LILRA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.47949944
2respiratory burst (GO:0045730)5.80870554
3leukocyte aggregation (GO:0070486)5.80770212
4response to peptidoglycan (GO:0032494)5.65073791
5cellular extravasation (GO:0045123)5.35650617
6positive regulation of mast cell activation (GO:0033005)5.27658848
7positive regulation of mast cell activation involved in immune response (GO:0033008)5.20006437
8positive regulation of mast cell degranulation (GO:0043306)5.20006437
9neutrophil activation (GO:0042119)5.14961647
10production of molecular mediator involved in inflammatory response (GO:0002532)5.07299244
11granulocyte activation (GO:0036230)4.94572699
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.87547751
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.87547751
14modulation by symbiont of host immune response (GO:0052553)4.87547751
15positive regulation by symbiont of host defense response (GO:0052509)4.87547751
16modulation by symbiont of host defense response (GO:0052031)4.87547751
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.87547751
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74214765
19immunoglobulin mediated immune response (GO:0016064)4.71660680
20hydrogen peroxide biosynthetic process (GO:0050665)4.46776507
21neutrophil mediated immunity (GO:0002446)4.36745383
22detection of external biotic stimulus (GO:0098581)4.36032809
23regulation of mast cell degranulation (GO:0043304)4.35631343
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25621140
25positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.19249691
26regulation of mast cell activation (GO:0033003)4.18930796
27response to host immune response (GO:0052572)4.18088266
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.18088266
29leukocyte migration involved in inflammatory response (GO:0002523)4.16165641
30superoxide anion generation (GO:0042554)4.13992487
31regulation of myeloid leukocyte mediated immunity (GO:0002886)4.09471509
32microglial cell activation (GO:0001774)4.09224644
33negative regulation of lymphocyte mediated immunity (GO:0002707)4.04518480
34regulation of B cell receptor signaling pathway (GO:0050855)4.04239286
35regulation of mast cell activation involved in immune response (GO:0033006)4.01651935
36positive regulation of interferon-alpha production (GO:0032727)4.00182646
37regulation of gamma-delta T cell activation (GO:0046643)3.99465677
38regulation of leukocyte degranulation (GO:0043300)3.98274281
39reactive oxygen species biosynthetic process (GO:1903409)3.97799433
40positive regulation of leukocyte degranulation (GO:0043302)3.95107283
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92060334
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91772619
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.89372652
44macrophage activation (GO:0042116)3.86693964
45positive regulation of monocyte chemotaxis (GO:0090026)3.85632969
46detection of biotic stimulus (GO:0009595)3.85503011
47regulation of interferon-alpha production (GO:0032647)3.79297412
48macrophage activation involved in immune response (GO:0002281)3.79038175
49neutrophil chemotaxis (GO:0030593)3.77142858
50response to host (GO:0075136)3.75546215
51response to host defenses (GO:0052200)3.75546215
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.75546215
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.67090238
54neutrophil migration (GO:1990266)3.66813667
55negative regulation of T cell mediated immunity (GO:0002710)3.64360263
56response to fungus (GO:0009620)3.61631560
57negative regulation of leukocyte mediated immunity (GO:0002704)3.57183559
58myeloid cell activation involved in immune response (GO:0002275)3.56436925
59positive regulation of antigen processing and presentation (GO:0002579)3.56003453
60response to muramyl dipeptide (GO:0032495)3.55664805
61leukocyte mediated cytotoxicity (GO:0001909)3.50675593
62B cell mediated immunity (GO:0019724)3.50212611
63eosinophil migration (GO:0072677)3.49877905
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48592586
65negative regulation of cell killing (GO:0031342)3.48592586
66positive regulation of gamma-delta T cell activation (GO:0046645)3.48279268
67antigen processing and presentation of endogenous antigen (GO:0019883)3.48071968
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.44733930
69interferon-gamma-mediated signaling pathway (GO:0060333)3.43680210
70granulocyte migration (GO:0097530)3.42887900
