LGSN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of digestive system process (GO:0060457)9.48934357
2response to gravity (GO:0009629)9.03545090
3negative regulation of response to food (GO:0032096)8.21774214
4negative regulation of appetite (GO:0032099)8.21774214
5negative regulation of cell size (GO:0045792)7.65459902
6negative regulation of necrotic cell death (GO:0060547)7.05332956
7regulation of feeding behavior (GO:0060259)6.61061803
8homocysteine metabolic process (GO:0050667)6.58771078
9negative regulation of meiosis (GO:0045835)6.32395268
10positive regulation of calcium ion import (GO:0090280)5.58556856
11activation of protein kinase A activity (GO:0034199)5.38223210
12intra-S DNA damage checkpoint (GO:0031573)5.32776221
13negative regulation of response to extracellular stimulus (GO:0032105)5.21892508
14negative regulation of response to nutrient levels (GO:0032108)5.21892508
15superoxide metabolic process (GO:0006801)5.17329447
16regulation of response to food (GO:0032095)5.13430122
17kinetochore assembly (GO:0051382)4.95338776
18regulation of appetite (GO:0032098)4.71377832
19behavioral response to nicotine (GO:0035095)4.57237338
20aerobic respiration (GO:0009060)4.48344168
21response to redox state (GO:0051775)4.27234895
22piRNA metabolic process (GO:0034587)4.21445848
23negative regulation of phosphoprotein phosphatase activity (GO:0032515)4.17400977
24tryptophan catabolic process (GO:0006569)4.15092905
25indole-containing compound catabolic process (GO:0042436)4.15092905
26indolalkylamine catabolic process (GO:0046218)4.15092905
27response to pheromone (GO:0019236)4.12389014
28kinetochore organization (GO:0051383)4.12039766
29water-soluble vitamin biosynthetic process (GO:0042364)4.05020701
30regulation of triglyceride catabolic process (GO:0010896)3.97960101
31L-fucose catabolic process (GO:0042355)3.96972107
32fucose catabolic process (GO:0019317)3.96972107
33L-fucose metabolic process (GO:0042354)3.96972107
34mesenchymal-epithelial cell signaling (GO:0060638)3.95598978
35cellular ketone body metabolic process (GO:0046950)3.93745779
36indolalkylamine metabolic process (GO:0006586)3.93310011
37high-density lipoprotein particle remodeling (GO:0034375)3.89077512
38Rac protein signal transduction (GO:0016601)3.88860115
39negative regulation of meiotic cell cycle (GO:0051447)3.88361699
40amine catabolic process (GO:0009310)3.83539825
41cellular biogenic amine catabolic process (GO:0042402)3.83539825
42detection of light stimulus involved in sensory perception (GO:0050962)3.82331327
43detection of light stimulus involved in visual perception (GO:0050908)3.82331327
44positive regulation of smooth muscle cell migration (GO:0014911)3.80265534
45neuron remodeling (GO:0016322)3.79826312
46regulation of vascular permeability (GO:0043114)3.78555357
47cornea development in camera-type eye (GO:0061303)3.76904552
48positive regulation of DNA biosynthetic process (GO:2000573)3.74843784
49cellular response to exogenous dsRNA (GO:0071360)3.74487924
50kynurenine metabolic process (GO:0070189)3.72820689
51tryptophan metabolic process (GO:0006568)3.68672140
52temperature homeostasis (GO:0001659)3.68409250
53G-protein coupled receptor internalization (GO:0002031)3.65820975
54axonemal dynein complex assembly (GO:0070286)3.61950871
55cilium or flagellum-dependent cell motility (GO:0001539)3.61723952
56regulation of non-canonical Wnt signaling pathway (GO:2000050)3.60735267
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.55858023
58regulation of lipoprotein metabolic process (GO:0050746)3.55751791
59regulation of meiosis (GO:0040020)3.55503294
60ketone body metabolic process (GO:1902224)3.53709169
61platelet dense granule organization (GO:0060155)3.50180322
62epithelial cell maturation (GO:0002070)3.47057663
63regulation of histone deacetylation (GO:0031063)3.44494319
64positive regulation of vasodilation (GO:0045909)3.42443370
65mannosylation (GO:0097502)3.40344754
66cellular respiration (GO:0045333)3.36158303
67phospholipid homeostasis (GO:0055091)3.35241209
68positive regulation of collagen biosynthetic process (GO:0032967)3.35123515
69cellular response to interferon-beta (GO:0035458)3.34591622
70regulation of necrotic cell death (GO:0010939)3.33837089
71regulation of calcium ion import (GO:0090279)3.31670123
72DNA deamination (GO:0045006)3.31175404
73phospholipid efflux (GO:0033700)3.31096291
74glycosphingolipid biosynthetic process (GO:0006688)3.26070542
75positive regulation of collagen metabolic process (GO:0010714)3.24376041
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23788528
77axoneme assembly (GO:0035082)3.21968237
78regulation of glutamate receptor signaling pathway (GO:1900449)3.20342242
79regulation of digestive system process (GO:0044058)3.18379871
80oocyte maturation (GO:0001556)3.14623645
81regulation of helicase activity (GO:0051095)3.12747302
82DNA methylation involved in gamete generation (GO:0043046)3.12006920
83reverse cholesterol transport (GO:0043691)3.10873801
84sulfation (GO:0051923)3.07256860
85indole-containing compound metabolic process (GO:0042430)3.04320035
86positive regulation of cAMP-mediated signaling (GO:0043950)3.02918625
87epithelial cilium movement (GO:0003351)3.02684414
88transepithelial transport (GO:0070633)3.00018056
89female gonad development (GO:0008585)2.99722444
90positive regulation of heart contraction (GO:0045823)2.99039510
91respiratory chain complex IV assembly (GO:0008535)2.98326228
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97984994
93photoreceptor cell maintenance (GO:0045494)2.96219851
94preassembly of GPI anchor in ER membrane (GO:0016254)2.95480700
95S-adenosylmethionine metabolic process (GO:0046500)2.93011327
96protein complex biogenesis (GO:0070271)2.91802842
97positive regulation of protein kinase C signaling (GO:0090037)2.91658588
98neural tube formation (GO:0001841)2.91552005
99calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.91217494
100aromatic amino acid family catabolic process (GO:0009074)2.90254744
