LILRA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.06371499
2B cell receptor signaling pathway (GO:0050853)6.04643157
3regulation of B cell receptor signaling pathway (GO:0050855)5.99634520
4immunoglobulin mediated immune response (GO:0016064)5.83009321
5positive regulation of gamma-delta T cell activation (GO:0046645)5.50809761
6antigen processing and presentation of endogenous antigen (GO:0019883)5.46365768
7regulation of antigen processing and presentation (GO:0002577)5.43782146
8defense response to protozoan (GO:0042832)5.08663962
9negative regulation of cell killing (GO:0031342)4.90117779
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.90117779
11neutrophil activation involved in immune response (GO:0002283)4.89654157
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.86400646
13regulation of interferon-beta biosynthetic process (GO:0045357)4.78456121
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.73302351
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.70244372
16positive thymic T cell selection (GO:0045059)4.68640155
17regulation of dendritic cell antigen processing and presentation (GO:0002604)4.62190721
18regulation of B cell differentiation (GO:0045577)4.57071748
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.50924915
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.50924915
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.50924915
22modulation by symbiont of host immune response (GO:0052553)4.50924915
23positive regulation by symbiont of host defense response (GO:0052509)4.50924915
24modulation by symbiont of host defense response (GO:0052031)4.50924915
25B cell mediated immunity (GO:0019724)4.47705543
26positive regulation of B cell differentiation (GO:0045579)4.38303420
27response to protozoan (GO:0001562)4.38035389
28macrophage activation involved in immune response (GO:0002281)4.36916755
29interferon-gamma-mediated signaling pathway (GO:0060333)4.27505148
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.27134783
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19550676
32positive regulation of antigen processing and presentation (GO:0002579)4.15992262
33regulation of gamma-delta T cell activation (GO:0046643)4.01328462
34detection of bacterium (GO:0016045)4.00133144
35positive regulation of type 2 immune response (GO:0002830)3.99335278
36type I interferon signaling pathway (GO:0060337)3.91361768
37cellular response to type I interferon (GO:0071357)3.91361768
38negative thymic T cell selection (GO:0045060)3.90320441
39positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.88972442
40regulation of germinal center formation (GO:0002634)3.88431339
41response to type I interferon (GO:0034340)3.87565508
42detection of other organism (GO:0098543)3.86966779
43respiratory burst (GO:0045730)3.85236205
44negative T cell selection (GO:0043383)3.79590399
45positive T cell selection (GO:0043368)3.76211437
46antigen receptor-mediated signaling pathway (GO:0050851)3.74127735
47T cell selection (GO:0045058)3.72481366
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.70723505
49thymic T cell selection (GO:0045061)3.70378175
50production of molecular mediator involved in inflammatory response (GO:0002532)3.63260257
51regulation of mast cell degranulation (GO:0043304)3.63146258
52neutrophil activation (GO:0042119)3.62746373
53regulation of gamma-delta T cell differentiation (GO:0045586)3.61777804
54positive regulation of interferon-alpha production (GO:0032727)3.56041309
55T cell costimulation (GO:0031295)3.55638828
56positive regulation of mast cell activation (GO:0033005)3.50693656
57lymphocyte costimulation (GO:0031294)3.50392477
58myeloid cell activation involved in immune response (GO:0002275)3.47831976
59regulation of interferon-alpha production (GO:0032647)3.46683961
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.43848577
61positive regulation of mast cell degranulation (GO:0043306)3.43848577
62positive regulation of B cell proliferation (GO:0030890)3.42767946
63response to peptidoglycan (GO:0032494)3.38099242
64B cell homeostasis (GO:0001782)3.36278725
65granulocyte activation (GO:0036230)3.35412400
