LHFPL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)5.46799486
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.91166932
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.74832061
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.67020355
5synaptic vesicle exocytosis (GO:0016079)4.65158135
6ATP synthesis coupled proton transport (GO:0015986)4.55918619
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55918619
8neurotransmitter catabolic process (GO:0042135)4.37074177
9tryptophan catabolic process (GO:0006569)4.36252290
10indole-containing compound catabolic process (GO:0042436)4.36252290
11indolalkylamine catabolic process (GO:0046218)4.36252290
12behavioral response to ethanol (GO:0048149)4.35393372
13indolalkylamine metabolic process (GO:0006586)4.34193658
14neuromuscular process controlling posture (GO:0050884)4.28262522
15behavioral response to nicotine (GO:0035095)4.23371675
16neuron cell-cell adhesion (GO:0007158)4.19283263
17vocalization behavior (GO:0071625)4.19255173
18neuronal action potential propagation (GO:0019227)4.13085165
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10913286
20dopamine biosynthetic process (GO:0042416)4.10122517
21positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.09806081
22electron transport chain (GO:0022900)4.03242694
23respiratory electron transport chain (GO:0022904)4.02940614
24catecholamine transport (GO:0051937)3.99141063
25tachykinin receptor signaling pathway (GO:0007217)3.97044986
26neurotransmitter secretion (GO:0007269)3.96495121
27kynurenine metabolic process (GO:0070189)3.91958119
28neural tube formation (GO:0001841)3.90015480
29L-fucose metabolic process (GO:0042354)3.84174042
30L-fucose catabolic process (GO:0042355)3.84174042
31fucose catabolic process (GO:0019317)3.84174042
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.82606642
33chaperone-mediated protein transport (GO:0072321)3.78136070
34piRNA metabolic process (GO:0034587)3.76333578
35regulation of synaptic vesicle exocytosis (GO:2000300)3.74568556
36ATP hydrolysis coupled proton transport (GO:0015991)3.72921112
37energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.72921112
38ketone body metabolic process (GO:1902224)3.69985603
39detection of light stimulus involved in sensory perception (GO:0050962)3.68749605
40detection of light stimulus involved in visual perception (GO:0050908)3.68749605
41tryptophan metabolic process (GO:0006568)3.66204304
42regulation of protein kinase A signaling (GO:0010738)3.65265511
43neurotransmitter transport (GO:0006836)3.65185754
44dopamine transport (GO:0015872)3.63298517
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.62476696
46cell migration in hindbrain (GO:0021535)3.62403620
47platelet dense granule organization (GO:0060155)3.57845177
48calcium-mediated signaling using intracellular calcium source (GO:0035584)3.55319922
49signal peptide processing (GO:0006465)3.53959158
50catechol-containing compound biosynthetic process (GO:0009713)3.50740543
51catecholamine biosynthetic process (GO:0042423)3.50740543
52proline transport (GO:0015824)3.46616494
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46211397
54regulation of vesicle fusion (GO:0031338)3.45922563
55protein K11-linked deubiquitination (GO:0035871)3.43746743
56dopamine metabolic process (GO:0042417)3.43741468
57protein localization to cilium (GO:0061512)3.42939134
58negative regulation of microtubule polymerization (GO:0031115)3.42057148
59* detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.41987064
60cellular ketone body metabolic process (GO:0046950)3.41494424
61photoreceptor cell maintenance (GO:0045494)3.36766140
62cornea development in camera-type eye (GO:0061303)3.35888475
63cilium or flagellum-dependent cell motility (GO:0001539)3.35857777
64regulation of neurotransmitter levels (GO:0001505)3.33773822
65synaptic vesicle maturation (GO:0016188)3.33634139
66synaptic transmission, cholinergic (GO:0007271)3.32715018
67neurotransmitter biosynthetic process (GO:0042136)3.26133425
68serotonin metabolic process (GO:0042428)3.25795526
69glutamate secretion (GO:0014047)3.24222857
70protein neddylation (GO:0045116)3.24109273
71indole-containing compound metabolic process (GO:0042430)3.23635787
72DNA deamination (GO:0045006)3.23347326
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22718548
74response to pheromone (GO:0019236)3.21969651
75neuromuscular synaptic transmission (GO:0007274)3.18180447
76regulation of glucocorticoid secretion (GO:2000849)3.17547023
77regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17136294
78regulation of synaptic vesicle transport (GO:1902803)3.17013623
79transferrin transport (GO:0033572)3.16745980
80regulation of glutamate receptor signaling pathway (GO:1900449)3.15762925
81transmission of nerve impulse (GO:0019226)3.13964971
82axoneme assembly (GO:0035082)3.12066017
83protein localization to synapse (GO:0035418)3.12035310
84reflex (GO:0060004)3.10822713
85regulation of catecholamine metabolic process (GO:0042069)3.08687820
86regulation of dopamine metabolic process (GO:0042053)3.08687820
87neuron recognition (GO:0008038)3.07448298
88epithelial cilium movement (GO:0003351)3.06456418
89DNA methylation involved in gamete generation (GO:0043046)3.05391022
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05296681
91regulation of synaptic transmission, dopaminergic (GO:0032225)3.03670589
92detection of calcium ion (GO:0005513)3.02874359
93hydrogen ion transmembrane transport (GO:1902600)3.01525886
94aggressive behavior (GO:0002118)2.99155535
95striatum development (GO:0021756)2.98984370
96primary amino compound metabolic process (GO:1901160)2.98327005
97synaptic transmission, dopaminergic (GO:0001963)2.96391725
98response to pain (GO:0048265)2.96179679
99trivalent inorganic cation transport (GO:0072512)2.96125277
100ferric iron transport (GO:0015682)2.96125277
101neuropeptide signaling pathway (GO:0007218)2.95591087
102neuronal action potential (GO:0019228)2.94885953
