LHX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.57253843
2protein-cofactor linkage (GO:0018065)6.31287669
3positive regulation of mitochondrial fission (GO:0090141)6.23533173
4vocalization behavior (GO:0071625)5.33046024
5nucleobase catabolic process (GO:0046113)5.04610103
6regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.90591979
7central nervous system projection neuron axonogenesis (GO:0021952)4.84786594
8neurotransmitter-gated ion channel clustering (GO:0072578)4.69020646
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.63970336
10regulation of synaptic vesicle exocytosis (GO:2000300)4.59700164
11regulation of mitochondrial fission (GO:0090140)4.55733695
12neuron recognition (GO:0008038)4.55642244
13axonal fasciculation (GO:0007413)4.46778128
14neuron cell-cell adhesion (GO:0007158)4.43758602
15negative regulation of neurotransmitter secretion (GO:0046929)4.38754271
16postsynaptic membrane organization (GO:0001941)4.37306089
17exploration behavior (GO:0035640)4.36113671
18regulation of glutamate receptor signaling pathway (GO:1900449)4.34609864
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.30705459
20gamma-aminobutyric acid transport (GO:0015812)4.22022022
21presynaptic membrane assembly (GO:0097105)4.20296890
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.07506063
23negative regulation of oligodendrocyte differentiation (GO:0048715)4.02491813
24synaptic vesicle exocytosis (GO:0016079)4.00074544
25locomotory exploration behavior (GO:0035641)3.90549898
26regulation of synaptic vesicle transport (GO:1902803)3.90199924
27spinal cord development (GO:0021510)3.89532923
28negative regulation of neurotransmitter transport (GO:0051589)3.87089035
29regulation of synapse structural plasticity (GO:0051823)3.83686639
30neurotransmitter biosynthetic process (GO:0042136)3.83460322
31dendrite morphogenesis (GO:0048813)3.82645461
32glycerophospholipid catabolic process (GO:0046475)3.79877162
33response to pheromone (GO:0019236)3.78049811
34piRNA metabolic process (GO:0034587)3.76982031
35glycosphingolipid biosynthetic process (GO:0006688)3.75823315
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75545297
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74877813
38regulation of glycogen (starch) synthase activity (GO:2000465)3.74603596
39* cerebral cortex cell migration (GO:0021795)3.74584458
40axon extension (GO:0048675)3.72115162
41sequestering of actin monomers (GO:0042989)3.70797783
42* cerebral cortex radially oriented cell migration (GO:0021799)3.70554407
43cardiac chamber formation (GO:0003207)3.62842767
44presynaptic membrane organization (GO:0097090)3.58614139
45regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55100582
46synaptic vesicle maturation (GO:0016188)3.50176135
47central nervous system neuron axonogenesis (GO:0021955)3.49116370
48synaptic vesicle endocytosis (GO:0048488)3.47646839
49regulation of synapse maturation (GO:0090128)3.45297864
50forebrain neuron differentiation (GO:0021879)3.43311065
51hippocampus development (GO:0021766)3.40660495
52synaptic transmission, glutamatergic (GO:0035249)3.40657834
53DNA methylation involved in gamete generation (GO:0043046)3.39419658
54positive regulation of synapse maturation (GO:0090129)3.39052728
55protein localization to synapse (GO:0035418)3.37536815
56dendritic spine morphogenesis (GO:0060997)3.35008990
57regulation of protein kinase A signaling (GO:0010738)3.34554290
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.31627405
59regulation of neurotransmitter levels (GO:0001505)3.31393699
60regulation of dendritic spine morphogenesis (GO:0061001)3.29207761
61neurotransmitter secretion (GO:0007269)3.27889055
62ganglion development (GO:0061548)3.27806960
63glutamate secretion (GO:0014047)3.26635400
64facial nerve structural organization (GO:0021612)3.26614358
65neuron-neuron synaptic transmission (GO:0007270)3.25874707
66axon extension involved in axon guidance (GO:0048846)3.25195610
67neuron projection extension involved in neuron projection guidance (GO:1902284)3.25195610
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24518038
69negative regulation of axon extension involved in axon guidance (GO:0048843)3.22563640
70regulation of actin nucleation (GO:0051125)3.20468963
71adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.19080999
72negative regulation of stem cell proliferation (GO:2000647)3.18702407
73epithelial cell differentiation involved in kidney development (GO:0035850)3.18588460
74regulation of NFAT protein import into nucleus (GO:0051532)3.17947187
75positive regulation of amino acid transport (GO:0051957)3.17882067
76negative regulation of dendrite development (GO:2000171)3.15630623
77positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.13802617
78mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.13802617
79negative regulation of axon guidance (GO:1902668)3.13360319
80* substrate-independent telencephalic tangential migration (GO:0021826)3.12090167
81* substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.12090167
82negative regulation of Notch signaling pathway (GO:0045746)3.11132604
83calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.10956173
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10485095
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.09063411
86cell wall macromolecule catabolic process (GO:0016998)3.08453482
87glial cell proliferation (GO:0014009)3.07948442
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06012109
