LIF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.21486272
2skin morphogenesis (GO:0043589)5.18702876
3cell adhesion mediated by integrin (GO:0033627)5.16598894
4response to interleukin-15 (GO:0070672)5.11846241
5regulation of interleukin-12 biosynthetic process (GO:0045075)5.01194654
6positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.79469124
7positive regulation of natural killer cell differentiation (GO:0032825)4.68396066
8regulation of immunoglobulin secretion (GO:0051023)4.58228845
9tolerance induction (GO:0002507)4.56372073
10positive regulation of immunoglobulin mediated immune response (GO:0002891)4.49608882
11positive regulation of B cell mediated immunity (GO:0002714)4.49608882
12regulation of gamma-delta T cell differentiation (GO:0045586)4.46074624
13* tyrosine phosphorylation of STAT protein (GO:0007260)4.43714977
14regulation of vitamin D biosynthetic process (GO:0060556)4.29896494
15regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.28821911
16hypotonic response (GO:0006971)4.28400402
17regulation of transforming growth factor beta1 production (GO:0032908)4.21150081
18regulation of isotype switching to IgG isotypes (GO:0048302)4.20633915
19regulation of interleukin-2 biosynthetic process (GO:0045076)4.19887987
20interferon-gamma production (GO:0032609)4.18343624
21Golgi transport vesicle coating (GO:0048200)4.17719665
22COPI coating of Golgi vesicle (GO:0048205)4.17719665
23positive regulation of humoral immune response (GO:0002922)4.16234637
24positive regulation of gamma-delta T cell activation (GO:0046645)4.14273927
25endodermal cell differentiation (GO:0035987)4.14042846
26negative T cell selection (GO:0043383)4.12534655
27regulation of gamma-delta T cell activation (GO:0046643)4.12532281
28cellular response to interleukin-15 (GO:0071350)4.09925362
29positive regulation of isotype switching (GO:0045830)4.09350333
30substrate-dependent cell migration (GO:0006929)4.06961130
31positive regulation of interleukin-17 production (GO:0032740)4.06334830
32regulation of apoptotic process involved in morphogenesis (GO:1902337)4.04625827
33protein localization to endosome (GO:0036010)4.04116859
34mammary gland epithelial cell proliferation (GO:0033598)4.01875260
35regulation of chronic inflammatory response (GO:0002676)4.00136785
36interferon-gamma secretion (GO:0072643)3.91875286
37negative thymic T cell selection (GO:0045060)3.87327184
38regulation of regulatory T cell differentiation (GO:0045589)3.86600684
39positive regulation of blood vessel endothelial cell migration (GO:0043536)3.84885483
40cellular response to vitamin D (GO:0071305)3.80142360
41JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.74213605
42regulation of cytokine production involved in inflammatory response (GO:1900015)3.71474310
43regulation of membrane protein ectodomain proteolysis (GO:0051043)3.65730596
44positive regulation of activated T cell proliferation (GO:0042104)3.63581829
45positive regulation of interleukin-2 production (GO:0032743)3.63546755
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.58278632
47positive regulation of natural killer cell mediated immunity (GO:0002717)3.56796775
48positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.56796775
49regulation of vitamin metabolic process (GO:0030656)3.47938002
50negative regulation of smooth muscle cell migration (GO:0014912)3.47400749
51positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.46760470
52positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.45928314
53thymic T cell selection (GO:0045061)3.40526959
54regulation of immunoglobulin mediated immune response (GO:0002889)3.40220042
55chondrocyte proliferation (GO:0035988)3.39330799
56positive regulation of immunoglobulin production (GO:0002639)3.36682520
57positive regulation of p38MAPK cascade (GO:1900745)3.34610790
58positive regulation of DNA recombination (GO:0045911)3.34078687
59* positive regulation of astrocyte differentiation (GO:0048711)3.33497960
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30850718
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30850718
62positive regulation of lymphocyte mediated immunity (GO:0002708)3.30633970
63regulation of podosome assembly (GO:0071801)3.29542475
64regulation of B cell mediated immunity (GO:0002712)3.28860184
65positive thymic T cell selection (GO:0045059)3.28690727
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.28326737
67regulation of natural killer cell mediated immunity (GO:0002715)3.28326737
68cellular response to vitamin (GO:0071295)3.26833021
69NIK/NF-kappaB signaling (GO:0038061)3.26412129
70positive regulation of extracellular matrix organization (GO:1903055)3.25063179
71positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.25030502
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23740940
73myeloid dendritic cell differentiation (GO:0043011)3.20304774
74CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.20169414
75stress fiber assembly (GO:0043149)3.18829618
76T cell selection (GO:0045058)3.18057844
77T cell apoptotic process (GO:0070231)3.17130853
78hemidesmosome assembly (GO:0031581)3.15721884
79* decidualization (GO:0046697)3.15297749
80cell-substrate junction assembly (GO:0007044)3.14803839
81regulation of alpha-beta T cell proliferation (GO:0046640)3.13954903
82regulation of interleukin-2 production (GO:0032663)3.13116326
83negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.12818812
84negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12798712
85positive T cell selection (GO:0043368)3.12658504
86regulation of natural killer cell differentiation (GO:0032823)3.12370850
87regulation of immunoglobulin production (GO:0002637)3.09500577
