LHX9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.44241489
2parturition (GO:0007567)5.88029818
3ovulation cycle (GO:0042698)5.79924615
4protein localization to cilium (GO:0061512)5.37292812
5nucleobase catabolic process (GO:0046113)5.02983899
6sequestering of actin monomers (GO:0042989)4.95261356
7auditory behavior (GO:0031223)4.81114392
8gonadal mesoderm development (GO:0007506)4.76690744
9establishment of mitochondrion localization (GO:0051654)4.73283201
10negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.67220777
11mitochondrion transport along microtubule (GO:0047497)4.64492030
12establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.64492030
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.43603012
14synaptic transmission, cholinergic (GO:0007271)4.21481260
15regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.14395950
16neuron recognition (GO:0008038)4.05904714
17embryonic forelimb morphogenesis (GO:0035115)3.95532602
18negative regulation of axon extension involved in axon guidance (GO:0048843)3.93974099
19postsynaptic membrane organization (GO:0001941)3.91178019
20forelimb morphogenesis (GO:0035136)3.88625207
21neuron cell-cell adhesion (GO:0007158)3.88532194
22presynaptic membrane assembly (GO:0097105)3.85431672
23synapse assembly (GO:0007416)3.84271031
24axonal fasciculation (GO:0007413)3.83262211
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.82563725
26cerebral cortex radially oriented cell migration (GO:0021799)3.77867524
27negative regulation of axon guidance (GO:1902668)3.73887609
28presynaptic membrane organization (GO:0097090)3.71841348
29mechanosensory behavior (GO:0007638)3.66785760
30central nervous system projection neuron axonogenesis (GO:0021952)3.62557934
31regulation of respiratory system process (GO:0044065)3.56940523
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.50363305
33neuron projection extension (GO:1990138)3.50294795
34embryonic skeletal joint morphogenesis (GO:0060272)3.44945326
35regulation of respiratory gaseous exchange (GO:0043576)3.42783176
36heparin biosynthetic process (GO:0030210)3.42278009
37heparin metabolic process (GO:0030202)3.42278009
38regulation of vesicle fusion (GO:0031338)3.39102945
39mesenchymal cell differentiation involved in renal system development (GO:2001012)3.37299475
40mesenchymal cell differentiation involved in kidney development (GO:0072161)3.37299475
41transmission of nerve impulse (GO:0019226)3.35023240
42neurofilament cytoskeleton organization (GO:0060052)3.34627753
43negative regulation of microtubule polymerization (GO:0031115)3.31079756
44neuromuscular synaptic transmission (GO:0007274)3.29963869
45vocalization behavior (GO:0071625)3.29359188
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.27715707
47metanephric mesenchyme development (GO:0072075)3.27123601
48regulation of glutamate receptor signaling pathway (GO:1900449)3.24876062
49neuron migration (GO:0001764)3.24806363
50opioid receptor signaling pathway (GO:0038003)3.23458383
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22908405
52neural tube formation (GO:0001841)3.21131980
53ganglion development (GO:0061548)3.20550704
54dendritic spine morphogenesis (GO:0060997)3.20312246
55regulation of male gonad development (GO:2000018)3.18833209
56lateral sprouting from an epithelium (GO:0060601)3.17220451
57regulation of axon extension involved in axon guidance (GO:0048841)3.15663171
58limb bud formation (GO:0060174)3.14563618
59olfactory bulb development (GO:0021772)3.13746782
60neurotransmitter-gated ion channel clustering (GO:0072578)3.12183993
61regulation of non-canonical Wnt signaling pathway (GO:2000050)3.12070979
62regulation of axon guidance (GO:1902667)3.11879080
63proximal/distal pattern formation (GO:0009954)3.11321148
64cranial nerve morphogenesis (GO:0021602)3.10401662
65cardiac ventricle formation (GO:0003211)3.10283970
66substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.09736264
67substrate-independent telencephalic tangential migration (GO:0021826)3.09736264
68positive regulation of synapse assembly (GO:0051965)3.09657760
69glutamate receptor signaling pathway (GO:0007215)3.07429338
70regulation of mesenchymal cell apoptotic process (GO:2001053)3.07399429
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06669145
72regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.05834561
73regulation of dopamine secretion (GO:0014059)3.03019407
74positive regulation of male gonad development (GO:2000020)3.02122936
75regulation of type B pancreatic cell apoptotic process (GO:2000674)3.01747451
76regulation of synapse assembly (GO:0051963)2.99557073
77neuronal ion channel clustering (GO:0045161)2.99373841
78response to auditory stimulus (GO:0010996)2.98718401
79protein localization to synapse (GO:0035418)2.96548761
80neuron projection extension involved in neuron projection guidance (GO:1902284)2.95602637
81axon extension involved in axon guidance (GO:0048846)2.95602637
82calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.95595521
83cerebellar Purkinje cell differentiation (GO:0021702)2.95524476
84negative chemotaxis (GO:0050919)2.92723345
85sympathetic nervous system development (GO:0048485)2.92367995
86central nervous system neuron axonogenesis (GO:0021955)2.91929114
87kidney mesenchyme development (GO:0072074)2.91602978
88polyketide metabolic process (GO:0030638)2.90746756
89doxorubicin metabolic process (GO:0044598)2.90746756
90daunorubicin metabolic process (GO:0044597)2.90746756