66positive regulation of B cell activation (GO:0050871)3.35362289
67regulation of mast cell activation involved in immune response (GO:0033006)3.34470347
68regulation of mast cell activation (GO:0033003)3.34458373
69leukocyte aggregation (GO:0070486)3.34056000
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32539150
71regulation of T-helper 2 cell differentiation (GO:0045628)3.29509281
72CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.28400318
73regulation of B cell proliferation (GO:0030888)3.24681245
74negative regulation of lymphocyte mediated immunity (GO:0002707)3.23081782
75regulation of type 2 immune response (GO:0002828)3.22811809
76negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.22238321
77negative regulation of T-helper cell differentiation (GO:0045623)3.22238321
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22215098
79regulation of interferon-gamma biosynthetic process (GO:0045072)3.21755388
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19877883
81negative regulation of alpha-beta T cell activation (GO:0046636)3.17550858
82B cell proliferation (GO:0042100)3.10635787
83cellular response to interferon-gamma (GO:0071346)3.10321251
84microglial cell activation (GO:0001774)3.09390315
85cellular response to interleukin-15 (GO:0071350)3.07236428
86Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07191506
87positive regulation of interferon-gamma production (GO:0032729)3.04897517
88response to host immune response (GO:0052572)3.04024605
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04024605
90detection of external biotic stimulus (GO:0098581)3.03450344
91positive regulation of granulocyte differentiation (GO:0030854)3.01823192
92positive regulation of humoral immune response (GO:0002922)3.00988998
93regulation of alpha-beta T cell proliferation (GO:0046640)3.00328937
94regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99353159
95regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.99326502
96hydrogen peroxide biosynthetic process (GO:0050665)2.98756565
97T cell migration (GO:0072678)2.96964679
98regulation of B cell activation (GO:0050864)2.92023339
99regulation of T-helper 1 cell differentiation (GO:0045625)2.89995980
100response to interleukin-15 (GO:0070672)2.89442995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.44719870
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.77593125
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.07065318
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87454076
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61684034
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.53051589
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.52094711
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31728566
9MYC_22102868_ChIP-Seq_BL_Human3.30651619
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.24259346
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.09467924
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.95057660
13SCL_19346495_ChIP-Seq_HPC-7_Human2.88483095
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71511511
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70757869
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64450963
17RUNX_20019798_ChIP-Seq_JUKART_Human2.60892020
18MYB_26560356_Chip-Seq_TH2_Human2.57872217
19* SPI1_23547873_ChIP-Seq_NB4_Human2.57523305
20VDR_21846776_ChIP-Seq_THP-1_Human2.54912853
21MAF_26560356_Chip-Seq_TH1_Human2.36730818
22VDR_24763502_ChIP-Seq_THP-1_Human2.31743652
23SPI1_23127762_ChIP-Seq_K562_Human2.31701527
24UTX_26944678_Chip-Seq_JUKART_Human2.24050021
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20860276
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20716656
27MYB_26560356_Chip-Seq_TH1_Human2.18686444
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13668013
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13613692
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09755994
31CIITA_25753668_ChIP-Seq_RAJI_Human2.01838500
32IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00333367
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.99901457