88positive regulation of T cell cytokine production (GO:0002726)3.07923862
89response to vitamin D (GO:0033280)3.07652326
90regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.05325350
91positive regulation of macrophage activation (GO:0043032)3.04237167
92regulation of extracellular matrix disassembly (GO:0010715)3.03979667
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02969497
94branching involved in mammary gland duct morphogenesis (GO:0060444)3.02354686
95actin filament depolymerization (GO:0030042)3.01458063
96regulation of metalloenzyme activity (GO:0048552)3.01343594
97pinocytosis (GO:0006907)3.00745062
98epithelial cell-cell adhesion (GO:0090136)2.96954728
99regulation of memory T cell differentiation (GO:0043380)2.95522606
100positive regulation of cell killing (GO:0031343)2.95411733
101regulation of T-helper 1 type immune response (GO:0002825)2.95406870
102regulation of isotype switching (GO:0045191)2.94675267
103positive regulation of leukocyte mediated immunity (GO:0002705)2.93375822
104positive regulation of osteoblast proliferation (GO:0033690)2.93032762
105regulation of thymocyte apoptotic process (GO:0070243)2.92505168
106positive regulation of cytokine biosynthetic process (GO:0042108)2.92013021
107cell migration involved in sprouting angiogenesis (GO:0002042)2.91611232
108regulation of activated T cell proliferation (GO:0046006)2.90976800
109regulation of leukocyte mediated cytotoxicity (GO:0001910)2.89277510
110positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88610071
111regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.88380950
112negative regulation of interleukin-12 production (GO:0032695)2.87229677
113atrioventricular valve morphogenesis (GO:0003181)2.87151385
114leukocyte aggregation (GO:0070486)2.83811844
115regulation of fever generation (GO:0031620)2.83264571
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83019352
117regulation of transforming growth factor beta production (GO:0071634)2.82396273
118growth hormone receptor signaling pathway (GO:0060396)2.82349099
119regulation of T-helper cell differentiation (GO:0045622)2.82218836
120lymphocyte apoptotic process (GO:0070227)2.82002818
121hepatocyte apoptotic process (GO:0097284)2.81169868
122positive regulation of cell fate commitment (GO:0010455)2.80421216
123regulation of inflammatory response to antigenic stimulus (GO:0002861)2.79593197
124mesodermal cell differentiation (GO:0048333)2.75496938
125wound healing, spreading of epidermal cells (GO:0035313)2.74331635
126glial cell migration (GO:0008347)2.74128540
127hyaluronan catabolic process (GO:0030214)2.73467884
128myeloid dendritic cell activation (GO:0001773)2.72924104
129regulation of cell killing (GO:0031341)2.72406763
130muscle cell migration (GO:0014812)2.71759732
131regulation of lymphocyte mediated immunity (GO:0002706)2.71693436
132response to protozoan (GO:0001562)2.71687300
133positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70416846
134negative regulation of fatty acid transport (GO:2000192)2.69523447
135regulation of hypersensitivity (GO:0002883)2.68952573
136endothelial cell chemotaxis (GO:0035767)2.68899729
137activation of MAPKKK activity (GO:0000185)2.68375229
138T cell costimulation (GO:0031295)2.68324042
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68292066
140protein hydroxylation (GO:0018126)2.67792348
141positive regulation of heat generation (GO:0031652)2.67671175
142positive regulation of T-helper 1 type immune response (GO:0002827)2.66564685
143vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66194165
144modulation by symbiont of host cellular process (GO:0044068)2.66075189
145positive regulation of B cell proliferation (GO:0030890)2.65862550
146adherens junction assembly (GO:0034333)2.65528081
147membrane raft organization (GO:0031579)2.64386019
148T cell migration (GO:0072678)2.64304558
149lymphocyte costimulation (GO:0031294)2.64225980
150antigen processing and presentation of endogenous antigen (GO:0019883)2.63836684
151endocytic recycling (GO:0032456)2.62022614
152response to hepatocyte growth factor (GO:0035728)2.61238782
153cellular response to hepatocyte growth factor stimulus (GO:0035729)2.61238782
154barbed-end actin filament capping (GO:0051016)2.59299693
155positive regulation of odontogenesis (GO:0042482)2.58560672
156regulation of response to osmotic stress (GO:0047484)2.57836941
157regulation of smooth muscle cell migration (GO:0014910)2.57330064
158endoplasmic reticulum unfolded protein response (GO:0030968)2.56265241
159wound healing, spreading of cells (GO:0044319)2.55957945
160activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55889421
161protein heterotrimerization (GO:0070208)2.55301385
162membrane protein ectodomain proteolysis (GO:0006509)2.55241947
163positive regulation of keratinocyte differentiation (GO:0045618)2.54639858
164regulation of extracellular matrix organization (GO:1903053)2.53319022
165dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52760670
166regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.52328159
167collagen metabolic process (GO:0032963)2.50375321
168focal adhesion assembly (GO:0048041)2.50132400
169cell-substrate adherens junction assembly (GO:0007045)2.50132400
170collagen catabolic process (GO:0030574)2.48452398
171* regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.47892730
172branching involved in salivary gland morphogenesis (GO:0060445)2.47548930
173planar cell polarity pathway involved in neural tube closure (GO:0090179)2.47359141
174peptidyl-proline hydroxylation (GO:0019511)2.47137841
175positive regulation of nuclease activity (GO:0032075)2.46807831
176protein retention in ER lumen (GO:0006621)2.46283250
177negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.44751906
178regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44128553
179extracellular matrix disassembly (GO:0022617)2.43191628
180* lung vasculature development (GO:0060426)2.42180654
181regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.41174920
182fibrinolysis (GO:0042730)2.40812813
183apoptotic cell clearance (GO:0043277)2.40805871
184cellular response to nutrient (GO:0031670)2.39225250
185cellular response to unfolded protein (GO:0034620)2.38866406
186ER-nucleus signaling pathway (GO:0006984)2.38615919
187positive regulation of endothelial cell apoptotic process (GO:2000353)2.37372414
188activation of Rac GTPase activity (GO:0032863)2.36647158
189regulation of type I interferon-mediated signaling pathway (GO:0060338)2.36560139
190regulation of T-helper 2 cell differentiation (GO:0045628)2.33695433
191hyaluronan metabolic process (GO:0030212)2.33191152
192type B pancreatic cell proliferation (GO:0044342)2.31450979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.14625900
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.54691609
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.04603784
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.81358653
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.64131862
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.55009899
7E2F7_22180533_ChIP-Seq_HELA_Human4.10955153
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.35704983
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.02953147
10MYC_22102868_ChIP-Seq_BL_Human2.92782048
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87008129
12* RUNX_20019798_ChIP-Seq_JUKART_Human2.41386176
13MYB_26560356_Chip-Seq_TH2_Human2.37967142
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.33409603
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24263450
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20267347
17* MAF_26560356_Chip-Seq_TH1_Human2.18977140
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.11177723
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.08503897
20TCF7_22412390_ChIP-Seq_EML_Mouse2.08055706
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07863501
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03845713
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.98990572
24MYB_26560356_Chip-Seq_TH1_Human1.95002467
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92002375
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86854505
27VDR_21846776_ChIP-Seq_THP-1_Human1.86413471
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79367324
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.78760011
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78181871
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78000541
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75146837
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74092177
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.72866255
35KDM2B_26808549_Chip-Seq_DND41_Human1.71755571
36* LXR_22292898_ChIP-Seq_THP-1_Human1.70931898
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.70921858
38UTX_26944678_Chip-Seq_JUKART_Human1.68263978
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.67283974
40* TP53_22127205_ChIP-Seq_IMR90_Human1.67228076
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61469879
42* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60006624
43VDR_24763502_ChIP-Seq_THP-1_Human1.57500142
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53659184
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53389305
46* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52189832
47* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52189832
48* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52132426
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51692334
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.47914424
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47863353
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46579988
53CLOCK_20551151_ChIP-Seq_293T_Human1.44105043
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43787897
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.43643067
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41735688
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41267416
58* MAF_26560356_Chip-Seq_TH2_Human1.39270842
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.37991488
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37988432
61ATF3_27146783_Chip-Seq_COLON_Human1.34462447
62* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32511259
63GATA3_27048872_Chip-Seq_THYMUS_Human1.32471914
64SCL_19346495_ChIP-Seq_HPC-7_Human1.32132597
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.29203366
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26885242
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26532886
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.25272489
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.25067911
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23953097
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.23765925
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21377938
73* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20854135
74* KDM2B_26808549_Chip-Seq_K562_Human1.19882515
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19516907
76* CJUN_26792858_Chip-Seq_BT549_Human1.19468824
77* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14833078
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14168555
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13753618
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13234077
81* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12479681
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11747326
83RACK7_27058665_Chip-Seq_MCF-7_Human1.11229942
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.09525683
85NCOR1_26117541_ChIP-Seq_K562_Human1.07978782
86* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07812874
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07455210
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.07254394
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07001609
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05388087
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04702687
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04514340
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03426358
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01696750
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01674498
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00862846
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00567218
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00471535
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00098021
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99889961
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97983424
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97889806
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97624057
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97407473
105* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97136177
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96504599
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95667081
108KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95227563
109VDR_24787735_ChIP-Seq_THP-1_Human0.95015116
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.94552086
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.94552086
112GATA6_25053715_ChIP-Seq_YYC3_Human0.93885875
113PU_27001747_Chip-Seq_BMDM_Mouse0.93147131
114* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92909945
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92487688
116SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92056603
117SOX2_20726797_ChIP-Seq_SW620_Human0.92034105
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91506558
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91388470
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90782362
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90638913
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90510659
123BRD4_25478319_ChIP-Seq_HGPS_Human0.90271566
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.89748723
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89433785
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88984231
127* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87680095
128EGR1_19032775_ChIP-ChIP_M12_Human0.86077277
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85965089
130E2F4_17652178_ChIP-ChIP_JURKAT_Human0.83547574
131AR_21909140_ChIP-Seq_LNCAP_Human0.81331629
132SPI1_23547873_ChIP-Seq_NB4_Human0.80286366
133TP63_19390658_ChIP-ChIP_HaCaT_Human0.79459944
134ZNF263_19887448_ChIP-Seq_K562_Human0.79170792
135* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78340186
136JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77080809
137MYC_19079543_ChIP-ChIP_MESCs_Mouse0.76724860
138IRF8_21731497_ChIP-ChIP_J774_Mouse0.76567827
139SPI1_23127762_ChIP-Seq_K562_Human0.76380905
140TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75995072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer4.12560110
2MP0003436_decreased_susceptibility_to3.99230755
3MP0010352_gastrointestinal_tract_polyps3.27541583
4MP0000685_abnormal_immune_system3.06339297
5MP0003763_abnormal_thymus_physiology3.02905484
6MP0009840_abnormal_foam_cell3.00335691
7MP0005387_immune_system_phenotype2.80783024
8MP0001790_abnormal_immune_system2.80783024
9MP0003303_peritoneal_inflammation2.80091868
10MP0005671_abnormal_response_to2.53698259
11MP0001853_heart_inflammation2.53262856
12MP0002933_joint_inflammation2.44779145
13MP0002405_respiratory_system_inflammati2.43942417
14MP0009333_abnormal_splenocyte_physiolog2.43275858
15MP0005000_abnormal_immune_tolerance2.40525240
16MP0004510_myositis2.37167321
17MP0004272_abnormal_basement_membrane2.35752027
18MP0010155_abnormal_intestine_physiology2.34632215
19MP0001800_abnormal_humoral_immune2.28494679
20MP0005076_abnormal_cell_differentiation2.28375166
21MP0004947_skin_inflammation2.06983266
22MP0005451_abnormal_body_composition1.99361345
23* MP0009785_altered_susceptibility_to1.99054837
24MP0005023_abnormal_wound_healing1.97007157
25* MP0003866_abnormal_defecation1.94636424
26* MP0002723_abnormal_immune_serum1.90562279
27MP0001835_abnormal_antigen_presentation1.86968254
28MP0003566_abnormal_cell_adhesion1.86863314
29MP0002396_abnormal_hematopoietic_system1.86487990
30MP0001533_abnormal_skeleton_physiology1.80993083
31* MP0002452_abnormal_antigen_presenting1.80773674
32MP0002148_abnormal_hypersensitivity_rea1.74207238
33* MP0002398_abnormal_bone_marrow1.72792477
34* MP0002420_abnormal_adaptive_immunity1.72320734
35* MP0005025_abnormal_response_to1.71351846
36* MP0001819_abnormal_immune_cell1.69519026
37MP0003045_fibrosis1.68010843
38MP0005257_abnormal_intraocular_pressure1.64997183
39MP0001849_ear_inflammation1.60746278
40MP0000703_abnormal_thymus_morphology1.60665186
41MP0000465_gastrointestinal_hemorrhage1.59474902
42* MP0004808_abnormal_hematopoietic_stem1.58733631
43MP0003448_altered_tumor_morphology1.54064586
44MP0003705_abnormal_hypodermis_morpholog1.53697675
45MP0002166_altered_tumor_susceptibility1.51492755