89negative regulation of JAK-STAT cascade (GO:0046426)3.05238415
90behavioral response to nicotine (GO:0035095)3.04549509
91layer formation in cerebral cortex (GO:0021819)3.03178697
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02175471
93cellular component maintenance (GO:0043954)3.01305083
94regulation of neuron migration (GO:2001222)3.00414494
95positive regulation of synapse assembly (GO:0051965)3.00110937
96regulation of neuronal synaptic plasticity (GO:0048168)2.99337011
97neurotransmitter metabolic process (GO:0042133)2.98734682
98regulation of transcription involved in cell fate commitment (GO:0060850)2.98039295
99limb bud formation (GO:0060174)2.97018814
100protein localization to cilium (GO:0061512)2.96236990
101proline transport (GO:0015824)2.95990624
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95935109
103neuron projection extension (GO:1990138)2.94836770
104sympathetic nervous system development (GO:0048485)2.92704535
105cell migration in hindbrain (GO:0021535)2.91908105
106regulation of synaptic transmission, GABAergic (GO:0032228)2.91377736
107glycine transport (GO:0015816)2.91214501
108neurotransmitter transport (GO:0006836)2.88904340
109dicarboxylic acid catabolic process (GO:0043649)2.88845293
110replicative senescence (GO:0090399)2.87520646
111neuronal ion channel clustering (GO:0045161)2.87271216
112negative regulation of exocytosis (GO:0045920)2.86904080
113neuronal action potential propagation (GO:0019227)2.86525051
114long-term synaptic potentiation (GO:0060291)2.86423669
115negative regulation of appetite (GO:0032099)2.86022535
116negative regulation of response to food (GO:0032096)2.86022535
117head development (GO:0060322)2.83678167
118mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.83263935
119cardiac ventricle formation (GO:0003211)2.82224672
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81424163
121succinate metabolic process (GO:0006105)2.81312140
122positive regulation of membrane potential (GO:0045838)2.76988493
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76534465
124positive regulation of neurotransmitter transport (GO:0051590)2.76204413
125regulation of Rac GTPase activity (GO:0032314)2.76148546
126regulation of feeding behavior (GO:0060259)2.75238735
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.74178551
128positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73933462
129long-term memory (GO:0007616)2.72707601
130negative regulation of dendrite morphogenesis (GO:0050774)2.72041670
131regulation of neurotransmitter secretion (GO:0046928)2.71667601
132synapse assembly (GO:0007416)2.71659503
133* telencephalon cell migration (GO:0022029)2.71325880
134startle response (GO:0001964)2.71232707
135cranial nerve structural organization (GO:0021604)2.70733325
136cAMP catabolic process (GO:0006198)2.70318361
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.70244677
138cerebral cortex neuron differentiation (GO:0021895)2.69389911
139de novo posttranslational protein folding (GO:0051084)2.68726841
140regulation of dendrite morphogenesis (GO:0048814)2.67049314
141establishment of mitochondrion localization (GO:0051654)2.67045594
142regulation of membrane repolarization (GO:0060306)2.66821234
143glutamate receptor signaling pathway (GO:0007215)2.66269866
144positive regulation of vascular permeability (GO:0043117)2.65959856
145regulation of vesicle fusion (GO:0031338)2.65458596
146long term synaptic depression (GO:0060292)2.63404530
147synaptic vesicle transport (GO:0048489)2.61796155
148establishment of synaptic vesicle localization (GO:0097480)2.61796155
149positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.61480542
150sialylation (GO:0097503)2.60860010
151regulation of synapse assembly (GO:0051963)2.60836347
152regulation of axon guidance (GO:1902667)2.60758525
153regulation of response to food (GO:0032095)2.60549945
154homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.60325489
155microtubule depolymerization (GO:0007019)2.57731848
156dendritic spine organization (GO:0097061)2.57138470
157vesicle transport along microtubule (GO:0047496)2.56747080
158de novo protein folding (GO:0006458)2.56084750
159regulation of sarcomere organization (GO:0060297)2.55553485
160establishment of vesicle localization (GO:0051650)2.55502750
161cell wall macromolecule metabolic process (GO:0044036)2.54992683
162L-methionine biosynthetic process (GO:0071265)2.54182722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91312636
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.47515517
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.01540210
4GBX2_23144817_ChIP-Seq_PC3_Human3.83124650
5ZNF274_21170338_ChIP-Seq_K562_Hela2.80385493
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.79618996
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69821003
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.68189612
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63250016
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43605077
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43094766
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41602147
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41602147
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38544275
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.27822294
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25741878
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25320236
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19312399