103mating behavior (GO:0007617)2.94655226
104regulation of glutamate secretion (GO:0014048)2.94565437
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.94466336
106positive regulation of potassium ion transmembrane transport (GO:1901381)2.94279592
107norepinephrine metabolic process (GO:0042415)2.93158357
108detection of temperature stimulus (GO:0016048)2.93061338
109cellular biogenic amine catabolic process (GO:0042402)2.92774455
110amine catabolic process (GO:0009310)2.92774455
111negative regulation of dendrite morphogenesis (GO:0050774)2.92687008
112detection of temperature stimulus involved in sensory perception (GO:0050961)2.92347179
113detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.92347179
114regulation of glucokinase activity (GO:0033131)2.90736852
115regulation of hexokinase activity (GO:1903299)2.90736852
116neuron-neuron synaptic transmission (GO:0007270)2.90605825
117cilium morphogenesis (GO:0060271)2.89330925
118positive regulation of synapse assembly (GO:0051965)2.89123458
119response to histamine (GO:0034776)2.89043260
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88468774
121regulation of neurotransmitter transport (GO:0051588)2.88271003
122mannosylation (GO:0097502)2.87518752
123regulation of neurotransmitter secretion (GO:0046928)2.87433870
124NAD biosynthetic process (GO:0009435)2.86531694
125negative regulation of mast cell activation (GO:0033004)2.85408537
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85050930
127retinal cone cell development (GO:0046549)2.83858313
128regulation of oxidative phosphorylation (GO:0002082)2.83710531
129locomotory exploration behavior (GO:0035641)2.83373959
130inner mitochondrial membrane organization (GO:0007007)2.82826255
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82691489
132gamma-aminobutyric acid signaling pathway (GO:0007214)2.82609022
133cilium movement (GO:0003341)2.82174394
134synaptic vesicle transport (GO:0048489)2.81814667
135establishment of synaptic vesicle localization (GO:0097480)2.81814667
136L-methionine salvage (GO:0071267)2.80735292
137L-methionine biosynthetic process (GO:0071265)2.80735292
138amino acid salvage (GO:0043102)2.80735292
139activation of protein kinase A activity (GO:0034199)2.80715821
140membrane depolarization during action potential (GO:0086010)2.80195659
141response to insecticide (GO:0017085)2.80150916
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79852491
143exploration behavior (GO:0035640)2.79056658
144opioid receptor signaling pathway (GO:0038003)2.78567764
145regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.78559937
146regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.78559937
147alkaloid metabolic process (GO:0009820)2.77631637
148respiratory chain complex IV assembly (GO:0008535)2.76714802
149preassembly of GPI anchor in ER membrane (GO:0016254)2.76105704
150cilium organization (GO:0044782)2.75539981
151double-strand break repair via homologous recombination (GO:0000724)2.73428608
152photoreceptor cell development (GO:0042461)2.73282029
153recombinational repair (GO:0000725)2.72727295
154gamma-aminobutyric acid transport (GO:0015812)2.71697321
155regulation of meiosis I (GO:0060631)2.69566647
156sulfation (GO:0051923)2.68973981
157cilium assembly (GO:0042384)2.67832934
158benzene-containing compound metabolic process (GO:0042537)2.66462425
159reciprocal meiotic recombination (GO:0007131)2.65315427
160reciprocal DNA recombination (GO:0035825)2.65315427
161male meiosis (GO:0007140)2.64786198
162water-soluble vitamin biosynthetic process (GO:0042364)2.62766464
163regulation of hippo signaling (GO:0035330)2.62558882
164methionine biosynthetic process (GO:0009086)2.62408459
165adaptation of signaling pathway (GO:0023058)2.62202655
166nonmotile primary cilium assembly (GO:0035058)2.61489661
167embryonic epithelial tube formation (GO:0001838)2.59750095
168cAMP catabolic process (GO:0006198)2.57972329
169protein polyglutamylation (GO:0018095)2.54955205
170rhodopsin mediated signaling pathway (GO:0016056)2.54785734
171regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54657659
172RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54421015
173kidney morphogenesis (GO:0060993)2.53888962
174replication fork processing (GO:0031297)2.53061244
175negative regulation of translation, ncRNA-mediated (GO:0040033)2.53040496
176regulation of translation, ncRNA-mediated (GO:0045974)2.53040496
177negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53040496
178regulation of cilium movement (GO:0003352)2.51503508
179phosphatidylinositol acyl-chain remodeling (GO:0036149)2.51348907
180establishment of protein localization to Golgi (GO:0072600)2.51171054
181polyol catabolic process (GO:0046174)2.50441425
182secondary metabolite biosynthetic process (GO:0044550)2.49058954
183mitochondrial respiratory chain complex I assembly (GO:0032981)2.47985033
184NADH dehydrogenase complex assembly (GO:0010257)2.47985033
185mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47985033
186DNA double-strand break processing (GO:0000729)2.45665629
187protein complex biogenesis (GO:0070271)2.45042365
188synapsis (GO:0007129)2.44364901
189eye photoreceptor cell development (GO:0042462)2.43066591
190rRNA catabolic process (GO:0016075)2.42613397
191regulation of action potential (GO:0098900)2.41666316
192regulation of neurotransmitter uptake (GO:0051580)2.40592413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63151515
2GBX2_23144817_ChIP-Seq_PC3_Human3.57011892
3TAF15_26573619_Chip-Seq_HEK293_Human3.17235265
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92354006
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.91409380
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72487038
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71692586
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.63532582
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61225325
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.54474033