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90567921
92detection of temperature stimulus involved in sensory perception (GO:0050961)2.90565657
93detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.90565657
94negative regulation of axonogenesis (GO:0050771)2.90457401
95positive regulation of dendritic spine morphogenesis (GO:0061003)2.88169613
96adult walking behavior (GO:0007628)2.87953584
97cell differentiation involved in kidney development (GO:0061005)2.85574158
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85451323
99regulation of collateral sprouting (GO:0048670)2.85157949
100layer formation in cerebral cortex (GO:0021819)2.85150581
101short-term memory (GO:0007614)2.83570899
102sequestering of extracellular ligand from receptor (GO:0035581)2.83126552
103cardiac chamber formation (GO:0003207)2.83000751
104cerebellum development (GO:0021549)2.81445996
105extracellular negative regulation of signal transduction (GO:1900116)2.80050631
106extracellular regulation of signal transduction (GO:1900115)2.80050631
107synapse organization (GO:0050808)2.79183977
108glomerulus development (GO:0032835)2.78468457
109regulation of pigment cell differentiation (GO:0050932)2.78354223
110branching involved in prostate gland morphogenesis (GO:0060442)2.78251980
111endoderm formation (GO:0001706)2.77046159
112head development (GO:0060322)2.76864113
113dendrite morphogenesis (GO:0048813)2.76515353
114synaptic transmission, glutamatergic (GO:0035249)2.76333621
115cell migration in hindbrain (GO:0021535)2.76252431
116positive regulation of gastrulation (GO:2000543)2.76028318
117facial nerve structural organization (GO:0021612)2.74378935
118regulation of synaptic vesicle exocytosis (GO:2000300)2.74006621
119kidney morphogenesis (GO:0060993)2.73397543
120positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72195801
121axonogenesis (GO:0007409)2.72002960
122startle response (GO:0001964)2.71919290
123embryonic appendage morphogenesis (GO:0035113)2.71380709
124embryonic limb morphogenesis (GO:0030326)2.71380709
125cell differentiation involved in metanephros development (GO:0072202)2.70604655
126regulation of extent of cell growth (GO:0061387)2.70276140
127prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.69244106
128embryonic digit morphogenesis (GO:0042733)2.68849742
129secondary heart field specification (GO:0003139)2.67576498
130heart field specification (GO:0003128)2.67576498
131cerebral cortex cell migration (GO:0021795)2.67283360
132righting reflex (GO:0060013)2.67007350
133urogenital system development (GO:0001655)2.66399547
134inner ear receptor stereocilium organization (GO:0060122)2.65968238
135cell-cell junction maintenance (GO:0045217)2.65590759
136positive regulation of neurotransmitter transport (GO:0051590)2.65587174
137limb morphogenesis (GO:0035108)2.65344276
138appendage morphogenesis (GO:0035107)2.65344276
139regulation of synapse organization (GO:0050807)2.65053525
140negative regulation of osteoblast proliferation (GO:0033689)2.64758936
141bone trabecula formation (GO:0060346)2.64519542
142adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.63726416
143regulation of axon extension (GO:0030516)2.61198844
144nervous system development (GO:0007399)2.59816887
145negative regulation of axon extension (GO:0030517)2.58677981
146regulation of synaptic vesicle transport (GO:1902803)2.58080375
147spinal cord development (GO:0021510)2.58073757
148pyrimidine nucleobase catabolic process (GO:0006208)2.57636034
149heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.57514924
150retinal ganglion cell axon guidance (GO:0031290)2.57431656
151cranial nerve structural organization (GO:0021604)2.55264262
152uterus development (GO:0060065)2.54094371
153peripheral nervous system neuron development (GO:0048935)2.53498924
154neuron remodeling (GO:0016322)2.52277796
155synaptic vesicle docking involved in exocytosis (GO:0016081)2.51461273
156embryonic digestive tract morphogenesis (GO:0048557)2.51009943
157positive regulation of smoothened signaling pathway (GO:0045880)2.50385802
158negative regulation of dendrite development (GO:2000171)2.47920830
159serotonin receptor signaling pathway (GO:0007210)2.47653958
160mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.45784215
161dendrite development (GO:0016358)2.45451091
162establishment of nucleus localization (GO:0040023)2.44024141
163generation of neurons (GO:0048699)2.43841740
164neuron-neuron synaptic transmission (GO:0007270)2.43599122
165axon extension (GO:0048675)2.42792966
166positive regulation of meiosis (GO:0045836)2.42420688
167cell proliferation in forebrain (GO:0021846)2.42249094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.87444558
2GBX2_23144817_ChIP-Seq_PC3_Human3.81889900
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.05044031
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97606428
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.95154727
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83353138
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.83079774
8* CBX2_27304074_Chip-Seq_ESCs_Mouse2.72547876
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66691113
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65205828
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63520585
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57796092
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57796092
