LILRA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.28841260
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.28841260
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.10945888
4positive regulation by symbiont of host defense response (GO:0052509)6.00460842
5modulation by symbiont of host defense response (GO:0052031)6.00460842
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.00460842
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.00460842
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.00460842
9modulation by symbiont of host immune response (GO:0052553)6.00460842
10positive regulation of gamma-delta T cell activation (GO:0046645)5.88323606
11neutrophil activation involved in immune response (GO:0002283)5.74819795
12detection of other organism (GO:0098543)5.29067631
13antigen processing and presentation of endogenous antigen (GO:0019883)5.26524639
14response to peptidoglycan (GO:0032494)5.18018574
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.16631942
16detection of bacterium (GO:0016045)5.05945035
17macrophage activation involved in immune response (GO:0002281)5.03155527
18regulation of B cell receptor signaling pathway (GO:0050855)4.95476527
19cellular extravasation (GO:0045123)4.78605337
20negative regulation of interleukin-12 production (GO:0032695)4.64654983
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.62588889
22neutrophil activation (GO:0042119)4.62323876
23leukocyte aggregation (GO:0070486)4.61349035
24detection of external biotic stimulus (GO:0098581)4.50038484
25leukocyte migration involved in inflammatory response (GO:0002523)4.49452001
26detection of molecule of bacterial origin (GO:0032490)4.42887641
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.40799053
28respiratory burst (GO:0045730)4.40314759
29regulation of gamma-delta T cell activation (GO:0046643)4.28639266
30microglial cell activation (GO:0001774)4.27323893
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.16816367
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.14457660
33response to host immune response (GO:0052572)4.14457660
34granulocyte activation (GO:0036230)4.13837378
35regulation of interferon-beta biosynthetic process (GO:0045357)4.13094100
36immunoglobulin mediated immune response (GO:0016064)4.12797547
37neutrophil mediated immunity (GO:0002446)4.09478582
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.07942343
39response to interleukin-15 (GO:0070672)4.03200860
40detection of biotic stimulus (GO:0009595)4.02503623
41positive regulation of mast cell activation (GO:0033005)3.97130323
42regulation of mast cell degranulation (GO:0043304)3.96093627
43negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.92887488
44negative regulation of T cell mediated immunity (GO:0002710)3.90537586
45myeloid cell activation involved in immune response (GO:0002275)3.89806820
46macrophage activation (GO:0042116)3.84216891
47negative regulation of leukocyte mediated immunity (GO:0002704)3.81260009
48cellular response to interleukin-15 (GO:0071350)3.77873968
49regulation of mast cell activation (GO:0033003)3.74537951
50response to host defenses (GO:0052200)3.70942262
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.70942262
52response to host (GO:0075136)3.70942262
53regulation of mast cell activation involved in immune response (GO:0033006)3.70225323
54regulation of myeloid leukocyte mediated immunity (GO:0002886)3.62142804
55regulation of gamma-delta T cell differentiation (GO:0045586)3.59773963
56production of molecular mediator involved in inflammatory response (GO:0002532)3.59575075
57leukocyte degranulation (GO:0043299)3.47983845
58positive regulation of mast cell degranulation (GO:0043306)3.44224325
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.44224325
60myeloid leukocyte mediated immunity (GO:0002444)3.43753584
61regulation of leukocyte degranulation (GO:0043300)3.40423310
62regulation of B cell differentiation (GO:0045577)3.39192267
63antigen processing and presentation via MHC class Ib (GO:0002475)3.38528020
64negative regulation of phagocytosis (GO:0050765)3.38401023
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37675583