71Arp2/3 complex-mediated actin nucleation (GO:0034314)3.42114089
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41970963
73detection of other organism (GO:0098543)3.39888696
74response to interleukin-15 (GO:0070672)3.39188056
75positive regulation of cellular amide metabolic process (GO:0034250)3.38896854
76negative regulation of mast cell activation (GO:0033004)3.36463017
77type I interferon signaling pathway (GO:0060337)3.35184389
78cellular response to type I interferon (GO:0071357)3.35184389
79response to type I interferon (GO:0034340)3.31897523
80granulocyte chemotaxis (GO:0071621)3.31854736
81regulation of T cell tolerance induction (GO:0002664)3.31712419
82myeloid leukocyte mediated immunity (GO:0002444)3.31107089
83germinal center formation (GO:0002467)3.30321550
84positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30135907
85regulation of regulated secretory pathway (GO:1903305)3.27347717
86negative regulation of cytokine production involved in immune response (GO:0002719)3.26427860
87regulation of tolerance induction (GO:0002643)3.22299919
88T-helper 1 type immune response (GO:0042088)3.20933639
89defense response to protozoan (GO:0042832)3.17723817
90regulation of interferon-beta biosynthetic process (GO:0045357)3.17519926
91negative regulation of interleukin-12 production (GO:0032695)3.17007524
92leukocyte cell-cell adhesion (GO:0007159)3.15354627
93phagosome maturation (GO:0090382)3.15320973
94response to protozoan (GO:0001562)3.14255240
95defense response to fungus (GO:0050832)3.14101929
96cellular response to interleukin-15 (GO:0071350)3.13693046
97regulation of gamma-delta T cell differentiation (GO:0045586)3.13346475
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13178976
99leukocyte degranulation (GO:0043299)3.12918604
100regulation of monocyte chemotaxis (GO:0090025)3.10498018
101regulation of B cell differentiation (GO:0045577)3.09846231
102regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08268520
103leukotriene metabolic process (GO:0006691)3.07857707
104positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05844618
105antigen processing and presentation via MHC class Ib (GO:0002475)3.05568621
106cellular response to zinc ion (GO:0071294)3.04985407
107positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.03535150
108positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.01214743
109negative regulation of interleukin-6 production (GO:0032715)3.01023265
110myeloid dendritic cell differentiation (GO:0043011)3.00268705
111negative regulation of innate immune response (GO:0045824)2.99831256
112detection of bacterium (GO:0016045)2.99219360
113regulation of T cell mediated cytotoxicity (GO:0001914)2.99195130
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99033437
115myeloid leukocyte activation (GO:0002274)2.98685709
116regulation of T-helper 1 cell differentiation (GO:0045625)2.97516454
117killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.97266464
118disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.97266464
119detection of molecule of bacterial origin (GO:0032490)2.96403816
120positive regulation of type 2 immune response (GO:0002830)2.96129616
121regulation of antigen processing and presentation (GO:0002577)2.94956623
122negative regulation of myeloid cell apoptotic process (GO:0033033)2.94927996
123positive regulation of chemokine biosynthetic process (GO:0045080)2.94725620
124regulation of T-helper 2 cell differentiation (GO:0045628)2.94704749
125regulation of interleukin-12 biosynthetic process (GO:0045075)2.94395323
126negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93190945
127negative regulation of T-helper cell differentiation (GO:0045623)2.93190945
128negative regulation of alpha-beta T cell activation (GO:0046636)2.91811440
129myeloid dendritic cell activation (GO:0001773)2.89917464
130regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.89772301
131negative regulation of interleukin-1 production (GO:0032692)2.89726339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.96736348
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.44714238
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.92747887
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.55269721
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.23733107
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.92314155
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80095700
