LHX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.42623334
2central nervous system myelination (GO:0022010)7.42623334
3presynaptic membrane organization (GO:0097090)5.67984963
4axonal fasciculation (GO:0007413)5.54093920
5neuron recognition (GO:0008038)5.23133229
6pyrimidine nucleobase catabolic process (GO:0006208)5.07179231
7response to pheromone (GO:0019236)4.97780584
8neuron cell-cell adhesion (GO:0007158)4.93379211
9righting reflex (GO:0060013)4.49046998
10neurofilament cytoskeleton organization (GO:0060052)4.35739180
11presynaptic membrane assembly (GO:0097105)4.11809872
12cerebral cortex radially oriented cell migration (GO:0021799)4.11468362
13olfactory bulb development (GO:0021772)4.05126661
14* forebrain neuron differentiation (GO:0021879)4.02880977
15cranial nerve morphogenesis (GO:0021602)3.97897670
16positive regulation of action potential (GO:0045760)3.87704487
17establishment of mitochondrion localization (GO:0051654)3.83159974
18nucleobase catabolic process (GO:0046113)3.78538558
19locomotory exploration behavior (GO:0035641)3.77437865
20positive regulation of synapse assembly (GO:0051965)3.76986211
21limb bud formation (GO:0060174)3.72270775
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.66524973
23axon extension involved in axon guidance (GO:0048846)3.66524973
24cerebral cortex neuron differentiation (GO:0021895)3.65501358
25neuronal ion channel clustering (GO:0045161)3.64883749
26auditory behavior (GO:0031223)3.61578990
27axon extension (GO:0048675)3.56418984
28protein polyglutamylation (GO:0018095)3.56208023
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.54360926
30postsynaptic membrane organization (GO:0001941)3.52549773
31spinal cord development (GO:0021510)3.50717337
32negative regulation of axon guidance (GO:1902668)3.50382159
33mitochondrion transport along microtubule (GO:0047497)3.47350356
34establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.47350356
35synapse assembly (GO:0007416)3.41504816
36mechanosensory behavior (GO:0007638)3.39767248
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38456278
38central nervous system projection neuron axonogenesis (GO:0021952)3.38205104
39protein localization to synapse (GO:0035418)3.37456934
40dendritic spine morphogenesis (GO:0060997)3.36520239
41exploration behavior (GO:0035640)3.35363729
42ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.34574884
43long-chain fatty acid biosynthetic process (GO:0042759)3.31863366
44vocalization behavior (GO:0071625)3.30850337
45retina layer formation (GO:0010842)3.27494163
46regulation of synapse assembly (GO:0051963)3.26754519
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24785642
48ganglion development (GO:0061548)3.23567050
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21350546
50regulation of respiratory system process (GO:0044065)3.20988560
51* cell proliferation in forebrain (GO:0021846)3.19255995
52substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.16473139
53substrate-independent telencephalic tangential migration (GO:0021826)3.16473139
54neurotransmitter-gated ion channel clustering (GO:0072578)3.13629061
55opioid receptor signaling pathway (GO:0038003)3.13565237
56* spinal cord association neuron differentiation (GO:0021527)3.11271784
57glutamate receptor signaling pathway (GO:0007215)3.10266956
58startle response (GO:0001964)3.09952684
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09225829
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.07430081
61parturition (GO:0007567)3.06409012
62nonmotile primary cilium assembly (GO:0035058)3.05084672
63negative regulation of osteoblast proliferation (GO:0033689)3.03920085
64microtubule severing (GO:0051013)3.03111788
65intraciliary transport (GO:0042073)3.00912245
66regulation of microtubule-based movement (GO:0060632)3.00561946
67negative regulation of axon extension (GO:0030517)2.98274263
68regulation of respiratory gaseous exchange (GO:0043576)2.96097325
69ionotropic glutamate receptor signaling pathway (GO:0035235)2.95565960
70negative regulation of transcription regulatory region DNA binding (GO:2000678)2.95556242
71body morphogenesis (GO:0010171)2.94405326
72cell migration in hindbrain (GO:0021535)2.92945751
73epithelial cilium movement (GO:0003351)2.92749711
74positive regulation of gastrulation (GO:2000543)2.92510969
75transmission of nerve impulse (GO:0019226)2.91692349
76neuron projection extension (GO:1990138)2.90882386
77regulation of timing of cell differentiation (GO:0048505)2.89384800
78behavioral response to ethanol (GO:0048149)2.89275924
79negative regulation of execution phase of apoptosis (GO:1900118)2.88962745
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86713136
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.85822714
82regulation of cilium movement (GO:0003352)2.85637956
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.85011735
84synaptic transmission, cholinergic (GO:0007271)2.84766761
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83364141
86regulation of feeding behavior (GO:0060259)2.83294695
87short-term memory (GO:0007614)2.83275792
88somite rostral/caudal axis specification (GO:0032525)2.82376934
89negative regulation of protein localization to cell surface (GO:2000009)2.81872651