66B cell receptor signaling pathway (GO:0050853)3.37536254
67activated T cell proliferation (GO:0050798)3.35294076
68defense response to protozoan (GO:0042832)3.29548775
69positive regulation of B cell differentiation (GO:0045579)3.28941638
70B cell mediated immunity (GO:0019724)3.28283185
71response to muramyl dipeptide (GO:0032495)3.27637972
72type I interferon signaling pathway (GO:0060337)3.26412700
73cellular response to type I interferon (GO:0071357)3.26412700
74response to type I interferon (GO:0034340)3.25068913
75regulation of tolerance induction (GO:0002643)3.25038957
76regulation of T cell tolerance induction (GO:0002664)3.22600571
77negative regulation of interleukin-6 production (GO:0032715)3.21001975
78regulation of T cell mediated cytotoxicity (GO:0001914)3.19062863
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17699068
80negative regulation of T-helper cell differentiation (GO:0045623)3.17699068
81negative regulation of interleukin-1 production (GO:0032692)3.12610610
82positive regulation of T cell mediated cytotoxicity (GO:0001916)3.12440425
83dendritic cell migration (GO:0036336)3.12284244
84interferon-gamma-mediated signaling pathway (GO:0060333)3.10670348
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07910344
86regulation of regulated secretory pathway (GO:1903305)3.06294776
87regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02979196
88regulation of T-helper 2 cell differentiation (GO:0045628)3.01142601
89dendritic cell chemotaxis (GO:0002407)3.00893340
90germinal center formation (GO:0002467)3.00746542
91negative regulation of alpha-beta T cell activation (GO:0046636)3.00670534
92neutrophil chemotaxis (GO:0030593)2.99775297
93negative regulation of type 2 immune response (GO:0002829)2.98645360
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.97826255
95regulation of alpha-beta T cell proliferation (GO:0046640)2.97231527
96negative regulation of innate immune response (GO:0045824)2.97024586
97response to protozoan (GO:0001562)2.94141274
98myeloid leukocyte activation (GO:0002274)2.93519222
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92751513
100neutrophil migration (GO:1990266)2.92253431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.04617590
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.86933343
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.69855390
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91692114
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.85870053
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.38415546
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34164980
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26151305
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03427319
10SPI1_23547873_ChIP-Seq_NB4_Human3.01932418
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92554053
12RUNX_20019798_ChIP-Seq_JUKART_Human2.79571561
13VDR_24763502_ChIP-Seq_THP-1_Human2.72522382
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67583107
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67338869
16SPI1_23127762_ChIP-Seq_K562_Human2.64813200
17VDR_21846776_ChIP-Seq_THP-1_Human2.63810617
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63349847
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60968572
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50921706
21MYB_26560356_Chip-Seq_TH2_Human2.43676416
22SCL_19346495_ChIP-Seq_HPC-7_Human2.32198829
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23836786
24MAF_26560356_Chip-Seq_TH1_Human2.21997898
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.20785129
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15907746
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12200071
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08626423
29UTX_26944678_Chip-Seq_JUKART_Human2.05532158
30VDR_24787735_ChIP-Seq_THP-1_Human2.04271814
31MYB_26560356_Chip-Seq_TH1_Human1.99044205
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98908814
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97814872
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92242565
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.88127083