101positive regulation of RNA splicing (GO:0033120)2.90239957
102cellular response to gamma radiation (GO:0071480)2.89879538
103regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89584030
104dopamine transport (GO:0015872)2.89501739
105regulation of glycogen (starch) synthase activity (GO:2000465)2.88496862
106multicellular organism reproduction (GO:0032504)2.87946080
107positive regulation of prostaglandin secretion (GO:0032308)2.86928924
108regulation of glucokinase activity (GO:0033131)2.86681620
109regulation of hexokinase activity (GO:1903299)2.86681620
110muscle atrophy (GO:0014889)2.85513350
111regulation of meiotic cell cycle (GO:0051445)2.85179252
112regulation of collagen biosynthetic process (GO:0032965)2.84657276
113DNA synthesis involved in DNA repair (GO:0000731)2.84043120
114response to pain (GO:0048265)2.83105782
115protein K11-linked deubiquitination (GO:0035871)2.82409320
116gamma-aminobutyric acid transport (GO:0015812)2.79038910
117photoreceptor cell development (GO:0042461)2.77585243
118kidney morphogenesis (GO:0060993)2.77324329
119synaptonemal complex assembly (GO:0007130)2.76342988
120negative regulation of stem cell proliferation (GO:2000647)2.76324288
121regulation of cilium movement (GO:0003352)2.76111826
122reciprocal DNA recombination (GO:0035825)2.73732804
123reciprocal meiotic recombination (GO:0007131)2.73732804
124multicellular organismal homeostasis (GO:0048871)2.73713831
125nephron epithelium morphogenesis (GO:0072088)2.73391757
126nephron tubule morphogenesis (GO:0072078)2.73391757
127mitochondrial respiratory chain complex assembly (GO:0033108)2.72832977
128regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.72619660
129cytochrome complex assembly (GO:0017004)2.72550417
130negative regulation of behavior (GO:0048521)2.69553360
131regulation of hippo signaling (GO:0035330)2.69454189
132positive regulation of multicellular organismal metabolic process (GO:0044253)2.69365903
133diterpenoid biosynthetic process (GO:0016102)2.68996750
134cilium morphogenesis (GO:0060271)2.68723438
135lung-associated mesenchyme development (GO:0060484)2.68295570
136DNA integration (GO:0015074)2.68127067
137androgen metabolic process (GO:0008209)2.67975906
138regulation of synaptic transmission, glutamatergic (GO:0051966)2.67554644
139nonmotile primary cilium assembly (GO:0035058)2.67350276
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.66221021
141NADH dehydrogenase complex assembly (GO:0010257)2.66221021
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66221021
143negative regulation of mast cell activation (GO:0033004)2.63458248
144negative regulation of axon extension involved in axon guidance (GO:0048843)2.62869289
145protein localization to cilium (GO:0061512)2.62257007
146protein polyglutamylation (GO:0018095)2.61167352
147cholesterol efflux (GO:0033344)2.59556260
148plasma lipoprotein particle remodeling (GO:0034369)2.59319814
149protein-lipid complex remodeling (GO:0034368)2.59319814
150macromolecular complex remodeling (GO:0034367)2.59319814
151protein K6-linked ubiquitination (GO:0085020)2.59044490
152righting reflex (GO:0060013)2.56595420
153retinal cone cell development (GO:0046549)2.56347627
154male meiosis I (GO:0007141)2.55999257
155neuronal action potential (GO:0019228)2.55368163
156behavioral response to ethanol (GO:0048149)2.55084519
157positive regulation of fatty acid transport (GO:2000193)2.54854218
158protein-cofactor linkage (GO:0018065)2.54638282
159drug catabolic process (GO:0042737)2.53595990
160GPI anchor metabolic process (GO:0006505)2.53464399
161neuronal action potential propagation (GO:0019227)2.52951190
162RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52350590
163tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52350590
164purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.52339143
1653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.52339143
166regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51934462
167reflex (GO:0060004)2.51752793
168negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50886472
169citrulline biosynthetic process (GO:0019240)2.49944351
170striated muscle atrophy (GO:0014891)2.49779697
171pyrimidine nucleobase catabolic process (GO:0006208)2.49499775
172eye photoreceptor cell development (GO:0042462)2.49428066
173positive regulation of smoothened signaling pathway (GO:0045880)2.49075668
174cellular response to ATP (GO:0071318)2.49061616
175primary amino compound metabolic process (GO:1901160)2.48416442
176negative regulation of telomere maintenance (GO:0032205)2.47291477
177dendritic spine morphogenesis (GO:0060997)2.47218794
178negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46814244
179glycerophospholipid catabolic process (GO:0046475)2.46586609
180C4-dicarboxylate transport (GO:0015740)2.42618753
181branched-chain amino acid catabolic process (GO:0009083)2.42596528
182benzene-containing compound metabolic process (GO:0042537)2.41415588
183nucleobase catabolic process (GO:0046113)2.41333078
184anterograde synaptic vesicle transport (GO:0048490)2.41157321
185intraciliary transport (GO:0042073)2.40871235
186oxidative demethylation (GO:0070989)2.40522501
187aromatic amino acid family metabolic process (GO:0009072)2.40035009
188drinking behavior (GO:0042756)13.0263384
189positive regulation of vascular permeability (GO:0043117)11.9407062
190superoxide anion generation (GO:0042554)11.5578877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.11766660
2ZNF274_21170338_ChIP-Seq_K562_Hela3.85913340
3VDR_22108803_ChIP-Seq_LS180_Human3.26462664
4ZFP57_27257070_Chip-Seq_ESCs_Mouse3.24333221
5HTT_18923047_ChIP-ChIP_STHdh_Human3.16669070
6* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.75781555
7FUS_26573619_Chip-Seq_HEK293_Human2.74326052
8IGF1R_20145208_ChIP-Seq_DFB_Human2.62643671
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.61300359
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60031585
11* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.54368723
