LIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.59962029
2replication fork processing (GO:0031297)6.80948930
3transcription from mitochondrial promoter (GO:0006390)6.77687745
4embryonic process involved in female pregnancy (GO:0060136)6.34971309
5proline metabolic process (GO:0006560)6.29591651
6maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.99192618
7mitotic chromosome condensation (GO:0007076)5.98714725
8DNA deamination (GO:0045006)5.89914439
9somatic diversification of immune receptors via somatic mutation (GO:0002566)5.52749409
10somatic hypermutation of immunoglobulin genes (GO:0016446)5.52749409
11establishment of apical/basal cell polarity (GO:0035089)5.33989746
12positive regulation of protein homooligomerization (GO:0032464)5.25614542
13DNA strand renaturation (GO:0000733)5.18096465
14regulation of integrin activation (GO:0033623)4.96643729
15nuclear pore complex assembly (GO:0051292)4.81804220
16mitotic G1 DNA damage checkpoint (GO:0031571)4.77299030
17mitochondrial DNA metabolic process (GO:0032042)4.75884703
18oxidative demethylation (GO:0070989)4.75534456
19viral mRNA export from host cell nucleus (GO:0046784)4.69341126
20formation of translation preinitiation complex (GO:0001731)4.58893915
21establishment of monopolar cell polarity (GO:0061162)4.57816841
22establishment or maintenance of monopolar cell polarity (GO:0061339)4.57816841
23regulation of translational fidelity (GO:0006450)4.53083550
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.45946099
25regulation of protein homooligomerization (GO:0032462)4.39562403
26establishment of integrated proviral latency (GO:0075713)4.29123517
27poly(A)+ mRNA export from nucleus (GO:0016973)4.25233526
28protein localization to chromosome, centromeric region (GO:0071459)4.24799562
29G1 DNA damage checkpoint (GO:0044783)4.22388434
30mitotic G1/S transition checkpoint (GO:0044819)4.20786522
31spliceosomal tri-snRNP complex assembly (GO:0000244)4.20121901
32chromosome condensation (GO:0030261)4.18426918
33mRNA cleavage (GO:0006379)4.13421578
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.09545593
35nuclear pore organization (GO:0006999)4.05998660
36dosage compensation (GO:0007549)4.05461409
37protein localization to kinetochore (GO:0034501)4.03781768
38DNA replication checkpoint (GO:0000076)4.01920728
39meiotic chromosome segregation (GO:0045132)3.99986401
40negative regulation of mRNA processing (GO:0050686)3.99356889
41DNA topological change (GO:0006265)3.98697392
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.97769075
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.97769075
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.97769075
45* telomere maintenance via semi-conservative replication (GO:0032201)3.96461387
46regulation of sister chromatid cohesion (GO:0007063)3.95301738
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.91662563
48* DNA strand elongation involved in DNA replication (GO:0006271)3.91489559
49DNA conformation change (GO:0071103)3.90403657
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.89603737
51negative regulation of cell cycle arrest (GO:0071157)3.88546806
52mitotic sister chromatid cohesion (GO:0007064)3.87933518
53kinetochore assembly (GO:0051382)3.87076761
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86893761
55termination of RNA polymerase II transcription (GO:0006369)3.80425001
56heterochromatin organization (GO:0070828)3.79804961
57DNA double-strand break processing (GO:0000729)3.78159566
58mitotic sister chromatid segregation (GO:0000070)3.75593959
59pore complex assembly (GO:0046931)3.73005871
60DNA integration (GO:0015074)3.72085855
61negative regulation of RNA splicing (GO:0033119)3.71029913
62negative regulation of JAK-STAT cascade (GO:0046426)3.70057602
63* base-excision repair (GO:0006284)3.68944927
64* DNA strand elongation (GO:0022616)3.68884439
65embryonic placenta development (GO:0001892)3.66806736
66DNA synthesis involved in DNA repair (GO:0000731)3.66418291
67kinetochore organization (GO:0051383)3.66302469
68histone H4-K12 acetylation (GO:0043983)3.65765275
69establishment of viral latency (GO:0019043)3.63529941
70DNA packaging (GO:0006323)3.60088800
71regulation of RNA export from nucleus (GO:0046831)3.58724930
72protein-DNA complex disassembly (GO:0032986)3.58534921
73nucleosome disassembly (GO:0006337)3.58534921
74regulation of double-strand break repair (GO:2000779)3.58072588
75nuclear envelope disassembly (GO:0051081)3.55028031
76membrane disassembly (GO:0030397)3.55028031
77regulation of posttranscriptional gene silencing (GO:0060147)3.53480752
78regulation of gene silencing by miRNA (GO:0060964)3.53480752
79regulation of gene silencing by RNA (GO:0060966)3.53480752
80positive regulation of chromosome segregation (GO:0051984)3.52843022
81folic acid-containing compound biosynthetic process (GO:0009396)3.50300915
82chromatin assembly (GO:0031497)3.46849359
83positive regulation by host of viral transcription (GO:0043923)3.45268132
84mitotic metaphase plate congression (GO:0007080)3.44751093
85DNA unwinding involved in DNA replication (GO:0006268)3.44427330
86chromatin assembly or disassembly (GO:0006333)3.42814705
87base-excision repair, AP site formation (GO:0006285)3.42730197
88regulation of DNA damage checkpoint (GO:2000001)3.42548603
89mitochondrial RNA metabolic process (GO:0000959)3.41743952
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.37835012