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.50703934
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45965699
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42069496
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34193974
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.32562252
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29845198
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29825300
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28300371
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27631138
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27631138
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25785697
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24396764
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22270956
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19878310
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11949262
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06526971
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.01637811
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.01452957
29ZNF274_21170338_ChIP-Seq_K562_Hela1.96962306
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.95219320
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91144978
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.84423016
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82829478
34P300_19829295_ChIP-Seq_ESCs_Human1.78539985
35IGF1R_20145208_ChIP-Seq_DFB_Human1.73655977
36SMAD4_21799915_ChIP-Seq_A2780_Human1.70630210
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69743255
38CBP_20019798_ChIP-Seq_JUKART_Human1.65597001
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65597001
40VDR_22108803_ChIP-Seq_LS180_Human1.64817760
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.63891763
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63807041
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61653217
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58459983
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58059243
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53204794
47FUS_26573619_Chip-Seq_HEK293_Human1.52710393
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52595760
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.51816454
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51514221
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50552342
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50281447
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.49735764
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47857885
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47500115
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45782539
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45782539
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.45645914
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.44798196
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43711932
61RNF2_27304074_Chip-Seq_NSC_Mouse1.43527069
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43210905
63DROSHA_22980978_ChIP-Seq_HELA_Human1.41171175
64TCF4_22108803_ChIP-Seq_LS180_Human1.39932540
65TP53_22573176_ChIP-Seq_HFKS_Human1.37358181
66NANOG_19829295_ChIP-Seq_ESCs_Human1.37216406
67SOX2_19829295_ChIP-Seq_ESCs_Human1.37216406
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30545009
69IRF1_19129219_ChIP-ChIP_H3396_Human1.30388504
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.30137020
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30085606
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29098632
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28916094
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.28899792
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.27003897
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26613989
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.25888371
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25390574
79AR_21572438_ChIP-Seq_LNCaP_Human1.24486496
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23988924
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.23988924
82JUN_21703547_ChIP-Seq_K562_Human1.23971751
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23508238
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.23399171
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22460109
86AR_25329375_ChIP-Seq_VCAP_Human1.22071554
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22046344
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21718919
89CDX2_22108803_ChIP-Seq_LS180_Human1.21660832
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.20588179
91P53_22387025_ChIP-Seq_ESCs_Mouse1.19403880
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18778042
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.16384720
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14625577
95ER_23166858_ChIP-Seq_MCF-7_Human1.14055224
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12280140
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12157130
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.11943822
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.11771553
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09839084
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08529269
102STAT3_23295773_ChIP-Seq_U87_Human1.08217123
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07813243
104MYC_18940864_ChIP-ChIP_HL60_Human1.07598604
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07455687
106RUNX2_22187159_ChIP-Seq_PCA_Human1.07434495
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07028420
108SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06167777
109AR_20517297_ChIP-Seq_VCAP_Human1.05600881
110P300_18555785_Chip-Seq_ESCs_Mouse1.05479938
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05216802
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04751214