90negative regulation of neurotransmitter transport (GO:0051589)2.81608506
91reflex (GO:0060004)2.80779444
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80546131
93camera-type eye morphogenesis (GO:0048593)2.80341786
94cerebral cortex cell migration (GO:0021795)2.77612674
95neuron remodeling (GO:0016322)2.76167122
96response to auditory stimulus (GO:0010996)2.75699097
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.75549471
98positive regulation of growth hormone secretion (GO:0060124)2.75263813
99cornea development in camera-type eye (GO:0061303)2.74949664
100behavioral response to nicotine (GO:0035095)2.74458918
101myelination (GO:0042552)2.74158921
102dendrite morphogenesis (GO:0048813)2.73981779
103adult walking behavior (GO:0007628)2.72524006
104somite development (GO:0061053)2.72158197
105specification of organ identity (GO:0010092)2.71503153
106genetic imprinting (GO:0071514)2.71352275
107cranial nerve structural organization (GO:0021604)2.70903566
108regulation of action potential (GO:0098900)2.69781734
109urogenital system development (GO:0001655)2.69283764
110regulation of glutamate receptor signaling pathway (GO:1900449)2.69268278
111* cerebellar Purkinje cell differentiation (GO:0021702)2.67391163
112endoderm formation (GO:0001706)2.66665125
113neuromuscular synaptic transmission (GO:0007274)2.64536498
114telencephalon cell migration (GO:0022029)2.63618629
115calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.63518601
116microtubule bundle formation (GO:0001578)2.63150412
117ensheathment of neurons (GO:0007272)2.63034415
118axon ensheathment (GO:0008366)2.63034415
119dendrite development (GO:0016358)2.61799453
120retinal ganglion cell axon guidance (GO:0031290)2.61407160
121central nervous system neuron axonogenesis (GO:0021955)2.60688644
122regulation of synapse organization (GO:0050807)2.60250911
123forebrain neuron development (GO:0021884)2.58850514
124regulation of growth hormone secretion (GO:0060123)2.58767424
125neuronal action potential propagation (GO:0019227)2.58671437
126uterus development (GO:0060065)2.57497475
127cranial nerve development (GO:0021545)2.56834795
128negative regulation of neurotransmitter secretion (GO:0046929)2.56084097
129neuron migration (GO:0001764)2.56024640
130histone H2B ubiquitination (GO:0033523)2.55980639
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54962280
132regulation of synapse structural plasticity (GO:0051823)2.54892568
133cerebellum development (GO:0021549)2.53769510
134* central nervous system neuron differentiation (GO:0021953)2.53646104
135central nervous system neuron development (GO:0021954)2.52592956
136negative regulation of catecholamine secretion (GO:0033604)2.51157563
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.50756258
138regulation of translation, ncRNA-mediated (GO:0045974)2.50756258
139negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50756258
140axonemal dynein complex assembly (GO:0070286)2.50565973
141synapse organization (GO:0050808)2.50326637
142positive regulation of dendritic spine development (GO:0060999)2.49666080
143regulation of catecholamine metabolic process (GO:0042069)2.49565544
144regulation of dopamine metabolic process (GO:0042053)2.49565544
145negative regulation of axonogenesis (GO:0050771)2.47384767
146forebrain cell migration (GO:0021885)2.46796512
147regulation of development, heterochronic (GO:0040034)2.46658771
148mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.46591598
149regulation of collateral sprouting (GO:0048670)2.43933435
150positive regulation of oligodendrocyte differentiation (GO:0048714)2.43305773
151neuron-neuron synaptic transmission (GO:0007270)2.43183462
152regulation of astrocyte differentiation (GO:0048710)2.42345606
153oligodendrocyte differentiation (GO:0048709)2.41786363
154head development (GO:0060322)2.41062510
155positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40261002
156lateral sprouting from an epithelium (GO:0060601)2.40056982
157neural nucleus development (GO:0048857)2.39163186
158regulation of somitogenesis (GO:0014807)2.38914119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09023592
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.05636518
3GBX2_23144817_ChIP-Seq_PC3_Human3.59305508
4* EZH2_27304074_Chip-Seq_ESCs_Mouse3.08476837
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97091169
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83040892
7* EED_16625203_ChIP-ChIP_MESCs_Mouse2.82466310
8* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.75468813
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74410321
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70000149
11* CBX2_27304074_Chip-Seq_ESCs_Mouse2.68355196
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67588146
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53847046
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53847046
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44130043
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44062852
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42437255
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41351947
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33857935