91trophectodermal cell differentiation (GO:0001829)3.36007466
92DNA replication-dependent nucleosome organization (GO:0034723)3.33144281
93DNA replication-dependent nucleosome assembly (GO:0006335)3.33144281
94* telomere maintenance via recombination (GO:0000722)3.29624849
95chromosome segregation (GO:0007059)3.28733042
96sister chromatid segregation (GO:0000819)3.28242115
97maturation of 5.8S rRNA (GO:0000460)3.27705890
98regulation of histone H3-K9 methylation (GO:0051570)3.27374533
99negative regulation of mRNA metabolic process (GO:1903312)3.27234727
100* nucleotide-excision repair, DNA gap filling (GO:0006297)3.25661095
101DNA replication initiation (GO:0006270)3.23721847
102negative regulation of histone methylation (GO:0031061)3.22451153
103cellular response to ATP (GO:0071318)3.21681727
104positive regulation of developmental pigmentation (GO:0048087)3.20383867
105cellular response to zinc ion (GO:0071294)3.19075439
106resolution of meiotic recombination intermediates (GO:0000712)3.16781623
107positive regulation of protein oligomerization (GO:0032461)3.16725818
108peptidyl-arginine omega-N-methylation (GO:0035247)3.15383223
109regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14774296
110CENP-A containing nucleosome assembly (GO:0034080)3.13864761
111glutamine family amino acid biosynthetic process (GO:0009084)3.13380441
112embryonic camera-type eye development (GO:0031076)3.12775875
113apoptotic process involved in morphogenesis (GO:0060561)3.12481941
114ATP-dependent chromatin remodeling (GO:0043044)3.12304378
115chromatin remodeling at centromere (GO:0031055)3.09268690
116nodal signaling pathway (GO:0038092)3.07562845
117DNA replication-independent nucleosome assembly (GO:0006336)3.07250184
118DNA replication-independent nucleosome organization (GO:0034724)3.07250184
119ribosomal small subunit biogenesis (GO:0042274)3.07178886
120negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06437065
121mRNA export from nucleus (GO:0006406)3.04832571
122negative regulation of fatty acid biosynthetic process (GO:0045717)3.03706874
123* mitotic recombination (GO:0006312)3.03703034
124protein complex localization (GO:0031503)3.03356550
125deoxyribonucleotide biosynthetic process (GO:0009263)3.02551807
126mitotic nuclear envelope disassembly (GO:0007077)3.02256261
127pre-miRNA processing (GO:0031054)3.02119200
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01921326
129negative regulation of Ras GTPase activity (GO:0034261)3.01402097
130positive regulation of DNA repair (GO:0045739)3.00455952
131folic acid metabolic process (GO:0046655)3.00210849
132determination of adult lifespan (GO:0008340)2.99981397
133mitotic nuclear envelope reassembly (GO:0007084)2.99651639
134nuclear envelope reassembly (GO:0031468)2.99651639
135face development (GO:0060324)2.99455273
136convergent extension (GO:0060026)2.98734251
137protein localization to chromosome (GO:0034502)2.93773588
138DNA duplex unwinding (GO:0032508)2.92851573
139regulation of chromosome segregation (GO:0051983)2.92341096
140pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.92232147
141nuclear envelope organization (GO:0006998)2.91866916
142DNA geometric change (GO:0032392)2.91584634
143RNA export from nucleus (GO:0006405)2.90202105
144nucleobase biosynthetic process (GO:0046112)2.90121310
145* telomere maintenance via telomere lengthening (GO:0010833)2.89269870
146DNA demethylation (GO:0080111)2.88548170
147* DNA replication (GO:0006260)2.88191989
148IMP biosynthetic process (GO:0006188)2.88120110
149regulation of centriole replication (GO:0046599)2.88111328
150metaphase plate congression (GO:0051310)2.88055898
151mRNA transport (GO:0051028)2.87265157
152* telomere organization (GO:0032200)2.87165304
153positive regulation of DNA-dependent DNA replication (GO:2000105)2.86657847
154* telomere maintenance (GO:0000723)2.86507887
155mRNA stabilization (GO:0048255)2.84870016
156RNA stabilization (GO:0043489)2.84870016
157mRNA splicing, via spliceosome (GO:0000398)2.83924942
158RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83924942
159* DNA ligation (GO:0006266)2.83542775
160negative regulation of chromosome segregation (GO:0051985)2.78300969
161rRNA transcription (GO:0009303)2.78091758
162pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.77310731
163RNA splicing, via transesterification reactions (GO:0000375)2.75922562
164establishment of chromosome localization (GO:0051303)2.75625500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.58916282
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.54351038
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.40649603
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.04187295
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92190905
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75909117
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.74235202
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68601491
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68601491
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68601491
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52291121
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46272409
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38576193
14VDR_21846776_ChIP-Seq_THP-1_Human2.30959045
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28827177