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.76870215
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72913160
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.51289219
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.40879171
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32398630
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.09837474
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97371822
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.90440058
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90418494
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.78298395
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.63148650
19SPI1_23547873_ChIP-Seq_NB4_Human2.58308210
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55228015
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30975487
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.14861796
23SCL_19346495_ChIP-Seq_HPC-7_Human2.10138123
24VDR_24763502_ChIP-Seq_THP-1_Human2.02446260
25MYB_26560356_Chip-Seq_TH2_Human1.92611014
26SPI1_23127762_ChIP-Seq_K562_Human1.91716946
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.89250360
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85056406
29MAF_26560356_Chip-Seq_TH1_Human1.84001443
30RUNX_20019798_ChIP-Seq_JUKART_Human1.81483236
31PU_27001747_Chip-Seq_BMDM_Mouse1.80874886
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.79147457
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77927155
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76745076
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76473754
36VDR_21846776_ChIP-Seq_THP-1_Human1.74998004
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70480890
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70322345
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57956939
40VDR_24787735_ChIP-Seq_THP-1_Human1.57909476
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52071409
42CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.51603920
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50741037
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50423595
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48996854
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47788868
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47757306
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47624297
49MYB_26560356_Chip-Seq_TH1_Human1.47474960
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36523148
51GATA3_27048872_Chip-Seq_THYMUS_Human1.36098092
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35172851
53* GATA3_26560356_Chip-Seq_TH2_Human1.31715973
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31650251
55UTX_26944678_Chip-Seq_JUKART_Human1.31632849
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.31181749
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29409395
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28938680
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26308425
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25257723
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24350861
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23671996
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23390502
64TCF7_22412390_ChIP-Seq_EML_Mouse1.18658886
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14147524
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13019343
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04489284
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.03927070
69MAF_26560356_Chip-Seq_TH2_Human1.03165978
70GATA1_22025678_ChIP-Seq_K562_Human1.01828622
71EGR1_19032775_ChIP-ChIP_M12_Human0.96495503
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95558701
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94846895
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93307545
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92048840
76ELK3_25401928_ChIP-Seq_HUVEC_Human0.91954007
77SPI1_20517297_ChIP-Seq_HL60_Human0.89551320
78GATA2_19941826_ChIP-Seq_K562_Human0.88002294
79ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86900851
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86396892
81MYC_22102868_ChIP-Seq_BL_Human0.84762486
82STAT1_20625510_ChIP-Seq_HELA_Human0.84758598
83GATA1_19941826_ChIP-Seq_K562_Human0.83627042
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83279379
85SMRT_27268052_Chip-Seq_Bcells_Human0.83264527
