LIG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.21770759
2central nervous system myelination (GO:0022010)6.21770759
3neuron cell-cell adhesion (GO:0007158)5.18790857
4fatty acid elongation (GO:0030497)4.79730665
5nerve growth factor signaling pathway (GO:0038180)4.51287146
6presynaptic membrane assembly (GO:0097105)4.34048780
7establishment of mitochondrion localization (GO:0051654)3.97171508
8presynaptic membrane organization (GO:0097090)3.96974727
9neurotransmitter catabolic process (GO:0042135)3.96533579
10negative regulation of neurotransmitter transport (GO:0051589)3.92516912
11L-serine transport (GO:0015825)3.88150143
12apical protein localization (GO:0045176)3.83216177
13long-chain fatty acid biosynthetic process (GO:0042759)3.80157339
14glycerophospholipid catabolic process (GO:0046475)3.73261085
15neuron recognition (GO:0008038)3.71625075
16myelination (GO:0042552)3.71550305
17asymmetric protein localization (GO:0008105)3.71229282
18axon ensheathment (GO:0008366)3.69101308
19ensheathment of neurons (GO:0007272)3.69101308
20synaptic vesicle maturation (GO:0016188)3.54565797
21cholesterol biosynthetic process (GO:0006695)3.52555812
22substantia nigra development (GO:0021762)3.49119490
23regulation of synaptic vesicle exocytosis (GO:2000300)3.44548294
24axonal fasciculation (GO:0007413)3.42781097
25vesicle transport along microtubule (GO:0047496)3.35303212
26regulation of protein glycosylation (GO:0060049)3.35098126
27cellular response to ethanol (GO:0071361)3.34487833
28positive regulation of protein depolymerization (GO:1901881)3.31235447
29negative regulation of protein localization to cell surface (GO:2000009)3.30359496
30gamma-aminobutyric acid transport (GO:0015812)3.30334507
31negative regulation of neurotransmitter secretion (GO:0046929)3.27992709
32regulation of Rac protein signal transduction (GO:0035020)3.27241360
33regulation of glucokinase activity (GO:0033131)3.24832998
34regulation of hexokinase activity (GO:1903299)3.24832998
35microtubule polymerization or depolymerization (GO:0031109)3.24619988
36negative regulation of neurological system process (GO:0031645)3.24033644
37eye photoreceptor cell differentiation (GO:0001754)3.22233217
38photoreceptor cell differentiation (GO:0046530)3.22233217
39spermatid nucleus differentiation (GO:0007289)3.21819157
40serine transport (GO:0032329)3.21088678
41dendritic spine morphogenesis (GO:0060997)3.19911913
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15558287
43magnesium ion transport (GO:0015693)3.11835346
44synaptic vesicle exocytosis (GO:0016079)3.09434094
45ATP synthesis coupled proton transport (GO:0015986)3.08905726
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08905726
47dopamine biosynthetic process (GO:0042416)3.06123797
48macroautophagy (GO:0016236)3.02838710
49positive regulation of macroautophagy (GO:0016239)3.02140150
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01469274
51mitochondrion transport along microtubule (GO:0047497)3.01469274
52microtubule depolymerization (GO:0007019)3.00947074
53sterol biosynthetic process (GO:0016126)2.99680490
54positive regulation of synapse assembly (GO:0051965)2.99165502
55membrane assembly (GO:0071709)2.98034350
56limb bud formation (GO:0060174)2.97792602
57cell migration in hindbrain (GO:0021535)2.97293468
58protein targeting to Golgi (GO:0000042)2.97249342
59cellular response to nerve growth factor stimulus (GO:1990090)2.97168203
60response to nerve growth factor (GO:1990089)2.97168203
61regulation of clathrin-mediated endocytosis (GO:2000369)2.96261586
62gamma-aminobutyric acid signaling pathway (GO:0007214)2.94578976
63regulation of synaptic vesicle transport (GO:1902803)2.94360979
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92762302
65protein localization to synapse (GO:0035418)2.92391421
66transmission of nerve impulse (GO:0019226)2.91728895
67dendrite development (GO:0016358)2.89249272
68isoprenoid biosynthetic process (GO:0008299)2.86628369
69establishment of protein localization to Golgi (GO:0072600)2.84871483
70positive regulation of neurotransmitter transport (GO:0051590)2.84767995
71Golgi to endosome transport (GO:0006895)2.83498990
72cerebellar granule cell differentiation (GO:0021707)2.82997566
73negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.82615387
74positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82362869
75layer formation in cerebral cortex (GO:0021819)2.80254717
76nucleobase catabolic process (GO:0046113)2.78372086
77regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.78214925
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77670220
79negative regulation of dendrite development (GO:2000171)2.76082483
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.74610210
81positive regulation of neurotransmitter secretion (GO:0001956)2.74571890
82establishment of nucleus localization (GO:0040023)2.73637817
83positive regulation of cellular response to oxidative stress (GO:1900409)2.72705597
84positive regulation of response to oxidative stress (GO:1902884)2.72705597
85vocalization behavior (GO:0071625)2.72359145
86* V(D)J recombination (GO:0033151)2.71931679
87organelle transport along microtubule (GO:0072384)2.70237824
88negative regulation of dendrite morphogenesis (GO:0050774)2.68120254
89cellular ketone body metabolic process (GO:0046950)2.67902303
90regulation of dendritic spine morphogenesis (GO:0061001)2.66609724
91regulation of cAMP-dependent protein kinase activity (GO:2000479)2.65898112
92myelin maintenance (GO:0043217)2.64672800
93chaperone-mediated protein transport (GO:0072321)2.64096266
94negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.63726159
95detection of calcium ion (GO:0005513)2.63439803
96regulation of vesicle fusion (GO:0031338)2.63142996
97clathrin coat assembly (GO:0048268)2.59312768
98neuron-neuron synaptic transmission (GO:0007270)2.59022114