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85456700
37GATA3_27048872_Chip-Seq_THYMUS_Human1.84010359
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71486442
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67066012
40MYC_22102868_ChIP-Seq_BL_Human1.65019289
41GATA3_26560356_Chip-Seq_TH2_Human1.64862006
42MAF_26560356_Chip-Seq_TH2_Human1.64439819
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63145048
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60671349
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58701769
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52360940
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52100964
48TCF7_22412390_ChIP-Seq_EML_Mouse1.50630327
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48211846
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.47920220
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46317313
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.46270809
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44921745
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43180318
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.43001355
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41178007
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38408416
58KDM2B_26808549_Chip-Seq_DND41_Human1.32935245
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32531629
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31543231
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29782672
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29326108
63PU_27001747_Chip-Seq_BMDM_Mouse1.26015821
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25718835
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25388821
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22102539
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21474062
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19301463
69* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18760128
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17594170
71BCL6_27268052_Chip-Seq_Bcells_Human1.14857881
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14418905
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14319614
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12912299
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11657079
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11511802
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09189778
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06972208
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05718089
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05036260
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03030534
82GATA1_19941826_ChIP-Seq_K562_Human1.01391998
83GATA1_22025678_ChIP-Seq_K562_Human0.99939932
84* BCOR_27268052_Chip-Seq_Bcells_Human0.96361744
85SPI1_20517297_ChIP-Seq_HL60_Human0.92292185
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.90973750
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89652243
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89171323
89* SMRT_27268052_Chip-Seq_Bcells_Human0.88704319
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86148598
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.85685464
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83054501
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81701209
94GATA2_19941826_ChIP-Seq_K562_Human0.80491824
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.80484367
96STAT1_20625510_ChIP-Seq_HELA_Human0.78386164
97* P300_27268052_Chip-Seq_Bcells_Human0.76519752
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76255756
99* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72911450
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72746420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.21731232
2MP0003436_decreased_susceptibility_to4.29352870
3MP0001835_abnormal_antigen_presentation3.98236856
4MP0003303_peritoneal_inflammation3.64713621
5MP0002419_abnormal_innate_immunity3.35619031
6MP0005671_abnormal_response_to3.10507859
7MP0009785_altered_susceptibility_to3.07646974
