LHX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transmission of nerve impulse (GO:0051969)9.48802417
2retinal rod cell development (GO:0046548)9.42949898
3negative regulation of cytosolic calcium ion concentration (GO:0051481)8.43654417
4retinal cone cell development (GO:0046549)6.61404329
5positive regulation of neurological system process (GO:0031646)6.43413969
6sodium ion export (GO:0071436)6.41938759
7relaxation of smooth muscle (GO:0044557)6.28815694
8positive regulation of synaptic transmission, glutamatergic (GO:0051968)6.24340509
9synaptic vesicle exocytosis (GO:0016079)6.21456895
10synaptic vesicle endocytosis (GO:0048488)6.16944059
11protein localization to synapse (GO:0035418)5.97612200
12negative regulation of translation, ncRNA-mediated (GO:0040033)5.95455478
13regulation of translation, ncRNA-mediated (GO:0045974)5.95455478
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.95455478
15G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.83458137
16sialylation (GO:0097503)5.71610393
17monoubiquitinated protein deubiquitination (GO:0035520)5.66341658
18eye photoreceptor cell development (GO:0042462)5.53156410
19innervation (GO:0060384)5.51367206
20photoreceptor cell development (GO:0042461)5.42364589
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39603989
22potassium ion homeostasis (GO:0055075)5.35464465
23cellular potassium ion homeostasis (GO:0030007)5.27921524
24negative regulation of axon extension (GO:0030517)5.27093060
25positive regulation of synapse maturation (GO:0090129)5.25507037
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.21547897
27negative regulation of fibroblast apoptotic process (GO:2000270)5.09990250
28gamma-aminobutyric acid signaling pathway (GO:0007214)5.09792788
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.85056662
30presynaptic membrane assembly (GO:0097105)4.78253964
31photoreceptor cell maintenance (GO:0045494)4.61336239
32cell communication by electrical coupling (GO:0010644)4.53272884
33cellular sodium ion homeostasis (GO:0006883)4.52593092
34pre-miRNA processing (GO:0031054)4.50383064
35postsynaptic membrane organization (GO:0001941)4.47610142
36calcium ion import (GO:0070509)4.46998001
37establishment of synaptic vesicle localization (GO:0097480)4.36618563
38synaptic vesicle transport (GO:0048489)4.36618563
39neurotransmitter-gated ion channel clustering (GO:0072578)4.29428185
40mating behavior (GO:0007617)4.27693051
41striatum development (GO:0021756)4.14764143
42synaptic vesicle maturation (GO:0016188)4.14699504
43regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11969132
44regulation of synapse maturation (GO:0090128)4.10945233
45lysine catabolic process (GO:0006554)3.97093840
46lysine metabolic process (GO:0006553)3.97093840
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.92368081
48regulation of synaptic vesicle exocytosis (GO:2000300)3.90435280
49rhodopsin mediated signaling pathway (GO:0016056)3.90351027
50atrial cardiac muscle cell action potential (GO:0086014)3.88347114
51inositol metabolic process (GO:0006020)3.87502294
52exploration behavior (GO:0035640)3.82164180
53membrane hyperpolarization (GO:0060081)3.77445706
54nuclear pore organization (GO:0006999)3.74643950
55response to inactivity (GO:0014854)3.74627028
56regulation of rhodopsin mediated signaling pathway (GO:0022400)3.72433036
57visual perception (GO:0007601)3.68832059
58positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.68285684
59presynaptic membrane organization (GO:0097090)3.68227499
60sensory perception of light stimulus (GO:0050953)3.66464940
61mechanosensory behavior (GO:0007638)3.64499194
62retinal ganglion cell axon guidance (GO:0031290)3.59468939
63retinoic acid receptor signaling pathway (GO:0048384)3.55356565
64regulation of DNA methylation (GO:0044030)3.52271279
65membrane depolarization during action potential (GO:0086010)3.50406800
66auditory behavior (GO:0031223)3.50234967
67negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.47910888
68pyrimidine nucleobase catabolic process (GO:0006208)3.45801396
69neuroblast proliferation (GO:0007405)3.45043746
70iron coordination entity transport (GO:1901678)3.43222504
71TOR signaling (GO:0031929)3.42866527
72peptidyl-threonine dephosphorylation (GO:0035970)3.41187787
73behavioral response to ethanol (GO:0048149)3.39947490
74nitric oxide mediated signal transduction (GO:0007263)3.39594044
75detection of visible light (GO:0009584)3.39280174
76negative regulation of receptor-mediated endocytosis (GO:0048261)3.38786348
77potassium ion export (GO:0071435)3.38256815
78response to histamine (GO:0034776)3.36164730
79potassium ion import (GO:0010107)3.35914483
80central nervous system projection neuron axonogenesis (GO:0021952)3.35248535
81long-term synaptic potentiation (GO:0060291)3.34588671
82synapse assembly (GO:0007416)3.32526008
83vocalization behavior (GO:0071625)3.31248780
84regulation of DNA endoreduplication (GO:0032875)3.30761441
85prepulse inhibition (GO:0060134)3.30435856
86glycolytic process (GO:0006096)3.29250961
87cell migration in hindbrain (GO:0021535)3.29173916
88DNA unwinding involved in DNA replication (GO:0006268)3.28853789
89detection of light stimulus (GO:0009583)3.27751602
90I-kappaB phosphorylation (GO:0007252)3.27426950
91negative regulation of cell cycle G2/M phase transition (GO:1902750)3.26705998
92positive regulation of gastrulation (GO:2000543)3.26676685
93protein-chromophore linkage (GO:0018298)3.26457747
94axon cargo transport (GO:0008088)3.26108810
95neurotransmitter secretion (GO:0007269)3.24978814
96mitotic sister chromatid cohesion (GO:0007064)3.24913254
97genitalia morphogenesis (GO:0035112)3.23250169
98negative regulation of axonogenesis (GO:0050771)3.23155970
99anterograde axon cargo transport (GO:0008089)3.21781697
100nuclear pore complex assembly (GO:0051292)3.19888807
101behavioral response to nicotine (GO:0035095)3.19387824
102potassium ion transmembrane transport (GO:0071805)3.18133428
103cellular potassium ion transport (GO:0071804)3.18133428
104neurofilament cytoskeleton organization (GO:0060052)3.17721183