20TAF15_26573619_Chip-Seq_HEK293_Human2.29533429
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.27449355
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25203911
23* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.24665284
24* RNF2_27304074_Chip-Seq_NSC_Mouse2.19551149
25IGF1R_20145208_ChIP-Seq_DFB_Human2.18568916
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15955629
27VDR_22108803_ChIP-Seq_LS180_Human2.14216108
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97417187
29* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96858738
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.92625461
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92589180
32AR_21572438_ChIP-Seq_LNCaP_Human1.91796326
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85699263
34* REST_21632747_ChIP-Seq_MESCs_Mouse1.82892101
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76452422
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75640571
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72960801
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72506926
39P300_19829295_ChIP-Seq_ESCs_Human1.68787528
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67466545
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64371405
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.62749412
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.54539460
44* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52801109
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51916870
46* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48353303
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46293115
48* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45529332
49* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43082275
50ER_23166858_ChIP-Seq_MCF-7_Human1.40454817
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38915513
52CTCF_27219007_Chip-Seq_Bcells_Human1.37276271
53SMAD4_21799915_ChIP-Seq_A2780_Human1.35706623
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35265800
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34958920
56DROSHA_22980978_ChIP-Seq_HELA_Human1.34955862
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34922527
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34180360
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33781187
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33615893
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.33230041
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33046066
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30929295
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29910524
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29519489
66* REST_18959480_ChIP-ChIP_MESCs_Mouse1.28987263
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.27131717
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26881201
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25998005
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25637902
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23821233
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21328835
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21183004
74* SOX2_16153702_ChIP-ChIP_HESCs_Human1.20156628
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19818661
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.19762665
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19198025
78* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18650995
79P53_22387025_ChIP-Seq_ESCs_Mouse1.18566428
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.17491799
81ZNF274_21170338_ChIP-Seq_K562_Hela1.16394701
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16354024
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.15491171
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.15406372
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15142115
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15055893
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14960859
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14525013
89* TP53_20018659_ChIP-ChIP_R1E_Mouse1.12618175
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11972678
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.10670768
92TP53_18474530_ChIP-ChIP_U2OS_Human1.10632231
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09995469
94IRF1_19129219_ChIP-ChIP_H3396_Human1.09985543
95* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09634231
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.08210104
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.07696997
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.06986181
99AHR_22903824_ChIP-Seq_MCF-7_Human1.05867043
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.05673671
101* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05671837
102* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05671837
103P300_18555785_Chip-Seq_ESCs_Mouse1.04649615
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04416091
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04292911
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03425074
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03300899
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02994252
