LILRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.34808022
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.34808022
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.29635806
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.29635806
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.29635806
6modulation by symbiont of host immune response (GO:0052553)6.29635806
7positive regulation by symbiont of host defense response (GO:0052509)6.29635806
8modulation by symbiont of host defense response (GO:0052031)6.29635806
9positive regulation of gamma-delta T cell activation (GO:0046645)6.24767425
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.08557292
11neutrophil activation involved in immune response (GO:0002283)5.87273956
12response to peptidoglycan (GO:0032494)5.40846512
13macrophage activation involved in immune response (GO:0002281)5.28980250
14detection of other organism (GO:0098543)5.28740701
15antigen processing and presentation of endogenous antigen (GO:0019883)5.10950583
16detection of bacterium (GO:0016045)4.95715957
17regulation of B cell receptor signaling pathway (GO:0050855)4.92425070
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.88772393
19cellular extravasation (GO:0045123)4.84619820
20detection of molecule of bacterial origin (GO:0032490)4.80322140
21negative regulation of interleukin-12 production (GO:0032695)4.76665488
22detection of external biotic stimulus (GO:0098581)4.60811487
23microglial cell activation (GO:0001774)4.51184430
24regulation of gamma-delta T cell activation (GO:0046643)4.47833316
25neutrophil activation (GO:0042119)4.46926174
26leukocyte aggregation (GO:0070486)4.41502372
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.39070639
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.35980378
29regulation of interferon-beta biosynthetic process (GO:0045357)4.27470809
30respiratory burst (GO:0045730)4.27323863
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.24651448
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.24617719
33response to host immune response (GO:0052572)4.24617719
34detection of biotic stimulus (GO:0009595)4.13930805
35immunoglobulin mediated immune response (GO:0016064)4.12469418
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08584380
37positive regulation of mast cell activation (GO:0033005)4.07441770
38granulocyte activation (GO:0036230)4.03969852
39macrophage activation (GO:0042116)4.03431364
40regulation of mast cell degranulation (GO:0043304)4.01243947
41leukocyte migration involved in inflammatory response (GO:0002523)4.00617240
42myeloid cell activation involved in immune response (GO:0002275)3.99785018
43neutrophil mediated immunity (GO:0002446)3.98130142
44negative regulation of T cell mediated immunity (GO:0002710)3.95743421
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.90896427
46response to host (GO:0075136)3.90896427
47response to host defenses (GO:0052200)3.90896427
48negative regulation of leukocyte mediated immunity (GO:0002704)3.74604737
49regulation of mast cell activation involved in immune response (GO:0033006)3.71065973
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.70778037
51antigen processing and presentation via MHC class Ib (GO:0002475)3.70612089
52positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.67555738
53regulation of gamma-delta T cell differentiation (GO:0045586)3.64874346
54regulation of mast cell activation (GO:0033003)3.63959378
55response to interleukin-15 (GO:0070672)3.60106816
56regulation of leukocyte degranulation (GO:0043300)3.54620495
57regulation of tolerance induction (GO:0002643)3.54294308
58positive regulation of mast cell degranulation (GO:0043306)3.47478403
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.47478403
60response to muramyl dipeptide (GO:0032495)3.45429435
61production of molecular mediator involved in inflammatory response (GO:0002532)3.44708611
62regulation of T cell tolerance induction (GO:0002664)3.42960633
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38750489
64B cell receptor signaling pathway (GO:0050853)3.37926663
65myeloid leukocyte mediated immunity (GO:0002444)3.35561289