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82723913
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82192865
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82068641
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81671210
90KDM2B_26808549_Chip-Seq_DND41_Human0.80825517
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79011744
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78536213
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78077926
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.77455640
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76362385
96* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73286035
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72352736
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69235125
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69235125
100BCL6_27268052_Chip-Seq_Bcells_Human0.68895880
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.68532177
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67987128
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67873397
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.67093974
105LXR_22292898_ChIP-Seq_THP-1_Human0.65053347
106SOX2_20726797_ChIP-Seq_SW620_Human0.64744854
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64336266
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.63553729
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.59894353
110BCOR_27268052_Chip-Seq_Bcells_Human0.59242972
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.58974457
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.58974457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.98400708
2MP0009785_altered_susceptibility_to4.22855673
3MP0003303_peritoneal_inflammation4.21467682
4MP0001835_abnormal_antigen_presentation4.11842738
5MP0002148_abnormal_hypersensitivity_rea3.79615299
6MP0002419_abnormal_innate_immunity3.49274292
7MP0005000_abnormal_immune_tolerance3.28887590
8MP0005025_abnormal_response_to3.17654646
9MP0000685_abnormal_immune_system2.90329343
10MP0003724_increased_susceptibility_to2.86030902
11MP0001790_abnormal_immune_system2.77672109
12MP0005387_immune_system_phenotype2.77672109
13MP0005671_abnormal_response_to2.68990554
14MP0002452_abnormal_antigen_presenting2.63726328
15MP0009278_abnormal_bone_marrow2.61370295
16MP0001800_abnormal_humoral_immune2.58816276
17MP0002723_abnormal_immune_serum2.53089515
18MP0004510_myositis2.49276647
19MP0001533_abnormal_skeleton_physiology2.47663516
20MP0001853_heart_inflammation2.36335785
21MP0001819_abnormal_immune_cell2.33831493
22MP0006082_CNS_inflammation2.31036442
23MP0002420_abnormal_adaptive_immunity2.30531485
24MP0009764_decreased_sensitivity_to2.19188041
25MP0002405_respiratory_system_inflammati2.16349261
26MP0005464_abnormal_platelet_physiology2.10633251
27MP0001845_abnormal_inflammatory_respons2.06960300
28MP0000343_altered_response_to2.05760967
29MP0005167_abnormal_blood-brain_barrier1.99753177
30MP0005058_abnormal_lysosome_morphology1.99502222
31MP0003075_altered_response_to1.93373759
32MP0010155_abnormal_intestine_physiology1.74917449
33MP0008469_abnormal_protein_level1.73623989
34MP0005397_hematopoietic_system_phenotyp1.70182767
35MP0001545_abnormal_hematopoietic_system1.70182767
36MP0004947_skin_inflammation1.69646875
37MP0000716_abnormal_immune_system1.66703950
38MP0003183_abnormal_peptide_metabolism1.64461188
39MP0003448_altered_tumor_morphology1.64102244
40MP0002398_abnormal_bone_marrow1.59651978
41MP0003191_abnormal_cellular_cholesterol1.51420874
42MP0000858_altered_metastatic_potential1.44603564
43MP0002277_abnormal_respiratory_mucosa1.43289605
44MP0005310_abnormal_salivary_gland1.41688430
45MP0003806_abnormal_nucleotide_metabolis1.38454414
46MP0003300_gastrointestinal_ulcer1.36171584
47MP0009333_abnormal_splenocyte_physiolog1.34973616
48MP0002429_abnormal_blood_cell1.33405290
49MP0005166_decreased_susceptibility_to1.31458774
50MP0002933_joint_inflammation1.31090959
51MP0003828_pulmonary_edema1.30565709
52MP0000689_abnormal_spleen_morphology1.28218212
53MP0004883_abnormal_blood_vessel1.27979210
54MP0002006_tumorigenesis1.25308255
55MP0003172_abnormal_lysosome_physiology1.23893633
56MP0009840_abnormal_foam_cell1.20797739
57MP0005164_abnormal_response_to1.18748670
58MP0002998_abnormal_bone_remodeling1.16446310
59MP0002722_abnormal_immune_system1.15793447
60MP0005390_skeleton_phenotype1.15659037
61MP0001851_eye_inflammation1.15238276
