LIAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.79240144
2ATP synthesis coupled proton transport (GO:0015986)5.16665456
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.16665456
4proteasome assembly (GO:0043248)4.88903091
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.85202386
6respiratory electron transport chain (GO:0022904)4.49737165
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.49371591
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.49371591
9NADH dehydrogenase complex assembly (GO:0010257)4.49371591
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.42232298
11termination of RNA polymerase III transcription (GO:0006386)4.42232298
12protein complex biogenesis (GO:0070271)4.41589467
13electron transport chain (GO:0022900)4.40554422
14purine nucleobase biosynthetic process (GO:0009113)4.30336222
15guanosine-containing compound biosynthetic process (GO:1901070)4.22852391
16regulation of mitochondrial translation (GO:0070129)4.19351450
17cullin deneddylation (GO:0010388)4.18595952
18mitochondrial respiratory chain complex assembly (GO:0033108)4.18179968
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.11754661
207-methylguanosine mRNA capping (GO:0006370)4.07470191
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.06819520
22maturation of SSU-rRNA (GO:0030490)4.06578209
23nucleobase biosynthetic process (GO:0046112)4.05869543
24RNA capping (GO:0036260)4.04418625
257-methylguanosine RNA capping (GO:0009452)4.04418625
26respiratory chain complex IV assembly (GO:0008535)4.00180221
27maturation of 5.8S rRNA (GO:0000460)3.93373329
28protein deneddylation (GO:0000338)3.92811706
29DNA deamination (GO:0045006)3.92727020
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92417623
31GTP biosynthetic process (GO:0006183)3.89457156
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.86895771
33regulation of cellular amino acid metabolic process (GO:0006521)3.83087616
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81651475
35L-methionine salvage (GO:0071267)3.74648970
36L-methionine biosynthetic process (GO:0071265)3.74648970
37amino acid salvage (GO:0043102)3.74648970
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70092411
39rRNA modification (GO:0000154)3.69385671
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66224075
41negative regulation of ligase activity (GO:0051352)3.66224075
42chaperone-mediated protein transport (GO:0072321)3.57816107
43transcription elongation from RNA polymerase I promoter (GO:0006362)3.56881712
44spliceosomal snRNP assembly (GO:0000387)3.54101425
45cytochrome complex assembly (GO:0017004)3.53316688
46pseudouridine synthesis (GO:0001522)3.52239193
47termination of RNA polymerase I transcription (GO:0006363)3.51275146
48replication fork processing (GO:0031297)3.50468489
49NADH metabolic process (GO:0006734)3.50203177
50oxidative phosphorylation (GO:0006119)3.50052193
51UTP biosynthetic process (GO:0006228)3.50017914
52cellular ketone body metabolic process (GO:0046950)3.49379633
53GMP metabolic process (GO:0046037)3.47381279
54protein neddylation (GO:0045116)3.46800913
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46049127
56water-soluble vitamin biosynthetic process (GO:0042364)3.44761558
57nonmotile primary cilium assembly (GO:0035058)3.43969248
58establishment of protein localization to mitochondrion (GO:0072655)3.43014983
59transcription from RNA polymerase I promoter (GO:0006360)3.41530718
60cellular component biogenesis (GO:0044085)3.40857322
61DNA replication checkpoint (GO:0000076)3.40112038
62protein targeting to mitochondrion (GO:0006626)3.38762436
63protein K6-linked ubiquitination (GO:0085020)3.38706242
64translation (GO:0006412)3.36090294
65positive regulation of ligase activity (GO:0051351)3.35689882
66ribosome biogenesis (GO:0042254)3.34427369
67DNA double-strand break processing (GO:0000729)3.33767591
68ribosomal large subunit biogenesis (GO:0042273)3.33244915
69chromatin remodeling at centromere (GO:0031055)3.31069289
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29273758
71behavioral response to nicotine (GO:0035095)3.28667160
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27578986
73ribonucleoprotein complex biogenesis (GO:0022613)3.26309919
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25940832
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24874032
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24874032
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24874032
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23798713
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23798713
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.21142494
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21142494
82platelet dense granule organization (GO:0060155)3.19130489
83protein localization to mitochondrion (GO:0070585)3.18798789
84signal transduction involved in cell cycle checkpoint (GO:0072395)3.17583611
85ribosomal small subunit assembly (GO:0000028)3.17128888
86peptidyl-histidine modification (GO:0018202)3.16868952
87formation of translation preinitiation complex (GO:0001731)3.16132249
88resolution of meiotic recombination intermediates (GO:0000712)3.15946056
89* protein-cofactor linkage (GO:0018065)3.14998931
90CTP biosynthetic process (GO:0006241)3.13042478
91CTP metabolic process (GO:0046036)3.13042478
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12817189
93regulation of hexokinase activity (GO:1903299)3.12769735
94regulation of glucokinase activity (GO:0033131)3.12769735