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50298469
15* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.48121375
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45279709
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42119083
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33102082
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.26890130
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18139295
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.15544648
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05821066
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.96890328
24* RNF2_27304074_Chip-Seq_NSC_Mouse1.93743429
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93586122
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92944545
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91982133
28P300_19829295_ChIP-Seq_ESCs_Human1.91953753
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91040825
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85994974
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82749621
32ZNF274_21170338_ChIP-Seq_K562_Hela1.79639092
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78713537
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75116630
35IGF1R_20145208_ChIP-Seq_DFB_Human1.74573725
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74340374
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61719924
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61226646
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59422094
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58656870
41FUS_26573619_Chip-Seq_HEK293_Human1.58144570
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57843504
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.57190471
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57039114
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56563059
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55491921
47CBP_20019798_ChIP-Seq_JUKART_Human1.55491921
48REST_21632747_ChIP-Seq_MESCs_Mouse1.54909449
49TAF15_26573619_Chip-Seq_HEK293_Human1.52397245
50SMAD4_21799915_ChIP-Seq_A2780_Human1.51559963
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48880831
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.47350723
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47287023
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.47127323
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43474864
56VDR_22108803_ChIP-Seq_LS180_Human1.42438095
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41235885
58* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41072318
59DROSHA_22980978_ChIP-Seq_HELA_Human1.40221050
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39231088
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.38303915
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.37518660
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.35979830
64* NANOG_18555785_Chip-Seq_ESCs_Mouse1.35210248
65TP53_18474530_ChIP-ChIP_U2OS_Human1.35023146
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35003294
67* TP53_20018659_ChIP-ChIP_R1E_Mouse1.33845656
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32647741
69* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31748223
70* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31392501
71* E2F1_18555785_Chip-Seq_ESCs_Mouse1.31144938
72* EWS_26573619_Chip-Seq_HEK293_Human1.30626696
73AR_21572438_ChIP-Seq_LNCaP_Human1.29674766
74* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28781926
75ER_23166858_ChIP-Seq_MCF-7_Human1.27695953
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27504503
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27006472
78* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26519672
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25873001
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25873001
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24959598
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.24258357
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.22998418
84* P53_22387025_ChIP-Seq_ESCs_Mouse1.21445679
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20987223
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.18884872
87* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18610853
88AR_25329375_ChIP-Seq_VCAP_Human1.18044519
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17384597
90RUNX2_22187159_ChIP-Seq_PCA_Human1.17094928
91STAT3_23295773_ChIP-Seq_U87_Human1.16976603
92* CMYC_18555785_Chip-Seq_ESCs_Mouse1.16053646
93* NFE2_27457419_Chip-Seq_LIVER_Mouse1.15834645
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15652934
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.15194724
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14575791
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14501696
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14354101
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13150248
100* EZH2_27294783_Chip-Seq_NPCs_Mouse1.13134093
101JUN_21703547_ChIP-Seq_K562_Human1.12373551
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11283377
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10682355
104* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10630140
105AHR_22903824_ChIP-Seq_MCF-7_Human1.10215720
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10102896
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.07376398
108* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07045306
109* P300_18555785_Chip-Seq_ESCs_Mouse1.06441576
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06097288
111ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05780917
112TCF4_23295773_ChIP-Seq_U87_Human1.05670720
113RARB_27405468_Chip-Seq_BRAIN_Mouse1.04762944
114* STAT3_18555785_Chip-Seq_ESCs_Mouse1.03762011
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03470453
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02994666
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01016351
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99607328
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.99247405
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97596000
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95120779
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.93016633
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.92493201
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92053823
125* AR_19668381_ChIP-Seq_PC3_Human0.91308814
126* SOX9_26525672_Chip-Seq_HEART_Mouse0.90123598
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89415218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.36055810
2MP0003880_abnormal_central_pattern4.43380398
3MP0009053_abnormal_anal_canal3.32502086
4MP0003122_maternal_imprinting2.77813451
5MP0006292_abnormal_olfactory_placode2.47429291
6MP0004859_abnormal_synaptic_plasticity2.41300077
7MP0003315_abnormal_perineum_morphology2.39004931
8MP0002653_abnormal_ependyma_morphology2.28737895
9MP0003787_abnormal_imprinting2.27833344
10MP0005423_abnormal_somatic_nervous2.27149855
11MP0001188_hyperpigmentation2.27097655
12MP0000566_synostosis2.26924371
13MP0000778_abnormal_nervous_system2.25568944
14MP0003385_abnormal_body_wall2.19071593
15MP0000537_abnormal_urethra_morphology2.13393786
16MP0005645_abnormal_hypothalamus_physiol2.11192882
17MP0005187_abnormal_penis_morphology2.04403187
18MP0004145_abnormal_muscle_electrophysio2.03513352
19MP0009250_abnormal_appendicular_skeleto2.02231400
20MP0006276_abnormal_autonomic_nervous2.01864215
21MP0002184_abnormal_innervation2.00286755
22MP0002938_white_spotting1.97429289
23MP0005503_abnormal_tendon_morphology1.96687219
24MP0003635_abnormal_synaptic_transmissio1.91915748
25MP0002102_abnormal_ear_morphology1.90593686
26MP0003121_genomic_imprinting1.85514256
27MP0009745_abnormal_behavioral_response1.73947014
28MP0005248_abnormal_Harderian_gland1.67324468
29MP0010030_abnormal_orbit_morphology1.65360332
30MP0002063_abnormal_learning/memory/cond1.65229614
31MP0004133_heterotaxia1.65203452
32MP0001486_abnormal_startle_reflex1.64689052
33MP0003942_abnormal_urinary_system1.63021039
34MP0005171_absent_coat_pigmentation1.61602946
35MP0003937_abnormal_limbs/digits/tail_de1.60246884
36MP0003941_abnormal_skin_development1.60080291
37MP0004742_abnormal_vestibular_system1.59717729
38MP0001968_abnormal_touch/_nociception1.59256092
39MP0002557_abnormal_social/conspecific_i1.58616184
40MP0003123_paternal_imprinting1.58342282
41MP0000049_abnormal_middle_ear1.57043971
42MP0001905_abnormal_dopamine_level1.54859936
43MP0002572_abnormal_emotion/affect_behav1.52345734
44MP0000631_abnormal_neuroendocrine_gland1.51476418
45MP0002928_abnormal_bile_duct1.49061524
46MP0005646_abnormal_pituitary_gland1.47390754
47MP0001727_abnormal_embryo_implantation1.46361011
48MP0001501_abnormal_sleep_pattern1.46054732
49MP0003136_yellow_coat_color1.44667209
50MP0004811_abnormal_neuron_physiology1.43735292
51MP0002735_abnormal_chemical_nociception1.40586019
52MP0005386_behavior/neurological_phenoty1.39838473
53MP0004924_abnormal_behavior1.39838473
54MP0002734_abnormal_mechanical_nocicepti1.38198798
55MP0002249_abnormal_larynx_morphology1.34489352
56MP0002736_abnormal_nociception_after1.30604406
57MP0005551_abnormal_eye_electrophysiolog1.30248100
58MP0002064_seizures1.30015740
59MP0001324_abnormal_eye_pigmentation1.29984614
60MP0000647_abnormal_sebaceous_gland1.29198677
61MP0008877_abnormal_DNA_methylation1.28652930
62MP0002272_abnormal_nervous_system1.28594772
63MP0005367_renal/urinary_system_phenotyp1.26689797
64MP0000516_abnormal_urinary_system1.26689797
65MP0004270_analgesia1.26440609
66MP0002233_abnormal_nose_morphology1.24234456
67MP0010386_abnormal_urinary_bladder1.23906541
68MP0002067_abnormal_sensory_capabilities1.22635197
69MP0003755_abnormal_palate_morphology1.22624835
70MP0003938_abnormal_ear_development1.22509391
71MP0008789_abnormal_olfactory_epithelium1.21912890
72MP0002751_abnormal_autonomic_nervous1.20754495
73MP0005394_taste/olfaction_phenotype1.19063689
74MP0005499_abnormal_olfactory_system1.19063689
75MP0001502_abnormal_circadian_rhythm1.17850818
76MP0000026_abnormal_inner_ear1.17215138
77MP0002177_abnormal_outer_ear1.15022100
78MP0009046_muscle_twitch1.14436802
79MP0002282_abnormal_trachea_morphology1.14337709
80MP0001984_abnormal_olfaction1.13661743
81MP0002116_abnormal_craniofacial_bone1.10775137
82MP0002932_abnormal_joint_morphology1.09285425
83MP0005195_abnormal_posterior_eye1.09279679
84MP0003861_abnormal_nervous_system1.09228289
85MP0000955_abnormal_spinal_cord1.08385755
86MP0005257_abnormal_intraocular_pressure1.04808273
87MP0004142_abnormal_muscle_tone1.04748030
88MP0003879_abnormal_hair_cell1.02864722
89MP0002882_abnormal_neuron_morphology1.02068720
90MP0002109_abnormal_limb_morphology0.99714676
91MP0008995_early_reproductive_senescence0.98622852
92MP0002638_abnormal_pupillary_reflex0.98093148