105glucocorticoid biosynthetic process (GO:0006704)3.15209312
106regulation of voltage-gated calcium channel activity (GO:1901385)3.14655304
107regulation of synaptic vesicle transport (GO:1902803)3.14355286
108positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09658150
109telencephalon cell migration (GO:0022029)3.09388319
110phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.07743796
111response to auditory stimulus (GO:0010996)3.07380992
112peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04390346
113apical protein localization (GO:0045176)3.04040649
114spinal cord motor neuron differentiation (GO:0021522)3.03034258
115homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.02611941
116response to host (GO:0075136)3.01581307
117response to host defenses (GO:0052200)3.01581307
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01581307
119neurotransmitter transport (GO:0006836)3.01362291
120regulation of extent of cell growth (GO:0061387)3.01162520
121regulation of axon extension (GO:0030516)3.00722850
122sympathetic nervous system development (GO:0048485)2.99908827
123neuron cell-cell adhesion (GO:0007158)2.99757758
124regulation of bile acid biosynthetic process (GO:0070857)2.99688949
125response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.99671570
126regulation of receptor internalization (GO:0002090)2.98901509
127regulation of acrosome reaction (GO:0060046)2.98485310
128type B pancreatic cell development (GO:0003323)2.97734844
129cranial nerve morphogenesis (GO:0021602)2.96359411
130retina development in camera-type eye (GO:0060041)2.92949006
131regulation of synapse structural plasticity (GO:0051823)2.92942118
132establishment of vesicle localization (GO:0051650)2.92196900
133regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.89152323
134regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.89152323
135sodium ion homeostasis (GO:0055078)2.87883087
136regulation of DNA damage checkpoint (GO:2000001)2.87519648
137urinary tract smooth muscle contraction (GO:0014848)2.86015552
138cGMP biosynthetic process (GO:0006182)2.85466100
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84676944
140response to host immune response (GO:0052572)2.84676944
141potassium ion transport (GO:0006813)2.84584532
142dermatan sulfate biosynthetic process (GO:0030208)2.84516740
143male sex determination (GO:0030238)2.83691665
144regulation of neurotransmitter secretion (GO:0046928)2.83604058
145calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.83264923
146forebrain cell migration (GO:0021885)2.81360326
147cerebellar Purkinje cell differentiation (GO:0021702)2.80654346
148inner ear receptor cell development (GO:0060119)2.80389425
149sister chromatid segregation (GO:0000819)2.79708201
150negative regulation of phosphatase activity (GO:0010923)2.79516541
151protein neddylation (GO:0045116)2.77428299
152glutamate receptor signaling pathway (GO:0007215)2.75774886
153central nervous system neuron axonogenesis (GO:0021955)2.75721126
154neuromuscular process controlling balance (GO:0050885)2.75395278
155gene silencing by RNA (GO:0031047)2.74759413
156nucleobase catabolic process (GO:0046113)2.74659411
157limb bud formation (GO:0060174)2.72355441
158dendrite morphogenesis (GO:0048813)2.71679378
159prenylation (GO:0097354)2.69423920
160protein prenylation (GO:0018342)2.69423920
161DNA topological change (GO:0006265)2.67826101
162histone mRNA catabolic process (GO:0071044)2.65984962
163axonal fasciculation (GO:0007413)2.64437852
164regulation of synaptic transmission, glutamatergic (GO:0051966)2.64151535
165regulation of fibroblast apoptotic process (GO:2000269)2.61658440
166regulation of axon guidance (GO:1902667)2.59489659
167enteric nervous system development (GO:0048484)2.59282744
168positive regulation of amino acid transport (GO:0051957)2.55599576
169regulation of axon extension involved in axon guidance (GO:0048841)2.55331979
170neuron recognition (GO:0008038)2.52362376
171dermatan sulfate metabolic process (GO:0030205)2.52336730
172synaptic transmission, glutamatergic (GO:0035249)2.51623564
173paraxial mesoderm development (GO:0048339)2.51551312
174regulation of axonogenesis (GO:0050770)2.50806403
175peripheral nervous system development (GO:0007422)2.50071619
176regulation of RNA export from nucleus (GO:0046831)2.48266236
177negative regulation of dephosphorylation (GO:0035305)2.46674241
178histone H3-K4 trimethylation (GO:0080182)2.44421012
179regulation of collateral sprouting (GO:0048670)2.44194721
180non-recombinational repair (GO:0000726)2.41949360
181double-strand break repair via nonhomologous end joining (GO:0006303)2.41949360
182neuromuscular process (GO:0050905)2.41237310
183dendritic spine morphogenesis (GO:0060997)2.40985782
184microtubule anchoring (GO:0034453)2.40461736
185neuronal action potential (GO:0019228)2.40240742
186regulation of neuron projection regeneration (GO:0070570)10.9859608
187regulation of axon regeneration (GO:0048679)10.9859608
188detection of light stimulus involved in visual perception (GO:0050908)10.2221918
189detection of light stimulus involved in sensory perception (GO:0050962)10.2221918
190locomotory exploration behavior (GO:0035641)10.1012409
191response to pheromone (GO:0019236)10.0605904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.93643745
2E2F7_22180533_ChIP-Seq_HELA_Human4.42873103
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.36401254
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.13384837
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.70494419
6GBX2_23144817_ChIP-Seq_PC3_Human3.65045273
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.14940148
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04796939
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87026930
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.86146256
11TAF15_26573619_Chip-Seq_HEK293_Human2.76247323
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.74276660
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.72619467
14DROSHA_22980978_ChIP-Seq_HELA_Human2.72446402
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69425698
