Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.79240144 |
2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.16665456 |
3 | ATP synthesis coupled proton transport (GO:0015986) | 5.16665456 |
4 | proteasome assembly (GO:0043248) | 4.88903091 |
5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.85202386 |
6 | respiratory electron transport chain (GO:0022904) | 4.49737165 |
7 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.49371591 |
8 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.49371591 |
9 | NADH dehydrogenase complex assembly (GO:0010257) | 4.49371591 |
10 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.42232298 |
11 | termination of RNA polymerase III transcription (GO:0006386) | 4.42232298 |
12 | protein complex biogenesis (GO:0070271) | 4.41589467 |
13 | electron transport chain (GO:0022900) | 4.40554422 |
14 | purine nucleobase biosynthetic process (GO:0009113) | 4.30336222 |
15 | guanosine-containing compound biosynthetic process (GO:1901070) | 4.22852391 |
16 | regulation of mitochondrial translation (GO:0070129) | 4.19351450 |
17 | cullin deneddylation (GO:0010388) | 4.18595952 |
18 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.18179968 |
19 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.11754661 |
20 | 7-methylguanosine mRNA capping (GO:0006370) | 4.07470191 |
21 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.06819520 |
22 | maturation of SSU-rRNA (GO:0030490) | 4.06578209 |
23 | nucleobase biosynthetic process (GO:0046112) | 4.05869543 |
24 | RNA capping (GO:0036260) | 4.04418625 |
25 | 7-methylguanosine RNA capping (GO:0009452) | 4.04418625 |
26 | respiratory chain complex IV assembly (GO:0008535) | 4.00180221 |
27 | maturation of 5.8S rRNA (GO:0000460) | 3.93373329 |
28 | protein deneddylation (GO:0000338) | 3.92811706 |
29 | DNA deamination (GO:0045006) | 3.92727020 |
30 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.92417623 |
31 | GTP biosynthetic process (GO:0006183) | 3.89457156 |
32 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.86895771 |
33 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.83087616 |
34 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.81651475 |
35 | amino acid salvage (GO:0043102) | 3.74648970 |
36 | L-methionine salvage (GO:0071267) | 3.74648970 |
37 | L-methionine biosynthetic process (GO:0071265) | 3.74648970 |
38 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.70092411 |
39 | rRNA modification (GO:0000154) | 3.69385671 |
40 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.66224075 |
41 | negative regulation of ligase activity (GO:0051352) | 3.66224075 |
42 | chaperone-mediated protein transport (GO:0072321) | 3.57816107 |
43 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.56881712 |
44 | spliceosomal snRNP assembly (GO:0000387) | 3.54101425 |
45 | cytochrome complex assembly (GO:0017004) | 3.53316688 |
46 | pseudouridine synthesis (GO:0001522) | 3.52239193 |
47 | termination of RNA polymerase I transcription (GO:0006363) | 3.51275146 |
48 | replication fork processing (GO:0031297) | 3.50468489 |
49 | NADH metabolic process (GO:0006734) | 3.50203177 |
50 | oxidative phosphorylation (GO:0006119) | 3.50052193 |
51 | UTP biosynthetic process (GO:0006228) | 3.50017914 |
52 | cellular ketone body metabolic process (GO:0046950) | 3.49379633 |
53 | GMP metabolic process (GO:0046037) | 3.47381279 |
54 | protein neddylation (GO:0045116) | 3.46800913 |
55 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.46049127 |
56 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.44761558 |
57 | nonmotile primary cilium assembly (GO:0035058) | 3.43969248 |
58 | establishment of protein localization to mitochondrion (GO:0072655) | 3.43014983 |
59 | transcription from RNA polymerase I promoter (GO:0006360) | 3.41530718 |
60 | cellular component biogenesis (GO:0044085) | 3.40857322 |
61 | DNA replication checkpoint (GO:0000076) | 3.40112038 |
62 | protein targeting to mitochondrion (GO:0006626) | 3.38762436 |
63 | protein K6-linked ubiquitination (GO:0085020) | 3.38706242 |
64 | translation (GO:0006412) | 3.36090294 |
65 | positive regulation of ligase activity (GO:0051351) | 3.35689882 |
66 | ribosome biogenesis (GO:0042254) | 3.34427369 |
67 | DNA double-strand break processing (GO:0000729) | 3.33767591 |
68 | ribosomal large subunit biogenesis (GO:0042273) | 3.33244915 |
69 | chromatin remodeling at centromere (GO:0031055) | 3.31069289 |
70 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.29273758 |
71 | behavioral response to nicotine (GO:0035095) | 3.28667160 |
72 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.27578986 |
73 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.26309919 |
74 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.25940832 |
75 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.24874032 |
76 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.24874032 |
77 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.24874032 |
78 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.23798713 |
79 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.23798713 |
80 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.21142494 |
81 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.21142494 |
82 | platelet dense granule organization (GO:0060155) | 3.19130489 |
83 | protein localization to mitochondrion (GO:0070585) | 3.18798789 |
84 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.17583611 |
85 | ribosomal small subunit assembly (GO:0000028) | 3.17128888 |
86 | peptidyl-histidine modification (GO:0018202) | 3.16868952 |
87 | formation of translation preinitiation complex (GO:0001731) | 3.16132249 |
88 | resolution of meiotic recombination intermediates (GO:0000712) | 3.15946056 |
89 | * protein-cofactor linkage (GO:0018065) | 3.14998931 |
90 | CTP biosynthetic process (GO:0006241) | 3.13042478 |
91 | CTP metabolic process (GO:0046036) | 3.13042478 |
92 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.12817189 |
93 | regulation of hexokinase activity (GO:1903299) | 3.12769735 |
94 | regulation of glucokinase activity (GO:0033131) | 3.12769735 |
95 | UTP metabolic process (GO:0046051) | 3.11702826 |
96 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.11682943 |
97 | ketone body metabolic process (GO:1902224) | 3.08893803 |
98 | CENP-A containing nucleosome assembly (GO:0034080) | 3.08733269 |