66leukocyte degranulation (GO:0043299)3.28806885
67negative regulation of erythrocyte differentiation (GO:0045647)3.28584948
68B cell mediated immunity (GO:0019724)3.27642825
69cellular response to interleukin-15 (GO:0071350)3.25493260
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25166919
71regulation of B cell differentiation (GO:0045577)3.25104332
72defense response to protozoan (GO:0042832)3.20580506
73positive regulation of B cell differentiation (GO:0045579)3.17292208
74lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15961512
75positive regulation of cellular amide metabolic process (GO:0034250)3.11343466
76regulation of regulated secretory pathway (GO:1903305)3.10877269
77regulation of T-helper 2 cell differentiation (GO:0045628)3.09291391
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07754373
79cellular response to type I interferon (GO:0071357)3.07740426
80type I interferon signaling pathway (GO:0060337)3.07740426
81activated T cell proliferation (GO:0050798)3.05814194
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05406347
83interferon-gamma-mediated signaling pathway (GO:0060333)3.05125083
84response to type I interferon (GO:0034340)3.05118072
85positive regulation of tolerance induction (GO:0002645)3.03215164
86negative thymic T cell selection (GO:0045060)3.02703191
87dendritic cell migration (GO:0036336)2.99736526
88positive thymic T cell selection (GO:0045059)2.98914604
89positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97332918
90myeloid leukocyte activation (GO:0002274)2.97105309
91regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97100097
92negative regulation of cytokine production involved in immune response (GO:0002719)2.95290297
93negative regulation of interleukin-6 production (GO:0032715)2.94398807
94germinal center formation (GO:0002467)2.94288817
95negative regulation of type 2 immune response (GO:0002829)2.93664578
96T cell migration (GO:0072678)2.93535567
97negative T cell selection (GO:0043383)2.93451367
98regulation of alpha-beta T cell proliferation (GO:0046640)2.91848799
99positive regulation of interferon-alpha production (GO:0032727)2.89467115
100neutrophil chemotaxis (GO:0030593)2.89417089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.45653044
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.92307167
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.40751179
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.89327243
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.87171982
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.62566724
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44461075
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.37988427
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01575472
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96435213
11SPI1_23547873_ChIP-Seq_NB4_Human2.89123510
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88387316
13RUNX_20019798_ChIP-Seq_JUKART_Human2.74917077
14SPI1_23127762_ChIP-Seq_K562_Human2.74754995
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68184448
16VDR_24763502_ChIP-Seq_THP-1_Human2.67829667
17VDR_21846776_ChIP-Seq_THP-1_Human2.65187573
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63155191
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57339989
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49258861
21SCL_19346495_ChIP-Seq_HPC-7_Human2.48651375
22MYB_26560356_Chip-Seq_TH2_Human2.33075837
23MAF_26560356_Chip-Seq_TH1_Human2.32531810
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.32256918
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25747799
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23859472
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22595178
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19273010
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16770508
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.12229970
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09381008
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08838646
33UTX_26944678_Chip-Seq_JUKART_Human2.07229097
34MYC_22102868_ChIP-Seq_BL_Human2.01090586