62MP0008004_abnormal_stomach_pH1.14130685
63MP0005174_abnormal_tail_pigmentation1.11273701
64MP0009763_increased_sensitivity_to1.02874009
65MP0004381_abnormal_hair_follicle1.01914884
66MP0000604_amyloidosis0.99140651
67MP0000465_gastrointestinal_hemorrhage0.96673561
68MP0002166_altered_tumor_susceptibility0.93322511
69MP0000569_abnormal_digit_pigmentation0.92899460
70MP0004782_abnormal_surfactant_physiolog0.90892166
71MP0004808_abnormal_hematopoietic_stem0.89890969
72MP0000920_abnormal_myelination0.88757080
73MP0002837_dystrophic_cardiac_calcinosis0.86892528
74MP0005076_abnormal_cell_differentiation0.86824650
75MP0008260_abnormal_autophagy0.86719473
76MP0003690_abnormal_glial_cell0.84188093
77MP0002138_abnormal_hepatobiliary_system0.83086123
78MP0006054_spinal_hemorrhage0.81544091
79MP0001958_emphysema0.80562464
80MP0001986_abnormal_taste_sensitivity0.80333282
81MP0002332_abnormal_exercise_endurance0.80067090
82MP0003453_abnormal_keratinocyte_physiol0.79377397
83MP0005451_abnormal_body_composition0.77686739
84MP0003186_abnormal_redox_activity0.77363447
85MP0003866_abnormal_defecation0.76621444
86MP0000249_abnormal_blood_vessel0.76141143
87MP0003279_aneurysm0.75050764
88MP0002254_reproductive_system_inflammat0.72060404
89MP0003795_abnormal_bone_structure0.72009914
90MP0003763_abnormal_thymus_physiology0.71249367
91MP0003045_fibrosis0.70531786
92MP0005075_abnormal_melanosome_morpholog0.70170968
93MP0003566_abnormal_cell_adhesion0.68593610
94MP0003705_abnormal_hypodermis_morpholog0.67464626
95MP0001663_abnormal_digestive_system0.67432361
96MP0003656_abnormal_erythrocyte_physiolo0.65882695
97MP0002396_abnormal_hematopoietic_system0.65355152
98MP0009765_abnormal_xenobiotic_induced0.64527999
99MP0005319_abnormal_enzyme/_coenzyme0.63773734
100MP0008874_decreased_physiological_sensi0.63506972
101MP0002693_abnormal_pancreas_physiology0.61738078
102MP0005023_abnormal_wound_healing0.60076309
103MP0001873_stomach_inflammation0.59754211
104MP0010307_abnormal_tumor_latency0.57421499
105MP0002877_abnormal_melanocyte_morpholog0.55517675
106MP0000767_abnormal_smooth_muscle0.54732885
107MP0000703_abnormal_thymus_morphology0.53511095
108MP0002653_abnormal_ependyma_morphology0.52834619
109MP0005535_abnormal_body_temperature0.49107119
110MP0004130_abnormal_muscle_cell0.47647374
111MP0002136_abnormal_kidney_physiology0.47635473
112MP0001542_abnormal_bone_strength0.47301969
113MP0000371_diluted_coat_color0.46212073
114MP0002132_abnormal_respiratory_system0.45047774
115MP0000015_abnormal_ear_pigmentation0.44746231
116MP0000490_abnormal_crypts_of0.44562548

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)9.41212909
2Recurrent bacterial skin infections (HP:0005406)8.57233465
3Eczematoid dermatitis (HP:0000976)8.44568200
4Recurrent gram-negative bacterial infections (HP:0005420)7.80925851
5Abnormality of macrophages (HP:0004311)5.76796778
6Mediastinal lymphadenopathy (HP:0100721)5.60302876
7Recurrent skin infections (HP:0001581)5.05751076
8Gingivitis (HP:0000230)4.93401054
9Obstructive lung disease (HP:0006536)4.84736354
10Chronic obstructive pulmonary disease (HP:0006510)4.84736354
11Stomatitis (HP:0010280)4.49326934
12Myositis (HP:0100614)4.46000098
13Recurrent fungal infections (HP:0002841)4.32655526
14Elevated erythrocyte sedimentation rate (HP:0003565)4.25571333
15Systemic lupus erythematosus (HP:0002725)4.02848145
16Cellulitis (HP:0100658)3.96295022
17Orchitis (HP:0100796)3.88530538
18Vacuolated lymphocytes (HP:0001922)3.73680272
19Urticaria (HP:0001025)3.68772280
20Retrobulbar optic neuritis (HP:0100654)3.60843596
21Optic neuritis (HP:0100653)3.60843596
22Interstitial pulmonary disease (HP:0006530)3.48983105
23Increased cerebral lipofuscin (HP:0011813)3.45392534
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.42022669
25Vasculitis (HP:0002633)3.35468237
26Meningitis (HP:0001287)3.24539483
27Episodic fever (HP:0001954)3.22505807
28Increased IgM level (HP:0003496)3.18407421
29Periodontitis (HP:0000704)3.17602838
30Hypochromic microcytic anemia (HP:0004840)3.13639292
31Spontaneous hematomas (HP:0007420)3.09618026
32Pustule (HP:0200039)3.08655280
33Recurrent pneumonia (HP:0006532)3.04905084
34Autoimmune thrombocytopenia (HP:0001973)3.01253224
35Recurrent viral infections (HP:0004429)2.93455338
36Anorexia (HP:0002039)2.93219539
37Hematochezia (HP:0002573)2.91226049
38Chronic mucocutaneous candidiasis (HP:0002728)2.90393187
39Recurrent cutaneous fungal infections (HP:0011370)2.90393187
