LHB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.01178248
2cilium or flagellum-dependent cell motility (GO:0001539)7.80204058
3motile cilium assembly (GO:0044458)7.68961335
4microtubule severing (GO:0051013)7.53505921
5epithelial cilium movement (GO:0003351)6.43850481
6piRNA metabolic process (GO:0034587)6.20437556
7mitotic metaphase plate congression (GO:0007080)5.99514766
8ventricular system development (GO:0021591)5.55164528
9regulation of RIG-I signaling pathway (GO:0039535)5.21180075
10regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.19613971
11axoneme assembly (GO:0035082)5.16634885
12regulation of meiosis (GO:0040020)5.12316458
13positive regulation of megakaryocyte differentiation (GO:0045654)5.10583243
14meiotic cell cycle (GO:0051321)5.08596692
15regulation of meiosis I (GO:0060631)5.07043849
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.98089642
17male meiosis (GO:0007140)4.85374824
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.82009461
19metaphase plate congression (GO:0051310)4.74548793
20regulation of female gonad development (GO:2000194)4.61101630
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.58687143
22GTP biosynthetic process (GO:0006183)4.57693293
23DNA replication initiation (GO:0006270)4.42556353
24left/right axis specification (GO:0070986)4.41035133
25regulation of exit from mitosis (GO:0007096)4.39234441
26intraciliary transport (GO:0042073)4.34206016
27female gamete generation (GO:0007292)4.33025561
28negative regulation of meiosis (GO:0045835)4.29910360
29microtubule bundle formation (GO:0001578)4.17117514
30peptidyl-arginine omega-N-methylation (GO:0035247)4.16751738
31regulation of meiotic cell cycle (GO:0051445)4.16113769
32UTP biosynthetic process (GO:0006228)4.12898963
33positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.11033887
34regulation of cilium movement (GO:0003352)4.01058857
35protein localization to chromosome, centromeric region (GO:0071459)4.00971771
36establishment of chromosome localization (GO:0051303)4.00766911
37embryonic skeletal joint morphogenesis (GO:0060272)3.89249261
38regulation of cardioblast differentiation (GO:0051890)3.88624268
39protein localization to kinetochore (GO:0034501)3.88219620
40regulation of transforming growth factor beta2 production (GO:0032909)3.84698575
41protein K6-linked ubiquitination (GO:0085020)3.84621241
42cilium organization (GO:0044782)3.84592477
43mitotic sister chromatid segregation (GO:0000070)3.83965559
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.83134126
45mitotic chromosome condensation (GO:0007076)3.81923225
46oocyte maturation (GO:0001556)3.81887863
47cilium morphogenesis (GO:0060271)3.80702099
48DNA methylation involved in gamete generation (GO:0043046)3.74980494
49histone H2A monoubiquitination (GO:0035518)3.74836128
50negative regulation of meiotic cell cycle (GO:0051447)3.73823143
51nucleoside diphosphate phosphorylation (GO:0006165)3.71903761
52chromosome organization involved in meiosis (GO:0070192)3.71576432
53synaptonemal complex organization (GO:0070193)3.69624428
54muscle organ morphogenesis (GO:0048644)3.67957673
55cilium assembly (GO:0042384)3.66918175
56rRNA methylation (GO:0031167)3.63773141
57UTP metabolic process (GO:0046051)3.62076210
58synaptonemal complex assembly (GO:0007130)3.60357253
59rRNA modification (GO:0000154)3.57113462
60negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.53480885
61negative regulation of DNA-templated transcription, elongation (GO:0032785)3.53480885
62GDP-mannose metabolic process (GO:0019673)3.52999480
63protein polyglutamylation (GO:0018095)3.51411647
64synapsis (GO:0007129)3.50957110
65DNA damage induced protein phosphorylation (GO:0006975)3.49988284
66centriole replication (GO:0007099)3.49101405
67spliceosomal tri-snRNP complex assembly (GO:0000244)3.47746485
68regulation of retinoic acid receptor signaling pathway (GO:0048385)3.45112655
69meiosis I (GO:0007127)3.43110524
70histone exchange (GO:0043486)3.42441147
71regulation of histone H3-K27 methylation (GO:0061085)3.42086096
72negative regulation of hormone biosynthetic process (GO:0032353)3.41967427
73negative regulation of hormone metabolic process (GO:0032351)3.41967427
74CENP-A containing nucleosome assembly (GO:0034080)3.40898135
75midgut development (GO:0007494)3.39396747
76chromatin remodeling at centromere (GO:0031055)3.38953370
77nuclear pore complex assembly (GO:0051292)3.37700518
78protein maturation by protein folding (GO:0022417)3.37123766
79mitotic G1 DNA damage checkpoint (GO:0031571)3.36297031
80gene silencing by RNA (GO:0031047)3.36098684
81sperm motility (GO:0030317)3.36076689
82DNA replication-independent nucleosome organization (GO:0034724)3.35434765
83DNA replication-independent nucleosome assembly (GO:0006336)3.35434765
84male meiosis I (GO:0007141)3.34852559
85attachment of spindle microtubules to kinetochore (GO:0008608)3.33642562
86meiotic nuclear division (GO:0007126)3.31786047
87histone H2B ubiquitination (GO:0033523)3.30496133
88histone H2A ubiquitination (GO:0033522)3.30370358
89DNA damage response, signal transduction resulting in transcription (GO:0042772)3.27391396
90gamete generation (GO:0007276)3.27271321
91peptidyl-arginine methylation (GO:0018216)3.27082578
92peptidyl-arginine N-methylation (GO:0035246)3.27082578
93protein localization to chromosome (GO:0034502)3.26746543
94histone arginine methylation (GO:0034969)3.25831598
95iron-sulfur cluster assembly (GO:0016226)3.24931512
96metallo-sulfur cluster assembly (GO:0031163)3.24931512
97mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.23610954
98G1 DNA damage checkpoint (GO:0044783)3.23394510
99centriole assembly (GO:0098534)3.23248896
100spermatid development (GO:0007286)3.22830305
101ribosome biogenesis (GO:0042254)3.21778560
102regulation of cardioblast proliferation (GO:0003264)3.21707738
103regulation of secondary heart field cardioblast proliferation (GO:0003266)3.21707738
104regulation of DNA methylation (GO:0044030)3.19104418
105DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.18616899
106multicellular organism reproduction (GO:0032504)3.18104956
107pyrimidine dimer repair (GO:0006290)3.18018440
108maturation of 5.8S rRNA (GO:0000460)3.16501600