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.65947100
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62352907
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62336473
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.62066074
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60412732
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54103772
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47439208
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.46730424
24* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45865886
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43734468
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40891317
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39397692
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35040794
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29403900
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29403900
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.28733109
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24630038
33EWS_26573619_Chip-Seq_HEK293_Human2.20351982
34P53_22127205_ChIP-Seq_FIBROBLAST_Human2.18226537
35TP63_19390658_ChIP-ChIP_HaCaT_Human2.17646975
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.15450084
37* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13625877
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.12935338
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11404182
40CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07828882
41* REST_18959480_ChIP-ChIP_MESCs_Mouse2.02186352
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01100616
43AR_21572438_ChIP-Seq_LNCaP_Human1.97974347
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92530467
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91283459
46ZNF274_21170338_ChIP-Seq_K562_Hela1.90900813
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90367205
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89155954
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84461115
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82245724
51* RNF2_27304074_Chip-Seq_NSC_Mouse1.79792981
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78417161
53* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74297182
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70500564
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70341395
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70038350
57SMAD4_21799915_ChIP-Seq_A2780_Human1.64178167
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63345238
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.58211234
60* E2F1_21310950_ChIP-Seq_MCF-7_Human1.58168858
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.54380606
62AR_19668381_ChIP-Seq_PC3_Human1.50637543
63* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46581021
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45364058
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43334663
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42213495
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42213495
68* CBX2_27304074_Chip-Seq_ESCs_Mouse1.41781021
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40735591
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39559590
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.39013027
72* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38383239
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36758471
74* RARB_27405468_Chip-Seq_BRAIN_Mouse1.36296033
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36288313
76FUS_26573619_Chip-Seq_HEK293_Human1.36208765
77P300_19829295_ChIP-Seq_ESCs_Human1.34389472
78CBP_20019798_ChIP-Seq_JUKART_Human1.33970784
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33970784
80* RING1B_27294783_Chip-Seq_NPCs_Mouse1.32632990
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32513162
82IGF1R_20145208_ChIP-Seq_DFB_Human1.32238496
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29083228
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.28048744
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.27325295
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27121537
87* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26943106
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25957466
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.25560985
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.25474497
91* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24831969
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23181116
93* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20900448
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.19800371
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18622798
96AHR_22903824_ChIP-Seq_MCF-7_Human1.17927719
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.17651961
98AR_25329375_ChIP-Seq_VCAP_Human1.17231813
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16700114
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.15370353
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14895935
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.14884026
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14789851
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.13565810
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13347058
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12754954
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11205711
108ER_23166858_ChIP-Seq_MCF-7_Human1.10061815
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09572609
110SOX2_16153702_ChIP-ChIP_HESCs_Human1.09072484
111RXR_22108803_ChIP-Seq_LS180_Human1.08841498
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.08558550
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08250363
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08091589
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06886156
116RUNX2_22187159_ChIP-Seq_PCA_Human1.06662768
117SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06638711
118SOX9_26525672_Chip-Seq_HEART_Mouse1.05974167
119* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05801841
120EZH2_22144423_ChIP-Seq_EOC_Human1.05615617
121* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05495205
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05405234
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05302921
124ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04178976
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03869490
126TCF4_23295773_ChIP-Seq_U87_Human1.03868428
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02152461
128STAT3_23295773_ChIP-Seq_U87_Human1.00651916
129CIITA_25753668_ChIP-Seq_RAJI_Human0.98953405
130KDM2B_26808549_Chip-Seq_REH_Human0.98160294
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97389338
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.96550719
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95225818
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95219261
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95105635
136* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.95068509
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94304826
138CBP_21632823_ChIP-Seq_H3396_Human0.92724020
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92697753
140* EZH2_27294783_Chip-Seq_NPCs_Mouse0.90213164
141GF1B_26923725_Chip-Seq_HPCs_Mouse0.86659124
142TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84427941
143IRF1_19129219_ChIP-ChIP_H3396_Human0.83608238
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83147795
145HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82232013
146* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81164728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.15159436
2MP0006072_abnormal_retinal_apoptosis5.11712615
3MP0002090_abnormal_vision4.76017338
4MP0005253_abnormal_eye_physiology3.90857287
5MP0001984_abnormal_olfaction3.61724115
6MP0001502_abnormal_circadian_rhythm3.59313571
7MP0008057_abnormal_DNA_replication3.50227053
8MP0002735_abnormal_chemical_nociception3.24509655
9MP0005248_abnormal_Harderian_gland3.18461256
10MP0005195_abnormal_posterior_eye3.07382569
11MP0001346_abnormal_lacrimal_gland3.02349671
12MP0004233_abnormal_muscle_weight2.73593321
13MP0006292_abnormal_olfactory_placode2.63917345
14MP0003011_delayed_dark_adaptation2.51833398
15MP0001486_abnormal_startle_reflex2.34198605
16MP0004215_abnormal_myocardial_fiber2.32307016
17MP0005670_abnormal_white_adipose2.21062873
18MP0008007_abnormal_cellular_replicative2.20151376
19MP0003693_abnormal_embryo_hatching2.17564548
20MP0005394_taste/olfaction_phenotype2.16160130
21MP0005499_abnormal_olfactory_system2.16160130
22MP0008789_abnormal_olfactory_epithelium2.11722878
23MP0000569_abnormal_digit_pigmentation2.11062604
24MP0003950_abnormal_plasma_membrane2.06770525
25MP0003077_abnormal_cell_cycle2.05462368
26MP0010094_abnormal_chromosome_stability2.04322019
27MP0001324_abnormal_eye_pigmentation1.99328818
28MP0002332_abnormal_exercise_endurance1.98264351
29MP0005187_abnormal_penis_morphology1.97828534
30MP0005367_renal/urinary_system_phenotyp1.93662412
31MP0000516_abnormal_urinary_system1.93662412
32MP0003635_abnormal_synaptic_transmissio1.87128158
33MP0003111_abnormal_nucleus_morphology1.86761109
34MP0002752_abnormal_somatic_nervous1.86623799
35MP0003880_abnormal_central_pattern1.84551274
36MP0002229_neurodegeneration1.80344905
37MP0003137_abnormal_impulse_conducting1.79566800
38MP0010307_abnormal_tumor_latency1.75625613
39MP0002064_seizures1.74872613
40MP0002638_abnormal_pupillary_reflex1.73463549
41MP0004957_abnormal_blastocyst_morpholog1.72801068
42MP0002653_abnormal_ependyma_morphology1.71767588
43MP0005391_vision/eye_phenotype1.71535620
44MP0008058_abnormal_DNA_repair1.71278108
45MP0002184_abnormal_innervation1.66404693
46MP0002160_abnormal_reproductive_system1.66302034
47MP0004133_heterotaxia1.63117911
48MP0001986_abnormal_taste_sensitivity1.58845042
49MP0002063_abnormal_learning/memory/cond1.57671999
50MP0002009_preneoplasia1.56021553
51MP0009046_muscle_twitch1.55924711
52MP0008775_abnormal_heart_ventricle1.54101152
53MP0002396_abnormal_hematopoietic_system1.52939717
54MP0002067_abnormal_sensory_capabilities1.52174502
55MP0002272_abnormal_nervous_system1.49735075
56MP0004142_abnormal_muscle_tone1.49485501
57MP0005076_abnormal_cell_differentiation1.48968545
58MP0001188_hyperpigmentation1.47703150
59MP0002882_abnormal_neuron_morphology1.46939943
60MP0005595_abnormal_vascular_smooth1.46578064
61MP0008932_abnormal_embryonic_tissue1.46062781
62MP0010030_abnormal_orbit_morphology1.44668477
63MP0001968_abnormal_touch/_nociception1.41191932
64MP0005423_abnormal_somatic_nervous1.41003453
65MP0009745_abnormal_behavioral_response1.40008555
66MP0003315_abnormal_perineum_morphology1.37951503
67MP0003632_abnormal_nervous_system1.36244474
68MP0004145_abnormal_muscle_electrophysio1.34833606
69MP0002736_abnormal_nociception_after1.33821973
70MP0003941_abnormal_skin_development1.33242480
71MP0002234_abnormal_pharynx_morphology1.33136909
72MP0005171_absent_coat_pigmentation1.31215498
73MP0001485_abnormal_pinna_reflex1.30137463
74* MP0000631_abnormal_neuroendocrine_gland1.28233350
75MP0001879_abnormal_lymphatic_vessel1.24752001
76MP0000955_abnormal_spinal_cord1.18822461
77MP0002572_abnormal_emotion/affect_behav1.18615911
78MP0004084_abnormal_cardiac_muscle1.17795984
79MP0002734_abnormal_mechanical_nocicepti1.17205092
80MP0003567_abnormal_fetal_cardiomyocyte1.17071157
81MP0009672_abnormal_birth_weight1.15996596
82MP0003861_abnormal_nervous_system1.14876790
83* MP0004782_abnormal_surfactant_physiolog1.14872318
84MP0008569_lethality_at_weaning1.14797978
85MP0000350_abnormal_cell_proliferation1.14239558
86MP0004859_abnormal_synaptic_plasticity1.11800781
87MP0002822_catalepsy1.08037414
88MP0010368_abnormal_lymphatic_system1.07534473
89MP0002938_white_spotting1.07525120
90MP0003755_abnormal_palate_morphology1.04478974
91MP0002085_abnormal_embryonic_tissue1.03965571
92MP0005174_abnormal_tail_pigmentation1.03606143
93MP0003634_abnormal_glial_cell1.02357523
94MP0010386_abnormal_urinary_bladder1.00010141
95MP0002557_abnormal_social/conspecific_i0.98945998