19REST_21632747_ChIP-Seq_MESCs_Mouse2.18436528
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17599257
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13789192
22* EED_16625203_ChIP-ChIP_MESCs_Mouse2.13313009
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10902382
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09571122
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07515367
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07153919
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02751889
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01618604
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99871873
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99702591
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96321672
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94466541
33IGF1R_20145208_ChIP-Seq_DFB_Human1.94135307
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93982010
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93942811
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93369867
37* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92967525
38DROSHA_22980978_ChIP-Seq_HELA_Human1.82550362
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.77952244
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75728913
41VDR_22108803_ChIP-Seq_LS180_Human1.75576352
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74430948
43* CBX2_27304074_Chip-Seq_ESCs_Mouse1.74370970
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71835672
45FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.69930843
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63819520
47RNF2_27304074_Chip-Seq_NSC_Mouse1.63324080
48* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61535700
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60519635
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.60268701
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.59968041
52* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59617498
53* P300_19829295_ChIP-Seq_ESCs_Human1.51362419
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49124480
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.47493527
56TAF15_26573619_Chip-Seq_HEK293_Human1.47423722
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.46829929
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.46543957
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44463279
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42879207
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.41772835
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40141512
63SMAD4_21799915_ChIP-Seq_A2780_Human1.38651957
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.37328477
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36786202
66CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.36502365
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35555478
68GABP_19822575_ChIP-Seq_HepG2_Human1.34437843
69TP53_22573176_ChIP-Seq_HFKS_Human1.31504021
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30454505
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.30390365
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.29847810
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.29225794
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28594453
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27371822
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26662648
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.25257054
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24657912
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24456508
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24113014
81STAT3_23295773_ChIP-Seq_U87_Human1.23288577
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22745550
83AR_21572438_ChIP-Seq_LNCaP_Human1.22196045
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22015879
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21855515
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20541734
87TP53_18474530_ChIP-ChIP_U2OS_Human1.20152862
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.19812106
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.17274760
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16305488
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14851712
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14320384
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13287580
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13272607
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12368324
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12368324
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11807608
98RUNX2_22187159_ChIP-Seq_PCA_Human1.11519215
99AR_19668381_ChIP-Seq_PC3_Human1.09449007
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09356923
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09033710
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.08611207
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08158655
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08124016
105FUS_26573619_Chip-Seq_HEK293_Human1.07045973
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06863034
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06782898
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06778848
109AR_25329375_ChIP-Seq_VCAP_Human1.06326975
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06241943
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05514161