109S-adenosylmethionine metabolic process (GO:0046500)3.16304450
110mitochondrial calcium ion transport (GO:0006851)3.13588848
111spermatogenesis (GO:0007283)3.12338829
112male gamete generation (GO:0048232)3.12114663
113meiotic chromosome segregation (GO:0045132)3.11102941
114positive regulation of protein depolymerization (GO:1901881)3.10989472
115folic acid metabolic process (GO:0046655)3.10928098
116chromosome segregation (GO:0007059)3.09163660
117microtubule-based movement (GO:0007018)3.08362498
118regulation of protein sumoylation (GO:0033233)3.06653780
119sister chromatid segregation (GO:0000819)3.05121753
120regulation of sister chromatid cohesion (GO:0007063)3.04376529
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03350829
122regulation of centriole replication (GO:0046599)3.00045440
123DNA strand elongation involved in DNA replication (GO:0006271)2.99164331
124COPI coating of Golgi vesicle (GO:0048205)2.99046862
125Golgi transport vesicle coating (GO:0048200)2.99046862
126DNA strand elongation (GO:0022616)2.98247195
127mitotic G1/S transition checkpoint (GO:0044819)2.97305473
128outflow tract septum morphogenesis (GO:0003148)2.96985737
129telomere maintenance via semi-conservative replication (GO:0032201)2.96130598
130establishment of nucleus localization (GO:0040023)2.95445856
131protein complex localization (GO:0031503)2.94712931
132guanosine-containing compound biosynthetic process (GO:1901070)2.94661227
133DNA synthesis involved in DNA repair (GO:0000731)2.94544340
134positive regulation of chromosome segregation (GO:0051984)2.93324857
135positive regulation of DNA-dependent DNA replication (GO:2000105)2.93222529
136regulation of spindle checkpoint (GO:0090231)2.92406160
137embryonic heart tube development (GO:0035050)2.91295541
138ventricular cardiac muscle cell development (GO:0055015)2.90927046
139nuclear pore organization (GO:0006999)2.88468754
140muscle cell fate commitment (GO:0042693)2.88324466
141pseudouridine synthesis (GO:0001522)2.86123882
142protein retention in ER lumen (GO:0006621)2.85241646
143rRNA transcription (GO:0009303)2.84657641
144outer ear morphogenesis (GO:0042473)2.84224554
145regulation of translational fidelity (GO:0006450)2.82699102
146DNA strand renaturation (GO:0000733)2.77635409
147regulation of G0 to G1 transition (GO:0070316)2.77171163
148mitochondrial DNA metabolic process (GO:0032042)2.76336170
149DNA unwinding involved in DNA replication (GO:0006268)2.73953420
150apoptotic process involved in morphogenesis (GO:0060561)2.73158186
151maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71531245
152regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69979842
153DNA replication checkpoint (GO:0000076)2.69532085
154negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67737332
155ribonucleoprotein complex biogenesis (GO:0022613)2.65228079
156positive regulation of receptor biosynthetic process (GO:0010870)2.64657378
157thyroid gland development (GO:0030878)2.64400048
158mitotic nuclear envelope disassembly (GO:0007077)2.64241737
159regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.62960960
160oxidative phosphorylation (GO:0006119)2.60504737
161activation of Rac GTPase activity (GO:0032863)2.58710506
162spliceosomal snRNP assembly (GO:0000387)2.58216730
163meiotic cell cycle process (GO:1903046)2.58126289
164embryonic viscerocranium morphogenesis (GO:0048703)2.57414980
165transcription-coupled nucleotide-excision repair (GO:0006283)2.56710885
166mRNA cleavage (GO:0006379)2.56532654
167DNA packaging (GO:0006323)2.55338917
168retinoic acid receptor signaling pathway (GO:0048384)2.53927570
169cellular protein complex localization (GO:0034629)2.53089694
170tRNA methylation (GO:0030488)2.52785227
171morphogenesis of an endothelium (GO:0003159)2.51785132
172endothelial tube morphogenesis (GO:0061154)2.51785132
173nucleotide-excision repair, DNA gap filling (GO:0006297)2.51782587
174formation of translation preinitiation complex (GO:0001731)2.51147294
175negative regulation of RNA splicing (GO:0033119)2.48459149
176histone H4-K8 acetylation (GO:0043982)2.48367402
177histone H4-K5 acetylation (GO:0043981)2.48367402
178pore complex assembly (GO:0046931)2.46268488
179cranial nerve morphogenesis (GO:0021602)2.45658388
180deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45635500
181tRNA modification (GO:0006400)2.44175061
182axonemal dynein complex assembly (GO:0070286)10.8653532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.31452189
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.99748743
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.78025031
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.75320712
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.73506996
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.81025135
7KAP1_22055183_ChIP-Seq_ESCs_Mouse3.66012032
8E2F7_22180533_ChIP-Seq_HELA_Human3.50058346
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25216670
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.06693139
11GATA1_26923725_Chip-Seq_HPCs_Mouse3.03533000
12IGF1R_20145208_ChIP-Seq_DFB_Human2.98525800
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96989969
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.65806244
15AR_21909140_ChIP-Seq_LNCAP_Human2.60872261
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59250707
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57797140
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46478698
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40568804
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33705823
21XRN2_22483619_ChIP-Seq_HELA_Human2.31904654
22* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.20243185
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17951564
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16713018
25VDR_21846776_ChIP-Seq_THP-1_Human2.10800171
26AR_21572438_ChIP-Seq_LNCaP_Human2.10718144
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09889467
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.02977069
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.99956984
30LXR_22292898_ChIP-Seq_THP-1_Human1.97527786
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.91226366
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89459364