40T lymphocytopenia (HP:0005403)2.87763714
41Abnormality of liposaccharide metabolism (HP:0010968)2.85750307
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.85750307
43Abnormality of glycolipid metabolism (HP:0010969)2.85750307
44Colitis (HP:0002583)2.82639276
45Petechiae (HP:0000967)2.80834614
46Hypochromic anemia (HP:0001931)2.80636545
47Abnormality of T cell number (HP:0011839)2.80098763
48Glomerulonephritis (HP:0000099)2.74140743
49Gingival bleeding (HP:0000225)2.73396286
50Pulmonary infiltrates (HP:0002113)2.68109692
51Basal ganglia calcification (HP:0002135)2.66892131
52Hypergammaglobulinemia (HP:0010702)2.66594873
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.66362166
54Gangrene (HP:0100758)2.62202788
55Osteomyelitis (HP:0002754)2.61400944
56Recurrent lower respiratory tract infections (HP:0002783)2.56852985
57Inflammation of the large intestine (HP:0002037)2.55909334
58Hepatosplenomegaly (HP:0001433)2.49118007
59Thick nail (HP:0001805)2.47803994
60Abnormality of the pleura (HP:0002103)2.44433662
61Leukocytosis (HP:0001974)2.44411622
62Increased serum ferritin (HP:0003281)2.40193742
63Disinhibition (HP:0000734)2.37681634
64Arterial thrombosis (HP:0004420)2.37022580
65Axonal loss (HP:0003447)2.36479670
66Gastrointestinal inflammation (HP:0004386)2.36051897
67Keratoconjunctivitis sicca (HP:0001097)2.35732494
68Abnormality of T cells (HP:0002843)2.35490592
69Peritonitis (HP:0002586)2.34146920
70Joint hemorrhage (HP:0005261)2.33678354
71Gastrointestinal infarctions (HP:0005244)2.29718732
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28386290
73Abnormality of iron homeostasis (HP:0011031)2.26684837
74Epistaxis (HP:0000421)2.25182680
75Hemoptysis (HP:0002105)2.24094294
76Sepsis (HP:0100806)2.22593388
77Increased IgE level (HP:0003212)2.22524568
78Granulocytopenia (HP:0001913)2.21969085
79Panhypogammaglobulinemia (HP:0003139)2.21076334
80Gastrointestinal stroma tumor (HP:0100723)2.20857542
81Polyneuropathy (HP:0001271)2.19271265
82Vertigo (HP:0002321)2.18763388
83Keratitis (HP:0000491)2.17788172
84IgM deficiency (HP:0002850)2.15721468
85Dysostosis multiplex (HP:0000943)2.14792801
86Chronic otitis media (HP:0000389)2.14031196
87Acne (HP:0001061)2.13863970
88Prostate neoplasm (HP:0100787)2.13503022
89Microcytic anemia (HP:0001935)2.13415198
90Abnormality of the endocardium (HP:0004306)2.12820445
91Keratoconjunctivitis (HP:0001096)2.11793514
92Osteolytic defects of the hand bones (HP:0009699)2.10386995
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.10386995
94Abnormality of the pericardium (HP:0001697)2.08326732
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.07143221
96Myocardial infarction (HP:0001658)2.06822346
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03551737
98Abnormality of polysaccharide metabolism (HP:0011012)2.03551737
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03551737
100Amyloidosis (HP:0011034)2.02874543
101Skin ulcer (HP:0200042)2.02763585
102Purpura (HP:0000979)2.01965537
103Eosinophilia (HP:0001880)2.01639525
104Glomerulopathy (HP:0100820)2.01577324
105Mutism (HP:0002300)1.98557131
106Premature loss of primary teeth (HP:0006323)1.97559922
107Abnormality of the peritoneum (HP:0002585)1.97013221
108Nephritis (HP:0000123)1.94474574
109Abnormality of T cell physiology (HP:0011840)1.93972592
110Abnormality of transition element cation homeostasis (HP:0011030)1.92129157
111Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90582059
112Abnormality of cells of the lymphoid lineage (HP:0012140)1.90230227
113Lymphopenia (HP:0001888)1.90033759
114Pulmonary embolism (HP:0002204)1.89935464
115Prolonged bleeding time (HP:0003010)1.85915685
116Encephalitis (HP:0002383)1.85297269
117IgA deficiency (HP:0002720)1.84425321
118Arthralgia (HP:0002829)1.83074783
119Abnormality of complement system (HP:0005339)1.82394967
120Chest pain (HP:0100749)1.82363430
121Restrictive lung disease (HP:0002091)1.80448927
122Mitral stenosis (HP:0001718)1.80322675
123Vertebral compression fractures (HP:0002953)1.73959625
124Cheilitis (HP:0100825)1.72769464
125Poor head control (HP:0002421)1.72047853
126Thyroiditis (HP:0100646)1.71117755
127Pathologic fracture (HP:0002756)1.67730377
128Progressive visual loss (HP:0000529)1.66700877
129Loss of speech (HP:0002371)1.65518797
130Abnormal platelet volume (HP:0011876)1.64161021
131Agammaglobulinemia (HP:0004432)1.63256252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK45.15467284
2BLK4.89156238