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18474619
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02696511
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99381745
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97772605
20MYC_22102868_ChIP-Seq_BL_Human1.96996791
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.94045131
22* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.93364406
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.92030872
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87892899
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78293233
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77886916
27POU5F1_16518401_ChIP-PET_MESCs_Mouse1.77260882
28TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74781266
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70487740
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68435917
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66049018
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64691445
33NANOG_21062744_ChIP-ChIP_HESCs_Human1.63686554
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61724195
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61064808
36CIITA_25753668_ChIP-Seq_RAJI_Human1.60880514
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57936733
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57193093
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56962791
40XRN2_22483619_ChIP-Seq_HELA_Human1.56468770
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56237298
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55104848
43* ETS1_20019798_ChIP-Seq_JURKAT_Human1.54198994
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54013499
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53809453
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53394936
47* E2F1_21310950_ChIP-Seq_MCF-7_Human1.53240934
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52012983
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51697033
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50459555
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49333350
52* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46063117
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43520790
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.43007658
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41252497
56GABP_19822575_ChIP-Seq_HepG2_Human1.39824697
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39398155
58DCP1A_22483619_ChIP-Seq_HELA_Human1.38646554
59LXR_22292898_ChIP-Seq_THP-1_Human1.37364722
60TTF2_22483619_ChIP-Seq_HELA_Human1.36557049
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32422109
62KDM5A_27292631_Chip-Seq_BREAST_Human1.31915039
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31908964
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.29919232
65FOXP3_21729870_ChIP-Seq_TREG_Human1.27888827
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27189594
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25893148
68POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24693636
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24444518
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24387927
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24264476
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23727075
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22217817
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19734576
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19449738
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19219943
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17535564
78* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17428516
79SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16790426
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16245397
81SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15794508
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14579150
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14046802
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13619734
85TCF7_22412390_ChIP-Seq_EML_Mouse1.13148007
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13068290
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11430488
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11045182
89UTX_26944678_Chip-Seq_JUKART_Human1.10657537
90* MAF_26560356_Chip-Seq_TH1_Human1.10550099
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10481564
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.10418858
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08913005
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.07780121
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07588192
96ZNF263_19887448_ChIP-Seq_K562_Human1.07535678
97VDR_23849224_ChIP-Seq_CD4+_Human1.07207620
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06560166
99NCOR1_26117541_ChIP-Seq_K562_Human1.06375754
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06350689
101NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06029314
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05674643
103RACK7_27058665_Chip-Seq_MCF-7_Human1.04995150
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04301090
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.04072402
106AR_21909140_ChIP-Seq_LNCAP_Human1.03602608
107* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01659808