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86396523
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85479283
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83538061
36DCP1A_22483619_ChIP-Seq_HELA_Human1.82911389
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.82139134
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.81951387
39GABP_19822575_ChIP-Seq_HepG2_Human1.80683424
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.80544562
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80491002
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.78559952
43ZNF263_19887448_ChIP-Seq_K562_Human1.78515589
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.77361183
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77119619
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.77040460
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74322251
48P68_20966046_ChIP-Seq_HELA_Human1.69108448
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.68186050
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.67963925
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62381570
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.62174706
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61981225
54RUNX1_26923725_Chip-Seq_HPCs_Mouse1.61912214
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61735070
56CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.60165286
57MYC_22102868_ChIP-Seq_BL_Human1.57274908
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57133558
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54879463
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52677101
61TTF2_22483619_ChIP-Seq_HELA_Human1.51927282
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49905770
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49062329
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47508502
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47230029
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45831647
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45650265
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45230876
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44710147
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44449058
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.42614374
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40839852
73CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39967782
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39965181
75RNF2_27304074_Chip-Seq_NSC_Mouse1.39838493
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38957630
77ERG_20517297_ChIP-Seq_VCAP_Human1.38594511
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38232635
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38174515
80KDM5A_27292631_Chip-Seq_BREAST_Human1.35830872
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.34151506
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.33112097
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32334420
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32146185
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32137014
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.30324157
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28598892
88LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28376421
89* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25808719
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25413229
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23494272
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23127660
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22815361
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.22607745
95CTCF_21964334_Chip-Seq_Bcells_Human1.22341590
96BCOR_27268052_Chip-Seq_Bcells_Human1.22114002
97* SA1_27219007_Chip-Seq_ERYTHROID_Human1.22000604
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21211054
99BCL6_27268052_Chip-Seq_Bcells_Human1.21183998
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.21062558
101* FOXP1_21924763_ChIP-Seq_HESCs_Human1.20547986
102* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20503951
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.20106362
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20058126
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19791324
106PHF8_20622854_ChIP-Seq_HELA_Human1.19024289
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17296717
108* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16750204
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16740839
110YY1_22570637_ChIP-Seq_MALME-3M_Human1.16682151
111* ATF3_27146783_Chip-Seq_COLON_Human1.15639110
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15425704
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15211969
114SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14417248
115SMC4_20622854_ChIP-Seq_HELA_Human1.14217474
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13727492
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13456071
118SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11739788
119STAT3_23295773_ChIP-Seq_U87_Human1.11491485
120ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10632171
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10571329
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10098936
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.09818356
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09642188
125CIITA_25753668_ChIP-Seq_RAJI_Human1.09282921
126NCOR1_26117541_ChIP-Seq_K562_Human1.08857946
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07893220
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07472725
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06688375
130SMRT_27268052_Chip-Seq_Bcells_Human1.06452999
131KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06447186
132GF1_26923725_Chip-Seq_HPCs_Mouse1.06268973
133MAF_26560356_Chip-Seq_TH2_Human1.05096756
134SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04909081
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04505567
136E2F1_20622854_ChIP-Seq_HELA_Human1.04396571
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.04249978
138SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03733431