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.02709638
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02454993
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02261154
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02185870
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00809117
114* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00532434
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00032922
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99602839
117RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99496650
118* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99467389
119FUS_26573619_Chip-Seq_HEK293_Human0.97799906
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.97627548
121SOX2_18555785_Chip-Seq_ESCs_Mouse0.97217867
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96088196
123KDM2B_26808549_Chip-Seq_REH_Human0.95704067
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.95654362
125SALL1_21062744_ChIP-ChIP_HESCs_Human0.91730777
126WDR5_24793694_ChIP-Seq_LNCAP_Human0.90417858
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89709351
128* KDM2B_26808549_Chip-Seq_K562_Human0.88281135
129EWS_26573619_Chip-Seq_HEK293_Human0.86459997
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85323935
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84712418
132* ISL1_27105846_Chip-Seq_CPCs_Mouse0.82365869
133* AR_19668381_ChIP-Seq_PC3_Human0.82110739
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81883973
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80731943
136* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80464947
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80308981
138TP53_22573176_ChIP-Seq_HFKS_Human0.79413272
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79023316
140AR_25329375_ChIP-Seq_VCAP_Human0.78300674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.49729673
2MP0005423_abnormal_somatic_nervous4.03480776
3MP0003123_paternal_imprinting3.33831312
4MP0005645_abnormal_hypothalamus_physiol3.32031940
5MP0006276_abnormal_autonomic_nervous3.00937152
6MP0000566_synostosis2.96751030
7* MP0000778_abnormal_nervous_system2.90972546
8MP0001529_abnormal_vocalization2.85009596
9MP0008995_early_reproductive_senescence2.71173205
10MP0004859_abnormal_synaptic_plasticity2.69843598
11MP0003136_yellow_coat_color2.59402411
12MP0003122_maternal_imprinting2.59073827
13MP0002653_abnormal_ependyma_morphology2.54983671
14MP0006292_abnormal_olfactory_placode2.50368389
15MP0002102_abnormal_ear_morphology2.35013617
16MP0001486_abnormal_startle_reflex2.32114830
17MP0001188_hyperpigmentation2.18790843
18MP0003635_abnormal_synaptic_transmissio2.08188379
19MP0004742_abnormal_vestibular_system2.07121974
20MP0005171_absent_coat_pigmentation2.02656801
21MP0009745_abnormal_behavioral_response1.96197355
22MP0002063_abnormal_learning/memory/cond1.89724320
23MP0002822_catalepsy1.89457764
24MP0002064_seizures1.86210726
25MP0002572_abnormal_emotion/affect_behav1.84835481
26MP0002272_abnormal_nervous_system1.81759673
27MP0005646_abnormal_pituitary_gland1.80617978
28MP0004270_analgesia1.77111151
29MP0002638_abnormal_pupillary_reflex1.71788063
30MP0008877_abnormal_DNA_methylation1.71631340
31MP0002184_abnormal_innervation1.67807656
32MP0001440_abnormal_grooming_behavior1.64426705
33MP0000631_abnormal_neuroendocrine_gland1.63858738
34MP0005409_darkened_coat_color1.63021249
35MP0002557_abnormal_social/conspecific_i1.61071389
36MP0001968_abnormal_touch/_nociception1.59775930
37MP0004381_abnormal_hair_follicle1.55466434
38MP0009046_muscle_twitch1.54725444
39MP0002735_abnormal_chemical_nociception1.54668827
40MP0002938_white_spotting1.53280735
41MP0001984_abnormal_olfaction1.52565121
42MP0009379_abnormal_foot_pigmentation1.52022835
43MP0001293_anophthalmia1.51944811
44MP0004142_abnormal_muscle_tone1.47846296
45MP0002734_abnormal_mechanical_nocicepti1.42377215
46MP0000026_abnormal_inner_ear1.41447440
47MP0001970_abnormal_pain_threshold1.40552694
48MP0002067_abnormal_sensory_capabilities1.40459984
49MP0001502_abnormal_circadian_rhythm1.40419221
50MP0002733_abnormal_thermal_nociception1.39825814
51MP0001905_abnormal_dopamine_level1.37630288
52MP0003942_abnormal_urinary_system1.34989645
53MP0003938_abnormal_ear_development1.32552706
54MP0003121_genomic_imprinting1.31168947
55* MP0002882_abnormal_neuron_morphology1.31006658
56MP0000955_abnormal_spinal_cord1.28735974
57MP0002277_abnormal_respiratory_mucosa1.28649651
58MP0001346_abnormal_lacrimal_gland1.28510598
59MP0010386_abnormal_urinary_bladder1.27838475
60MP0000569_abnormal_digit_pigmentation1.26722294
61MP0003183_abnormal_peptide_metabolism1.24571919
62MP0003646_muscle_fatigue1.23949696
63MP0003011_delayed_dark_adaptation1.23511821
64MP0000920_abnormal_myelination1.23363683
65MP0003119_abnormal_digestive_system1.23361948
66MP0001963_abnormal_hearing_physiology1.21457767
67MP0002160_abnormal_reproductive_system1.20595444
68MP0004924_abnormal_behavior1.19878582
69MP0005386_behavior/neurological_phenoty1.19878582
70MP0005195_abnormal_posterior_eye1.17269870
71MP0002752_abnormal_somatic_nervous1.15670923
72MP0003787_abnormal_imprinting1.15224120
73MP0010030_abnormal_orbit_morphology1.14247082