112* TP53_20018659_ChIP-ChIP_R1E_Mouse1.04528251
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03972558
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02933130
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02242345
116* TCF4_23295773_ChIP-Seq_U87_Human1.01608865
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01507210
118AHR_22903824_ChIP-Seq_MCF-7_Human1.01366721
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.01010028
120SALL1_21062744_ChIP-ChIP_HESCs_Human1.00993962
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.00362867
122* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99842791
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99096604
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98968538
125BCAT_22108803_ChIP-Seq_LS180_Human0.98899745
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96526071
127ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96192757
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94970550
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.94905618
130ER_23166858_ChIP-Seq_MCF-7_Human0.92196499
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.90018627
132RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88656450
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87827419
134* OCT4_20526341_ChIP-Seq_ESCs_Human0.87511180
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.86275234
136NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86227423
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85088295
138RAC3_21632823_ChIP-Seq_H3396_Human0.84735545
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84038619
140MYC_19829295_ChIP-Seq_ESCs_Human0.83449412
141* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83408159
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83392680
143* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83342517
144MYC_18940864_ChIP-ChIP_HL60_Human0.82533800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.37525125
2MP0004859_abnormal_synaptic_plasticity4.36069077
3MP0008995_early_reproductive_senescence3.60000793
4MP0003880_abnormal_central_pattern3.26272497
5MP0005645_abnormal_hypothalamus_physiol3.11288377
6MP0004858_abnormal_nervous_system2.93620714
7MP0003635_abnormal_synaptic_transmissio2.88848198
8MP0006276_abnormal_autonomic_nervous2.84719090
9MP0002063_abnormal_learning/memory/cond2.69664064
10MP0003221_abnormal_cardiomyocyte_apopto2.67565887
11MP0006292_abnormal_olfactory_placode2.61412715
12MP0003122_maternal_imprinting2.41642775
13MP0002572_abnormal_emotion/affect_behav2.32405764
14MP0009745_abnormal_behavioral_response2.29241285
15MP0002638_abnormal_pupillary_reflex2.28507893
16MP0005423_abnormal_somatic_nervous2.26324736
17MP0003385_abnormal_body_wall2.20141788
18MP0002736_abnormal_nociception_after2.18374790
19MP0000778_abnormal_nervous_system2.07770332
20MP0002557_abnormal_social/conspecific_i2.02621305
21MP0002184_abnormal_innervation2.02367247
22MP0004270_analgesia1.99792292
23MP0003646_muscle_fatigue1.93532808
24MP0001968_abnormal_touch/_nociception1.90628208
25MP0001529_abnormal_vocalization1.89695652
26MP0002064_seizures1.88824719
27MP0009046_muscle_twitch1.82864549
28MP0001486_abnormal_startle_reflex1.78473339
29MP0003787_abnormal_imprinting1.78180031
30MP0002734_abnormal_mechanical_nocicepti1.78163094
31MP0005646_abnormal_pituitary_gland1.74496430
32MP0002102_abnormal_ear_morphology1.73607634
33MP0000049_abnormal_middle_ear1.68134884
34* MP0004811_abnormal_neuron_physiology1.63453062
35MP0000631_abnormal_neuroendocrine_gland1.63267424
36MP0004233_abnormal_muscle_weight1.58636430
37MP0001984_abnormal_olfaction1.50243436
38MP0002272_abnormal_nervous_system1.47290434
39MP0000013_abnormal_adipose_tissue1.45152425
40MP0009780_abnormal_chondrocyte_physiolo1.43497696
41MP0008058_abnormal_DNA_repair1.42603263
42MP0000955_abnormal_spinal_cord1.40161067
43MP0000678_abnormal_parathyroid_gland1.39623069
44MP0009697_abnormal_copulation1.38856463
45MP0002735_abnormal_chemical_nociception1.37393130
46MP0008569_lethality_at_weaning1.33341190
47MP0000569_abnormal_digit_pigmentation1.31722857
48MP0005394_taste/olfaction_phenotype1.31451961
49MP0005499_abnormal_olfactory_system1.31451961
50MP0002249_abnormal_larynx_morphology1.30357520
51MP0008789_abnormal_olfactory_epithelium1.29296238
52MP0003011_delayed_dark_adaptation1.27828162
53MP0003786_premature_aging1.26813148
54MP0003755_abnormal_palate_morphology1.24608371
55MP0001293_anophthalmia1.23790374
56MP0005386_behavior/neurological_phenoty1.23482122
57MP0004924_abnormal_behavior1.23482122
58MP0002277_abnormal_respiratory_mucosa1.22865557
59MP0002653_abnormal_ependyma_morphology1.21763023
60MP0004885_abnormal_endolymph1.19526904
61MP0001501_abnormal_sleep_pattern1.19256337
62MP0000015_abnormal_ear_pigmentation1.18257815
63MP0002733_abnormal_thermal_nociception1.18185847
64MP0000516_abnormal_urinary_system1.17597778
65MP0005367_renal/urinary_system_phenotyp1.17597778
66MP0004147_increased_porphyrin_level1.17483239
67MP0002876_abnormal_thyroid_physiology1.16377018
68MP0002067_abnormal_sensory_capabilities1.13130090
69MP0002332_abnormal_exercise_endurance1.12974868
70MP0004085_abnormal_heartbeat1.12077596
71MP0001986_abnormal_taste_sensitivity1.11071373
72MP0002882_abnormal_neuron_morphology1.09811077
73MP0005248_abnormal_Harderian_gland1.06705654
74MP0001440_abnormal_grooming_behavior1.06313161
75MP0003119_abnormal_digestive_system1.06281042
76MP0002751_abnormal_autonomic_nervous1.05894036