139KAP1_27257070_Chip-Seq_ESCs_Mouse1.02043844
140TP53_22127205_ChIP-Seq_IMR90_Human1.01958840
141TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01130175
142CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00863322
143FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00853348
144HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00591286
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00306078
146SPI1_26923725_Chip-Seq_HPCs_Mouse1.00014475
147STAT1_17558387_ChIP-Seq_HELA_Human0.99454635
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98964607
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.98726833
150TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98486042
151FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98390871
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97853313
153TBL1_22424771_ChIP-Seq_293T_Human0.97634941
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97391451
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97295857
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96673626
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96673626
158FUS_26573619_Chip-Seq_HEK293_Human0.96523574
159FOXH1_21741376_ChIP-Seq_EPCs_Human0.95635018
160SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92188323
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.92007698
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.91046119
163EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89870757
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89167681
165* P53_21459846_ChIP-Seq_SAOS-2_Human0.89062647
166GATA3_21867929_ChIP-Seq_CD8_Mouse0.88634924
167RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87423194
168NFYA_21822215_ChIP-Seq_K562_Human0.85410085
169ESET_19884257_ChIP-Seq_ESCs_Mouse0.85275238
170OCT1_27270436_Chip-Seq_PROSTATE_Human0.80782336
171* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80586918
172CDX2_22108803_ChIP-Seq_LS180_Human0.79740689
173FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79526113
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78951508
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.78468403
176MYC_18940864_ChIP-ChIP_HL60_Human0.77063460
177GATA6_21074721_ChIP-Seq_CACO-2_Human0.76322512
178LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.76114037
179EZH2_22144423_ChIP-Seq_EOC_Human0.75960604
180STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75644816
181ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75297052
182PHF8_20622853_ChIP-Seq_HELA_Human0.74474552
183GATA3_21867929_ChIP-Seq_TH1_Mouse0.74391933
184E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73916744
185SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.73573196
186EZH2_27294783_Chip-Seq_NPCs_Mouse0.73113288
187STAT3_18555785_Chip-Seq_ESCs_Mouse0.72414588
188SMAD4_21799915_ChIP-Seq_A2780_Human0.71914522
189PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71466686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.55554007
2MP0003718_maternal_effect4.53133791
3MP0002653_abnormal_ependyma_morphology4.41605546
4MP0003646_muscle_fatigue4.37141602
5MP0005451_abnormal_body_composition4.24910607
6MP0000678_abnormal_parathyroid_gland3.88074208
7MP0002102_abnormal_ear_morphology3.66135702
8MP0008877_abnormal_DNA_methylation3.31591222
9MP0004233_abnormal_muscle_weight3.06094449
10MP0003693_abnormal_embryo_hatching3.01891908
11MP0002877_abnormal_melanocyte_morpholog3.00034600
12MP0000537_abnormal_urethra_morphology2.95051266
13MP0010094_abnormal_chromosome_stability2.87243645
14* MP0001929_abnormal_gametogenesis2.83507409
15MP0003111_abnormal_nucleus_morphology2.68951574
16MP0005410_abnormal_fertilization2.68675133
17MP0003136_yellow_coat_color2.67584815
18MP0010234_abnormal_vibrissa_follicle2.54931977
19MP0002160_abnormal_reproductive_system2.54859761
20MP0005395_other_phenotype2.36791834
21* MP0000653_abnormal_sex_gland2.27301290
22* MP0002210_abnormal_sex_determination2.24117238
23MP0008058_abnormal_DNA_repair2.20653428
24MP0000003_abnormal_adipose_tissue2.18692312
25MP0003786_premature_aging2.17422952
26MP0003077_abnormal_cell_cycle2.16777758
27MP0010368_abnormal_lymphatic_system2.13616448
28MP0002249_abnormal_larynx_morphology2.03364698
29MP0004957_abnormal_blastocyst_morpholog2.02852005
30* MP0003698_abnormal_male_reproductive1.98495789
31MP0003937_abnormal_limbs/digits/tail_de1.95833333
32* MP0003699_abnormal_female_reproductive1.95785011
33* MP0001119_abnormal_female_reproductive1.93573222
34MP0000733_abnormal_muscle_development1.88127669
35* MP0002161_abnormal_fertility/fecundity1.86259785
36MP0002928_abnormal_bile_duct1.86094136
37MP0002234_abnormal_pharynx_morphology1.85832459
38MP0006292_abnormal_olfactory_placode1.82764566
39MP0001188_hyperpigmentation1.82707781
40MP0003123_paternal_imprinting1.82144309
41MP0008007_abnormal_cellular_replicative1.80957419
42MP0004133_heterotaxia1.79952650
43MP0008260_abnormal_autophagy1.77353386
44MP0003315_abnormal_perineum_morphology1.76047850
45* MP0001145_abnormal_male_reproductive1.73748709
46MP0005058_abnormal_lysosome_morphology1.69032791
47MP0005389_reproductive_system_phenotype1.66770287
48MP0003950_abnormal_plasma_membrane1.65731729
49MP0005499_abnormal_olfactory_system1.60851226
50MP0005394_taste/olfaction_phenotype1.60851226
51MP0003705_abnormal_hypodermis_morpholog1.57309028
52MP0008932_abnormal_embryonic_tissue1.57253843
53MP0000049_abnormal_middle_ear1.56346245
54MP0000462_abnormal_digestive_system1.55544545
55MP0001873_stomach_inflammation1.53597805
56MP0000013_abnormal_adipose_tissue1.49611426
57MP0005501_abnormal_skin_physiology1.45808989
58MP0005171_absent_coat_pigmentation1.45798724
59MP0000751_myopathy1.38662987
60MP0005408_hypopigmentation1.37590148
61MP0000613_abnormal_salivary_gland1.30179136
62MP0010307_abnormal_tumor_latency1.30029501
63MP0001730_embryonic_growth_arrest1.29246038
64MP0008057_abnormal_DNA_replication1.28055691
65MP0005076_abnormal_cell_differentiation1.23437495
66MP0002085_abnormal_embryonic_tissue1.23318471
67MP0004145_abnormal_muscle_electrophysio1.23155588
68MP0005409_darkened_coat_color1.23064322
69MP0003787_abnormal_imprinting1.20241129
70MP0002084_abnormal_developmental_patter1.18565939