96MP0001672_abnormal_embryogenesis/_devel0.95062069
97MP0005380_embryogenesis_phenotype0.95062069
98MP0002069_abnormal_eating/drinking_beha0.93603885
99MP0003942_abnormal_urinary_system0.93323900
100MP0001440_abnormal_grooming_behavior0.93291532
101MP0002089_abnormal_postnatal_growth/wei0.90678706
102MP0008877_abnormal_DNA_methylation0.89680650
103MP0004808_abnormal_hematopoietic_stem0.89429335
104MP0002909_abnormal_adrenal_gland0.89292925
105MP0005408_hypopigmentation0.88602626
106MP0000647_abnormal_sebaceous_gland0.87786833
107MP0002114_abnormal_axial_skeleton0.87639732
108MP0003935_abnormal_craniofacial_develop0.85828861
109MP0000778_abnormal_nervous_system0.85396236
110* MP0002081_perinatal_lethality0.85276790
111MP0002127_abnormal_cardiovascular_syste0.84578167
112MP0003984_embryonic_growth_retardation0.84525112
113MP0009703_decreased_birth_body0.84436050
114MP0004036_abnormal_muscle_relaxation0.84379854
115MP0003329_amyloid_beta_deposits0.84120850
116MP0004197_abnormal_fetal_growth/weight/0.83754704
117MP0004885_abnormal_endolymph0.83704267
118MP0002697_abnormal_eye_size0.82893012
119MP0002088_abnormal_embryonic_growth/wei0.82627050
120MP0001697_abnormal_embryo_size0.81327423
121* MP0002152_abnormal_brain_morphology0.81082659
122MP0002116_abnormal_craniofacial_bone0.80550559
123MP0001299_abnormal_eye_distance/0.79835387
124MP0003631_nervous_system_phenotype0.79246447
125MP0001943_abnormal_respiration0.77693574
126MP0002751_abnormal_autonomic_nervous0.77663816
127MP0009780_abnormal_chondrocyte_physiolo0.77116493
128MP0004811_abnormal_neuron_physiology0.76389891
129MP0002066_abnormal_motor_capabilities/c0.75971022
130MP0000920_abnormal_myelination0.74794148
131MP0002080_prenatal_lethality0.74122313
132MP0002233_abnormal_nose_morphology0.73930785
133MP0001661_extended_life_span0.73396479
134MP0000427_abnormal_hair_cycle0.73205723
135MP0003879_abnormal_hair_cell0.72637918
136MP0001730_embryonic_growth_arrest0.72428802
137MP0002084_abnormal_developmental_patter0.71730844
138MP0001286_abnormal_eye_development0.70340996
139MP0001501_abnormal_sleep_pattern0.68675295
140MP0005220_abnormal_exocrine_pancreas0.67903519
141MP0004085_abnormal_heartbeat0.67498682
142MP0003698_abnormal_male_reproductive0.66655998
143MP0004270_analgesia0.65754700
144MP0004924_abnormal_behavior0.65215543
145MP0005386_behavior/neurological_phenoty0.65215543
146MP0004043_abnormal_pH_regulation0.63259637
147MP0000534_abnormal_ureter_morphology0.62835759
148MP0000751_myopathy0.62458503
149MP0003633_abnormal_nervous_system0.61840402
150MP0001963_abnormal_hearing_physiology0.60770931
151MP0001970_abnormal_pain_threshold0.58483583
152MP0010769_abnormal_survival0.56169662
153MP0000013_abnormal_adipose_tissue0.55864159
154MP0003959_abnormal_lean_body0.55824385
155MP0010768_mortality/aging0.55599501
156MP0002082_postnatal_lethality0.54342303
157MP0010770_preweaning_lethality0.54342303
158MP0001177_atelectasis0.53941854
159MP0005646_abnormal_pituitary_gland0.53739054
160MP0005620_abnormal_muscle_contractility0.53698547
161MP0003890_abnormal_embryonic-extraembry0.53223842
162MP0004742_abnormal_vestibular_system0.50669469

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.87756617
2Abnormality of macular pigmentation (HP:0008002)8.58381186
3Severe visual impairment (HP:0001141)7.09968279
4Abnormal rod and cone electroretinograms (HP:0008323)7.07381541
5Scotoma (HP:0000575)6.12736920
6Decreased central vision (HP:0007663)6.04140981
7Bony spicule pigmentary retinopathy (HP:0007737)5.50935099
8Hyperventilation (HP:0002883)5.03692925
9Febrile seizures (HP:0002373)4.77352030
10Albinism (HP:0001022)4.11276618
11Abnormal pupillary function (HP:0007686)4.11069908
12Hypoplasia of the fovea (HP:0007750)4.00525933
13Aplasia/Hypoplasia of the fovea (HP:0008060)4.00525933
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.93481420
15Attenuation of retinal blood vessels (HP:0007843)3.81961949
16Pendular nystagmus (HP:0012043)3.78325980
17Epileptic encephalopathy (HP:0200134)3.74969790
18Nephroblastoma (Wilms tumor) (HP:0002667)3.74801267
19Abnormality of the fovea (HP:0000493)3.63320565
20Dyschromatopsia (HP:0007641)3.57979869
21Increased corneal curvature (HP:0100692)3.55083666
22Keratoconus (HP:0000563)3.55083666
23Embryonal renal neoplasm (HP:0011794)3.44315952
24Stomach cancer (HP:0012126)3.42873317
25Large earlobe (HP:0009748)3.37347744
26Visual hallucinations (HP:0002367)3.36675077
27Absence seizures (HP:0002121)3.30648889
28Abnormality of the fetal cardiovascular system (HP:0010948)3.29133648
29Abnormal umbilical cord blood vessels (HP:0011403)3.29133648
30Single umbilical artery (HP:0001195)3.29133648
31Protruding tongue (HP:0010808)3.22108789
32Subacute progressive viral hepatitis (HP:0006572)3.21323142
33Abnormal gallbladder physiology (HP:0012438)3.12643113
34Cholecystitis (HP:0001082)3.12643113
35Megalencephaly (HP:0001355)3.09181644
36Aplasia/Hypoplasia of the macula (HP:0008059)3.07021384
37Broad-based gait (HP:0002136)3.02070643
38Cone-rod dystrophy (HP:0000548)3.02042776
39Spastic diplegia (HP:0001264)2.99529217
40Birth length less than 3rd percentile (HP:0003561)2.99501299
41Progressive cerebellar ataxia (HP:0002073)2.92927509
42Mutism (HP:0002300)2.90398474
43Cerebellar dysplasia (HP:0007033)2.88132462
44Abolished electroretinogram (ERG) (HP:0000550)2.86519524
45Intestinal atresia (HP:0011100)2.85654363
46Overgrowth (HP:0001548)2.82684163
47Amblyopia (HP:0000646)2.80234508
48Photophobia (HP:0000613)2.79485447
49Aplasia/Hypoplasia affecting the retina (HP:0008061)2.77910664
50Congenital sensorineural hearing impairment (HP:0008527)2.76626911
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76499556
52Occipital encephalocele (HP:0002085)2.75146599
53Neoplasm of the tracheobronchial system (HP:0100552)2.73689710
54Alacrima (HP:0000522)2.72111481
55Abnormal biliary tract physiology (HP:0012439)2.71215674
56Bile duct proliferation (HP:0001408)2.71215674
57* Abnormality of the septum pellucidum (HP:0007375)2.67697797
58Heterotopia (HP:0002282)2.66661824
59* Septo-optic dysplasia (HP:0100842)2.60973836
60Dialeptic seizures (HP:0011146)2.60847236