99 | rRNA processing (GO:0006364) | 3.07187065 |
100 | rRNA methylation (GO:0031167) | 3.06778674 |
101 | quinone biosynthetic process (GO:1901663) | 3.06533292 |
102 | ubiquinone biosynthetic process (GO:0006744) | 3.06533292 |
103 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.05924586 |
104 | centriole replication (GO:0007099) | 3.04709468 |
105 | spliceosomal complex assembly (GO:0000245) | 3.04588013 |
106 | piRNA metabolic process (GO:0034587) | 3.03304625 |
107 | synapsis (GO:0007129) | 3.03098954 |
108 | cotranslational protein targeting to membrane (GO:0006613) | 3.02593480 |
109 | metallo-sulfur cluster assembly (GO:0031163) | 3.01457177 |
110 | iron-sulfur cluster assembly (GO:0016226) | 3.01457177 |
111 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.01408782 |
112 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.01408782 |
113 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.01270816 |
114 | DNA damage response, detection of DNA damage (GO:0042769) | 3.01098350 |
115 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.01067466 |
116 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.00997760 |
117 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.00724317 |
118 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.00502045 |
119 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.00502045 |
120 | recombinational repair (GO:0000725) | 3.00150871 |
121 | ribosomal small subunit biogenesis (GO:0042274) | 2.99802806 |
122 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.99474673 |
123 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.99290389 |
124 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.98768508 |
125 | double-strand break repair via homologous recombination (GO:0000724) | 2.94953159 |
126 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.92337271 |
127 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.91620559 |
128 | response to pheromone (GO:0019236) | 2.91478587 |
129 | intracellular protein transmembrane import (GO:0044743) | 2.87534505 |
130 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.87452913 |
131 | mannosylation (GO:0097502) | 2.77882844 |
132 | reciprocal DNA recombination (GO:0035825) | 2.77398725 |
133 | reciprocal meiotic recombination (GO:0007131) | 2.77398725 |
134 | meiotic chromosome segregation (GO:0045132) | 2.75566969 |
135 | tRNA processing (GO:0008033) | 2.75316805 |
136 | histone exchange (GO:0043486) | 2.73632861 |
137 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.72318380 |
138 | mitochondrial RNA metabolic process (GO:0000959) | 2.71694907 |
139 | regulation of cilium movement (GO:0003352) | 2.71037455 |
140 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.65557716 |
141 | negative regulation of telomere maintenance (GO:0032205) | 2.64710648 |
142 | regulation of meiosis I (GO:0060631) | 2.63873904 |
143 | male meiosis I (GO:0007141) | 2.62377771 |
144 | organelle disassembly (GO:1903008) | 2.62354436 |
145 | cornea development in camera-type eye (GO:0061303) | 2.60298759 |
146 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.58648498 |
147 | ubiquinone metabolic process (GO:0006743) | 2.56945505 |
148 | epithelial cilium movement (GO:0003351) | 2.53886373 |
149 | neural tube formation (GO:0001841) | 2.52075863 |
150 | rRNA catabolic process (GO:0016075) | 2.49823141 |
151 | postreplication repair (GO:0006301) | 2.47497726 |
152 | axoneme assembly (GO:0035082) | 2.47125170 |
153 | fucose catabolic process (GO:0019317) | 2.46421321 |
154 | L-fucose metabolic process (GO:0042354) | 2.46421321 |
155 | L-fucose catabolic process (GO:0042355) | 2.46421321 |
156 | inner mitochondrial membrane organization (GO:0007007) | 2.45285594 |
157 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.44924517 |
158 | isotype switching (GO:0045190) | 2.44924517 |
159 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.44924517 |
160 | photoreceptor cell maintenance (GO:0045494) | 2.44764828 |
161 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.44684060 |
162 | detection of light stimulus involved in visual perception (GO:0050908) | 2.44684060 |
163 | translational termination (GO:0006415) | 2.42830280 |
164 | hydrogen ion transmembrane transport (GO:1902600) | 2.42271852 |
165 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.41603132 |
166 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.41603132 |
167 | cilium morphogenesis (GO:0060271) | 2.38416557 |
168 | tRNA metabolic process (GO:0006399) | 2.37701280 |
169 | ATP biosynthetic process (GO:0006754) | 2.37266702 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.12861770 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.39379575 |
3 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.35240318 |
4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.16907491 |
5 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.93630073 |
6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.86181562 |
7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.82750612 |
8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.73121843 |
9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.66771007 |
10 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.35197949 |
11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.20436928 |
12 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.10817626 |
13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.07926804 |
14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.00796898 |
15 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.97526119 |
16 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.91665768 |
17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.87849211 |
18 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.72072952 |
19 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.69030308 |
20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.65211361 |
21 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.63847531 |
22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.57530305 |
23 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.52797830 |
24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.52381301 |
25 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.50629322 |
26 | EWS_26573619_Chip-Seq_HEK293_Human | 2.39255108 |
27 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.38728361 |