99piRNA metabolic process (GO:0034587)2.56306260
100brain morphogenesis (GO:0048854)2.55420716
101regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.55201497
102microtubule severing (GO:0051013)2.53973072
103pyrimidine nucleobase catabolic process (GO:0006208)2.53924061
104retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53887100
105startle response (GO:0001964)2.53549281
106* establishment of viral latency (GO:0019043)2.53066041
107establishment of melanosome localization (GO:0032401)2.52984204
108negative regulation of axonogenesis (GO:0050771)2.52866641
109regulation of DNA methylation (GO:0044030)2.50874846
110ketone body metabolic process (GO:1902224)2.49453394
111Rap protein signal transduction (GO:0032486)2.49195803
112protein neddylation (GO:0045116)2.49152179
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.48015023
114positive regulation of protein complex disassembly (GO:0043243)2.47960307
115regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47334625
116dendrite morphogenesis (GO:0048813)2.46934818
117SMAD protein complex assembly (GO:0007183)2.46869741
118oligodendrocyte differentiation (GO:0048709)2.46831868
119vesicle localization (GO:0051648)2.46735720
120positive regulation of glycolytic process (GO:0045821)2.46509109
121positive regulation of response to nutrient levels (GO:0032109)2.46460916
122positive regulation of response to extracellular stimulus (GO:0032106)2.46460916
123maternal behavior (GO:0042711)2.46065213
124regulation of gene expression by genetic imprinting (GO:0006349)2.46042145
125positive regulation of actin filament depolymerization (GO:0030836)2.44782113
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.44602460
127neurotransmitter-gated ion channel clustering (GO:0072578)2.44365567
128negative regulation of microtubule polymerization (GO:0031115)2.44298855
129lateral sprouting from an epithelium (GO:0060601)2.43972707
130regulation of short-term neuronal synaptic plasticity (GO:0048172)2.43889456
131establishment of pigment granule localization (GO:0051905)2.43843082
132mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.40515895
133positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40435134
134regulation of receptor internalization (GO:0002090)2.40342693
135organ growth (GO:0035265)2.40115946
136positive regulation of meiosis (GO:0045836)2.39155561
137endoplasmic reticulum organization (GO:0007029)2.39033179
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38991494
139* establishment of integrated proviral latency (GO:0075713)2.38721187
140glutamate receptor signaling pathway (GO:0007215)2.38632904
141melanosome transport (GO:0032402)2.37772398
142regulation of synapse structural plasticity (GO:0051823)2.36251558
143regulation of postsynaptic membrane potential (GO:0060078)2.35615528
144inositol phosphate catabolic process (GO:0071545)2.34919673
145intra-Golgi vesicle-mediated transport (GO:0006891)2.34256238
146regulation of dendrite morphogenesis (GO:0048814)2.33947103
147righting reflex (GO:0060013)2.33790776
148interleukin-6-mediated signaling pathway (GO:0070102)2.32675321
149protein K11-linked deubiquitination (GO:0035871)2.31885907
150protein localization to cilium (GO:0061512)2.31468447
151neurotransmitter secretion (GO:0007269)2.31269027
152positive regulation of receptor internalization (GO:0002092)2.30945586
153mechanosensory behavior (GO:0007638)2.30526639
154regulation of collateral sprouting (GO:0048670)2.30237260
155regulation of neurotransmitter secretion (GO:0046928)2.29815420
156neuron remodeling (GO:0016322)2.29770378
157transferrin transport (GO:0033572)2.29252152
158cell wall macromolecule catabolic process (GO:0016998)2.29097396
159regulation of energy homeostasis (GO:2000505)2.28955099
160pigment granule transport (GO:0051904)2.28907217
161regulation of meiosis I (GO:0060631)2.28821819
162protein depolymerization (GO:0051261)2.28120163
163phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.27558777
164regulation of synaptic transmission, glutamatergic (GO:0051966)2.27360463
165positive regulation of meiotic cell cycle (GO:0051446)2.27305089
166positive regulation of neurological system process (GO:0031646)2.27080963
167regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.26365802
168interferon-gamma production (GO:0032609)2.26038286
169trivalent inorganic cation transport (GO:0072512)2.25502853
170ferric iron transport (GO:0015682)2.25502853
171long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.25476193
172synapse organization (GO:0050808)2.25450115
173positive regulation of insulin receptor signaling pathway (GO:0046628)2.24309361
174regulation of sarcomere organization (GO:0060297)2.23757324
175glutamate secretion (GO:0014047)2.22763482
176negative regulation of exocytosis (GO:0045920)2.22384868
177regulation of transmission of nerve impulse (GO:0051969)2.21741936
178synaptic transmission, glutamatergic (GO:0035249)2.21699111
179ionotropic glutamate receptor signaling pathway (GO:0035235)2.20642842
180regulation of excitatory postsynaptic membrane potential (GO:0060079)2.20636730
181regulation of filopodium assembly (GO:0051489)2.19461075
182regulation of interferon-beta biosynthetic process (GO:0045357)2.18929854
183negative regulation of interleukin-17 production (GO:0032700)2.18527194
184regulation of neurotransmitter transport (GO:0051588)2.18238248
185COPII vesicle coating (GO:0048208)2.17967469
186regulation of dendritic spine development (GO:0060998)2.17589937
187regulation of synaptic transmission, GABAergic (GO:0032228)2.15175855
188establishment of protein localization to vacuole (GO:0072666)2.14750150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.83324507
2GBX2_23144817_ChIP-Seq_PC3_Human3.62029666
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04942762
4FUS_26573619_Chip-Seq_HEK293_Human3.02257566
5TAF15_26573619_Chip-Seq_HEK293_Human2.94931487