8MP0005025_abnormal_response_to3.00288759
9MP0001800_abnormal_humoral_immune2.98725533
10MP0000685_abnormal_immune_system2.96323154
11MP0005387_immune_system_phenotype2.86707186
12MP0001790_abnormal_immune_system2.86707186
13MP0005000_abnormal_immune_tolerance2.85958818
14MP0006082_CNS_inflammation2.75914758
15MP0002723_abnormal_immune_serum2.68963066
16MP0002420_abnormal_adaptive_immunity2.61963958
17MP0001819_abnormal_immune_cell2.59327734
18MP0002452_abnormal_antigen_presenting2.58930114
19MP0002148_abnormal_hypersensitivity_rea2.50484978
20MP0001533_abnormal_skeleton_physiology2.18745981
21MP0003300_gastrointestinal_ulcer2.03610571
22MP0002405_respiratory_system_inflammati2.03497099
23MP0005464_abnormal_platelet_physiology1.99869353
24MP0002132_abnormal_respiratory_system1.97728993
25MP0003191_abnormal_cellular_cholesterol1.92816950
26MP0000716_abnormal_immune_system1.91519266
27MP0002398_abnormal_bone_marrow1.90544866
28MP0003172_abnormal_lysosome_physiology1.90230922
29MP0003763_abnormal_thymus_physiology1.86727722
30MP0009278_abnormal_bone_marrow1.84702273
31MP0001845_abnormal_inflammatory_respons1.81712989
32MP0010155_abnormal_intestine_physiology1.75741874
33MP0009764_decreased_sensitivity_to1.73102182
34MP0003828_pulmonary_edema1.72848688
35MP0002396_abnormal_hematopoietic_system1.65827785
36MP0002277_abnormal_respiratory_mucosa1.63926848
37MP0000689_abnormal_spleen_morphology1.61993272
38MP0000465_gastrointestinal_hemorrhage1.58296898
39MP0008260_abnormal_autophagy1.57350019
40MP0002722_abnormal_immune_system1.56139137
41MP0003866_abnormal_defecation1.54737443
42MP0008469_abnormal_protein_level1.54442236
43MP0003183_abnormal_peptide_metabolism1.54309372
44MP0002429_abnormal_blood_cell1.49554894
45MP0004947_skin_inflammation1.43626842
46MP0009333_abnormal_splenocyte_physiolog1.41080617
47MP0004381_abnormal_hair_follicle1.36178827
48MP0000703_abnormal_thymus_morphology1.36025906
49MP0004883_abnormal_blood_vessel1.35515810
50MP0005397_hematopoietic_system_phenotyp1.33429109
51MP0001545_abnormal_hematopoietic_system1.33429109
52MP0005310_abnormal_salivary_gland1.30705094
53MP0001986_abnormal_taste_sensitivity1.30545641
54MP0003075_altered_response_to1.27252215
55MP0005075_abnormal_melanosome_morpholog1.13767050
56MP0001851_eye_inflammation1.13399762
57MP0000858_altered_metastatic_potential1.07160828
58MP0002998_abnormal_bone_remodeling1.06592853
59MP0005164_abnormal_response_to1.05822498
60MP0003806_abnormal_nucleotide_metabolis1.03660814
61MP0005451_abnormal_body_composition1.02465167
62MP0003690_abnormal_glial_cell0.99530602
63MP0004510_myositis0.96758214
64MP0002166_altered_tumor_susceptibility0.94492591
65MP0005166_decreased_susceptibility_to0.94358858
66MP0001663_abnormal_digestive_system0.89688385
67MP0005058_abnormal_lysosome_morphology0.86067946
68MP0000343_altered_response_to0.86010371
69MP0005390_skeleton_phenotype0.85236278
70MP0009763_increased_sensitivity_to0.84226296
71MP0002138_abnormal_hepatobiliary_system0.78945427
72MP0000015_abnormal_ear_pigmentation0.78367115
73MP0000569_abnormal_digit_pigmentation0.77689928
74MP0008004_abnormal_stomach_pH0.77455855
75MP0005084_abnormal_gallbladder_morpholo0.75214891
76MP0002928_abnormal_bile_duct0.74484239
77MP0001873_stomach_inflammation0.74360423
78MP0001853_heart_inflammation0.71861458
79MP0003045_fibrosis0.71831196
80MP0003448_altered_tumor_morphology0.69338664
81MP0004808_abnormal_hematopoietic_stem0.69168560
82MP0005377_hearing/vestibular/ear_phenot0.69159624
83MP0003878_abnormal_ear_physiology0.69159624
84MP0009765_abnormal_xenobiotic_induced0.69002448
85MP0000604_amyloidosis0.68727515
86MP0004130_abnormal_muscle_cell0.68597311
87MP0003656_abnormal_erythrocyte_physiolo0.66978088
88MP0000490_abnormal_crypts_of0.65054780
89MP0005083_abnormal_biliary_tract0.64215029
90MP0002693_abnormal_pancreas_physiology0.62520815
91MP0005319_abnormal_enzyme/_coenzyme0.61100553
92MP0002653_abnormal_ependyma_morphology0.60984988
93MP0003795_abnormal_bone_structure0.57301237
94MP0002006_tumorigenesis0.56353317
95MP0002933_joint_inflammation0.55515936
96MP0000249_abnormal_blood_vessel0.54546618
97MP0003252_abnormal_bile_duct0.54234925
98MP0008874_decreased_physiological_sensi0.52655323