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97202656
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94264710
36GATA3_27048872_Chip-Seq_THYMUS_Human1.81038888
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80386897
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79251119
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77634470
40MAF_26560356_Chip-Seq_TH2_Human1.76307698
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71946497
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68125343
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67606564
44GATA1_22025678_ChIP-Seq_K562_Human1.65351929
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65178569
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58904809
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58213016
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51526456
49GATA3_26560356_Chip-Seq_TH2_Human1.49371550
50TCF7_22412390_ChIP-Seq_EML_Mouse1.47534501
51KDM2B_26808549_Chip-Seq_DND41_Human1.44117519
52BCL6_27268052_Chip-Seq_Bcells_Human1.42674631
53VDR_24787735_ChIP-Seq_THP-1_Human1.41933574
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38383698
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34649447
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.31963659
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.28297195
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26438071
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24796630
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24751882
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23735606
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23338835
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22858524
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20762147
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.18624318
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17973914
67BCOR_27268052_Chip-Seq_Bcells_Human1.17345183
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17270699
69EZH2_22144423_ChIP-Seq_EOC_Human1.14676116
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13450966
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12698809
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11989770
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11738382
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10730901
75* P300_27268052_Chip-Seq_Bcells_Human1.10671756
76LXR_22292898_ChIP-Seq_THP-1_Human1.06584049
77SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.05343643
78SMRT_27268052_Chip-Seq_Bcells_Human1.05129308
79* ELF1_20517297_ChIP-Seq_JURKAT_Human1.04679090
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03782461
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02647287
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01236337
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99786038
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99584789
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99258111
86GATA1_19941826_ChIP-Seq_K562_Human0.98004750
87SPI1_20517297_ChIP-Seq_HL60_Human0.97726138
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96990156
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96966461
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94653350
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93379568
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91328407
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91060318
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90693255
95PU_27001747_Chip-Seq_BMDM_Mouse0.87910034
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85407402
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83611428
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82025302
99STAT1_20625510_ChIP-Seq_HELA_Human0.81407816
100EGR1_19032775_ChIP-ChIP_M12_Human0.77818036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.98254677
2MP0001800_abnormal_humoral_immune3.92980484
3MP0005387_immune_system_phenotype3.86153078
4MP0001790_abnormal_immune_system3.86153078
5MP0005671_abnormal_response_to3.76286434
6MP0003303_peritoneal_inflammation3.64937756