6AR_21572438_ChIP-Seq_LNCaP_Human2.71201410
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53201553
8VDR_22108803_ChIP-Seq_LS180_Human2.41778619
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41424430
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35733931
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.25481533
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.25418171
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20262459
14ER_23166858_ChIP-Seq_MCF-7_Human2.20061884
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14334102
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13110522
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11477800
18OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06632089
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06299473
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00283635
21* CBX2_27304074_Chip-Seq_ESCs_Mouse1.98365755
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92451374
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91921425
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.91136411
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90311325
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90131691
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81525612
28* SMAD3_21741376_ChIP-Seq_EPCs_Human1.80448051
29* P300_19829295_ChIP-Seq_ESCs_Human1.80036858
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.76284350
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71316528
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70046094
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68262816
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.67473497
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66812582
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.66453649
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65866269
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62557500
39STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.61484704
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.60075504
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58978011
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58336264
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58208863
44STAT3_23295773_ChIP-Seq_U87_Human1.57074162
45SMAD4_21799915_ChIP-Seq_A2780_Human1.56795582
46RNF2_27304074_Chip-Seq_NSC_Mouse1.56126633
47* REST_21632747_ChIP-Seq_MESCs_Mouse1.53734520
48CBP_20019798_ChIP-Seq_JUKART_Human1.52101550
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52101550
50IGF1R_20145208_ChIP-Seq_DFB_Human1.50337777
51ZNF274_21170338_ChIP-Seq_K562_Hela1.49848008
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.49420919
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48210713
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.48067599
55P53_22387025_ChIP-Seq_ESCs_Mouse1.46601478
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46039288
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45763539
58GATA1_22025678_ChIP-Seq_K562_Human1.45566752
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45496023
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43471958
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43471958
62TP53_18474530_ChIP-ChIP_U2OS_Human1.43106291
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.42698441
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.41968844
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40702258
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40571165
67EWS_26573619_Chip-Seq_HEK293_Human1.40040244
68* TCF4_23295773_ChIP-Seq_U87_Human1.37386657
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36703159
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36541694
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36541694
72BCAT_22108803_ChIP-Seq_LS180_Human1.36003463
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.34316325
74* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34033186
75* JUN_21703547_ChIP-Seq_K562_Human1.33327807
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31474327
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31283043
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29794187
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29272651
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29185428
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.28474951
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.27326932
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26916416
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.26511788
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26385920
86P300_18555785_Chip-Seq_ESCs_Mouse1.26371316
87* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26045638
88* WT1_19549856_ChIP-ChIP_CCG9911_Human1.25452445
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24706367
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23973231
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.23663039
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.23372247
93CDX2_22108803_ChIP-Seq_LS180_Human1.20750659
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20375974
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20328981
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20173110
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.19524567
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.19451472
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19246315
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19164719
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18186340
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18021518
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.17872572
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17181790
