LILRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.27700437
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27700437
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27700437
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.27700437
5modulation by symbiont of host immune response (GO:0052553)5.27700437
6positive regulation by symbiont of host defense response (GO:0052509)5.27700437
7response to peptidoglycan (GO:0032494)5.15095014
8macrophage activation involved in immune response (GO:0002281)4.97198889
9* positive regulation of gamma-delta T cell activation (GO:0046645)4.95173604
10* negative regulation of interleukin-12 production (GO:0032695)4.86422736
11immunoglobulin mediated immune response (GO:0016064)4.70155361
12neutrophil activation involved in immune response (GO:0002283)4.39123485
13* negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.12681179
14* negative regulation of cell killing (GO:0031342)4.12681179
15cellular response to type I interferon (GO:0071357)4.08476458
16type I interferon signaling pathway (GO:0060337)4.08476458
17detection of other organism (GO:0098543)4.06810790
18interferon-gamma-mediated signaling pathway (GO:0060333)4.06310963
19response to type I interferon (GO:0034340)4.06222333
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06089122
21regulation of dendritic cell antigen processing and presentation (GO:0002604)4.02027717
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.98796955
23regulation of interferon-beta biosynthetic process (GO:0045357)3.98482762
24regulation of B cell receptor signaling pathway (GO:0050855)3.96143655
25antigen processing and presentation of endogenous antigen (GO:0019883)3.95468460
26detection of bacterium (GO:0016045)3.92009877
27defense response to protozoan (GO:0042832)3.88497818
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88333639
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.85700954
30regulation of antigen processing and presentation (GO:0002577)3.85401479
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83010797
32T-helper 1 type immune response (GO:0042088)3.75405303
33regulation of T-helper 1 cell differentiation (GO:0045625)3.70943984
34regulation of interferon-alpha production (GO:0032647)3.67154236
35response to protozoan (GO:0001562)3.66421499
36detection of molecule of bacterial origin (GO:0032490)3.65341023
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65292493
38B cell mediated immunity (GO:0019724)3.63506207
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.62636215
40response to host immune response (GO:0052572)3.62636215
41positive regulation of antigen processing and presentation (GO:0002579)3.62075811
42microglial cell activation (GO:0001774)3.61144630
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59325865
44germinal center formation (GO:0002467)3.57385621
45T cell migration (GO:0072678)3.54677965
46positive regulation of type 2 immune response (GO:0002830)3.52539906
47detection of external biotic stimulus (GO:0098581)3.51876068
48response to muramyl dipeptide (GO:0032495)3.49518534
49cellular extravasation (GO:0045123)3.49224993
50regulation of T cell tolerance induction (GO:0002664)3.48493741
51NIK/NF-kappaB signaling (GO:0038061)3.48376971
52positive regulation of interferon-alpha production (GO:0032727)3.48044116
53myeloid cell activation involved in immune response (GO:0002275)3.46772500
54macrophage activation (GO:0042116)3.43488963
55granulocyte activation (GO:0036230)3.37983630
56* regulation of gamma-delta T cell activation (GO:0046643)3.36840098
57leukocyte aggregation (GO:0070486)3.34308933
58neutrophil activation (GO:0042119)3.30329108
59respiratory burst (GO:0045730)3.26944022
60regulation of vitamin D biosynthetic process (GO:0060556)3.26125280
61regulation of tolerance induction (GO:0002643)3.24731985
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.24101689
63response to host (GO:0075136)3.24101689
64response to host defenses (GO:0052200)3.24101689
65myeloid dendritic cell differentiation (GO:0043011)3.18849857
66regulation of mast cell degranulation (GO:0043304)3.18718378
67cellular response to interferon-gamma (GO:0071346)3.17977008