71MP0005670_abnormal_white_adipose1.17827194
72MP0000358_abnormal_cell_content/1.16939496
73MP0000681_abnormal_thyroid_gland1.15819868
74MP0005646_abnormal_pituitary_gland1.14378624
75MP0006035_abnormal_mitochondrial_morpho1.14033831
76MP0001346_abnormal_lacrimal_gland1.12387073
77MP0001905_abnormal_dopamine_level1.10896512
78MP0001851_eye_inflammation1.10528217
79MP0000350_abnormal_cell_proliferation1.09519598
80MP0000762_abnormal_tongue_morphology1.05230545
81MP0008995_early_reproductive_senescence1.03485871
82MP0005187_abnormal_penis_morphology1.02706539
83MP0001348_abnormal_lacrimal_gland1.01780627
84MP0009333_abnormal_splenocyte_physiolog1.00724787
85MP0003943_abnormal_hepatobiliary_system0.99015381
86MP0005257_abnormal_intraocular_pressure0.98252153
87MP0001697_abnormal_embryo_size0.96906529
88MP0005423_abnormal_somatic_nervous0.95953315
89MP0001661_extended_life_span0.94183168
90MP0000579_abnormal_nail_morphology0.93721841
91MP0002098_abnormal_vibrissa_morphology0.93485930
92MP0003890_abnormal_embryonic-extraembry0.93085509
93MP0003121_genomic_imprinting0.91510747
94MP0002168_other_aberrant_phenotype0.90740352
95MP0001764_abnormal_homeostasis0.90440171
96MP0001727_abnormal_embryo_implantation0.90017173
97MP0005375_adipose_tissue_phenotype0.89140569
98MP0002060_abnormal_skin_morphology0.88777525
99MP0004185_abnormal_adipocyte_glucose0.88572372
100MP0003942_abnormal_urinary_system0.88347586
101MP0000467_abnormal_esophagus_morphology0.84753480
102MP0001672_abnormal_embryogenesis/_devel0.84541462
103MP0005380_embryogenesis_phenotype0.84541462
104MP0003755_abnormal_palate_morphology0.83551194
105MP0005623_abnormal_meninges_morphology0.82634456
106MP0004019_abnormal_vitamin_homeostasis0.81999374
107MP0000759_abnormal_skeletal_muscle0.81017046
108MP0001502_abnormal_circadian_rhythm0.80722819
109MP0004782_abnormal_surfactant_physiolog0.79635346
110MP0002086_abnormal_extraembryonic_tissu0.79230092
111MP0009384_cardiac_valve_regurgitation0.77993603
112MP0000631_abnormal_neuroendocrine_gland0.77597875
113MP0000015_abnormal_ear_pigmentation0.76975286
114MP0005310_abnormal_salivary_gland0.76771459
115MP0006054_spinal_hemorrhage0.75758023
116MP0001270_distended_abdomen0.74585366
117MP0002697_abnormal_eye_size0.73064880
118MP0010030_abnormal_orbit_morphology0.72868447
119MP0001919_abnormal_reproductive_system0.72546289
120MP0000372_irregular_coat_pigmentation0.72295800
121MP0002638_abnormal_pupillary_reflex0.71634149
122MP0002177_abnormal_outer_ear0.70621308
123MP0003861_abnormal_nervous_system0.69863587
124MP0004197_abnormal_fetal_growth/weight/0.69407235
125MP0002089_abnormal_postnatal_growth/wei0.67032178
126MP0002282_abnormal_trachea_morphology0.66969311
127MP0005384_cellular_phenotype0.66939973
128MP0009379_abnormal_foot_pigmentation0.66440738
129MP0002116_abnormal_craniofacial_bone0.66045385
130MP0000470_abnormal_stomach_morphology0.65648287
131MP0003385_abnormal_body_wall0.65361063
132MP0002092_abnormal_eye_morphology0.64773464
133MP0001986_abnormal_taste_sensitivity0.64019107
134MP0002019_abnormal_tumor_incidence0.63862292
135MP0001529_abnormal_vocalization0.63623878
136MP0002109_abnormal_limb_morphology0.62205893
137MP0005381_digestive/alimentary_phenotyp0.61491685
138MP0002080_prenatal_lethality0.61208292
139MP0008789_abnormal_olfactory_epithelium0.59308794
140MP0000490_abnormal_crypts_of0.59275490
141MP0003936_abnormal_reproductive_system0.57339341
142MP0001915_intracranial_hemorrhage0.57224527
143MP0001849_ear_inflammation0.55242399
144MP0002127_abnormal_cardiovascular_syste0.54157035
145MP0003984_embryonic_growth_retardation0.53863582
146MP0002269_muscular_atrophy0.52440654
147MP0009250_abnormal_appendicular_skeleto0.51825476
148MP0004381_abnormal_hair_follicle0.50788866
149MP0004270_analgesia0.49724075
150MP0002088_abnormal_embryonic_growth/wei0.49237608
151MP0002332_abnormal_exercise_endurance0.49080838
152MP0002734_abnormal_mechanical_nocicepti0.47985067
153MP0000639_abnormal_adrenal_gland0.47892834
154MP0003938_abnormal_ear_development0.47215770
155MP0005621_abnormal_cell_physiology0.43010768
156MP0000313_abnormal_cell_death0.41572060
157MP0005666_abnormal_adipose_tissue0.41562945

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.68592176
2Abnormal ciliary motility (HP:0012262)8.54902245
3Rhinitis (HP:0012384)7.40915452
4Abnormal respiratory motile cilium morphology (HP:0005938)6.86791854
5Abnormal respiratory epithelium morphology (HP:0012253)6.86791854
6Chronic bronchitis (HP:0004469)6.54178952
7Dynein arm defect of respiratory motile cilia (HP:0012255)6.26625717
8Absent/shortened dynein arms (HP:0200106)6.26625717
9Supernumerary spleens (HP:0009799)4.86328765
10Occipital encephalocele (HP:0002085)4.75580419
11Bronchiectasis (HP:0002110)4.70712478
12Entropion (HP:0000621)4.52297831
13Abnormality of DNA repair (HP:0003254)4.43236713
14Pancreatic fibrosis (HP:0100732)4.39011972
15Abnormal biliary tract physiology (HP:0012439)4.34582470
16Bile duct proliferation (HP:0001408)4.34582470
17Nasal polyposis (HP:0100582)4.33628681
18Oral leukoplakia (HP:0002745)4.28178338
19Degeneration of the lateral corticospinal tracts (HP:0002314)4.27579180
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.27579180
21True hermaphroditism (HP:0010459)4.17305545
22Adrenal hypoplasia (HP:0000835)4.03928440
23Poikiloderma (HP:0001029)4.00239943
24* Infertility (HP:0000789)3.86081360
25Termporal pattern (HP:0011008)3.74108559
26Insidious onset (HP:0003587)3.74108559
27Genetic anticipation (HP:0003743)3.55635546
28Abnormality of the nasal mucosa (HP:0000433)3.54890363
29Pancreatic cysts (HP:0001737)3.40478959
30Abnormality of the fetal cardiovascular system (HP:0010948)3.35881301
31Abnormal umbilical cord blood vessels (HP:0011403)3.35881301
32Single umbilical artery (HP:0001195)3.35881301
33Truncus arteriosus (HP:0001660)3.35238254
34Asplenia (HP:0001746)3.27693429
35Abnormality of the corticospinal tract (HP:0002492)3.27124928
36Reduced subcutaneous adipose tissue (HP:0003758)3.22605894
37Cystic liver disease (HP:0006706)3.18329570
38Congenital malformation of the right heart (HP:0011723)3.10270829
39Double outlet right ventricle (HP:0001719)3.10270829
40Breech presentation (HP:0001623)3.08556189
41Preauricular pit (HP:0004467)3.02729199