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.04139621
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03464329
115BCAT_22108803_ChIP-Seq_LS180_Human1.03273588
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03157807
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.02686498
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02489266
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02183704
120NCOR_22424771_ChIP-Seq_293T_Human1.01274732
121TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00348987
122TP53_16413492_ChIP-PET_HCT116_Human0.99655640
123AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99238443
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98962653
125REST_19997604_ChIP-ChIP_NEURONS_Mouse0.98838124
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98805448
127TCF4_23295773_ChIP-Seq_U87_Human0.97610997
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97060692
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.96982284
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96046396
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95719322
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93289882
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.93220621
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93212778
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.93159700
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91054186
137* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90117265
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89387627
139HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87953449
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.87348193
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87258933
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86718104
143EWS_26573619_Chip-Seq_HEK293_Human0.86183421
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85977016
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85740869
146TAL1_26923725_Chip-Seq_HPCs_Mouse0.83121791
147* KDM2B_26808549_Chip-Seq_REH_Human0.81455906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.04434778
2MP0002822_catalepsy4.03491584
3MP0006276_abnormal_autonomic_nervous3.98498287
4MP0003880_abnormal_central_pattern3.53202121
5MP0001529_abnormal_vocalization3.16293840
6MP0004859_abnormal_synaptic_plasticity3.08163395
7MP0001968_abnormal_touch/_nociception3.02806594
8MP0009745_abnormal_behavioral_response2.98611465
9MP0004270_analgesia2.98206662
10MP0002735_abnormal_chemical_nociception2.97157424
11MP0003136_yellow_coat_color2.96214581
12MP0003122_maternal_imprinting2.94793768
13MP0003195_calcinosis2.93491878
14MP0003635_abnormal_synaptic_transmissio2.93460323
15MP0002102_abnormal_ear_morphology2.80856436
16MP0002638_abnormal_pupillary_reflex2.64704355
17MP0010386_abnormal_urinary_bladder2.63851701
18MP0002733_abnormal_thermal_nociception2.63601485
19MP0002734_abnormal_mechanical_nocicepti2.63327857
20MP0001440_abnormal_grooming_behavior2.63096205
21MP0003646_muscle_fatigue2.61960850
22MP0002064_seizures2.61651064
23MP0001501_abnormal_sleep_pattern2.57777202
24MP0001905_abnormal_dopamine_level2.51406252
25MP0005075_abnormal_melanosome_morpholog2.49207438
26MP0009046_muscle_twitch2.47972955
27MP0002272_abnormal_nervous_system2.47664454
28MP0002572_abnormal_emotion/affect_behav2.41826266
29MP0001970_abnormal_pain_threshold2.39622270
30MP0002063_abnormal_learning/memory/cond2.32734254
31MP0002736_abnormal_nociception_after2.24442302
32MP0005645_abnormal_hypothalamus_physiol2.22414615
33MP0005174_abnormal_tail_pigmentation2.17352589
34MP0004147_increased_porphyrin_level2.13090705
35MP0004142_abnormal_muscle_tone2.12108688
36MP0005423_abnormal_somatic_nervous2.11888026
37MP0002938_white_spotting2.07025935
38MP0004858_abnormal_nervous_system2.01299187
39MP0005646_abnormal_pituitary_gland1.99152003
40MP0006292_abnormal_olfactory_placode1.98817743
41MP0004924_abnormal_behavior1.95757694
42MP0005386_behavior/neurological_phenoty1.95757694
43MP0002067_abnormal_sensory_capabilities1.93150005
44MP0002184_abnormal_innervation1.92264486
45MP0000427_abnormal_hair_cycle1.89664502
46MP0002837_dystrophic_cardiac_calcinosis1.82775926
47MP0001188_hyperpigmentation1.79646187
48MP0000015_abnormal_ear_pigmentation1.78620997
49MP0001486_abnormal_startle_reflex1.72798769
50MP0008057_abnormal_DNA_replication1.72333424
51MP0002095_abnormal_skin_pigmentation1.69814216
52MP0004043_abnormal_pH_regulation1.65757080
53MP0002163_abnormal_gland_morphology1.64864145
54MP0001986_abnormal_taste_sensitivity1.57223968
55MP0005379_endocrine/exocrine_gland_phen1.54560221
56MP0002557_abnormal_social/conspecific_i1.54337931
57MP0001502_abnormal_circadian_rhythm1.53667805
58MP0004885_abnormal_endolymph1.52066628
59MP0002928_abnormal_bile_duct1.46907810
60MP0001324_abnormal_eye_pigmentation1.46674734
61MP0008875_abnormal_xenobiotic_pharmacok1.40205993
62MP0000538_abnormal_urinary_bladder1.39328285
63MP0002909_abnormal_adrenal_gland1.39064893
64MP0002876_abnormal_thyroid_physiology1.37543594
65MP0003787_abnormal_imprinting1.36780780
66MP0005408_hypopigmentation1.36376270
67MP0002751_abnormal_autonomic_nervous1.36036649
68MP0003123_paternal_imprinting1.34594885
69MP0000371_diluted_coat_color1.34373891
70MP0008872_abnormal_physiological_respon1.31934756
71MP0003121_genomic_imprinting1.31594058
72MP0000383_abnormal_hair_follicle1.30633264
73MP0000013_abnormal_adipose_tissue1.29703525
74MP0004381_abnormal_hair_follicle1.28917336
75MP0000778_abnormal_nervous_system1.28453926
76MP0000955_abnormal_spinal_cord1.27542367
77MP0000751_myopathy1.27041674
78MP0003878_abnormal_ear_physiology1.26595607
79MP0005377_hearing/vestibular/ear_phenot1.26595607
80MP0001485_abnormal_pinna_reflex1.26357265
81MP0004133_heterotaxia1.25415814
82MP0006072_abnormal_retinal_apoptosis1.25341662
83MP0003879_abnormal_hair_cell1.23382322
84MP0004811_abnormal_neuron_physiology1.20523906
85MP0005535_abnormal_body_temperature1.18615262