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16506861
106OCT4_18555785_Chip-Seq_ESCs_Mouse1.16133549
107TP53_16413492_ChIP-PET_HCT116_Human1.14746194
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.14350726
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.14166301
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13960071
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13954882
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13829188
113* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13134133
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.12067711
115SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11588720
116SOX9_26525672_Chip-Seq_HEART_Mouse1.11044537
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10957852
118RUNX2_22187159_ChIP-Seq_PCA_Human1.10089258
119KDM2B_26808549_Chip-Seq_REH_Human1.10065507
120PU1_27457419_Chip-Seq_LIVER_Mouse1.09829364
121CTCF_18555785_Chip-Seq_ESCs_Mouse1.09479809
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09438667
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.09191630
124POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.08623016
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.08000836
126* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07610655
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07086173
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06918019
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06889215
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06520533
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.06137984
132AR_25329375_ChIP-Seq_VCAP_Human1.05670643
133TP63_23658742_ChIP-Seq_EP156T_Human1.04512530
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04506387
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.04190079
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03742064
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03330490
138TCF4_22108803_ChIP-Seq_LS180_Human1.02431445
139* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01793924
140IRF8_27001747_Chip-Seq_BMDM_Mouse1.01308670
141REST_18959480_ChIP-ChIP_MESCs_Mouse1.01212363
142SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01152900
143P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00987729
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00525391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.65488756
2MP0004270_analgesia3.75466328
3MP0001529_abnormal_vocalization3.46229536
4MP0000778_abnormal_nervous_system2.85469262
5MP0003950_abnormal_plasma_membrane2.84847241
6MP0003195_calcinosis2.83005058
7MP0010234_abnormal_vibrissa_follicle2.71615642
8MP0004859_abnormal_synaptic_plasticity2.49724051
9MP0000920_abnormal_myelination2.46046284
10MP0001905_abnormal_dopamine_level2.43544722
11MP0003635_abnormal_synaptic_transmissio2.32679598
12MP0002909_abnormal_adrenal_gland2.31414842
13MP0002822_catalepsy2.27046518
14MP0003300_gastrointestinal_ulcer2.03680771
15MP0003303_peritoneal_inflammation2.00808488
16MP0003329_amyloid_beta_deposits1.96610298
17MP0005409_darkened_coat_color1.95299729
18MP0001486_abnormal_startle_reflex1.94463177
19MP0008877_abnormal_DNA_methylation1.94053234
20MP0002064_seizures1.91931788
21MP0002734_abnormal_mechanical_nocicepti1.91736208
22MP0002063_abnormal_learning/memory/cond1.86922338
23MP0006072_abnormal_retinal_apoptosis1.86705079
24MP0001984_abnormal_olfaction1.86397588
25MP0001485_abnormal_pinna_reflex1.82940406
26MP0002272_abnormal_nervous_system1.82335372
27MP0000462_abnormal_digestive_system1.80727642
28MP0005423_abnormal_somatic_nervous1.79854020
29MP0005410_abnormal_fertilization1.79033478
30MP0002572_abnormal_emotion/affect_behav1.78496315
31MP0003172_abnormal_lysosome_physiology1.77789195
32MP0004742_abnormal_vestibular_system1.77447189
33MP0004924_abnormal_behavior1.75323235
34MP0005386_behavior/neurological_phenoty1.75323235
35MP0002638_abnormal_pupillary_reflex1.70416590
36MP0003656_abnormal_erythrocyte_physiolo1.68920588
37MP0005451_abnormal_body_composition1.67707104
38MP0009745_abnormal_behavioral_response1.66935098
39MP0000569_abnormal_digit_pigmentation1.64687836
40MP0003937_abnormal_limbs/digits/tail_de1.64382800
41MP0005379_endocrine/exocrine_gland_phen1.61334225
42MP0010386_abnormal_urinary_bladder1.58646986
43MP0003632_abnormal_nervous_system1.55047945
44MP0005645_abnormal_hypothalamus_physiol1.54983167
45MP0001299_abnormal_eye_distance/1.54447066
46MP0005171_absent_coat_pigmentation1.51718506
47MP0003221_abnormal_cardiomyocyte_apopto1.51582024
48MP0003787_abnormal_imprinting1.51351585
49MP0003724_increased_susceptibility_to1.50538951
50MP0004510_myositis1.50198761
51MP0009780_abnormal_chondrocyte_physiolo1.48950279
52MP0005075_abnormal_melanosome_morpholog1.47696049
53MP0002877_abnormal_melanocyte_morpholog1.47245260
54MP0003633_abnormal_nervous_system1.46471511
55MP0002067_abnormal_sensory_capabilities1.46381047
56MP0006054_spinal_hemorrhage1.45433343
57MP0002882_abnormal_neuron_morphology1.41838966
58* MP0003861_abnormal_nervous_system1.41165381
59MP0006276_abnormal_autonomic_nervous1.41066911
60MP0005623_abnormal_meninges_morphology1.40886626
61MP0009046_muscle_twitch1.40347566
62MP0002184_abnormal_innervation1.38757091
63MP0000955_abnormal_spinal_cord1.36867530
64MP0000537_abnormal_urethra_morphology1.36185571
65* MP0002152_abnormal_brain_morphology1.35761876
66MP0003718_maternal_effect1.35305294
67MP0003634_abnormal_glial_cell1.35218550
68MP0002163_abnormal_gland_morphology1.34625918
69MP0003121_genomic_imprinting1.34608276
70MP0000015_abnormal_ear_pigmentation1.34524208
71MP0002876_abnormal_thyroid_physiology1.33093314
72MP0002837_dystrophic_cardiac_calcinosis1.33065790
73MP0001440_abnormal_grooming_behavior1.32580920
74MP0004233_abnormal_muscle_weight1.32143561
75MP0002229_neurodegeneration1.30958417
76MP0002693_abnormal_pancreas_physiology1.30510233
77MP0005551_abnormal_eye_electrophysiolog1.30348985