35MYB_26560356_Chip-Seq_TH1_Human1.98721680
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92628445
37TCF7_22412390_ChIP-Seq_EML_Mouse1.88653654
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87825717
39VDR_24787735_ChIP-Seq_THP-1_Human1.86728218
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82695458
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.80579656
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72713051
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70632663
44GATA3_27048872_Chip-Seq_THYMUS_Human1.67758271
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66529273
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63974299
47MAF_26560356_Chip-Seq_TH2_Human1.63660726
48KDM2B_26808549_Chip-Seq_DND41_Human1.60868669
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.60765866
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51099203
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50557673
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49954982
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44930848
54PU_27001747_Chip-Seq_BMDM_Mouse1.43073645
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43025775
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42237556
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41272565
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40816018
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39379718
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38588402
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37807630
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37560504
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37048344
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35812328
65GATA3_26560356_Chip-Seq_TH2_Human1.34074007
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31724281
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31722064
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30984526
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30272647
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27508337
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26194268
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24968606
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24653370
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19954716
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19670242
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18310163
77GATA1_19941826_ChIP-Seq_K562_Human1.15226426
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.15007889
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.11026931
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07141013
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.06040767
82GATA1_22025678_ChIP-Seq_K562_Human1.05794708
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05752404
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05357704
85ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98144835
86LXR_22292898_ChIP-Seq_THP-1_Human0.97577372
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97324830
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96365901
89GATA2_19941826_ChIP-Seq_K562_Human0.96334667
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95435582
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91637414
92* BCL6_27268052_Chip-Seq_Bcells_Human0.91301931
93BCOR_27268052_Chip-Seq_Bcells_Human0.85294693
94GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83737930
95NCOR1_26117541_ChIP-Seq_K562_Human0.83551499
96SPI1_20517297_ChIP-Seq_HL60_Human0.83225952
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81333418
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78285493
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74302009
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73533563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.11537326
2MP0003436_decreased_susceptibility_to4.32270959
3MP0001835_abnormal_antigen_presentation4.13216909
4MP0003303_peritoneal_inflammation3.92290430
5MP0002419_abnormal_innate_immunity3.24462684
6MP0005671_abnormal_response_to2.99607522