86* MP0002066_abnormal_motor_capabilities/c1.15990189
87* MP0002882_abnormal_neuron_morphology1.15394978
88MP0002234_abnormal_pharynx_morphology1.14164990
89MP0003252_abnormal_bile_duct1.13576181
90MP0005084_abnormal_gallbladder_morpholo1.12942954
91MP0003011_delayed_dark_adaptation1.12278912
92MP0003950_abnormal_plasma_membrane1.11305504
93MP0001984_abnormal_olfaction1.09589355
94MP0008569_lethality_at_weaning1.08604710
95MP0003718_maternal_effect1.07442276
96MP0002653_abnormal_ependyma_morphology1.03554699
97MP0005085_abnormal_gallbladder_physiolo1.01541015
98MP0002138_abnormal_hepatobiliary_system1.00416862
99MP0005167_abnormal_blood-brain_barrier0.98635673
100MP0003329_amyloid_beta_deposits0.98403990
101MP0006035_abnormal_mitochondrial_morpho0.93619624
102MP0002160_abnormal_reproductive_system0.93414056
103MP0005195_abnormal_posterior_eye0.93084146
104MP0005389_reproductive_system_phenotype0.92540381
105* MP0002229_neurodegeneration0.91844529
106MP0002069_abnormal_eating/drinking_beha0.91610144
107MP0001764_abnormal_homeostasis0.91548577
108MP0008058_abnormal_DNA_repair0.89894281
109MP0005551_abnormal_eye_electrophysiolog0.89555966
110MP0004145_abnormal_muscle_electrophysio0.88273416
111MP0008995_early_reproductive_senescence0.88189491
112MP0000647_abnormal_sebaceous_gland0.86329869
113MP0000631_abnormal_neuroendocrine_gland0.85245245
114* MP0002752_abnormal_somatic_nervous0.84285081
115MP0005410_abnormal_fertilization0.83853298
116MP0009780_abnormal_chondrocyte_physiolo0.82433296
117MP0009379_abnormal_foot_pigmentation0.81885320
118MP0003698_abnormal_male_reproductive0.81390693
119MP0003633_abnormal_nervous_system0.81384536
120MP0004742_abnormal_vestibular_system0.79504485
121MP0004215_abnormal_myocardial_fiber0.79190628
122MP0001664_abnormal_digestion0.78966056
123MP0005391_vision/eye_phenotype0.75845351
124MP0002090_abnormal_vision0.75249086
125MP0004085_abnormal_heartbeat0.74635701
126* MP0001963_abnormal_hearing_physiology0.73319534
127MP0000747_muscle_weakness0.72505467
128MP0003631_nervous_system_phenotype0.71963444
129MP0008874_decreased_physiological_sensi0.71525722
130MP0002152_abnormal_brain_morphology0.70860906
131MP0002075_abnormal_coat/hair_pigmentati0.70606398
132MP0001929_abnormal_gametogenesis0.69866960
133MP0005409_darkened_coat_color0.69156345
134MP0005647_abnormal_sex_gland0.65344035
135MP0009697_abnormal_copulation0.64109338
136MP0006036_abnormal_mitochondrial_physio0.64029703
137MP0002693_abnormal_pancreas_physiology0.63702893
138MP0008260_abnormal_autophagy0.62047121
139MP0008877_abnormal_DNA_methylation0.61897316
140MP0005253_abnormal_eye_physiology0.59905391
141MP0000372_irregular_coat_pigmentation0.59206768
142MP0003953_abnormal_hormone_level0.58779527
143MP0003634_abnormal_glial_cell0.57880237
144MP0005499_abnormal_olfactory_system0.55353183
145MP0005394_taste/olfaction_phenotype0.55353183
146MP0000230_abnormal_systemic_arterial0.53201347
147MP0001943_abnormal_respiration0.52765293
148MP0002332_abnormal_exercise_endurance0.51321043
149MP0003959_abnormal_lean_body0.50487649
150MP0005171_absent_coat_pigmentation0.50309529
151MP0004036_abnormal_muscle_relaxation0.49361875
152MP0002127_abnormal_cardiovascular_syste0.48994577

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)6.61878609
2Focal motor seizures (HP:0011153)6.05453202
3Myokymia (HP:0002411)6.01548039
4Atonic seizures (HP:0010819)4.98791060
5Pancreatic cysts (HP:0001737)4.70334549
6Acute necrotizing encephalopathy (HP:0006965)4.69218963
7Limb dystonia (HP:0002451)4.52852419
8Abnormal mitochondria in muscle tissue (HP:0008316)4.29446171
9Abnormal hair whorl (HP:0010721)4.28539434
10Febrile seizures (HP:0002373)4.26335125
11Pancreatic fibrosis (HP:0100732)4.24499356
12Focal seizures (HP:0007359)4.23720260
13Congenital stationary night blindness (HP:0007642)4.20505517
14Progressive macrocephaly (HP:0004481)4.17081161
15True hermaphroditism (HP:0010459)4.09942973
16Visual hallucinations (HP:0002367)4.01456719
17Absence seizures (HP:0002121)4.01054332
18Molar tooth sign on MRI (HP:0002419)3.98160828
19Abnormality of midbrain morphology (HP:0002418)3.98160828
20Mitochondrial inheritance (HP:0001427)3.85632262
21Pheochromocytoma (HP:0002666)3.84385881
22Acute encephalopathy (HP:0006846)3.73142255
23Failure to thrive in infancy (HP:0001531)3.68554387
24Neuroendocrine neoplasm (HP:0100634)3.67860660
25Nephronophthisis (HP:0000090)3.65606681
26Generalized tonic-clonic seizures (HP:0002069)3.62241084
27Abnormality of the renal cortex (HP:0011035)3.57467637
28Dialeptic seizures (HP:0011146)3.55717222
29Polyphagia (HP:0002591)3.45831956
30Abnormality of the renal medulla (HP:0100957)3.39142115
31Chronic hepatic failure (HP:0100626)3.31046619
32Oligomenorrhea (HP:0000876)3.24641537
33Type II lissencephaly (HP:0007260)3.22170940
34Attenuation of retinal blood vessels (HP:0007843)3.21796635
35Poor suck (HP:0002033)3.19662562
36Increased CSF lactate (HP:0002490)3.19464244
37Hyperventilation (HP:0002883)3.16574306
38Gaze-evoked nystagmus (HP:0000640)3.11783366
39Abnormal autonomic nervous system physiology (HP:0012332)3.04629951
40Abnormality of the labia minora (HP:0012880)3.02122016
41Hepatocellular necrosis (HP:0001404)3.01207117
42Progressive cerebellar ataxia (HP:0002073)3.00504449
43Epileptic encephalopathy (HP:0200134)3.00338686
44Cystic liver disease (HP:0006706)2.95426199
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.89662016
46Hypoplasia of the fovea (HP:0007750)2.89662016
47Orthostatic hypotension (HP:0001278)2.86571568
48Hypoventilation (HP:0002791)2.86364795
49Tubular atrophy (HP:0000092)2.83232461
50Abnormality of pain sensation (HP:0010832)2.82964857
51Impaired pain sensation (HP:0007328)2.82964857
52Abnormal pupillary function (HP:0007686)2.79289055
53Genetic anticipation (HP:0003743)2.76197550
54Keratoconus (HP:0000563)2.72611964
55Increased corneal curvature (HP:0100692)2.72611964
56Progressive inability to walk (HP:0002505)2.70979029