95UTP metabolic process (GO:0046051)3.11702826
96transcription-coupled nucleotide-excision repair (GO:0006283)3.11682943
97ketone body metabolic process (GO:1902224)3.08893803
98CENP-A containing nucleosome assembly (GO:0034080)3.08733269
99rRNA processing (GO:0006364)3.07187065
100rRNA methylation (GO:0031167)3.06778674
101ubiquinone biosynthetic process (GO:0006744)3.06533292
102quinone biosynthetic process (GO:1901663)3.06533292
103transcription initiation from RNA polymerase I promoter (GO:0006361)3.05924586
104centriole replication (GO:0007099)3.04709468
105spliceosomal complex assembly (GO:0000245)3.04588013
106piRNA metabolic process (GO:0034587)3.03304625
107synapsis (GO:0007129)3.03098954
108cotranslational protein targeting to membrane (GO:0006613)3.02593480
109metallo-sulfur cluster assembly (GO:0031163)3.01457177
110iron-sulfur cluster assembly (GO:0016226)3.01457177
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01408782
112RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01408782
113purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01270816
114DNA damage response, detection of DNA damage (GO:0042769)3.01098350
115regulation of ubiquitin-protein transferase activity (GO:0051438)3.01067466
116deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00997760
117negative regulation of DNA-dependent DNA replication (GO:2000104)3.00724317
118somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00502045
119somatic hypermutation of immunoglobulin genes (GO:0016446)3.00502045
120recombinational repair (GO:0000725)3.00150871
121ribosomal small subunit biogenesis (GO:0042274)2.99802806
122pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.99474673
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99290389
124purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98768508
125double-strand break repair via homologous recombination (GO:0000724)2.94953159
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.92337271
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91620559
128response to pheromone (GO:0019236)2.91478587
129intracellular protein transmembrane import (GO:0044743)2.87534505
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87452913
131mannosylation (GO:0097502)2.77882844
132reciprocal DNA recombination (GO:0035825)2.77398725
133reciprocal meiotic recombination (GO:0007131)2.77398725
134meiotic chromosome segregation (GO:0045132)2.75566969
135tRNA processing (GO:0008033)2.75316805
136histone exchange (GO:0043486)2.73632861
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72318380
138mitochondrial RNA metabolic process (GO:0000959)2.71694907
139regulation of cilium movement (GO:0003352)2.71037455
140DNA catabolic process, exonucleolytic (GO:0000738)2.65557716
141negative regulation of telomere maintenance (GO:0032205)2.64710648
142regulation of meiosis I (GO:0060631)2.63873904
143male meiosis I (GO:0007141)2.62377771
144organelle disassembly (GO:1903008)2.62354436
145cornea development in camera-type eye (GO:0061303)2.60298759
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58648498
147ubiquinone metabolic process (GO:0006743)2.56945505
148epithelial cilium movement (GO:0003351)2.53886373
149neural tube formation (GO:0001841)2.52075863
150rRNA catabolic process (GO:0016075)2.49823141
151postreplication repair (GO:0006301)2.47497726
152axoneme assembly (GO:0035082)2.47125170
153fucose catabolic process (GO:0019317)2.46421321
154L-fucose metabolic process (GO:0042354)2.46421321
155L-fucose catabolic process (GO:0042355)2.46421321
156inner mitochondrial membrane organization (GO:0007007)2.45285594
157somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.44924517
158isotype switching (GO:0045190)2.44924517
159somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.44924517
160photoreceptor cell maintenance (GO:0045494)2.44764828
161detection of light stimulus involved in sensory perception (GO:0050962)2.44684060
162detection of light stimulus involved in visual perception (GO:0050908)2.44684060
163translational termination (GO:0006415)2.42830280
164hydrogen ion transmembrane transport (GO:1902600)2.42271852
165regulation of mitotic spindle checkpoint (GO:1903504)2.41603132
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.41603132
167cilium morphogenesis (GO:0060271)2.38416557
168tRNA metabolic process (GO:0006399)2.37701280
169ATP biosynthetic process (GO:0006754)2.37266702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.12861770
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.39379575
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.35240318
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.16907491
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.93630073
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.86181562
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.82750612
8ZNF274_21170338_ChIP-Seq_K562_Hela3.73121843
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.66771007
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.35197949
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.20436928
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10817626
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07926804
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.00796898
15E2F7_22180533_ChIP-Seq_HELA_Human2.97526119
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91665768
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87849211
18* VDR_23849224_ChIP-Seq_CD4+_Human2.72072952
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69030308