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01522307
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00994339
110GABP_17652178_ChIP-ChIP_JURKAT_Human1.00984119
111KDM2B_26808549_Chip-Seq_DND41_Human1.00200644
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00154549
113MAF_26560356_Chip-Seq_TH2_Human1.00039435
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99228910
115TFEB_21752829_ChIP-Seq_HELA_Human0.99121947
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98745142
117P68_20966046_ChIP-Seq_HELA_Human0.98422486
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97968755
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97262364
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.96931158
121EGR1_19374776_ChIP-ChIP_THP-1_Human0.96534194
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96313421
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94292302
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94221061
125CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94186819
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93733783
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93642500
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.92852646
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91278817
130VDR_24763502_ChIP-Seq_THP-1_Human0.90230185
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88667417
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88265138
133FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88007152
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87853442
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86299540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.72621652
2MP0005171_absent_coat_pigmentation3.50877801
3* MP0010094_abnormal_chromosome_stability3.32331758
4MP0004957_abnormal_blastocyst_morpholog3.26724509
5MP0003111_abnormal_nucleus_morphology3.13009812
6MP0002009_preneoplasia2.88306971
7MP0004233_abnormal_muscle_weight2.84435876
8MP0003693_abnormal_embryo_hatching2.74444628
9MP0003890_abnormal_embryonic-extraembry2.62321129
10MP0003077_abnormal_cell_cycle2.60633397
11MP0008058_abnormal_DNA_repair2.56773747
12MP0008995_early_reproductive_senescence2.42323650
13MP0008877_abnormal_DNA_methylation2.37423456
14MP0010352_gastrointestinal_tract_polyps2.36399438
15* MP0008057_abnormal_DNA_replication2.34508120
16MP0003786_premature_aging2.34062689
17MP0008932_abnormal_embryonic_tissue2.30949150
18MP0004133_heterotaxia2.20117571
19MP0003283_abnormal_digestive_organ2.18701297
20MP0005076_abnormal_cell_differentiation2.11334238
21MP0003119_abnormal_digestive_system2.09082355
22MP0002653_abnormal_ependyma_morphology2.00492184
23MP0002084_abnormal_developmental_patter1.98041811
24MP0002086_abnormal_extraembryonic_tissu1.95187711
25MP0005174_abnormal_tail_pigmentation1.92807727
26MP0004197_abnormal_fetal_growth/weight/1.88284024
27MP0002085_abnormal_embryonic_tissue1.87846584
28MP0004185_abnormal_adipocyte_glucose1.86453921
29* MP0001697_abnormal_embryo_size1.86032114
30MP0000490_abnormal_crypts_of1.85771617
31MP0001293_anophthalmia1.84386102
32MP0001730_embryonic_growth_arrest1.81703769
33MP0009672_abnormal_birth_weight1.78801659
34MP0001346_abnormal_lacrimal_gland1.77280856
35MP0003567_abnormal_fetal_cardiomyocyte1.77065497
36MP0002877_abnormal_melanocyte_morpholog1.74467504
37MP0002249_abnormal_larynx_morphology1.71732955
38MP0006072_abnormal_retinal_apoptosis1.70730629
39* MP0000350_abnormal_cell_proliferation1.69055314
40* MP0001672_abnormal_embryogenesis/_devel1.63691660
41* MP0005380_embryogenesis_phenotype1.63691660
42MP0004808_abnormal_hematopoietic_stem1.61584225
43MP0002282_abnormal_trachea_morphology1.57528432
44MP0003453_abnormal_keratinocyte_physiol1.56874854
45MP0005451_abnormal_body_composition1.49956234
46MP0010307_abnormal_tumor_latency1.46855757
47* MP0002080_prenatal_lethality1.40427437
48* MP0003763_abnormal_thymus_physiology1.35449617
49MP0002111_abnormal_tail_morphology1.33931201
50* MP0003984_embryonic_growth_retardation1.28653554
51MP0005075_abnormal_melanosome_morpholog1.26872384
52* MP0002019_abnormal_tumor_incidence1.26581985
53* MP0009278_abnormal_bone_marrow1.26505506
54MP0000371_diluted_coat_color1.24494574
55MP0001849_ear_inflammation1.24371036
56* MP0002088_abnormal_embryonic_growth/wei1.24097488
57MP0000470_abnormal_stomach_morphology1.24060050
58MP0002396_abnormal_hematopoietic_system1.20893106
59MP0000537_abnormal_urethra_morphology1.18436604
60MP0000015_abnormal_ear_pigmentation1.18426385
61MP0000313_abnormal_cell_death1.18160794
62* MP0002398_abnormal_bone_marrow1.17283247
63MP0008007_abnormal_cellular_replicative1.16453294
64MP0009053_abnormal_anal_canal1.14740790
65MP0000579_abnormal_nail_morphology1.14630696
66MP0000462_abnormal_digestive_system1.12812669
67MP0009697_abnormal_copulation1.12085388
68MP0004264_abnormal_extraembryonic_tissu1.09694574
69* MP0002722_abnormal_immune_system1.09528143
70MP0002932_abnormal_joint_morphology1.05362895
71MP0000566_synostosis1.04816835
72* MP0005621_abnormal_cell_physiology1.01981846
73MP0000358_abnormal_cell_content/1.01295013
74MP0003172_abnormal_lysosome_physiology1.00961133
75MP0002269_muscular_atrophy1.00488189
76MP0003935_abnormal_craniofacial_develop0.99221130
77MP0003315_abnormal_perineum_morphology0.99206695
78MP0002075_abnormal_coat/hair_pigmentati0.98742410
79* MP0001545_abnormal_hematopoietic_system0.98441689