99MP0005167_abnormal_blood-brain_barrier0.51493966
100MP0005174_abnormal_tail_pigmentation0.51194191

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.57025885
2Myositis (HP:0100614)6.34390010
3Recurrent abscess formation (HP:0002722)6.30099832
4Recurrent bacterial skin infections (HP:0005406)6.16591910
5Orchitis (HP:0100796)5.92694850
6Stomatitis (HP:0010280)5.77394697
7Optic neuritis (HP:0100653)5.69318476
8Retrobulbar optic neuritis (HP:0100654)5.69318476
9Abnormality of macrophages (HP:0004311)5.56320097
10Elevated erythrocyte sedimentation rate (HP:0003565)5.31596690
11Recurrent gram-negative bacterial infections (HP:0005420)5.09521145
12Recurrent fungal infections (HP:0002841)4.49757028
13Gastrointestinal infarctions (HP:0005244)4.34363715
14Obstructive lung disease (HP:0006536)4.29795178
15Chronic obstructive pulmonary disease (HP:0006510)4.29795178
16Hypochromic microcytic anemia (HP:0004840)4.28287112
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.28191161
18Mediastinal lymphadenopathy (HP:0100721)4.22697808
19Meningitis (HP:0001287)4.18621292
20Recurrent skin infections (HP:0001581)4.17348900
21Encephalitis (HP:0002383)4.10748966
22Keratoconjunctivitis sicca (HP:0001097)4.06527841
23Recurrent cutaneous fungal infections (HP:0011370)3.93853911
24Chronic mucocutaneous candidiasis (HP:0002728)3.93853911
25Keratoconjunctivitis (HP:0001096)3.86870854
26Hypochromic anemia (HP:0001931)3.61677815
27Urticaria (HP:0001025)3.59670170
28Vasculitis (HP:0002633)3.56044139
29Increased IgE level (HP:0003212)3.41727629
30Spontaneous hematomas (HP:0007420)3.37648153
31Episodic fever (HP:0001954)3.35069281
32Hemoptysis (HP:0002105)3.34288763
33Prolonged bleeding time (HP:0003010)3.31934243
34Gingivitis (HP:0000230)3.29496313
35Chest pain (HP:0100749)3.29386944
36Pulmonary infiltrates (HP:0002113)3.13688219
37Panhypogammaglobulinemia (HP:0003139)3.04276847
38Leukocytosis (HP:0001974)3.03646793
39Anorexia (HP:0002039)2.96775548
40Arterial thrombosis (HP:0004420)2.90362726
41Amyloidosis (HP:0011034)2.89024798
42T lymphocytopenia (HP:0005403)2.86589941
43Cellulitis (HP:0100658)2.84393462
44Abnormality of T cell number (HP:0011839)2.83105710
45Pulmonary embolism (HP:0002204)2.75888853
46Gingival bleeding (HP:0000225)2.75612828
47Abnormality of T cells (HP:0002843)2.71468254
48Petechiae (HP:0000967)2.65636199
49Recurrent viral infections (HP:0004429)2.64744381
50Peritonitis (HP:0002586)2.63575786
51Inflammation of the large intestine (HP:0002037)2.63217184
52Pustule (HP:0200039)2.61150832
53Granulocytopenia (HP:0001913)2.60974610
54Epistaxis (HP:0000421)2.59100134
55Microcytic anemia (HP:0001935)2.54229730
56Increased IgM level (HP:0003496)2.53966826
57Abnormality of the pleura (HP:0002103)2.51999834
58Gangrene (HP:0100758)2.49515665
59Gastrointestinal inflammation (HP:0004386)2.49299943
60Abnormality of T cell physiology (HP:0011840)2.46425883
61Osteomyelitis (HP:0002754)2.44300240
62Increased cerebral lipofuscin (HP:0011813)2.43532681
63Sepsis (HP:0100806)2.35756368
64Eosinophilia (HP:0001880)2.24764642
65Keratitis (HP:0000491)2.23541841
66Abnormality of the endocardium (HP:0004306)2.19672476
67Vertigo (HP:0002321)2.16501000
68Lymphopenia (HP:0001888)2.16012207
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.14499332
70Abnormality of liposaccharide metabolism (HP:0010968)2.14231691
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.14231691
72Abnormality of glycolipid metabolism (HP:0010969)2.14231691
73Hypergammaglobulinemia (HP:0010702)2.13417089
74Chronic otitis media (HP:0000389)2.13337316
75Abnormality of iron homeostasis (HP:0011031)2.12735109
76Increased serum ferritin (HP:0003281)2.09217173
77Purpura (HP:0000979)2.06879124
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.05730842
79Glomerulopathy (HP:0100820)2.05349564
80Agammaglobulinemia (HP:0004432)2.04372850
81Abnormality of the pericardium (HP:0001697)2.04126856
82Polyneuropathy (HP:0001271)2.03197124
83Acne (HP:0001061)2.00358242
84Abnormality of the peritoneum (HP:0002585)2.00138523
85Abnormality of cells of the lymphoid lineage (HP:0012140)1.99686708
86Hepatosplenomegaly (HP:0001433)1.97912746