28 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.37190193 |
29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.35109395 |
30 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.28996953 |
31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.24171716 |
32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.22531411 |
33 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.16787445 |
34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.15915045 |
35 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.13567317 |
36 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.09809649 |
37 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.09788836 |
38 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.09572472 |
39 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.06914106 |
40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.05445219 |
41 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.04423353 |
42 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.03395451 |
43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.02848268 |
44 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.97858192 |
45 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.96501043 |
46 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.94055553 |
47 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.93699193 |
48 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.90055238 |
49 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.87573681 |
50 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.85117814 |
51 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.80799891 |
52 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.74869058 |
53 | P300_19829295_ChIP-Seq_ESCs_Human | 1.70943954 |
54 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.70148643 |
55 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.70086989 |
56 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.69783285 |
57 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.66644118 |
58 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.63073969 |
59 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.59901998 |
60 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.59468841 |
61 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.56108926 |
62 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.54865876 |
63 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.53962077 |
64 | * TP53_22573176_ChIP-Seq_HFKS_Human | 1.51499151 |
65 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.51211534 |
66 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.47170395 |
67 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.44488910 |
68 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.41227592 |
69 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40905056 |
70 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.37587128 |
71 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.36386752 |
72 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.36359426 |
73 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.35559062 |
74 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.33526433 |
75 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.29627215 |
76 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.29627215 |
77 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.27646753 |
78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.23577451 |
79 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.23263287 |
80 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.23263287 |
81 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.22602146 |
82 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.22291102 |
83 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21442649 |
84 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.20499874 |
85 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.19938519 |
86 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.19824758 |
87 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.19703637 |
88 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.19312640 |
89 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.18565958 |
90 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.18317641 |
91 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.17513134 |
92 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.17484044 |
93 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.17484044 |
94 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.17233146 |
95 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.13257085 |
96 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.10176402 |
97 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.09519960 |
98 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.07989563 |
99 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.07210939 |
100 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.06009209 |
101 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.05927553 |
102 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.04529367 |
103 | AR_20517297_ChIP-Seq_VCAP_Human | 1.04400591 |
104 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04178453 |
105 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.03685511 |
106 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.03591864 |
107 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.02961155 |
108 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.02870730 |
109 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.02144428 |
110 | TCF4_23295773_ChIP-Seq_U87_Human | 1.01503910 |
111 | AR_25329375_ChIP-Seq_VCAP_Human | 1.01399860 |
112 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.01281408 |
113 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.99318480 |
114 | NCOR_22424771_ChIP-Seq_293T_Human | 0.98685061 |
115 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.98600492 |
116 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.97803733 |
117 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.97417763 |
118 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.96630420 |
119 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.96162891 |
120 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.95744900 |
121 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.95188906 |
122 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.94962485 |
