LILRA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.43103810
2negative regulation of interleukin-12 production (GO:0032695)5.25306014
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.17360522
4negative regulation of cell killing (GO:0031342)5.17360522
5neutrophil activation involved in immune response (GO:0002283)5.08173447
6positive regulation of gamma-delta T cell activation (GO:0046645)4.98708251
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.97884041
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.97884041
9modulation by symbiont of host immune response (GO:0052553)4.97884041
10positive regulation by symbiont of host defense response (GO:0052509)4.97884041
11modulation by symbiont of host defense response (GO:0052031)4.97884041
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.97884041
13regulation of T cell tolerance induction (GO:0002664)4.67281158
14macrophage activation involved in immune response (GO:0002281)4.65305575
15regulation of dendritic cell antigen processing and presentation (GO:0002604)4.55221036
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54683440
17production of molecular mediator involved in inflammatory response (GO:0002532)4.52297340
18positive regulation of type 2 immune response (GO:0002830)4.49544235
19regulation of T-helper 1 cell differentiation (GO:0045625)4.47265309
20detection of other organism (GO:0098543)4.44117591
21regulation of tolerance induction (GO:0002643)4.28513912
22detection of bacterium (GO:0016045)4.17892524
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10144200
24positive regulation of tolerance induction (GO:0002645)4.07635002
25immunoglobulin mediated immune response (GO:0016064)4.03484663
26detection of molecule of bacterial origin (GO:0032490)4.02692159
27antigen processing and presentation of endogenous antigen (GO:0019883)3.98876540
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.96405976
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.83711742
30detection of external biotic stimulus (GO:0098581)3.83402975
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78510406
32T-helper 1 type immune response (GO:0042088)3.77507724
33regulation of interferon-beta biosynthetic process (GO:0045357)3.76850872
34positive regulation of antigen processing and presentation (GO:0002579)3.74513462
35neutrophil activation (GO:0042119)3.72809132
36granulocyte activation (GO:0036230)3.68433287
37leukocyte aggregation (GO:0070486)3.66557949
38regulation of antigen processing and presentation (GO:0002577)3.66242361
39cellular response to type I interferon (GO:0071357)3.61386901
40type I interferon signaling pathway (GO:0060337)3.61386901
41positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.58685370
42response to type I interferon (GO:0034340)3.56711770
43interferon-gamma-mediated signaling pathway (GO:0060333)3.55018521
44cellular extravasation (GO:0045123)3.54187651
45regulation of interleukin-12 production (GO:0032655)3.53994520
46defense response to protozoan (GO:0042832)3.52290965
47regulation of gamma-delta T cell activation (GO:0046643)3.49884525
48regulation of type 2 immune response (GO:0002828)3.45861502
49response to host immune response (GO:0052572)3.43364904
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43364904
51detection of biotic stimulus (GO:0009595)3.43187847
52regulation of mast cell degranulation (GO:0043304)3.42121273
53microglial cell activation (GO:0001774)3.41260173
54positive regulation of T-helper cell differentiation (GO:0045624)3.39116218
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37056736
56myeloid cell activation involved in immune response (GO:0002275)3.34121425
57macrophage activation (GO:0042116)3.34024508
58dendritic cell chemotaxis (GO:0002407)3.32389920
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31398647
60negative regulation of T cell mediated immunity (GO:0002710)3.29969509
61respiratory burst (GO:0045730)3.28658757
62response to muramyl dipeptide (GO:0032495)3.27848949
63regulation of T-helper 2 cell differentiation (GO:0045628)3.24983700
64response to protozoan (GO:0001562)3.24273770
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.22951186
