174MP0000858_altered_metastatic_potential0.63769355
175MP0008469_abnormal_protein_level0.63649961
176MP0006138_congestive_heart_failure0.62194416
177MP0002277_abnormal_respiratory_mucosa0.62011333
178MP0008872_abnormal_physiological_respon0.61985406
179MP0000427_abnormal_hair_cycle0.60548606
180MP0003283_abnormal_digestive_organ0.59461327

Predicted human phenotypes

RankGene SetZ-score
1Severe short stature (HP:0003510)7.62878850
2Growth hormone deficiency (HP:0000824)6.14829217
3Eczematoid dermatitis (HP:0000976)5.34776755
4Epiphyseal dysplasia (HP:0002656)4.99129927
5Onycholysis (HP:0001806)4.75515826
6Distal lower limb muscle weakness (HP:0009053)4.20551907
7Stomatitis (HP:0010280)4.15394887
8Hyperactive renin-angiotensin system (HP:0000841)4.01761697
9Irregular epiphyses (HP:0010582)3.94406994
10Vitreoretinal degeneration (HP:0000655)3.91549697
11Hypoplastic ischia (HP:0003175)3.83739338
12Oligodontia (HP:0000677)3.82502281
13Aplasia involving bones of the upper limbs (HP:0009823)3.69491251
14Aplasia of the phalanges of the hand (HP:0009802)3.69491251
15Aplasia involving bones of the extremities (HP:0009825)3.69491251
16Hypobetalipoproteinemia (HP:0003563)3.67605141
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.67212718
18Abnormality of the phalanges of the 2nd finger (HP:0009541)3.66262374
19Recurrent bacterial skin infections (HP:0005406)3.61293284
20Atrophic scars (HP:0001075)3.59511593
21Hemiplegia (HP:0002301)3.59058050
22Obstructive sleep apnea (HP:0002870)3.54980763
23Recurrent fungal infections (HP:0002841)3.53245243
24Milia (HP:0001056)3.47657938
25Pustule (HP:0200039)3.45843480
26Recurrent gram-negative bacterial infections (HP:0005420)3.45141746
27Increased circulating renin level (HP:0000848)3.41599715
28Premature rupture of membranes (HP:0001788)3.39328118
29Abnormality of the ischium (HP:0003174)3.35673928
30Gastrointestinal stroma tumor (HP:0100723)3.30579585
31Cupped ribs (HP:0000887)3.24981127
32Premature skin wrinkling (HP:0100678)3.21212866
33Fragile skin (HP:0001030)3.17690999
34Flat capital femoral epiphysis (HP:0003370)3.16904901
35Neonatal short-limb short stature (HP:0008921)3.11676177
36Short nail (HP:0001799)3.11137123
37Constricted visual fields (HP:0001133)3.09748888
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.09193067
39Deep palmar crease (HP:0006191)3.07851398
40Abnormality of incisor morphology (HP:0011063)3.01138488
41Recurrent abscess formation (HP:0002722)2.99462031
42Abnormality of the distal phalanges of the toes (HP:0010182)2.99210894
43Myositis (HP:0100614)2.95692019
44Neoplasm of the heart (HP:0100544)2.92531615
45Selective tooth agenesis (HP:0001592)2.90678081
46T lymphocytopenia (HP:0005403)2.89514205
47Right ventricular cardiomyopathy (HP:0011663)2.87066558
48Abnormality of the 2nd finger (HP:0004100)2.86097444
49Increased connective tissue (HP:0009025)2.85446850
50Synostosis involving the elbow (HP:0003938)2.83728305
51Humeroradial synostosis (HP:0003041)2.83728305
52Small epiphyses (HP:0010585)2.82390784
53Abnormality of the middle phalanges of the toes (HP:0010183)2.81444837
54Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.79990050
55Delayed epiphyseal ossification (HP:0002663)2.79823262
56Alopecia of scalp (HP:0002293)2.78076637
57Mitral stenosis (HP:0001718)2.78042268
58Vasculitis (HP:0002633)2.75550344
59Submucous cleft hard palate (HP:0000176)2.72203799
60Fragile nails (HP:0001808)2.69507270
61Amelogenesis imperfecta (HP:0000705)2.69218373
62Papilledema (HP:0001085)2.67701874
63Vertebral arch anomaly (HP:0008438)2.63377736
64Prolonged bleeding time (HP:0003010)2.58000546
65Mixed hearing impairment (HP:0000410)2.57746218
66Mediastinal lymphadenopathy (HP:0100721)2.57258209
67Abnormality of T cell number (HP:0011839)2.53878780