3RIPK44.63716450
4MAP3K143.96559152
5TBK12.92261402
6TYK22.86274725
7MAP4K12.46150415
8EPHB12.35950039
9CSK2.32126131
10ERN12.26322021
11IRAK32.17522780
12MAP3K122.14477785
13BTK2.09945928
14IKBKE2.05738273
15ZAP701.94342728
16IKBKB1.93659453
17PBK1.84502596
18TXK1.80844764
19STK101.75177508
20FGR1.69538532
21HCK1.61609742
22TEC1.55600125
23MARK31.52236759
24KIT1.48154773
25JAK11.47339992
26PRPF4B1.43979949
27JAK31.42675156
28CLK11.37230609
29SYK1.36247975
30FES1.33546707
31MST41.28630508
32TRPM71.24376764
33MAP3K111.22519783
34LYN1.20823947
35RPS6KA41.16406339
36CHUK1.15947148
37JAK21.15029927
38MAP3K131.13774687
39TAOK21.09966844
40MAP2K31.08729373
41LRRK21.06550396
42NEK91.04955864
43CSF1R1.04264668
44GRK61.00141483
45TAOK30.99776579
46PRKG20.91292693
47ERBB30.90645051
48IRAK20.90579057
49LCK0.89511490
50PIM10.89438221
51ITK0.86407018
52TTN0.86243060
53ABL20.85004056
54KSR20.82027531
55DAPK20.81421745
56IRAK10.78925941
57CDC42BPA0.78824136
58PRKD20.78274054
59MARK20.78266008
60TGFBR20.78012455
61NME20.77258225
62RIPK10.76007911
63BMX0.75074735
64MAP2K60.74394971
65MAP3K60.72658511
66BMPR20.72502330
67MATK0.71206731
68YES10.70152523
69MAPKAPK20.65757270
70PTK60.65539137
71GRK70.61866231
72ACVR1B0.61173358
73MAP3K50.60910115
74EGFR0.58581120
75MAP2K40.58566602
76CAMKK20.58047369
77ABL10.57557476
78STK40.57079518
79PRKCD0.56803972
80KDR0.56457069
81PIM20.54248675
82FRK0.54039578
83STK110.52859454
84MAP3K20.52063441
85TRIB30.51783904
86EIF2AK20.51000990
87SIK30.50980588
88MAPK70.50959065
89EPHA30.50275932
90PAK40.49796595
91PRKCQ0.49272469
92FYN0.49155698
93CDK190.48379191
94ALK0.46324750
95HIPK20.44773016
96MAP3K10.44537586
97MAP3K70.43912609
98MAPK120.43892183
99RPS6KC10.42121308
100RPS6KL10.42121308
101DYRK1B0.41896983
102FGFR30.40793605
103KSR10.40367669
104MAP3K30.37597871
105SIK20.35911698
106MAP3K80.35405374
107TESK20.35259164
108NLK0.33447927
109DYRK30.32316375
110MAPK40.32311242
111PRKCZ0.30671236
112RPS6KA10.30474476
113GRK10.30462348
114PTK2B0.30315809
115PDK10.30046894
116STK380.29760466
117PRKAA20.29478483
118RAF10.28556730
119PDPK10.28364085
120SGK20.28344020
121PIK3CG0.24304239
122CDK120.23310188
123RPS6KA60.23105242
124MOS0.20167853
125PTK20.18328630
126ADRBK20.17496047
127TNK20.17090000
128SRC0.15003516
129SGK30.14801683
130TAOK10.14555674

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.88032083
2Staphylococcus aureus infection_Homo sapiens_hsa051503.65151032
3Asthma_Homo sapiens_hsa053103.51575149
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.64231549
5Graft-versus-host disease_Homo sapiens_hsa053322.55095982
6* Osteoclast differentiation_Homo sapiens_hsa043802.54495352
7Allograft rejection_Homo sapiens_hsa053302.45721256
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.44789453
9Tuberculosis_Homo sapiens_hsa051522.39606866
10Pertussis_Homo sapiens_hsa051332.38779058
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.29745979
12Legionellosis_Homo sapiens_hsa051342.28571364
13Malaria_Homo sapiens_hsa051442.23001014
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.04095781
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89868614
16B cell receptor signaling pathway_Homo sapiens_hsa046621.89602227
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88687394
18Measles_Homo sapiens_hsa051621.86769749
19Rheumatoid arthritis_Homo sapiens_hsa053231.83225217
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82751098
21TNF signaling pathway_Homo sapiens_hsa046681.76848626
22Salmonella infection_Homo sapiens_hsa051321.73650824
23Hematopoietic cell lineage_Homo sapiens_hsa046401.72639325
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72512917
25Toxoplasmosis_Homo sapiens_hsa051451.70728243
26Chemokine signaling pathway_Homo sapiens_hsa040621.70268550
27Phagosome_Homo sapiens_hsa041451.65427435
28Type I diabetes mellitus_Homo sapiens_hsa049401.64844144
29Influenza A_Homo sapiens_hsa051641.63388972
30Shigellosis_Homo sapiens_hsa051311.58695539
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.56438115
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48264319
33Lysosome_Homo sapiens_hsa041421.45999053
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45193900
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34757689
36Herpes simplex infection_Homo sapiens_hsa051681.34223974
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33931288
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.32574439