7MP0009785_altered_susceptibility_to2.91504285
8MP0001800_abnormal_humoral_immune2.91423075
9MP0005025_abnormal_response_to2.90332266
10MP0005000_abnormal_immune_tolerance2.87251761
11MP0006082_CNS_inflammation2.87035880
12MP0000685_abnormal_immune_system2.77228082
13MP0001790_abnormal_immune_system2.73170883
14MP0005387_immune_system_phenotype2.73170883
15MP0002723_abnormal_immune_serum2.60345942
16MP0002452_abnormal_antigen_presenting2.53940997
17MP0002420_abnormal_adaptive_immunity2.52093139
18MP0001819_abnormal_immune_cell2.49676789
19MP0003300_gastrointestinal_ulcer2.40706339
20MP0005464_abnormal_platelet_physiology2.36283931
21MP0002148_abnormal_hypersensitivity_rea2.31389398
22MP0001533_abnormal_skeleton_physiology2.18252137
23MP0003191_abnormal_cellular_cholesterol2.16223678
24MP0003828_pulmonary_edema2.10573640
25MP0008260_abnormal_autophagy2.09437200
26MP0003763_abnormal_thymus_physiology1.97690284
27MP0002405_respiratory_system_inflammati1.96449797
28MP0002132_abnormal_respiratory_system1.93395469
29MP0003172_abnormal_lysosome_physiology1.91086903
30MP0002398_abnormal_bone_marrow1.90176198
31MP0000716_abnormal_immune_system1.86127274
32MP0010155_abnormal_intestine_physiology1.77748044
33MP0009278_abnormal_bone_marrow1.76931349
34MP0001845_abnormal_inflammatory_respons1.75867103
35MP0004947_skin_inflammation1.63678154
36MP0000465_gastrointestinal_hemorrhage1.59904176
37MP0009764_decreased_sensitivity_to1.58493373
38MP0000689_abnormal_spleen_morphology1.57867984
39MP0002722_abnormal_immune_system1.55161441
40MP0003866_abnormal_defecation1.54441571
41MP0009333_abnormal_splenocyte_physiolog1.53976462
42MP0004883_abnormal_blood_vessel1.53667853
43MP0002396_abnormal_hematopoietic_system1.49450335
44MP0003183_abnormal_peptide_metabolism1.48479466
45MP0002429_abnormal_blood_cell1.47128468
46MP0008469_abnormal_protein_level1.44809220
47MP0005451_abnormal_body_composition1.43180382
48MP0000858_altered_metastatic_potential1.40210166
49MP0003075_altered_response_to1.39063113
50MP0004381_abnormal_hair_follicle1.38799724
51MP0005397_hematopoietic_system_phenotyp1.37546703
52MP0001545_abnormal_hematopoietic_system1.37546703
53MP0000703_abnormal_thymus_morphology1.36175919
54MP0001851_eye_inflammation1.32627623
55MP0004510_myositis1.30960752
56MP0003690_abnormal_glial_cell1.30839273
57MP0005310_abnormal_salivary_gland1.30320524
58MP0002998_abnormal_bone_remodeling1.29394405
59MP0002277_abnormal_respiratory_mucosa1.26696303
60MP0008004_abnormal_stomach_pH1.20260997
61MP0002166_altered_tumor_susceptibility1.17534013
62MP0005058_abnormal_lysosome_morphology1.16533670
63MP0005164_abnormal_response_to1.16435941
64MP0005166_decreased_susceptibility_to1.10927672
65MP0000343_altered_response_to1.00108008
66MP0003448_altered_tumor_morphology0.93763832
67MP0001853_heart_inflammation0.92459713
68MP0009763_increased_sensitivity_to0.88616753
69MP0003656_abnormal_erythrocyte_physiolo0.85861799
70MP0005390_skeleton_phenotype0.85822881
71MP0001663_abnormal_digestive_system0.84912371
72MP0001986_abnormal_taste_sensitivity0.81972543
73MP0003806_abnormal_nucleotide_metabolis0.79951487
74MP0004808_abnormal_hematopoietic_stem0.78584404
75MP0005075_abnormal_melanosome_morpholog0.78494293
76MP0000569_abnormal_digit_pigmentation0.77462111
77MP0002006_tumorigenesis0.75765007
78MP0000015_abnormal_ear_pigmentation0.75011199
79MP0003045_fibrosis0.71771982
80MP0000604_amyloidosis0.70660184
81MP0009765_abnormal_xenobiotic_induced0.69472622
82MP0002009_preneoplasia0.68960612
83MP0000490_abnormal_crypts_of0.67101227
84MP0004130_abnormal_muscle_cell0.66086636
85MP0000249_abnormal_blood_vessel0.65845041
86MP0001873_stomach_inflammation0.64604515
87MP0003795_abnormal_bone_structure0.63944707
88MP0008874_decreased_physiological_sensi0.63145831
89MP0002332_abnormal_exercise_endurance0.62093560
90MP0003221_abnormal_cardiomyocyte_apopto0.59774040
91MP0005083_abnormal_biliary_tract0.58333582
92MP0003091_abnormal_cell_migration0.56773467
93MP0002933_joint_inflammation0.56115806
94MP0002133_abnormal_respiratory_system0.54185054
95MP0005388_respiratory_system_phenotype0.54185054
96MP0004484_altered_response_of0.52186753