74MP0001348_abnormal_lacrimal_gland1.06897146
75MP0002736_abnormal_nociception_after1.06000912
76MP0008789_abnormal_olfactory_epithelium1.05331260
77MP0003890_abnormal_embryonic-extraembry1.04597355
78MP0001286_abnormal_eye_development1.03956512
79MP0002751_abnormal_autonomic_nervous1.03906935
80MP0000534_abnormal_ureter_morphology1.03108095
81MP0001299_abnormal_eye_distance/1.02312314
82MP0001485_abnormal_pinna_reflex1.02291860
83MP0004885_abnormal_endolymph1.02235865
84* MP0004811_abnormal_neuron_physiology1.01460904
85MP0005379_endocrine/exocrine_gland_phen1.01260763
86MP0004133_heterotaxia1.00860605
87* MP0002152_abnormal_brain_morphology1.00754389
88MP0002066_abnormal_motor_capabilities/c0.99227776
89MP0005499_abnormal_olfactory_system0.98093655
90MP0005394_taste/olfaction_phenotype0.98093655
91MP0002249_abnormal_larynx_morphology0.98002459
92MP0004134_abnormal_chest_morphology0.97741452
93MP0008569_lethality_at_weaning0.96838311
94MP0005377_hearing/vestibular/ear_phenot0.96790461
95MP0003878_abnormal_ear_physiology0.96790461
96MP0003315_abnormal_perineum_morphology0.95150570
97MP0002876_abnormal_thyroid_physiology0.95055775
98MP0003137_abnormal_impulse_conducting0.94595154
99MP0002909_abnormal_adrenal_gland0.94223112
100MP0005551_abnormal_eye_electrophysiolog0.94096472
101MP0002163_abnormal_gland_morphology0.93126390
102MP0000049_abnormal_middle_ear0.92478189
103MP0000462_abnormal_digestive_system0.90746150
104* MP0003861_abnormal_nervous_system0.90539296
105MP0001501_abnormal_sleep_pattern0.90135280
106MP0002837_dystrophic_cardiac_calcinosis0.87941866
107MP0008260_abnormal_autophagy0.87192194
108MP0002928_abnormal_bile_duct0.86048509
109MP0003937_abnormal_limbs/digits/tail_de0.82845410
110MP0001986_abnormal_taste_sensitivity0.82820502
111MP0000427_abnormal_hair_cycle0.82591402
112MP0003879_abnormal_hair_cell0.81976114
113MP0006072_abnormal_retinal_apoptosis0.81722038
114MP0004130_abnormal_muscle_cell0.81044799
115MP0005391_vision/eye_phenotype0.80237498
116MP0003385_abnormal_body_wall0.79545533
117MP0005187_abnormal_penis_morphology0.79198168
118MP0005253_abnormal_eye_physiology0.78174444
119MP0002233_abnormal_nose_morphology0.78124371
120MP0000538_abnormal_urinary_bladder0.78035936
121MP0005248_abnormal_Harderian_gland0.73794079
122MP0004145_abnormal_muscle_electrophysio0.73443446
123MP0009250_abnormal_appendicular_skeleto0.73351137
124MP0002069_abnormal_eating/drinking_beha0.72753532
125MP0002177_abnormal_outer_ear0.72489448
126MP0000015_abnormal_ear_pigmentation0.71291052
127MP0002116_abnormal_craniofacial_bone0.70399482
128MP0001727_abnormal_embryo_implantation0.69878744
129MP0001943_abnormal_respiration0.69598325

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.38703392
2Abnormal pancreas size (HP:0012094)4.29242710
3Diastasis recti (HP:0001540)3.82673271
4Hepatoblastoma (HP:0002884)3.82054939
5Septo-optic dysplasia (HP:0100842)3.79303435
6Polyphagia (HP:0002591)3.72287503
7Nephronophthisis (HP:0000090)3.41942408
8Abnormal hair whorl (HP:0010721)3.28337594
9Esotropia (HP:0000565)3.23711712
10Pancreatic fibrosis (HP:0100732)3.17433854
11Abnormal eating behavior (HP:0100738)3.17112712
12Broad-based gait (HP:0002136)3.12968910
13Focal seizures (HP:0007359)3.12350475
14Parakeratosis (HP:0001036)3.12080463
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.10359815
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.10359815
17Agitation (HP:0000713)3.06327053
18Thyroid-stimulating hormone excess (HP:0002925)3.03903079
19Abnormality of midbrain morphology (HP:0002418)2.97507258
20Molar tooth sign on MRI (HP:0002419)2.97507258
21Febrile seizures (HP:0002373)2.95886115
22Sleep apnea (HP:0010535)2.91732069
23White forelock (HP:0002211)2.91054563
24Neoplasm of the adrenal cortex (HP:0100641)2.89779002
25Atelectasis (HP:0100750)2.89678784
26Rib fusion (HP:0000902)2.88517597
27Failure to thrive in infancy (HP:0001531)2.78719402
28Abnormality of the renal medulla (HP:0100957)2.77087462
29Absent/shortened dynein arms (HP:0200106)2.73662906
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.73662906
31Aplasia cutis congenita (HP:0001057)2.69705324
32Patchy hypopigmentation of hair (HP:0011365)2.69516043
33Epileptic encephalopathy (HP:0200134)2.68502674
34Adrenal hypoplasia (HP:0000835)2.66421979
35Sex reversal (HP:0012245)2.64134521
36Abnormal sex determination (HP:0012244)2.64134521
37Congenital primary aphakia (HP:0007707)2.59224315
38Hyperventilation (HP:0002883)2.57351195
39Hypoplasia of the brainstem (HP:0002365)2.55604473
40Aplasia/Hypoplasia of the brainstem (HP:0007362)2.55604473
41Vaginal atresia (HP:0000148)2.55444198
42Absent septum pellucidum (HP:0001331)2.55184511
43Abnormality of the corticospinal tract (HP:0002492)2.52606222
44Pancreatic cysts (HP:0001737)2.52068823
45Nephrogenic diabetes insipidus (HP:0009806)2.48312786
46Anophthalmia (HP:0000528)2.47201811
47Genital tract atresia (HP:0001827)2.46481045
48Protruding tongue (HP:0010808)2.45702185
49Alacrima (HP:0000522)2.43961002
50Exotropia (HP:0000577)2.38067245
51Neonatal hypoglycemia (HP:0001998)2.38050858
52Tubular atrophy (HP:0000092)2.37882523
53Impaired vibration sensation in the lower limbs (HP:0002166)2.37645575
54Narrow nasal bridge (HP:0000446)2.36484631