68detection of biotic stimulus (GO:0009595)3.17566123
69positive regulation of mast cell activation (GO:0033005)3.15419953
70B cell receptor signaling pathway (GO:0050853)3.06577349
71regulation of mast cell activation (GO:0033003)3.05499259
72myeloid dendritic cell activation (GO:0001773)3.05111765
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.04570493
74* regulation of interleukin-12 production (GO:0032655)3.03944826
75response to interferon-gamma (GO:0034341)2.99224411
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96342539
77positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.95808166
78* regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95465151
79negative regulation of myeloid cell apoptotic process (GO:0033033)2.94916330
80regulation of mast cell activation involved in immune response (GO:0033006)2.94869188
81positive regulation of B cell differentiation (GO:0045579)2.94297518
82regulation of T-helper 2 cell differentiation (GO:0045628)2.93153032
83positive regulation of interferon-beta production (GO:0032728)2.92979939
84positive regulation of cellular amide metabolic process (GO:0034250)2.91190628
85regulation of alpha-beta T cell proliferation (GO:0046640)2.87746507
86regulation of type 2 immune response (GO:0002828)2.86400410
87positive regulation of chemokine biosynthetic process (GO:0045080)2.85645540
88positive regulation of immunoglobulin mediated immune response (GO:0002891)2.84254608
89positive regulation of B cell mediated immunity (GO:0002714)2.84254608
90regulation of podosome assembly (GO:0071801)2.84119275
91positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83996973
92positive regulation of tolerance induction (GO:0002645)2.83096374
93regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.82817644
94regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80407385
95regulation of interleukin-2 biosynthetic process (GO:0045076)2.80246026
96positive regulation of interleukin-1 beta secretion (GO:0050718)2.79904719
97myeloid leukocyte activation (GO:0002274)2.79695077
98regulation of interleukin-8 biosynthetic process (GO:0045414)2.78717578
99* negative regulation of cytokine production involved in immune response (GO:0002719)2.78619959
100regulation of gamma-delta T cell differentiation (GO:0045586)2.77724357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.13201566
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.23471188
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.59017101
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.03165775
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.85457746
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.78105154
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.63713869
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.59716212
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40654172
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25637216
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05429329
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.91982457
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72337755
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.72294820
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70697159
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65920494
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62700907
18SPI1_23547873_ChIP-Seq_NB4_Human2.45327330
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41663498
20VDR_24763502_ChIP-Seq_THP-1_Human2.41208340
21RUNX_20019798_ChIP-Seq_JUKART_Human2.40588660
22VDR_21846776_ChIP-Seq_THP-1_Human2.33972048
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.32840338
24SPI1_23127762_ChIP-Seq_K562_Human2.30374782
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24059214
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.19069466
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.18487229
28VDR_24787735_ChIP-Seq_THP-1_Human2.13383238
29MYB_26560356_Chip-Seq_TH2_Human2.11582422
30MAF_26560356_Chip-Seq_TH1_Human2.04261406
31SCL_19346495_ChIP-Seq_HPC-7_Human2.03765180
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97824714