93MP0003890_abnormal_embryonic-extraembry0.97442242
94MP0009697_abnormal_copulation0.96709383
95MP0002066_abnormal_motor_capabilities/c0.96326539
96MP0005253_abnormal_eye_physiology0.96307936
97MP0002909_abnormal_adrenal_gland0.94527606
98MP0002163_abnormal_gland_morphology0.94040965
99MP0001440_abnormal_grooming_behavior0.93235705
100MP0000015_abnormal_ear_pigmentation0.92862049
101MP0001963_abnormal_hearing_physiology0.92814410
102MP0001346_abnormal_lacrimal_gland0.92592083
103MP0001286_abnormal_eye_development0.91164424
104MP0002152_abnormal_brain_morphology0.90347527
105MP0001485_abnormal_pinna_reflex0.89158086
106MP0003633_abnormal_nervous_system0.88617692
107MP0000428_abnormal_craniofacial_morphol0.87931818
108MP0003137_abnormal_impulse_conducting0.87896129
109MP0001529_abnormal_vocalization0.86820967
110MP0001177_atelectasis0.86522512
111MP0003935_abnormal_craniofacial_develop0.86096929
112MP0002752_abnormal_somatic_nervous0.85909685
113MP0005197_abnormal_uvea_morphology0.85857466
114MP0002115_abnormal_skeleton_extremities0.85187705
115MP0002277_abnormal_respiratory_mucosa0.84103607
116MP0001970_abnormal_pain_threshold0.83574648
117MP0008569_lethality_at_weaning0.83030323
118MP0002733_abnormal_thermal_nociception0.82694257
119MP0005409_darkened_coat_color0.82083255
120MP0002114_abnormal_axial_skeleton0.81551793
121MP0000538_abnormal_urinary_bladder0.80702277
122MP0000534_abnormal_ureter_morphology0.80538756
123MP0002876_abnormal_thyroid_physiology0.80117338
124MP0006072_abnormal_retinal_apoptosis0.79142557
125MP0002697_abnormal_eye_size0.78695023
126MP0002081_perinatal_lethality0.77042729
127MP0002229_neurodegeneration0.73580581
128MP0002069_abnormal_eating/drinking_beha0.70498044
129MP0004147_increased_porphyrin_level0.69257769
130* MP0003698_abnormal_male_reproductive0.64349755
131MP0010770_preweaning_lethality0.63915595
132MP0002082_postnatal_lethality0.63915595
133MP0000427_abnormal_hair_cycle0.61653093
134MP0003119_abnormal_digestive_system0.61131704
135MP0004885_abnormal_endolymph0.60815092

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.64537160
2Abnormality of the corticospinal tract (HP:0002492)4.57414669
3Short middle phalanx of the 5th finger (HP:0004220)4.20662020
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.86019035
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.86019035
6Mesomelia (HP:0003027)3.78770665
7Agitation (HP:0000713)3.75788597
8Abnormality of the phalanges of the hallux (HP:0010057)3.70895632
9Polyphagia (HP:0002591)3.55665692
10Pachygyria (HP:0001302)3.48197697
11Cortical dysplasia (HP:0002539)3.43035318
12Cutaneous finger syndactyly (HP:0010554)3.39691334
13Asymmetry of the thorax (HP:0001555)3.38169918
14Poor suck (HP:0002033)3.37332147
15Limb dystonia (HP:0002451)3.36535506
16Focal motor seizures (HP:0011153)3.31691733
17Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.30983802
18Impaired vibration sensation in the lower limbs (HP:0002166)3.30931098
19Lissencephaly (HP:0001339)3.20959332
20Genetic anticipation (HP:0003743)3.16939220
21Drooling (HP:0002307)3.14737025
22Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.11996878
23Abnormality of the phalanges of the 5th finger (HP:0004213)3.09413931
24Febrile seizures (HP:0002373)3.07350834
25Abnormality of the lower motor neuron (HP:0002366)3.03470894
26Abnormality of the 4th metacarpal (HP:0010012)3.01069656
27Abnormality of midbrain morphology (HP:0002418)3.00338471
28Molar tooth sign on MRI (HP:0002419)3.00338471
29Nephronophthisis (HP:0000090)2.99099379
30Short 5th finger (HP:0009237)2.98276427
31Papilledema (HP:0001085)2.95365979
32Aplasia/Hypoplasia of the brainstem (HP:0007362)2.92872483
33Hypoplasia of the brainstem (HP:0002365)2.92872483
34Cutaneous syndactyly (HP:0012725)2.90768957
35Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.88414271
36Excessive salivation (HP:0003781)2.88045082
37Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.86006089
38Fibular aplasia (HP:0002990)2.79872711
39Focal seizures (HP:0007359)2.77704085
40Gait imbalance (HP:0002141)2.76590707
41Generalized aminoaciduria (HP:0002909)2.59403062
42Morphological abnormality of the pyramidal tract (HP:0002062)2.59037942
43Amblyopia (HP:0000646)2.58813685
44True hermaphroditism (HP:0010459)2.58000156
45Renal cortical cysts (HP:0000803)2.56737707
46Pancreatic fibrosis (HP:0100732)2.53579887
47Morphological abnormality of the middle ear (HP:0008609)2.53433587
48Oligodactyly (hands) (HP:0001180)2.52810645
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51548046
50Urinary urgency (HP:0000012)2.51373365
51Septo-optic dysplasia (HP:0100842)2.51344399
52Renal dysplasia (HP:0000110)2.49567769
53Occipital encephalocele (HP:0002085)2.49211659
54Chronic hepatic failure (HP:0100626)2.47435321
55Retinal dysplasia (HP:0007973)2.46630355
56Broad distal phalanx of finger (HP:0009836)2.46547975
57Medial flaring of the eyebrow (HP:0010747)2.45892393
58Pancreatic cysts (HP:0001737)2.42486271
59Abnormality of the renal medulla (HP:0100957)2.40419328
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.39450915
61Absent/shortened dynein arms (HP:0200106)2.33641999
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.33641999
63Abnormality of the middle phalanges of the toes (HP:0010183)2.30663638
64Urinary bladder sphincter dysfunction (HP:0002839)2.26930843
65Paraplegia (HP:0010550)2.26854938
66Microglossia (HP:0000171)2.24312602
67Inappropriate behavior (HP:0000719)2.23756155