61Natal tooth (HP:0000695)2.60113919
62Partial agenesis of the corpus callosum (HP:0001338)2.58691011
63Hemiparesis (HP:0001269)2.54185571
64Neonatal hypoglycemia (HP:0001998)2.50019435
65Germ cell neoplasia (HP:0100728)2.49491504
66Dysdiadochokinesis (HP:0002075)2.48185629
67Supernumerary spleens (HP:0009799)2.46784139
68Biliary tract neoplasm (HP:0100574)2.45217955
69True hermaphroditism (HP:0010459)2.44432923
70Bifid tongue (HP:0010297)2.44200247
71Alveolar cell carcinoma (HP:0006519)2.43217435
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.40987201
73Depression (HP:0000716)2.39508869
74Embryonal neoplasm (HP:0002898)2.37640966
75Generalized hypopigmentation (HP:0007513)2.37305283
76Gaze-evoked nystagmus (HP:0000640)2.36837306
77Scanning speech (HP:0002168)2.36442447
78Severe Myopia (HP:0011003)2.35935746
79Absent eyebrow (HP:0002223)2.34753367
80Gait imbalance (HP:0002141)2.34555278
81Pigmentary retinal degeneration (HP:0001146)2.32546014
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31900446
83Breech presentation (HP:0001623)2.31879957
84Pancreatic fibrosis (HP:0100732)2.31506066
85Coarctation of aorta (HP:0001680)2.30934097
86Type II diabetes mellitus (HP:0005978)2.29451509
87Chromsome breakage (HP:0040012)2.27752648
88Decreased lacrimation (HP:0000633)2.27143695
89Chorioretinal coloboma (HP:0000567)2.25565697
90Chorioretinal atrophy (HP:0000533)2.24128632
91Smooth philtrum (HP:0000319)2.23787570
92Ankle clonus (HP:0011448)2.23096140
93Sandal gap (HP:0001852)2.21883774
94Midline defect of the nose (HP:0004122)2.20133553
95Prolonged QT interval (HP:0001657)2.18930428
96Congenital primary aphakia (HP:0007707)2.16676527
97Abnormality of the parathyroid morphology (HP:0011766)2.15896901
98Nephrogenic diabetes insipidus (HP:0009806)2.09937108
99Increased cerebral lipofuscin (HP:0011813)2.06635646
100Conjunctival hamartoma (HP:0100780)2.06100463
101Medial flaring of the eyebrow (HP:0010747)2.04517022
102Scrotal hypoplasia (HP:0000046)2.04506832
103Breast aplasia (HP:0100783)2.04123724
104Abnormality of abdominal situs (HP:0011620)2.03412795
105Abdominal situs inversus (HP:0003363)2.03412795
106Retinitis pigmentosa (HP:0000510)2.03188504
107Overlapping toe (HP:0001845)2.01565428
108Squamous cell carcinoma (HP:0002860)2.01555132
109Aqueductal stenosis (HP:0002410)2.00443074
110Hand muscle atrophy (HP:0009130)2.00332688
111Congenital stationary night blindness (HP:0007642)15.4114507
112Fatigue (HP:0012378)1.98675302
113Viral hepatitis (HP:0006562)1.98570311
114Genetic anticipation (HP:0003743)1.96512496
115Furrowed tongue (HP:0000221)1.96439797
116Pancreatic cysts (HP:0001737)1.96164644
117Breast carcinoma (HP:0003002)1.95357429
118Macular degeneration (HP:0000608)1.95194428
119Sparse lateral eyebrow (HP:0005338)1.95019158
120Cutis marmorata (HP:0000965)1.94531276
121Poor coordination (HP:0002370)1.94444298
122Absent radius (HP:0003974)1.93944623
123Arnold-Chiari malformation (HP:0002308)1.92903456
124Action tremor (HP:0002345)1.92358072
125Hamartoma (HP:0010566)1.89375244
126Asplenia (HP:0001746)1.89311470
127Volvulus (HP:0002580)1.89085601
128* Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88515499
129Preaxial hand polydactyly (HP:0001177)1.88129921
130Papillary thyroid carcinoma (HP:0002895)1.87709560
131Abnormality of the umbilical cord (HP:0010881)1.86539085
132Deep palmar crease (HP:0006191)1.86342419
133Aplasia/Hypoplasia of the breasts (HP:0010311)1.86050094
134* Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85863894
135Curly hair (HP:0002212)1.85628296
136Morphological abnormality of the inner ear (HP:0011390)1.84208182
137Constricted visual fields (HP:0001133)1.83850199
138Abnormality of the lower motor neuron (HP:0002366)1.83276338
139Posterior subcapsular cataract (HP:0007787)1.82039306
140Absent eyelashes (HP:0000561)1.80779939
141Lower limb asymmetry (HP:0100559)1.80752133
142Drooling (HP:0002307)1.80164716
143Excessive salivation (HP:0003781)1.80164716
144Neoplasm of the oral cavity (HP:0100649)1.79818628
145Anal stenosis (HP:0002025)1.77450591
146Microvesicular hepatic steatosis (HP:0001414)1.76783453
147Facial cleft (HP:0002006)1.74482753
148Aplasia involving forearm bones (HP:0009822)1.74100604
149Absent forearm bone (HP:0003953)1.74100604
150Optic disc pallor (HP:0000543)1.73710803
151Myokymia (HP:0002411)1.73136108
152Urethral obstruction (HP:0000796)1.72706494
153Anencephaly (HP:0002323)1.72114898
154Aplasia/Hypoplasia of the spleen (HP:0010451)1.71981607
155Morphological abnormality of the middle ear (HP:0008609)1.71920708
156Vitreoretinal degeneration (HP:0000655)1.71547530
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.70750046
158Abnormal sex determination (HP:0012244)1.70532455
159Sex reversal (HP:0012245)1.70532455
160Choroideremia (HP:0001139)1.69921920
161Abnormality of chromosome stability (HP:0003220)1.69493897
162Cafe-au-lait spot (HP:0000957)1.69062465
163Oligodactyly (hands) (HP:0001180)1.68382048
164Abnormality of DNA repair (HP:0003254)1.67050152
165Patellar aplasia (HP:0006443)1.67036032
166Neoplasm of the heart (HP:0100544)1.64603091
167Flat cornea (HP:0007720)1.63445193
168Hemiplegia (HP:0002301)1.60176734
169Unsteady gait (HP:0002317)1.59605533
170Ventricular fibrillation (HP:0001663)1.58461583
171EEG with generalized epileptiform discharges (HP:0011198)1.57616116
172* Optic nerve hypoplasia (HP:0000609)1.57487587
173Aplasia/Hypoplasia of the lens (HP:0008063)1.56546016
174Focal motor seizures (HP:0011153)1.52027275
175Epileptiform EEG discharges (HP:0011182)1.51056038
176Atrial fibrillation (HP:0005110)1.50372514
177Vaginal atresia (HP:0000148)1.47674669
178Astigmatism (HP:0000483)1.47640740
179Large eyes (HP:0001090)1.47357948
180Genital tract atresia (HP:0001827)1.46745138
181Polyphagia (HP:0002591)1.44353922
182Spastic gait (HP:0002064)1.43903983
183Distal upper limb amyotrophy (HP:0007149)1.43779340
184Upper limb amyotrophy (HP:0009129)1.43779340
185Subcapsular cataract (HP:0000523)1.43210721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB44.16283964
2PAK64.07189530
3PBK3.94952056
4PRPF4B3.66534953
5EPHA33.37238188