33MYC_22102868_ChIP-Seq_BL_Human1.86886877
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83272326
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.83017956
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75843834
37MYB_26560356_Chip-Seq_TH1_Human1.73612454
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69911050
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.68245432
40UTX_26944678_Chip-Seq_JUKART_Human1.63401175
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63003550
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60899732
43GATA1_22025678_ChIP-Seq_K562_Human1.55899445
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55477973
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53131606
46GATA3_27048872_Chip-Seq_THYMUS_Human1.48675413
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47920792
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47105341
49PU_27001747_Chip-Seq_BMDM_Mouse1.43781753
50MAF_26560356_Chip-Seq_TH2_Human1.43597616
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36874959
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36264934
53TCF7_22412390_ChIP-Seq_EML_Mouse1.35391934
54* GATA3_26560356_Chip-Seq_TH2_Human1.34204879
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34137346
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32661851
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32071872
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.31811773
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30850225
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26891172
61KDM2B_26808549_Chip-Seq_DND41_Human1.24802461
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24764545
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24531940
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24326223
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23934609
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22997811
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20586095
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19071768
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16959147
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15839720
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14046576
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11155517
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10683479
74LXR_22292898_ChIP-Seq_THP-1_Human1.04788986
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04670663
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04328165
77BCL6_27268052_Chip-Seq_Bcells_Human1.03420150
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03100869
79GATA1_19941826_ChIP-Seq_K562_Human1.02747670
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.01393800
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99186792
82STAT1_20625510_ChIP-Seq_HELA_Human0.99083707
83STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97149055
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96903746
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.96719840
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93798293
87BCOR_27268052_Chip-Seq_Bcells_Human0.91719158
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90919210
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90569170
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90042878
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.87934615
92SMRT_27268052_Chip-Seq_Bcells_Human0.84331993
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77813061
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.74047480
95GATA2_19941826_ChIP-Seq_K562_Human0.71947256
96TFEB_21752829_ChIP-Seq_HELA_Human0.70792655
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.70208955
98SPI1_20517297_ChIP-Seq_HL60_Human0.67049650
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64907137
100NCOR1_26117541_ChIP-Seq_K562_Human0.63404220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.68186466
2MP0001835_abnormal_antigen_presentation4.06147603
3MP0003724_increased_susceptibility_to3.85840300
4MP0003436_decreased_susceptibility_to3.77675542
5MP0005671_abnormal_response_to3.51647757