68Turricephaly (HP:0000262)2.23544899
69Renal duplication (HP:0000075)2.23388550
70Short 4th metacarpal (HP:0010044)2.22840423
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22840423
72Midline defect of the nose (HP:0004122)2.22835423
73Absent phalangeal crease (HP:0006109)2.20310209
74Congenital primary aphakia (HP:0007707)2.19942781
75Epileptic encephalopathy (HP:0200134)2.18540668
76Abnormality of the renal cortex (HP:0011035)2.17581882
77Progressive cerebellar ataxia (HP:0002073)2.17552077
78Abnormality of incisor morphology (HP:0011063)2.15729498
79Polymicrogyria (HP:0002126)2.15656006
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14892345
81Ectopic kidney (HP:0000086)2.14697524
82Protruding tongue (HP:0010808)2.14182937
83Abnormality of the 2nd finger (HP:0004100)2.12604305
84Abnormal pancreas size (HP:0012094)2.11560801
85Heterochromia iridis (HP:0001100)2.10431156
86Short middle phalanx of finger (HP:0005819)2.09119317
87Labial hypoplasia (HP:0000066)2.06440563
88Abnormality of dentin (HP:0010299)2.04286978
89Bell-shaped thorax (HP:0001591)2.02528363
90Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.00294995
91Type 2 muscle fiber atrophy (HP:0003554)1.99726633
92Hepatoblastoma (HP:0002884)1.99072634
93Abnormal finger flexion creases (HP:0006143)1.98664584
94Optic nerve hypoplasia (HP:0000609)1.98591016
95Vaginal atresia (HP:0000148)1.98081024
96Myotonia (HP:0002486)1.97879544
97Nephrogenic diabetes insipidus (HP:0009806)1.97813910
98Omphalocele (HP:0001539)1.97413282
99Ureteral stenosis (HP:0000071)1.97028894
100Parakeratosis (HP:0001036)1.96999029
101Failure to thrive in infancy (HP:0001531)1.96949223
102Abnormal ciliary motility (HP:0012262)1.95185542
103Bony spicule pigmentary retinopathy (HP:0007737)1.95133419
104Congenital sensorineural hearing impairment (HP:0008527)1.94921892
105Genital tract atresia (HP:0001827)1.93792734
106Follicular hyperkeratosis (HP:0007502)1.92683744
107Aplasia of the musculature (HP:0100854)1.92643003
108Decreased muscle mass (HP:0003199)1.92223963
109Widely spaced teeth (HP:0000687)1.92036490
110Lower limb muscle weakness (HP:0007340)1.91752944
111Spastic paraplegia (HP:0001258)1.91374917
112Abnormal eating behavior (HP:0100738)1.91276650
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.90969862
114Restlessness (HP:0000711)1.89888988
115Myelomeningocele (HP:0002475)1.89667135
116Wrist flexion contracture (HP:0001239)1.89388792
117Spastic gait (HP:0002064)1.89155127
118Akinesia (HP:0002304)1.88655479
119Abnormality of the intervertebral disk (HP:0005108)1.87805716
120Ureteral obstruction (HP:0006000)1.87053451
121Preaxial hand polydactyly (HP:0001177)1.86802045
122Type II lissencephaly (HP:0007260)1.86325318
123Increased corneal curvature (HP:0100692)1.86066043
124Keratoconus (HP:0000563)1.86066043
125Increased number of teeth (HP:0011069)1.85923470
126Cystic liver disease (HP:0006706)1.85820216
127Abnormal respiratory motile cilium physiology (HP:0012261)1.85282934
128Hypoplastic female external genitalia (HP:0012815)1.83946768
129Esotropia (HP:0000565)1.83940258
130Deviation of the hallux (HP:0010051)1.83731121
131Intellectual disability, severe (HP:0010864)1.83644502
132Embryonal renal neoplasm (HP:0011794)1.82950822
133Carpal synostosis (HP:0009702)1.82134431
134Short metatarsal (HP:0010743)1.80758509
135Abnormality of the labia minora (HP:0012880)1.80711495
136Shawl scrotum (HP:0000049)1.79797834
137Abnormality of the parietal bone (HP:0002696)1.79711462
138Synostosis involving bones of the hand (HP:0004278)1.79686469
139Postaxial foot polydactyly (HP:0001830)1.78404354
140Intellectual disability, moderate (HP:0002342)1.78225781
141Narrow nasal bridge (HP:0000446)1.77469614
142Nephroblastoma (Wilms tumor) (HP:0002667)1.77299562
143Tented upper lip vermilion (HP:0010804)1.77090818
144Palpebral edema (HP:0100540)1.76729222
145Atrophy/Degeneration involving motor neurons (HP:0007373)1.76004774
146Inability to walk (HP:0002540)1.75786720
147Proximal tubulopathy (HP:0000114)1.74948482
148Narrow forehead (HP:0000341)1.74790330
149Spastic tetraplegia (HP:0002510)1.74737886
150Exotropia (HP:0000577)1.73749242
151Osteomalacia (HP:0002749)1.73102562
152Broad-based gait (HP:0002136)1.72027449
153Short clavicles (HP:0000894)1.71966519
154Hyperventilation (HP:0002883)1.70529971
155Abnormal umbilical cord blood vessels (HP:0011403)1.70171136
156Single umbilical artery (HP:0001195)1.70171136
157Abnormality of the fetal cardiovascular system (HP:0010948)1.70171136
158Optic disc pallor (HP:0000543)1.69118259
159Coronal craniosynostosis (HP:0004440)1.69014999
160Peripheral hypomyelination (HP:0007182)1.68771124
161Aplasia/Hypoplasia of the clavicles (HP:0006710)1.68704924
162Male pseudohermaphroditism (HP:0000037)1.68663998
163Preaxial foot polydactyly (HP:0001841)1.68541828
164Atonic seizures (HP:0010819)1.68346600
165Highly arched eyebrow (HP:0002553)1.68204808
166Abnormal sex determination (HP:0012244)1.68039330
167Sex reversal (HP:0012245)1.68039330
168Incomplete penetrance (HP:0003829)1.67140022
169Absent eyebrow (HP:0002223)1.66549608
170Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66491383
171Sleep apnea (HP:0010535)1.65911855
172Abnormality of the right ventricle (HP:0001707)1.65783635
173Specific learning disability (HP:0001328)1.65312727
174Thyroid-stimulating hormone excess (HP:0002925)1.64358605
175Aplasia/Hypoplasia of the fibula (HP:0006492)1.63931583
176Synostosis of carpal bones (HP:0005048)1.63704663