97MP0002928_abnormal_bile_duct0.48776117
98MP0000920_abnormal_myelination0.48547863
99MP0005319_abnormal_enzyme/_coenzyme0.48158546
100MP0005076_abnormal_cell_differentiation0.47165497

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.85176036
2Recurrent bacterial skin infections (HP:0005406)6.39270111
3Recurrent abscess formation (HP:0002722)6.33954347
4Myositis (HP:0100614)6.00310003
5Orchitis (HP:0100796)5.70941536
6Abnormality of macrophages (HP:0004311)5.68998718
7Retrobulbar optic neuritis (HP:0100654)5.46983156
8Optic neuritis (HP:0100653)5.46983156
9Recurrent gram-negative bacterial infections (HP:0005420)5.24187331
10Stomatitis (HP:0010280)5.02803969
11Elevated erythrocyte sedimentation rate (HP:0003565)4.95608071
12Recurrent fungal infections (HP:0002841)4.34823112
13Gastrointestinal infarctions (HP:0005244)4.31424594
14Recurrent skin infections (HP:0001581)4.21123079
15Chronic obstructive pulmonary disease (HP:0006510)4.13809461
16Obstructive lung disease (HP:0006536)4.13809461
17Mediastinal lymphadenopathy (HP:0100721)4.04424078
18Meningitis (HP:0001287)3.97481481
19Keratoconjunctivitis sicca (HP:0001097)3.96396248
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.85481879
21Chronic mucocutaneous candidiasis (HP:0002728)3.81834563
22Recurrent cutaneous fungal infections (HP:0011370)3.81834563
23Encephalitis (HP:0002383)3.81715738
24Prolonged bleeding time (HP:0003010)3.76018666
25Spontaneous hematomas (HP:0007420)3.72990092
26Keratoconjunctivitis (HP:0001096)3.70402126
27Urticaria (HP:0001025)3.57064276
28Gingivitis (HP:0000230)3.55680208
29Vasculitis (HP:0002633)3.54697126
30Gingival bleeding (HP:0000225)3.39468122
31Chest pain (HP:0100749)3.37441509
32Increased IgE level (HP:0003212)3.37373655
33Episodic fever (HP:0001954)3.31308179
34Amyloidosis (HP:0011034)3.30644362
35Hypochromic microcytic anemia (HP:0004840)3.29508825
36Hemoptysis (HP:0002105)3.14749749
37Arterial thrombosis (HP:0004420)3.12123071
38Peritonitis (HP:0002586)3.07876027
39Cellulitis (HP:0100658)3.07222835
40Epistaxis (HP:0000421)3.06542604
41Pulmonary infiltrates (HP:0002113)3.03803371
42Leukocytosis (HP:0001974)3.02548745
43T lymphocytopenia (HP:0005403)3.01183078
44Hypochromic anemia (HP:0001931)2.91340922
45Abnormality of T cell number (HP:0011839)2.88183074
46Recurrent viral infections (HP:0004429)2.86753928
47Petechiae (HP:0000967)2.83275359
48Anorexia (HP:0002039)2.80358057
49Pulmonary embolism (HP:0002204)2.73748027
50Inflammation of the large intestine (HP:0002037)2.69000075
51Gastrointestinal inflammation (HP:0004386)2.58172314
52Panhypogammaglobulinemia (HP:0003139)2.54584808
53Abnormality of T cells (HP:0002843)2.51746873
54Increased IgM level (HP:0003496)2.51322475
55Purpura (HP:0000979)2.51269217
56Gangrene (HP:0100758)2.51029058
57Osteomyelitis (HP:0002754)2.50938838
58Pustule (HP:0200039)2.46326837
59Abnormal platelet volume (HP:0011876)2.43039189
60Granulocytopenia (HP:0001913)2.40908276
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36950885
62Abnormality of the pleura (HP:0002103)2.36886724
63Sepsis (HP:0100806)2.28588201
64Vertigo (HP:0002321)2.28464348
65Increased cerebral lipofuscin (HP:0011813)2.26399700
66Abnormality of the peritoneum (HP:0002585)2.24108422
67Microcytic anemia (HP:0001935)2.20654227
68Abnormality of the endocardium (HP:0004306)2.18254959
69Colitis (HP:0002583)2.17104996
70Increased serum ferritin (HP:0003281)2.13262797
71Glomerulopathy (HP:0100820)2.13230808
72Abnormality of T cell physiology (HP:0011840)2.11014033
73Hypergammaglobulinemia (HP:0010702)2.09651747
74Lymphopenia (HP:0001888)2.09450785
75Skin ulcer (HP:0200042)2.04972125
76Keratitis (HP:0000491)2.04888223
77Eosinophilia (HP:0001880)2.04275448
78Amaurosis fugax (HP:0100576)2.03970485
79Acne (HP:0001061)2.02437300
80Acute hepatic failure (HP:0006554)2.02231976
81Abnormality of iron homeostasis (HP:0011031)2.01016882
82Polyneuropathy (HP:0001271)2.00496866
83Loss of speech (HP:0002371)1.99160559
84Abnormality of cells of the lymphoid lineage (HP:0012140)1.95679823
85Hepatosplenomegaly (HP:0001433)1.95425475
86Viral hepatitis (HP:0006562)1.94039439
87Abnormality of the pericardium (HP:0001697)1.89653521