46MP0003091_abnormal_cell_migration1.50841961
47MP0006082_CNS_inflammation1.50220537
48MP0002006_tumorigenesis1.48630881
49MP0005623_abnormal_meninges_morphology1.48566556
50MP0005164_abnormal_response_to1.47585887
51MP0000858_altered_metastatic_potential1.46817978
52MP0002722_abnormal_immune_system1.46521060
53MP0000490_abnormal_crypts_of1.44591465
54MP0001873_stomach_inflammation1.44534982
55* MP0000716_abnormal_immune_system1.44165008
56MP0001348_abnormal_lacrimal_gland1.43956263
57MP0005275_abnormal_skin_tensile1.42517763
58MP0000689_abnormal_spleen_morphology1.41390909
59MP0003453_abnormal_keratinocyte_physiol1.41269020
60MP0003950_abnormal_plasma_membrane1.39714922
61* MP0001845_abnormal_inflammatory_respons1.35344842
62MP0005310_abnormal_salivary_gland1.32804288
63MP0001542_abnormal_bone_strength1.32556418
64MP0004233_abnormal_muscle_weight1.30795600
65* MP0002419_abnormal_innate_immunity1.30122923
66MP0002877_abnormal_melanocyte_morpholog1.27363731
67MP0010368_abnormal_lymphatic_system1.26913446
68MP0009278_abnormal_bone_marrow1.25867418
69MP0005058_abnormal_lysosome_morphology1.22594726
70MP0000750_abnormal_muscle_regeneration1.21066871
71* MP0002429_abnormal_blood_cell1.20899319
72MP0000767_abnormal_smooth_muscle1.20621304
73MP0003724_increased_susceptibility_to1.20534284
74MP0010234_abnormal_vibrissa_follicle1.19400662
75MP0004858_abnormal_nervous_system1.18920809
76MP0000751_myopathy1.15298564
77MP0002796_impaired_skin_barrier1.14863769
78MP0002089_abnormal_postnatal_growth/wei1.13577280
79MP0002896_abnormal_bone_mineralization1.13275376
80MP0000003_abnormal_adipose_tissue1.10037460
81* MP0001881_abnormal_mammary_gland1.09824237
82* MP0005166_decreased_susceptibility_to1.08294628
83* MP0000627_abnormal_mammary_gland1.08057880
84MP0003279_aneurysm1.07374972
85* MP0005390_skeleton_phenotype1.06001038
86MP0010307_abnormal_tumor_latency1.01779691
87MP0009764_decreased_sensitivity_to1.01205616
88MP0005464_abnormal_platelet_physiology0.98985953
89MP0001216_abnormal_epidermal_layer0.98755682
90* MP0002998_abnormal_bone_remodeling0.98290287
91MP0001545_abnormal_hematopoietic_system0.97757178
92MP0005397_hematopoietic_system_phenotyp0.97757178
93MP0000733_abnormal_muscle_development0.96836508
94MP0003795_abnormal_bone_structure0.95449997
95MP0005621_abnormal_cell_physiology0.93920387
96MP0005501_abnormal_skin_physiology0.90722790
97MP0005165_increased_susceptibility_to0.90530679
98MP0005375_adipose_tissue_phenotype0.90177640
99MP0000604_amyloidosis0.90132586
100MP0000477_abnormal_intestine_morphology0.85037234
101* MP0005508_abnormal_skeleton_morphology0.83699464
102MP0002254_reproductive_system_inflammat0.83415761
103MP0002019_abnormal_tumor_incidence0.83294715
104MP0001851_eye_inflammation0.82658972
105MP0005409_darkened_coat_color0.82083755
106MP0008438_abnormal_cutaneous_collagen0.81693822
107MP0009053_abnormal_anal_canal0.78651834
108MP0009780_abnormal_chondrocyte_physiolo0.78448054
109MP0005197_abnormal_uvea_morphology0.77670218
110MP0003191_abnormal_cellular_cholesterol0.77656877
111MP0008007_abnormal_cellular_replicative0.76678467
112MP0009384_cardiac_valve_regurgitation0.75232016
113MP0002295_abnormal_pulmonary_circulatio0.74729656
114MP0002086_abnormal_extraembryonic_tissu0.74425681
115MP0002060_abnormal_skin_morphology0.74267562
116MP0003075_altered_response_to0.73534144
117MP0000350_abnormal_cell_proliferation0.73489428
118* MP0001614_abnormal_blood_vessel0.73062057
119MP0000759_abnormal_skeletal_muscle0.72740539
120MP0002138_abnormal_hepatobiliary_system0.72670065
121MP0008004_abnormal_stomach_pH0.72002923
122MP0010771_integument_phenotype0.71569963
123MP0008057_abnormal_DNA_replication0.71498399
124MP0000013_abnormal_adipose_tissue0.70072555
125MP0005666_abnormal_adipose_tissue0.68146767
126MP0000343_altered_response_to0.68069588
127MP0004185_abnormal_adipocyte_glucose0.67731191
128MP0000537_abnormal_urethra_morphology0.67094760
129MP0001958_emphysema0.66382462
130MP0001915_intracranial_hemorrhage0.66165257
131MP0002168_other_aberrant_phenotype0.64421680
132* MP0008469_abnormal_protein_level0.63848872
133MP0001243_abnormal_dermal_layer0.63790181
134MP0002088_abnormal_embryonic_growth/wei0.63201061
135* MP0000249_abnormal_blood_vessel0.62147506
136MP0003984_embryonic_growth_retardation0.60723128
137MP0004782_abnormal_surfactant_physiolog0.60368349
138MP0001191_abnormal_skin_condition0.58693183
139MP0004197_abnormal_fetal_growth/weight/0.58600421
140* MP0002925_abnormal_cardiovascular_devel0.58145864
141MP0003077_abnormal_cell_cycle0.58058163

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)5.16056837
2Stomatitis (HP:0010280)4.57626678
3T lymphocytopenia (HP:0005403)4.03790465
4Persistence of primary teeth (HP:0006335)4.02694040
5Abnormality of T cell number (HP:0011839)4.00775975
6Chronic diarrhea (HP:0002028)3.97790408
7IgA deficiency (HP:0002720)3.91865638
8Ankle contracture (HP:0006466)3.88387965
9Recurrent fungal infections (HP:0002841)3.85121858
10Myositis (HP:0100614)3.83531219
11Achilles tendon contracture (HP:0001771)3.78149298
12Elevated erythrocyte sedimentation rate (HP:0003565)3.74670074
13Vertebral compression fractures (HP:0002953)3.69943770
14Retrobulbar optic neuritis (HP:0100654)3.65367215
15Optic neuritis (HP:0100653)3.65367215
16Arterial tortuosity (HP:0005116)3.61591187
17Orchitis (HP:0100796)3.46311211
18Spondylolisthesis (HP:0003302)3.36680074
19Abnormality of the Achilles tendon (HP:0005109)3.36270957
20Follicular hyperkeratosis (HP:0007502)3.34004282
21Vascular tortuosity (HP:0004948)3.30103421
22Abnormality of T cells (HP:0002843)3.28266335
23Cheilitis (HP:0100825)3.23578857
24Spinal rigidity (HP:0003306)3.11152189
25Peritonitis (HP:0002586)3.07901884