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.52555188
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.43579041
14GBX2_23144817_ChIP-Seq_PC3_Human2.41232011
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36572690
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29750088
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.29513412
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16106749
19DROSHA_22980978_ChIP-Seq_HELA_Human2.14875972
20* NFE2_27457419_Chip-Seq_LIVER_Mouse2.13951417
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13484233
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12625370
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.11590491
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07946714
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99574151
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99419649
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99171382
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98833769
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.98271170
30* FLI1_27457419_Chip-Seq_LIVER_Mouse1.97895513
31* EZH2_27294783_Chip-Seq_NPCs_Mouse1.97517662
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96296123
33TAF15_26573619_Chip-Seq_HEK293_Human1.95480722
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87979626
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.86747039
36RNF2_27304074_Chip-Seq_NSC_Mouse1.85781363
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85327305
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85327305
39REST_21632747_ChIP-Seq_MESCs_Mouse1.84803632
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83653828
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.83653828
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82248400
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75832584
44* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.75662135
45* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74921174
46* E2F1_18555785_Chip-Seq_ESCs_Mouse1.72300896
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70838199
48CBP_20019798_ChIP-Seq_JUKART_Human1.70838199
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70592942
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70265117
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69848538
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69565131
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69273253
54TP53_22573176_ChIP-Seq_HFKS_Human1.67841601
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66946294
56* NMYC_18555785_Chip-Seq_ESCs_Mouse1.65114952
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.64880478
58* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62522128
59* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.61330936
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.61174874
61* NANOG_18555785_Chip-Seq_ESCs_Mouse1.60822628
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60266515
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60020656
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58995502
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58858783
66BCAT_22108803_ChIP-Seq_LS180_Human1.57805725
67* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55123776
68* P53_22387025_ChIP-Seq_ESCs_Mouse1.54746375
69* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.54362430
70* SOX2_18555785_Chip-Seq_ESCs_Mouse1.53388190
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52897686
72* OCT4_18555785_Chip-Seq_ESCs_Mouse1.50909404
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50805878
74* CRX_20693478_ChIP-Seq_RETINA_Mouse1.50392838
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50287052
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49630537
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.49630537
78* STAT3_18555785_Chip-Seq_ESCs_Mouse1.47322702
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47286355
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.46848163
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.45042794
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44755830
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44637352
84* P300_18555785_Chip-Seq_ESCs_Mouse1.44636836
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44537775
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43859487
87* CMYC_18555785_Chip-Seq_ESCs_Mouse1.42945169
88P300_19829295_ChIP-Seq_ESCs_Human1.42677432
89* PU1_27457419_Chip-Seq_LIVER_Mouse1.42567985
90* KLF4_18555785_Chip-Seq_ESCs_Mouse1.42537627
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.42216385
92AR_25329375_ChIP-Seq_VCAP_Human1.41633733
93IRF1_19129219_ChIP-ChIP_H3396_Human1.41392414
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40130674
95EWS_26573619_Chip-Seq_HEK293_Human1.39869976
96STAT3_23295773_ChIP-Seq_U87_Human1.39282594
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38656202
98* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38363919
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37508448
100NANOG_19829295_ChIP-Seq_ESCs_Human1.36611764
101SOX2_19829295_ChIP-Seq_ESCs_Human1.36611764
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36047594
103TCF4_22108803_ChIP-Seq_LS180_Human1.34159767
104* ZFX_18555785_Chip-Seq_ESCs_Mouse1.34017180
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32881504
106* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32588939
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.31833457
108* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.31567876
109MYC_18940864_ChIP-ChIP_HL60_Human1.28019139
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27339289
111JUN_21703547_ChIP-Seq_K562_Human1.26236654
112SMAD4_21799915_ChIP-Seq_A2780_Human1.25774809
113* RUNX2_22187159_ChIP-Seq_PCA_Human1.25646947
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23946548
115* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23748886
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22775282