123 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.94660942 |
124 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.93486057 |
125 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.93210146 |
126 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.92844597 |
127 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.92638467 |
128 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.92433619 |
129 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.92323258 |
130 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92142144 |
131 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.91564646 |
132 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.91541414 |
133 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.91148644 |
134 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.90047942 |
135 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.89954575 |
136 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.89809055 |
137 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.89150752 |
138 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.88980806 |
139 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.88758238 |
140 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88756888 |
141 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.87536439 |
142 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86675012 |
143 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.86512868 |
144 | VDR_22108803_ChIP-Seq_LS180_Human | 0.86383378 |
145 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.86329855 |
146 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.85388715 |
147 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.81304566 |
148 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.80313397 |
149 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.77685241 |
150 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.76864231 |
151 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.75991905 |
152 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.75978240 |
153 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.75544503 |
154 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.74488511 |
155 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.72688798 |
156 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.71987420 |
157 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.66794699 |
158 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.66158136 |
159 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.64976963 |
160 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.64619507 |
161 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.64472881 |
162 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.64261269 |
163 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.63229510 |
164 | FUS_26573619_Chip-Seq_HEK293_Human | 0.63185249 |
165 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.62981280 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 4.37769108 |
2 | MP0006036_abnormal_mitochondrial_physio | 3.34016254 |
3 | MP0003806_abnormal_nucleotide_metabolis | 3.21553225 |
4 | MP0004957_abnormal_blastocyst_morpholog | 3.07080515 |
5 | MP0008058_abnormal_DNA_repair | 2.94305149 |
6 | MP0002837_dystrophic_cardiac_calcinosis | 2.93878141 |
7 | MP0009379_abnormal_foot_pigmentation | 2.70343690 |
8 | MP0004147_increased_porphyrin_level | 2.65802364 |
9 | MP0010094_abnormal_chromosome_stability | 2.61434961 |
10 | MP0001529_abnormal_vocalization | 2.57655935 |
11 | MP0009697_abnormal_copulation | 2.55433068 |
12 | MP0003111_abnormal_nucleus_morphology | 2.49358779 |
13 | MP0003718_maternal_effect | 2.42281011 |
14 | MP0006035_abnormal_mitochondrial_morpho | 2.26634469 |
15 | MP0003787_abnormal_imprinting | 2.26622984 |
16 | MP0002102_abnormal_ear_morphology | 2.26156718 |
17 | MP0008057_abnormal_DNA_replication | 2.19402858 |
18 | MP0005551_abnormal_eye_electrophysiolog | 2.15760281 |
19 | MP0003077_abnormal_cell_cycle | 1.96984961 |
20 | MP0002163_abnormal_gland_morphology | 1.95630180 |
21 | MP0002139_abnormal_hepatobiliary_system | 1.88546186 |
22 | MP0001986_abnormal_taste_sensitivity | 1.86954962 |
23 | MP0003123_paternal_imprinting | 1.85259172 |
24 | MP0003195_calcinosis | 1.81954003 |
25 | MP0000372_irregular_coat_pigmentation | 1.80539147 |
26 | MP0000569_abnormal_digit_pigmentation | 1.80392335 |
27 | * MP0001764_abnormal_homeostasis | 1.79031363 |
28 | MP0003186_abnormal_redox_activity | 1.76445461 |
29 | MP0001905_abnormal_dopamine_level | 1.72994935 |
30 | MP0008932_abnormal_embryonic_tissue | 1.68691369 |
31 | MP0005253_abnormal_eye_physiology | 1.65511172 |
32 | MP0006276_abnormal_autonomic_nervous | 1.64929400 |
33 | MP0003121_genomic_imprinting | 1.63385797 |
34 | MP0008789_abnormal_olfactory_epithelium | 1.61667950 |
35 | MP0001188_hyperpigmentation | 1.61355151 |
36 | MP0003646_muscle_fatigue | 1.57906385 |
37 | MP0000631_abnormal_neuroendocrine_gland | 1.57771279 |
38 | MP0004215_abnormal_myocardial_fiber | 1.57189621 |
39 | MP0002277_abnormal_respiratory_mucosa | 1.56878134 |
40 | MP0005646_abnormal_pituitary_gland | 1.55532747 |
41 | MP0005379_endocrine/exocrine_gland_phen | 1.54615187 |
42 | MP0002876_abnormal_thyroid_physiology | 1.53770802 |
43 | MP0004133_heterotaxia | 1.50774457 |
44 | MP0008872_abnormal_physiological_respon | 1.50733531 |
45 | MP0008995_early_reproductive_senescence | 1.49599714 |
46 | MP0004885_abnormal_endolymph | 1.46350020 |
47 | MP0003786_premature_aging | 1.43705810 |
48 | MP0002928_abnormal_bile_duct | 1.43552255 |
49 | MP0002638_abnormal_pupillary_reflex | 1.41156976 |
50 | MP0008877_abnormal_DNA_methylation | 1.40533543 |
51 | MP0004084_abnormal_cardiac_muscle | 1.40375587 |
52 | MP0008875_abnormal_xenobiotic_pharmacok | 1.32786483 |
53 | MP0001293_anophthalmia | 1.29984694 |
54 | MP0003656_abnormal_erythrocyte_physiolo | 1.29257821 |
55 | MP0005330_cardiomyopathy | 1.28900700 |
56 | MP0001984_abnormal_olfaction | 1.28382868 |
57 | MP0001968_abnormal_touch/_nociception | 1.28156092 |
58 | MP0005174_abnormal_tail_pigmentation | 1.27761649 |
59 | MP0005645_abnormal_hypothalamus_physiol | 1.27696593 |
60 | MP0005085_abnormal_gallbladder_physiolo | 1.27222008 |
61 | MP0002160_abnormal_reproductive_system | 1.27033929 |
62 | MP0009046_muscle_twitch | 1.24029237 |
63 | MP0000749_muscle_degeneration | 1.23188578 |
64 | MP0002653_abnormal_ependyma_morphology | 1.22801708 |