7MP0002452_abnormal_antigen_presenting3.19954025
8MP0000685_abnormal_immune_system3.18713225
9MP0002723_abnormal_immune_serum3.14146315
10MP0005000_abnormal_immune_tolerance3.12251741
11MP0003724_increased_susceptibility_to3.10221697
12MP0003436_decreased_susceptibility_to3.09804035
13MP0002420_abnormal_adaptive_immunity2.98317687
14MP0001819_abnormal_immune_cell2.93001666
15MP0009785_altered_susceptibility_to2.89896699
16MP0005025_abnormal_response_to2.87184146
17MP0002419_abnormal_innate_immunity2.77067659
18MP0003763_abnormal_thymus_physiology2.73633077
19MP0002148_abnormal_hypersensitivity_rea2.61891493
20MP0002398_abnormal_bone_marrow2.39996427
21MP0000716_abnormal_immune_system2.30157373
22MP0006082_CNS_inflammation2.24385094
23MP0002405_respiratory_system_inflammati2.10362821
24MP0000689_abnormal_spleen_morphology2.08711321
25MP0005310_abnormal_salivary_gland1.95849050
26MP0003172_abnormal_lysosome_physiology1.90894936
27MP0005464_abnormal_platelet_physiology1.87494075
28MP0003183_abnormal_peptide_metabolism1.82099742
29MP0005075_abnormal_melanosome_morpholog1.81920130
30MP0002429_abnormal_blood_cell1.81377731
31MP0002722_abnormal_immune_system1.78470834
32MP0003191_abnormal_cellular_cholesterol1.78145788
33MP0010155_abnormal_intestine_physiology1.74921406
34MP0001845_abnormal_inflammatory_respons1.67738712
35MP0003300_gastrointestinal_ulcer1.65849136
36MP0004381_abnormal_hair_follicle1.53605543
37MP0001873_stomach_inflammation1.51525912
38MP0005058_abnormal_lysosome_morphology1.46523444
39MP0002138_abnormal_hepatobiliary_system1.45158106
40MP0000703_abnormal_thymus_morphology1.43766949
41MP0008469_abnormal_protein_level1.41991551
42MP0000465_gastrointestinal_hemorrhage1.41125096
43MP0001533_abnormal_skeleton_physiology1.39056782
44MP0009333_abnormal_splenocyte_physiolog1.38051801
45MP0003866_abnormal_defecation1.33113088
46MP0009278_abnormal_bone_marrow1.31479672
47MP0001853_heart_inflammation1.31389642
48MP0009764_decreased_sensitivity_to1.28537318
49MP0004947_skin_inflammation1.21576575
50MP0003787_abnormal_imprinting1.16809747
51MP0001348_abnormal_lacrimal_gland1.13438730
52MP0008004_abnormal_stomach_pH1.11717699
53MP0003075_altered_response_to1.11655662
54MP0005166_decreased_susceptibility_to1.01677320
55MP0002166_altered_tumor_susceptibility1.00603937
56MP0001545_abnormal_hematopoietic_system0.98243503
57MP0005397_hematopoietic_system_phenotyp0.98243503
58MP0002933_joint_inflammation0.97464038
59MP0004883_abnormal_blood_vessel0.94404665
60MP0002396_abnormal_hematopoietic_system0.93028668
61MP0005645_abnormal_hypothalamus_physiol0.92207389
62MP0003690_abnormal_glial_cell0.92206793
63MP0004510_myositis0.90412008
64MP0000858_altered_metastatic_potential0.90337443
65MP0002132_abnormal_respiratory_system0.86954220
66MP0001851_eye_inflammation0.85604658
67MP0005451_abnormal_body_composition0.84781810
68MP0002928_abnormal_bile_duct0.83723475
69MP0001663_abnormal_digestive_system0.81848192
70MP0000015_abnormal_ear_pigmentation0.80611783
71MP0000490_abnormal_crypts_of0.80221589
72MP0002009_preneoplasia0.77015656
73MP0002653_abnormal_ependyma_morphology0.76218938
74MP0009840_abnormal_foam_cell0.72941922
75MP0002998_abnormal_bone_remodeling0.70813686
76MP0000343_altered_response_to0.69634528
77MP0000249_abnormal_blood_vessel0.68432530
78MP0002006_tumorigenesis0.63820690
79MP0002019_abnormal_tumor_incidence0.62137807
80MP0008874_decreased_physiological_sensi0.61533333
81MP0002693_abnormal_pancreas_physiology0.60118620
82MP0003045_fibrosis0.59660984
83MP0003656_abnormal_erythrocyte_physiolo0.59407199
84MP0009763_increased_sensitivity_to0.59274325
85MP0008961_abnormal_basal_metabolism0.58513466
86MP0003252_abnormal_bile_duct0.57677214
87MP0008877_abnormal_DNA_methylation0.57672582
88MP0005174_abnormal_tail_pigmentation0.57554625
89MP0004142_abnormal_muscle_tone0.54291560
90MP0005584_abnormal_enzyme/coenzyme_acti0.51925956
91MP0003828_pulmonary_edema0.51389989
92MP0002277_abnormal_respiratory_mucosa0.50930005
93MP0005535_abnormal_body_temperature0.49705880
94MP0001986_abnormal_taste_sensitivity0.49580752
95MP0002163_abnormal_gland_morphology0.49273968
96MP0005381_digestive/alimentary_phenotyp0.46212789