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.22011997
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21166838
119AR_20517297_ChIP-Seq_VCAP_Human1.20790251
120EST1_17652178_ChIP-ChIP_JURKAT_Human1.20660196
121NCOR_22424771_ChIP-Seq_293T_Human1.19788404
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19083228
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18872741
124* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18323966
125STAT1_17558387_ChIP-Seq_HELA_Human1.18004230
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.16531246
127* CTCF_18555785_Chip-Seq_ESCs_Mouse1.16326681
128IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15031140
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.14953792
130E2F7_22180533_ChIP-Seq_HELA_Human1.14386370
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14105831
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13520619
133ELK1_19687146_ChIP-ChIP_HELA_Human1.12512130
134KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11916543
135KDM2B_26808549_Chip-Seq_REH_Human1.10704310
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.10193493
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09654386
138TCF4_23295773_ChIP-Seq_U87_Human1.09310336
139SMAD3_21741376_ChIP-Seq_EPCs_Human1.09261021
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.08410196
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08074237
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07563142
143* CDX2_22108803_ChIP-Seq_LS180_Human1.06892556
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06083488
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05784739
146BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05670653
147ER_23166858_ChIP-Seq_MCF-7_Human1.05333182
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04192906
149HOXB7_26014856_ChIP-Seq_BT474_Human1.03901928
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03603370
151* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03063284
152FOXH1_21741376_ChIP-Seq_EPCs_Human1.00943489
153MYC_19829295_ChIP-Seq_ESCs_Human0.98764604
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98353216
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97620089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure5.78321477
2MP0002735_abnormal_chemical_nociception3.60481880
3MP0000569_abnormal_digit_pigmentation3.45240005
4MP0008004_abnormal_stomach_pH3.36179607
5MP0003011_delayed_dark_adaptation3.35436427
6MP0004742_abnormal_vestibular_system3.31942189
7MP0002163_abnormal_gland_morphology3.28519587
8MP0001502_abnormal_circadian_rhythm3.12533184
9MP0001346_abnormal_lacrimal_gland2.93936441
10MP0002876_abnormal_thyroid_physiology2.90884142
11MP0001486_abnormal_startle_reflex2.85276817
12MP0003195_calcinosis2.57904939
13MP0009840_abnormal_foam_cell2.41162906
14MP0004147_increased_porphyrin_level2.38100475
15MP0000372_irregular_coat_pigmentation2.35055583
16MP0005379_endocrine/exocrine_gland_phen2.35028710
17MP0006292_abnormal_olfactory_placode2.32045969
18MP0003787_abnormal_imprinting2.31476767
19MP0005409_darkened_coat_color2.28730875
20MP0001440_abnormal_grooming_behavior2.27734933
21MP0002102_abnormal_ear_morphology2.24308806
22MP0000383_abnormal_hair_follicle2.12324179
23MP0008875_abnormal_xenobiotic_pharmacok2.11890463
24MP0005360_urolithiasis2.11357688
25MP0004484_altered_response_of2.10850030
26MP0002734_abnormal_mechanical_nocicepti2.09036915
27MP0004859_abnormal_synaptic_plasticity1.86780876
28MP0000026_abnormal_inner_ear1.85689472
29MP0003221_abnormal_cardiomyocyte_apopto1.78121219
30MP0005084_abnormal_gallbladder_morpholo1.77944963
31MP0003878_abnormal_ear_physiology1.75540242
32MP0005377_hearing/vestibular/ear_phenot1.75540242
33MP0004185_abnormal_adipocyte_glucose1.71798966
34MP0004782_abnormal_surfactant_physiolog1.70938945
35MP0001963_abnormal_hearing_physiology1.69239549
36MP0004142_abnormal_muscle_tone1.66165885
37MP0001348_abnormal_lacrimal_gland1.65822940
38MP0002736_abnormal_nociception_after1.64626083
39MP0005165_increased_susceptibility_to1.63630340
40MP0009697_abnormal_copulation1.62947956
41MP0002638_abnormal_pupillary_reflex1.62323412
42MP0001485_abnormal_pinna_reflex1.60555127
43MP0002277_abnormal_respiratory_mucosa1.60145986
44MP0005174_abnormal_tail_pigmentation1.59953427
45MP0005085_abnormal_gallbladder_physiolo1.55835245
46MP0001986_abnormal_taste_sensitivity1.55788558
47MP0004043_abnormal_pH_regulation1.52591696
48MP0001529_abnormal_vocalization1.50486663
49MP0001727_abnormal_embryo_implantation1.47848890
50MP0005083_abnormal_biliary_tract1.47591217
51MP0006276_abnormal_autonomic_nervous1.46476658
52MP0005646_abnormal_pituitary_gland1.46428168
53MP0002067_abnormal_sensory_capabilities1.46149422
54MP0003566_abnormal_cell_adhesion1.46114469
55MP0005451_abnormal_body_composition1.45200675
56MP0003122_maternal_imprinting1.44947292
57MP0002572_abnormal_emotion/affect_behav1.41667312
58MP0003868_abnormal_feces_composition1.41457602
59MP0001501_abnormal_sleep_pattern1.39305293
60MP0003718_maternal_effect1.37061074
61MP0008789_abnormal_olfactory_epithelium1.36628809
62MP0005253_abnormal_eye_physiology1.35719507
63MP0010329_abnormal_lipoprotein_level1.35356239
64MP0005332_abnormal_amino_acid1.35129529
65MP0002733_abnormal_thermal_nociception1.34734466
66MP0003693_abnormal_embryo_hatching1.34373851
67MP0002139_abnormal_hepatobiliary_system1.33359804
68MP0003186_abnormal_redox_activity1.31856664
69MP0005551_abnormal_eye_electrophysiolog1.31835018
70MP0004133_heterotaxia1.29513483
71MP0004145_abnormal_muscle_electrophysio1.28400319
72MP0002837_dystrophic_cardiac_calcinosis1.27433984
73MP0005389_reproductive_system_phenotype1.27221619
74MP0005423_abnormal_somatic_nervous1.27020568
75MP0001984_abnormal_olfaction1.24095638
76MP0003252_abnormal_bile_duct1.23401784
77MP0001968_abnormal_touch/_nociception1.20200081
78MP0001764_abnormal_homeostasis1.19939733
79MP0002184_abnormal_innervation1.19555465
80MP0000631_abnormal_neuroendocrine_gland1.19489138