78MP0001968_abnormal_touch/_nociception1.28570528
79MP0000427_abnormal_hair_cycle1.28502590
80MP0000013_abnormal_adipose_tissue1.28028717
81MP0001501_abnormal_sleep_pattern1.24829507
82MP0003938_abnormal_ear_development1.21876445
83MP0001346_abnormal_lacrimal_gland1.21513273
84MP0004885_abnormal_endolymph1.21237097
85MP0003045_fibrosis1.21077969
86MP0002752_abnormal_somatic_nervous1.20607586
87MP0002736_abnormal_nociception_after1.19594600
88MP0004484_altered_response_of1.18574710
89MP0004134_abnormal_chest_morphology1.17176125
90MP0001944_abnormal_pancreas_morphology1.15367914
91* MP0002066_abnormal_motor_capabilities/c1.13681435
92MP0005408_hypopigmentation1.13647390
93MP0005220_abnormal_exocrine_pancreas1.13183832
94MP0002090_abnormal_vision1.11787457
95MP0002102_abnormal_ear_morphology1.10974932
96MP0004215_abnormal_myocardial_fiber1.10368574
97MP0008569_lethality_at_weaning1.08386251
98MP0002751_abnormal_autonomic_nervous1.07359899
99MP0002332_abnormal_exercise_endurance1.06286446
100MP0008057_abnormal_DNA_replication1.05223766
101MP0005195_abnormal_posterior_eye1.03740814
102MP0000371_diluted_coat_color1.02738548
103MP0003698_abnormal_male_reproductive1.02276568
104MP0005535_abnormal_body_temperature1.01098139
105MP0001963_abnormal_hearing_physiology1.00593222
106MP0003868_abnormal_feces_composition1.00151358
107MP0003631_nervous_system_phenotype0.98203387
108MP0001929_abnormal_gametogenesis0.97984873
109* MP0004811_abnormal_neuron_physiology0.97779831
110MP0001727_abnormal_embryo_implantation0.96946629
111MP0005187_abnormal_penis_morphology0.96646881
112MP0004142_abnormal_muscle_tone0.95791779
113MP0005367_renal/urinary_system_phenotyp0.95709385
114MP0000516_abnormal_urinary_system0.95709385
115MP0003119_abnormal_digestive_system0.94974665
116MP0004185_abnormal_adipocyte_glucose0.94561596
117MP0004043_abnormal_pH_regulation0.94214513
118MP0000631_abnormal_neuroendocrine_gland0.93010212
119MP0003690_abnormal_glial_cell0.92239011
120MP0003122_maternal_imprinting0.90559165
121MP0002557_abnormal_social/conspecific_i0.90246121
122MP0000465_gastrointestinal_hemorrhage0.90014921
123MP0002735_abnormal_chemical_nociception0.89767965
124MP0002078_abnormal_glucose_homeostasis0.89319851
125MP0008789_abnormal_olfactory_epithelium0.89055265
126MP0009785_altered_susceptibility_to0.88000756
127MP0000372_irregular_coat_pigmentation0.86456570
128MP0005084_abnormal_gallbladder_morpholo0.86186832
129MP0003385_abnormal_body_wall0.85957265
130MP0001970_abnormal_pain_threshold0.85694740
131MP0000026_abnormal_inner_ear0.83837998
132MP0003183_abnormal_peptide_metabolism0.83558717
133* MP0002161_abnormal_fertility/fecundity0.83414134
134MP0001340_abnormal_eyelid_morphology0.81595712
135MP0005248_abnormal_Harderian_gland0.80971100
136MP0003890_abnormal_embryonic-extraembry0.80624855
137MP0005253_abnormal_eye_physiology0.80039773
138MP0002733_abnormal_thermal_nociception0.79470445
139MP0002928_abnormal_bile_duct0.79410826
140MP0010678_abnormal_skin_adnexa0.79090011
141MP0009250_abnormal_appendicular_skeleto0.75342153
142MP0005257_abnormal_intraocular_pressure0.73150377
143MP0002139_abnormal_hepatobiliary_system0.71319375
144MP0002084_abnormal_developmental_patter0.70765474
145MP0001835_abnormal_antigen_presentation0.69448845
146MP0000604_amyloidosis0.68022748
147MP0001730_embryonic_growth_arrest0.66154313
148MP0005394_taste/olfaction_phenotype0.65642454
149MP0005499_abnormal_olfactory_system0.65642454
150MP0001188_hyperpigmentation0.65329347
151* MP0002085_abnormal_embryonic_tissue0.63770763

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.87949774
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.87949774
3Insidious onset (HP:0003587)4.82198879
4Termporal pattern (HP:0011008)4.82198879
5Abnormality of the corticospinal tract (HP:0002492)4.54531262
6Cerebral inclusion bodies (HP:0100314)4.16530844
7Sensory axonal neuropathy (HP:0003390)4.05110631
8Neurofibrillary tangles (HP:0002185)3.97922565
9Hyperinsulinemic hypoglycemia (HP:0000825)3.97876452
10Ketoacidosis (HP:0001993)3.67484613
11Increased serum pyruvate (HP:0003542)3.58532722
12Abnormality of glycolysis (HP:0004366)3.58532722
13Hypoglycemic seizures (HP:0002173)3.48329899
14Small epiphyses (HP:0010585)3.31076737
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.20812856
16Thyroid carcinoma (HP:0002890)3.08725025
17EEG with generalized epileptiform discharges (HP:0011198)3.01090940
18Hypoglycemic coma (HP:0001325)2.98507053
19Papillary thyroid carcinoma (HP:0002895)2.95949533
20Hyperglycemia (HP:0003074)2.95132525
21Epileptiform EEG discharges (HP:0011182)2.93744309
22Hypsarrhythmia (HP:0002521)2.92087156
23Intention tremor (HP:0002080)2.89912742
24Absent speech (HP:0001344)2.89714856
25Abnormality of the labia minora (HP:0012880)2.89040777
26Akinesia (HP:0002304)2.88751256
27Symptomatic seizures (HP:0011145)2.85350102
28Abnormality of endocrine pancreas physiology (HP:0012093)2.76693530
29Abnormality of the pancreatic islet cells (HP:0006476)2.76693530
30Progressive cerebellar ataxia (HP:0002073)2.74487879
31Curly hair (HP:0002212)2.72291437
32Febrile seizures (HP:0002373)2.70481138
33Scanning speech (HP:0002168)2.67379383
34Peripheral hypomyelination (HP:0007182)2.57440554
35Gaze-evoked nystagmus (HP:0000640)2.53127572
36Ankyloglossia (HP:0010296)2.51208364
37Parakeratosis (HP:0001036)2.50402815
38Hypothermia (HP:0002045)2.49111114
39Prominent metopic ridge (HP:0005487)2.48636851
40Spastic gait (HP:0002064)2.48012602
41Increased hepatocellular lipid droplets (HP:0006565)2.44447352
42Metaphyseal dysplasia (HP:0100255)2.43933304
43Agitation (HP:0000713)2.43273268
44Fair hair (HP:0002286)2.39006812
45Dysdiadochokinesis (HP:0002075)2.38535650
46Supranuclear gaze palsy (HP:0000605)2.38431826
47Generalized hypopigmentation of hair (HP:0011358)2.37412912
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33064765