6MP0009785_altered_susceptibility_to3.40614503
7MP0005387_immune_system_phenotype3.32949271
8MP0001790_abnormal_immune_system3.32949271
9MP0006082_CNS_inflammation3.18965914
10MP0002148_abnormal_hypersensitivity_rea3.17317510
11MP0005000_abnormal_immune_tolerance3.14399024
12MP0000685_abnormal_immune_system3.05935873
13MP0002419_abnormal_innate_immunity2.96286602
14MP0001800_abnormal_humoral_immune2.95958957
15MP0005025_abnormal_response_to2.86228667
16MP0002452_abnormal_antigen_presenting2.67724981
17MP0002723_abnormal_immune_serum2.66427884
18MP0003300_gastrointestinal_ulcer2.43302150
19MP0002420_abnormal_adaptive_immunity2.35337111
20MP0001819_abnormal_immune_cell2.34170121
21MP0005058_abnormal_lysosome_morphology2.17474858
22MP0004510_myositis2.13964487
23MP0001533_abnormal_skeleton_physiology2.04876750
24MP0009764_decreased_sensitivity_to2.03381862
25MP0003172_abnormal_lysosome_physiology1.99772763
26MP0001845_abnormal_inflammatory_respons1.92793969
27MP0002405_respiratory_system_inflammati1.88257099
28MP0010155_abnormal_intestine_physiology1.85843785
29MP0009278_abnormal_bone_marrow1.79039401
30MP0004947_skin_inflammation1.78290852
31MP0000716_abnormal_immune_system1.74419696
32MP0005310_abnormal_salivary_gland1.71930532
33MP0005464_abnormal_platelet_physiology1.71204967
34MP0003075_altered_response_to1.70267705
35MP0008469_abnormal_protein_level1.64397587
36MP0009333_abnormal_splenocyte_physiolog1.63022415
37MP0002398_abnormal_bone_marrow1.61675625
38MP0000343_altered_response_to1.57386698
39MP0003763_abnormal_thymus_physiology1.54483027
40MP0009840_abnormal_foam_cell1.53768182
41MP0001853_heart_inflammation1.45618761
42MP0005451_abnormal_body_composition1.45160533
43MP0002998_abnormal_bone_remodeling1.43578971
44MP0005397_hematopoietic_system_phenotyp1.40765790
45MP0001545_abnormal_hematopoietic_system1.40765790
46MP0000689_abnormal_spleen_morphology1.40132081
47MP0005167_abnormal_blood-brain_barrier1.39976559
48MP0003191_abnormal_cellular_cholesterol1.39887752
49MP0002429_abnormal_blood_cell1.34558439
50MP0002138_abnormal_hepatobiliary_system1.34467258
51MP0000604_amyloidosis1.33567402
52MP0003690_abnormal_glial_cell1.27995019
53MP0002139_abnormal_hepatobiliary_system1.27533255
54MP0002722_abnormal_immune_system1.27255347
55MP0000858_altered_metastatic_potential1.23112731
56MP0003806_abnormal_nucleotide_metabolis1.20505599
57MP0005166_decreased_susceptibility_to1.20015781
58MP0008004_abnormal_stomach_pH1.17811586
59MP0003183_abnormal_peptide_metabolism1.16152377
60MP0008260_abnormal_autophagy1.15787412
61MP0003448_altered_tumor_morphology1.15089089
62MP0002254_reproductive_system_inflammat1.14138792
63MP0003828_pulmonary_edema1.07360817
64MP0003656_abnormal_erythrocyte_physiolo1.00173061
65MP0004883_abnormal_blood_vessel0.97558754
66MP0009763_increased_sensitivity_to0.95628645
67MP0001873_stomach_inflammation0.95066074
68MP0001663_abnormal_digestive_system0.94180406
69MP0002332_abnormal_exercise_endurance0.92795536
70MP0005164_abnormal_response_to0.90347837
71MP0000703_abnormal_thymus_morphology0.86728390
72MP0003866_abnormal_defecation0.86099139
73MP0000465_gastrointestinal_hemorrhage0.84536262
74MP0002277_abnormal_respiratory_mucosa0.84028355
75MP0003195_calcinosis0.83884458
76MP0009765_abnormal_xenobiotic_induced0.79742295
77MP0003453_abnormal_keratinocyte_physiol0.78541800
78MP0005390_skeleton_phenotype0.78525852
79MP0002933_joint_inflammation0.73848184
80MP0002166_altered_tumor_susceptibility0.73279241
81MP0001851_eye_inflammation0.71397126
82MP0006054_spinal_hemorrhage0.70728775
83MP0002006_tumorigenesis0.70415213
84MP0008874_decreased_physiological_sensi0.69464793
85MP0000920_abnormal_myelination0.66766402
86MP0003091_abnormal_cell_migration0.66551475
87MP0000249_abnormal_blood_vessel0.64866185
88MP0003045_fibrosis0.64781522
89MP0003795_abnormal_bone_structure0.64136601
90MP0002693_abnormal_pancreas_physiology0.63945413
91MP0002132_abnormal_respiratory_system0.62434819
92MP0004808_abnormal_hematopoietic_stem0.62364546
93MP0000371_diluted_coat_color0.61969131
94MP0003646_muscle_fatigue0.58999246
95MP0005535_abnormal_body_temperature0.50581669
96MP0005381_digestive/alimentary_phenotyp0.50468198