68Subacute progressive viral hepatitis (HP:0006572)2.48935009
69Abnormality of macrophages (HP:0004311)2.47365421
70Bell-shaped thorax (HP:0001591)2.47100833
71Absent frontal sinuses (HP:0002688)2.46375826
72Orchitis (HP:0100796)2.44229816
73Follicular hyperkeratosis (HP:0007502)2.44194772
74Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.44047140
75Short hallux (HP:0010109)2.44043102
76Stomach cancer (HP:0012126)2.42536145
77Menstrual irregularities (HP:0000858)2.41473467
78Osteomalacia (HP:0002749)2.41073443
79Recurrent bronchitis (HP:0002837)2.40295946
80Tetany (HP:0001281)2.38857842
81Large eyes (HP:0001090)2.38750962
82Abnormality of the frontal sinuses (HP:0002687)2.38124649
83Distal lower limb amyotrophy (HP:0008944)2.37465349
84Lymphopenia (HP:0001888)2.36847328
85Obstructive lung disease (HP:0006536)2.33115096
86Chronic obstructive pulmonary disease (HP:0006510)2.33115096
87Recurrent viral infections (HP:0004429)2.31611852
88Osteoarthritis (HP:0002758)2.30923213
89Hypokalemic alkalosis (HP:0001949)2.30001339
90Split foot (HP:0001839)2.29675585
91Papilloma (HP:0012740)2.29397487
92Verrucae (HP:0200043)2.29397487
93Abnormality of fatty-acid metabolism (HP:0004359)2.27718990
94Abnormal vertebral ossification (HP:0100569)2.27541371
95Optic neuritis (HP:0100653)2.27207222
96Retrobulbar optic neuritis (HP:0100654)2.27207222
97Recurrent skin infections (HP:0001581)2.27165799
98Genu varum (HP:0002970)2.26416950
99Deformed sella turcica (HP:0002681)2.26322957
100Epistaxis (HP:0000421)2.24223977
101Spontaneous hematomas (HP:0007420)2.23248708
102Abnormality of the phalanges of the 5th finger (HP:0004213)2.23077703
103Striae distensae (HP:0001065)2.22803882
104Hematochezia (HP:0002573)2.22370949
105Hypoplasia of dental enamel (HP:0006297)2.22055290
106Lip pit (HP:0100267)2.20998323
107Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.20514304
108Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.19033495
109Metabolic alkalosis (HP:0200114)2.18851823
110Flat acetabular roof (HP:0003180)2.17479730
111Neurodegeneration (HP:0002180)2.17180194
112Elevated erythrocyte sedimentation rate (HP:0003565)2.16026234
113Muscle fiber splitting (HP:0003555)2.15705372
114Hyperaldosteronism (HP:0000859)2.14525949
115Bronchomalacia (HP:0002780)2.14342490
116Gingivitis (HP:0000230)2.14341338
117Spinal rigidity (HP:0003306)2.10812820
118Eosinophilia (HP:0001880)2.10803372
119Abnormality of the middle phalanges of the hand (HP:0009833)2.10747388
120Choroideremia (HP:0001139)2.10726984
121Mild short stature (HP:0003502)2.10116602
122Meningitis (HP:0001287)2.08530949
123Metaphyseal cupping (HP:0003021)2.08513399
124Aplasia/Hypoplasia of the hallux (HP:0008362)2.07983189
125Emphysema (HP:0002097)2.07861196
126Down-sloping shoulders (HP:0200021)2.06513720
127Ulnar bowing (HP:0003031)2.04559319
128Chest pain (HP:0100749)2.04503487
129Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02998269
130Abnormality of T cells (HP:0002843)2.02637015
131Esophageal atresia (HP:0002032)2.02450453
132Plantar hyperkeratosis (HP:0007556)2.02136234
133Gastrointestinal infarctions (HP:0005244)2.00497393
134Leukocytosis (HP:0001974)1.98745178
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.98132521
136Abnormality of femoral epiphyses (HP:0006499)1.98019938
137Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.98019938
138Joint swelling (HP:0001386)1.97957375
139Hypercalciuria (HP:0002150)1.97700699
140Polygenic inheritance (HP:0010982)1.97372667
141Toxemia of pregnancy (HP:0100603)1.97170795
142Abnormality of the nasal septum (HP:0000419)1.96996069
143Abnormal tarsal ossification (HP:0008369)1.96969256
144Recurrent pneumonia (HP:0006532)1.96117787
145Cranial hyperostosis (HP:0004437)1.94725933
146Enlarged epiphyses (HP:0010580)1.94643006