80* MP0005397_hematopoietic_system_phenotyp0.98441689
81MP0001145_abnormal_male_reproductive0.97916214
82* MP0005384_cellular_phenotype0.96094849
83MP0003755_abnormal_palate_morphology0.96072721
84MP0001340_abnormal_eyelid_morphology0.95938802
85MP0002114_abnormal_axial_skeleton0.94666429
86MP0003718_maternal_effect0.94559789
87MP0002796_impaired_skin_barrier0.91380953
88MP0000432_abnormal_head_morphology0.91222946
89MP0000762_abnormal_tongue_morphology0.90567433
90MP0006035_abnormal_mitochondrial_morpho0.90483834
91MP0005501_abnormal_skin_physiology0.89902392
92MP0008260_abnormal_autophagy0.89013470
93* MP0002429_abnormal_blood_cell0.88747909
94MP0003941_abnormal_skin_development0.88335850
95MP0000639_abnormal_adrenal_gland0.88242705
96MP0009333_abnormal_splenocyte_physiolog0.85910907
97MP0000858_altered_metastatic_potential0.85070367
98MP0002116_abnormal_craniofacial_bone0.84754875
99MP0002210_abnormal_sex_determination0.84370404
100* MP0000689_abnormal_spleen_morphology0.84148495
101MP0003828_pulmonary_edema0.84126643
102MP0003123_paternal_imprinting0.82590826
103MP0000678_abnormal_parathyroid_gland0.81179004
104MP0001186_pigmentation_phenotype0.80192558
105MP0003115_abnormal_respiratory_system0.79341240
106MP0000477_abnormal_intestine_morphology0.79035089
107MP0006292_abnormal_olfactory_placode0.79027060
108MP0002697_abnormal_eye_size0.77818658
109MP0005023_abnormal_wound_healing0.77391626
110MP0003566_abnormal_cell_adhesion0.75678624
111MP0009703_decreased_birth_body0.75335651
112MP0000516_abnormal_urinary_system0.74862524
113MP0005367_renal/urinary_system_phenotyp0.74862524
114MP0002405_respiratory_system_inflammati0.73971665
115MP0000685_abnormal_immune_system0.73856842
116MP0000703_abnormal_thymus_morphology0.73386337
117MP0003385_abnormal_body_wall0.72899167
118MP0001873_stomach_inflammation0.72839742
119MP0002970_abnormal_white_adipose0.71751831
120MP0000653_abnormal_sex_gland0.71735337
121MP0005220_abnormal_exocrine_pancreas0.71115635
122MP0005666_abnormal_adipose_tissue0.71079055
123MP0003705_abnormal_hypodermis_morpholog0.70362004
124MP0000467_abnormal_esophagus_morphology0.70340569
125MP0002089_abnormal_postnatal_growth/wei0.70079645
126MP0000049_abnormal_middle_ear0.69202612
127MP0002163_abnormal_gland_morphology0.68701680
128MP0001929_abnormal_gametogenesis0.66775891
129MP0002092_abnormal_eye_morphology0.66518559
130MP0003699_abnormal_female_reproductive0.66173232
131MP0000428_abnormal_craniofacial_morphol0.66121401
132MP0001348_abnormal_lacrimal_gland0.65516278
133MP0010630_abnormal_cardiac_muscle0.65469035
134MP0003861_abnormal_nervous_system0.65257913
135MP0002060_abnormal_skin_morphology0.65070068
136MP0001784_abnormal_fluid_regulation0.65018888
137MP0000716_abnormal_immune_system0.63539799
138MP0003806_abnormal_nucleotide_metabolis0.60899542
139MP0009379_abnormal_foot_pigmentation0.60020536
140MP0002166_altered_tumor_susceptibility0.59293429
141MP0001915_intracranial_hemorrhage0.58574176
142MP0005058_abnormal_lysosome_morphology0.58426658
143MP0001727_abnormal_embryo_implantation0.57898652
144MP0001286_abnormal_eye_development0.57426704

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.18735530
2Chromsome breakage (HP:0040012)5.54101439
3Rib fusion (HP:0000902)5.34837829
4Facial hemangioma (HP:0000329)4.83768662
5Rectal fistula (HP:0100590)4.56851618
6Rectovaginal fistula (HP:0000143)4.56851618
7Concave nail (HP:0001598)4.49206885
8Poikiloderma (HP:0001029)4.35527998
9Annular pancreas (HP:0001734)4.33702376
10Pustule (HP:0200039)4.31584197
11Intestinal fistula (HP:0100819)4.16442944
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.96749683
13Vaginal fistula (HP:0004320)3.94885032
14Ulnar bowing (HP:0003031)3.82711934
15Increased IgM level (HP:0003496)3.79734945
16Reticulocytopenia (HP:0001896)3.77180154
17Hypochromic microcytic anemia (HP:0004840)3.76284534
18Absent radius (HP:0003974)3.68588751
19Short humerus (HP:0005792)3.67184244
20Aplasia/hypoplasia of the humerus (HP:0006507)3.67038766
21Tongue fasciculations (HP:0001308)3.57883642
22Turricephaly (HP:0000262)3.52682753
23Aplasia involving forearm bones (HP:0009822)3.45928898
24Absent forearm bone (HP:0003953)3.45928898
25Alopecia of scalp (HP:0002293)3.44556455
26Absent thumb (HP:0009777)3.39891369
27Intestinal atresia (HP:0011100)3.33675370
28Abnormality of the preputium (HP:0100587)3.32511706
29Patellar aplasia (HP:0006443)3.30466252
30Volvulus (HP:0002580)3.30433639
31Selective tooth agenesis (HP:0001592)3.29375831
32Orthostatic hypotension (HP:0001278)3.29031434
33Hyperacusis (HP:0010780)3.29027629
34Abnormal hemoglobin (HP:0011902)3.27702135
35Basal cell carcinoma (HP:0002671)3.24700503
36Muscle fibrillation (HP:0010546)3.23995820
37Meckel diverticulum (HP:0002245)3.22804582
38Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21338620
39Squamous cell carcinoma (HP:0002860)3.18361243
40Coronal craniosynostosis (HP:0004440)3.15694235
41Increased nuchal translucency (HP:0010880)3.12736990
42Vertebral hypoplasia (HP:0008417)3.09635508
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.09635508
44Aplasia/Hypoplasia of the patella (HP:0006498)3.03873857
45High anterior hairline (HP:0009890)2.97935549
46Male infertility (HP:0003251)2.96556177
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.92688350
48Broad alveolar ridges (HP:0000187)2.89506566
49Abnormality of the labia minora (HP:0012880)2.88404096