81MP0009384_cardiac_valve_regurgitation1.19425854
82MP0010678_abnormal_skin_adnexa1.19337410
83MP0000427_abnormal_hair_cycle1.19226500
84MP0003646_muscle_fatigue1.18426108
85MP0002928_abnormal_bile_duct1.18139355
86MP0001919_abnormal_reproductive_system1.17768989
87MP0002160_abnormal_reproductive_system1.16860828
88MP0003136_yellow_coat_color1.16391599
89MP0010030_abnormal_orbit_morphology1.15574582
90MP0005075_abnormal_melanosome_morpholog1.14397657
91MP0008877_abnormal_DNA_methylation1.13954068
92MP0003635_abnormal_synaptic_transmissio1.12964482
93MP0009764_decreased_sensitivity_to1.12321922
94MP0003890_abnormal_embryonic-extraembry1.12047480
95MP0003121_genomic_imprinting1.11109562
96MP0002234_abnormal_pharynx_morphology1.10502468
97MP0005535_abnormal_body_temperature1.10113597
98MP0008872_abnormal_physiological_respon1.08588675
99MP0002138_abnormal_hepatobiliary_system1.07005845
100MP0001970_abnormal_pain_threshold1.06718743
101MP0006072_abnormal_retinal_apoptosis1.03902377
102MP0002063_abnormal_learning/memory/cond1.02617472
103MP0004270_analgesia1.01411582
104MP0005195_abnormal_posterior_eye1.00280029
105MP0002272_abnormal_nervous_system0.99672526
106MP0002095_abnormal_skin_pigmentation0.99514443
107MP0005410_abnormal_fertilization0.98582237
108MP0005647_abnormal_sex_gland0.98343124
109MP0001324_abnormal_eye_pigmentation0.97193271
110MP0004885_abnormal_endolymph0.96673331
111MP0005394_taste/olfaction_phenotype0.96499150
112MP0005499_abnormal_olfactory_system0.96499150
113MP0008058_abnormal_DNA_repair0.96235830
114MP0005167_abnormal_blood-brain_barrier0.95810444
115MP0008057_abnormal_DNA_replication0.95346759
116MP0010094_abnormal_chromosome_stability0.94996607
117MP0009745_abnormal_behavioral_response0.93847093
118MP0002064_seizures0.93724286
119MP0002177_abnormal_outer_ear0.93258324
120MP0002557_abnormal_social/conspecific_i0.92715426
121MP0005367_renal/urinary_system_phenotyp0.90941349
122MP0000516_abnormal_urinary_system0.90941349
123MP0010386_abnormal_urinary_bladder0.90765289
124MP0005365_abnormal_bile_salt0.90108050
125MP0000681_abnormal_thyroid_gland0.89147704
126MP0005220_abnormal_exocrine_pancreas0.88759543
127MP0002752_abnormal_somatic_nervous0.88387227
128MP0002909_abnormal_adrenal_gland0.87528184
129MP0001905_abnormal_dopamine_level0.87410249
130MP0009379_abnormal_foot_pigmentation0.87056137
131MP0008995_early_reproductive_senescence0.86742847
132MP0002938_white_spotting0.82848143
133MP0004924_abnormal_behavior0.80273716
134MP0005386_behavior/neurological_phenoty0.80273716
135MP0002972_abnormal_cardiac_muscle0.79750980
136MP0008260_abnormal_autophagy0.79033164
137MP0002254_reproductive_system_inflammat0.79028010
138MP0000015_abnormal_ear_pigmentation0.78661194
139MP0003698_abnormal_male_reproductive0.77719515
140MP0005645_abnormal_hypothalamus_physiol0.77607292
141MP0005636_abnormal_mineral_homeostasis0.76780252
142MP0002653_abnormal_ependyma_morphology0.76020222
143MP0000579_abnormal_nail_morphology0.75259675
144MP0001177_atelectasis0.74084279
145MP0005248_abnormal_Harderian_gland0.73176219
146MP0003880_abnormal_central_pattern0.71148541
147MP0004130_abnormal_muscle_cell0.70202957
148MP0004019_abnormal_vitamin_homeostasis0.69708028
149MP0000920_abnormal_myelination0.66466661
150MP0002882_abnormal_neuron_morphology0.64887584
151MP0002089_abnormal_postnatal_growth/wei0.64019203
152MP0001188_hyperpigmentation0.63265336
153MP0009046_muscle_twitch0.62932351

Predicted human phenotypes

RankGene SetZ-score
1Mesomelia (HP:0003027)8.33031910
2Chromosomal breakage induced by crosslinking agents (HP:0003221)6.33551700
3Abnormal ciliary motility (HP:0012262)5.90260980
4Chromsome breakage (HP:0040012)5.78151271
5Elevated erythrocyte sedimentation rate (HP:0003565)5.54157481
6Septo-optic dysplasia (HP:0100842)4.47234589
7Abnormal respiratory motile cilium physiology (HP:0012261)4.29874862
8Pancreatic cysts (HP:0001737)4.17669959
9Azoospermia (HP:0000027)3.98210087
10Interstitial pulmonary disease (HP:0006530)3.90412054
11Obstructive lung disease (HP:0006536)3.89180242
12Chronic obstructive pulmonary disease (HP:0006510)3.89180242
13Akinesia (HP:0002304)3.78828805
14Abnormality of midbrain morphology (HP:0002418)3.72465702
15Molar tooth sign on MRI (HP:0002419)3.72465702
16Pancreatic fibrosis (HP:0100732)3.72132092
17J-shaped sella turcica (HP:0002680)3.70740734
18True hermaphroditism (HP:0010459)3.52821595
19Neonatal hypoglycemia (HP:0001998)3.50633873
20Febrile seizures (HP:0002373)3.45076313
21Infertility (HP:0000789)3.41154648
22Nephronophthisis (HP:0000090)3.35475707
23Type II lissencephaly (HP:0007260)3.28752748
24Broad palm (HP:0001169)3.28284156
25Abnormality of the renal cortex (HP:0011035)3.18932723
26Bony spicule pigmentary retinopathy (HP:0007737)3.15498966
27Fetal akinesia sequence (HP:0001989)3.11114462
28Chronic hepatic failure (HP:0100626)3.09443152
29Lower limb amyotrophy (HP:0007210)3.09419645
30Abolished electroretinogram (ERG) (HP:0000550)3.06018898
31Abnormality of the renal medulla (HP:0100957)3.04457877
32Attenuation of retinal blood vessels (HP:0007843)3.01662404
33Prostate neoplasm (HP:0100787)3.00844117
34Long clavicles (HP:0000890)2.98072211
35Medial flaring of the eyebrow (HP:0010747)2.97024510
36Pendular nystagmus (HP:0012043)2.94777796
37Absent/shortened dynein arms (HP:0200106)2.91960821
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.91960821
39Hyperglycinemia (HP:0002154)2.81219183
40Duplicated collecting system (HP:0000081)2.80572105
41Abnormal spermatogenesis (HP:0008669)2.80383011
42Hemiparesis (HP:0001269)2.79106409
43Aplasia of the musculature (HP:0100854)2.76715850
44Hyperventilation (HP:0002883)2.75194233
45Hypobetalipoproteinemia (HP:0003563)2.73237990
46Facial cleft (HP:0002006)2.68269827
47Congenital, generalized hypertrichosis (HP:0004540)2.67482545
48Short thorax (HP:0010306)2.63794266
49Tubular atrophy (HP:0000092)2.60903357
50Cerebellar dysplasia (HP:0007033)2.58012976
51Systemic lupus erythematosus (HP:0002725)2.55781251