147Keratoconjunctivitis sicca (HP:0001097)1.94516327
148Abnormality of the pubic bones (HP:0003172)1.94015098
149Abnormal platelet function (HP:0011869)1.93505450
150Impaired platelet aggregation (HP:0003540)1.93505450
151Osteolytic defects of the hand bones (HP:0009699)1.92739112
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.92739112
153Thoracic kyphosis (HP:0002942)1.92238596
154Shallow orbits (HP:0000586)1.89901375
155Keratoconjunctivitis (HP:0001096)1.89547184
156Lower limb amyotrophy (HP:0007210)1.88862593
157Pterygium (HP:0001059)1.88627879
158Limited elbow extension (HP:0001377)1.87300028
159Natal tooth (HP:0000695)1.87273816
160Hypochromic microcytic anemia (HP:0004840)1.86268044
161Hypoproteinemia (HP:0003075)1.85954687
162Arterial thrombosis (HP:0004420)1.85452295
163Abnormality of the vertebral endplates (HP:0005106)1.85185476
164Granulocytopenia (HP:0001913)1.85064191
165Duplicated collecting system (HP:0000081)1.84797978
166Conjunctival hamartoma (HP:0100780)1.84666259
167Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83988894
168Short 4th metacarpal (HP:0010044)1.83988894
169Spontaneous abortion (HP:0005268)1.83444086
170Hypomagnesemia (HP:0002917)1.82612092
171Popliteal pterygium (HP:0009756)1.82364063
172Pulmonary infiltrates (HP:0002113)1.82258231
173Arthralgia (HP:0002829)1.80628521
174Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80410561
175Thin ribs (HP:0000883)1.79252965
176Autoimmune hemolytic anemia (HP:0001890)1.78589087
177Spondylolisthesis (HP:0003302)1.78070553
178Abnormal delayed hypersensitivity skin test (HP:0002963)1.78040762
179Adrenal hypoplasia (HP:0000835)1.77534027
180Anosmia (HP:0000458)1.77379190
181Short femoral neck (HP:0100864)1.77249130
182Amyloidosis (HP:0011034)1.76078813
183Restrictive lung disease (HP:0002091)1.75337185
184Reduced subcutaneous adipose tissue (HP:0003758)1.74593825
185Platyspondyly (HP:0000926)1.73830089
186Abnormal platelet volume (HP:0011876)1.73734993
187Hypolipoproteinemia (HP:0010981)1.73720145
188Abnormality of the fingertips (HP:0001211)1.72823964
189Facial diplegia (HP:0001349)1.72669102
190Abnormality of B cell number (HP:0010975)1.70130018
191Hyporeflexia of lower limbs (HP:0002600)1.68756967
192Abnormality of the renal collecting system (HP:0004742)1.67510705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.21465311
2MAP4K14.86131167
3EPHA34.26192910
4MAP3K113.92062814
5MAP3K33.40078705
6EPHB23.28261713
7MST42.84182107
8JAK32.79154775
9DAPK22.78131886
10SGK22.59174070
11EPHB12.50998706
12STK38L2.45215921
13ERBB32.35027493
14PDK22.34449818
15MST1R2.34240800
16PRKD32.31301539
17GRK62.30216687
18RIPK42.30116575
19LATS12.30040790
20PIK3CG2.23827926
21SIK12.21257985
22FER2.15254274
23MAP3K22.14432807
24SGK32.13285104
25DDR22.08907993
26MKNK21.97883634
27KSR21.95681737
28SGK4941.93543166
29SGK2231.93543166
30BTK1.85580315
31TYK21.79827311
32TRPM71.78716255
33ZAP701.75940128
34SIK31.74945475
35FGFR21.74938398
36RPS6KB21.71710135
37CSK1.70545556
38BMPR1B1.67677974
39EPHA21.66884411
40FES1.63536826
41TXK1.62358762
42TNIK1.62042987
43CDK61.61554593
44HIPK21.58849934
45TAOK31.57033584
46TTN1.53891901
47IRAK41.47676295
48ITK1.46394296
49MAP3K131.43324810
50PTK2B1.43290391
51IKBKE1.41572904
52MAP2K41.40450805
53STK41.37604093
54SYK1.37311006
55FGFR41.35958367
56TEC1.35771531
57OXSR11.35072762
58NLK1.30854926
59MAP3K121.23513590
60FRK1.23231688
61PIM11.23189898
62HCK1.19786993
63NEK61.17877725
64JAK21.15544351
65BCR1.13894888
66CDK81.13333624
67TRIB31.13153976
68STK101.12488954
69INSRR1.09608950
70CSF1R1.08686265
71ZAK1.08598225
72MARK21.06048106
73WNK11.00181956
74LCK0.98709709
75IRAK10.98465062
76STK110.98409303
77MKNK10.97472407
78FGFR30.94192416
79LYN0.93932625
80ERBB20.88900584
81CAMKK10.88824609