88Abnormality of liposaccharide metabolism (HP:0010968)1.89302307
89Abnormality of glycosphingolipid metabolism (HP:0004343)1.89302307
90Abnormality of glycolipid metabolism (HP:0010969)1.89302307
91Slow saccadic eye movements (HP:0000514)1.88096068
92Chronic otitis media (HP:0000389)1.86750170
93Thrombophlebitis (HP:0004418)1.85843769
94Premature loss of primary teeth (HP:0006323)1.85258318
95Cheilitis (HP:0100825)1.84947732
96Skin rash (HP:0000988)1.83146521
97Polycythemia (HP:0001901)1.81657586
98Agammaglobulinemia (HP:0004432)1.81234240
99Recurrent pneumonia (HP:0006532)1.80723788
100Increased neuronal autofluorescent lipopigment (HP:0002074)1.74534841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.39943934
2MAP4K13.35534162
3BLK3.30440468
4IRAK43.05852811
5MAP2K33.01747338
6TYK22.96604040
7CSK2.89495019
8FES2.64338770
9ERN12.39582091
10PRPF4B2.31401344
11TNK22.19855734
12ZAP702.12503256
13GRK62.12185173
14FGR1.98433088
15EPHB11.96830459
16MAP3K31.89521082
17JAK31.84505283
18BTK1.83296468
19TXK1.78205839
20HCK1.76883285
21SYK1.74195364
22MAP3K141.66606878
23TAOK11.65354572
24MAP3K131.51335677
25CSF1R1.49104046
26IKBKE1.45128854
27JAK21.42153076
28LYN1.41906089
29SIK31.40888383
30TAOK31.39950865
31JAK11.39618097
32BMPR21.37642334
33MAP3K111.32789024
34YES11.31193174
35KSR21.30676937
36MAP3K11.24958168
37TBK11.22163647
38KIT1.18165606
39MATK1.17009214
40LCK1.16626087
41IRAK11.08036661
42MARK31.07546435
43TEC1.07112449
44IRAK21.04054424
45ITK1.02529508
46CDK191.01498806
47MARK20.99556186
48STK100.98004426
49PDK10.95544201
50IKBKB0.86975252
51PIK3CG0.86306700
52PDPK10.82937494
53SIK20.81293625
54PRKD20.78512274
55PTK60.77505760
56LRRK20.77364227
57MAP3K20.77038114
58TAOK20.73250314
59MAP3K60.72295254
60TGFBR20.70695070
61FYN0.68853732
62PTK2B0.67896673
63MAP3K70.67701650
64MAPK120.66762457
65MAPK70.64269176
66SGK30.61598996
67MAP2K40.59484844
68TRIB30.57802702
69MAP3K50.56747888
70STK110.55943179
71DYRK1B0.55775896
72CDC42BPA0.55228794
73GRK70.54071510
74FGFR30.52744644
75PRKCQ0.50472531
76TESK20.49498585
77RAF10.45938718
78SGK20.45369963
79KSR10.44519300
80HIPK20.43529327
81RPS6KL10.42194012
82RPS6KC10.42194012
83PIM10.42000915
84EPHA30.41832555
85NLK0.40911323
86RET0.40025141
87SIK10.39588656
88DAPK20.39142594
89MOS0.38754596
90SMG10.38643521
91CAMKK20.38459549
92FGFR40.37975011
93STK380.37144580
94RPS6KA60.35837099
95CAMKK10.33533860
96MAPKAPK20.32943379
97PRKD10.26797576
98WNK10.26010371
99PRKCZ0.24883946
100PRKCD0.24812933

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.15473255
2* Osteoclast differentiation_Homo sapiens_hsa043803.00188321
3Staphylococcus aureus infection_Homo sapiens_hsa051502.86106733
4Graft-versus-host disease_Homo sapiens_hsa053322.41049489
5Allograft rejection_Homo sapiens_hsa053302.32137219
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.28710468
7B cell receptor signaling pathway_Homo sapiens_hsa046622.25954831
8Tuberculosis_Homo sapiens_hsa051522.25268030
9Autoimmune thyroid disease_Homo sapiens_hsa053202.14398911
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11072799
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.10801033
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02607429
13Malaria_Homo sapiens_hsa051441.92426001
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90807004
15Primary immunodeficiency_Homo sapiens_hsa053401.87650100
16Type I diabetes mellitus_Homo sapiens_hsa049401.75595036
17Chemokine signaling pathway_Homo sapiens_hsa040621.73955662
18Legionellosis_Homo sapiens_hsa051341.73007300
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71536778
20Measles_Homo sapiens_hsa051621.70493980
21Hematopoietic cell lineage_Homo sapiens_hsa046401.69970371
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69557058
23Antigen processing and presentation_Homo sapiens_hsa046121.63514229
24Acute myeloid leukemia_Homo sapiens_hsa052211.61781680
25T cell receptor signaling pathway_Homo sapiens_hsa046601.59915165
26Toxoplasmosis_Homo sapiens_hsa051451.57071316
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.53151176
28Influenza A_Homo sapiens_hsa051641.52933090
29Viral myocarditis_Homo sapiens_hsa054161.52821343