177Abnormality of the middle phalanges of the hand (HP:0009833)1.62666033
178Absent speech (HP:0001344)1.62112923
179Fetal akinesia sequence (HP:0001989)1.61423435
180Absent septum pellucidum (HP:0001331)1.60096915
181Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.59699428
182Short 1st metacarpal (HP:0010034)1.59699428
183Anencephaly (HP:0002323)1.57565603
184Broad finger (HP:0001500)1.57458751
185Small hand (HP:0200055)1.57381878
186Patellar dislocation (HP:0002999)1.56327749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.46176067
2TNIK3.74637506
3MARK13.36409650
4SIK33.04794320
5ERBB32.98569150
6MAPK132.95266652
7NTRK32.87997046
8MAP2K72.77894808
9MKNK22.64075466
10DYRK32.47340208
11SIK22.21527606
12MKNK12.21002529
13NLK2.08747279
14NTRK22.01996572
15PRPF4B2.01559474
16EPHB21.82455244
17MAP3K41.81694334
18YES11.78747999
19SRPK11.67822750
20PKN21.64986356
21UHMK11.64557115
22MAP3K121.52210637
23ZAK1.51202682
24EPHA41.50211859
25EPHA31.40734867
26LATS21.35024851
27BCR1.33768689
28PLK21.32903864
29EIF2AK21.32627759
30DDR21.26508713
31LATS11.26060080
32PINK11.23495162
33DMPK1.18820998
34NEK61.15900621
35PAK21.14381063
36KSR11.13908706
37CSNK1A1L1.12640873
38ADRBK21.10854576
39WNK31.05571876
40BMPR21.05547415
41SGK21.04441783
42TAOK21.04361978
43FLT31.03957934
44INSRR0.98357204
45DYRK20.96720845
46PDGFRA0.94002701
47MINK10.93069723
48PKN10.88924478
49NUAK10.88252714
50TRIM280.86789595
51MAP3K140.83027935
52DYRK1B0.78694723
53TESK10.77071117
54MAP2K40.76027877
55DYRK1A0.76017573
56CAMK2A0.74851698
57FER0.74600966
58CDK30.74172438
59CDK50.73385961
60RIPK40.72676432
61STK38L0.72125870
62AKT30.70945346
63NTRK10.70226073
64PRKCE0.70208794
65DAPK20.69317175
66MAP4K20.68990394
67FGR0.68409432
68CLK10.68165333
69SGK4940.68142915
70SGK2230.68142915
71EPHB10.67442315
72IRAK20.66847860
73PRKCG0.65386219
74CAMK40.64558224
75MAP3K60.64105779
76TAOK30.63535562
77PAK30.61475568
78RPS6KA40.60854434
79CSNK1G20.60611618
80CSNK1G30.60309095
81SGK10.59099337
82TXK0.56148662
83MAPK40.56068984
84CAMKK10.55764199
85CAMK2B0.55739356
86CDK180.54309675
87ROCK10.53723482
88GRK70.52952404
89STK160.52684240
90CDK80.51546952
91ADRBK10.50319022
92TESK20.48610572
93ERBB20.47333893
94BMPR1B0.47056789
95BLK0.45138506
96RPS6KA20.44990238
97CDK150.44582816
98PAK60.44265160
99CDC42BPA0.44105057
100PRKG10.42417211
101BCKDK0.42084567
102CSNK1G10.40907671
103WNK10.40238849
104PRKACA0.39708817
105MUSK0.39131076
106GRK10.38581888
107CDK140.38382446
108PRKCB0.38327958
109SGK30.37648033
110MARK20.37539610
111WNK40.37142696
112PHKG20.36956788
113PHKG10.36956788
114MAPK150.36018853
115NEK20.34915994
116CSNK1A10.34746878
117MAP3K110.34028376
118STK30.33344262
119CDK11A0.31867579
120CAMK1D0.31210208
121CSNK1E0.31108111
122BRD40.30982663
123CDK190.30493870
124STK240.30092289
125PTK2B0.30030301
126PBK0.29412297
127GSK3B0.28740624
128CSNK1D0.27867959
129PDGFRB0.27242831
130LIMK10.27210729
131PRKCZ0.25588754
132PRKACB0.24919057
133RPS6KA30.24836034
134CCNB10.23292569
135PRKAA10.21070341
136PRKDC0.21021149
137TYRO30.20952653
138MAPK80.20867260
139MAPK90.20073943
140PRKCH0.19618546
141PRKACG0.19158513

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03245987
2Axon guidance_Homo sapiens_hsa043602.54392380
3Cardiac muscle contraction_Homo sapiens_hsa042602.35544169
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26299824
5Morphine addiction_Homo sapiens_hsa050322.16116713
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.07983903
7Oxidative phosphorylation_Homo sapiens_hsa001902.04322294
8Glutamatergic synapse_Homo sapiens_hsa047241.99763778
9Parkinsons disease_Homo sapiens_hsa050121.96805295
10Taste transduction_Homo sapiens_hsa047421.96144834
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93093438
12Synaptic vesicle cycle_Homo sapiens_hsa047211.90357238
13Circadian entrainment_Homo sapiens_hsa047131.84559358
14GABAergic synapse_Homo sapiens_hsa047271.83805672
15Serotonergic synapse_Homo sapiens_hsa047261.71486502
16Basal cell carcinoma_Homo sapiens_hsa052171.69605901
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68738800
18Olfactory transduction_Homo sapiens_hsa047401.62698479
19Phototransduction_Homo sapiens_hsa047441.59676576
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57314920
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53615763
22Hedgehog signaling pathway_Homo sapiens_hsa043401.50734984
23Wnt signaling pathway_Homo sapiens_hsa043101.41159633
24Alzheimers disease_Homo sapiens_hsa050101.40694187
25Sulfur relay system_Homo sapiens_hsa041221.35563622
26Calcium signaling pathway_Homo sapiens_hsa040201.34037613
27Huntingtons disease_Homo sapiens_hsa050161.33653994
28Dopaminergic synapse_Homo sapiens_hsa047281.29113175
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29011105
30Hippo signaling pathway_Homo sapiens_hsa043901.23121024
31Cholinergic synapse_Homo sapiens_hsa047251.22704731
32Amphetamine addiction_Homo sapiens_hsa050311.22114806
33Long-term potentiation_Homo sapiens_hsa047201.22006075
34Melanogenesis_Homo sapiens_hsa049161.16833064
35Long-term depression_Homo sapiens_hsa047301.15489678
36Collecting duct acid secretion_Homo sapiens_hsa049661.12471583
37Salivary secretion_Homo sapiens_hsa049701.11949081
38Phagosome_Homo sapiens_hsa041451.10580087
39Renin secretion_Homo sapiens_hsa049241.07625387
40Insulin secretion_Homo sapiens_hsa049111.07283500
41Autoimmune thyroid disease_Homo sapiens_hsa053201.06325343
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03945224