26Arterial thrombosis (HP:0004420)3.03712914
27Upper limb amyotrophy (HP:0009129)2.99695626
28Distal upper limb amyotrophy (HP:0007149)2.99695626
29Pulmonary infiltrates (HP:0002113)2.90428656
30Short nail (HP:0001799)2.86806652
31Interstitial pulmonary disease (HP:0006530)2.85180248
32Abnormal platelet volume (HP:0011876)2.83424438
33Hyperacusis (HP:0010780)2.82816267
34Increased mean platelet volume (HP:0011877)2.82604688
35Eczematoid dermatitis (HP:0000976)2.82084180
36Recurrent viral infections (HP:0004429)2.81380715
37Obstructive sleep apnea (HP:0002870)2.81349297
38Mildly elevated creatine phosphokinase (HP:0008180)2.80635367
39Recurrent cutaneous fungal infections (HP:0011370)2.76255055
40Chronic mucocutaneous candidiasis (HP:0002728)2.76255055
41Fragile skin (HP:0001030)2.73696660
42Thin bony cortex (HP:0002753)2.70089442
43Atrophic scars (HP:0001075)2.68942424
44Nasal polyposis (HP:0100582)2.64788124
45Type 1 muscle fiber predominance (HP:0003803)2.62998734
46Abnormality of T cell physiology (HP:0011840)2.61258080
47Elbow flexion contracture (HP:0002987)2.59014104
48Wormian bones (HP:0002645)2.58038708
49Protrusio acetabuli (HP:0003179)2.56664195
50Ulnar bowing (HP:0003031)2.54017234
51Bladder diverticulum (HP:0000015)2.53416988
52Myocardial infarction (HP:0001658)2.52622277
53Slender build (HP:0001533)2.51906768
54Increased variability in muscle fiber diameter (HP:0003557)2.50810929
55Increased IgM level (HP:0003496)2.50792492
56Hemoptysis (HP:0002105)2.50082350
57Aortic regurgitation (HP:0001659)2.49379253
58Distal lower limb muscle weakness (HP:0009053)2.48393890
59Aortic aneurysm (HP:0004942)2.48273220
60IgM deficiency (HP:0002850)2.46643215
61Thrombocytosis (HP:0001894)2.46282193
62Premature rupture of membranes (HP:0001788)2.45144029
63Joint swelling (HP:0001386)2.42781670
64Panhypogammaglobulinemia (HP:0003139)2.42444633
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.41931680
66Abnormality of the nasal septum (HP:0000419)2.39113433
67Increased connective tissue (HP:0009025)2.37532562
68Mitral regurgitation (HP:0001653)2.37308068
69Pustule (HP:0200039)2.34138943
70Chronic otitis media (HP:0000389)2.34009780
71Blue sclerae (HP:0000592)2.32257397
72Inflammation of the large intestine (HP:0002037)2.32102252
73Aortic dissection (HP:0002647)2.30435592
74Shallow orbits (HP:0000586)2.30415220
75Broad face (HP:0000283)2.29683096
76Gastrointestinal infarctions (HP:0005244)2.29370125
77Abnormality of skeletal muscle fiber size (HP:0012084)2.29007861
78Generalized amyotrophy (HP:0003700)2.28183868
79Abnormality of the distal phalanges of the toes (HP:0010182)2.27038306
80Gastrointestinal inflammation (HP:0004386)2.26806358
81Cerebral aneurysm (HP:0004944)2.25987597
82Abnormality of the peritoneum (HP:0002585)2.25392291
83Recurrent bronchitis (HP:0002837)2.24864418
84Abnormality of dentin (HP:0010299)2.23767423
85Gingival bleeding (HP:0000225)2.22524914
86Deep venous thrombosis (HP:0002625)2.22359565
87Fatigue (HP:0012378)2.22325870
88Vasculitis (HP:0002633)2.21491664
89Lower limb amyotrophy (HP:0007210)2.18879958
90Milia (HP:0001056)2.17668870
91Keratoconjunctivitis sicca (HP:0001097)2.15169166
92Menorrhagia (HP:0000132)2.13152523
93Abnormality of the fingertips (HP:0001211)2.12845357
94Hand muscle atrophy (HP:0009130)2.12499933
95Dilatation of the ascending aorta (HP:0005111)2.11881510
96Mitral stenosis (HP:0001718)2.11862964
97Ankyloglossia (HP:0010296)2.11507105
98Overgrowth (HP:0001548)2.10234954
99Osteolytic defects of the phalanges of the hand (HP:0009771)2.10128358
100Osteolytic defects of the hand bones (HP:0009699)2.10128358
101Broad metatarsal (HP:0001783)2.10127790
102Esophageal varix (HP:0002040)2.08951233
103Disproportionate tall stature (HP:0001519)2.08381590
104Abnormality of the nasal mucosa (HP:0000433)2.08102748
105Acute myeloid leukemia (HP:0004808)2.07958117
106Aneurysm (HP:0002617)2.06410114
107Mitral valve prolapse (HP:0001634)2.05825873
108Long toe (HP:0010511)2.04280943
109Severe combined immunodeficiency (HP:0004430)2.03287368
110IgG deficiency (HP:0004315)2.01640237
111Chest pain (HP:0100749)2.00342912
112Natal tooth (HP:0000695)1.97906826
113Mediastinal lymphadenopathy (HP:0100721)1.97680957
114Spinal cord lesions (HP:0100561)1.96633043
115Syringomyelia (HP:0003396)1.96633043
116Hypoventilation (HP:0002791)1.95704651
117Cervical subluxation (HP:0003308)1.95030573
118Protruding ear (HP:0000411)1.95017963
119Axonal loss (HP:0003447)1.94748314
120Soft skin (HP:0000977)1.94608171
121Nuclear cataract (HP:0100018)1.94123819
122Somatic mutation (HP:0001428)1.93702428
123B lymphocytopenia (HP:0010976)1.93305200
124Abnormality of B cell number (HP:0010975)1.93305200
125Difficulty climbing stairs (HP:0003551)1.92704351
126Leukocytosis (HP:0001974)1.92160975
127Long palpebral fissure (HP:0000637)1.91819490
128Biconcave vertebral bodies (HP:0004586)1.91354877
129Keratoconjunctivitis (HP:0001096)1.91063410
130Insomnia (HP:0100785)1.90480517
131Joint laxity (HP:0001388)1.89591589
132Subacute progressive viral hepatitis (HP:0006572)1.89238202
133Coxa vara (HP:0002812)1.86897396
134Bronchomalacia (HP:0002780)1.85829810
135Distal lower limb amyotrophy (HP:0008944)1.84774960
136Tibial bowing (HP:0002982)1.83870690
137Renal duplication (HP:0000075)1.83217036
138Combined immunodeficiency (HP:0005387)1.81662697
139Abnormality of liposaccharide metabolism (HP:0010968)1.80885085
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.80885085
141Abnormality of glycolipid metabolism (HP:0010969)1.80885085
142Ureteral stenosis (HP:0000071)1.80632143
143Joint stiffness (HP:0001387)1.80441237
144Dislocated radial head (HP:0003083)1.80335215
145Congenital glaucoma (HP:0001087)1.79698294