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65211361
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.63847531
22DCP1A_22483619_ChIP-Seq_HELA_Human2.57530305
23* SRF_21415370_ChIP-Seq_HL-1_Mouse2.52797830
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52381301
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50629322
26EWS_26573619_Chip-Seq_HEK293_Human2.39255108
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38728361
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37190193
29IGF1R_20145208_ChIP-Seq_DFB_Human2.35109395
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.28996953
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24171716
32FOXP3_21729870_ChIP-Seq_TREG_Human2.22531411
33EZH2_22144423_ChIP-Seq_EOC_Human2.16787445
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.15915045
35* XRN2_22483619_ChIP-Seq_HELA_Human2.13567317
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09809649
37E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09788836
38GABP_19822575_ChIP-Seq_HepG2_Human2.09572472
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06914106
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05445219
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04423353
42TAF15_26573619_Chip-Seq_HEK293_Human2.03395451
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02848268
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97858192
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96501043
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94055553
47ELK1_19687146_ChIP-ChIP_HELA_Human1.93699193
48* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90055238
49* TTF2_22483619_ChIP-Seq_HELA_Human1.87573681
50GBX2_23144817_ChIP-Seq_PC3_Human1.85117814
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80799891
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74869058
53P300_19829295_ChIP-Seq_ESCs_Human1.70943954
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70148643
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70086989
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69783285
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66644118
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63073969
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59901998
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59468841
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56108926
62ER_23166858_ChIP-Seq_MCF-7_Human1.54865876
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53962077
64* TP53_22573176_ChIP-Seq_HFKS_Human1.51499151
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51211534
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47170395
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44488910
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41227592
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40905056
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37587128
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36386752
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36359426
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35559062
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33526433
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29627215
76CBP_20019798_ChIP-Seq_JUKART_Human1.29627215
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27646753
78KDM5A_27292631_Chip-Seq_BREAST_Human1.23577451
79SOX2_19829295_ChIP-Seq_ESCs_Human1.23263287
80NANOG_19829295_ChIP-Seq_ESCs_Human1.23263287
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22602146
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.22291102
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21442649
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20499874
85BCAT_22108803_ChIP-Seq_LS180_Human1.19938519
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19824758
87AR_21909140_ChIP-Seq_LNCAP_Human1.19703637
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19312640
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.18565958
90MYC_18940864_ChIP-ChIP_HL60_Human1.18317641
91* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17513134
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17484044
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.17484044
94CIITA_25753668_ChIP-Seq_RAJI_Human1.17233146
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13257085
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10176402
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09519960
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07989563
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.07210939
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06009209
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05927553
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04529367
103AR_20517297_ChIP-Seq_VCAP_Human1.04400591
104* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04178453
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03685511
106* STAT3_23295773_ChIP-Seq_U87_Human1.03591864
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02961155
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.02870730
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.02144428
110TCF4_23295773_ChIP-Seq_U87_Human1.01503910
111AR_25329375_ChIP-Seq_VCAP_Human1.01399860
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01281408
113FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99318480
114NCOR_22424771_ChIP-Seq_293T_Human0.98685061
115SMAD4_21799915_ChIP-Seq_A2780_Human0.98600492