97MP0000015_abnormal_ear_pigmentation0.49892135
98MP0000609_abnormal_liver_physiology0.48494661
99MP0000490_abnormal_crypts_of0.48030584
100MP0001501_abnormal_sleep_pattern0.47944152

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.76615889
2Eczematoid dermatitis (HP:0000976)5.54402589
3Abnormality of macrophages (HP:0004311)5.49615859
4Recurrent abscess formation (HP:0002722)5.42997546
5Retrobulbar optic neuritis (HP:0100654)5.19381379
6Optic neuritis (HP:0100653)5.19381379
7Orchitis (HP:0100796)5.10347315
8Myositis (HP:0100614)5.02759513
9Abnormality of liposaccharide metabolism (HP:0010968)4.67806939
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.67806939
11Abnormality of glycolipid metabolism (HP:0010969)4.67806939
12Stomatitis (HP:0010280)4.53875588
13Mediastinal lymphadenopathy (HP:0100721)4.46269620
14Recurrent gram-negative bacterial infections (HP:0005420)4.31081644
15Recurrent fungal infections (HP:0002841)3.93470401
16Vasculitis (HP:0002633)3.81076097
17Elevated erythrocyte sedimentation rate (HP:0003565)3.80541366
18Meningitis (HP:0001287)3.78119633
19Recurrent skin infections (HP:0001581)3.77160365
20Increased cerebral lipofuscin (HP:0011813)3.65288969
21Keratoconjunctivitis sicca (HP:0001097)3.53918691
22Recurrent viral infections (HP:0004429)3.44294477
23Pulmonary infiltrates (HP:0002113)3.43553401
24Obstructive lung disease (HP:0006536)3.43545149
25Chronic obstructive pulmonary disease (HP:0006510)3.43545149
26Recurrent cutaneous fungal infections (HP:0011370)3.40542348
27Chronic mucocutaneous candidiasis (HP:0002728)3.40542348
28Systemic lupus erythematosus (HP:0002725)3.38677879
29Encephalitis (HP:0002383)3.35231708
30Keratoconjunctivitis (HP:0001096)3.33012666
31Gastrointestinal infarctions (HP:0005244)3.26835544
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.25674599
33Hemoptysis (HP:0002105)3.25374512
34Vacuolated lymphocytes (HP:0001922)3.19694116
35Loss of speech (HP:0002371)3.13784786
36Autoimmune thrombocytopenia (HP:0001973)3.05416232
37Dysostosis multiplex (HP:0000943)3.01562614
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.00076671
39Gastrointestinal stroma tumor (HP:0100723)2.97200753
40Increased IgE level (HP:0003212)2.96414118
41Increased IgM level (HP:0003496)2.95572725
42Spontaneous hematomas (HP:0007420)2.94885735
43Urticaria (HP:0001025)2.89883353
44T lymphocytopenia (HP:0005403)2.84248700
45Disinhibition (HP:0000734)2.83909535
46Gingivitis (HP:0000230)2.82659453
47Abnormality of T cell number (HP:0011839)2.75639355
48Hematochezia (HP:0002573)2.67012256
49Leukocytosis (HP:0001974)2.66791536
50Colitis (HP:0002583)2.65430320
51Gangrene (HP:0100758)2.64827054
52Mutism (HP:0002300)2.64700859
53Increased serum ferritin (HP:0003281)2.64026991
54Arterial thrombosis (HP:0004420)2.63694431
55Cellulitis (HP:0100658)2.60374764
56Panhypogammaglobulinemia (HP:0003139)2.60297705
57Lymphopenia (HP:0001888)2.57730059
58Agammaglobulinemia (HP:0004432)2.50677146
59Inflammation of the large intestine (HP:0002037)2.48585309
60Chest pain (HP:0100749)2.47468900
61Amyloidosis (HP:0011034)2.47296022
62Anorexia (HP:0002039)2.44851592
63Pulmonary embolism (HP:0002204)2.44696475
64Abnormality of the pleura (HP:0002103)2.43147934
65Petechiae (HP:0000967)2.40724673
66Purpura (HP:0000979)2.38877803
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.38620916
68Hypergammaglobulinemia (HP:0010702)2.36559584
69Gastrointestinal inflammation (HP:0004386)2.34509125
70Glomerulonephritis (HP:0000099)2.33886916
71Polyneuropathy (HP:0001271)2.33837033
72Chronic otitis media (HP:0000389)2.33077065
73Restrictive lung disease (HP:0002091)2.32859468
74Abnormality of T cells (HP:0002843)2.30686270
75Recurrent bronchitis (HP:0002837)2.26811853
76Recurrent sinusitis (HP:0011108)2.26515765
77Osteomyelitis (HP:0002754)2.26341422
78Abnormality of iron homeostasis (HP:0011031)2.26071257
79Recurrent pneumonia (HP:0006532)2.24632251
80Pustule (HP:0200039)2.22615403
81Episodic fever (HP:0001954)2.22296914
82Abnormality of polysaccharide metabolism (HP:0011012)2.22271181
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22271181
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22271181