97MP0005390_skeleton_phenotype0.45387415
98MP0005164_abnormal_response_to0.42981660
99MP0003091_abnormal_cell_migration0.42848185
100MP0006036_abnormal_mitochondrial_physio0.42489058

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.87217945
2Eczematoid dermatitis (HP:0000976)5.88571239
3Meningitis (HP:0001287)5.60683197
4Recurrent bacterial skin infections (HP:0005406)5.59713828
5Cellulitis (HP:0100658)5.22533335
6Recurrent abscess formation (HP:0002722)5.11853426
7Mediastinal lymphadenopathy (HP:0100721)4.90300505
8Abnormality of macrophages (HP:0004311)4.84401675
9Recurrent fungal infections (HP:0002841)4.65262959
10Chronic obstructive pulmonary disease (HP:0006510)4.63317830
11Obstructive lung disease (HP:0006536)4.63317830
12Recurrent gram-negative bacterial infections (HP:0005420)4.51261418
13Recurrent bronchitis (HP:0002837)4.37461143
14Papilloma (HP:0012740)4.20376267
15Verrucae (HP:0200043)4.20376267
16Chronic mucocutaneous candidiasis (HP:0002728)4.11633554
17Recurrent cutaneous fungal infections (HP:0011370)4.11633554
18Recurrent pneumonia (HP:0006532)4.03498452
19Panhypogammaglobulinemia (HP:0003139)4.01901882
20Recurrent skin infections (HP:0001581)4.01192979
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.97874917
22Colitis (HP:0002583)3.95868329
23Vasculitis (HP:0002633)3.91477436
24Inflammation of the large intestine (HP:0002037)3.87349412
25Gastrointestinal stroma tumor (HP:0100723)3.87136022
26Recurrent viral infections (HP:0004429)3.87041215
27Osteomyelitis (HP:0002754)3.78476002
28Gastrointestinal inflammation (HP:0004386)3.72848614
29Stomatitis (HP:0010280)3.64662354
30Myositis (HP:0100614)3.63873494
31Recurrent sinusitis (HP:0011108)3.58248260
32Sepsis (HP:0100806)3.57770955
33Increased IgE level (HP:0003212)3.52973245
34Elevated erythrocyte sedimentation rate (HP:0003565)3.52219185
35Encephalitis (HP:0002383)3.49329228
36Recurrent lower respiratory tract infections (HP:0002783)3.44683498
37Chronic sinusitis (HP:0011109)3.42712231
38Optic neuritis (HP:0100653)3.38616635
39Retrobulbar optic neuritis (HP:0100654)3.38616635
40Urticaria (HP:0001025)3.30750634
41Pulmonary infiltrates (HP:0002113)3.28668263
42Orchitis (HP:0100796)3.25159404
43Gastrointestinal infarctions (HP:0005244)3.24868708
44Lymphopenia (HP:0001888)3.19794385
45Skin rash (HP:0000988)3.06441152
46Prolonged bleeding time (HP:0003010)2.94104593
47Abnormality of the prostate (HP:0008775)2.90012349
48IgM deficiency (HP:0002850)2.87440239
49Abnormality of B cell number (HP:0010975)2.86839213
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.84927436
51Restrictive lung disease (HP:0002091)2.83981513
52Chest pain (HP:0100749)2.78574334
53B lymphocytopenia (HP:0010976)2.77838784
54Hemoptysis (HP:0002105)2.74083499
55Pulmonary fibrosis (HP:0002206)2.67006559
56IgG deficiency (HP:0004315)2.65217522
57Bronchitis (HP:0012387)2.63220944
58Abnormality of the pleura (HP:0002103)2.59256459
59Petechiae (HP:0000967)2.49330690
60Increased IgM level (HP:0003496)2.48695096
61Epistaxis (HP:0000421)2.48245542
62Gingivitis (HP:0000230)2.45861527
63Skin ulcer (HP:0200042)2.43097514
64Keratoconjunctivitis (HP:0001096)2.40721220
65Abnormality of T cells (HP:0002843)2.40457340
66Keratoconjunctivitis sicca (HP:0001097)2.40280704
67Hypertensive crisis (HP:0100735)2.39331884
68Chronic otitis media (HP:0000389)2.37793081
69T lymphocytopenia (HP:0005403)2.33080226
70Autoimmune thrombocytopenia (HP:0001973)2.28190765
71Abnormality of T cell physiology (HP:0011840)2.28094417
72Pulmonary embolism (HP:0002204)2.28022336
73Lymphoma (HP:0002665)2.27979246
74Viral hepatitis (HP:0006562)2.27675983
75Gangrene (HP:0100758)2.26995048
76Abnormality of T cell number (HP:0011839)2.26936211
77Spontaneous hematomas (HP:0007420)2.25262282
78Abnormality of the peritoneum (HP:0002585)2.24328404
79Granulocytopenia (HP:0001913)2.22271340
80Severe combined immunodeficiency (HP:0004430)2.22012279
81Leukocytosis (HP:0001974)2.17551045
82Pustule (HP:0200039)2.16464785
83Emphysema (HP:0002097)2.15435131
84Recurrent otitis media (HP:0000403)2.13183917
85Hypergammaglobulinemia (HP:0010702)2.11239394