42Periauricular skin pits (HP:0100277)3.02729199
43Squamous cell carcinoma (HP:0002860)3.02146594
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.97532466
45Medial flaring of the eyebrow (HP:0010747)2.95413864
46Hypoplasia of the uterus (HP:0000013)2.95301442
47Hypoplastic pelvis (HP:0008839)2.95134458
48Hypergonadotropic hypogonadism (HP:0000815)2.92680801
49Tubulointerstitial nephritis (HP:0001970)2.91274510
50Gait imbalance (HP:0002141)2.88686752
51Congenital primary aphakia (HP:0007707)2.88444780
52Bronchitis (HP:0012387)2.78850365
53Microretrognathia (HP:0000308)2.78292945
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.76522323
55Back pain (HP:0003418)2.75265318
56Selective tooth agenesis (HP:0001592)2.66620823
57Broad distal phalanx of finger (HP:0009836)2.62540321
58Abnormality of dentin (HP:0010299)2.62363019
59Testicular atrophy (HP:0000029)2.61085699
60Nephrogenic diabetes insipidus (HP:0009806)2.58819595
61Postaxial foot polydactyly (HP:0001830)2.56960580
62Abnormality of the distal phalanges of the toes (HP:0010182)2.56875556
63Sparse lateral eyebrow (HP:0005338)2.53455271
64Ragged-red muscle fibers (HP:0003200)2.52803079
65* Male infertility (HP:0003251)2.51834139
66Viral hepatitis (HP:0006562)2.48992228
67Natal tooth (HP:0000695)2.48867759
68Disinhibition (HP:0000734)2.48607242
69Abnormality of the aortic arch (HP:0012303)2.48248016
70Microvesicular hepatic steatosis (HP:0001414)2.44849229
71Poor coordination (HP:0002370)2.43524246
72Ulnar bowing (HP:0003031)2.42166968
73Micronodular cirrhosis (HP:0001413)2.37219035
74Ureteral duplication (HP:0000073)2.36864627
75Subacute progressive viral hepatitis (HP:0006572)2.35573670
76Abnormality of midbrain morphology (HP:0002418)2.33512349
77Molar tooth sign on MRI (HP:0002419)2.33512349
78Progressive muscle weakness (HP:0003323)2.32358663
79Vertebral compression fractures (HP:0002953)2.32053542
80Abnormality of the parathyroid morphology (HP:0011766)2.29701001
81Short nail (HP:0001799)2.28881862
82Urinary bladder sphincter dysfunction (HP:0002839)2.27791209
83Aplasia/hypoplasia of the uterus (HP:0008684)2.27353815
84Upper limb amyotrophy (HP:0009129)2.20083032
85Distal upper limb amyotrophy (HP:0007149)2.20083032
86Abnormality of the umbilical cord (HP:0010881)2.18596329
87Birth length less than 3rd percentile (HP:0003561)2.18238284
88Thin bony cortex (HP:0002753)2.14361903
89Papillary thyroid carcinoma (HP:0002895)2.14000986
90Acute myeloid leukemia (HP:0004808)2.13974625
91Shoulder girdle muscle weakness (HP:0003547)2.12761486
92Genital tract atresia (HP:0001827)2.09699335
93Abnormal trabecular bone morphology (HP:0100671)2.09241522
94Horseshoe kidney (HP:0000085)2.08068701
95Abnormal number of incisors (HP:0011064)2.07699377
96Broad alveolar ridges (HP:0000187)2.05819403
97Vaginal atresia (HP:0000148)2.05627114
98Trismus (HP:0000211)2.05184301
99Premature ovarian failure (HP:0008209)2.04922907
100Proximal placement of thumb (HP:0009623)2.04900704
101Achilles tendon contracture (HP:0001771)2.02601552
102Anencephaly (HP:0002323)2.02435587
103Decreased lacrimation (HP:0000633)2.01357290
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.0907175
105Deviation of the thumb (HP:0009603)1.99974401
106High anterior hairline (HP:0009890)1.99746033
107Nephroblastoma (Wilms tumor) (HP:0002667)1.99293832
108Absent thumb (HP:0009777)1.99067376
109Impaired vibration sensation in the lower limbs (HP:0002166)1.98115528
110Breast hypoplasia (HP:0003187)1.97392106
111Self-mutilation (HP:0000742)1.96379534
112Skin pits (HP:0100276)1.96146351
113Spastic diplegia (HP:0001264)1.93677999
114Pili torti (HP:0003777)1.92802008
115Elbow flexion contracture (HP:0002987)1.92505271
116Nephronophthisis (HP:0000090)1.92418907
117Reticulocytosis (HP:0001923)1.92378436
118Congenital hepatic fibrosis (HP:0002612)1.91545450
119Furrowed tongue (HP:0000221)1.90866567
120Pelvic girdle muscle weakness (HP:0003749)1.89094393
121Abnormality of permanent molar morphology (HP:0011071)1.87327122
122Abnormality of the dental root (HP:0006486)1.87327122
123Taurodontia (HP:0000679)1.87327122
124Abnormality of reticulocytes (HP:0004312)1.86739192
125Abnormal ventriculo-arterial connection (HP:0011563)1.84376017
126Transposition of the great arteries (HP:0001669)1.84376017
127Abnormal connection of the cardiac segments (HP:0011545)1.84376017
128Secondary amenorrhea (HP:0000869)1.83833176
129Sclerocornea (HP:0000647)1.83577162
130Oculomotor apraxia (HP:0000657)1.83542409
131Stridor (HP:0010307)1.81879680
132Abnormality of pyrimidine metabolism (HP:0004353)1.80825228
133Embryonal renal neoplasm (HP:0011794)1.80021523
134Preaxial hand polydactyly (HP:0001177)1.79165297
135Atelectasis (HP:0100750)1.78991639
136Embryonal neoplasm (HP:0002898)1.77963915
137Abnormal gallbladder physiology (HP:0012438)1.77277954
138Cholecystitis (HP:0001082)1.77277954
139Cholelithiasis (HP:0001081)1.77178591
140Abnormality of molar (HP:0011077)1.77169302
141Abnormality of molar morphology (HP:0011070)1.77169302
142Dry hair (HP:0011359)1.76619968
143Large eyes (HP:0001090)1.76554622
144Broad foot (HP:0001769)1.76430606
145Chronic sinusitis (HP:0011109)1.76019434
146Hyperacusis (HP:0010780)1.75543482
147Recurrent otitis media (HP:0000403)1.75319628
148Hypercortisolism (HP:0001578)1.75309103
149Reticulocytopenia (HP:0001896)1.74834122
150Abnormality of the preputium (HP:0100587)1.74364781
151Abnormality of the lower motor neuron (HP:0002366)1.74128361
152Morphological abnormality of the pyramidal tract (HP:0002062)1.73908972
153Hypokinesia (HP:0002375)1.73372291
154Premature skin wrinkling (HP:0100678)1.72598260
155Hypoparathyroidism (HP:0000829)1.72105688
156Distal lower limb amyotrophy (HP:0008944)1.70697135
157Duplicated collecting system (HP:0000081)1.69199155
158Small intestinal stenosis (HP:0012848)1.69160478
159Duodenal stenosis (HP:0100867)1.69160478
160Abnormality of the Achilles tendon (HP:0005109)1.69011333
161Abnormality of the gallbladder (HP:0005264)1.68929858
162Spontaneous abortion (HP:0005268)1.68699273
163Abnormal delivery (HP:0001787)1.68659274
164Bowel incontinence (HP:0002607)1.68171296
165Underdeveloped nasal alae (HP:0000430)1.66463291
166Cortical visual impairment (HP:0100704)1.66462534