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17898212
86Prolonged bleeding time (HP:0003010)2.12882221
87Epistaxis (HP:0000421)2.11586951
88Autoimmune hemolytic anemia (HP:0001890)2.10904976
89Premature loss of primary teeth (HP:0006323)2.10546517
90Arthralgia (HP:0002829)2.09147421
91Gingival bleeding (HP:0000225)2.07919191
92Granulocytopenia (HP:0001913)2.07649096
93Vertigo (HP:0002321)2.07077128
94Malnutrition (HP:0004395)2.07050896
95Sepsis (HP:0100806)2.05060871
96IgA deficiency (HP:0002720)2.04649187
97Mucopolysacchariduria (HP:0008155)2.02728463
98Urinary glycosaminoglycan excretion (HP:0003541)2.02728463
99Abnormality of the endocardium (HP:0004306)2.02630215
100Joint swelling (HP:0001386)2.00470690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.55962805
2MAP4K13.67756247
3BLK3.52277288
4TYK23.14478094
5MAP3K143.06624491
6IRAK42.85689593
7IRAK32.73967100
8CSK2.57053584
9PRPF4B2.41513853
10MATK2.33165538
11TBK12.30422671
12IKBKE2.28215343
13FGR2.23770793
14JAK32.09117662
15ERN12.09050720
16TXK2.00678895
17MAP3K131.97924273
18GRK71.97272507
19IKBKB1.92649077
20SYK1.85735628
21JAK11.74970195
22MAP2K31.69655409
23CSF1R1.68681082
24BMPR21.64583016
25FES1.58647439
26MAP3K111.55893623
27LYN1.51875315
28BTK1.51260837
29ZAP701.46119406
30KIT1.45412548
31TAOK21.43661824
32TNK21.41298862
33NME21.40779664
34CDC42BPA1.38527185
35DDR21.38326690
36TAOK11.35630101
37TAOK31.34834956
38SIK31.28597487
39MAP3K31.28374515
40HCK1.27959909
41JAK21.21091119
42TGFBR21.20794524
43SIK21.16466859
44MARK31.13255036
45IRAK11.12984570
46LCK1.11844315
47CHUK0.99204282
48ADRBK20.98505789
49MAP3K10.95773890
50ITK0.88590037
51ACVR1B0.88205211
52IRAK20.86961173
53MOS0.84926525
54TEC0.84159579
55GRK60.77304379
56STK100.76815508
57EPHB10.73408263
58PDK10.73034328
59MAPK70.66182994
60PRKCQ0.59860897
61MAP3K50.59738562
62CAMKK20.59267060
63PIM10.59108289
64EPHA30.58068669
65FGFR40.57608255
66DAPK20.56390232
67PDPK10.54859567
68HIPK20.51754462
69FGFR30.51558274
70TYRO30.51296749
71NEK90.51070890
72YES10.48168098
73FYN0.44824547
74PRKD20.44721152
75MAPK120.43296437
76MARK20.43001105
77ABL10.40423594
78RPS6KL10.39139136
79RPS6KC10.39139136
80KSR20.39112440
81PIM20.37350226
82MAP2K60.36181687
83RPS6KA60.35627064
84TESK20.33351749
85MAPK40.32471956
86CDK40.27708806
87PRKCD0.27328556
88INSR0.26831181
89RIPK10.26490340
90MAPKAPK20.26256441
91CAMKK10.25212848
92MAPK110.24655175
93SGK30.23329638
94SIK10.21935602
95EGFR0.21876227
96CAMK1D0.21555813
97ARAF0.20382201
98CDK60.20074320
99STK110.19669387
100STK240.19338304

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.32687625
2Graft-versus-host disease_Homo sapiens_hsa053323.12205836
3Staphylococcus aureus infection_Homo sapiens_hsa051503.01418755
4Leishmaniasis_Homo sapiens_hsa051403.00326229
5Autoimmune thyroid disease_Homo sapiens_hsa053202.92090516
6Asthma_Homo sapiens_hsa053102.84522895
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.83645288
8* Osteoclast differentiation_Homo sapiens_hsa043802.74175148
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52919480
10Type I diabetes mellitus_Homo sapiens_hsa049402.51818543
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50973762
12Rheumatoid arthritis_Homo sapiens_hsa053232.26807578
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.26676546
14Tuberculosis_Homo sapiens_hsa051522.18914575
15Primary immunodeficiency_Homo sapiens_hsa053402.15962188
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10139919
17B cell receptor signaling pathway_Homo sapiens_hsa046622.02745476
18Antigen processing and presentation_Homo sapiens_hsa046121.98299928
19Other glycan degradation_Homo sapiens_hsa005111.90518384
20Malaria_Homo sapiens_hsa051441.87189060
21Influenza A_Homo sapiens_hsa051641.79694089
22Legionellosis_Homo sapiens_hsa051341.76758858
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74894208
24TNF signaling pathway_Homo sapiens_hsa046681.73212882
25Viral myocarditis_Homo sapiens_hsa054161.71520154
26Hematopoietic cell lineage_Homo sapiens_hsa046401.69108162
27Toxoplasmosis_Homo sapiens_hsa051451.66762789
28Measles_Homo sapiens_hsa051621.62539897
29Pertussis_Homo sapiens_hsa051331.59932382