52Upper limb muscle weakness (HP:0003484)2.55313300
53Absent septum pellucidum (HP:0001331)2.54691427
54Hypomagnesemia (HP:0002917)2.52236641
55Methylmalonic acidemia (HP:0002912)2.50998818
56Cystic liver disease (HP:0006706)2.50304334
57Focal motor seizures (HP:0011153)2.44754707
58Gait imbalance (HP:0002141)2.43598017
59Inability to walk (HP:0002540)2.43189892
60Median cleft lip (HP:0000161)2.41983129
61Dyschromatopsia (HP:0007641)2.41350116
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39385327
63Gaze-evoked nystagmus (HP:0000640)2.38378303
64Diminished movement (HP:0002374)2.38109554
65Congenital stationary night blindness (HP:0007642)2.36413480
66Distal lower limb amyotrophy (HP:0008944)2.34663241
67Congenital primary aphakia (HP:0007707)2.34010051
68Congenital sensorineural hearing impairment (HP:0008527)2.32909773
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.32376904
70Hypoplasia of the fovea (HP:0007750)2.32376904
71Fair hair (HP:0002286)2.31507240
72Rhizomelia (HP:0008905)2.31498986
73Hyperglycinuria (HP:0003108)2.31322302
74Thyroid-stimulating hormone excess (HP:0002925)2.29221126
75Abnormality of pyrimidine metabolism (HP:0004353)2.28785827
76Abnormality of the septum pellucidum (HP:0007375)2.28355899
77Hypohidrosis (HP:0000966)2.26357556
78Increased corneal curvature (HP:0100692)2.25771830
79Keratoconus (HP:0000563)2.25771830
80Polydipsia (HP:0001959)2.23819651
81Abnormal drinking behavior (HP:0030082)2.23819651
82Postural instability (HP:0002172)2.22370451
83Methylmalonic aciduria (HP:0012120)2.20267823
84Morphological abnormality of the inner ear (HP:0011390)2.19254647
85Abnormality of the right ventricle (HP:0001707)2.18431043
86Abnormality of the renal collecting system (HP:0004742)2.18047970
87Thyroiditis (HP:0100646)2.15496157
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15155213
89Abnormality of alanine metabolism (HP:0010916)2.15155213
90Hyperalaninemia (HP:0003348)2.15155213
91Colon cancer (HP:0003003)2.14179398
92Abnormality of glycine metabolism (HP:0010895)2.13902096
93Abnormality of serine family amino acid metabolism (HP:0010894)2.13902096
94Meckel diverticulum (HP:0002245)2.12182005
95Nephrogenic diabetes insipidus (HP:0009806)2.11837561
96Increased CSF lactate (HP:0002490)2.11429540
97Type I diabetes mellitus (HP:0100651)2.11298329
98Hypothermia (HP:0002045)2.10902171
99Lissencephaly (HP:0001339)2.10024223
100Decreased central vision (HP:0007663)2.08874115
101Abnormality of placental membranes (HP:0011409)2.08272161
102Amniotic constriction ring (HP:0009775)2.08272161
103Aplasia/Hypoplasia of the tongue (HP:0010295)2.07412330
104Sclerocornea (HP:0000647)2.06613616
1053-Methylglutaconic aciduria (HP:0003535)2.06345820
106Tubulointerstitial nephritis (HP:0001970)2.05024409
107Progressive inability to walk (HP:0002505)2.04580389
108Prolonged neonatal jaundice (HP:0006579)2.04140662
109Hyperthyroidism (HP:0000836)2.03765472
110Polyuria (HP:0000103)2.03258565
111Popliteal pterygium (HP:0009756)2.03042402
112Central scotoma (HP:0000603)2.02577907
113Ketoacidosis (HP:0001993)2.02530437
114Mitochondrial inheritance (HP:0001427)2.02382391
115Abnormality of the ileum (HP:0001549)2.02316084
116Ketosis (HP:0001946)2.01130836
117Eosinophilia (HP:0001880)2.00952765
118Acute lymphatic leukemia (HP:0006721)1.99898406
119Corneal erosion (HP:0200020)1.99896371
120Hypochromic anemia (HP:0001931)1.99022018
121Acute encephalopathy (HP:0006846)1.97766152
122Optic nerve hypoplasia (HP:0000609)1.97732152
123Genital tract atresia (HP:0001827)1.96864194
124Abnormal biliary tract physiology (HP:0012439)1.96368528
125Bile duct proliferation (HP:0001408)1.96368528
126Impaired proprioception (HP:0010831)1.95816082
127Intestinal atresia (HP:0011100)1.95588573
128Congenital hepatic fibrosis (HP:0002612)1.95575173
129Abnormal rod and cone electroretinograms (HP:0008323)1.94514385
130Pigmentary retinal degeneration (HP:0001146)1.93707584
131Abnormality of the prostate (HP:0008775)1.93656325
132Large for gestational age (HP:0001520)1.92229892
133Acute necrotizing encephalopathy (HP:0006965)1.91651428
134Vaginal atresia (HP:0000148)1.91468552
135Arteriovenous malformation (HP:0100026)1.90881210
136Distal lower limb muscle weakness (HP:0009053)1.90227811
137Abnormal respiratory epithelium morphology (HP:0012253)1.90129811
138Abnormal respiratory motile cilium morphology (HP:0005938)1.90129811
139Furrowed tongue (HP:0000221)1.89935513
140Thoracic kyphosis (HP:0002942)1.88366847
141Abnormality of the fovea (HP:0000493)1.88366802
142Myositis (HP:0100614)1.88072775
143Optic disc pallor (HP:0000543)1.86942817
144Small hand (HP:0200055)1.85526097
145Broad-based gait (HP:0002136)1.85397832
146Hypoplasia of the pons (HP:0012110)1.84898596
147Abnormality of vitamin B metabolism (HP:0004340)1.84325561
148Abnormality of the pons (HP:0007361)1.84266706
149Joint hemorrhage (HP:0005261)1.83649721
150Progressive macrocephaly (HP:0004481)1.83321709
151Stomach cancer (HP:0012126)1.83102439
152Hypoparathyroidism (HP:0000829)1.81992957
153Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81645565
154Abnormality of macular pigmentation (HP:0008002)1.79906885
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.79802591
156Abnormality of the labia minora (HP:0012880)1.77682781
157Neonatal respiratory distress (HP:0002643)1.77316351
158Absent speech (HP:0001344)1.76432030
159Fused cervical vertebrae (HP:0002949)1.76160458
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75454086
161Male pseudohermaphroditism (HP:0000037)1.74977867
162Generalized hypopigmentation of hair (HP:0011358)1.74625803
163Aplasia/Hypoplasia of the uvula (HP:0010293)1.74545084
164Hyperlipoproteinemia (HP:0010980)1.73950302
165Anencephaly (HP:0002323)1.73609996
166Postaxial foot polydactyly (HP:0001830)1.73500533
167Progressive cerebellar ataxia (HP:0002073)1.73452834
168Tachypnea (HP:0002789)1.72554719
169Occipital encephalocele (HP:0002085)1.72465003
170Bell-shaped thorax (HP:0001591)1.71955503
171Albinism (HP:0001022)1.71564554