55Lissencephaly (HP:0001339)2.35433372
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34315150
57Anencephaly (HP:0002323)2.32720000
58Cortical dysplasia (HP:0002539)2.31497715
59Abnormality of the septum pellucidum (HP:0007375)2.29623852
60Supernumerary spleens (HP:0009799)2.28463240
61Optic nerve hypoplasia (HP:0000609)2.25971221
62Sclerocornea (HP:0000647)2.25717876
63Abnormal ciliary motility (HP:0012262)2.24750419
64Duplicated collecting system (HP:0000081)2.24546912
65True hermaphroditism (HP:0010459)2.23590503
66Decreased lacrimation (HP:0000633)2.23207335
67Abnormality of the pulmonary veins (HP:0011718)2.17803169
68Drooling (HP:0002307)2.16989143
69Excessive salivation (HP:0003781)2.16989143
70Abnormality of the labia minora (HP:0012880)2.16141937
71Oligodactyly (hands) (HP:0001180)2.12313214
72Duplication of thumb phalanx (HP:0009942)2.11589638
73Occipital encephalocele (HP:0002085)2.10198031
74Growth hormone deficiency (HP:0000824)2.09832638
75Patellar aplasia (HP:0006443)2.08578126
76Hemiparesis (HP:0001269)2.07790574
77Optic nerve coloboma (HP:0000588)2.07728314
78Pachygyria (HP:0001302)2.07407904
79Poor coordination (HP:0002370)2.05671715
80Specific learning disability (HP:0001328)2.05442140
81High anterior hairline (HP:0009890)2.04741229
82Aplasia/Hypoplasia of the lens (HP:0008063)2.04650061
83Cystic liver disease (HP:0006706)2.03766943
84Abnormality of the renal collecting system (HP:0004742)2.02526285
85Type II lissencephaly (HP:0007260)2.02392982
86Aplasia/Hypoplasia of the spleen (HP:0010451)2.02390863
87Reticulocytopenia (HP:0001896)2.02220094
88Abnormality of the intervertebral disk (HP:0005108)2.01668757
89Conical tooth (HP:0000698)2.00756861
90Progressive cerebellar ataxia (HP:0002073)1.99522261
91Shawl scrotum (HP:0000049)1.98857484
92Hip dysplasia (HP:0001385)1.97711912
93Dandy-Walker malformation (HP:0001305)1.97370842
94Limb dystonia (HP:0002451)1.97350522
95Neurofibrillary tangles (HP:0002185)1.96915491
96Genetic anticipation (HP:0003743)1.96039004
97Decreased central vision (HP:0007663)1.95789271
98Abnormality of the axillary hair (HP:0100134)1.94772837
99Abnormality of secondary sexual hair (HP:0009888)1.94772837
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94678430
101Spastic tetraplegia (HP:0002510)1.94556668
102Bony spicule pigmentary retinopathy (HP:0007737)1.93060183
103Blue irides (HP:0000635)1.92049941
104Aplasia/Hypoplasia of the patella (HP:0006498)1.91692381
105Fetal akinesia sequence (HP:0001989)1.91659558
106Absent speech (HP:0001344)1.90057332
107Postaxial foot polydactyly (HP:0001830)1.89750654
108Abnormality of cells of the erythroid lineage (HP:0012130)1.89600592
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89000281
110Hypogonadotrophic hypogonadism (HP:0000044)1.88842539
111Amblyopia (HP:0000646)1.88411245
112Abnormality of the fovea (HP:0000493)1.88170159
113Narrow forehead (HP:0000341)1.88062709
114Atonic seizures (HP:0010819)1.87867691
115Spastic gait (HP:0002064)1.87658585
116Abnormal respiratory motile cilium morphology (HP:0005938)1.87427798
117Abnormal respiratory epithelium morphology (HP:0012253)1.87427798
118Morphological abnormality of the middle ear (HP:0008609)1.87409025
119Gait imbalance (HP:0002141)1.87174741
120Micropenis (HP:0000054)1.86858801
121Abnormal number of incisors (HP:0011064)1.86841243
122Myokymia (HP:0002411)1.86353792
123Abnormality of salivation (HP:0100755)1.86322697
124Osteomalacia (HP:0002749)1.85546194
125Keratoconus (HP:0000563)1.85515670
126Increased corneal curvature (HP:0100692)1.85515670
127Aplasia of the musculature (HP:0100854)1.84137366
128Abnormal respiratory motile cilium physiology (HP:0012261)1.83648930
129Abnormality of the aortic arch (HP:0012303)1.83629757
130Thickened helices (HP:0000391)1.83578733
131Congenital stationary night blindness (HP:0007642)1.83446523
132Autism (HP:0000717)1.83304533
133Abnormality of the lower motor neuron (HP:0002366)1.82895480
134Congenital sensorineural hearing impairment (HP:0008527)1.82704512
135Preaxial hand polydactyly (HP:0001177)1.82477953
136Mixed hearing impairment (HP:0000410)1.81727612
137Asplenia (HP:0001746)1.81546273
138Palpebral edema (HP:0100540)1.80834721
139Renal agenesis (HP:0000104)1.80710441
140Postaxial hand polydactyly (HP:0001162)1.80327435
141Nasolacrimal duct obstruction (HP:0000579)1.79935625
142Retinal dysplasia (HP:0007973)1.78262550
143Labial hypoplasia (HP:0000066)1.77909212
144Ankle clonus (HP:0011448)1.77825072
145Poor suck (HP:0002033)1.77787860
146Medial flaring of the eyebrow (HP:0010747)1.76591800
147Neonatal respiratory distress (HP:0002643)1.75701556
148Anosmia (HP:0000458)1.74975862
149Inability to walk (HP:0002540)1.74580501
150Chorioretinal coloboma (HP:0000567)1.74277649
151Intellectual disability, moderate (HP:0002342)1.73510318
152Urinary bladder sphincter dysfunction (HP:0002839)1.72971157
153Overfolded helix (HP:0000396)1.72664553
154Peripheral hypomyelination (HP:0007182)1.72070726
155Hyperglycinemia (HP:0002154)1.71441999
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71047578
157Severe Myopia (HP:0011003)1.70717158
158Holoprosencephaly (HP:0001360)1.70557950
159Hypoplasia of the iris (HP:0007676)1.69144529
160Hypothermia (HP:0002045)1.68925112