30Herpes simplex infection_Homo sapiens_hsa051681.53619445
31Lysosome_Homo sapiens_hsa041421.52275316
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46767770
33African trypanosomiasis_Homo sapiens_hsa051431.44118410
34Chemokine signaling pathway_Homo sapiens_hsa040621.42701879
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39294390
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38099805
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37271274
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36564219
39Phagosome_Homo sapiens_hsa041451.35970650
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24260513
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.22169741
42T cell receptor signaling pathway_Homo sapiens_hsa046601.20271053
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15512552
44Salmonella infection_Homo sapiens_hsa051321.14623641
45Hepatitis C_Homo sapiens_hsa051601.08133816
46Hepatitis B_Homo sapiens_hsa051611.06778691
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02309103
48Acute myeloid leukemia_Homo sapiens_hsa052210.98309365
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89911615
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.88883838
51Shigellosis_Homo sapiens_hsa051310.86063942
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83213399
53Epstein-Barr virus infection_Homo sapiens_hsa051690.83038679
54Apoptosis_Homo sapiens_hsa042100.82477940
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75436191
56Prolactin signaling pathway_Homo sapiens_hsa049170.66516614
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66462511
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.63341884
59Platelet activation_Homo sapiens_hsa046110.61684391
60VEGF signaling pathway_Homo sapiens_hsa043700.54542150
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.53017529
62Prion diseases_Homo sapiens_hsa050200.52859754
63Amoebiasis_Homo sapiens_hsa051460.51620818
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.49097826
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.48259482
66HTLV-I infection_Homo sapiens_hsa051660.47644220
67Type II diabetes mellitus_Homo sapiens_hsa049300.47166305
68Collecting duct acid secretion_Homo sapiens_hsa049660.46587874
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46189064
70Bladder cancer_Homo sapiens_hsa052190.45663540
71Systemic lupus erythematosus_Homo sapiens_hsa053220.44683593
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43662976
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42254591
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39711850
75Viral carcinogenesis_Homo sapiens_hsa052030.39374282
76HIF-1 signaling pathway_Homo sapiens_hsa040660.37643443
77Pancreatic cancer_Homo sapiens_hsa052120.37319372
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35295610
79Dorso-ventral axis formation_Homo sapiens_hsa043200.34757448
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.32234290
81Non-small cell lung cancer_Homo sapiens_hsa052230.32200834
82Complement and coagulation cascades_Homo sapiens_hsa046100.30582578
83Chronic myeloid leukemia_Homo sapiens_hsa052200.30171758
84GnRH signaling pathway_Homo sapiens_hsa049120.29697469
85Endocytosis_Homo sapiens_hsa041440.28356678
86Renal cell carcinoma_Homo sapiens_hsa052110.28142354
87MAPK signaling pathway_Homo sapiens_hsa040100.28108352
88Notch signaling pathway_Homo sapiens_hsa043300.26115325
89FoxO signaling pathway_Homo sapiens_hsa040680.25821110
90Insulin resistance_Homo sapiens_hsa049310.25071914
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22560299
92Mineral absorption_Homo sapiens_hsa049780.21760518
93Sphingolipid metabolism_Homo sapiens_hsa006000.20333673
94mTOR signaling pathway_Homo sapiens_hsa041500.13121312
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10583997
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09282349
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09191043
98Choline metabolism in cancer_Homo sapiens_hsa052310.08803656
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05691624
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05030136

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