172Parakeratosis (HP:0001036)1.71103109
173Pachygyria (HP:0001302)1.71000619
174Purpura (HP:0000979)1.70900097
175Protruding tongue (HP:0010808)1.70633875
176Pruritus (HP:0000989)1.70446441
177Abnormality of the preputium (HP:0100587)1.70387207
178Retinitis pigmentosa (HP:0000510)1.69916914
179Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69833953
180Hypoglycemic seizures (HP:0002173)1.69430400
181Intrahepatic cholestasis (HP:0001406)1.69135237
182Reticulocytopenia (HP:0001896)1.67416093
183Abnormality of the carotid arteries (HP:0005344)1.66891827
184Renal cortical cysts (HP:0000803)1.66845951
185Polycystic kidney dysplasia (HP:0000113)1.66458411
186Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66172240
187Symptomatic seizures (HP:0011145)1.65344700
188Hypoplastic heart (HP:0001961)1.63854778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK8.60260386
2FRK5.39069727
3EIF2AK33.53078064
4MAP2K73.44382803
5MAP4K23.31329194
6MAP3K42.74511394
7BCR2.67485866
8DAPK22.62370442
9NLK2.54219694
10PIK3CG2.49996830
11ACVR1B2.36116632
12NUAK12.22387201
13ZAK2.15323327
14MAP3K62.09745454
15TAOK32.08854234
16BCKDK2.05087077
17EIF2AK22.02976409
18EPHB11.98363514
19PINK11.90382074
20CDK191.89919996
21TRIM281.73993121
22TBK11.65204161
23TLK11.59070753
24STK111.56657556
25MARK11.56034953
26FGR1.55806724
27ADRBK21.51095140
28STK391.47607058
29PKN11.46197984
30OXSR11.45964622
31MAP2K41.41310788
32MKNK21.31332273
33PDK21.28245048
34PAK31.27555154
35NTRK31.24282985
36PAK61.20776429
37FGFR21.19789557
38ALK1.19681515
39ICK1.14652615
40FES1.10777334
41LMTK21.00247972
42ADRBK10.99708506
43PHKG20.97427686
44PHKG10.97427686
45JAK10.96873052
46CAMK1G0.94562569
47INSRR0.94057969
48DYRK20.94004714
49FER0.92983447
50PLK20.92467826
51CSNK1G20.92127541
52CAMKK20.91136574
53STK38L0.90039930
54DYRK30.89084841
55CDK80.86795086
56MAP3K130.85492276
57EPHA30.85053157
58YES10.84064820
59CSNK1G10.82272867
60CAMK2A0.82073370
61VRK10.82023257
62MKNK10.81523900
63PTK2B0.80649233
64MAPKAPK30.78405278
65STK30.77290247
66GRK10.76281287
67MET0.76120929
68TNK20.76103650
69WNK30.75801290
70NTRK20.75435947
71CDK50.74320110
72DDR20.73467505
73NME10.72794587
74PRKAA20.72613869
75CSNK1G30.70546846
76AKT20.70464103
77PIK3CA0.67082658
78BRSK20.67073827
79TIE10.66696886
80NEK60.64838312
81CDK90.64632613
82TGFBR10.63907839
83ERBB30.63662714
84PDK10.60921713
85PRKCI0.60421347
86MAP2K60.60159123
87MST40.60140213
88TTK0.57319037
89ATR0.56869680
90MAPK130.55444185
91TEC0.53999545
92TGFBR20.53573534
93MAPK150.53494533
94PLK30.53294427
95PDPK10.53287929
96KIT0.52960788
97PNCK0.52727089
98MAPKAPK50.52724744
99JAK30.50949090
100SIK20.49299989
101BMPR1B0.48977425
102PRKCQ0.48559749
103MARK30.47657576
104WNK40.47102972
105EPHA40.46770505
106FLT30.45493583
107CSNK1A1L0.45444009
108PRKCD0.44754255
109CAMK1D0.44623847
110STK160.43676727
111RPS6KA50.42605571
112PRKCE0.41576079
113ROCK20.41082166
114PLK10.40662101
115IKBKB0.39972212
116UHMK10.39908305
117CDK70.39143134
118IRAK10.38092604
119VRK20.37720544
120STK40.37463670
121CDC42BPA0.36675506
122CDK30.36337294
123CLK10.35866597
124TRIB30.35425266
125PRKAA10.34768680
126MUSK0.33993032
127PRKG10.33964422
128EPHB20.33824827
129TTN0.33756209
130PRKACB0.33420226
131PLK40.33277617
132MINK10.33178830
133TXK0.33172833
134CAMK40.32321803
135CSK0.31893219
136IGF1R0.31747396
137ERBB40.31415432
138KSR20.31315907
139SRC0.31275773
140DYRK1A0.30731410
141NEK20.30598961
142OBSCN0.30516798
143FGFR40.30440400
144RIPK40.30367731
145CSNK1D0.30162441
146WEE10.29485278
147CAMK2B0.29112587
148PRKCG0.28857283
149MAP2K10.28831016
150CAMK10.28627321
151ITK0.28358084
152PRKACA0.27540748
153CSNK1A10.27420729
154INSR0.27358265
155PRKCA0.27345854
156CASK0.26907691

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.72430805
2Collecting duct acid secretion_Homo sapiens_hsa049663.63938163
3One carbon pool by folate_Homo sapiens_hsa006702.81476605
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.37529630
5Nicotine addiction_Homo sapiens_hsa050332.34478111
6Propanoate metabolism_Homo sapiens_hsa006402.29047126
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.22776251
8Synaptic vesicle cycle_Homo sapiens_hsa047212.19281123
9Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.05438093
10Phagosome_Homo sapiens_hsa041452.03159937
11Retinol metabolism_Homo sapiens_hsa008302.02660172
12beta-Alanine metabolism_Homo sapiens_hsa004101.99231956
13Phototransduction_Homo sapiens_hsa047441.97461264
14Vibrio cholerae infection_Homo sapiens_hsa051101.93709737
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89920957
16Protein export_Homo sapiens_hsa030601.88889504
17Histidine metabolism_Homo sapiens_hsa003401.87977663
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84851138
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82191745
20Selenocompound metabolism_Homo sapiens_hsa004501.75826480
21Morphine addiction_Homo sapiens_hsa050321.72681882
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.71223473
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70236479
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66478981
25Ether lipid metabolism_Homo sapiens_hsa005651.64470196
26Fat digestion and absorption_Homo sapiens_hsa049751.58926028
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.57589369
28Arginine and proline metabolism_Homo sapiens_hsa003301.56190475
29Olfactory transduction_Homo sapiens_hsa047401.50635704
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48599039
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47541965
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44750787
33RNA polymerase_Homo sapiens_hsa030201.41924677
34Fanconi anemia pathway_Homo sapiens_hsa034601.34371648
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.33741973
36Regulation of autophagy_Homo sapiens_hsa041401.32559123
37Non-homologous end-joining_Homo sapiens_hsa034501.32499329
38Arachidonic acid metabolism_Homo sapiens_hsa005901.32186057
39Peroxisome_Homo sapiens_hsa041461.31349505
40Glycerolipid metabolism_Homo sapiens_hsa005611.31064713