77MP0004142_abnormal_muscle_tone1.05363194
78MP0002822_catalepsy1.02411977
79MP0001502_abnormal_circadian_rhythm1.00974340
80MP0008875_abnormal_xenobiotic_pharmacok1.00377120
81MP0001970_abnormal_pain_threshold1.00191664
82MP0000566_synostosis0.99986123
83* MP0002152_abnormal_brain_morphology0.99856212
84MP0005451_abnormal_body_composition0.98735199
85MP0003861_abnormal_nervous_system0.98500888
86* MP0002066_abnormal_motor_capabilities/c0.98252238
87MP0001270_distended_abdomen0.96634412
88MP0004484_altered_response_of0.96495198
89MP0002069_abnormal_eating/drinking_beha0.95795706
90MP0004742_abnormal_vestibular_system0.95192374
91MP0004043_abnormal_pH_regulation0.95026356
92MP0003121_genomic_imprinting0.94991964
93MP0005187_abnormal_penis_morphology0.94900636
94MP0003698_abnormal_male_reproductive0.93458793
95MP0002234_abnormal_pharynx_morphology0.91826560
96MP0005171_absent_coat_pigmentation0.91369209
97MP0000749_muscle_degeneration0.90328009
98MP0001177_atelectasis0.89863644
99MP0003935_abnormal_craniofacial_develop0.89304030
100MP0005623_abnormal_meninges_morphology0.86236166
101MP0002177_abnormal_outer_ear0.86214748
102MP0002116_abnormal_craniofacial_bone0.85277016
103MP0001905_abnormal_dopamine_level0.85187744
104MP0003938_abnormal_ear_development0.84749981
105MP0004134_abnormal_chest_morphology0.83296911
106MP0006138_congestive_heart_failure0.82806502
107MP0005551_abnormal_eye_electrophysiolog0.81317620
108MP0002210_abnormal_sex_determination0.79733542
109MP0003879_abnormal_hair_cell0.78946581
110MP0003942_abnormal_urinary_system0.78587285
111MP0004036_abnormal_muscle_relaxation0.77984897
112MP0002081_perinatal_lethality0.76551712
113MP0002909_abnormal_adrenal_gland0.75998933
114MP0000681_abnormal_thyroid_gland0.75878816
115MP0002752_abnormal_somatic_nervous0.75665771
116MP0005084_abnormal_gallbladder_morpholo0.74458769
117MP0004215_abnormal_myocardial_fiber0.72878631
118MP0002233_abnormal_nose_morphology0.71959599
119MP0000647_abnormal_sebaceous_gland0.71954538
120MP0009250_abnormal_appendicular_skeleto0.71896369
121MP0001929_abnormal_gametogenesis0.70193479
122MP0002089_abnormal_postnatal_growth/wei0.69529347
123MP0003890_abnormal_embryonic-extraembry0.68375980
124MP0001299_abnormal_eye_distance/0.67783417
125MP0005167_abnormal_blood-brain_barrier0.67141221
126MP0000751_myopathy0.66745628
127MP0003183_abnormal_peptide_metabolism0.65309369
128MP0001943_abnormal_respiration0.64969575
129MP0003137_abnormal_impulse_conducting0.64756857
130MP0008877_abnormal_DNA_methylation0.63717261
131MP0003948_abnormal_gas_homeostasis0.63080443

Predicted human phenotypes

RankGene SetZ-score
1Absent eyebrow (HP:0002223)7.06762946
2Absent eyelashes (HP:0000561)6.10092561
3Retinal dysplasia (HP:0007973)5.10557324
4Morphological abnormality of the middle ear (HP:0008609)5.03459918
5Bilateral microphthalmos (HP:0007633)4.55895084
6Midline defect of the nose (HP:0004122)4.01852711
7Thyroid-stimulating hormone excess (HP:0002925)3.89088511
8Febrile seizures (HP:0002373)3.84811500
9Atonic seizures (HP:0010819)3.68668467
10Aplasia/Hypoplasia of the brainstem (HP:0007362)3.61976478
11Hypoplasia of the brainstem (HP:0002365)3.61976478
12Split foot (HP:0001839)3.46957781
13Limb dystonia (HP:0002451)3.46756984
14Focal motor seizures (HP:0011153)3.44596720
15Failure to thrive in infancy (HP:0001531)3.40655699
16Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.40257186
17Cortical dysplasia (HP:0002539)3.37916359
18Absent hair (HP:0002298)3.31968391
19Submucous cleft hard palate (HP:0000176)3.28417468
20Type II lissencephaly (HP:0007260)3.27676756
21Absent speech (HP:0001344)3.27456565
22Tented upper lip vermilion (HP:0010804)3.25469657
23Shoulder girdle muscle weakness (HP:0003547)3.20694098
24Ankle clonus (HP:0011448)3.13731763
25Abnormality of the metopic suture (HP:0005556)3.12889926
26Esotropia (HP:0000565)3.11213265
27Prominent metopic ridge (HP:0005487)3.08500520
28Protruding tongue (HP:0010808)3.07454570
29Cutaneous finger syndactyly (HP:0010554)3.01760228
30Thickened helices (HP:0000391)3.00637931
31Amyotrophic lateral sclerosis (HP:0007354)2.99566288
32Epileptic encephalopathy (HP:0200134)2.93676394
33Peripheral hypomyelination (HP:0007182)2.92157845
34Abnormal hair whorl (HP:0010721)2.91906995
35Alveolar cell carcinoma (HP:0006519)2.85373007
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.84106052
37Focal dystonia (HP:0004373)2.82808501
38Spastic tetraplegia (HP:0002510)2.82657639
39Rimmed vacuoles (HP:0003805)2.82501327
40Akinesia (HP:0002304)2.81174741
41Neoplasm of the tracheobronchial system (HP:0100552)2.79093122
42Stereotypic behavior (HP:0000733)2.79054294
43Inability to walk (HP:0002540)2.78514815
44Urinary urgency (HP:0000012)2.77576597
45Lissencephaly (HP:0001339)2.74155713
46Focal seizures (HP:0007359)2.66628051
47Hyperventilation (HP:0002883)2.62512379
48Abnormal gallbladder physiology (HP:0012438)2.55269307
49Cholecystitis (HP:0001082)2.55269307
50Cutaneous syndactyly (HP:0012725)2.54745587
51Abnormality of the aortic arch (HP:0012303)2.52092700
52Myokymia (HP:0002411)2.50831992
53Relative macrocephaly (HP:0004482)2.49660974
54Abnormality of the lacrimal duct (HP:0011481)2.49166706
55Nephrogenic diabetes insipidus (HP:0009806)2.48760165
56Pachygyria (HP:0001302)2.45655084
57Abnormality of the lower motor neuron (HP:0002366)2.44165337
58Spastic gait (HP:0002064)2.43165409
59Large eyes (HP:0001090)2.41361675
60Abnormality of the nasolacrimal system (HP:0000614)2.41227525