167Abnormality of chromosome segregation (HP:0002916)1.66365268
168Rough bone trabeculation (HP:0100670)1.66285000
169Hypotelorism (HP:0000601)1.65599878
170Short thumb (HP:0009778)1.65195028
171Hepatocellular carcinoma (HP:0001402)1.64963428
172Colitis (HP:0002583)1.64392983
173Redundant skin (HP:0001582)1.63246665
174Increased nuchal translucency (HP:0010880)1.63106278
175Chromsome breakage (HP:0040012)1.61752679
176Abnormality of the dental pulp (HP:0006479)1.61578275
177* Male pseudohermaphroditism (HP:0000037)1.60884628
178Aplasia/Hypoplasia of the lens (HP:0008063)1.59836230
179Sloping forehead (HP:0000340)1.59403067
180Tubulointerstitial abnormality (HP:0001969)1.59082015
181Decreased testicular size (HP:0008734)1.57942010
182Shawl scrotum (HP:0000049)1.55786775
183Progressive external ophthalmoplegia (HP:0000590)1.55457810
184Recurrent sinusitis (HP:0011108)1.55413542
185Chromosomal breakage induced by crosslinking agents (HP:0003221)1.54253527
186Short femoral neck (HP:0100864)1.53782587
187Facial hemangioma (HP:0000329)1.50861808
188Hyperglycinuria (HP:0003108)1.49810082
189Patellar aplasia (HP:0006443)1.48708856
190Abnormality of the labia minora (HP:0012880)1.48294402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K5.38701762
2SMG14.65855331
3SRPK14.45518846
4LATS13.90391033
5LATS23.68001525
6MAPKAPK33.46252201
7BMPR23.38283615
8NME23.32486518
9MUSK3.24853345
10TRIB32.86122497
11BRAF2.80705810
12TTK2.79780457
13KSR22.79623943
14VRK22.77787367
15MOS2.72802800
16MST1R2.61889127
17MAP3K62.59722905
18TESK22.59462287
19ARAF2.59303617
20PLK42.58709043
21ERBB42.50206837
22TAF12.49156073
23STK38L2.47875379
24EPHA22.44149168
25IRAK32.22207547
26CDC72.10789046
27TAOK32.07051224
28MAP3K92.01734322
29MAPKAPK51.96033575
30RAF11.94866914
31NME11.84166439
32NEK91.82072839
33TAOK11.77015660
34PRKD31.73548099
35NEK21.71411103
36STK31.56182245
37MET1.55360051
38WEE11.54077262
39GRK11.51023478
40DYRK21.48976202
41TRPM71.44788008
42RPS6KB21.40435601
43MAPK131.39753575
44BUB11.32295497
45PNCK1.32289490
46CHEK21.27107674
47STK161.22586079
48CCNB11.21224842
49CDK81.19774039
50PLK11.17749229
51PAK61.17534142
52MAP3K131.16159566
53MAPK151.15663406
54CDC42BPA1.15385372
55STK101.08579395
56CDK61.08413710
57MELK1.06587681
58BCKDK1.04538393
59BRSK21.04012346
60CDK91.03561434
61PIM20.99252001
62KSR10.97745361
63ERN10.94332375
64AURKA0.93432648
65AKT20.93377660
66PTK60.93080489
67MAP3K100.91311406
68SIK10.91063835
69IRAK20.88643375
70STK380.88325587
71MAP3K80.84257413
72WNK40.82908648
73PINK10.77854144
74EPHB10.76844502
75CDK190.75471651
76ABL20.75035712
77BRSK10.73887469
78PRKD20.71935921
79CDK120.69387866
80MAP3K40.66065188
81PDK20.66049145
82AURKB0.65606422
83GSK3A0.64511473
84TRIM280.63148508
85PDK30.61014151
86PDK40.61014151
87TYRO30.60060780
88NLK0.57304945
89CDK11A0.57279006
90PTK2B0.56704732
91MTOR0.55959348
92BMX0.55613597
93MAP2K30.54901807
94CSNK1G10.53806363
95RPS6KA40.53064879
96SIK20.51907107
97DYRK30.50140328
98GRK50.49893492
99PLK30.47475250
100PRKAA20.47418899
101PRKAA10.44664548
102TAOK20.44286615
103MAPK110.44095873
104DAPK10.43979999
105CHEK10.43771415
106CDK180.43058559
107GRK70.42736227
108CSNK2A10.42330986
109MAP3K20.42258903
110PAK10.40504270
111DAPK30.39673561
112MAP3K30.37343012
113ATM0.35598314
114CAMK1D0.35568806
115CDK40.34383093
116CSNK2A20.34368362
117AKT30.33291600
118CDK70.33029897
119EIF2AK10.32861025
120MAP2K60.31869687
121HIPK20.31374303
122CSNK1G30.29187328
123CDK10.27052679
124MAP2K40.26584606
125CAMK2A0.26357956
126PRKCI0.25721249
127RPS6KA20.24980638
128CSNK1G20.24323463
129MAP2K70.23167747
130TESK10.23137489
131MARK20.22906139
132PRKCG0.22700595
133CDK20.21480249
134ERBB30.20735756
135BCR0.20241385
136ICK0.19773309
137CSNK1A1L0.19649071
138VRK10.19613413
139RET0.18410316
140CSNK1E0.17805875
141RPS6KA10.16734696
142NTRK20.15854030
143PAK40.14709754
144NEK10.14672483
145ATR0.12514111
146ABL10.11871501
147SGK20.10931863
148PTK20.08941908
149CDK150.08284090

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.97453234
2Vitamin B6 metabolism_Homo sapiens_hsa007505.10134310
3Cell cycle_Homo sapiens_hsa041103.84336288
4Fanconi anemia pathway_Homo sapiens_hsa034603.19424089
5Base excision repair_Homo sapiens_hsa034103.12475235
6RNA degradation_Homo sapiens_hsa030183.06853900
7DNA replication_Homo sapiens_hsa030302.81534999
8Nucleotide excision repair_Homo sapiens_hsa034202.81527472
9Basal transcription factors_Homo sapiens_hsa030222.76331826
10Circadian rhythm_Homo sapiens_hsa047102.72384287
11* Ovarian steroidogenesis_Homo sapiens_hsa049132.61548818
12Oocyte meiosis_Homo sapiens_hsa041142.34084796
13Fructose and mannose metabolism_Homo sapiens_hsa000512.30861348
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25300703
15Linoleic acid metabolism_Homo sapiens_hsa005912.23218797
16RNA polymerase_Homo sapiens_hsa030202.22100391
17Pyrimidine metabolism_Homo sapiens_hsa002402.20778214
18Mismatch repair_Homo sapiens_hsa034302.20235373
19Homologous recombination_Homo sapiens_hsa034402.18270916
20Cyanoamino acid metabolism_Homo sapiens_hsa004602.13163668
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10601501
22RNA transport_Homo sapiens_hsa030132.03422072
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.91511836
24Ether lipid metabolism_Homo sapiens_hsa005651.86713808
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84207271
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80447776
27Purine metabolism_Homo sapiens_hsa002301.69221162
28Ribosome_Homo sapiens_hsa030101.59619671
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53356876
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53192560
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.49308416
32Other glycan degradation_Homo sapiens_hsa005111.40242573
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40114988
34Hippo signaling pathway_Homo sapiens_hsa043901.38230156
35TGF-beta signaling pathway_Homo sapiens_hsa043501.35290900
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34153846
37Galactose metabolism_Homo sapiens_hsa000521.32481605
38Sulfur metabolism_Homo sapiens_hsa009201.29018506
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.28650230
40Pentose phosphate pathway_Homo sapiens_hsa000301.28490726
41Pancreatic cancer_Homo sapiens_hsa052121.28219720