82PIK3CA0.88775313
83WNK40.87860843
84STK390.86200540
85MAP3K70.85640378
86ALK0.85026993
87TLK10.84679511
88MAPK70.84026942
89PRKCE0.82118691
90NME10.82078688
91PRPF4B0.79844906
92STK240.79695550
93ACVR1B0.79110994
94CAMKK20.78098143
95MAPK150.76342020
96STK30.75434527
97TBK10.73106163
98MAP2K20.73053220
99CAMK1D0.71609666
100TGFBR10.71569432
101ERN10.71484106
102PDK10.70582028
103PRKAA20.70256548
104LATS20.68564052
105PDPK10.66144585
106YES10.64601399
107TNK20.62548916
108RAF10.62317526
109MET0.61841069
110MAP2K10.61545966
111PDGFRB0.61225371
112SGK10.60930423
113LRRK20.60544240
114CAMK40.58670919
115MAP2K30.55924260
116PRKG20.55527083
117PRKCQ0.54814836
118MATK0.54288389
119CAMK1G0.53797928
120PRKD10.51789033
121MAP3K10.51650448
122PDK40.51496655
123PDK30.51496655
124TYRO30.50781652
125MAP3K90.50328025
126BRD40.49857289
127FYN0.48819052
128BMX0.48159365
129BRAF0.47441254
130FGFR10.47282464
131KIT0.46548605
132JAK10.45048770
133CDK90.45005724
134ROCK10.44478934
135MAPK120.44053514
136FGR0.43889871
137RET0.43508606
138IKBKB0.42938699
139RPS6KA60.42833447
140MARK30.42444982
141STK380.39968187
142PINK10.39574364
143BMPR20.37672854
144NTRK30.37635589
145KSR10.37009639
146ADRBK10.36882862
147ROCK20.36629091
148CAMK10.36157191
149PTK60.36081422
150CAMK2D0.33992584
151PAK30.33421227
152IGF1R0.33345700
153PRKCD0.29775002
154MOS0.29562963
155TAOK10.29245874
156PHKG20.25870730
157PHKG10.25870730
158MUSK0.23575617
159TGFBR20.23247414
160CDK190.22571553
161CDC42BPA0.22309958
162NEK90.21662205
163PRKD20.21074022
164ADRBK20.19579897
165DYRK1A0.18496261
166CSNK1A10.18470342
167MAPKAPK20.18376285

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.95818079
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.79614747
3ECM-receptor interaction_Homo sapiens_hsa045123.74559136
4Caffeine metabolism_Homo sapiens_hsa002323.34772029
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.13049382
6Chemical carcinogenesis_Homo sapiens_hsa052043.08564179
7Fatty acid degradation_Homo sapiens_hsa000712.75458176
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.57216272
9Tyrosine metabolism_Homo sapiens_hsa003502.39072330
10Osteoclast differentiation_Homo sapiens_hsa043802.27053510
11Sulfur relay system_Homo sapiens_hsa041222.14885151
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.13091195
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.98337554
14Dilated cardiomyopathy_Homo sapiens_hsa054141.96577910
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.91894726
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.91833309
17TGF-beta signaling pathway_Homo sapiens_hsa043501.85671687
18Staphylococcus aureus infection_Homo sapiens_hsa051501.83600079
19Graft-versus-host disease_Homo sapiens_hsa053321.82630227
20Platelet activation_Homo sapiens_hsa046111.75720872
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74649160
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73822748
23B cell receptor signaling pathway_Homo sapiens_hsa046621.73633139
24Tuberculosis_Homo sapiens_hsa051521.73601047
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.70971112
26Retinol metabolism_Homo sapiens_hsa008301.67632402
27Non-small cell lung cancer_Homo sapiens_hsa052231.67195318
28T cell receptor signaling pathway_Homo sapiens_hsa046601.65299083
29Gastric acid secretion_Homo sapiens_hsa049711.58472146
30Basal cell carcinoma_Homo sapiens_hsa052171.54563410
31Other glycan degradation_Homo sapiens_hsa005111.53831825
32Pancreatic cancer_Homo sapiens_hsa052121.47518386
33Protein digestion and absorption_Homo sapiens_hsa049741.47134074
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43716038
35Focal adhesion_Homo sapiens_hsa045101.41540822
36Systemic lupus erythematosus_Homo sapiens_hsa053221.39097341