61Gastroesophageal reflux (HP:0002020)2.41092889
62Neonatal respiratory distress (HP:0002643)2.40143382
63Hypsarrhythmia (HP:0002521)2.39600754
64Bifid tongue (HP:0010297)2.38640195
65Epileptiform EEG discharges (HP:0011182)2.37776389
66EEG with generalized epileptiform discharges (HP:0011198)2.37085820
67Abnormality of the musculature of the pelvis (HP:0001469)2.36557615
68Abnormality of the hip-girdle musculature (HP:0001445)2.36557615
69Broad alveolar ridges (HP:0000187)2.31901845
70Slow-growing hair (HP:0002217)2.31487233
71Abnormality of hair growth rate (HP:0011363)2.31487233
72Exotropia (HP:0000577)2.31048656
73Amblyopia (HP:0000646)2.29570139
74Polyphagia (HP:0002591)2.29389596
75Patellar aplasia (HP:0006443)2.29286657
76Poor eye contact (HP:0000817)2.29263253
77Absence seizures (HP:0002121)2.27492028
78Unilateral renal agenesis (HP:0000122)2.25246824
79Atrioventricular canal defect (HP:0006695)2.24477336
80Aplasia/Hypoplasia of the sternum (HP:0006714)2.24223919
81Short 4th metacarpal (HP:0010044)2.22769445
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22769445
83Complete atrioventricular canal defect (HP:0001674)2.21851549
84Upper limb muscle weakness (HP:0003484)2.21749788
85Hepatoblastoma (HP:0002884)2.18534569
86Myelomeningocele (HP:0002475)2.18526978
87Anophthalmia (HP:0000528)2.17784637
88Skull defect (HP:0001362)2.15767161
89Wrist flexion contracture (HP:0001239)2.15560283
90Muscular hypotonia of the trunk (HP:0008936)2.13841050
91Pelvic girdle muscle weakness (HP:0003749)2.13695511
92Open mouth (HP:0000194)2.12455460
93Aplasia/Hypoplasia of the patella (HP:0006498)2.11391643
94Hypobetalipoproteinemia (HP:0003563)2.09339962
95Sleep apnea (HP:0010535)2.07967431
96Medial flaring of the eyebrow (HP:0010747)2.07712940
97Mutism (HP:0002300)2.07446382
98Craniofacial dystonia (HP:0012179)2.06747564
99Papillary thyroid carcinoma (HP:0002895)2.05750098
100Prominent supraorbital ridges (HP:0000336)2.04873325
101Abnormality of the corticospinal tract (HP:0002492)2.04784967
102Lower limb muscle weakness (HP:0007340)2.04421626
103Scrotal hypoplasia (HP:0000046)2.03502135
104Congenital primary aphakia (HP:0007707)2.01170362
105Bronchomalacia (HP:0002780)2.01120891
106Narrow nasal bridge (HP:0000446)2.00743814
107Abnormality of the pubic bones (HP:0003172)1.99649253
108Excessive salivation (HP:0003781)1.98285859
109Drooling (HP:0002307)1.98285859
110Action tremor (HP:0002345)1.95292714
111Progressive inability to walk (HP:0002505)1.93664493
112Bulbous nose (HP:0000414)1.92860665
113Progressive cerebellar ataxia (HP:0002073)1.92804397
114Generalized myoclonic seizures (HP:0002123)1.92463190
115Tracheomalacia (HP:0002779)1.91726654
116Status epilepticus (HP:0002133)1.91566249
117Polymicrogyria (HP:0002126)1.91245228
118Septo-optic dysplasia (HP:0100842)1.91220690
119Gonadotropin excess (HP:0000837)1.90647363
120Palpebral edema (HP:0100540)1.90608662
121Small hand (HP:0200055)1.90418566
122Cubitus valgus (HP:0002967)1.90093293
123Truncal ataxia (HP:0002078)1.89465053
124Curly hair (HP:0002212)1.87304450
125Vaginal atresia (HP:0000148)1.87047893
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.86797110
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86797110
128Impulsivity (HP:0100710)1.86752447
129Intention tremor (HP:0002080)1.84521691
130Torticollis (HP:0000473)1.82888502
131Abnormality of the labia minora (HP:0012880)1.82642564
132Optic nerve coloboma (HP:0000588)1.82626482
133Morphological abnormality of the pyramidal tract (HP:0002062)1.82256352
134Genetic anticipation (HP:0003743)1.82218871
135Dialeptic seizures (HP:0011146)1.82111630
136Impaired social interactions (HP:0000735)1.81875062
137Abnormal social behavior (HP:0012433)1.81875062
138Abnormality of glycolysis (HP:0004366)1.81818529
139Dysphonia (HP:0001618)1.81064380
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.80349925
141Intellectual disability, severe (HP:0010864)1.80089618
142Alacrima (HP:0000522)1.79902375
143Agitation (HP:0000713)1.79557995
144Hand muscle atrophy (HP:0009130)1.79307299
145Gait imbalance (HP:0002141)1.78719062
146Limb-girdle muscle weakness (HP:0003325)1.78120682
147Decreased lacrimation (HP:0000633)1.77906896
148Delayed myelination (HP:0012448)1.76446631
149Genital tract atresia (HP:0001827)1.75537090
150Generalized tonic-clonic seizures (HP:0002069)1.75013528
151Abnormality of chromosome segregation (HP:0002916)1.74816099
152Hypoplasia of the corpus callosum (HP:0002079)1.74693012
153Long palpebral fissure (HP:0000637)1.73769911
154Acute necrotizing encephalopathy (HP:0006965)1.73624187
155Broad-based gait (HP:0002136)1.73405292
156Pheochromocytoma (HP:0002666)1.73342094
157Insidious onset (HP:0003587)1.72568230
158Termporal pattern (HP:0011008)1.72568230
159Impaired vibration sensation in the lower limbs (HP:0002166)1.71617287
160Visual hallucinations (HP:0002367)1.71289043
161Downturned corners of mouth (HP:0002714)1.71163681
162Broad distal phalanx of finger (HP:0009836)1.70271450
163Abnormal eating behavior (HP:0100738)1.69398342
164Autism (HP:0000717)1.68762743
165Specific learning disability (HP:0001328)1.67514911
166Poor suck (HP:0002033)1.66056022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.57159737
2EPHA45.05455409
3MARK14.94525101
4MAP4K23.74399261
5BRAF3.18950702
6CASK3.13226493
7TESK22.80685322
8SGK22.72495274
9KSR22.33317019
10TRIM282.30953654
11NTRK32.26690384
12TESK12.18452615
13SIK32.14830429
14MAPK132.09594188
15SGK2232.09338976
16SGK4942.09338976