146Flat acetabular roof (HP:0003180)1.79576171
147Genu recurvatum (HP:0002816)1.79156580
148Deep palmar crease (HP:0006191)1.79144746
149Abnormal platelet function (HP:0011869)1.76682086
150Impaired platelet aggregation (HP:0003540)1.76682086
151Abnormality of oral frenula (HP:0000190)1.76068276
152Selective tooth agenesis (HP:0001592)1.75665124
153Adactyly (HP:0009776)1.75439581
154Anorexia (HP:0002039)1.74576684
155Emphysema (HP:0002097)1.74469281
156Entropion (HP:0000621)1.74322095
157Hyperparathyroidism (HP:0000843)1.73188515
158Glomerulopathy (HP:0100820)1.72033306
159Thoracolumbar scoliosis (HP:0002944)1.72000064
160Acrocyanosis (HP:0001063)1.71969270
161Deviation of the thumb (HP:0009603)1.71612276
162Eosinophilia (HP:0001880)1.71205364
163Tetraparesis (HP:0002273)1.70546503
164Femoral bowing (HP:0002980)1.69807503
165Arthralgia (HP:0002829)1.69259902
166Abnormality of the acetabulum (HP:0003170)1.69228200
167Abnormality of the radial head (HP:0003995)1.69210854
168Abnormal ossification of hand bones (HP:0005921)1.69028934
169Arnold-Chiari malformation (HP:0002308)1.68935587
170Bone pain (HP:0002653)1.68713075
171Lymphoma (HP:0002665)1.68574715
172Abnormality of the pericardium (HP:0001697)1.68214898
173Hypergammaglobulinemia (HP:0010702)1.67030190
174Dysostosis multiplex (HP:0000943)1.66857305
175Upper limb muscle weakness (HP:0003484)1.65566691
176Ureteral obstruction (HP:0006000)1.65490146
177Radial bowing (HP:0002986)1.65323637
178Bowed forearm bones (HP:0003956)1.64804507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.15487391
2EPHA24.34869768
3MAP4K14.17141318
4JAK33.43558996
5LMTK22.94172044
6EEF2K2.87768375
7MST1R2.86148375
8MAP3K142.58970430
9ZAP702.49192774
10PIM22.34742199
11CDK122.33430489
12PRPF4B2.33150745
13ITK2.31946743
14EPHA32.11221919
15TRIB32.06074381
16EPHB12.04642824
17FGFR42.03049100
18LATS22.01060410
19STK101.94904552
20NTRK11.92714172
21MET1.89550986
22MAP3K131.78257888
23CHUK1.67897583
24ERBB41.63533688
25PKN21.56470259
26IKBKB1.56187856
27RPS6KA41.55217547
28TESK11.51617515
29ICK1.50303862
30TEC1.46796612
31FGFR31.45206583
32TBK11.41167287
33BMX1.36287063
34TYK21.34226287
35MYLK1.32903796
36SMG11.30397802
37MAP3K31.28968118
38JAK11.25860237
39TAOK11.25684793
40MOS1.24432332
41ALK1.22085654
42HCK1.21408714
43PIM11.19765678
44TTN1.17277760
45IKBKE1.12562145
46NLK1.11880001
47MAP3K71.11729963
48CSK1.09994990
49PTK61.09096349
50CDK61.09080177
51FLT31.08932371
52LCK1.08888713
53TSSK61.07973469
54LRRK21.05818887
55LIMK11.04552234
56SIK11.02139742
57PAK21.01422576
58ARAF0.99284394
59MST40.98682522
60EPHB20.98613746
61CDK80.98538019
62FGFR10.97323237
63STK380.97115099
64CDC42BPA0.96975617
65MAP3K100.95672389
66PRKD20.95268201
67MAP3K110.95173973
68MAP3K90.91659993
69LATS10.90531346
70BTK0.87436259
71TAOK20.87342004
72RPS6KA20.85245319
73NEK90.83928259
74SIK20.83016018
75DMPK0.81181264
76NME20.80077859
77PDGFRB0.79109128
78RPS6KB20.79061805
79JAK20.78127291
80MAP2K30.78082555
81TRPM70.75364311
82CDK40.74299746
83PDGFRA0.74291843
84MAP3K80.73501343
85STK30.71856544
86MTOR0.70545050
87BRD40.65538440
88MAPKAPK20.65301172
89RPS6KA50.64383037
90PTK20.63691607
91ABL20.62364965
92GRK60.61912061
93RPS6KC10.60146209
94RPS6KL10.60146209
95ILK0.59050115
96SIK30.58376929
97MELK0.57463067
98CDK90.57441535
99KIT0.56807859
100TGFBR20.54262270
101CLK10.53751601
102SYK0.51925983
103EGFR0.51194837
104ERN10.50493178
105PAK10.48953696
106TYRO30.48049980
107PRKG20.47835295
108IRAK30.47599145
109GSK3A0.47284242
110PRKCH0.46397391
111PAK40.44226189
112MAPK110.43843126
113MARK30.43787514
114INSR0.43197329
115TGFBR10.42759342
116HIPK20.41988246
117TESK20.41312376
118MAP3K120.41059635
119DDR20.40636477
120PRKCQ0.40579954
121RPS6KA60.40336867
122DAPK30.39908117
123RPS6KA10.39828414
124MAP3K60.39238970
125NEK20.38781678
126MAP3K10.38677020
127RIPK10.37575324
128ROCK10.37066736
129MAP3K50.35476063
130CDC70.35095215
131CDK70.34669537
132STK240.32518195
133MAPK40.32503285
134RAF10.32451964
135FER0.31795262
136MAPK10.31673205
137ROCK20.31542325
138ABL10.30967135
139LYN0.30196126
140KSR20.25144981
141IRAK10.23334879

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.90538807
2Asthma_Homo sapiens_hsa053103.73841191
3Allograft rejection_Homo sapiens_hsa053303.52948626
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.92713891
5Autoimmune thyroid disease_Homo sapiens_hsa053202.63899582
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.48748488
7T cell receptor signaling pathway_Homo sapiens_hsa046602.43342710
8Type I diabetes mellitus_Homo sapiens_hsa049402.37718454
9Graft-versus-host disease_Homo sapiens_hsa053322.31005969
10* Jak-STAT signaling pathway_Homo sapiens_hsa046302.21806920
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.12084643
12Hematopoietic cell lineage_Homo sapiens_hsa046402.08620451
13Measles_Homo sapiens_hsa051622.07662599
14Primary immunodeficiency_Homo sapiens_hsa053401.97570585
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89194817
16Leishmaniasis_Homo sapiens_hsa051401.81064965
17* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.78756712
18Toxoplasmosis_Homo sapiens_hsa051451.71164793
19Osteoclast differentiation_Homo sapiens_hsa043801.70385065
20* TNF signaling pathway_Homo sapiens_hsa046681.70189308
21Other glycan degradation_Homo sapiens_hsa005111.68681349
22Small cell lung cancer_Homo sapiens_hsa052221.65121779
23Chronic myeloid leukemia_Homo sapiens_hsa052201.52972413
24Malaria_Homo sapiens_hsa051441.49296290
25Viral myocarditis_Homo sapiens_hsa054161.46499029
26Prion diseases_Homo sapiens_hsa050201.46394757
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44497646
28Acute myeloid leukemia_Homo sapiens_hsa052211.36051633