116TCF4_22108803_ChIP-Seq_LS180_Human0.97803733
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97417763
118E2F1_21310950_ChIP-Seq_MCF-7_Human0.96630420
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96162891
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95744900
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95188906
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94962485
123RNF2_27304074_Chip-Seq_NSC_Mouse0.94660942
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93486057
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.93210146
126GATA3_21878914_ChIP-Seq_MCF-7_Human0.92844597
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92638467
128IRF1_19129219_ChIP-ChIP_H3396_Human0.92433619
129HOXB7_26014856_ChIP-Seq_BT474_Human0.92323258
130RUNX2_22187159_ChIP-Seq_PCA_Human0.92142144
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.91564646
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91541414
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91148644
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90047942
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.89954575
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89809055
137P53_22387025_ChIP-Seq_ESCs_Mouse0.89150752
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88980806
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88758238
140* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88756888
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87536439
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86675012
143* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86512868
144VDR_22108803_ChIP-Seq_LS180_Human0.86383378
145HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86329855
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85388715
147KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81304566
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80313397
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.77685241
150FOXM1_23109430_ChIP-Seq_U2OS_Human0.76864231
151* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75991905
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75978240
153CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75544503
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74488511
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72688798
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.71987420
157NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66794699
158FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.66158136
159PCGF2_27294783_Chip-Seq_ESCs_Mouse0.64976963
160FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64619507
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.64472881
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64261269
163KLF4_18555785_ChIP-Seq_MESCs_Mouse0.63229510
164FUS_26573619_Chip-Seq_HEK293_Human0.63185249
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.62981280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.37769108
2MP0006036_abnormal_mitochondrial_physio3.34016254
3MP0003806_abnormal_nucleotide_metabolis3.21553225
4MP0004957_abnormal_blastocyst_morpholog3.07080515
5MP0008058_abnormal_DNA_repair2.94305149
6MP0002837_dystrophic_cardiac_calcinosis2.93878141
7MP0009379_abnormal_foot_pigmentation2.70343690
8MP0004147_increased_porphyrin_level2.65802364
9MP0010094_abnormal_chromosome_stability2.61434961
10MP0001529_abnormal_vocalization2.57655935
11MP0009697_abnormal_copulation2.55433068
12MP0003111_abnormal_nucleus_morphology2.49358779
13MP0003718_maternal_effect2.42281011
14MP0006035_abnormal_mitochondrial_morpho2.26634469
15MP0003787_abnormal_imprinting2.26622984
16MP0002102_abnormal_ear_morphology2.26156718
17MP0008057_abnormal_DNA_replication2.19402858
18MP0005551_abnormal_eye_electrophysiolog2.15760281
19MP0003077_abnormal_cell_cycle1.96984961
20MP0002163_abnormal_gland_morphology1.95630180
21MP0002139_abnormal_hepatobiliary_system1.88546186
22MP0001986_abnormal_taste_sensitivity1.86954962
23MP0003123_paternal_imprinting1.85259172
24MP0003195_calcinosis1.81954003
25MP0000372_irregular_coat_pigmentation1.80539147
26MP0000569_abnormal_digit_pigmentation1.80392335
27* MP0001764_abnormal_homeostasis1.79031363
28MP0003186_abnormal_redox_activity1.76445461
29MP0001905_abnormal_dopamine_level1.72994935
30MP0008932_abnormal_embryonic_tissue1.68691369
31MP0005253_abnormal_eye_physiology1.65511172
32MP0006276_abnormal_autonomic_nervous1.64929400
33MP0003121_genomic_imprinting1.63385797
34MP0008789_abnormal_olfactory_epithelium1.61667950
35MP0001188_hyperpigmentation1.61355151
36MP0003646_muscle_fatigue1.57906385
37MP0000631_abnormal_neuroendocrine_gland1.57771279
38MP0004215_abnormal_myocardial_fiber1.57189621
39MP0002277_abnormal_respiratory_mucosa1.56878134
40MP0005646_abnormal_pituitary_gland1.55532747
41MP0005379_endocrine/exocrine_gland_phen1.54615187
42MP0002876_abnormal_thyroid_physiology1.53770802
43MP0004133_heterotaxia1.50774457
44MP0008872_abnormal_physiological_respon1.50733531
45MP0008995_early_reproductive_senescence1.49599714
46MP0004885_abnormal_endolymph1.46350020
47MP0003786_premature_aging1.43705810
48MP0002928_abnormal_bile_duct1.43552255
49MP0002638_abnormal_pupillary_reflex1.41156976
50MP0008877_abnormal_DNA_methylation1.40533543
51MP0004084_abnormal_cardiac_muscle1.40375587
52MP0008875_abnormal_xenobiotic_pharmacok1.32786483
53MP0001293_anophthalmia1.29984694
54MP0003656_abnormal_erythrocyte_physiolo1.29257821
55MP0005330_cardiomyopathy1.28900700