49Leukodystrophy (HP:0002415)2.32612687
50Morphological abnormality of the pyramidal tract (HP:0002062)2.29956786
51Postural tremor (HP:0002174)2.29626547
52Atonic seizures (HP:0010819)2.28928425
53Abnormality of B cell number (HP:0010975)2.26500759
54B lymphocytopenia (HP:0010976)2.26500759
55Methylmalonic acidemia (HP:0002912)2.25206443
56Alacrima (HP:0000522)2.23478151
57Insulin-resistant diabetes mellitus (HP:0000831)2.20978335
58Renal cortical cysts (HP:0000803)2.19255553
59Bundle branch block (HP:0011710)2.18936161
60Myokymia (HP:0002411)2.17705207
61Impaired vibratory sensation (HP:0002495)2.15011705
62Abnormality of the metopic suture (HP:0005556)2.14931351
63Hyperventilation (HP:0002883)2.14706934
64Delayed epiphyseal ossification (HP:0002663)2.14687867
65Large for gestational age (HP:0001520)2.14677755
66Generalized myoclonic seizures (HP:0002123)2.14584604
67Dysmetria (HP:0001310)2.13200507
68Bowel incontinence (HP:0002607)2.13138291
69Autoamputation (HP:0001218)2.12243041
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.12141890
71Absent/shortened dynein arms (HP:0200106)2.12141890
72Truncal ataxia (HP:0002078)2.11544431
73Epileptic encephalopathy (HP:0200134)2.11412788
74Dysmetric saccades (HP:0000641)2.10483704
75Acute necrotizing encephalopathy (HP:0006965)2.08925689
76Congenital primary aphakia (HP:0007707)2.08777695
77Muscle hypertrophy of the lower extremities (HP:0008968)2.08518472
78Abnormal biliary tract morphology (HP:0012440)2.07558240
79Urinary urgency (HP:0000012)2.07076834
80Oligodactyly (hands) (HP:0001180)2.07064193
81Medial flaring of the eyebrow (HP:0010747)2.06572551
82Cerebral hypomyelination (HP:0006808)2.04558352
83Muscular hypotonia of the trunk (HP:0008936)2.03870929
84Limb dystonia (HP:0002451)2.03193916
85Progressive macrocephaly (HP:0004481)2.02843971
86Proximal tubulopathy (HP:0000114)2.02796944
87Abnormal hair whorl (HP:0010721)2.02103137
88Pheochromocytoma (HP:0002666)2.01371900
89Tetraparesis (HP:0002273)2.00947874
90Horizontal nystagmus (HP:0000666)1.99380501
91Gait ataxia (HP:0002066)1.98650392
92Cerebral hemorrhage (HP:0001342)1.98520774
93Pancreatic islet-cell hyperplasia (HP:0004510)1.98397867
94Dialeptic seizures (HP:0011146)1.98355024
95Lipid accumulation in hepatocytes (HP:0006561)1.95783526
96Nephrogenic diabetes insipidus (HP:0009806)1.94599525
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94476388
98Ketosis (HP:0001946)1.94453945
99Partial agenesis of the corpus callosum (HP:0001338)1.94422171
100Thickened helices (HP:0000391)1.94402099
101Ankle clonus (HP:0011448)1.93706302
102Cortical dysplasia (HP:0002539)1.93610694
103* Thyroiditis (HP:0100646)1.93450359
104Intestinal atresia (HP:0011100)1.93383414
105Abnormal large intestine physiology (HP:0012700)1.92399619
106Drooling (HP:0002307)1.89439370
107Excessive salivation (HP:0003781)1.89439370
108Abnormality of glycolipid metabolism (HP:0010969)1.87878005
109Abnormality of liposaccharide metabolism (HP:0010968)1.87878005
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.87878005
111Action tremor (HP:0002345)1.86663367
112Adrenal hypoplasia (HP:0000835)1.84428087
113Focal seizures (HP:0007359)1.84258366
114Paraplegia (HP:0010550)1.83919463
115Abnormality of the musculature of the pelvis (HP:0001469)1.82527905
116Abnormality of the hip-girdle musculature (HP:0001445)1.82527905
117Large earlobe (HP:0009748)1.81891641
118Delayed gross motor development (HP:0002194)1.81847402
119Spastic tetraplegia (HP:0002510)1.81552882
120Blue irides (HP:0000635)1.81499794
121Widely spaced teeth (HP:0000687)1.81108597
122Hemiparesis (HP:0001269)1.80761542
123Fetal akinesia sequence (HP:0001989)1.80244752
124Chin dimple (HP:0010751)1.78739724
125Bladder carcinoma (HP:0002862)1.78412318
126Bladder neoplasm (HP:0009725)1.78412318
127T lymphocytopenia (HP:0005403)1.77857977
128Cupped ear (HP:0000378)1.77711635
129Urinary bladder sphincter dysfunction (HP:0002839)1.76980414
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76805201
131Broad-based gait (HP:0002136)1.76743108
132Amyotrophic lateral sclerosis (HP:0007354)1.76278626
133Transitional cell carcinoma of the bladder (HP:0006740)1.75281077
134Biliary tract neoplasm (HP:0100574)1.74839282
135Hypophosphatemic rickets (HP:0004912)1.74592161
136Hematochezia (HP:0002573)1.73942100
137Erythroderma (HP:0001019)1.73712620
138Abnormality of oral frenula (HP:0000190)1.73439900
139Depression (HP:0000716)1.73415285
140Impaired vibration sensation in the lower limbs (HP:0002166)1.73272041
141Focal motor seizures (HP:0011153)1.73026488
142Abnormality of calcium-phosphate metabolism (HP:0100530)1.72859406
143Lower limb muscle weakness (HP:0007340)1.72402461
144Fibular aplasia (HP:0002990)1.72146258
145Abnormality of the periventricular white matter (HP:0002518)1.71397440
146Cutaneous melanoma (HP:0012056)1.70602596
147Neuroendocrine neoplasm (HP:0100634)1.70597547
148Renal Fanconi syndrome (HP:0001994)1.70296031
149Menstrual irregularities (HP:0000858)1.69932992
150Anteriorly placed anus (HP:0001545)1.68971176
151Clonus (HP:0002169)1.68969516
152Abnormal auditory evoked potentials (HP:0006958)1.68627816
153Truncus arteriosus (HP:0001660)1.67055340
154Abnormality of placental membranes (HP:0011409)1.66180417
155Amniotic constriction ring (HP:0009775)1.66180417
156Diminished movement (HP:0002374)1.65950647
157Buphthalmos (HP:0000557)1.65755999
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64990125
159Absent epiphyses (HP:0010577)1.64990125
160Decreased lacrimation (HP:0000633)1.64700564
161Abnormality of the parathyroid morphology (HP:0011766)1.64574617
162Abnormality of macular pigmentation (HP:0008002)1.63709688
163Choroideremia (HP:0001139)1.63685579
164Megalencephaly (HP:0001355)1.63592756
165Gastroesophageal reflux (HP:0002020)1.61103265
166Genital tract atresia (HP:0001827)1.59992270