66negative regulation of cytokine production involved in immune response (GO:0002719)3.20627325
67positive regulation of interleukin-10 production (GO:0032733)3.19316161
68regulation of B cell receptor signaling pathway (GO:0050855)3.18737593
69regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.18288282
70positive regulation of interleukin-12 production (GO:0032735)3.17947611
71regulation of interferon-alpha production (GO:0032647)3.15250502
72regulation of mast cell activation involved in immune response (GO:0033006)3.14673265
73positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.14594824
74regulation of T-helper cell differentiation (GO:0045622)3.13125589
75germinal center formation (GO:0002467)3.12321868
76B cell mediated immunity (GO:0019724)3.12165470
77positive regulation of interleukin-1 beta secretion (GO:0050718)3.10771456
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09209967
79response to host (GO:0075136)3.09209967
80response to host defenses (GO:0052200)3.09209967
81positive regulation of mast cell activation (GO:0033005)3.07570015
82regulation of interleukin-1 beta secretion (GO:0050706)3.07505796
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07299123
84positive regulation of toll-like receptor signaling pathway (GO:0034123)3.06995699
85positive regulation of NF-kappaB import into nucleus (GO:0042346)3.06836865
86regulation of interleukin-10 production (GO:0032653)3.06599716
87positive regulation of interferon-alpha production (GO:0032727)3.06526866
88regulation of chronic inflammatory response (GO:0002676)3.04566760
89regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.03591716
90neutrophil mediated immunity (GO:0002446)3.02288510
91positive regulation of T-helper 1 type immune response (GO:0002827)3.00552223
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99774832
93NIK/NF-kappaB signaling (GO:0038061)2.99585737
94leukocyte migration involved in inflammatory response (GO:0002523)2.99585037
95regulation of mast cell activation (GO:0033003)2.98327082
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.98019342
97positive regulation of interleukin-17 production (GO:0032740)2.97702031
98regulation of leukocyte degranulation (GO:0043300)2.95214367
99negative regulation of leukocyte mediated immunity (GO:0002704)2.94084444
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.91651641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.02502025
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.20235975
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.99965895
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.75395371
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61762134
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.53208376
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44090782
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.29574033
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25539845
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18225608
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11724382
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.00804862
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00192199
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.87259465
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65804152
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.60419462
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52631152
18SPI1_23547873_ChIP-Seq_NB4_Human2.48302583
19VDR_24763502_ChIP-Seq_THP-1_Human2.45991645
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41872354
21SPI1_23127762_ChIP-Seq_K562_Human2.41377697
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.38797142
23VDR_21846776_ChIP-Seq_THP-1_Human2.30791771
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30549764
25RUNX_20019798_ChIP-Seq_JUKART_Human2.18239059
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11586411
27VDR_24787735_ChIP-Seq_THP-1_Human2.04497318
28SCL_19346495_ChIP-Seq_HPC-7_Human2.02574600
29MAF_26560356_Chip-Seq_TH1_Human2.00810248
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.00016028
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.96281421