56MP0001984_abnormal_olfaction1.28382868
57MP0001968_abnormal_touch/_nociception1.28156092
58MP0005174_abnormal_tail_pigmentation1.27761649
59MP0005645_abnormal_hypothalamus_physiol1.27696593
60MP0005085_abnormal_gallbladder_physiolo1.27222008
61MP0002160_abnormal_reproductive_system1.27033929
62MP0009046_muscle_twitch1.24029237
63MP0000749_muscle_degeneration1.23188578
64MP0002653_abnormal_ependyma_morphology1.22801708
65MP0000427_abnormal_hair_cycle1.22705171
66MP0005332_abnormal_amino_acid1.21926526
67MP0006292_abnormal_olfactory_placode1.21912446
68MP0008260_abnormal_autophagy1.21243782
69MP0001661_extended_life_span1.20718313
70MP0004145_abnormal_muscle_electrophysio1.20005730
71MP0005451_abnormal_body_composition1.19049077
72MP0004043_abnormal_pH_regulation1.18416590
73MP0005266_abnormal_metabolism1.17337958
74MP0004036_abnormal_muscle_relaxation1.15534166
75MP0002234_abnormal_pharynx_morphology1.15514292
76MP0004742_abnormal_vestibular_system1.14707224
77MP0005075_abnormal_melanosome_morpholog1.14237590
78MP0003221_abnormal_cardiomyocyte_apopto1.14060083
79MP0004142_abnormal_muscle_tone1.12462197
80MP0010386_abnormal_urinary_bladder1.11538378
81MP0002736_abnormal_nociception_after1.11007010
82MP0005365_abnormal_bile_salt1.08256110
83MP0005499_abnormal_olfactory_system1.07335552
84MP0005394_taste/olfaction_phenotype1.07335552
85MP0009745_abnormal_behavioral_response1.07289574
86MP0005389_reproductive_system_phenotype1.06815395
87MP0001929_abnormal_gametogenesis1.06788175
88MP0002210_abnormal_sex_determination1.06641995
89MP0005636_abnormal_mineral_homeostasis1.06238719
90MP0001542_abnormal_bone_strength1.05200322
91MP0002095_abnormal_skin_pigmentation1.04560257
92MP0000013_abnormal_adipose_tissue1.02310792
93MP0000647_abnormal_sebaceous_gland1.02294269
94MP0001486_abnormal_startle_reflex1.00971186
95MP0008007_abnormal_cellular_replicative1.00852521
96MP0003890_abnormal_embryonic-extraembry0.99327628
97MP0000358_abnormal_cell_content/0.98435495
98MP0006072_abnormal_retinal_apoptosis0.97088230
99MP0005195_abnormal_posterior_eye0.96252281
100MP0005410_abnormal_fertilization0.95986186
101MP0003879_abnormal_hair_cell0.94820365
102MP0003880_abnormal_central_pattern0.93539749
103MP0002138_abnormal_hepatobiliary_system0.92842366
104MP0001145_abnormal_male_reproductive0.91220471
105MP0003698_abnormal_male_reproductive0.90383677
106MP0000747_muscle_weakness0.87831238
107* MP0001730_embryonic_growth_arrest0.87791196
108MP0002735_abnormal_chemical_nociception0.86421578
109MP0002557_abnormal_social/conspecific_i0.85685035
110MP0002938_white_spotting0.85051927
111MP0001485_abnormal_pinna_reflex0.84729378
112MP0002332_abnormal_exercise_endurance0.84635336
113MP0005220_abnormal_exocrine_pancreas0.83671827
114MP0001119_abnormal_female_reproductive0.82864353
115MP0003136_yellow_coat_color0.80864863
116MP0005084_abnormal_gallbladder_morpholo0.80280643
117MP0000026_abnormal_inner_ear0.79961869
118MP0000778_abnormal_nervous_system0.79478686
119MP0003137_abnormal_impulse_conducting0.79374430
120MP0001324_abnormal_eye_pigmentation0.78638752
121MP0000653_abnormal_sex_gland0.78483579
122MP0005319_abnormal_enzyme/_coenzyme0.78249674
123MP0002272_abnormal_nervous_system0.78140471
124MP0005391_vision/eye_phenotype0.78064078
125MP0005423_abnormal_somatic_nervous0.77285382
126MP0002752_abnormal_somatic_nervous0.76734060
127MP0003315_abnormal_perineum_morphology0.76628469
128MP0008775_abnormal_heart_ventricle0.76556468
129MP0001919_abnormal_reproductive_system0.75454846
130* MP0005376_homeostasis/metabolism_phenot0.75207783
131MP0001501_abnormal_sleep_pattern0.74796982
132MP0003937_abnormal_limbs/digits/tail_de0.74598796
133MP0005535_abnormal_body_temperature0.74560039
134MP0002269_muscular_atrophy0.74192206
135MP0009333_abnormal_splenocyte_physiolog0.68378726
136MP0005409_darkened_coat_color0.68378413
137MP0005360_urolithiasis0.67620444
138MP0002078_abnormal_glucose_homeostasis0.67597249
139MP0003122_maternal_imprinting0.67359903
140MP0002693_abnormal_pancreas_physiology0.66532389
141MP0002734_abnormal_mechanical_nocicepti0.65870395
142MP0002127_abnormal_cardiovascular_syste0.64111536
143MP0005670_abnormal_white_adipose0.63925898
144MP0003567_abnormal_fetal_cardiomyocyte0.63912949
145MP0001440_abnormal_grooming_behavior0.63087664
146MP0003011_delayed_dark_adaptation0.62176763
147MP0004019_abnormal_vitamin_homeostasis0.60521771
148MP0000015_abnormal_ear_pigmentation0.59183018

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.45835751
2Hepatocellular necrosis (HP:0001404)5.07693335
3Abnormal mitochondria in muscle tissue (HP:0008316)5.04620681
4Mitochondrial inheritance (HP:0001427)4.99834699
5Hepatic necrosis (HP:0002605)4.91365585
6Acute encephalopathy (HP:0006846)4.77554152
7Increased CSF lactate (HP:0002490)4.77393437
8Abnormality of glycolysis (HP:0004366)4.57661384
9Increased serum pyruvate (HP:0003542)4.57661384
10Progressive macrocephaly (HP:0004481)4.46215342
11Cerebral edema (HP:0002181)3.79906465
12* Increased serum lactate (HP:0002151)3.70637429
13Molar tooth sign on MRI (HP:0002419)3.61644028
14Abnormality of midbrain morphology (HP:0002418)3.61644028
15Increased hepatocellular lipid droplets (HP:0006565)3.58448284
16* Lactic acidosis (HP:0003128)3.49057497
17Lipid accumulation in hepatocytes (HP:0006561)3.48631752
183-Methylglutaconic aciduria (HP:0003535)3.42622060
19Hyperglycinemia (HP:0002154)3.38556404
20Respiratory failure (HP:0002878)3.25227587
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22936976