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35886675
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32677850
31Hepatitis B_Homo sapiens_hsa051611.30827531
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.29942182
33HTLV-I infection_Homo sapiens_hsa051661.29892548
34Legionellosis_Homo sapiens_hsa051341.26243874
35Prolactin signaling pathway_Homo sapiens_hsa049171.24119640
36MicroRNAs in cancer_Homo sapiens_hsa052061.21494458
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16477769
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15863521
39Apoptosis_Homo sapiens_hsa042101.15178313
40Viral carcinogenesis_Homo sapiens_hsa052031.14831338
41Herpes simplex infection_Homo sapiens_hsa051681.14645164
42Antigen processing and presentation_Homo sapiens_hsa046121.12841118
43p53 signaling pathway_Homo sapiens_hsa041151.12230395
44Shigellosis_Homo sapiens_hsa051311.11849721
45Rheumatoid arthritis_Homo sapiens_hsa053231.11786633
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11107277
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05773872
48Galactose metabolism_Homo sapiens_hsa000521.04617526
49Pancreatic cancer_Homo sapiens_hsa052121.03758900
50B cell receptor signaling pathway_Homo sapiens_hsa046621.02762084
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00946536
52ECM-receptor interaction_Homo sapiens_hsa045121.00810471
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00298989
54Proteoglycans in cancer_Homo sapiens_hsa052050.99909036
55Glioma_Homo sapiens_hsa052140.98586852
56Influenza A_Homo sapiens_hsa051640.96951512
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96166378
58HIF-1 signaling pathway_Homo sapiens_hsa040660.95610712
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94644285
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.94334701
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89745553
62Bladder cancer_Homo sapiens_hsa052190.89401701
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89265228
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88743129
65Amoebiasis_Homo sapiens_hsa051460.87535066
66Dilated cardiomyopathy_Homo sapiens_hsa054140.87177827
67Chemokine signaling pathway_Homo sapiens_hsa040620.86769200
68Focal adhesion_Homo sapiens_hsa045100.85269389
69Salmonella infection_Homo sapiens_hsa051320.83223021
70Fructose and mannose metabolism_Homo sapiens_hsa000510.82904688
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82900603
72Renal cell carcinoma_Homo sapiens_hsa052110.80201621
73Epstein-Barr virus infection_Homo sapiens_hsa051690.79077897
74Lysosome_Homo sapiens_hsa041420.76121838
75VEGF signaling pathway_Homo sapiens_hsa043700.75585255
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73992972
77Hepatitis C_Homo sapiens_hsa051600.73013547
78Tuberculosis_Homo sapiens_hsa051520.72732011
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71869863
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71599059
81Vibrio cholerae infection_Homo sapiens_hsa051100.70536693
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69189238
83Protein digestion and absorption_Homo sapiens_hsa049740.68737048
84Pertussis_Homo sapiens_hsa051330.68558416
85Adherens junction_Homo sapiens_hsa045200.67631512
86MAPK signaling pathway_Homo sapiens_hsa040100.67089877
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.66283626
88Colorectal cancer_Homo sapiens_hsa052100.65720334
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65011886
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.64862476
91Prostate cancer_Homo sapiens_hsa052150.64659146
92Pentose phosphate pathway_Homo sapiens_hsa000300.63663253
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62280726
94Pathways in cancer_Homo sapiens_hsa052000.61880717
95Complement and coagulation cascades_Homo sapiens_hsa046100.60926644
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60732370
97GnRH signaling pathway_Homo sapiens_hsa049120.60286587
98Estrogen signaling pathway_Homo sapiens_hsa049150.60011843
99Platelet activation_Homo sapiens_hsa046110.59440889
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58949746
101mTOR signaling pathway_Homo sapiens_hsa041500.58730799
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.58101006
103One carbon pool by folate_Homo sapiens_hsa006700.58061520
104Renin-angiotensin system_Homo sapiens_hsa046140.57816538
105TGF-beta signaling pathway_Homo sapiens_hsa043500.56186118
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55493371
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.54430945
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53951232
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.52237615
110Notch signaling pathway_Homo sapiens_hsa043300.48091604
111ErbB signaling pathway_Homo sapiens_hsa040120.47285229
112RNA transport_Homo sapiens_hsa030130.44659623
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44045493
114Thyroid cancer_Homo sapiens_hsa052160.42154490
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41843245
116Cell cycle_Homo sapiens_hsa041100.41386169
117Rap1 signaling pathway_Homo sapiens_hsa040150.41129744
118FoxO signaling pathway_Homo sapiens_hsa040680.40569085
119Hippo signaling pathway_Homo sapiens_hsa043900.40024585
120Non-small cell lung cancer_Homo sapiens_hsa052230.38569593
121African trypanosomiasis_Homo sapiens_hsa051430.35076425
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34162892
123Endocytosis_Homo sapiens_hsa041440.33269930
124Endometrial cancer_Homo sapiens_hsa052130.32204273
125Melanoma_Homo sapiens_hsa052180.31601704
126Insulin resistance_Homo sapiens_hsa049310.30795304

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