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91192806
33MYB_26560356_Chip-Seq_TH2_Human1.88286710
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88145457
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87979023
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75476256
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74081420
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73944802
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67879025
40UTX_26944678_Chip-Seq_JUKART_Human1.63909587
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59381729
42MYB_26560356_Chip-Seq_TH1_Human1.58530561
43GATA1_22025678_ChIP-Seq_K562_Human1.56764987
44TCF7_22412390_ChIP-Seq_EML_Mouse1.56568417
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55726422
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52124908
47MYC_22102868_ChIP-Seq_BL_Human1.50142542
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46991769
49KDM2B_26808549_Chip-Seq_DND41_Human1.44242894
50PU_27001747_Chip-Seq_BMDM_Mouse1.42920912
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40541790
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.39887463
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37334693
54MAF_26560356_Chip-Seq_TH2_Human1.36655245
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34351810
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34293929
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34054562
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32116569
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32097442
60GATA3_27048872_Chip-Seq_THYMUS_Human1.32021832
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31447445
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30604581
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30098294
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29316174
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.29047055
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28986019
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28250407
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28051125
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28008092
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25939635
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19277215
72LXR_22292898_ChIP-Seq_THP-1_Human1.18204482
73GATA1_19941826_ChIP-Seq_K562_Human1.17471970
74GATA3_26560356_Chip-Seq_TH2_Human1.14214474
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13128815
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11601173
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07787850
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.07723000
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06876629
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03640444
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01894097
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01236914
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96976186
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96462419
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96386502
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94573605
87BCL6_27268052_Chip-Seq_Bcells_Human0.94005920
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91507829
89BCOR_27268052_Chip-Seq_Bcells_Human0.89161852
90EGR1_19032775_ChIP-ChIP_M12_Human0.87337849
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.87149587
92STAT1_20625510_ChIP-Seq_HELA_Human0.86086959
93GATA2_19941826_ChIP-Seq_K562_Human0.83462476
94TFEB_21752829_ChIP-Seq_HELA_Human0.82436516
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79395883
96NCOR1_26117541_ChIP-Seq_K562_Human0.77486399
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76792262
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71937011
99KDM2B_26808549_Chip-Seq_K562_Human0.71405887
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71091138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.85837909
2MP0003724_increased_susceptibility_to4.49021259
3MP0003436_decreased_susceptibility_to3.95041418
4MP0001835_abnormal_antigen_presentation3.79512324
5MP0009785_altered_susceptibility_to3.48428609