167Abnormal mitochondria in muscle tissue (HP:0008316)1.59015018
168Hypoplastic pelvis (HP:0008839)1.58394011
169Acute encephalopathy (HP:0006846)1.57436195
170Stenosis of the external auditory canal (HP:0000402)1.55640947
171Vertebral arch anomaly (HP:0008438)1.54108912
172Gait imbalance (HP:0002141)1.54097488
173Visual hallucinations (HP:0002367)1.53813715
174Delusions (HP:0000746)1.52348914
175Barrel-shaped chest (HP:0001552)1.51864382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.93752423
2STK393.77911125
3FRK3.63704796
4OXSR12.83905577
5CASK2.72959133
6MST42.49412578
7MAP3K42.42064246
8TRIM282.34980221
9ERBB32.33696950
10EPHB12.14171471
11CAMKK22.13123540
12MARK12.05684037
13TRPM72.04249544
14AKT32.03851257
15PLK21.89215174
16BMPR21.81299215
17MAP2K71.80951152
18LIMK11.80488061
19PDK21.78909731
20SIK31.67481000
21CSNK1G31.62656089
22FGR1.59768222
23CSNK1G21.53352640
24WNK41.51684937
25MAPK131.51450572
26CDK191.50785989
27BCR1.49038883
28LATS11.48495210
29EPHA41.38315225
30GRK71.38143146
31ACVR1B1.38134081
32BMPR1B1.37786467
33TYRO31.37735666
34UHMK11.36520574
35FER1.32332259
36CSNK1G11.32255284
37CDK81.31249929
38DYRK21.30423264
39CSNK1A1L1.29841529
40NTRK31.28757544
41PAK61.28531940
42LATS21.27303930
43GRK61.20517423
44MAP4K21.20374179
45CDK141.19231776
46ROCK21.18319665
47PKN11.17005311
48MAP3K141.16272420
49NTRK21.15089059
50FGFR21.14865703
51PAK31.14374121
52DAPK21.12511753
53MKNK21.12318437
54MAP3K121.12299049
55PINK11.11101629
56FGFR31.09730639
57NUAK11.08461668
58ICK1.06888627
59CDC71.05835196
60MELK1.05099780
61SGK21.03538830
62ERBB41.02707432
63PTK2B1.01692738
64PBK1.00025190
65CDK150.98863203
66MAP3K100.96679946
67CDK180.95760348
68CAMK2B0.94265961
69CAMK2A0.89820182
70MAP3K90.89247557
71EPHA30.87946619
72MAP3K50.87566345
73CSNK1D0.87448857
74MAP2K40.86837534
75SGK30.84937071
76CDK11A0.83213449
77MARK20.82724881
78SIK20.82018004
79MAP3K60.81990563
80CDK50.81717764
81JAK10.81324381
82TXK0.81244788
83MAP3K20.80140470
84MET0.79556170
85TNIK0.78894518
86TAOK10.78412149
87STK38L0.78172736
88MINK10.77172019
89IRAK10.76849646
90RIPK40.75238260
91PLK30.74155213
92NTRK10.73972169
93WNK10.72543448
94PRKCE0.72008027
95PDK10.70459826
96MKNK10.70403946
97DYRK30.69760139
98TTK0.68062553
99STK240.67474768
100PIK3CA0.67155129
101SGK2230.66033125
102SGK4940.66033125
103CDK90.65501758
104PRKCQ0.65088392
105STK100.63019734
106SCYL20.62678009
107MATK0.62182639
108STK30.62136789
109PHKG20.61879882
110PHKG10.61879882
111CAMK2D0.60181709
112CDK120.58525413
113CLK10.57711027
114PRKAA10.57189331
115CHEK20.56878188
116EIF2AK30.56817545
117SYK0.56654727
118PDK40.56592775
119PDK30.56592775
120TYK20.56382929
121RET0.55556267
122CAMK1G0.54328611
123CAMKK10.54267484
124GRK50.54045287
125CSNK1E0.52521581
126PASK0.52268500
127EGFR0.50987720
128KSR20.50291041
129TAOK30.49319153
130NEK60.49182959
131WNK30.49002292
132OBSCN0.48801775
133ABL10.48649515
134MOS0.48559279
135PRKG10.47983746
136NLK0.47379197
137DYRK1A0.46683505
138PDGFRB0.46287855
139BRD40.45552788
140SRPK10.45091199
141IKBKE0.44953579
142STK380.44334414
143PRKAA20.44267874
144JAK20.43894324
145CAMK40.43864036
146NEK90.43548093
147ALK0.42860722
148MAPK120.42758399
149MAP3K70.42073779
150YES10.42047537
151BUB10.42013612
152STK110.41626387
153HCK0.41321446
154MAPK100.40618775
155KSR10.40108361
156PRKCG0.39176329

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.69016478
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.12176180
3Steroid biosynthesis_Homo sapiens_hsa001002.84546887
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.65413773
5Oxidative phosphorylation_Homo sapiens_hsa001902.29194480
6Axon guidance_Homo sapiens_hsa043602.21276270
7Nicotine addiction_Homo sapiens_hsa050331.94651057
8Alzheimers disease_Homo sapiens_hsa050101.90738265
9Long-term depression_Homo sapiens_hsa047301.90130544
10Ether lipid metabolism_Homo sapiens_hsa005651.89704021
11Long-term potentiation_Homo sapiens_hsa047201.86269578
12Renal cell carcinoma_Homo sapiens_hsa052111.85767437
13Dopaminergic synapse_Homo sapiens_hsa047281.83403075
14Dorso-ventral axis formation_Homo sapiens_hsa043201.81960640
15Parkinsons disease_Homo sapiens_hsa050121.77824614
16Glutamatergic synapse_Homo sapiens_hsa047241.74205755
17Serotonergic synapse_Homo sapiens_hsa047261.69721936
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66405057
19Amphetamine addiction_Homo sapiens_hsa050311.54605458
20Oocyte meiosis_Homo sapiens_hsa041141.51687222
21Circadian rhythm_Homo sapiens_hsa047101.43311630
22Cardiac muscle contraction_Homo sapiens_hsa042601.42892012
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41031483
24Huntingtons disease_Homo sapiens_hsa050161.40557581
25GABAergic synapse_Homo sapiens_hsa047271.36369858
26Fatty acid elongation_Homo sapiens_hsa000621.33816226
27ErbB signaling pathway_Homo sapiens_hsa040121.31562206
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29768396
29Collecting duct acid secretion_Homo sapiens_hsa049661.24117318
30Legionellosis_Homo sapiens_hsa051341.22077391
31Cholinergic synapse_Homo sapiens_hsa047251.20879597
32mTOR signaling pathway_Homo sapiens_hsa041501.20097796
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17891182
34Basal transcription factors_Homo sapiens_hsa030221.17208280
35Butanoate metabolism_Homo sapiens_hsa006501.17131420
36Morphine addiction_Homo sapiens_hsa050321.14850858
37Cocaine addiction_Homo sapiens_hsa050301.13972889
38Synaptic vesicle cycle_Homo sapiens_hsa047211.13867077
39Renin secretion_Homo sapiens_hsa049241.11755432
40Circadian entrainment_Homo sapiens_hsa047131.11229361
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06978737
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04688685
43mRNA surveillance pathway_Homo sapiens_hsa030151.04142005
44Type I diabetes mellitus_Homo sapiens_hsa049401.03348553
45Regulation of autophagy_Homo sapiens_hsa041401.03210878