41Salivary secretion_Homo sapiens_hsa049701.29171886
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27438456
43Complement and coagulation cascades_Homo sapiens_hsa046101.24830538
44Oxidative phosphorylation_Homo sapiens_hsa001901.24723892
45Rheumatoid arthritis_Homo sapiens_hsa053231.19126970
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18940058
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18809168
48Tryptophan metabolism_Homo sapiens_hsa003801.18451095
49Parkinsons disease_Homo sapiens_hsa050121.18075654
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17323853
51Glutamatergic synapse_Homo sapiens_hsa047241.15930107
52Linoleic acid metabolism_Homo sapiens_hsa005911.15238235
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14522282
54Butanoate metabolism_Homo sapiens_hsa006501.14031377
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13090717
56Mineral absorption_Homo sapiens_hsa049781.12726471
57Amoebiasis_Homo sapiens_hsa051461.07773941
58ABC transporters_Homo sapiens_hsa020101.05613210
59RNA degradation_Homo sapiens_hsa030181.02180667
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98710772
61Vitamin digestion and absorption_Homo sapiens_hsa049770.96734320
62Protein digestion and absorption_Homo sapiens_hsa049740.96124578
63Ovarian steroidogenesis_Homo sapiens_hsa049130.95671453
64Sulfur metabolism_Homo sapiens_hsa009200.94961637
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92741228
66Basal transcription factors_Homo sapiens_hsa030220.92288298
67Taste transduction_Homo sapiens_hsa047420.92063105
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92018597
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91895429
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88952336
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.88496357
72Cardiac muscle contraction_Homo sapiens_hsa042600.87680893
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86764368
74GABAergic synapse_Homo sapiens_hsa047270.86569734
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85835160
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82601026
77Axon guidance_Homo sapiens_hsa043600.81382756
78Small cell lung cancer_Homo sapiens_hsa052220.79686746
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79273279
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78718965
81Insulin secretion_Homo sapiens_hsa049110.74432086
82Circadian rhythm_Homo sapiens_hsa047100.74249112
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73373910
84Huntingtons disease_Homo sapiens_hsa050160.73255912
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72796130
86Osteoclast differentiation_Homo sapiens_hsa043800.72211868
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71033987
88Bile secretion_Homo sapiens_hsa049760.69165760
89Alzheimers disease_Homo sapiens_hsa050100.69049862
90Homologous recombination_Homo sapiens_hsa034400.68459006
91ECM-receptor interaction_Homo sapiens_hsa045120.66448078
92Sphingolipid metabolism_Homo sapiens_hsa006000.66024082
93Fatty acid elongation_Homo sapiens_hsa000620.65609469
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.65347469
95Purine metabolism_Homo sapiens_hsa002300.65109236
96Nitrogen metabolism_Homo sapiens_hsa009100.64915871
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64291741
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64029245
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.60745462
100Fatty acid metabolism_Homo sapiens_hsa012120.59391573
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.59216546
102Phenylalanine metabolism_Homo sapiens_hsa003600.59171553
103Choline metabolism in cancer_Homo sapiens_hsa052310.57546651
104Tyrosine metabolism_Homo sapiens_hsa003500.57442566
105HIF-1 signaling pathway_Homo sapiens_hsa040660.56593065
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.55856992
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.55316971
108Arginine biosynthesis_Homo sapiens_hsa002200.54591785
109p53 signaling pathway_Homo sapiens_hsa041150.54076600
110Circadian entrainment_Homo sapiens_hsa047130.53617331
111Steroid biosynthesis_Homo sapiens_hsa001000.52390310
112Serotonergic synapse_Homo sapiens_hsa047260.51836777
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51731498
114Fatty acid degradation_Homo sapiens_hsa000710.51533816
115Dilated cardiomyopathy_Homo sapiens_hsa054140.50159292
116Chemical carcinogenesis_Homo sapiens_hsa052040.49143267
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.48744047
118Vitamin B6 metabolism_Homo sapiens_hsa007500.47634610
119African trypanosomiasis_Homo sapiens_hsa051430.47383627
120Type II diabetes mellitus_Homo sapiens_hsa049300.46963207
121Proteasome_Homo sapiens_hsa030500.45994651
122Pyrimidine metabolism_Homo sapiens_hsa002400.45565174
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43543411
124Glutathione metabolism_Homo sapiens_hsa004800.42860858
125Renin secretion_Homo sapiens_hsa049240.41115139
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41055001
127Type I diabetes mellitus_Homo sapiens_hsa049400.40773543
128Inositol phosphate metabolism_Homo sapiens_hsa005620.39124128
129Herpes simplex infection_Homo sapiens_hsa051680.38696208
130Cholinergic synapse_Homo sapiens_hsa047250.37914757
131Staphylococcus aureus infection_Homo sapiens_hsa051500.35981633
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35844214
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35049636
134Starch and sucrose metabolism_Homo sapiens_hsa005000.34053911
135Metabolic pathways_Homo sapiens_hsa011000.34020503
136Thyroid hormone synthesis_Homo sapiens_hsa049180.33360298
137Sulfur relay system_Homo sapiens_hsa041220.32867276
138Glucagon signaling pathway_Homo sapiens_hsa049220.32581330
139Calcium signaling pathway_Homo sapiens_hsa040200.31145219
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29686439
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27179983

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