65 | MP0000427_abnormal_hair_cycle | 1.22705171 |
66 | MP0005332_abnormal_amino_acid | 1.21926526 |
67 | MP0006292_abnormal_olfactory_placode | 1.21912446 |
68 | MP0008260_abnormal_autophagy | 1.21243782 |
69 | MP0001661_extended_life_span | 1.20718313 |
70 | MP0004145_abnormal_muscle_electrophysio | 1.20005730 |
71 | MP0005451_abnormal_body_composition | 1.19049077 |
72 | MP0004043_abnormal_pH_regulation | 1.18416590 |
73 | MP0005266_abnormal_metabolism | 1.17337958 |
74 | MP0004036_abnormal_muscle_relaxation | 1.15534166 |
75 | MP0002234_abnormal_pharynx_morphology | 1.15514292 |
76 | MP0004742_abnormal_vestibular_system | 1.14707224 |
77 | MP0005075_abnormal_melanosome_morpholog | 1.14237590 |
78 | MP0003221_abnormal_cardiomyocyte_apopto | 1.14060083 |
79 | MP0004142_abnormal_muscle_tone | 1.12462197 |
80 | MP0010386_abnormal_urinary_bladder | 1.11538378 |
81 | MP0002736_abnormal_nociception_after | 1.11007010 |
82 | MP0005365_abnormal_bile_salt | 1.08256110 |
83 | MP0005394_taste/olfaction_phenotype | 1.07335552 |
84 | MP0005499_abnormal_olfactory_system | 1.07335552 |
85 | MP0009745_abnormal_behavioral_response | 1.07289574 |
86 | MP0005389_reproductive_system_phenotype | 1.06815395 |
87 | MP0001929_abnormal_gametogenesis | 1.06788175 |
88 | MP0002210_abnormal_sex_determination | 1.06641995 |
89 | MP0005636_abnormal_mineral_homeostasis | 1.06238719 |
90 | MP0001542_abnormal_bone_strength | 1.05200322 |
91 | MP0002095_abnormal_skin_pigmentation | 1.04560257 |
92 | MP0000013_abnormal_adipose_tissue | 1.02310792 |
93 | MP0000647_abnormal_sebaceous_gland | 1.02294269 |
94 | MP0001486_abnormal_startle_reflex | 1.00971186 |
95 | MP0008007_abnormal_cellular_replicative | 1.00852521 |
96 | MP0003890_abnormal_embryonic-extraembry | 0.99327628 |
97 | MP0000358_abnormal_cell_content/ | 0.98435495 |
98 | MP0006072_abnormal_retinal_apoptosis | 0.97088230 |
99 | MP0005195_abnormal_posterior_eye | 0.96252281 |
100 | MP0005410_abnormal_fertilization | 0.95986186 |
101 | MP0003879_abnormal_hair_cell | 0.94820365 |
102 | MP0003880_abnormal_central_pattern | 0.93539749 |
103 | MP0002138_abnormal_hepatobiliary_system | 0.92842366 |
104 | MP0001145_abnormal_male_reproductive | 0.91220471 |
105 | MP0003698_abnormal_male_reproductive | 0.90383677 |
106 | MP0000747_muscle_weakness | 0.87831238 |
107 | * MP0001730_embryonic_growth_arrest | 0.87791196 |
108 | MP0002735_abnormal_chemical_nociception | 0.86421578 |
109 | MP0002557_abnormal_social/conspecific_i | 0.85685035 |
110 | MP0002938_white_spotting | 0.85051927 |
111 | MP0001485_abnormal_pinna_reflex | 0.84729378 |
112 | MP0002332_abnormal_exercise_endurance | 0.84635336 |
113 | MP0005220_abnormal_exocrine_pancreas | 0.83671827 |
114 | MP0001119_abnormal_female_reproductive | 0.82864353 |
115 | MP0003136_yellow_coat_color | 0.80864863 |
116 | MP0005084_abnormal_gallbladder_morpholo | 0.80280643 |
117 | MP0000026_abnormal_inner_ear | 0.79961869 |
118 | MP0000778_abnormal_nervous_system | 0.79478686 |
119 | MP0003137_abnormal_impulse_conducting | 0.79374430 |
120 | MP0001324_abnormal_eye_pigmentation | 0.78638752 |
121 | MP0000653_abnormal_sex_gland | 0.78483579 |
122 | MP0005319_abnormal_enzyme/_coenzyme | 0.78249674 |
123 | MP0002272_abnormal_nervous_system | 0.78140471 |
124 | MP0005391_vision/eye_phenotype | 0.78064078 |
125 | MP0005423_abnormal_somatic_nervous | 0.77285382 |
126 | MP0002752_abnormal_somatic_nervous | 0.76734060 |
127 | MP0003315_abnormal_perineum_morphology | 0.76628469 |
128 | MP0008775_abnormal_heart_ventricle | 0.76556468 |
129 | MP0001919_abnormal_reproductive_system | 0.75454846 |
130 | * MP0005376_homeostasis/metabolism_phenot | 0.75207783 |
131 | MP0001501_abnormal_sleep_pattern | 0.74796982 |
132 | MP0003937_abnormal_limbs/digits/tail_de | 0.74598796 |
133 | MP0005535_abnormal_body_temperature | 0.74560039 |
134 | MP0002269_muscular_atrophy | 0.74192206 |
135 | MP0009333_abnormal_splenocyte_physiolog | 0.68378726 |
136 | MP0005409_darkened_coat_color | 0.68378413 |
137 | MP0005360_urolithiasis | 0.67620444 |
138 | MP0002078_abnormal_glucose_homeostasis | 0.67597249 |
139 | MP0003122_maternal_imprinting | 0.67359903 |
140 | MP0002693_abnormal_pancreas_physiology | 0.66532389 |
141 | MP0002734_abnormal_mechanical_nocicepti | 0.65870395 |
142 | MP0002127_abnormal_cardiovascular_syste | 0.64111536 |
143 | MP0005670_abnormal_white_adipose | 0.63925898 |
144 | MP0003567_abnormal_fetal_cardiomyocyte | 0.63912949 |
145 | MP0001440_abnormal_grooming_behavior | 0.63087664 |
146 | MP0003011_delayed_dark_adaptation | 0.62176763 |
147 | MP0004019_abnormal_vitamin_homeostasis | 0.60521771 |
148 | MP0000015_abnormal_ear_pigmentation | 0.59183018 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 5.45835751 |
2 | Hepatocellular necrosis (HP:0001404) | 5.07693335 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.04620681 |
4 | Mitochondrial inheritance (HP:0001427) | 4.99834699 |
5 | Hepatic necrosis (HP:0002605) | 4.91365585 |
6 | Acute encephalopathy (HP:0006846) | 4.77554152 |
7 | Increased CSF lactate (HP:0002490) | 4.77393437 |
8 | Abnormality of glycolysis (HP:0004366) | 4.57661384 |
9 | Increased serum pyruvate (HP:0003542) | 4.57661384 |
10 | Progressive macrocephaly (HP:0004481) | 4.46215342 |
11 | Cerebral edema (HP:0002181) | 3.79906465 |
12 | * Increased serum lactate (HP:0002151) | 3.70637429 |
13 | Molar tooth sign on MRI (HP:0002419) | 3.61644028 |
14 | Abnormality of midbrain morphology (HP:0002418) | 3.61644028 |
15 | Increased hepatocellular lipid droplets (HP:0006565) | 3.58448284 |
16 | * Lactic acidosis (HP:0003128) | 3.49057497 |
17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.48631752 |
18 | 3-Methylglutaconic aciduria (HP:0003535) | 3.42622060 |
19 | Hyperglycinemia (HP:0002154) | 3.38556404 |
20 | Respiratory failure (HP:0002878) | 3.25227587 |
21 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.22936976 |
22 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.22936976 |
23 | Exercise intolerance (HP:0003546) | 3.19056232 |
24 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.17298907 |
25 | Abnormality of alanine metabolism (HP:0010916) | 3.17298907 |
26 | Hyperalaninemia (HP:0003348) | 3.17298907 |
27 | Nephronophthisis (HP:0000090) | 3.13923022 |
28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.09299698 |
29 | Microvesicular hepatic steatosis (HP:0001414) | 3.05139564 |
30 | Birth length less than 3rd percentile (HP:0003561) | 3.03253129 |
31 | CNS demyelination (HP:0007305) | 2.96931750 |
32 | Renal Fanconi syndrome (HP:0001994) | 2.94909580 |
33 | Cerebral hypomyelination (HP:0006808) | 2.94876795 |
34 | Increased intramyocellular lipid droplets (HP:0012240) | 2.91103349 |
35 | Hyperglycinuria (HP:0003108) | 2.89630375 |
36 | Lethargy (HP:0001254) | 2.88457403 |
37 | Abnormality of the labia minora (HP:0012880) | 2.79647944 |
38 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.79201257 |
39 | Increased muscle lipid content (HP:0009058) | 2.77033663 |
40 | Abnormality of serum amino acid levels (HP:0003112) | 2.75295184 |
41 | Optic disc pallor (HP:0000543) | 2.73293744 |
42 | Congenital stationary night blindness (HP:0007642) | 2.72972385 |
43 | Type II lissencephaly (HP:0007260) | 2.71306524 |
44 | Abnormality of the renal cortex (HP:0011035) | 2.70744069 |
45 | Abnormality of the renal medulla (HP:0100957) | 2.70739442 |
46 | Abnormality of glycine metabolism (HP:0010895) | 2.68623340 |
47 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.68623340 |
48 | Leukodystrophy (HP:0002415) | 2.59546148 |
49 | Methylmalonic aciduria (HP:0012120) | 2.56574935 |
50 | Dicarboxylic aciduria (HP:0003215) | 2.56493229 |
51 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.56493229 |
52 | Emotional lability (HP:0000712) | 2.52572935 |
53 | Pendular nystagmus (HP:0012043) | 2.52372507 |
54 | Macrocytic anemia (HP:0001972) | 2.49879080 |
55 | Pancreatic fibrosis (HP:0100732) | 2.49458394 |
56 | Respiratory difficulties (HP:0002880) | 2.47700358 |
57 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.41624545 |
58 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.38237288 |
59 | Type I transferrin isoform profile (HP:0003642) | 2.36929510 |
60 | Neuroendocrine neoplasm (HP:0100634) | 2.34135811 |
61 | Nephrogenic diabetes insipidus (HP:0009806) | 2.33817060 |
62 | Cystic liver disease (HP:0006706) | 2.31683417 |
63 | Abnormal number of erythroid precursors (HP:0012131) | 2.30459222 |
64 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.28283509 |
65 | Sclerocornea (HP:0000647) | 2.27166187 |
66 | Pancreatic cysts (HP:0001737) | 2.26377035 |
67 | Attenuation of retinal blood vessels (HP:0007843) | 2.25657863 |
68 | Genital tract atresia (HP:0001827) | 2.23771425 |
69 | Chronic hepatic failure (HP:0100626) | 2.23710627 |
70 | Megaloblastic anemia (HP:0001889) | 2.21196865 |
71 | Oral leukoplakia (HP:0002745) | 2.17888904 |
72 | Breast hypoplasia (HP:0003187) | 2.17580281 |
73 | Septo-optic dysplasia (HP:0100842) | 2.15644784 |
74 | Abnormal pupillary function (HP:0007686) | 2.15439196 |
75 | Optic nerve hypoplasia (HP:0000609) | 2.13146122 |
76 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.11842788 |
77 | Glycosuria (HP:0003076) | 2.11574626 |
78 | Abnormality of urine glucose concentration (HP:0011016) | 2.11574626 |
79 | Exertional dyspnea (HP:0002875) | 2.10449624 |
80 | Degeneration of anterior horn cells (HP:0002398) | 2.07998886 |
81 | Abnormality of the anterior horn cell (HP:0006802) | 2.07998886 |
82 | Pheochromocytoma (HP:0002666) | 2.06828821 |
83 | Methylmalonic acidemia (HP:0002912) | 2.05948304 |
84 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.05424119 |
85 | Abolished electroretinogram (ERG) (HP:0000550) | 2.04977378 |
86 | Abnormality of renal resorption (HP:0011038) | 2.04775813 |
87 | Chromsome breakage (HP:0040012) | 2.03991896 |
88 | Vaginal atresia (HP:0000148) | 2.03984519 |
89 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.03505633 |
90 | Colon cancer (HP:0003003) | 2.02973352 |
91 | Rough bone trabeculation (HP:0100670) | 2.02503906 |
92 | Unsteady gait (HP:0002317) | 2.00854838 |
93 | Gliosis (HP:0002171) | 2.00793973 |
94 | Furrowed tongue (HP:0000221) | 2.00092033 |
95 | Hypothermia (HP:0002045) | 1.99942421 |
96 | Postaxial foot polydactyly (HP:0001830) | 1.99838833 |
97 | Medial flaring of the eyebrow (HP:0010747) | 1.99246467 |
98 | Abnormal drinking behavior (HP:0030082) | 1.99187163 |
99 | Polydipsia (HP:0001959) | 1.99187163 |
100 | Meckel diverticulum (HP:0002245) | 1.99144695 |
101 | CNS hypomyelination (HP:0003429) | 1.98951178 |
102 | Palpitations (HP:0001962) | 1.95431430 |
103 | Abnormality of chromosome stability (HP:0003220) | 1.94238840 |
104 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.94175813 |
105 | Abnormality of the ileum (HP:0001549) | 1.94130068 |
106 | Anencephaly (HP:0002323) | 1.93747555 |
107 | Secondary amenorrhea (HP:0000869) | 1.93249468 |
108 | Cerebellar dysplasia (HP:0007033) | 1.92411032 |
109 | Aplastic anemia (HP:0001915) | 1.92104794 |
110 | Congenital, generalized hypertrichosis (HP:0004540) | 1.90182092 |
111 | Proximal tubulopathy (HP:0000114) | 1.89777907 |
112 | Abnormal biliary tract physiology (HP:0012439) | 1.89441562 |
113 | Bile duct proliferation (HP:0001408) | 1.89441562 |
114 | Sloping forehead (HP:0000340) | 1.89314687 |
115 | Male pseudohermaphroditism (HP:0000037) | 1.87644565 |
116 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.86990409 |
117 | Tubular atrophy (HP:0000092) | 1.86032956 |
118 | Abnormal protein glycosylation (HP:0012346) | 1.85864886 |
119 | Abnormal glycosylation (HP:0012345) | 1.85864886 |
120 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.85864886 |
121 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.85864886 |
122 | Progressive external ophthalmoplegia (HP:0000590) | 1.84842829 |
123 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.83450237 |
124 | Congenital hepatic fibrosis (HP:0002612) | 1.83133545 |
125 | Short tibia (HP:0005736) | 1.82441233 |
126 | Delusions (HP:0000746) | 1.81935011 |
127 | Volvulus (HP:0002580) | 1.81262946 |
128 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.80890562 |
129 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.80890562 |
130 | Congenital primary aphakia (HP:0007707) | 1.79767115 |
131 | True hermaphroditism (HP:0010459) | 1.79167079 |
132 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.79166708 |
133 | Hyperphosphaturia (HP:0003109) | 1.78106650 |
134 | Reduced antithrombin III activity (HP:0001976) | 1.77994145 |
135 | Abnormality of vitamin B metabolism (HP:0004340) | 1.77839754 |
136 | Poor coordination (HP:0002370) | 1.77178038 |
137 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.76981041 |