6MP0006082_CNS_inflammation3.39182896
7MP0002148_abnormal_hypersensitivity_rea3.30109906
8MP0002419_abnormal_innate_immunity3.10958358
9MP0005671_abnormal_response_to3.00690759
10MP0005000_abnormal_immune_tolerance2.98619802
11MP0000685_abnormal_immune_system2.94579329
12MP0005025_abnormal_response_to2.91925223
13MP0001790_abnormal_immune_system2.90690592
14MP0005387_immune_system_phenotype2.90690592
15MP0001800_abnormal_humoral_immune2.70008772
16MP0002723_abnormal_immune_serum2.56277658
17MP0002452_abnormal_antigen_presenting2.54713007
18MP0003300_gastrointestinal_ulcer2.36894786
19MP0004510_myositis2.31553918
20MP0001819_abnormal_immune_cell2.27846664
21MP0002420_abnormal_adaptive_immunity2.26483940
22MP0001533_abnormal_skeleton_physiology2.17958934
23MP0005058_abnormal_lysosome_morphology2.15538724
24MP0009764_decreased_sensitivity_to2.05024788
25MP0003172_abnormal_lysosome_physiology1.98557738
26MP0003191_abnormal_cellular_cholesterol1.98386527
27MP0001845_abnormal_inflammatory_respons1.95572300
28MP0002405_respiratory_system_inflammati1.93390523
29MP0010155_abnormal_intestine_physiology1.92258833
30MP0009278_abnormal_bone_marrow1.90930562
31MP0004947_skin_inflammation1.88022591
32MP0003075_altered_response_to1.87644826
33MP0005451_abnormal_body_composition1.83419180
34MP0005464_abnormal_platelet_physiology1.77673856
35MP0008469_abnormal_protein_level1.68957828
36MP0000343_altered_response_to1.68339752
37MP0000716_abnormal_immune_system1.64820670
38MP0005310_abnormal_salivary_gland1.61205874
39MP0008260_abnormal_autophagy1.55493001
40MP0002398_abnormal_bone_marrow1.51389699
41MP0009333_abnormal_splenocyte_physiolog1.49811614
42MP0005397_hematopoietic_system_phenotyp1.46300700
43MP0001545_abnormal_hematopoietic_system1.46300700
44MP0002998_abnormal_bone_remodeling1.44296503
45MP0003690_abnormal_glial_cell1.37504906
46MP0003828_pulmonary_edema1.35564086
47MP0000858_altered_metastatic_potential1.35141124
48MP0003448_altered_tumor_morphology1.35040285
49MP0003806_abnormal_nucleotide_metabolis1.34615079
50MP0008004_abnormal_stomach_pH1.31602152
51MP0005166_decreased_susceptibility_to1.29697607
52MP0009840_abnormal_foam_cell1.27923243
53MP0002429_abnormal_blood_cell1.27581170
54MP0003763_abnormal_thymus_physiology1.24208813
55MP0001853_heart_inflammation1.23365187
56MP0000689_abnormal_spleen_morphology1.23310921
57MP0002722_abnormal_immune_system1.22390573
58MP0005167_abnormal_blood-brain_barrier1.20981830
59MP0003183_abnormal_peptide_metabolism1.16513987
60MP0002277_abnormal_respiratory_mucosa1.15026471
61MP0000604_amyloidosis1.14891067
62MP0000465_gastrointestinal_hemorrhage1.08513730
63MP0005164_abnormal_response_to1.07895947
64MP0002132_abnormal_respiratory_system1.06421874
65MP0003656_abnormal_erythrocyte_physiolo1.02920291
66MP0009763_increased_sensitivity_to1.01872094
67MP0004883_abnormal_blood_vessel1.01817141
68MP0003866_abnormal_defecation0.97004694
69MP0002332_abnormal_exercise_endurance0.94532154
70MP0003453_abnormal_keratinocyte_physiol0.93901720
71MP0002138_abnormal_hepatobiliary_system0.93482784
72MP0001851_eye_inflammation0.93130134
73MP0002254_reproductive_system_inflammat0.93071119
74MP0009765_abnormal_xenobiotic_induced0.91672845
75MP0002139_abnormal_hepatobiliary_system0.89778961
76MP0005390_skeleton_phenotype0.87864961
77MP0006054_spinal_hemorrhage0.83866642
78MP0000703_abnormal_thymus_morphology0.81153599
79MP0001663_abnormal_digestive_system0.80626216
80MP0003091_abnormal_cell_migration0.70285882
81MP0000920_abnormal_myelination0.69431727
82MP0008874_decreased_physiological_sensi0.68900892
83MP0003795_abnormal_bone_structure0.67656080
84MP0004808_abnormal_hematopoietic_stem0.67451040
85MP0003045_fibrosis0.61959173
86MP0000249_abnormal_blood_vessel0.61813391
87MP0001873_stomach_inflammation0.59639650
88MP0002933_joint_inflammation0.59349621
89MP0005319_abnormal_enzyme/_coenzyme0.58609168
90MP0003221_abnormal_cardiomyocyte_apopto0.55695382
91MP0000490_abnormal_crypts_of0.55586047
92MP0002693_abnormal_pancreas_physiology0.55524187
93MP0002166_altered_tumor_susceptibility0.52637961
94MP0000371_diluted_coat_color0.50773963
95MP0005076_abnormal_cell_differentiation0.50529123
96MP0002006_tumorigenesis0.47230329