86Eosinophilia (HP:0001880)2.05907244
87Xerostomia (HP:0000217)2.05411777
88Polyneuropathy (HP:0001271)2.01635045
89Episodic fever (HP:0001954)2.01504235
90Dysostosis multiplex (HP:0000943)2.00503965
91Gingival bleeding (HP:0000225)1.99636048
92Hematochezia (HP:0002573)1.98082490
93Arthralgia (HP:0002829)1.96311979
94Purpura (HP:0000979)1.93911385
95Autoimmune hemolytic anemia (HP:0001890)1.91849359
96Arterial thrombosis (HP:0004420)1.86809061
97Abnormality of eosinophils (HP:0001879)1.84823138
98Neutropenia (HP:0001875)1.82027246
99Albinism (HP:0001022)1.81069771
100Abnormality of male internal genitalia (HP:0000022)1.79829144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.41617446
2RIPK44.85664125
3BLK3.82973285
4TXK3.23731381
5BMPR22.99507137
6IRAK42.98662794
7TYK22.80277672
8CSF1R2.46195373
9SYK2.28741097
10MAP3K112.27897027
11GRK62.15073875
12BTK2.03094601
13ERN11.98399722
14IKBKE1.84632629
15LYN1.82181496
16KIT1.69332407
17CSK1.69020784
18TBK11.68263810
19TNK21.62947880
20FES1.62348486
21SIK21.60346277
22SIK31.60260571
23IKBKB1.57472839
24PRPF4B1.56645715
25MAP2K31.50721457
26ZAP701.48228833
27TAOK31.45393809
28TESK21.40209919
29GRK71.37962303
30JAK31.33570356
31HCK1.32272075
32MAPK121.31014031
33LCK1.28541826
34MARK31.24819787
35JAK11.22471858
36MAP3K131.19997899
37MAP3K31.18851484
38MAP3K141.17532023
39TAOK11.02706935
40PRKCQ0.99373333
41ITK0.96823794
42STK100.95994143
43JAK20.95421773
44MAPK150.95379664
45MATK0.94561471
46FGR0.90546272
47TEC0.86470334
48MAP3K120.82061367
49MAP3K100.80753450
50TAOK20.80133993
51FYN0.78690750
52PDK10.78570211
53TGFBR20.78150852
54KDR0.75728906
55PIM10.75072552
56PKN10.74864548
57MAPK110.74282398
58MARK20.70774179
59IRAK20.66254409
60MAP3K10.65029309
61CDK190.64793834
62PIK3CG0.64374640
63EPHB10.63486830
64PRKD20.60522611
65CDC42BPA0.59100962
66RPS6KA40.56327380
67MAP3K50.55047623
68DYRK1B0.54660302
69LRRK20.53207082
70MAPK40.52721141
71MAPK130.51609487
72SIK10.49717571
73PRKD10.49461768
74CDK40.48650228
75MAPKAPK20.47713158
76FLT30.46201556
77HIPK20.45294383
78PASK0.42529725
79PDPK10.41939344
80MOS0.38749354
81IRAK10.38676121
82ADRBK20.38194513
83STK110.33449780
84CHUK0.33217992
85PRKCD0.31471058
86RPS6KA10.30645410
87MAPK70.30536898
88ABL10.29480709
89MAP3K70.29476213
90NLK0.28922083
91PRKCZ0.25988556
92MAP2K20.24060197
93NTRK30.22979997
94EGFR0.22655802
95INSR0.22324098
96ILK0.22135974
97GRK50.20816653
98CAMKK10.20487173
99DAPK10.20247746
100MAPK30.18941479

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.47539813
2Asthma_Homo sapiens_hsa053104.45208006
3Autoimmune thyroid disease_Homo sapiens_hsa053204.35304055
4Graft-versus-host disease_Homo sapiens_hsa053324.26644901
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.84091089
6Type I diabetes mellitus_Homo sapiens_hsa049403.54376238
7Primary immunodeficiency_Homo sapiens_hsa053403.43918053
8Leishmaniasis_Homo sapiens_hsa051403.18961160
9Staphylococcus aureus infection_Homo sapiens_hsa051503.17186887
10Antigen processing and presentation_Homo sapiens_hsa046122.89050191
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.88891413
12B cell receptor signaling pathway_Homo sapiens_hsa046622.81505148
13Viral myocarditis_Homo sapiens_hsa054162.58275712
14Tuberculosis_Homo sapiens_hsa051521.95410661
15Rheumatoid arthritis_Homo sapiens_hsa053231.89110299
16Hematopoietic cell lineage_Homo sapiens_hsa046401.89109193
17* Osteoclast differentiation_Homo sapiens_hsa043801.88989863
18Toxoplasmosis_Homo sapiens_hsa051451.75369899
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.62387765
20Herpes simplex infection_Homo sapiens_hsa051681.60429407
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58636980
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57411562
23Influenza A_Homo sapiens_hsa051641.52912691
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30196282
25Phagosome_Homo sapiens_hsa041451.29127629
26T cell receptor signaling pathway_Homo sapiens_hsa046601.27807212
27Measles_Homo sapiens_hsa051621.20104176
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16936520
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15896143