6MKNK23.01867971
7PHKG22.92978165
8PHKG12.92978165
9DYRK1A2.91102628
10NEK12.84666439
11TAOK22.65873944
12INSRR2.47355785
13MARK12.46547976
14TNIK2.45997240
15SRPK12.11445520
16TNK22.08414934
17MKNK12.06873221
18PINK11.96397867
19LATS11.87330774
20MINK11.87330135
21CASK1.86662387
22CDK121.86658626
23CLK11.86236253
24MAP3K41.85313528
25LMTK21.83287357
26CDK81.82562347
27SGK2231.69775457
28SGK4941.69775457
29AKT31.56983323
30STK161.48217561
31NUAK11.46332417
32PNCK1.44230164
33MAP3K71.42079165
34SGK21.40626827
35GRK11.38507630
36TAOK31.37944891
37STK381.34973108
38MAP3K91.29943356
39CDC71.24891596
40NTRK21.24586609
41ERBB31.21195552
42PAK31.18707349
43MAP2K71.18425175
44FRK1.18255610
45NME11.08984132
46CAMK2D1.07266008
47CDK31.05228543
48DYRK21.04675163
49MAP3K101.03703955
50NTRK31.03319483
51KSR11.02908603
52BUB11.02844766
53ZAK1.02078701
54SGK31.00363018
55FES0.98434715
56ROCK20.97503420
57CDK150.96041764
58CDK140.95314167
59CDK50.94510086
60RIPK10.93073331
61CDK180.92662757
62PRKCG0.90990196
63WNK10.88590950
64CDK11A0.84698169
65PRKCE0.83191359
66MAPK100.83163477
67EPHA40.79004994
68MAPK130.78410484
69TAOK10.77463503
70PKN10.75975723
71PLK30.75532121
72DYRK30.75353041
73SGK10.75300543
74WNK30.74607791
75CDC42BPA0.73793961
76PRKAA10.73207398
77NLK0.72637650
78RPS6KB20.71616861
79FER0.71465507
80SIK10.71099829
81CAMK2A0.69540492
82KSR20.67302234
83PRKG10.67021662
84RPS6KA30.66533975
85CHEK20.65651323
86PRKCZ0.65260046
87DMPK0.64947321
88CDK60.64875938
89BRD40.64409806
90GSK3B0.64206679
91ATM0.63812361
92PRKCA0.63429779
93TYRO30.62640547
94MAPK90.62198497
95PRKACA0.60821606
96DYRK1B0.58497208
97CSNK1A1L0.58474346
98ROCK10.55934255
99CDK90.54385440
100RAF10.52776627
101IRAK20.52624510
102TTK0.52128702
103ATR0.52001926
104PRKG20.51793023
105PRKACB0.51214152
106ICK0.50543594
107MELK0.50415140
108CAMK1D0.50285067
109CSNK1G10.50147828
110TAF10.49808383
111MARK20.49749351
112BMX0.49623165
113AKT10.48919351
114PRKCB0.47937185
115CAMK10.46387282
116CAMK1G0.45770304
117CHEK10.45631153
118MTOR0.45546302
119CSNK1E0.45367925
120CDK20.45200480
121ERBB20.44755001
122PDGFRB0.44320813
123MAPK140.44200170
124ARAF0.43831703
125PDGFRA0.43662902
126PRKACG0.42918638
127PRKD20.42475239
128RPS6KB10.41658662
129NEK60.40649427
130MAPK80.38932238
131FYN0.38029724
132CDK10.37701085
133UHMK10.37222796
134CSNK1G20.36929775
135MAP3K10.36684840
136YES10.36619516
137FGFR20.35749554
138CSNK1D0.35597215
139STK390.34844609
140AKT20.34395953
141RPS6KA40.34022363
142TRIB30.32840634
143CSNK1G30.32409034
144RPS6KA50.32039166
145BRSK20.31056574
146STK40.30679218
147SIK20.30555020
148PRKDC0.29860095
149MAP3K60.28320308
150NEK20.27122995
151STK38L0.26506613
152IRAK30.24963787
153CDK70.24579750
154CDK40.21983112
155PASK0.21614709
156PIM10.20911150
157STK110.20673116
158TLK10.20341951
159MAPK10.19593281
160PLK10.19291589

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.74458677
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.55151771
3Synaptic vesicle cycle_Homo sapiens_hsa047213.84412064
4Phototransduction_Homo sapiens_hsa047443.64747008
5GABAergic synapse_Homo sapiens_hsa047273.56460112
6Morphine addiction_Homo sapiens_hsa050322.97507657
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94182169
8Non-homologous end-joining_Homo sapiens_hsa034502.64361196
9Lysine degradation_Homo sapiens_hsa003102.58786657
10Circadian rhythm_Homo sapiens_hsa047102.43729103
11Circadian entrainment_Homo sapiens_hsa047132.33180637
12Fructose and mannose metabolism_Homo sapiens_hsa000512.27372431
13MicroRNAs in cancer_Homo sapiens_hsa052062.17094402
14RNA transport_Homo sapiens_hsa030132.13571721
15One carbon pool by folate_Homo sapiens_hsa006702.02001857
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.99906044
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91892363
18mRNA surveillance pathway_Homo sapiens_hsa030151.87693416
19Fanconi anemia pathway_Homo sapiens_hsa034601.84414269
20Insulin secretion_Homo sapiens_hsa049111.82457356
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81613783
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.80925984
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79288603
24Cardiac muscle contraction_Homo sapiens_hsa042601.77289798
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76380181
26DNA replication_Homo sapiens_hsa030301.75299814
27Cholinergic synapse_Homo sapiens_hsa047251.74295536
28Prostate cancer_Homo sapiens_hsa052151.69239351
29Basal transcription factors_Homo sapiens_hsa030221.68524482
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63060086
31Olfactory transduction_Homo sapiens_hsa047401.62342225
32Cell cycle_Homo sapiens_hsa041101.61387367
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.58137487
34Biosynthesis of amino acids_Homo sapiens_hsa012301.57315011
35Oxytocin signaling pathway_Homo sapiens_hsa049211.56070411
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55873740
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55508953
38Pentose phosphate pathway_Homo sapiens_hsa000301.51016050
39Salivary secretion_Homo sapiens_hsa049701.48532140
40Non-small cell lung cancer_Homo sapiens_hsa052231.48484886
41Renin secretion_Homo sapiens_hsa049241.46374068
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45163992
43Galactose metabolism_Homo sapiens_hsa000521.42126666
44Homologous recombination_Homo sapiens_hsa034401.42073552
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41151768
46Serotonergic synapse_Homo sapiens_hsa047261.40464369
47Dilated cardiomyopathy_Homo sapiens_hsa054141.40189833
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40114295
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36981770
50Chronic myeloid leukemia_Homo sapiens_hsa052201.36185486
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32016026
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30531508
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30187911
54Mismatch repair_Homo sapiens_hsa034301.27809015
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23995942
56Glioma_Homo sapiens_hsa052141.22173483
57Thyroid cancer_Homo sapiens_hsa052161.22161889