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22936976
23Exercise intolerance (HP:0003546)3.19056232
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17298907
25Abnormality of alanine metabolism (HP:0010916)3.17298907
26Hyperalaninemia (HP:0003348)3.17298907
27Nephronophthisis (HP:0000090)3.13923022
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09299698
29Microvesicular hepatic steatosis (HP:0001414)3.05139564
30Birth length less than 3rd percentile (HP:0003561)3.03253129
31CNS demyelination (HP:0007305)2.96931750
32Renal Fanconi syndrome (HP:0001994)2.94909580
33Cerebral hypomyelination (HP:0006808)2.94876795
34Increased intramyocellular lipid droplets (HP:0012240)2.91103349
35Hyperglycinuria (HP:0003108)2.89630375
36Lethargy (HP:0001254)2.88457403
37Abnormality of the labia minora (HP:0012880)2.79647944
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.79201257
39Increased muscle lipid content (HP:0009058)2.77033663
40Abnormality of serum amino acid levels (HP:0003112)2.75295184
41Optic disc pallor (HP:0000543)2.73293744
42Congenital stationary night blindness (HP:0007642)2.72972385
43Type II lissencephaly (HP:0007260)2.71306524
44Abnormality of the renal cortex (HP:0011035)2.70744069
45Abnormality of the renal medulla (HP:0100957)2.70739442
46Abnormality of glycine metabolism (HP:0010895)2.68623340
47Abnormality of serine family amino acid metabolism (HP:0010894)2.68623340
48Leukodystrophy (HP:0002415)2.59546148
49Methylmalonic aciduria (HP:0012120)2.56574935
50Dicarboxylic aciduria (HP:0003215)2.56493229
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56493229
52Emotional lability (HP:0000712)2.52572935
53Pendular nystagmus (HP:0012043)2.52372507
54Macrocytic anemia (HP:0001972)2.49879080
55Pancreatic fibrosis (HP:0100732)2.49458394
56Respiratory difficulties (HP:0002880)2.47700358
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.41624545
58Abnormality of cells of the erythroid lineage (HP:0012130)2.38237288
59Type I transferrin isoform profile (HP:0003642)2.36929510
60Neuroendocrine neoplasm (HP:0100634)2.34135811
61Nephrogenic diabetes insipidus (HP:0009806)2.33817060
62Cystic liver disease (HP:0006706)2.31683417
63Abnormal number of erythroid precursors (HP:0012131)2.30459222
64Abnormal rod and cone electroretinograms (HP:0008323)2.28283509
65Sclerocornea (HP:0000647)2.27166187
66Pancreatic cysts (HP:0001737)2.26377035
67Attenuation of retinal blood vessels (HP:0007843)2.25657863
68Genital tract atresia (HP:0001827)2.23771425
69Chronic hepatic failure (HP:0100626)2.23710627
70Megaloblastic anemia (HP:0001889)2.21196865
71Oral leukoplakia (HP:0002745)2.17888904
72Breast hypoplasia (HP:0003187)2.17580281
73Septo-optic dysplasia (HP:0100842)2.15644784
74Abnormal pupillary function (HP:0007686)2.15439196
75Optic nerve hypoplasia (HP:0000609)2.13146122
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.11842788
77Glycosuria (HP:0003076)2.11574626
78Abnormality of urine glucose concentration (HP:0011016)2.11574626
79Exertional dyspnea (HP:0002875)2.10449624
80Degeneration of anterior horn cells (HP:0002398)2.07998886
81Abnormality of the anterior horn cell (HP:0006802)2.07998886
82Pheochromocytoma (HP:0002666)2.06828821
83Methylmalonic acidemia (HP:0002912)2.05948304
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05424119
85Abolished electroretinogram (ERG) (HP:0000550)2.04977378
86Abnormality of renal resorption (HP:0011038)2.04775813
87Chromsome breakage (HP:0040012)2.03991896
88Vaginal atresia (HP:0000148)2.03984519
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03505633
90Colon cancer (HP:0003003)2.02973352
91Rough bone trabeculation (HP:0100670)2.02503906
92Unsteady gait (HP:0002317)2.00854838
93Gliosis (HP:0002171)2.00793973
94Furrowed tongue (HP:0000221)2.00092033
95Hypothermia (HP:0002045)1.99942421
96Postaxial foot polydactyly (HP:0001830)1.99838833
97Medial flaring of the eyebrow (HP:0010747)1.99246467
98Abnormal drinking behavior (HP:0030082)1.99187163
99Polydipsia (HP:0001959)1.99187163
100Meckel diverticulum (HP:0002245)1.99144695
101CNS hypomyelination (HP:0003429)1.98951178
102Palpitations (HP:0001962)1.95431430
103Abnormality of chromosome stability (HP:0003220)1.94238840
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.94175813
105Abnormality of the ileum (HP:0001549)1.94130068
106Anencephaly (HP:0002323)1.93747555
107Secondary amenorrhea (HP:0000869)1.93249468
108Cerebellar dysplasia (HP:0007033)1.92411032
109Aplastic anemia (HP:0001915)1.92104794
110Congenital, generalized hypertrichosis (HP:0004540)1.90182092
111Proximal tubulopathy (HP:0000114)1.89777907
112Abnormal biliary tract physiology (HP:0012439)1.89441562
113Bile duct proliferation (HP:0001408)1.89441562
114Sloping forehead (HP:0000340)1.89314687
115Male pseudohermaphroditism (HP:0000037)1.87644565
116Aplasia/hypoplasia of the uterus (HP:0008684)1.86990409
117Tubular atrophy (HP:0000092)1.86032956
118Abnormal protein glycosylation (HP:0012346)1.85864886
119Abnormal glycosylation (HP:0012345)1.85864886
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85864886
121Abnormal protein N-linked glycosylation (HP:0012347)1.85864886
122Progressive external ophthalmoplegia (HP:0000590)1.84842829
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83450237
124Congenital hepatic fibrosis (HP:0002612)1.83133545
125Short tibia (HP:0005736)1.82441233
126Delusions (HP:0000746)1.81935011
127Volvulus (HP:0002580)1.81262946
128Abnormal respiratory epithelium morphology (HP:0012253)1.80890562
129Abnormal respiratory motile cilium morphology (HP:0005938)1.80890562