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10511539
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06555779
32NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96347402
33Jak-STAT signaling pathway_Homo sapiens_hsa046300.95700186
34Chemokine signaling pathway_Homo sapiens_hsa040620.94223373
35Epstein-Barr virus infection_Homo sapiens_hsa051690.92604008
36Malaria_Homo sapiens_hsa051440.91810133
37Systemic lupus erythematosus_Homo sapiens_hsa053220.86481442
38Pertussis_Homo sapiens_hsa051330.79129697
39African trypanosomiasis_Homo sapiens_hsa051430.76842726
40TNF signaling pathway_Homo sapiens_hsa046680.76781742
41Acute myeloid leukemia_Homo sapiens_hsa052210.72042479
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71448570
43HTLV-I infection_Homo sapiens_hsa051660.70261636
44Hepatitis B_Homo sapiens_hsa051610.70085072
45Legionellosis_Homo sapiens_hsa051340.69812331
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67981708
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63554963
48Platelet activation_Homo sapiens_hsa046110.63546692
49Shigellosis_Homo sapiens_hsa051310.58103385
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.51794374
51Non-small cell lung cancer_Homo sapiens_hsa052230.48080043
52Hepatitis C_Homo sapiens_hsa051600.47896345
53Apoptosis_Homo sapiens_hsa042100.45733277
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43594680
55Salmonella infection_Homo sapiens_hsa051320.42561660
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42552552
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.40266666
58Viral carcinogenesis_Homo sapiens_hsa052030.38691319
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35308806
60Other glycan degradation_Homo sapiens_hsa005110.34151527
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.32512689
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.31936039
63VEGF signaling pathway_Homo sapiens_hsa043700.31873800
64Endocytosis_Homo sapiens_hsa041440.31419178
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30824499
66Lysosome_Homo sapiens_hsa041420.30319859
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26383710
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.25437856
69MAPK signaling pathway_Homo sapiens_hsa040100.25182478
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22626595
71Inositol phosphate metabolism_Homo sapiens_hsa005620.22604359
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.18307531
73Pancreatic cancer_Homo sapiens_hsa052120.17906100
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17859145
75Colorectal cancer_Homo sapiens_hsa052100.15422236
76Notch signaling pathway_Homo sapiens_hsa043300.13712940
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.13466515
78Renal cell carcinoma_Homo sapiens_hsa052110.13298364
79Morphine addiction_Homo sapiens_hsa050320.12297086
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11370521
81Collecting duct acid secretion_Homo sapiens_hsa049660.11190290
82FoxO signaling pathway_Homo sapiens_hsa040680.10610905
83Chronic myeloid leukemia_Homo sapiens_hsa052200.09178602
84Dorso-ventral axis formation_Homo sapiens_hsa043200.08851974
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08661980
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08493198
87Choline metabolism in cancer_Homo sapiens_hsa052310.08073337
88Olfactory transduction_Homo sapiens_hsa047400.07617901
89Regulation of autophagy_Homo sapiens_hsa041400.07523556
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05463521
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05432789
92Rap1 signaling pathway_Homo sapiens_hsa040150.05240633
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05143337
94GnRH signaling pathway_Homo sapiens_hsa049120.05033359
95Ras signaling pathway_Homo sapiens_hsa040140.04886725
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.04878526
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04459607
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04190442
99Ether lipid metabolism_Homo sapiens_hsa005650.03778868
100mTOR signaling pathway_Homo sapiens_hsa041500.02245242

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