39Viral myocarditis_Homo sapiens_hsa054161.30686919
40African trypanosomiasis_Homo sapiens_hsa051431.28921528
41Autoimmune thyroid disease_Homo sapiens_hsa053201.22930974
42Other glycan degradation_Homo sapiens_hsa005111.21485437
43Apoptosis_Homo sapiens_hsa042101.21272483
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08982424
45Antigen processing and presentation_Homo sapiens_hsa046121.08059808
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04789183
47Primary immunodeficiency_Homo sapiens_hsa053401.03748983
48Hepatitis B_Homo sapiens_hsa051611.03341858
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97929540
50Acute myeloid leukemia_Homo sapiens_hsa052210.94968741
51Complement and coagulation cascades_Homo sapiens_hsa046100.89715372
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87900159
53Amoebiasis_Homo sapiens_hsa051460.87754692
54Hepatitis C_Homo sapiens_hsa051600.87211995
55Platelet activation_Homo sapiens_hsa046110.87034050
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81666978
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79077147
58Caffeine metabolism_Homo sapiens_hsa002320.74640024
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.73178315
60T cell receptor signaling pathway_Homo sapiens_hsa046600.72868787
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.70236538
62Chronic myeloid leukemia_Homo sapiens_hsa052200.66734905
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66000277
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.63950977
65Pancreatic cancer_Homo sapiens_hsa052120.62599752
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59665974
67Prolactin signaling pathway_Homo sapiens_hsa049170.59384246
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56289145
69Epstein-Barr virus infection_Homo sapiens_hsa051690.56206273
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54329147
71VEGF signaling pathway_Homo sapiens_hsa043700.54115894
72Regulation of autophagy_Homo sapiens_hsa041400.51945825
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51511992
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50957393
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47381639
76Notch signaling pathway_Homo sapiens_hsa043300.43258735
77Prion diseases_Homo sapiens_hsa050200.43231419
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.42211321
79Insulin resistance_Homo sapiens_hsa049310.42115993
80GnRH signaling pathway_Homo sapiens_hsa049120.40825147
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36873122
82Endocytosis_Homo sapiens_hsa041440.36810040
83Collecting duct acid secretion_Homo sapiens_hsa049660.35221413
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34052835
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32373960
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.31411317
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30915235
88Choline metabolism in cancer_Homo sapiens_hsa052310.30697205
89Viral carcinogenesis_Homo sapiens_hsa052030.30094203
90Sphingolipid metabolism_Homo sapiens_hsa006000.29105851
91HIF-1 signaling pathway_Homo sapiens_hsa040660.28608682
92Pentose phosphate pathway_Homo sapiens_hsa000300.27977261
93mTOR signaling pathway_Homo sapiens_hsa041500.26376721
94MAPK signaling pathway_Homo sapiens_hsa040100.25706470
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25286975
96Proteoglycans in cancer_Homo sapiens_hsa052050.23725255
97Dorso-ventral axis formation_Homo sapiens_hsa043200.23269238
98Type II diabetes mellitus_Homo sapiens_hsa049300.22845978
99FoxO signaling pathway_Homo sapiens_hsa040680.22814719
100Bladder cancer_Homo sapiens_hsa052190.22613976
101Endometrial cancer_Homo sapiens_hsa052130.22497519
102HTLV-I infection_Homo sapiens_hsa051660.19913755
103Histidine metabolism_Homo sapiens_hsa003400.18949637
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16271860
105Non-small cell lung cancer_Homo sapiens_hsa052230.15438552
106Renal cell carcinoma_Homo sapiens_hsa052110.15105001
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.13851736
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11992513
109MicroRNAs in cancer_Homo sapiens_hsa052060.11730897
110Rap1 signaling pathway_Homo sapiens_hsa040150.10232058
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10012180
112Small cell lung cancer_Homo sapiens_hsa052220.09639321
113Mineral absorption_Homo sapiens_hsa049780.07917813

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