57Abolished electroretinogram (ERG) (HP:0000550)2.70656832
58Anxiety (HP:0000739)2.68234700
59Abnormality of alanine metabolism (HP:0010916)2.67798657
60Hyperalaninemia (HP:0003348)2.67798657
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67798657
62Decreased central vision (HP:0007663)2.64316229
63Abnormal eating behavior (HP:0100738)2.62630111
64Abnormal drinking behavior (HP:0030082)2.60776909
65Polydipsia (HP:0001959)2.60776909
66Amblyopia (HP:0000646)2.58553956
67Optic disc pallor (HP:0000543)2.57665657
68Cerebellar dysplasia (HP:0007033)2.55163469
69Myotonia (HP:0002486)2.53065882
70Bile duct proliferation (HP:0001408)2.50679882
71Abnormal biliary tract physiology (HP:0012439)2.50679882
72Congenital sensorineural hearing impairment (HP:0008527)2.50582122
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.49542384
74Renal cortical cysts (HP:0000803)2.42548027
75Abnormality of the fovea (HP:0000493)2.40715807
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.40569568
77Cerebral edema (HP:0002181)2.36441683
78Gait imbalance (HP:0002141)2.33776881
79Agitation (HP:0000713)2.33167945
80Ulnar claw (HP:0001178)2.32159624
81Congenital hepatic fibrosis (HP:0002612)2.31629038
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30267867
83Action tremor (HP:0002345)2.29406876
84Fair hair (HP:0002286)2.29282910
85Esotropia (HP:0000565)2.28607585
86Pendular nystagmus (HP:0012043)2.28530154
87Sclerocornea (HP:0000647)2.27696646
88Abnormal rod and cone electroretinograms (HP:0008323)2.25615602
89Increased hepatocellular lipid droplets (HP:0006565)2.24094901
90Supranuclear gaze palsy (HP:0000605)2.22646232
91Emotional lability (HP:0000712)2.21938164
92Abnormality of macular pigmentation (HP:0008002)2.21670751
93Hepatic necrosis (HP:0002605)2.20553179
94Hyperthyroidism (HP:0000836)2.19319845
95Aplasia/Hypoplasia of the macula (HP:0008059)2.19049715
96Absent/shortened dynein arms (HP:0200106)2.18059117
97Dynein arm defect of respiratory motile cilia (HP:0012255)2.18059117
98Psychosis (HP:0000709)2.17062502
99Respiratory failure (HP:0002878)2.16443581
100Chorioretinal atrophy (HP:0000533)2.15959112
101Generalized hypopigmentation of hair (HP:0011358)2.15324507
102Large for gestational age (HP:0001520)2.14643149
103Delayed gross motor development (HP:0002194)2.14526716
104Leukodystrophy (HP:0002415)2.13345350
105Furrowed tongue (HP:0000221)2.12616249
106Truncal ataxia (HP:0002078)2.11252098
107Clumsiness (HP:0002312)2.11083409
108Intestinal atresia (HP:0011100)2.09869072
109Polyuria (HP:0000103)2.09765480
110Abnormal ciliary motility (HP:0012262)2.09469060
111Postaxial foot polydactyly (HP:0001830)2.05447367
112Anencephaly (HP:0002323)2.04228413
113Congenital primary aphakia (HP:0007707)2.03566711
114Medial flaring of the eyebrow (HP:0010747)2.03170765
115Bony spicule pigmentary retinopathy (HP:0007737)2.02895366
116Aplasia/Hypoplasia affecting the retina (HP:0008061)2.02588582
117Absent speech (HP:0001344)2.02095307
118Male pseudohermaphroditism (HP:0000037)2.00572986
119Neoplasm of the peripheral nervous system (HP:0100007)1.99895563
120Postural tremor (HP:0002174)1.99848348
121Broad-based gait (HP:0002136)1.97524632
122Abnormal respiratory motile cilium morphology (HP:0005938)1.97068524
123Abnormal respiratory epithelium morphology (HP:0012253)1.97068524
124Lissencephaly (HP:0001339)1.96966974
125Epileptiform EEG discharges (HP:0011182)1.95992423
126Lactic acidosis (HP:0003128)1.95190409
127Retinal dysplasia (HP:0007973)1.94856373
128Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94379319
129Autoamputation (HP:0001218)1.93816803
130Vaginal atresia (HP:0000148)1.93482984
131EEG with generalized epileptiform discharges (HP:0011198)1.93117788
132Abnormality of calcium-phosphate metabolism (HP:0100530)1.92428098
133Exercise intolerance (HP:0003546)1.92100227
134Widely spaced teeth (HP:0000687)1.92066778
135Depression (HP:0000716)1.90280838
136Lipid accumulation in hepatocytes (HP:0006561)1.89060944
137Menstrual irregularities (HP:0000858)1.88540511
138Insidious onset (HP:0003587)1.88166572
139Termporal pattern (HP:0011008)1.88166572
140Delusions (HP:0000746)1.87397379
141Nasal speech (HP:0001611)1.86741784
142Abnormality of the pons (HP:0007361)1.86639610
143Sleep apnea (HP:0010535)1.85977688
144Akinesia (HP:0002304)1.85451847
145Exotropia (HP:0000577)1.84536368
146Nephrogenic diabetes insipidus (HP:0009806)1.83914419
147Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83587788
148Narrow nasal bridge (HP:0000446)1.83169648
149Ankle clonus (HP:0011448)1.82673132
150Astigmatism (HP:0000483)1.82191235
151Genital tract atresia (HP:0001827)1.82076629
152Constricted visual fields (HP:0001133)1.82054119
153Decreased circulating renin level (HP:0003351)1.82035843
154Specific learning disability (HP:0001328)1.81747405
155Protruding tongue (HP:0010808)1.81573799
156Optic nerve hypoplasia (HP:0000609)1.81463461
157Congenital, generalized hypertrichosis (HP:0004540)1.81157437
158X-linked dominant inheritance (HP:0001423)1.80428899
159Diminished movement (HP:0002374)1.80344101
160Albinism (HP:0001022)1.80283822
161Concave nail (HP:0001598)1.79875719
162Renal Fanconi syndrome (HP:0001994)1.79746217
163Hypsarrhythmia (HP:0002521)1.79640333
164Hypoplasia of the pons (HP:0012110)1.79303265
165Occipital encephalocele (HP:0002085)1.78833716
166Hypercortisolism (HP:0001578)1.75976358
167Thyroiditis (HP:0100646)1.75769185
168Postaxial hand polydactyly (HP:0001162)1.75352790
169Short tibia (HP:0005736)1.75125118
170Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75096794
171Stomach cancer (HP:0012126)1.74483664
172Inability to walk (HP:0002540)1.74401501
173Poor coordination (HP:0002370)1.72631051
174Decreased muscle mass (HP:0003199)1.72609031
175Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72570346
176Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72570346
177Supernumerary spleens (HP:0009799)1.72224786
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.72045919