58Pancreatic cancer_Homo sapiens_hsa052121.20615546
59Glutamatergic synapse_Homo sapiens_hsa047241.20062856
60RNA polymerase_Homo sapiens_hsa030201.19462063
61FoxO signaling pathway_Homo sapiens_hsa040681.17727741
62Collecting duct acid secretion_Homo sapiens_hsa049661.17414135
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16147631
64Spliceosome_Homo sapiens_hsa030401.12293611
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08490520
66Acute myeloid leukemia_Homo sapiens_hsa052211.06676307
67Dopaminergic synapse_Homo sapiens_hsa047281.05242908
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04791231
69Calcium signaling pathway_Homo sapiens_hsa040201.04516720
70Mineral absorption_Homo sapiens_hsa049781.00667269
71Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00153748
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99903267
73Type II diabetes mellitus_Homo sapiens_hsa049300.99642594
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99226469
75Small cell lung cancer_Homo sapiens_hsa052220.99100999
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98941681
77Base excision repair_Homo sapiens_hsa034100.95152670
78Nucleotide excision repair_Homo sapiens_hsa034200.94974014
79Long-term potentiation_Homo sapiens_hsa047200.94888689
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89672977
81TGF-beta signaling pathway_Homo sapiens_hsa043500.88406393
82Dorso-ventral axis formation_Homo sapiens_hsa043200.87272671
83Selenocompound metabolism_Homo sapiens_hsa004500.83256121
84RNA degradation_Homo sapiens_hsa030180.81413908
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80964208
86cAMP signaling pathway_Homo sapiens_hsa040240.77166969
87Steroid biosynthesis_Homo sapiens_hsa001000.75706484
88ABC transporters_Homo sapiens_hsa020100.69610727
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68524965
90N-Glycan biosynthesis_Homo sapiens_hsa005100.68007536
91Basal cell carcinoma_Homo sapiens_hsa052170.67954891
92Prolactin signaling pathway_Homo sapiens_hsa049170.67418230
93HIF-1 signaling pathway_Homo sapiens_hsa040660.65210472
94Vitamin B6 metabolism_Homo sapiens_hsa007500.64341635
95Gap junction_Homo sapiens_hsa045400.64200581
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.63880981
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62127817
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61095953
99Carbon metabolism_Homo sapiens_hsa012000.60568221
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.59324808
101ECM-receptor interaction_Homo sapiens_hsa045120.59125968
102Taste transduction_Homo sapiens_hsa047420.58197780
103Endometrial cancer_Homo sapiens_hsa052130.55042610
104Vibrio cholerae infection_Homo sapiens_hsa051100.53033563
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52404251
106Ether lipid metabolism_Homo sapiens_hsa005650.52187322
107Viral carcinogenesis_Homo sapiens_hsa052030.51954450
108Adherens junction_Homo sapiens_hsa045200.51467969
109Inositol phosphate metabolism_Homo sapiens_hsa005620.51144139
110Systemic lupus erythematosus_Homo sapiens_hsa053220.50185311
111Estrogen signaling pathway_Homo sapiens_hsa049150.49996559
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49853682
113VEGF signaling pathway_Homo sapiens_hsa043700.49562465
114Renal cell carcinoma_Homo sapiens_hsa052110.49148694
115Insulin signaling pathway_Homo sapiens_hsa049100.48440932
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48167236
117mTOR signaling pathway_Homo sapiens_hsa041500.48112957
118Insulin resistance_Homo sapiens_hsa049310.48043546
119Hippo signaling pathway_Homo sapiens_hsa043900.44994188
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.44302084
121AMPK signaling pathway_Homo sapiens_hsa041520.43990191
122Axon guidance_Homo sapiens_hsa043600.43382996
123Bladder cancer_Homo sapiens_hsa052190.42256981
124Purine metabolism_Homo sapiens_hsa002300.41366669
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.40521313
126Bile secretion_Homo sapiens_hsa049760.39442688
127Butanoate metabolism_Homo sapiens_hsa006500.39111521
128Long-term depression_Homo sapiens_hsa047300.39041309
129Hedgehog signaling pathway_Homo sapiens_hsa043400.38951133
130Rap1 signaling pathway_Homo sapiens_hsa040150.38734426
131MAPK signaling pathway_Homo sapiens_hsa040100.35856001
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33405452
133Gastric acid secretion_Homo sapiens_hsa049710.30039775
134Alcoholism_Homo sapiens_hsa050340.29264590
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28048080
136GnRH signaling pathway_Homo sapiens_hsa049120.26250880
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.25735404
138Cocaine addiction_Homo sapiens_hsa050300.25724908
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24970656
140Amphetamine addiction_Homo sapiens_hsa050310.24307591
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.23144831
142Glucagon signaling pathway_Homo sapiens_hsa049220.22585676
143Colorectal cancer_Homo sapiens_hsa052100.22537645
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20373561
1452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20025516
146Pyruvate metabolism_Homo sapiens_hsa006200.17930996
147Endocytosis_Homo sapiens_hsa041440.17241492
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.16006448
149Ras signaling pathway_Homo sapiens_hsa040140.15886982
150Pancreatic secretion_Homo sapiens_hsa049720.15535786
151ErbB signaling pathway_Homo sapiens_hsa040120.15256333
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14864068
153Rheumatoid arthritis_Homo sapiens_hsa053230.12982478
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09622294
155Phenylalanine metabolism_Homo sapiens_hsa003600.09592326
156Melanoma_Homo sapiens_hsa052180.09437706
157Choline metabolism in cancer_Homo sapiens_hsa052310.09306519
158Ovarian steroidogenesis_Homo sapiens_hsa049130.09266252
159Protein digestion and absorption_Homo sapiens_hsa049740.09171972
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06329962
161Wnt signaling pathway_Homo sapiens_hsa043100.06037495

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