43Type I diabetes mellitus_Homo sapiens_hsa049401.03719164
44ErbB signaling pathway_Homo sapiens_hsa040121.03622118
45Cocaine addiction_Homo sapiens_hsa050301.01669483
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00925028
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00389414
48Gap junction_Homo sapiens_hsa045400.99903912
49Ovarian steroidogenesis_Homo sapiens_hsa049130.99575024
50Rheumatoid arthritis_Homo sapiens_hsa053230.99045051
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96715145
52Allograft rejection_Homo sapiens_hsa053300.95084414
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94729508
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89129148
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88335314
56Graft-versus-host disease_Homo sapiens_hsa053320.86460927
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84290391
58Colorectal cancer_Homo sapiens_hsa052100.83879137
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83796818
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83338378
61Prolactin signaling pathway_Homo sapiens_hsa049170.83272867
62Adherens junction_Homo sapiens_hsa045200.82864177
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82603382
64TGF-beta signaling pathway_Homo sapiens_hsa043500.81853605
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80195620
66Oxytocin signaling pathway_Homo sapiens_hsa049210.79866575
67cAMP signaling pathway_Homo sapiens_hsa040240.79844511
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78806752
69Melanoma_Homo sapiens_hsa052180.78498552
70Linoleic acid metabolism_Homo sapiens_hsa005910.77924603
71Vibrio cholerae infection_Homo sapiens_hsa051100.77535795
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75122318
73Ras signaling pathway_Homo sapiens_hsa040140.74296812
74GnRH signaling pathway_Homo sapiens_hsa049120.73889599
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73372581
76MAPK signaling pathway_Homo sapiens_hsa040100.72654209
77Butanoate metabolism_Homo sapiens_hsa006500.72567016
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72303618
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71718012
80African trypanosomiasis_Homo sapiens_hsa051430.71495505
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71476752
82Thyroid cancer_Homo sapiens_hsa052160.70156490
83Rap1 signaling pathway_Homo sapiens_hsa040150.69558331
84Type II diabetes mellitus_Homo sapiens_hsa049300.68424024
85Alcoholism_Homo sapiens_hsa050340.67041980
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.66866224
87Protein export_Homo sapiens_hsa030600.65482501
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65056378
89Fanconi anemia pathway_Homo sapiens_hsa034600.64002568
90Gastric acid secretion_Homo sapiens_hsa049710.62315535
91Dilated cardiomyopathy_Homo sapiens_hsa054140.61973445
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60969460
93Salmonella infection_Homo sapiens_hsa051320.60341287
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59520506
95Endometrial cancer_Homo sapiens_hsa052130.58706984
96Ether lipid metabolism_Homo sapiens_hsa005650.58600715
97MicroRNAs in cancer_Homo sapiens_hsa052060.57852092
98Chemokine signaling pathway_Homo sapiens_hsa040620.57127750
99Glioma_Homo sapiens_hsa052140.56388738
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55297699
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54925931
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54700826
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52999049
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52900660
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52475765
106Asthma_Homo sapiens_hsa053100.51422672
107Pathways in cancer_Homo sapiens_hsa052000.50442568
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49538200
109Viral myocarditis_Homo sapiens_hsa054160.49375532
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.48700473
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48552614
112Proteoglycans in cancer_Homo sapiens_hsa052050.47832590
113Prostate cancer_Homo sapiens_hsa052150.46869546
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46647296
115Circadian rhythm_Homo sapiens_hsa047100.46500696
116ECM-receptor interaction_Homo sapiens_hsa045120.44184549
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.43004342
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42822042
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.40893462
120TNF signaling pathway_Homo sapiens_hsa046680.40449555
121Peroxisome_Homo sapiens_hsa041460.38903326
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36658048
123Basal transcription factors_Homo sapiens_hsa030220.36201130
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35371362
125Dorso-ventral axis formation_Homo sapiens_hsa043200.34569746
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.33893444
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32482407
128Chemical carcinogenesis_Homo sapiens_hsa052040.32380466
129Starch and sucrose metabolism_Homo sapiens_hsa005000.30200712
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27411861
131AMPK signaling pathway_Homo sapiens_hsa041520.25899444
132Fructose and mannose metabolism_Homo sapiens_hsa000510.24892510
133Steroid biosynthesis_Homo sapiens_hsa001000.24734240
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.24404700

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