30Phagosome_Homo sapiens_hsa041451.43346968
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.37578094
32Asthma_Homo sapiens_hsa053101.37456943
33Platelet activation_Homo sapiens_hsa046111.35836423
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30635409
35African trypanosomiasis_Homo sapiens_hsa051431.30470669
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.30305413
37Herpes simplex infection_Homo sapiens_hsa051681.30035985
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.25854559
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24366677
40TNF signaling pathway_Homo sapiens_hsa046681.23725207
41Non-small cell lung cancer_Homo sapiens_hsa052231.20650790
42Hepatitis B_Homo sapiens_hsa051611.15694516
43Pertussis_Homo sapiens_hsa051331.13050271
44Rheumatoid arthritis_Homo sapiens_hsa053231.09280192
45Other glycan degradation_Homo sapiens_hsa005111.07632897
46Salmonella infection_Homo sapiens_hsa051321.03431254
47Shigellosis_Homo sapiens_hsa051310.99520060
48Hepatitis C_Homo sapiens_hsa051600.96924957
49Pancreatic cancer_Homo sapiens_hsa052120.95456639
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93605302
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91727739
52Chronic myeloid leukemia_Homo sapiens_hsa052200.90668027
53VEGF signaling pathway_Homo sapiens_hsa043700.88639513
54Apoptosis_Homo sapiens_hsa042100.86429706
55Renal cell carcinoma_Homo sapiens_hsa052110.84404879
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.84338586
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81798743
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76446897
59Prolactin signaling pathway_Homo sapiens_hsa049170.75863374
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75783306
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75107151
62Endocytosis_Homo sapiens_hsa041440.75046764
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73175578
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.72620729
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.71668951
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70341609
67Amoebiasis_Homo sapiens_hsa051460.70191345
68Lysosome_Homo sapiens_hsa041420.70079360
69Notch signaling pathway_Homo sapiens_hsa043300.69684945
70FoxO signaling pathway_Homo sapiens_hsa040680.65577660
71GnRH signaling pathway_Homo sapiens_hsa049120.64746683
72Dorso-ventral axis formation_Homo sapiens_hsa043200.64699077
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64199910
74Endometrial cancer_Homo sapiens_hsa052130.63326618
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63178027
76Epstein-Barr virus infection_Homo sapiens_hsa051690.61858107
77Choline metabolism in cancer_Homo sapiens_hsa052310.60637966
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.60485024
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60255031
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59679934
81Viral carcinogenesis_Homo sapiens_hsa052030.55177060
82HIF-1 signaling pathway_Homo sapiens_hsa040660.54634454
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53335834
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52814788
85Inositol phosphate metabolism_Homo sapiens_hsa005620.51451958
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.51256066
87Colorectal cancer_Homo sapiens_hsa052100.49982717
88Regulation of autophagy_Homo sapiens_hsa041400.49286294
89mTOR signaling pathway_Homo sapiens_hsa041500.49130535
90Type II diabetes mellitus_Homo sapiens_hsa049300.48863906
91HTLV-I infection_Homo sapiens_hsa051660.48393798
92MAPK signaling pathway_Homo sapiens_hsa040100.46671622
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46276207
94Insulin resistance_Homo sapiens_hsa049310.45411047
95Rap1 signaling pathway_Homo sapiens_hsa040150.45079879
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41200624
97ErbB signaling pathway_Homo sapiens_hsa040120.40288169
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40163707
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38724012
100Estrogen signaling pathway_Homo sapiens_hsa049150.38690991

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