138 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.76773202 |
139 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.76689945 |
140 | Prolonged neonatal jaundice (HP:0006579) | 1.76055632 |
141 | Renal cortical cysts (HP:0000803) | 1.75719873 |
142 | Reticulocytopenia (HP:0001896) | 1.73362484 |
143 | Gait imbalance (HP:0002141) | 1.73150847 |
144 | Retinal dysplasia (HP:0007973) | 1.72218339 |
145 | Nausea (HP:0002018) | 1.71999517 |
146 | Progressive muscle weakness (HP:0003323) | 1.71690608 |
147 | Pancytopenia (HP:0001876) | 1.71334116 |
148 | Vomiting (HP:0002013) | 1.71152195 |
149 | Oculomotor apraxia (HP:0000657) | 1.69716403 |
150 | Abnormality of the pons (HP:0007361) | 1.69635769 |
151 | Hypoplasia of the pons (HP:0012110) | 1.69525320 |
152 | Small hand (HP:0200055) | 1.67916943 |
153 | Postaxial hand polydactyly (HP:0001162) | 1.67373437 |
154 | Chorioretinal atrophy (HP:0000533) | 1.66530126 |
155 | Inability to walk (HP:0002540) | 1.65520124 |
156 | Absent thumb (HP:0009777) | 1.65178489 |
157 | Stenosis of the external auditory canal (HP:0000402) | 1.64122696 |
158 | Decreased central vision (HP:0007663) | 1.63956082 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 4.22221967 |
2 | STK16 | 3.90277424 |
3 | WEE1 | 3.79329442 |
4 | FRK | 3.37886710 |
5 | EIF2AK1 | 3.20766693 |
6 | NME2 | 2.86467519 |
7 | BCKDK | 2.60179476 |
8 | NME1 | 2.53155569 |
9 | PNCK | 2.38969207 |
10 | BRSK2 | 2.33936367 |
11 | PDK3 | 2.28571055 |
12 | PDK4 | 2.28571055 |
13 | SRPK1 | 2.27363773 |
14 | NUAK1 | 2.23726766 |
15 | TLK1 | 2.20802355 |
16 | AKT3 | 2.19690726 |
17 | TSSK6 | 2.16906838 |
18 | MAP4K2 | 2.09935909 |
19 | EIF2AK3 | 2.04197676 |
20 | ARAF | 1.95284825 |
21 | VRK1 | 1.91857796 |
22 | INSRR | 1.85245367 |
23 | PLK4 | 1.79974375 |
24 | TAOK3 | 1.78615273 |
25 | CCNB1 | 1.75971940 |
26 | BRAF | 1.66934505 |
27 | VRK2 | 1.65858041 |
28 | STK39 | 1.63488305 |
29 | MAP3K12 | 1.63174864 |
30 | PLK3 | 1.61664953 |
31 | CASK | 1.60656806 |
32 | BRSK1 | 1.60357562 |
33 | ACVR1B | 1.56276332 |
34 | CDC7 | 1.47025493 |
35 | TRIM28 | 1.43841304 |
36 | DYRK3 | 1.37570300 |
37 | PLK1 | 1.29004889 |
38 | MKNK2 | 1.20827724 |
39 | MYLK | 1.15573560 |
40 | OBSCN | 1.10177100 |
41 | AURKA | 1.10071754 |
42 | NEK1 | 1.09408491 |
43 | PDK2 | 1.09017132 |
44 | ZAK | 1.07750906 |
45 | PHKG1 | 1.04429821 |
46 | PHKG2 | 1.04429821 |
47 | PIM2 | 1.04350281 |
48 | STK38L | 1.03834336 |
49 | CDK3 | 1.02432094 |
50 | WNK3 | 0.98193587 |
51 | MAP2K7 | 0.95310933 |
52 | PINK1 | 0.95162401 |
53 | DYRK2 | 0.93654724 |
54 | NEK2 | 0.93019281 |
55 | TGFBR1 | 0.91801582 |
56 | TTK | 0.91196322 |
57 | BMPR1B | 0.90895448 |
58 | IRAK3 | 0.88092800 |
59 | MKNK1 | 0.87548902 |
60 | AURKB | 0.83019365 |
61 | CSNK2A1 | 0.81405687 |
62 | NTRK3 | 0.80608453 |
63 | CSNK2A2 | 0.77740157 |
64 | GRK7 | 0.76290811 |
65 | PASK | 0.75571970 |
66 | TAF1 | 0.75278415 |
67 | ERBB3 | 0.75247827 |
68 | CSNK1G3 | 0.74392522 |
69 | CDK8 | 0.73708095 |
70 | EIF2AK2 | 0.72498160 |
71 | RPS6KA5 | 0.72158626 |
72 | TXK | 0.70212663 |
73 | MUSK | 0.67250690 |
74 | PBK | 0.65941923 |
75 | MAPK15 | 0.65323359 |
76 | NLK | 0.64689097 |
77 | PIK3CG | 0.61897482 |
78 | CSNK1G1 | 0.59972164 |
79 | CHEK2 | 0.59892991 |
80 | PAK3 | 0.59709425 |
81 | STK24 | 0.59540027 |
82 | CAMK2G | 0.58995309 |
83 | BMPR2 | 0.58431009 |
84 | PRKCG | 0.58116581 |
85 | CAMK2D | 0.55287384 |
86 | OXSR1 | 0.54128292 |
87 | ADRBK1 | 0.54032352 |
88 | PIK3CA | 0.54029877 |
89 | STK3 | 0.53326540 |
90 | CAMKK2 | 0.52904870 |
91 | MAPK13 | 0.52515995 |
92 | PKN1 | 0.52416634 |
93 | MARK1 | 0.52390817 |
94 | CDK19 | 0.52275168 |
95 | MAPKAPK5 | 0.51866284 |
96 | ATR | 0.51722830 |
97 | EPHA2 | 0.50887841 |
98 | CAMK2B | 0.49934004 |
99 | EPHA4 | 0.49479129 |
100 | RPS6KA4 | 0.48855564 |
101 | TIE1 | 0.48702183 |
102 | PRKCQ | 0.48632326 |
103 | WNK4 | 0.47555446 |
104 | CDK7 | 0.47549258 |
105 | BCR | 0.47354541 |
106 | PRKCI | 0.47049848 |
107 | FGFR2 | 0.42855806 |
108 | CSNK1E | 0.42653323 |
109 | MST4 | 0.41772079 |
110 | MAP3K11 | 0.40589220 |
111 | GRK5 | 0.40353490 |
112 | MAP3K4 | 0.39915119 |
113 | TEC | 0.39820516 |
114 | CAMK2A | 0.39013233 |
115 | TNIK | 0.38003353 |
116 | CSNK1G2 | 0.37812160 |
117 | PRKG1 | 0.36699200 |
118 | DYRK1A | 0.36393491 |
119 | CHEK1 | 0.34433232 |
120 | PLK2 | 0.32831807 |
121 | PRKACB | 0.32328523 |
122 | IRAK1 | 0.32294936 |
123 | MINK1 | 0.32027084 |
124 | CAMK1 | 0.31811829 |
125 | ADRBK2 | 0.30807592 |
126 | MAP3K5 | 0.30752632 |
127 | CSNK1A1 | 0.30517930 |
128 | GRK1 | 0.30249151 |
129 | PRKCE | 0.27397936 |
130 | RPS6KB1 | 0.27048240 |
131 | CDK2 | 0.26671057 |
132 | NEK9 | 0.26557362 |
133 | ATM | 0.26480372 |
134 | PRKACA | 0.26189031 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.12376476 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.69892484 |
3 | RNA polymerase_Homo sapiens_hsa03020 | 3.52289530 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.29331459 |
5 | Ribosome_Homo sapiens_hsa03010 | 3.23851268 |
6 | Protein export_Homo sapiens_hsa03060 | 2.86964917 |
7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.57518476 |
8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.49123791 |
9 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.48118501 |
10 | Mismatch repair_Homo sapiens_hsa03430 | 2.22838490 |
11 | DNA replication_Homo sapiens_hsa03030 | 2.22026400 |
12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.21782925 |
13 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.21018570 |
14 | Alzheimers disease_Homo sapiens_hsa05010 | 2.20803849 |
15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.86438141 |
16 | Spliceosome_Homo sapiens_hsa03040 | 1.81618289 |
17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.77743809 |
18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.77190448 |
19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.74202073 |
20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.73053238 |
21 | RNA transport_Homo sapiens_hsa03013 | 1.71966084 |
22 | Homologous recombination_Homo sapiens_hsa03440 | 1.71786883 |
23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.62418769 |
24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.50080556 |
25 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.48756837 |
26 | Purine metabolism_Homo sapiens_hsa00230 | 1.48700461 |