179Abnormality of the corticospinal tract (HP:0002492)1.71792118
180Bradykinesia (HP:0002067)1.70778592
181Dysautonomia (HP:0002459)1.70486521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.13006040
2NTRK33.99895652
3MAP3K123.94318710
4GRK73.40490135
5CASK3.00149031
6GRK52.98161245
7ARAF2.82873113
8MAP3K42.75126733
9ACVR1B2.74508048
10MAP4K22.70119859
11MAP2K72.62375741
12NTRK12.59209900
13MAP3K92.44334763
14MINK12.39309835
15PNCK2.35697806
16STK162.28604791
17MARK12.25433883
18NUAK12.24552407
19MAP2K42.18722698
20ZAK2.17907169
21MAPK132.08229308
22NME12.07132179
23GRK12.04921622
24TAOK31.87631861
25AKT31.72169422
26TSSK61.69048911
27NTRK21.65756548
28UHMK11.58352341
29MKNK21.45201125
30PLK21.42658943
31BRSK21.40832970
32TRIM281.40781726
33ADRBK21.35922531
34CSNK1G31.34811784
35ADRBK11.33589807
36WEE11.30151489
37BRAF1.28600082
38TXK1.25247907
39CSNK1G21.22184175
40STK38L1.21151450
41PRKCG1.18006042
42MAPKAPK51.17044929
43CAMK2A1.15071163
44LIMK11.14415649
45BMPR1B1.13884862
46TGFBR11.11748548
47WNK41.10109544
48PHKG21.09598488
49PHKG11.09598488
50MAP3K21.08908099
51TLK11.06680697
52CAMK2B1.04530372
53CDK51.04227050
54PTK2B1.02900149
55CAMKK21.00773343
56MUSK0.95510793
57TEC0.94682348
58PRKCE0.94273674
59ERBB30.94196951
60FGFR20.93572514
61EIF2AK30.92060490
62KSR20.90926279
63BUB10.90373402
64TIE10.88245789
65WNK10.88067582
66RPS6KA20.87081848
67TNK20.87067652
68CAMK2G0.86903720
69INSRR0.86754520
70SIK30.86681217
71MKNK10.85236730
72PIK3CA0.83841175
73DAPK10.83401278
74BCR0.83265535
75IRAK10.83252272
76PIK3CG0.82974188
77NME20.82795050
78CSNK1G10.82552118
79TNIK0.81040988
80CDK140.80716794
81CDK190.79434488
82DAPK20.78219962
83STK30.76615212
84MAP2K10.74256324
85CAMK2D0.74087130
86STK390.73565335
87MATK0.72897964
88OXSR10.72423032
89MST40.70378562
90VRK10.69009981
91WNK30.68347611
92CDK180.67161956
93LMTK20.66157577
94LATS10.65274861
95KIT0.64983846
96NLK0.64125806
97ITK0.63533858
98PAK30.63110507
99CDK150.62939259
100SGK2230.62762945
101SGK4940.62762945
102PAK60.62744424
103FES0.62692050
104FER0.61622076
105PLK30.58973991
106MYLK0.57880674
107PRKACA0.56984123
108MAP3K10.55103737
109PRKAA20.55021324
110LATS20.54566492
111CDK11A0.52917427
112CAMKK10.51911367
113DYRK1A0.51666036
114RPS6KA50.47178559
115BCKDK0.46683261
116MAP2K60.46558466
117CSNK1E0.45190775
118SGK20.45024187
119IKBKB0.44328914
120BMPR20.44254955
121RET0.44085294
122CSNK1A10.43851069
123PINK10.43253003
124EPHA40.43206765
125MAPKAPK30.42548799
126OBSCN0.42464954
127MAP3K70.42206643
128CSNK1D0.41544162
129PRKCQ0.41349359
130CSNK1A1L0.40505101
131SIK20.39439761
132CHUK0.37880751
133FLT30.37418216
134PRKCB0.36925489
135PKN10.36024123
136IRAK20.36005239
137ERBB40.35961812
138PRKCH0.35160129
139STK110.34742391
140MARK30.34617515
141CDK30.34452453
142AURKA0.34432035
143PRKG10.34240249
144PRKACG0.34214068
145PRKAA10.34199289
146PIM20.33083961
147PRKCA0.32421737
148ATM0.32019525
149CAMK10.31992594
150SYK0.31569480
151RAF10.31261136
152ERBB20.31055665
153ABL10.30867179
154DYRK20.30327706
155SGK10.29790141
156CDC42BPA0.29248732

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.43015496
2Parkinsons disease_Homo sapiens_hsa050123.75972137
3Synaptic vesicle cycle_Homo sapiens_hsa047213.56118292
4Nicotine addiction_Homo sapiens_hsa050333.39691449
5Collecting duct acid secretion_Homo sapiens_hsa049663.16884293
6Alzheimers disease_Homo sapiens_hsa050102.90400542
7Linoleic acid metabolism_Homo sapiens_hsa005912.56971173
8Nitrogen metabolism_Homo sapiens_hsa009102.53960166
9Huntingtons disease_Homo sapiens_hsa050162.52970064
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45149643
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37585277
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21381222
13GABAergic synapse_Homo sapiens_hsa047272.18160626
14Homologous recombination_Homo sapiens_hsa034402.13464901
15Serotonergic synapse_Homo sapiens_hsa047262.11467973
16Amphetamine addiction_Homo sapiens_hsa050312.11340130
17Vibrio cholerae infection_Homo sapiens_hsa051102.08366936
18Cardiac muscle contraction_Homo sapiens_hsa042602.07309492
19Dopaminergic synapse_Homo sapiens_hsa047282.02824501
20Cocaine addiction_Homo sapiens_hsa050302.02334995
21Tryptophan metabolism_Homo sapiens_hsa003802.01593945
22Taste transduction_Homo sapiens_hsa047421.98890976
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97270253
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96071730
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.93941368
26Insulin secretion_Homo sapiens_hsa049111.88406823
27Olfactory transduction_Homo sapiens_hsa047401.86525339
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82986192
29Circadian entrainment_Homo sapiens_hsa047131.82948523
30Morphine addiction_Homo sapiens_hsa050321.80031765
31Selenocompound metabolism_Homo sapiens_hsa004501.78753671
32Fanconi anemia pathway_Homo sapiens_hsa034601.71796101
33Cholinergic synapse_Homo sapiens_hsa047251.70096415
34Basal transcription factors_Homo sapiens_hsa030221.69796118
35Propanoate metabolism_Homo sapiens_hsa006401.64796036
36Long-term potentiation_Homo sapiens_hsa047201.62222236
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59680576
38Glutamatergic synapse_Homo sapiens_hsa047241.59487664
39ABC transporters_Homo sapiens_hsa020101.59382260
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56262764
41Caffeine metabolism_Homo sapiens_hsa002321.55686616
42Salivary secretion_Homo sapiens_hsa049701.50221380
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.48953151
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45817276
45Long-term depression_Homo sapiens_hsa047301.42677307
46Proteasome_Homo sapiens_hsa030501.40425051
47Chemical carcinogenesis_Homo sapiens_hsa052041.37513783
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37150090
49Phenylalanine metabolism_Homo sapiens_hsa003601.35219836
50Protein export_Homo sapiens_hsa030601.30259678
51Tyrosine metabolism_Homo sapiens_hsa003501.27641129