46Choline metabolism in cancer_Homo sapiens_hsa052311.02364337
47Phagosome_Homo sapiens_hsa041450.99518859
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98984279
49Prolactin signaling pathway_Homo sapiens_hsa049170.96566642
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93670089
51Inositol phosphate metabolism_Homo sapiens_hsa005620.93627765
52Rheumatoid arthritis_Homo sapiens_hsa053230.93255505
53Oxytocin signaling pathway_Homo sapiens_hsa049210.93169495
54Vibrio cholerae infection_Homo sapiens_hsa051100.93141902
55Insulin secretion_Homo sapiens_hsa049110.92920202
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92171441
57Salivary secretion_Homo sapiens_hsa049700.91684993
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91341832
59Gap junction_Homo sapiens_hsa045400.91312966
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90165592
61GnRH signaling pathway_Homo sapiens_hsa049120.89251569
62Sulfur metabolism_Homo sapiens_hsa009200.88265753
63Estrogen signaling pathway_Homo sapiens_hsa049150.88011621
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87774439
65Glioma_Homo sapiens_hsa052140.87758758
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86235614
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84426916
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84104977
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83691751
70Tuberculosis_Homo sapiens_hsa051520.83060270
71Alcoholism_Homo sapiens_hsa050340.82656419
72Ras signaling pathway_Homo sapiens_hsa040140.82635594
73Melanogenesis_Homo sapiens_hsa049160.81797300
74Gastric acid secretion_Homo sapiens_hsa049710.81041497
75Tight junction_Homo sapiens_hsa045300.79862241
76African trypanosomiasis_Homo sapiens_hsa051430.79822768
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78922906
78TGF-beta signaling pathway_Homo sapiens_hsa043500.77996809
79Lysosome_Homo sapiens_hsa041420.77026829
80Fatty acid biosynthesis_Homo sapiens_hsa000610.76370987
81Endometrial cancer_Homo sapiens_hsa052130.73759014
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.73210371
83RNA polymerase_Homo sapiens_hsa030200.72599339
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72355392
85MAPK signaling pathway_Homo sapiens_hsa040100.71287961
86Insulin signaling pathway_Homo sapiens_hsa049100.71013043
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.69513265
88RNA degradation_Homo sapiens_hsa030180.69451782
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.69393997
90Taste transduction_Homo sapiens_hsa047420.69222116
91Hippo signaling pathway_Homo sapiens_hsa043900.68584711
92Phototransduction_Homo sapiens_hsa047440.68135911
93Salmonella infection_Homo sapiens_hsa051320.67791682
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.66148404
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65670796
96B cell receptor signaling pathway_Homo sapiens_hsa046620.64532337
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64268356
98MicroRNAs in cancer_Homo sapiens_hsa052060.63938261
99FoxO signaling pathway_Homo sapiens_hsa040680.63683529
100Colorectal cancer_Homo sapiens_hsa052100.62836050
101Linoleic acid metabolism_Homo sapiens_hsa005910.62624456
102Prostate cancer_Homo sapiens_hsa052150.61655538
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61396695
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61319173
105Pyruvate metabolism_Homo sapiens_hsa006200.61110817
106Primary immunodeficiency_Homo sapiens_hsa053400.60102965
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.60062099
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59763709
109Hedgehog signaling pathway_Homo sapiens_hsa043400.59261801
110Glucagon signaling pathway_Homo sapiens_hsa049220.58955283
111cAMP signaling pathway_Homo sapiens_hsa040240.58945933
112Chemokine signaling pathway_Homo sapiens_hsa040620.58830776
113Cell cycle_Homo sapiens_hsa041100.58736928
114Pancreatic cancer_Homo sapiens_hsa052120.57397869
115Ovarian steroidogenesis_Homo sapiens_hsa049130.57035966
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.56960313
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56942846
118Wnt signaling pathway_Homo sapiens_hsa043100.56847425
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56449873
120Protein export_Homo sapiens_hsa030600.55713484
121Osteoclast differentiation_Homo sapiens_hsa043800.54570972
122Pertussis_Homo sapiens_hsa051330.53567784
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53532149
124Other glycan degradation_Homo sapiens_hsa005110.52992371
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52631680
126ABC transporters_Homo sapiens_hsa020100.52578969
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52338993
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52108499
129Insulin resistance_Homo sapiens_hsa049310.51702241
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51466972
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51367478
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51199503
133* Non-homologous end-joining_Homo sapiens_hsa034500.50179236
134Sphingolipid metabolism_Homo sapiens_hsa006000.49834909
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49556252
136Olfactory transduction_Homo sapiens_hsa047400.49445287
137Calcium signaling pathway_Homo sapiens_hsa040200.45572521
138T cell receptor signaling pathway_Homo sapiens_hsa046600.45538176
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44640700
140Measles_Homo sapiens_hsa051620.43534799
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42994274
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42380613
143Amoebiasis_Homo sapiens_hsa051460.42338408
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.42034674
145Type II diabetes mellitus_Homo sapiens_hsa049300.41585812
146Non-small cell lung cancer_Homo sapiens_hsa052230.40846450

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