17MAP2K71.98198435
18SGK31.92663000
19BCKDK1.74629293
20DYRK21.66733399
21RAF11.63915637
22PRPF4B1.62975329
23EPHB21.61852872
24MAP3K41.59658590
25NTRK21.59654966
26MINK11.57837080
27RPS6KA41.57651630
28YES11.49957909
29PRKD31.45686814
30EPHA31.44872556
31PAK31.42872772
32CSNK1G31.38997556
33DAPK21.27745274
34SIK21.23203146
35MAP3K61.12486861
36PHKG21.11196958
37PHKG11.11196958
38MST1R1.10165585
39KSR11.09318261
40SRPK11.07494314
41PRKCH1.03332450
42ERBB31.01202821
43CAMK40.96918961
44TSSK60.94785562
45CDK50.94466197
46CSNK1G10.93576590
47PRKCG0.91736699
48PINK10.90350673
49RPS6KA20.85955527
50PRKD20.85913112
51PIK3CA0.85523627
52LATS20.83477762
53MAP2K40.82569744
54TNIK0.81607544
55TIE10.80329247
56INSRR0.78667989
57TGFBR20.78604262
58BCR0.76239282
59MET0.74414019
60PLK20.73766074
61MKNK20.72680081
62UHMK10.71924686
63CDK190.71893646
64PKN10.69112653
65CDK140.69045202
66ERBB40.67688979
67SCYL20.67561135
68PRKCE0.63328208
69STK160.61992168
70PRKCZ0.61074465
71CDK11A0.60625497
72DYRK1B0.60227980
73SGK10.59073853
74MAP3K120.58475014
75CAMK2A0.58183980
76EIF2AK20.57689663
77DAPK10.56673796
78CAMK10.56522148
79CDK150.56440438
80MARK20.56032779
81BMPR1B0.54926078
82RPS6KL10.54434278
83RPS6KC10.54434278
84RPS6KB10.54137576
85MAPK80.53325677
86ICK0.52629099
87CSNK1G20.50954068
88PRKAA10.50336429
89PDK20.50324543
90LMTK20.49271137
91CCNB10.48504353
92PAK60.46936703
93OXSR10.46484452
94PRKACB0.45531864
95NME10.43836508
96RPS6KA60.43401972
97PLK30.42319079
98PRKD10.41971744
99TAOK30.41187864
100CAMKK10.40188414
101PRKG10.39771941
102ATR0.38754237
103CSNK1A10.37507499
104ROCK10.36926336
105CAMK2B0.36678576
106PRKACA0.36515393
107DYRK1A0.36169231
108PIM20.36034157
109MAP2K10.35980739
110SIK10.35737057
111MAPK100.34841468
112ADRBK10.33663744
113CLK10.33292255
114ROCK20.32446413
115DDR20.32435245
116RPS6KA50.32197035
117ZAK0.32120300
118FES0.32114705
119WNK30.31779703
120PRKCB0.31613309
121MKNK10.31297780
122GRK50.30844812
123RPS6KA30.30609586
124BRD40.30150783
125CSNK1E0.29183610
126GRK70.28896724
127GSK3B0.28213092
128CSNK1D0.28121208
129CAMKK20.27915238
130MAPK120.27731455
131PDGFRA0.27201078
132AKT10.26923452
133PTK2B0.26412732
134SRC0.26029710
135CAMK2G0.26024268
136CSNK1A1L0.25873403
137PAK10.24761631
138MAPK90.24494804
139MAP3K90.24385127
140CDK180.24355010
141LIMK10.24195683
142PRKACG0.24012817
143RPS6KA10.23548510
144CAMK1G0.23066738
145MAPK40.22881922

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.72470425
2GABAergic synapse_Homo sapiens_hsa047272.99355732
3Synaptic vesicle cycle_Homo sapiens_hsa047212.87694254
4Axon guidance_Homo sapiens_hsa043602.66999089
5Morphine addiction_Homo sapiens_hsa050322.65645042
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52857611
7Olfactory transduction_Homo sapiens_hsa047402.34869029
8Circadian entrainment_Homo sapiens_hsa047132.33894079
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32433271
10Glutamatergic synapse_Homo sapiens_hsa047242.04198627
11Serotonergic synapse_Homo sapiens_hsa047261.86875068
12Cholinergic synapse_Homo sapiens_hsa047251.81856856
13Dopaminergic synapse_Homo sapiens_hsa047281.81764380
14Long-term potentiation_Homo sapiens_hsa047201.74380845
15Taste transduction_Homo sapiens_hsa047421.67511750
16Endometrial cancer_Homo sapiens_hsa052131.66400549
17Oxidative phosphorylation_Homo sapiens_hsa001901.64805962
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60997240
19Long-term depression_Homo sapiens_hsa047301.57094258
20Vibrio cholerae infection_Homo sapiens_hsa051101.56055450
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52322890
22Cocaine addiction_Homo sapiens_hsa050301.48471525
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47367263
24Circadian rhythm_Homo sapiens_hsa047101.46831372
25Butanoate metabolism_Homo sapiens_hsa006501.46648292
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45199447
27Type II diabetes mellitus_Homo sapiens_hsa049301.42341352
28ErbB signaling pathway_Homo sapiens_hsa040121.39117215
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35675024
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34752828
31Amphetamine addiction_Homo sapiens_hsa050311.34524318
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33268174
33Oocyte meiosis_Homo sapiens_hsa041141.32941022
34Colorectal cancer_Homo sapiens_hsa052101.29162674
35Arginine biosynthesis_Homo sapiens_hsa002201.27846643
36Lysine degradation_Homo sapiens_hsa003101.24968968
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24580850
38Renin secretion_Homo sapiens_hsa049241.23651060
39Parkinsons disease_Homo sapiens_hsa050121.22889677
40Insulin secretion_Homo sapiens_hsa049111.22409917
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22206105
42Basal cell carcinoma_Homo sapiens_hsa052171.18024766
43cAMP signaling pathway_Homo sapiens_hsa040241.17073655
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15812680
45Oxytocin signaling pathway_Homo sapiens_hsa049211.13387792
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11902224
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11495782
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11156590
49Glioma_Homo sapiens_hsa052141.10215057
50Melanoma_Homo sapiens_hsa052181.09428719
51Gap junction_Homo sapiens_hsa045401.08696147
52Calcium signaling pathway_Homo sapiens_hsa040201.06945780
53Melanogenesis_Homo sapiens_hsa049161.05270198
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04656213
55Renal cell carcinoma_Homo sapiens_hsa052111.01442415