87Cheilitis (HP:0100825)1.97720427
88Stomach cancer (HP:0012126)1.95607947
89Abnormality of eosinophils (HP:0001879)1.93958319
90Skin rash (HP:0000988)1.93105158
91Skin ulcer (HP:0200042)1.92943006
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91156314
93Recurrent pneumonia (HP:0006532)1.90601386
94Acute hepatic failure (HP:0006554)1.90328844
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89842377
96Loss of speech (HP:0002371)1.89546082
97Abnormality of transition element cation homeostasis (HP:0011030)1.86029221
98Colitis (HP:0002583)1.84668867
99Amaurosis fugax (HP:0100576)1.83184236
100Autoimmune thrombocytopenia (HP:0001973)1.81559226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.08878000
2MAP4K13.59504211
3IRAK43.35407796
4BLK3.25069327
5MAP2K32.94256104
6FES2.87105336
7TYK22.75869466
8TNK22.68560193
9CSK2.65316508
10GRK62.43990454
11ERN12.43044397
12TXK2.20578298
13ZAP702.01699512
14BTK1.94745218
15TAOK31.87971676
16HCK1.87089078
17SYK1.84685707
18EPHB11.84175534
19TAOK11.83895943
20FGR1.74597314
21MAP3K31.73324966
22MAP3K111.68808811
23JAK31.67234038
24KIT1.65101939
25LYN1.57105367
26MAP3K141.55504813
27CSF1R1.48553001
28IKBKE1.48505741
29JAK21.39027066
30PRPF4B1.38982886
31SIK31.38371243
32CDK191.33185005
33TBK11.29122943
34LCK1.26063767
35TEC1.24297066
36ITK1.18287339
37IRAK11.17338271
38MARK31.16872425
39YES11.13147341
40MAP3K11.10894791
41MAP3K131.10745868
42JAK11.10322736
43SIK21.10162008
44MATK1.07836911
45IKBKB1.04130644
46BMPR20.98988296
47PRKD20.95494315
48KSR20.95424719
49MARK20.87683136
50PDK10.86277990
51STK100.79926809
52DAPK20.79772314
53PTK60.79650729
54IRAK20.78038607
55PTK2B0.76484202
56STK110.73734157
57MAP2K40.73446131
58FRK0.71608641
59PRKCQ0.68439280
60PDPK10.68151037
61PIK3CG0.67629337
62MAP3K70.65424495
63FYN0.63967621
64TGFBR20.63273187
65MAPK120.60393193
66TAOK20.59904090
67MAP2K60.59757162
68GRK70.59660629
69MAP3K60.56915720
70MAPK70.54318306
71TESK20.53975949
72MAP3K50.49917957
73EPHA30.49548487
74MAP3K20.49196168
75HIPK20.49030903
76DYRK1B0.48359283
77RPS6KA60.45321435
78LRRK20.44732932
79RPS6KL10.42816684
80RPS6KC10.42816684
81OXSR10.42367924
82SGK30.40673553
83NLK0.39413371
84CAMKK20.38782649
85PIM10.38614486
86STK380.36439245
87PRKCZ0.36363385
88SGK20.34134052
89ADRBK20.33598215
90MAPKAPK20.33363950
91ACVR1B0.32330508
92ABL10.31977220
93PRKCD0.30962213
94RAF10.30531840
95PRKCH0.29279253
96CDC42BPA0.29239121
97ADRBK10.28449245
98CAMKK10.28070814
99DYRK30.27643912
100FGFR30.27253575

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.22095020
2Staphylococcus aureus infection_Homo sapiens_hsa051503.11865331
3* Osteoclast differentiation_Homo sapiens_hsa043803.06331953
4Graft-versus-host disease_Homo sapiens_hsa053322.70585116
5Allograft rejection_Homo sapiens_hsa053302.66181385
6Autoimmune thyroid disease_Homo sapiens_hsa053202.45755977
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.37608457
8Tuberculosis_Homo sapiens_hsa051522.32997034
9Primary immunodeficiency_Homo sapiens_hsa053402.27882237
10B cell receptor signaling pathway_Homo sapiens_hsa046622.19823938
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.16778154
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07906314
13Type I diabetes mellitus_Homo sapiens_hsa049402.06189582
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04181606
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98422909
16Malaria_Homo sapiens_hsa051441.95483214
17Hematopoietic cell lineage_Homo sapiens_hsa046401.86586251
18Antigen processing and presentation_Homo sapiens_hsa046121.83138522
19Chemokine signaling pathway_Homo sapiens_hsa040621.77308005
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.77101469
21Asthma_Homo sapiens_hsa053101.71403716
22Measles_Homo sapiens_hsa051621.70840929
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69229068
24Legionellosis_Homo sapiens_hsa051341.66141392
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.55579271
26T cell receptor signaling pathway_Homo sapiens_hsa046601.53989290
27Phagosome_Homo sapiens_hsa041451.53500626
28Acute myeloid leukemia_Homo sapiens_hsa052211.50334297
29Viral myocarditis_Homo sapiens_hsa054161.49581273