97MP0000609_abnormal_liver_physiology0.47168551
98MP0005535_abnormal_body_temperature0.44849308
99MP0001542_abnormal_bone_strength0.42942788
100MP0005381_digestive/alimentary_phenotyp0.42514422

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.08582568
2Abnormality of macrophages (HP:0004311)5.93800124
3Recurrent bacterial skin infections (HP:0005406)5.89625038
4Recurrent abscess formation (HP:0002722)5.77925539
5Orchitis (HP:0100796)5.67698048
6Myositis (HP:0100614)5.57399666
7Optic neuritis (HP:0100653)5.56248354
8Retrobulbar optic neuritis (HP:0100654)5.56248354
9Stomatitis (HP:0010280)4.76761451
10Recurrent gram-negative bacterial infections (HP:0005420)4.63270472
11Gastrointestinal infarctions (HP:0005244)4.42524707
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.36907431
13Abnormality of glycolipid metabolism (HP:0010969)4.36907431
14Abnormality of liposaccharide metabolism (HP:0010968)4.36907431
15Mediastinal lymphadenopathy (HP:0100721)4.23000625
16Elevated erythrocyte sedimentation rate (HP:0003565)3.95149451
17Keratoconjunctivitis sicca (HP:0001097)3.94968488
18Chronic obstructive pulmonary disease (HP:0006510)3.66423312
19Obstructive lung disease (HP:0006536)3.66423312
20Keratoconjunctivitis (HP:0001096)3.62653752
21Recurrent fungal infections (HP:0002841)3.59664798
22Recurrent skin infections (HP:0001581)3.59155349
23Vasculitis (HP:0002633)3.45196503
24Increased cerebral lipofuscin (HP:0011813)3.42090212
25Meningitis (HP:0001287)3.33083932
26Hemoptysis (HP:0002105)3.29235364
27Loss of speech (HP:0002371)3.27427599
28Encephalitis (HP:0002383)3.23528407
29Pulmonary infiltrates (HP:0002113)3.16758761
30Amyloidosis (HP:0011034)3.15619844
31Urticaria (HP:0001025)3.08893384
32Gingivitis (HP:0000230)3.06599942
33Increased IgE level (HP:0003212)3.06061254
34Increased IgM level (HP:0003496)3.02694042
35Disinhibition (HP:0000734)2.95240077
36Dysostosis multiplex (HP:0000943)2.92775210
37Anorexia (HP:0002039)2.91123629
38Spontaneous hematomas (HP:0007420)2.90909696
39Chest pain (HP:0100749)2.90705728
40Episodic fever (HP:0001954)2.90546959
41Gangrene (HP:0100758)2.88600274
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.88539360
43Vacuolated lymphocytes (HP:0001922)2.88513117
44Recurrent cutaneous fungal infections (HP:0011370)2.80196379
45Chronic mucocutaneous candidiasis (HP:0002728)2.80196379
46Arterial thrombosis (HP:0004420)2.79815111
47Systemic lupus erythematosus (HP:0002725)2.77822773
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.73338927
49Recurrent viral infections (HP:0004429)2.72995892
50Autoimmune thrombocytopenia (HP:0001973)2.70148015
51T lymphocytopenia (HP:0005403)2.70085317
52Leukocytosis (HP:0001974)2.69897152
53Petechiae (HP:0000967)2.66925781
54Increased serum ferritin (HP:0003281)2.64908363
55Abnormality of T cell number (HP:0011839)2.59123439
56Purpura (HP:0000979)2.51279912
57Hematochezia (HP:0002573)2.50354902
58Prolonged bleeding time (HP:0003010)2.49736711
59Cellulitis (HP:0100658)2.47694069
60Pulmonary embolism (HP:0002204)2.47064832
61Peritonitis (HP:0002586)2.38971123
62Gingival bleeding (HP:0000225)2.38848268
63Hypergammaglobulinemia (HP:0010702)2.38705867
64Abnormality of the pleura (HP:0002103)2.31953201
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31583999
66Abnormality of polysaccharide metabolism (HP:0011012)2.31583999
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31583999
68Premature loss of primary teeth (HP:0006323)2.30969167
69Abnormality of iron homeostasis (HP:0011031)2.29766702
70Inflammation of the large intestine (HP:0002037)2.28861953
71Hepatosplenomegaly (HP:0001433)2.27759971
72Amaurosis fugax (HP:0100576)2.25180779
73Mutism (HP:0002300)2.25176530
74Polyneuropathy (HP:0001271)2.23210746
75Abnormality of the endocardium (HP:0004306)2.22246716
76Epistaxis (HP:0000421)2.22063366
77Hypochromic microcytic anemia (HP:0004840)2.19701517
78Colitis (HP:0002583)2.18445412
79Vertigo (HP:0002321)2.18416269
80Gastrointestinal inflammation (HP:0004386)2.17488119
81Mucopolysacchariduria (HP:0008155)2.16850496
82Urinary glycosaminoglycan excretion (HP:0003541)2.16850496
83Hypochromic anemia (HP:0001931)2.11314880
84Malnutrition (HP:0004395)2.09630931