50Abnormality of male internal genitalia (HP:0000022)2.86403780
51Microvesicular hepatic steatosis (HP:0001414)2.83957529
52Abnormality of chromosome stability (HP:0003220)2.81575573
53Congenital hip dislocation (HP:0001374)2.78413916
54Anteriorly placed anus (HP:0001545)2.77759819
55Multiple enchondromatosis (HP:0005701)2.77178991
56Premature graying of hair (HP:0002216)2.72236645
57Broad distal phalanx of finger (HP:0009836)2.69506896
58Myelodysplasia (HP:0002863)2.67141774
59Abnormality of reticulocytes (HP:0004312)2.65775483
60Abnormality of the astrocytes (HP:0100707)2.65324441
61Astrocytoma (HP:0009592)2.65324441
62Small intestinal stenosis (HP:0012848)2.61533166
63Duodenal stenosis (HP:0100867)2.61533166
64Abnormality of the aortic arch (HP:0012303)2.61277955
65Alacrima (HP:0000522)2.60934627
66Short chin (HP:0000331)2.59994864
67Abnormal number of incisors (HP:0011064)2.58079572
68Abnormality of the carotid arteries (HP:0005344)2.55607291
69Abnormality of DNA repair (HP:0003254)2.53758760
70Abnormality of cochlea (HP:0000375)2.52133427
71Premature skin wrinkling (HP:0100678)2.51597817
72Cholecystitis (HP:0001082)2.46822492
73Abnormal gallbladder physiology (HP:0012438)2.46822492
74Ependymoma (HP:0002888)2.45106480
75Pancreatic islet-cell hyperplasia (HP:0004510)2.44804401
76Insomnia (HP:0100785)2.42136273
77Abnormality of the ileum (HP:0001549)2.40382650
78Acute lymphatic leukemia (HP:0006721)2.40166669
79Progressive muscle weakness (HP:0003323)2.39596581
80Ectopic kidney (HP:0000086)2.37815133
81Dysautonomia (HP:0002459)2.37596786
82Hypochromic anemia (HP:0001931)2.36297401
83Hamartoma (HP:0010566)2.35972669
84Albinism (HP:0001022)2.34413953
85Overlapping toe (HP:0001845)2.33978033
86Hypotelorism (HP:0000601)2.33851302
87Abnormality of the fingertips (HP:0001211)2.33089558
88Proximal placement of thumb (HP:0009623)2.32786812
89Capillary hemangiomas (HP:0005306)2.30024738
90Cafe-au-lait spot (HP:0000957)2.29614744
91Neoplasm of the oral cavity (HP:0100649)2.29519300
92Diaphragmatic weakness (HP:0009113)2.28633056
93Hypoplasia of the radius (HP:0002984)2.27731058
94Duplication of thumb phalanx (HP:0009942)2.27506481
95Vertebral fusion (HP:0002948)2.27025110
96Gastrointestinal atresia (HP:0002589)2.26050949
97High pitched voice (HP:0001620)2.25117360
98IgA deficiency (HP:0002720)2.25007811
99Horseshoe kidney (HP:0000085)2.23706947
100Hypotrichosis (HP:0001006)2.22922539
101Deviation of the thumb (HP:0009603)2.22331166
102Large for gestational age (HP:0001520)2.22076584
103Breast hypoplasia (HP:0003187)2.21400555
104Abnormality of cells of the erythroid lineage (HP:0012130)2.17012252
105Short thumb (HP:0009778)2.15436752
106Increased number of teeth (HP:0011069)2.15012633
107Choanal stenosis (HP:0000452)2.14435312
108Bifid uvula (HP:0000193)2.14106461
109Reticulocytosis (HP:0001923)2.13004849
110Glioma (HP:0009733)2.09816855
111Short 5th finger (HP:0009237)2.07987863
11211 pairs of ribs (HP:0000878)2.06598697
113Embryonal renal neoplasm (HP:0011794)2.05391930
114Abnormality of the calcaneus (HP:0008364)2.05180246
115Impulsivity (HP:0100710)2.04571192
116Bowed forearm bones (HP:0003956)2.04365643
117Bowing of the arm (HP:0006488)2.04365643
118Abnormality of the duodenum (HP:0002246)2.03803068
119Ragged-red muscle fibers (HP:0003200)2.00304055
120Decreased lacrimation (HP:0000633)1.99639105
121Clubbing of toes (HP:0100760)1.99452122
122Cerebral aneurysm (HP:0004944)1.99187760
123Split hand (HP:0001171)1.98523174
124Urethral obstruction (HP:0000796)1.98001448
125Urinary glycosaminoglycan excretion (HP:0003541)1.97537349
126Mucopolysacchariduria (HP:0008155)1.97537349
127Spinal muscular atrophy (HP:0007269)1.97524031
128Joint stiffness (HP:0001387)1.96884619
129Rhabdomyosarcoma (HP:0002859)1.95815256
130Flared metaphyses (HP:0003015)1.95637551
131Duplicated collecting system (HP:0000081)1.93998048
132Abnormal number of erythroid precursors (HP:0012131)1.93606689
133Trigonocephaly (HP:0000243)1.91390662
134Abdominal situs inversus (HP:0003363)1.91101100
135Abnormality of abdominal situs (HP:0011620)1.91101100
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89502133
137Pallor (HP:0000980)1.89239763
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89188401
139Absent epiphyses (HP:0010577)1.89188401
140Pointed chin (HP:0000307)1.88084929
141Pseudobulbar signs (HP:0002200)1.87876452
142Aplasia/Hypoplasia of the thymus (HP:0010515)1.87102684
143Atresia of the external auditory canal (HP:0000413)1.86593456
144Agammaglobulinemia (HP:0004432)1.86131863
145Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85460138
146Arteriovenous malformation (HP:0100026)1.85431304
147Medulloblastoma (HP:0002885)1.85391771
148Seborrheic dermatitis (HP:0001051)1.85085583
149Aplasia of the musculature (HP:0100854)1.84591550
150Deep palmar crease (HP:0006191)1.84342381
151Long palpebral fissure (HP:0000637)1.81709558
152Hemivertebrae (HP:0002937)1.81413954
153Overriding aorta (HP:0002623)1.81047092
154Missing ribs (HP:0000921)1.80898929
155Disproportionate tall stature (HP:0001519)1.80227085
156Birth length less than 3rd percentile (HP:0003561)1.79918744
157Elfin facies (HP:0004428)1.79819211
158Entropion (HP:0000621)1.79711620
159Long eyelashes (HP:0000527)1.79053238
160Growth hormone excess (HP:0000845)1.78175989
161Progressive external ophthalmoplegia (HP:0000590)1.77902669