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00521325
57Wnt signaling pathway_Homo sapiens_hsa043100.99667113
58Cardiac muscle contraction_Homo sapiens_hsa042600.99163555
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96486470
60Alzheimers disease_Homo sapiens_hsa050100.95777958
61Hedgehog signaling pathway_Homo sapiens_hsa043400.94166569
62Salivary secretion_Homo sapiens_hsa049700.89400363
63Basal transcription factors_Homo sapiens_hsa030220.89169298
64Huntingtons disease_Homo sapiens_hsa050160.88878854
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85142158
66Phototransduction_Homo sapiens_hsa047440.84963944
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84447033
68Sulfur relay system_Homo sapiens_hsa041220.84133406
69RNA polymerase_Homo sapiens_hsa030200.83136706
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.82343031
71AMPK signaling pathway_Homo sapiens_hsa041520.81821367
72Collecting duct acid secretion_Homo sapiens_hsa049660.80512581
73Regulation of autophagy_Homo sapiens_hsa041400.80196668
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80050221
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78947130
76Selenocompound metabolism_Homo sapiens_hsa004500.78186848
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77855067
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77257299
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76942987
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76847303
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76688701
82Salmonella infection_Homo sapiens_hsa051320.76231044
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75487963
84Fatty acid elongation_Homo sapiens_hsa000620.73388541
85Shigellosis_Homo sapiens_hsa051310.69042163
86Alcoholism_Homo sapiens_hsa050340.68699250
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68476317
88Type I diabetes mellitus_Homo sapiens_hsa049400.66741805
89Phenylalanine metabolism_Homo sapiens_hsa003600.66108233
90Ras signaling pathway_Homo sapiens_hsa040140.65174319
91Rap1 signaling pathway_Homo sapiens_hsa040150.64898541
92Estrogen signaling pathway_Homo sapiens_hsa049150.64716593
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63751002
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62723469
95mRNA surveillance pathway_Homo sapiens_hsa030150.62319269
96Insulin signaling pathway_Homo sapiens_hsa049100.62296733
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.61722103
98Propanoate metabolism_Homo sapiens_hsa006400.61678418
99Acute myeloid leukemia_Homo sapiens_hsa052210.61047467
100Endocytosis_Homo sapiens_hsa041440.60996825
101Gastric acid secretion_Homo sapiens_hsa049710.60710305
102beta-Alanine metabolism_Homo sapiens_hsa004100.60611217
103mTOR signaling pathway_Homo sapiens_hsa041500.60324436
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60218762
105Non-small cell lung cancer_Homo sapiens_hsa052230.59958701
106Sulfur metabolism_Homo sapiens_hsa009200.59796400
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59550573
108Carbon metabolism_Homo sapiens_hsa012000.59367840
109Pyruvate metabolism_Homo sapiens_hsa006200.58591640
110Prostate cancer_Homo sapiens_hsa052150.58210446
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57105081
112MAPK signaling pathway_Homo sapiens_hsa040100.56522969
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55313216
114Spliceosome_Homo sapiens_hsa030400.54796621
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54007629
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53295303
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52564591
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52129785
119Purine metabolism_Homo sapiens_hsa002300.51693328
120Protein export_Homo sapiens_hsa030600.51238559
121Ether lipid metabolism_Homo sapiens_hsa005650.49722172
122GnRH signaling pathway_Homo sapiens_hsa049120.49501167
123Ovarian steroidogenesis_Homo sapiens_hsa049130.48667944
124Fatty acid metabolism_Homo sapiens_hsa012120.48448778
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48185545
126Peroxisome_Homo sapiens_hsa041460.45638024
127RNA degradation_Homo sapiens_hsa030180.44903450
128ABC transporters_Homo sapiens_hsa020100.44627361
129Notch signaling pathway_Homo sapiens_hsa043300.42771796
130Hippo signaling pathway_Homo sapiens_hsa043900.42713415
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42058914
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42053820
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41709267
134Dilated cardiomyopathy_Homo sapiens_hsa054140.41688763
135Chemokine signaling pathway_Homo sapiens_hsa040620.41123897
136Prolactin signaling pathway_Homo sapiens_hsa049170.40615955
137Base excision repair_Homo sapiens_hsa034100.40101930
138Phagosome_Homo sapiens_hsa041450.39268726
139Pancreatic cancer_Homo sapiens_hsa052120.38888726
140Choline metabolism in cancer_Homo sapiens_hsa052310.38795872
141Fatty acid biosynthesis_Homo sapiens_hsa000610.37937962
142Tight junction_Homo sapiens_hsa045300.37842870
143PPAR signaling pathway_Homo sapiens_hsa033200.37525664
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36506166
145Prion diseases_Homo sapiens_hsa050200.35328980
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.34686532
147Glucagon signaling pathway_Homo sapiens_hsa049220.32041599
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30280936
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29004599

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