161Chronic hepatic failure (HP:0100626)1.68681268
162Anomalous pulmonary venous return (HP:0010772)1.68591983
163Septate vagina (HP:0001153)1.67445780
164Supranuclear gaze palsy (HP:0000605)1.67154603
165Abnormality of macular pigmentation (HP:0008002)1.67109803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.71800476
2SIK32.97868238
3MARK12.96180234
4DYRK22.56675569
5EPHA32.45136334
6DYRK32.36564165
7BCR2.30906204
8ACVR1B2.17038740
9TNIK2.11028661
10NTRK22.10977321
11ZAK2.01848368
12NTRK32.01451107
13MAPK132.00427826
14IRAK21.95187987
15INSRR1.89522075
16MAP2K71.88314373
17OXSR11.84400871
18FGFR21.82766837
19UHMK11.82682770
20BLK1.81103375
21WNK31.76538131
22SIK21.70599669
23PRPF4B1.65202566
24DYRK1B1.60104341
25PKN11.59608952
26CDK191.59439236
27BMPR1B1.56117638
28MKNK21.50276879
29STK391.49760971
30BRD41.49577966
31YES11.42650671
32FRK1.42198951
33PAK61.39672972
34STK161.38700165
35ADRBK21.38402976
36PINK11.35385489
37EPHB21.34190756
38TYRO31.33672793
39MAP3K121.33305970
40MAP3K41.24770658
41STK111.19289071
42KSR11.18096430
43CAMK1G1.15066121
44MAP3K91.14386788
45MKNK11.08275512
46FGR1.05132881
47SGK21.03216784
48ERBB31.03020781
49CAMK1D1.02805483
50IRAK41.02653667
51RPS6KA20.98531098
52IRAK10.94614661
53CAMK2B0.94008317
54GRK10.92233643
55NEK20.90696700
56CLK10.90207364
57ROCK20.88797179
58EPHA40.87133237
59DDR20.86206606
60CDK50.84274973
61NEK60.84192603
62CAMKK10.84172594
63PRKCE0.84036645
64PNCK0.83761347
65ERBB20.82053057
66SGK2230.80880892
67SGK4940.80880892
68BMPR20.80846874
69GRK70.80435485
70VRK10.78357592
71PRKCH0.76728657
72TRIM280.76276829
73DAPK20.74998953
74MAPK150.72999478
75DYRK1A0.71261479
76PLK20.71179559
77CAMK10.71158676
78SGK30.68608090
79CAMK2A0.67481069
80CSNK1G30.67147318
81CSNK1E0.65930947
82TXK0.64898852
83MAP2K40.63302188
84MAP3K60.62899962
85SRPK10.62746407
86EIF2AK20.62327273
87PBK0.62282797
88MAP3K110.61861735
89MATK0.61536648
90MUSK0.61367612
91CSNK1A1L0.61091379
92MAP4K20.58187729
93FES0.57745925
94PAK30.57650908
95PHKG20.56718938
96PHKG10.56718938
97CDK180.56159653
98PRKACA0.55886973
99ICK0.55691285
100CAMK40.55421309
101MINK10.54356314
102BCKDK0.52070717
103MARK20.51571211
104CAMK2D0.50641881
105PRKG10.47357059
106MAPK90.47263195
107FYN0.47225255
108LIMK10.46904023
109MAP3K130.46666252
110CSNK1G20.46230422
111TLK10.46213975
112ADRBK10.45713913
113PLK10.45580262
114CDK150.45217586
115PRKAA10.45055971
116AURKA0.44401449
117CDK140.44005655
118GRK50.43958563
119PRKCG0.43868933
120CDK30.43200687
121RPS6KA60.43102154
122CDC70.42938488
123PRKCZ0.40765958
124LATS10.40218811
125CDK11A0.40207365
126NUAK10.40001829
127STK380.39996011
128DMPK0.39619849
129SGK10.39381998
130AKT10.38978230
131CSNK1A10.38858703
132MARK30.36181256
133FER0.36178316
134CSNK1D0.36113705
135CSNK1G10.35597149
136MAP3K140.35215115
137BRAF0.34821069
138MAPK80.34234843
139WNK40.33762234
140TNK20.33690984
141TAF10.33536955

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.95987315
2Axon guidance_Homo sapiens_hsa043603.34529875
3Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.26237546
4Morphine addiction_Homo sapiens_hsa050322.24311568
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23846092
6GABAergic synapse_Homo sapiens_hsa047272.23622461
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15278228
8Glutamatergic synapse_Homo sapiens_hsa047242.13044567
9Serotonergic synapse_Homo sapiens_hsa047262.06517761
10Phototransduction_Homo sapiens_hsa047442.04432731
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98302814
12Ribosome_Homo sapiens_hsa030101.96753593
13Taste transduction_Homo sapiens_hsa047421.95258996
14Circadian entrainment_Homo sapiens_hsa047131.75629199
15Oxidative phosphorylation_Homo sapiens_hsa001901.71447887
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.69571076
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62132588
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60673113
19Cocaine addiction_Homo sapiens_hsa050301.59763020
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52806044
21Ether lipid metabolism_Homo sapiens_hsa005651.44273354
22Long-term depression_Homo sapiens_hsa047301.37663832
23Synaptic vesicle cycle_Homo sapiens_hsa047211.35885524
24Hippo signaling pathway_Homo sapiens_hsa043901.33831594
25Sphingolipid metabolism_Homo sapiens_hsa006001.33819953
26Cardiac muscle contraction_Homo sapiens_hsa042601.31686239
27Collecting duct acid secretion_Homo sapiens_hsa049661.28381761
28Steroid biosynthesis_Homo sapiens_hsa001001.27698835
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25622685
30Dopaminergic synapse_Homo sapiens_hsa047281.21777088
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20172086
32Cholinergic synapse_Homo sapiens_hsa047251.18845661
33Salivary secretion_Homo sapiens_hsa049701.17579230
34Calcium signaling pathway_Homo sapiens_hsa040201.13457117
35ErbB signaling pathway_Homo sapiens_hsa040121.13371071
36Basal cell carcinoma_Homo sapiens_hsa052171.11657512
37Vibrio cholerae infection_Homo sapiens_hsa051101.11148482
38Olfactory transduction_Homo sapiens_hsa047401.09984602
39Alzheimers disease_Homo sapiens_hsa050101.09421827
40Amphetamine addiction_Homo sapiens_hsa050311.08925182
41Insulin secretion_Homo sapiens_hsa049111.08246497