27 | Base excision repair_Homo sapiens_hsa03410 | 1.48402011 |
28 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.45677666 |
29 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.43629056 |
30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.40456418 |
31 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.37504178 |
32 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.36045218 |
33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.33708202 |
34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.29632830 |
35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.26329743 |
36 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.18943439 |
37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.18932518 |
38 | Carbon metabolism_Homo sapiens_hsa01200 | 1.18846718 |
39 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.18375154 |
40 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.11220539 |
41 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.10836840 |
42 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.10248759 |
43 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.08386383 |
44 | RNA degradation_Homo sapiens_hsa03018 | 1.07232990 |
45 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.06378135 |
46 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.06264770 |
47 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.05039052 |
48 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.04240638 |
49 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.03638351 |
50 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.01998749 |
51 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.01161002 |
52 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.99871481 |
53 | Cell cycle_Homo sapiens_hsa04110 | 0.98838727 |
54 | Sulfur relay system_Homo sapiens_hsa04122 | 0.98750703 |
55 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.97076096 |
56 | Nicotine addiction_Homo sapiens_hsa05033 | 0.93908987 |
57 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.92834356 |
58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.91385746 |
59 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.88159906 |
60 | Olfactory transduction_Homo sapiens_hsa04740 | 0.85623455 |
61 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.83603885 |
62 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.83498891 |
63 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.82675644 |
64 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.82051290 |
65 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.79757148 |
66 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.79314370 |
67 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.78990291 |
68 | Peroxisome_Homo sapiens_hsa04146 | 0.77653219 |
69 | Taste transduction_Homo sapiens_hsa04742 | 0.77077591 |
70 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.74569562 |
71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.74179893 |
72 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.73086007 |
73 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.70048064 |
74 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.69614835 |
75 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.66693431 |
76 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.65039577 |
77 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.64831802 |
78 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.64007269 |
79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.63476393 |
80 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.61487703 |
81 | Histidine metabolism_Homo sapiens_hsa00340 | 0.59578249 |
82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.58623678 |
83 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.58081860 |
84 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.57834924 |
85 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.56833046 |
86 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.56090923 |
87 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.53168656 |
88 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.52038721 |
89 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.51947491 |
90 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.49825479 |
91 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.49624681 |
92 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.46223417 |
93 | Circadian rhythm_Homo sapiens_hsa04710 | 0.46160663 |
94 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.45750728 |
95 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.45344216 |
96 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.45238346 |
97 | Morphine addiction_Homo sapiens_hsa05032 | 0.44166700 |
98 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.43662884 |
99 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.40830830 |
100 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.39848217 |
101 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.36622836 |
102 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.35707852 |
103 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.35349517 |
104 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.34861661 |
105 | Galactose metabolism_Homo sapiens_hsa00052 | 0.29576558 |
106 | Phototransduction_Homo sapiens_hsa04744 | 0.29561008 |
107 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.28029299 |
108 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.27948673 |
109 | Insulin secretion_Homo sapiens_hsa04911 | 0.27935986 |
110 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27690560 |
111 | Circadian entrainment_Homo sapiens_hsa04713 | 0.27493763 |
112 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.27478816 |
113 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.25651667 |
114 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.25410242 |
115 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.23139204 |
116 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.23081700 |
117 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.22776406 |
118 | GABAergic synapse_Homo sapiens_hsa04727 | 0.21546120 |
119 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.20669888 |
120 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.20358785 |
121 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.17791255 |
122 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.16030678 |