130Congenital primary aphakia (HP:0007707)1.79767115
131True hermaphroditism (HP:0010459)1.79167079
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79166708
133Hyperphosphaturia (HP:0003109)1.78106650
134Reduced antithrombin III activity (HP:0001976)1.77994145
135Abnormality of vitamin B metabolism (HP:0004340)1.77839754
136Poor coordination (HP:0002370)1.77178038
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.76981041
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.76773202
139Abnormality of fatty-acid metabolism (HP:0004359)1.76689945
140Prolonged neonatal jaundice (HP:0006579)1.76055632
141Renal cortical cysts (HP:0000803)1.75719873
142Reticulocytopenia (HP:0001896)1.73362484
143Gait imbalance (HP:0002141)1.73150847
144Retinal dysplasia (HP:0007973)1.72218339
145Nausea (HP:0002018)1.71999517
146Progressive muscle weakness (HP:0003323)1.71690608
147Pancytopenia (HP:0001876)1.71334116
148Vomiting (HP:0002013)1.71152195
149Oculomotor apraxia (HP:0000657)1.69716403
150Abnormality of the pons (HP:0007361)1.69635769
151Hypoplasia of the pons (HP:0012110)1.69525320
152Small hand (HP:0200055)1.67916943
153Postaxial hand polydactyly (HP:0001162)1.67373437
154Chorioretinal atrophy (HP:0000533)1.66530126
155Inability to walk (HP:0002540)1.65520124
156Absent thumb (HP:0009777)1.65178489
157Stenosis of the external auditory canal (HP:0000402)1.64122696
158Decreased central vision (HP:0007663)1.63956082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.22221967
2STK163.90277424
3WEE13.79329442
4FRK3.37886710
5EIF2AK13.20766693
6NME22.86467519
7BCKDK2.60179476
8NME12.53155569
9PNCK2.38969207
10BRSK22.33936367
11PDK32.28571055
12PDK42.28571055
13SRPK12.27363773
14NUAK12.23726766
15TLK12.20802355
16AKT32.19690726
17TSSK62.16906838
18MAP4K22.09935909
19EIF2AK32.04197676
20ARAF1.95284825
21VRK11.91857796
22INSRR1.85245367
23PLK41.79974375
24TAOK31.78615273
25CCNB11.75971940
26BRAF1.66934505
27VRK21.65858041
28STK391.63488305
29MAP3K121.63174864
30PLK31.61664953
31CASK1.60656806
32BRSK11.60357562
33ACVR1B1.56276332
34CDC71.47025493
35TRIM281.43841304
36DYRK31.37570300
37PLK11.29004889
38MKNK21.20827724
39MYLK1.15573560
40OBSCN1.10177100
41AURKA1.10071754
42NEK11.09408491
43PDK21.09017132
44ZAK1.07750906
45PHKG11.04429821
46PHKG21.04429821
47PIM21.04350281
48STK38L1.03834336
49CDK31.02432094
50WNK30.98193587
51MAP2K70.95310933
52PINK10.95162401
53DYRK20.93654724
54NEK20.93019281
55TGFBR10.91801582
56TTK0.91196322
57BMPR1B0.90895448
58IRAK30.88092800
59MKNK10.87548902
60AURKB0.83019365
61CSNK2A10.81405687
62NTRK30.80608453
63CSNK2A20.77740157
64GRK70.76290811
65PASK0.75571970
66TAF10.75278415
67ERBB30.75247827
68CSNK1G30.74392522
69CDK80.73708095
70EIF2AK20.72498160
71RPS6KA50.72158626
72TXK0.70212663
73MUSK0.67250690
74PBK0.65941923
75MAPK150.65323359
76NLK0.64689097
77PIK3CG0.61897482
78CSNK1G10.59972164
79CHEK20.59892991
80PAK30.59709425
81STK240.59540027
82CAMK2G0.58995309
83BMPR20.58431009
84PRKCG0.58116581
85CAMK2D0.55287384
86OXSR10.54128292
87ADRBK10.54032352
88PIK3CA0.54029877
89STK30.53326540
90CAMKK20.52904870
91MAPK130.52515995
92PKN10.52416634
93MARK10.52390817
94CDK190.52275168
95MAPKAPK50.51866284
96ATR0.51722830
97EPHA20.50887841
98CAMK2B0.49934004
99EPHA40.49479129
100RPS6KA40.48855564
101TIE10.48702183
102PRKCQ0.48632326
103WNK40.47555446
104CDK70.47549258
105BCR0.47354541
106PRKCI0.47049848
107FGFR20.42855806
108CSNK1E0.42653323
109MST40.41772079
110MAP3K110.40589220
111GRK50.40353490
112MAP3K40.39915119
113TEC0.39820516
114CAMK2A0.39013233
115TNIK0.38003353
116CSNK1G20.37812160
117PRKG10.36699200
118DYRK1A0.36393491
119CHEK10.34433232
120PLK20.32831807
121PRKACB0.32328523
122IRAK10.32294936
123MINK10.32027084
124CAMK10.31811829
125ADRBK20.30807592
126MAP3K50.30752632
127CSNK1A10.30517930
128GRK10.30249151
129PRKCE0.27397936
130RPS6KB10.27048240
131CDK20.26671057
132NEK90.26557362
133ATM0.26480372
134PRKACA0.26189031

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.12376476
2Oxidative phosphorylation_Homo sapiens_hsa001903.69892484
3RNA polymerase_Homo sapiens_hsa030203.52289530
4Parkinsons disease_Homo sapiens_hsa050123.29331459
5Ribosome_Homo sapiens_hsa030103.23851268
6Protein export_Homo sapiens_hsa030602.86964917
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57518476
8Huntingtons disease_Homo sapiens_hsa050162.49123791
9Vitamin B6 metabolism_Homo sapiens_hsa007502.48118501
10Mismatch repair_Homo sapiens_hsa034302.22838490
11DNA replication_Homo sapiens_hsa030302.22026400
12Pyrimidine metabolism_Homo sapiens_hsa002402.21782925
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21018570
14Alzheimers disease_Homo sapiens_hsa050102.20803849
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86438141
16Spliceosome_Homo sapiens_hsa030401.81618289
17Nucleotide excision repair_Homo sapiens_hsa034201.77743809
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77190448
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74202073
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73053238
21RNA transport_Homo sapiens_hsa030131.71966084
22Homologous recombination_Homo sapiens_hsa034401.71786883
23Basal transcription factors_Homo sapiens_hsa030221.62418769
24Propanoate metabolism_Homo sapiens_hsa006401.50080556
25Folate biosynthesis_Homo sapiens_hsa007901.48756837
26Purine metabolism_Homo sapiens_hsa002301.48700461
27Base excision repair_Homo sapiens_hsa034101.48402011
28Nitrogen metabolism_Homo sapiens_hsa009101.45677666
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43629056