30African trypanosomiasis_Homo sapiens_hsa051431.49120413
31Toxoplasmosis_Homo sapiens_hsa051451.48962068
32Influenza A_Homo sapiens_hsa051641.45973092
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.39467811
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38825303
35Herpes simplex infection_Homo sapiens_hsa051681.33644665
36Rheumatoid arthritis_Homo sapiens_hsa053231.26198840
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24734119
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23843157
39TNF signaling pathway_Homo sapiens_hsa046681.21898682
40Platelet activation_Homo sapiens_hsa046111.16134684
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07432846
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.07317814
43Pertussis_Homo sapiens_hsa051331.04756878
44Other glycan degradation_Homo sapiens_hsa005111.04303372
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03584482
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01852711
47Hepatitis B_Homo sapiens_hsa051610.98887760
48Hepatitis C_Homo sapiens_hsa051600.92119663
49Shigellosis_Homo sapiens_hsa051310.90763404
50Salmonella infection_Homo sapiens_hsa051320.90591083
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87281627
52Lysosome_Homo sapiens_hsa041420.86781852
53Non-small cell lung cancer_Homo sapiens_hsa052230.86476132
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86097437
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84989757
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84785778
57Regulation of autophagy_Homo sapiens_hsa041400.82953429
58Apoptosis_Homo sapiens_hsa042100.74721690
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73551514
60VEGF signaling pathway_Homo sapiens_hsa043700.67322454
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66845974
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.66537561
63Endocytosis_Homo sapiens_hsa041440.65376858
64Prolactin signaling pathway_Homo sapiens_hsa049170.65022214
65Dorso-ventral axis formation_Homo sapiens_hsa043200.63974486
66Pancreatic cancer_Homo sapiens_hsa052120.63602103
67Collecting duct acid secretion_Homo sapiens_hsa049660.60550575
68Epstein-Barr virus infection_Homo sapiens_hsa051690.60123123
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.57767798
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.57392710
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.54848568
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54526460
73FoxO signaling pathway_Homo sapiens_hsa040680.54354449
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.52744485
75Renal cell carcinoma_Homo sapiens_hsa052110.52315374
76Chronic myeloid leukemia_Homo sapiens_hsa052200.51317080
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.51195694
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50447141
79GnRH signaling pathway_Homo sapiens_hsa049120.46634329
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44814190
81Choline metabolism in cancer_Homo sapiens_hsa052310.44275817
82MAPK signaling pathway_Homo sapiens_hsa040100.44242026
83Notch signaling pathway_Homo sapiens_hsa043300.43421767
84Viral carcinogenesis_Homo sapiens_hsa052030.43216217
85Type II diabetes mellitus_Homo sapiens_hsa049300.42931085
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40817444
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40786736
88Amoebiasis_Homo sapiens_hsa051460.39981345
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38942233
90Insulin resistance_Homo sapiens_hsa049310.37947737
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37008438
92HTLV-I infection_Homo sapiens_hsa051660.35828456
93Arachidonic acid metabolism_Homo sapiens_hsa005900.35258242
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35024845
95HIF-1 signaling pathway_Homo sapiens_hsa040660.33791875
96Rap1 signaling pathway_Homo sapiens_hsa040150.32105066
97Inositol phosphate metabolism_Homo sapiens_hsa005620.30802129
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30386825
99mTOR signaling pathway_Homo sapiens_hsa041500.28318499
100Ether lipid metabolism_Homo sapiens_hsa005650.27537939

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