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.23715820
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11158722
44Chronic myeloid leukemia_Homo sapiens_hsa052201.08872041
45* GnRH signaling pathway_Homo sapiens_hsa049121.06319300
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05525649
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03576489
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02410312
49Dorso-ventral axis formation_Homo sapiens_hsa043201.01665702
50mRNA surveillance pathway_Homo sapiens_hsa030150.99126884
51Folate biosynthesis_Homo sapiens_hsa007900.99009892
52Long-term depression_Homo sapiens_hsa047300.98701065
53p53 signaling pathway_Homo sapiens_hsa041150.97870411
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97266196
55Non-small cell lung cancer_Homo sapiens_hsa052230.96687031
56Acute myeloid leukemia_Homo sapiens_hsa052210.96671207
57N-Glycan biosynthesis_Homo sapiens_hsa005100.96402464
58Viral carcinogenesis_Homo sapiens_hsa052030.95727254
59VEGF signaling pathway_Homo sapiens_hsa043700.93055664
60Arginine biosynthesis_Homo sapiens_hsa002200.90065234
61Tight junction_Homo sapiens_hsa045300.85378311
62Glutathione metabolism_Homo sapiens_hsa004800.84169532
63Pyruvate metabolism_Homo sapiens_hsa006200.84011862
64MicroRNAs in cancer_Homo sapiens_hsa052060.79278765
65Carbon metabolism_Homo sapiens_hsa012000.78683788
66Arachidonic acid metabolism_Homo sapiens_hsa005900.77789218
67Non-homologous end-joining_Homo sapiens_hsa034500.74838834
68Lysine degradation_Homo sapiens_hsa003100.73301614
69Adherens junction_Homo sapiens_hsa045200.71791953
70Colorectal cancer_Homo sapiens_hsa052100.70642029
71Alcoholism_Homo sapiens_hsa050340.70585963
72Choline metabolism in cancer_Homo sapiens_hsa052310.67502077
73mTOR signaling pathway_Homo sapiens_hsa041500.66568734
74Huntingtons disease_Homo sapiens_hsa050160.66102201
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66035308
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65959586
77Glioma_Homo sapiens_hsa052140.64680309
78Estrogen signaling pathway_Homo sapiens_hsa049150.63734593
79Fatty acid biosynthesis_Homo sapiens_hsa000610.63226125
80Systemic lupus erythematosus_Homo sapiens_hsa053220.62691670
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62540909
82Propanoate metabolism_Homo sapiens_hsa006400.62218994
83Hedgehog signaling pathway_Homo sapiens_hsa043400.58651878
84Arginine and proline metabolism_Homo sapiens_hsa003300.58326641
85Shigellosis_Homo sapiens_hsa051310.57579470
86* Prolactin signaling pathway_Homo sapiens_hsa049170.56646817
87Small cell lung cancer_Homo sapiens_hsa052220.54305212
88Vitamin digestion and absorption_Homo sapiens_hsa049770.53745586
89Biosynthesis of amino acids_Homo sapiens_hsa012300.52389956
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52126392
91AMPK signaling pathway_Homo sapiens_hsa041520.51488016
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51311836
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49238397
94HTLV-I infection_Homo sapiens_hsa051660.47523518
95Steroid biosynthesis_Homo sapiens_hsa001000.47428787
96One carbon pool by folate_Homo sapiens_hsa006700.45042796
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44864309
98Melanoma_Homo sapiens_hsa052180.42962805
99Ras signaling pathway_Homo sapiens_hsa040140.42330637
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42155677
101Epstein-Barr virus infection_Homo sapiens_hsa051690.41669625
102Wnt signaling pathway_Homo sapiens_hsa043100.41235602
103Insulin signaling pathway_Homo sapiens_hsa049100.41021012
104Renal cell carcinoma_Homo sapiens_hsa052110.41002126
105Endometrial cancer_Homo sapiens_hsa052130.40180986
106Thyroid cancer_Homo sapiens_hsa052160.38395648
107Inositol phosphate metabolism_Homo sapiens_hsa005620.37234936
108ErbB signaling pathway_Homo sapiens_hsa040120.37167184
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36954579
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36771995
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36432421
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35507127
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34959425
114Glycerolipid metabolism_Homo sapiens_hsa005610.33653222
115Vibrio cholerae infection_Homo sapiens_hsa051100.33375331
116MAPK signaling pathway_Homo sapiens_hsa040100.32994340
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.31690949
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31422310
119FoxO signaling pathway_Homo sapiens_hsa040680.31155358
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30438612
121Glucagon signaling pathway_Homo sapiens_hsa049220.30397289
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30311640
123Sphingolipid metabolism_Homo sapiens_hsa006000.30006324
124Basal cell carcinoma_Homo sapiens_hsa052170.29796795
125Apoptosis_Homo sapiens_hsa042100.29225812
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.28080805
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27573678
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27222294
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26985678
130Spliceosome_Homo sapiens_hsa030400.26445772
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25709067
132Collecting duct acid secretion_Homo sapiens_hsa049660.25702568
133cAMP signaling pathway_Homo sapiens_hsa040240.23711274
134Notch signaling pathway_Homo sapiens_hsa043300.23635820
135Oxytocin signaling pathway_Homo sapiens_hsa049210.21149533
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.20165210
137Bladder cancer_Homo sapiens_hsa052190.20067979
138Prostate cancer_Homo sapiens_hsa052150.19939154
139Gap junction_Homo sapiens_hsa045400.19771260
140Hepatitis B_Homo sapiens_hsa051610.17801375
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17670316
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15447600
143Glutamatergic synapse_Homo sapiens_hsa047240.15370295
144Pathways in cancer_Homo sapiens_hsa052000.13167811
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09885478
146Herpes simplex infection_Homo sapiens_hsa051680.09452849
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.09020927

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