85Glomerulopathy (HP:0100820)2.09330929
86Abnormality of the pericardium (HP:0001697)2.08919353
87Osteomyelitis (HP:0002754)2.08518857
88Progressive neurologic deterioration (HP:0002344)2.07858583
89Hypertensive crisis (HP:0100735)2.07762707
90Granulocytopenia (HP:0001913)2.07311155
91Acne (HP:0001061)2.05292968
92Pustule (HP:0200039)2.03785244
93Chronic otitis media (HP:0000389)2.02736215
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00406300
95Interstitial pulmonary disease (HP:0006530)1.99393383
96Keratitis (HP:0000491)1.98693090
97Abnormality of T cells (HP:0002843)1.97998044
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96410120
99Sepsis (HP:0100806)1.94571591
100Autoimmune hemolytic anemia (HP:0001890)1.93438201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.52790045
2TYK23.16805759
3IRAK43.07241054
4BLK3.02630708
5IRAK32.99099344
6MAP4K12.90207798
7CSK2.78593930
8MAP2K32.54536752
9MAP3K142.52794075
10GRK72.48466096
11PRPF4B2.43380792
12MATK2.35858792
13FGR2.32882509
14ERN12.30601142
15TAOK12.10153833
16TBK12.09955770
17JAK32.01377636
18MAP3K31.91852900
19IKBKE1.91338520
20ZAP701.90700080
21MAP3K111.86369495
22TAOK21.81928324
23TXK1.79238021
24FES1.75210917
25TNK21.64889339
26MAP3K131.60420131
27EPHB11.58513531
28IKBKB1.52289496
29JAK11.48978291
30SYK1.42815785
31SIK31.41411127
32HCK1.40313473
33JAK21.37562277
34LYN1.37320432
35MAP3K11.35885705
36BTK1.34094625
37GRK61.27888631
38DDR21.23175377
39BMPR21.21768074
40IRAK11.17876814
41CDC42BPA1.11806805
42KIT1.07480908
43IRAK21.06501508
44CSF1R1.03993645
45MARK31.02165590
46RIPK11.01514517
47LCK1.01467457
48TGFBR20.99323570
49KSR20.98296588
50TAOK30.97388600
51ADRBK20.91488474
52MOS0.89465249
53EPHA30.81319505
54YES10.78886999
55MAP3K50.78499923
56NME20.76620058
57TESK20.74862701
58STK100.74086411
59PDK10.70120075
60MARK20.70008700
61SIK20.69746359
62DAPK20.69709318
63FGFR40.68038715
64PDPK10.67866128
65CHUK0.65388570
66PRKD20.61446781
67ITK0.59222429
68ACVR1B0.59060507
69FYN0.52968949
70TEC0.50043456
71SIK10.48842083
72MAP3K60.46588436
73MAPK70.46298550
74HIPK20.45059600
75PIM10.44895279
76FGFR30.44124593
77RPS6KC10.42649762
78RPS6KL10.42649762
79PTK60.39696607
80MAP2K60.38867048
81DYRK1B0.37802725
82TYRO30.36127179
83RPS6KA60.33851024
84MAPK120.33652402
85PIM20.33548455
86ARAF0.33460289
87KSR10.32720589
88DYRK30.32246989
89ABL10.31480677
90TRIB30.31357441
91PRKCD0.29796623
92SGK30.28276140
93PRKCQ0.27903590
94MAPK40.26986586
95MAPKAPK20.26921946
96CAMKK20.25426788
97CLK10.24911371
98CDK60.24772323
99BMX0.24215075
100MAP2K40.23488811

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.94952046
2* Osteoclast differentiation_Homo sapiens_hsa043802.93908925
3Allograft rejection_Homo sapiens_hsa053302.88801168
4Staphylococcus aureus infection_Homo sapiens_hsa051502.80405138
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.78556046
6Graft-versus-host disease_Homo sapiens_hsa053322.61774697
7Autoimmune thyroid disease_Homo sapiens_hsa053202.35534199
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.25312569
9Tuberculosis_Homo sapiens_hsa051522.24107368
10Malaria_Homo sapiens_hsa051442.15107657
11African trypanosomiasis_Homo sapiens_hsa051432.13972129
12Type I diabetes mellitus_Homo sapiens_hsa049402.13305482
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.12985381
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11782847
15Legionellosis_Homo sapiens_hsa051342.01960764
16Rheumatoid arthritis_Homo sapiens_hsa053231.98777759
17Asthma_Homo sapiens_hsa053101.95525452
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94144817
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.88930952
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84682771
21Other glycan degradation_Homo sapiens_hsa005111.79167777
22TNF signaling pathway_Homo sapiens_hsa046681.77671135
23B cell receptor signaling pathway_Homo sapiens_hsa046621.76003959
24Pertussis_Homo sapiens_hsa051331.71063480
25Toxoplasmosis_Homo sapiens_hsa051451.69259938
26Influenza A_Homo sapiens_hsa051641.68419899
27Chemokine signaling pathway_Homo sapiens_hsa040621.65951320
28Antigen processing and presentation_Homo sapiens_hsa046121.63086091
29Measles_Homo sapiens_hsa051621.62487158