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.25970608
53Calcium signaling pathway_Homo sapiens_hsa040201.21720856
54Renin secretion_Homo sapiens_hsa049241.21558239
55Non-homologous end-joining_Homo sapiens_hsa034501.21094820
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19137834
57Retinol metabolism_Homo sapiens_hsa008301.18237214
58One carbon pool by folate_Homo sapiens_hsa006701.14391231
59Peroxisome_Homo sapiens_hsa041461.12671456
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09546363
61RNA degradation_Homo sapiens_hsa030181.08548174
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06564911
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05210448
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04657009
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04286482
66Asthma_Homo sapiens_hsa053101.03738641
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02845218
68Arachidonic acid metabolism_Homo sapiens_hsa005901.02824345
69Gastric acid secretion_Homo sapiens_hsa049711.01251011
70Regulation of autophagy_Homo sapiens_hsa041400.98746084
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96477870
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95916427
73Gap junction_Homo sapiens_hsa045400.94158539
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93034416
75Phototransduction_Homo sapiens_hsa047440.92038185
76Oxytocin signaling pathway_Homo sapiens_hsa049210.90723940
77GnRH signaling pathway_Homo sapiens_hsa049120.90144101
78beta-Alanine metabolism_Homo sapiens_hsa004100.86917634
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85866346
80Rheumatoid arthritis_Homo sapiens_hsa053230.82223502
81Glycerolipid metabolism_Homo sapiens_hsa005610.79598933
82Phagosome_Homo sapiens_hsa041450.73097657
83Estrogen signaling pathway_Homo sapiens_hsa049150.72373014
84Type I diabetes mellitus_Homo sapiens_hsa049400.69474520
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.68561324
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68543162
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68184351
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66521569
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65925179
90Purine metabolism_Homo sapiens_hsa002300.65115733
91Graft-versus-host disease_Homo sapiens_hsa053320.64063101
92Primary immunodeficiency_Homo sapiens_hsa053400.62844939
93Sphingolipid metabolism_Homo sapiens_hsa006000.61712922
94Sulfur metabolism_Homo sapiens_hsa009200.60536263
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60457106
96Alcoholism_Homo sapiens_hsa050340.60186244
97Pancreatic secretion_Homo sapiens_hsa049720.59765498
98Type II diabetes mellitus_Homo sapiens_hsa049300.59400611
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58595006
100Allograft rejection_Homo sapiens_hsa053300.57914578
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57541424
102Autoimmune thyroid disease_Homo sapiens_hsa053200.55789254
103cAMP signaling pathway_Homo sapiens_hsa040240.55538266
104Vitamin B6 metabolism_Homo sapiens_hsa007500.53352579
105Melanogenesis_Homo sapiens_hsa049160.52975264
106Thyroid hormone synthesis_Homo sapiens_hsa049180.51889122
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49890140
108Oocyte meiosis_Homo sapiens_hsa041140.48843138
109Axon guidance_Homo sapiens_hsa043600.48616216
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48125801
111Fatty acid elongation_Homo sapiens_hsa000620.46990661
112Histidine metabolism_Homo sapiens_hsa003400.46619912
113Butanoate metabolism_Homo sapiens_hsa006500.46355041
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45725158
115Fat digestion and absorption_Homo sapiens_hsa049750.45266306
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44935358
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44585612
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.44208610
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43756720
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43469541
121Glucagon signaling pathway_Homo sapiens_hsa049220.43337062
122Prion diseases_Homo sapiens_hsa050200.40361700
123ErbB signaling pathway_Homo sapiens_hsa040120.40220222
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40085140
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.38220076
126Ribosome_Homo sapiens_hsa030100.38101310
127Mineral absorption_Homo sapiens_hsa049780.37084896
128Fatty acid degradation_Homo sapiens_hsa000710.35228863
129Circadian rhythm_Homo sapiens_hsa047100.34698736
130Metabolic pathways_Homo sapiens_hsa011000.34134066
131Pyruvate metabolism_Homo sapiens_hsa006200.33653079
132Fatty acid biosynthesis_Homo sapiens_hsa000610.33625442
133Vitamin digestion and absorption_Homo sapiens_hsa049770.32874978
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32294583
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32251444
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.31968354
137Dorso-ventral axis formation_Homo sapiens_hsa043200.31945897
138African trypanosomiasis_Homo sapiens_hsa051430.29864075
139Dilated cardiomyopathy_Homo sapiens_hsa054140.29000774
140Steroid biosynthesis_Homo sapiens_hsa001000.28360662
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27734352
142Inositol phosphate metabolism_Homo sapiens_hsa005620.27089418
143Ether lipid metabolism_Homo sapiens_hsa005650.26223446
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24477852
145MAPK signaling pathway_Homo sapiens_hsa040100.22620253
146RNA polymerase_Homo sapiens_hsa030200.22202383
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20259422
148Insulin signaling pathway_Homo sapiens_hsa049100.20013540
149Ovarian steroidogenesis_Homo sapiens_hsa049130.19906910
150Glioma_Homo sapiens_hsa052140.18997861
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18518330
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18185998
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.16923471

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