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40456418
31Fatty acid elongation_Homo sapiens_hsa000621.37504178
32Pyruvate metabolism_Homo sapiens_hsa006201.36045218
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33708202
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.29632830
35Cardiac muscle contraction_Homo sapiens_hsa042601.26329743
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18943439
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18932518
38Carbon metabolism_Homo sapiens_hsa012001.18846718
39Regulation of autophagy_Homo sapiens_hsa041401.18375154
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.11220539
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10836840
42Non-homologous end-joining_Homo sapiens_hsa034501.10248759
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08386383
44RNA degradation_Homo sapiens_hsa030181.07232990
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06378135
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06264770
47One carbon pool by folate_Homo sapiens_hsa006701.05039052
48Fanconi anemia pathway_Homo sapiens_hsa034601.04240638
49Ether lipid metabolism_Homo sapiens_hsa005651.03638351
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01998749
51Pentose phosphate pathway_Homo sapiens_hsa000301.01161002
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.99871481
53Cell cycle_Homo sapiens_hsa041100.98838727
54Sulfur relay system_Homo sapiens_hsa041220.98750703
55* Metabolic pathways_Homo sapiens_hsa011000.97076096
56Nicotine addiction_Homo sapiens_hsa050330.93908987
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92834356
58Biosynthesis of amino acids_Homo sapiens_hsa012300.91385746
59Butanoate metabolism_Homo sapiens_hsa006500.88159906
60Olfactory transduction_Homo sapiens_hsa047400.85623455
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83603885
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83498891
63Fatty acid degradation_Homo sapiens_hsa000710.82675644
64Collecting duct acid secretion_Homo sapiens_hsa049660.82051290
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79757148
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79314370
67Sulfur metabolism_Homo sapiens_hsa009200.78990291
68Peroxisome_Homo sapiens_hsa041460.77653219
69Taste transduction_Homo sapiens_hsa047420.77077591
70Phenylalanine metabolism_Homo sapiens_hsa003600.74569562
71Retinol metabolism_Homo sapiens_hsa008300.74179893
72Glutathione metabolism_Homo sapiens_hsa004800.73086007
73Tyrosine metabolism_Homo sapiens_hsa003500.70048064
74Arginine and proline metabolism_Homo sapiens_hsa003300.69614835
75Selenocompound metabolism_Homo sapiens_hsa004500.66693431
76Fatty acid metabolism_Homo sapiens_hsa012120.65039577
77beta-Alanine metabolism_Homo sapiens_hsa004100.64831802
78Vibrio cholerae infection_Homo sapiens_hsa051100.64007269
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.63476393
80Fructose and mannose metabolism_Homo sapiens_hsa000510.61487703
81Histidine metabolism_Homo sapiens_hsa003400.59578249
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58623678
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58081860
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.57834924
85Steroid biosynthesis_Homo sapiens_hsa001000.56833046
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56090923
87Caffeine metabolism_Homo sapiens_hsa002320.53168656
88Arachidonic acid metabolism_Homo sapiens_hsa005900.52038721
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51947491
90Tryptophan metabolism_Homo sapiens_hsa003800.49825479
91mRNA surveillance pathway_Homo sapiens_hsa030150.49624681
92Oocyte meiosis_Homo sapiens_hsa041140.46223417
93Circadian rhythm_Homo sapiens_hsa047100.46160663
94Linoleic acid metabolism_Homo sapiens_hsa005910.45750728
95Epstein-Barr virus infection_Homo sapiens_hsa051690.45344216
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45238346
97Morphine addiction_Homo sapiens_hsa050320.44166700
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43662884
99Primary immunodeficiency_Homo sapiens_hsa053400.40830830
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39848217
101Serotonergic synapse_Homo sapiens_hsa047260.36622836
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35707852
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35349517
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34861661
105Galactose metabolism_Homo sapiens_hsa000520.29576558
106Phototransduction_Homo sapiens_hsa047440.29561008
107Hedgehog signaling pathway_Homo sapiens_hsa043400.28029299
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27948673
109Insulin secretion_Homo sapiens_hsa049110.27935986
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27690560
111Circadian entrainment_Homo sapiens_hsa047130.27493763
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27478816
113Chemical carcinogenesis_Homo sapiens_hsa052040.25651667
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.25410242
115Vitamin digestion and absorption_Homo sapiens_hsa049770.23139204
116Sphingolipid metabolism_Homo sapiens_hsa006000.23081700
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22776406
118GABAergic synapse_Homo sapiens_hsa047270.21546120
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20669888
120Fat digestion and absorption_Homo sapiens_hsa049750.20358785
121p53 signaling pathway_Homo sapiens_hsa041150.17791255
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.16030678

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