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31824268
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25693798
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25449989
40Proteoglycans in cancer_Homo sapiens_hsa052051.25385207
41Chemokine signaling pathway_Homo sapiens_hsa040621.24399794
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21906979
43Bladder cancer_Homo sapiens_hsa052191.21076980
44GnRH signaling pathway_Homo sapiens_hsa049121.20358651
45Viral myocarditis_Homo sapiens_hsa054161.19180594
46Hippo signaling pathway_Homo sapiens_hsa043901.18755278
47Allograft rejection_Homo sapiens_hsa053301.16352532
48Primary immunodeficiency_Homo sapiens_hsa053401.12826801
49Hedgehog signaling pathway_Homo sapiens_hsa043401.11587881
50Adherens junction_Homo sapiens_hsa045201.10499953
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.08476247
52Antigen processing and presentation_Homo sapiens_hsa046121.05477713
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04219187
54Chronic myeloid leukemia_Homo sapiens_hsa052201.02700144
55Phenylalanine metabolism_Homo sapiens_hsa003601.01055992
56Fatty acid metabolism_Homo sapiens_hsa012121.00583135
57beta-Alanine metabolism_Homo sapiens_hsa004100.98532081
58ABC transporters_Homo sapiens_hsa020100.97883981
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97244041
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96579470
61Linoleic acid metabolism_Homo sapiens_hsa005910.96211886
62Hepatitis B_Homo sapiens_hsa051610.96072391
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90937357
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.90759767
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.90190463
66Wnt signaling pathway_Homo sapiens_hsa043100.90051877
67Estrogen signaling pathway_Homo sapiens_hsa049150.89564694
68Fatty acid biosynthesis_Homo sapiens_hsa000610.88910908
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88771431
70Leishmaniasis_Homo sapiens_hsa051400.88673310
71Toxoplasmosis_Homo sapiens_hsa051450.88454171
72Oxytocin signaling pathway_Homo sapiens_hsa049210.87916865
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86575214
74Ovarian steroidogenesis_Homo sapiens_hsa049130.85316397
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84272443
76Measles_Homo sapiens_hsa051620.84234926
77Renal cell carcinoma_Homo sapiens_hsa052110.83763612
78Glioma_Homo sapiens_hsa052140.83683189
79Ras signaling pathway_Homo sapiens_hsa040140.83680748
80Malaria_Homo sapiens_hsa051440.82302067
81Morphine addiction_Homo sapiens_hsa050320.81857153
82Hepatitis C_Homo sapiens_hsa051600.81795853
83Propanoate metabolism_Homo sapiens_hsa006400.80432656
84Small cell lung cancer_Homo sapiens_hsa052220.79609270
85Bile secretion_Homo sapiens_hsa049760.78935275
86Axon guidance_Homo sapiens_hsa043600.78618216
87Amoebiasis_Homo sapiens_hsa051460.77811560
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77646874
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77239859
90Prolactin signaling pathway_Homo sapiens_hsa049170.77237271
91Arachidonic acid metabolism_Homo sapiens_hsa005900.77189231
92MicroRNAs in cancer_Homo sapiens_hsa052060.76598964
93Alcoholism_Homo sapiens_hsa050340.76563359
94Influenza A_Homo sapiens_hsa051640.74245322
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71826777
96Choline metabolism in cancer_Homo sapiens_hsa052310.71550409
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71384822
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71317709
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.70714806
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70187691
101Complement and coagulation cascades_Homo sapiens_hsa046100.69205255
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67305366