162Cellulitis (HP:0100658)1.77665104
163Abnormality of chromosome segregation (HP:0002916)1.77664958
164Recurrent viral infections (HP:0004429)1.77482033
165Broad face (HP:0000283)1.77354774
166Sloping forehead (HP:0000340)1.77209731
167Morphological abnormality of the inner ear (HP:0011390)1.76751415
168Embryonal neoplasm (HP:0002898)1.75199563
169Shawl scrotum (HP:0000049)1.75147797
170Hypoplasia of the ulna (HP:0003022)1.75066818
171Bone marrow hypocellularity (HP:0005528)1.74480906
172Muscle fiber atrophy (HP:0100295)1.74123251
173Broad thumb (HP:0011304)1.73444518
174Choanal atresia (HP:0000453)1.72447523
175Hypergonadotropic hypogonadism (HP:0000815)1.72166363
176Abnormality of pyrimidine metabolism (HP:0004353)1.71982897
177Cortical dysplasia (HP:0002539)1.71329873
178Nephroblastoma (Wilms tumor) (HP:0002667)1.71161394
179Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70981190
180Triphalangeal thumb (HP:0001199)1.69913921
181Deep philtrum (HP:0002002)1.68637935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.63604007
2MAPK154.42009657
3DDR24.40997669
4MAP3K64.00736039
5SMG13.88634761
6MAP3K113.12031423
7VRK22.94249057
8MATK2.71495168
9TYRO32.63928118
10FGR2.52886883
11NME22.45789804
12PINK12.34115273
13UHMK12.33382164
14DAPK12.33360869
15CDK72.23821826
16CDC72.20153411
17YES12.10091749
18BMX2.08523896
19PIM22.05001259
20PLK41.89564598
21CSK1.89000096
22PRKD21.86275013
23DYRK1B1.86100882
24PDGFRA1.81162148
25CDK61.68475980
26WEE11.66303019
27PIM11.57212776
28MAP3K101.52807158
29CDK121.52746727
30CHEK21.47539201
31PLK11.42943524
32NEK21.37078393
33BUB11.28754869
34RPS6KC11.26995221
35RPS6KL11.26995221
36TRPM71.26830387
37AKT31.26377020
38LATS21.25453972
39ATR1.19763709
40KDR1.18165418
41RPS6KB21.17669347
42TAF11.17020815
43DYRK31.14507247
44RPS6KA61.10174962
45VRK11.06862779
46TSSK61.03829038
47BRD41.03756379
48MAPK111.03726249
49FGFR41.02199418
50IRAK31.00798021
51CDC42BPA0.99620819
52EIF2AK10.98689799
53PBK0.96845654
54NEK10.93142239
55MAP2K20.92851572
56ZAK0.91579775
57TTK0.90676301
58GSK3A0.88214090
59SIK10.88098327
60PKN20.84490946
61MTOR0.84460183
62CLK10.83310263
63AURKB0.78945673
64CDK40.77654915
65NME10.76724106
66PLK30.75694472
67* CDK20.75442545
68AURKA0.73650129
69ERN10.72575422
70EPHA20.72012206
71CDK90.71850372
72RPS6KA10.69099372
73ATM0.64531837
74RPS6KA40.64520544
75LRRK20.63440240
76HIPK20.62704109
77MAP3K130.60843346
78* CHEK10.60795922
79BRAF0.58625813
80TAOK20.58549585
81TLK10.56661214
82TESK10.55349281
83ALK0.54406182
84STK100.54032553
85MELK0.53877739
86PHKG20.53760810
87PHKG10.53760810
88* CSNK2A10.51731118
89CCNB10.50222873
90BRSK20.49095750
91MAP3K80.47906832
92PRKAA10.45561048
93PAK40.45052643
94* CDK10.44974685
95MST1R0.44326026
96TESK20.44263053
97SRPK10.43846193
98STK30.43272067
99SIK20.43168021
100EEF2K0.42327054
101STK40.41742543
102PRPF4B0.41730822
103RPS6KB10.41658493
104MKNK10.41603020
105MAPK140.41106866
106CDK150.40722081
107MAPK10.40703318
108LYN0.40503897
109EGFR0.39832147
110* CSNK2A20.39448560
111ACVR1B0.38883179
112TTN0.38310603
113TRIB30.38098627
114RAF10.37738806
115PTK60.37162803
116AKT20.36389020
117CDK180.36117726
118EIF2AK20.35925445
119ERBB30.35539976
120MKNK20.35174153
121MAPK30.34163555
122BRSK10.33908354
123RIPK40.33682835
124DYRK20.33469368
125CDK140.32356332
126CDK80.32154165
127MAP2K30.32101303
128BTK0.31918453
129GRK60.31801714
130GSK3B0.31445053
131PAK10.29004420
132CSF1R0.28943435
133PAK20.28918684
134SCYL20.28601193
135MAP4K10.28532285
136PRKDC0.26805147
137MAPK100.26420061
138PDGFRB0.26389057
139CDK11A0.25294853
140MAPKAPK20.25284448
141PASK0.24895693
142AKT10.24630698
143CSNK1G10.24123530
144MAPK40.22777650

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030304.72611396
2* Mismatch repair_Homo sapiens_hsa034304.55464871
3* Base excision repair_Homo sapiens_hsa034104.04132609
4Fatty acid biosynthesis_Homo sapiens_hsa000613.66202496
5Spliceosome_Homo sapiens_hsa030403.13341465
6Homologous recombination_Homo sapiens_hsa034403.04171054
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94523125
8RNA transport_Homo sapiens_hsa030132.79224382
9Fanconi anemia pathway_Homo sapiens_hsa034602.50700523
10Cell cycle_Homo sapiens_hsa041102.46762806
11mRNA surveillance pathway_Homo sapiens_hsa030152.38740203
12* Nucleotide excision repair_Homo sapiens_hsa034202.32894364
13Ribosome_Homo sapiens_hsa030102.16507534
14p53 signaling pathway_Homo sapiens_hsa041151.93924401
15One carbon pool by folate_Homo sapiens_hsa006701.89264976
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81664147
17Notch signaling pathway_Homo sapiens_hsa043301.73940290
18Hippo signaling pathway_Homo sapiens_hsa043901.67142528
19Hedgehog signaling pathway_Homo sapiens_hsa043401.62792120
20Pentose phosphate pathway_Homo sapiens_hsa000301.60223563
21mTOR signaling pathway_Homo sapiens_hsa041501.54172854
22Biosynthesis of amino acids_Homo sapiens_hsa012301.44434128
23Adherens junction_Homo sapiens_hsa045201.36822091
24Arginine and proline metabolism_Homo sapiens_hsa003301.29450542
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28110544
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27686652
27Basal cell carcinoma_Homo sapiens_hsa052171.23700534
28TGF-beta signaling pathway_Homo sapiens_hsa043501.23188585
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22344893
30RNA polymerase_Homo sapiens_hsa030201.21923479
31Bladder cancer_Homo sapiens_hsa052191.21482061