42Autoimmune thyroid disease_Homo sapiens_hsa053201.07668548
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07315517
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04916295
45Wnt signaling pathway_Homo sapiens_hsa043101.01638634
46Parkinsons disease_Homo sapiens_hsa050121.00845619
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99894986
48Oxytocin signaling pathway_Homo sapiens_hsa049210.97549064
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97081669
50Gastric acid secretion_Homo sapiens_hsa049710.93557194
51Gap junction_Homo sapiens_hsa045400.93382462
52Fatty acid elongation_Homo sapiens_hsa000620.92052878
53Renin secretion_Homo sapiens_hsa049240.92037091
54Ras signaling pathway_Homo sapiens_hsa040140.91825205
55Phagosome_Homo sapiens_hsa041450.91385869
56Hedgehog signaling pathway_Homo sapiens_hsa043400.90926935
57Arachidonic acid metabolism_Homo sapiens_hsa005900.90672284
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87703691
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84348816
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83886030
61Ovarian steroidogenesis_Homo sapiens_hsa049130.83484843
62Melanogenesis_Homo sapiens_hsa049160.82682504
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82506416
64Rheumatoid arthritis_Homo sapiens_hsa053230.80379446
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80120391
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78535738
67Huntingtons disease_Homo sapiens_hsa050160.76793156
68Butanoate metabolism_Homo sapiens_hsa006500.76385066
69cAMP signaling pathway_Homo sapiens_hsa040240.75539101
70Asthma_Homo sapiens_hsa053100.74506448
71Linoleic acid metabolism_Homo sapiens_hsa005910.72604400
72Notch signaling pathway_Homo sapiens_hsa043300.71977356
73Long-term potentiation_Homo sapiens_hsa047200.71400056
74Graft-versus-host disease_Homo sapiens_hsa053320.68792479
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65230590
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.64093628
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64034792
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.61597326
79Tryptophan metabolism_Homo sapiens_hsa003800.61519183
80Protein export_Homo sapiens_hsa030600.61377477
81MAPK signaling pathway_Homo sapiens_hsa040100.61370334
82Type II diabetes mellitus_Homo sapiens_hsa049300.61192466
83Dilated cardiomyopathy_Homo sapiens_hsa054140.60808964
84Fat digestion and absorption_Homo sapiens_hsa049750.60784661
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59164677
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57240345
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57176986
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57051666
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56571059
90GnRH signaling pathway_Homo sapiens_hsa049120.56073800
91Renal cell carcinoma_Homo sapiens_hsa052110.56032807
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54315402
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53946615
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52933853
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52777575
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52073518
97Regulation of autophagy_Homo sapiens_hsa041400.50779371
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.50757867
99Choline metabolism in cancer_Homo sapiens_hsa052310.50718895
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50353500
101VEGF signaling pathway_Homo sapiens_hsa043700.49899641
102* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49435409
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48645082
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48611714
105Allograft rejection_Homo sapiens_hsa053300.46400005
106Alcoholism_Homo sapiens_hsa050340.45482161
107Rap1 signaling pathway_Homo sapiens_hsa040150.45375749
108Fanconi anemia pathway_Homo sapiens_hsa034600.45090573
109Colorectal cancer_Homo sapiens_hsa052100.44455614
110RNA degradation_Homo sapiens_hsa030180.44208105
111Caffeine metabolism_Homo sapiens_hsa002320.43901037
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.43679943
113Pancreatic secretion_Homo sapiens_hsa049720.43253460
114African trypanosomiasis_Homo sapiens_hsa051430.43200142
115Basal transcription factors_Homo sapiens_hsa030220.42929739
116Thyroid hormone synthesis_Homo sapiens_hsa049180.42636738
117Inositol phosphate metabolism_Homo sapiens_hsa005620.42375889
118Retinol metabolism_Homo sapiens_hsa008300.42024790
119Tight junction_Homo sapiens_hsa045300.41758034
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41538727
121Chemokine signaling pathway_Homo sapiens_hsa040620.40656750
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.40361348
123Peroxisome_Homo sapiens_hsa041460.38856079
124Mineral absorption_Homo sapiens_hsa049780.38241148
125Dorso-ventral axis formation_Homo sapiens_hsa043200.38191127
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.35450448
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33162660
128Nitrogen metabolism_Homo sapiens_hsa009100.29910631
129Lysine degradation_Homo sapiens_hsa003100.29589477
130Glycerolipid metabolism_Homo sapiens_hsa005610.28958905

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