103Circadian rhythm_Homo sapiens_hsa047100.65081301
104Hematopoietic cell lineage_Homo sapiens_hsa046400.65040322
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.64198713
106Pathways in cancer_Homo sapiens_hsa052000.64129968
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63689619
108Vitamin digestion and absorption_Homo sapiens_hsa049770.63254571
109Endometrial cancer_Homo sapiens_hsa052130.63224459
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62424435
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62097174
112Cholinergic synapse_Homo sapiens_hsa047250.62040318
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60889887
114Prostate cancer_Homo sapiens_hsa052150.60594226
115Type I diabetes mellitus_Homo sapiens_hsa049400.60028844
116Melanoma_Homo sapiens_hsa052180.59589948
117Glutamatergic synapse_Homo sapiens_hsa047240.59380994
118PPAR signaling pathway_Homo sapiens_hsa033200.58790422
119Asthma_Homo sapiens_hsa053100.57904751
120Glutathione metabolism_Homo sapiens_hsa004800.57665746
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.57089157
122FoxO signaling pathway_Homo sapiens_hsa040680.56119097
123Gap junction_Homo sapiens_hsa045400.56004913
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53510201
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51662322
126TNF signaling pathway_Homo sapiens_hsa046680.50590498
127HTLV-I infection_Homo sapiens_hsa051660.50168241
128Salivary secretion_Homo sapiens_hsa049700.49943989
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49067807
130Nitrogen metabolism_Homo sapiens_hsa009100.48421478
131Melanogenesis_Homo sapiens_hsa049160.48237154
132VEGF signaling pathway_Homo sapiens_hsa043700.47442919
133Viral carcinogenesis_Homo sapiens_hsa052030.46558182
134Tight junction_Homo sapiens_hsa045300.45868336
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45587174
136Autoimmune thyroid disease_Homo sapiens_hsa053200.45175364
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43435741
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43287049
139Fatty acid elongation_Homo sapiens_hsa000620.42805610
140Rap1 signaling pathway_Homo sapiens_hsa040150.41447684
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40737856
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.40153335
143MAPK signaling pathway_Homo sapiens_hsa040100.37717537
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.36947570
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36669647
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34763311
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.33820892
148Calcium signaling pathway_Homo sapiens_hsa040200.33388165
149Dorso-ventral axis formation_Homo sapiens_hsa043200.31310559
150Histidine metabolism_Homo sapiens_hsa003400.30030315
151Notch signaling pathway_Homo sapiens_hsa043300.30021576
152Phagosome_Homo sapiens_hsa041450.28934000
153Sphingolipid metabolism_Homo sapiens_hsa006000.28708839
154Circadian entrainment_Homo sapiens_hsa047130.27779027
155Rheumatoid arthritis_Homo sapiens_hsa053230.24035099
156Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23301570
157HIF-1 signaling pathway_Homo sapiens_hsa040660.23269417
158Insulin resistance_Homo sapiens_hsa049310.22340213
159Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21562487
160Acute myeloid leukemia_Homo sapiens_hsa052210.21243921
161cAMP signaling pathway_Homo sapiens_hsa040240.20582816
162Lysine degradation_Homo sapiens_hsa003100.19191908
163ErbB signaling pathway_Homo sapiens_hsa040120.17201309
164Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16505836
165p53 signaling pathway_Homo sapiens_hsa041150.15347507
166Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.15164517

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