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18242120
33Oocyte meiosis_Homo sapiens_hsa041141.17589820
34Carbon metabolism_Homo sapiens_hsa012001.16959318
35Pyrimidine metabolism_Homo sapiens_hsa002401.15745089
36Non-small cell lung cancer_Homo sapiens_hsa052231.12606383
37Sulfur relay system_Homo sapiens_hsa041221.12510035
38Proteasome_Homo sapiens_hsa030501.11707321
39RNA degradation_Homo sapiens_hsa030181.11222263
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09952495
41Circadian rhythm_Homo sapiens_hsa047101.08587339
42Lysine degradation_Homo sapiens_hsa003101.03886226
43Non-homologous end-joining_Homo sapiens_hsa034501.03377750
44Wnt signaling pathway_Homo sapiens_hsa043100.99845151
45MicroRNAs in cancer_Homo sapiens_hsa052060.99420202
46Folate biosynthesis_Homo sapiens_hsa007900.98304626
47Shigellosis_Homo sapiens_hsa051310.97909216
48Primary immunodeficiency_Homo sapiens_hsa053400.97022961
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96575507
50Basal transcription factors_Homo sapiens_hsa030220.91647913
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91631195
52Colorectal cancer_Homo sapiens_hsa052100.91549853
53Viral carcinogenesis_Homo sapiens_hsa052030.89501449
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89412044
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88159515
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85581377
57Small cell lung cancer_Homo sapiens_hsa052220.78256732
58Fructose and mannose metabolism_Homo sapiens_hsa000510.77573756
59N-Glycan biosynthesis_Homo sapiens_hsa005100.75596731
60Thyroid cancer_Homo sapiens_hsa052160.73083280
61Epstein-Barr virus infection_Homo sapiens_hsa051690.72293786
62Chronic myeloid leukemia_Homo sapiens_hsa052200.72169728
63VEGF signaling pathway_Homo sapiens_hsa043700.68622965
64Alcoholism_Homo sapiens_hsa050340.67845900
65Herpes simplex infection_Homo sapiens_hsa051680.67448838
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66630693
67Viral myocarditis_Homo sapiens_hsa054160.65871455
68HTLV-I infection_Homo sapiens_hsa051660.64426419
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59591652
70Tight junction_Homo sapiens_hsa045300.57824656
71Legionellosis_Homo sapiens_hsa051340.55929287
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55499342
73Other glycan degradation_Homo sapiens_hsa005110.55224803
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55023740
75Acute myeloid leukemia_Homo sapiens_hsa052210.54164196
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51748892
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48263128
78Fatty acid metabolism_Homo sapiens_hsa012120.48097914
79Glutathione metabolism_Homo sapiens_hsa004800.45723205
80Systemic lupus erythematosus_Homo sapiens_hsa053220.45579615
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43672432
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.42992303
83Galactose metabolism_Homo sapiens_hsa000520.41764556
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41764270
85Glioma_Homo sapiens_hsa052140.41618985
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38910432
87Hepatitis B_Homo sapiens_hsa051610.38889012
88Pathways in cancer_Homo sapiens_hsa052000.36432004
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.36068385
90AMPK signaling pathway_Homo sapiens_hsa041520.35081245
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.34975164
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33702653
93Proteoglycans in cancer_Homo sapiens_hsa052050.33351275
94Selenocompound metabolism_Homo sapiens_hsa004500.33089766
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.32954690
96Vitamin B6 metabolism_Homo sapiens_hsa007500.32743807
97Prostate cancer_Homo sapiens_hsa052150.31875572
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31676588
99Pyruvate metabolism_Homo sapiens_hsa006200.31540670
100ErbB signaling pathway_Homo sapiens_hsa040120.31317236
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30359704
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.29870508
103Measles_Homo sapiens_hsa051620.29439826
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29084006
105Influenza A_Homo sapiens_hsa051640.28898332
106Dorso-ventral axis formation_Homo sapiens_hsa043200.28366384
107Endometrial cancer_Homo sapiens_hsa052130.27726306
108Gap junction_Homo sapiens_hsa045400.26864714
109Inositol phosphate metabolism_Homo sapiens_hsa005620.26392463
110Choline metabolism in cancer_Homo sapiens_hsa052310.25897661
111Insulin signaling pathway_Homo sapiens_hsa049100.24855153
112HIF-1 signaling pathway_Homo sapiens_hsa040660.24791704
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.23257587
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22975861
115Pancreatic cancer_Homo sapiens_hsa052120.22015451
116Purine metabolism_Homo sapiens_hsa002300.20268553
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.19812144
118Apoptosis_Homo sapiens_hsa042100.19699532
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19263507
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19221001
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16539861
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15121981
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14998596
124B cell receptor signaling pathway_Homo sapiens_hsa046620.14789966

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