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62314534
31Lysosome_Homo sapiens_hsa041421.57336334
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56019707
33Viral myocarditis_Homo sapiens_hsa054161.53912159
34Hematopoietic cell lineage_Homo sapiens_hsa046401.51235051
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49987054
36Phagosome_Homo sapiens_hsa041451.44190621
37Herpes simplex infection_Homo sapiens_hsa051681.42339993
38Salmonella infection_Homo sapiens_hsa051321.39781058
39Primary immunodeficiency_Homo sapiens_hsa053401.38922846
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.34146409
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33714567
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28784210
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26868227
44Acute myeloid leukemia_Homo sapiens_hsa052211.25892913
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19064551
46Hepatitis C_Homo sapiens_hsa051601.13494822
47T cell receptor signaling pathway_Homo sapiens_hsa046601.11857572
48Shigellosis_Homo sapiens_hsa051311.10529499
49Hepatitis B_Homo sapiens_hsa051611.09474367
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.03841374
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96948351
52Apoptosis_Homo sapiens_hsa042100.91970040
53Amoebiasis_Homo sapiens_hsa051460.82987317
54Prolactin signaling pathway_Homo sapiens_hsa049170.79650137
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75661155
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75315451
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.75215274
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.73337487
59VEGF signaling pathway_Homo sapiens_hsa043700.70485463
60Epstein-Barr virus infection_Homo sapiens_hsa051690.69902555
61Platelet activation_Homo sapiens_hsa046110.69655614
62Pancreatic cancer_Homo sapiens_hsa052120.64385097
63Collecting duct acid secretion_Homo sapiens_hsa049660.61768634
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61622500
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61523114
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.60776921
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.60679673
68Bladder cancer_Homo sapiens_hsa052190.60314153
69Chronic myeloid leukemia_Homo sapiens_hsa052200.57019064
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56940577
71Endocytosis_Homo sapiens_hsa041440.54824867
72Non-small cell lung cancer_Homo sapiens_hsa052230.54317236
73Type II diabetes mellitus_Homo sapiens_hsa049300.51500003
74Renal cell carcinoma_Homo sapiens_hsa052110.51279637
75Notch signaling pathway_Homo sapiens_hsa043300.47668074
76Prion diseases_Homo sapiens_hsa050200.46632439
77HIF-1 signaling pathway_Homo sapiens_hsa040660.45539774
78Viral carcinogenesis_Homo sapiens_hsa052030.44156459
79HTLV-I infection_Homo sapiens_hsa051660.42704246
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.42597065
81Dorso-ventral axis formation_Homo sapiens_hsa043200.41846555
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41028207
83FoxO signaling pathway_Homo sapiens_hsa040680.37753542
84GnRH signaling pathway_Homo sapiens_hsa049120.36501103
85Insulin resistance_Homo sapiens_hsa049310.33489551
86Complement and coagulation cascades_Homo sapiens_hsa046100.31977507
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31592220
88MAPK signaling pathway_Homo sapiens_hsa040100.30258673
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29973330
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27974124
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26041032
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22997901
93Endometrial cancer_Homo sapiens_hsa052130.22236122
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21929058
95Mineral absorption_Homo sapiens_hsa049780.20410744
96Rap1 signaling pathway_Homo sapiens_hsa040150.19712958
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19679610
98Choline metabolism in cancer_Homo sapiens_hsa052310.19229198
99mTOR signaling pathway_Homo sapiens_hsa041500.18878581
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16111918

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »