LILRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.54027910
2positive regulation of gamma-delta T cell activation (GO:0046645)5.53048492
3response to peptidoglycan (GO:0032494)5.50027143
4negative regulation of cell killing (GO:0031342)5.44596747
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44596747
6positive regulation by symbiont of host defense response (GO:0052509)5.22516212
7modulation by symbiont of host defense response (GO:0052031)5.22516212
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.22516212
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.22516212
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.22516212
11modulation by symbiont of host immune response (GO:0052553)5.22516212
12neutrophil activation involved in immune response (GO:0002283)5.15436571
13macrophage activation involved in immune response (GO:0002281)5.02622562
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.59184161
15detection of other organism (GO:0098543)4.47865272
16immunoglobulin mediated immune response (GO:0016064)4.28013678
17detection of bacterium (GO:0016045)4.21876581
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08172465
19antigen processing and presentation of endogenous antigen (GO:0019883)4.08072327
20detection of molecule of bacterial origin (GO:0032490)4.06147281
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.99064955
22regulation of interferon-beta biosynthetic process (GO:0045357)3.95882426
23regulation of gamma-delta T cell activation (GO:0046643)3.91333430
24lipopolysaccharide-mediated signaling pathway (GO:0031663)3.90634040
25detection of external biotic stimulus (GO:0098581)3.87944292
26cellular response to type I interferon (GO:0071357)3.85879786
27type I interferon signaling pathway (GO:0060337)3.85879786
28response to type I interferon (GO:0034340)3.81674014
29leukocyte aggregation (GO:0070486)3.77690614
30granulocyte activation (GO:0036230)3.76812316
31neutrophil activation (GO:0042119)3.76290153
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73277015
33cellular extravasation (GO:0045123)3.69117108
34regulation of dendritic cell antigen processing and presentation (GO:0002604)3.64138418
35microglial cell activation (GO:0001774)3.62801391
36macrophage activation (GO:0042116)3.62235853
37interferon-gamma-mediated signaling pathway (GO:0060333)3.59729466
38defense response to protozoan (GO:0042832)3.57918358
39myeloid cell activation involved in immune response (GO:0002275)3.57885058
40response to host immune response (GO:0052572)3.56206647
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.56206647
42negative regulation of cytokine production involved in immune response (GO:0002719)3.54914564
43negative regulation of T cell mediated immunity (GO:0002710)3.54380533
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51535124
45detection of biotic stimulus (GO:0009595)3.50031977
46response to muramyl dipeptide (GO:0032495)3.49795871
47regulation of interferon-alpha production (GO:0032647)3.49700138
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.49038232
49regulation of mast cell degranulation (GO:0043304)3.45894474
50regulation of B cell receptor signaling pathway (GO:0050855)3.45587569
51germinal center formation (GO:0002467)3.45424247
52respiratory burst (GO:0045730)3.43232202
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.40655251
54positive regulation of type 2 immune response (GO:0002830)3.40200317
55regulation of T-helper 1 cell differentiation (GO:0045625)3.37351547
56T-helper 1 type immune response (GO:0042088)3.36764384
57response to protozoan (GO:0001562)3.32918009
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28771474
59positive regulation of interferon-alpha production (GO:0032727)3.28027526
60B cell mediated immunity (GO:0019724)3.27986940
61regulation of T-helper 2 cell differentiation (GO:0045628)3.27750097
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22647419
63response to host (GO:0075136)3.22647419
64response to host defenses (GO:0052200)3.22647419
65positive regulation of antigen processing and presentation (GO:0002579)3.22234115
66positive regulation of mast cell activation (GO:0033005)3.20508230
67regulation of mast cell activation involved in immune response (GO:0033006)3.18237574
68production of molecular mediator involved in inflammatory response (GO:0002532)3.16590071
69negative regulation of leukocyte mediated immunity (GO:0002704)3.12649106
70negative regulation of erythrocyte differentiation (GO:0045647)3.12046735
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07391422
72regulation of mast cell activation (GO:0033003)3.06267863
73regulation of interleukin-12 production (GO:0032655)3.04456216
74NIK/NF-kappaB signaling (GO:0038061)3.03913357
75regulation of leukocyte degranulation (GO:0043300)3.03181713
76T cell migration (GO:0072678)3.02961645
77neutrophil mediated immunity (GO:0002446)3.02416481
78positive regulation of cellular amide metabolic process (GO:0034250)2.99452607
79regulation of type 2 immune response (GO:0002828)2.99064832
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98967774
81positive regulation of mast cell degranulation (GO:0043306)2.94964145
82positive regulation of mast cell activation involved in immune response (GO:0033008)2.94964145
83regulation of vitamin D biosynthetic process (GO:0060556)2.93086402
84interferon-gamma secretion (GO:0072643)2.91211977
85myeloid dendritic cell differentiation (GO:0043011)2.89758407
86regulation of interleukin-8 biosynthetic process (GO:0045414)2.86813108
87positive regulation of interleukin-1 beta secretion (GO:0050718)2.86775847
88negative regulation of innate immune response (GO:0045824)2.86551216
89negative regulation of production of molecular mediator of immune response (GO:0002701)2.86321768
90regulation of podosome assembly (GO:0071801)2.84657870
91regulation of cytokine secretion involved in immune response (GO:0002739)2.83491721
92myeloid leukocyte activation (GO:0002274)2.83435810
93positive regulation of interferon-beta production (GO:0032728)2.82586569
94myeloid dendritic cell activation (GO:0001773)2.81818538
95positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81767616
96leukocyte migration involved in inflammatory response (GO:0002523)2.79654443
97cellular response to interferon-gamma (GO:0071346)2.77890183
98negative regulation of interleukin-6 production (GO:0032715)2.75490052
99regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.73896282
100positive regulation of NF-kappaB import into nucleus (GO:0042346)2.73823573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.06754522
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.06289476
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.96583592
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.68815118
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.54981232
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44139527
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44008031
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43748253
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16297938
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14937293
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08447738
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87109304
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.84561299
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76434252
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65135957
16VDR_24763502_ChIP-Seq_THP-1_Human2.52405987
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.51159830
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.49349244
19SPI1_23547873_ChIP-Seq_NB4_Human2.48077444
20VDR_21846776_ChIP-Seq_THP-1_Human2.47200109
21SPI1_23127762_ChIP-Seq_K562_Human2.44817593
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41890955
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40540412
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31493538
25RUNX_20019798_ChIP-Seq_JUKART_Human2.24768317
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15534503
27SCL_19346495_ChIP-Seq_HPC-7_Human2.05356723
28MAF_26560356_Chip-Seq_TH1_Human2.04280882
29VDR_24787735_ChIP-Seq_THP-1_Human2.02448716
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00563855
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.99191941
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96975855
33MYB_26560356_Chip-Seq_TH2_Human1.93888610
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92370993
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82917606
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.80869028
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76901610
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76475461
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70743081
40UTX_26944678_Chip-Seq_JUKART_Human1.70609287
41MYC_22102868_ChIP-Seq_BL_Human1.64494254
42TCF7_22412390_ChIP-Seq_EML_Mouse1.62891060
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61507335
44MYB_26560356_Chip-Seq_TH1_Human1.60874027
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58448645
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55718285
47KDM2B_26808549_Chip-Seq_DND41_Human1.50786045
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50036731
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44457595
50MAF_26560356_Chip-Seq_TH2_Human1.44316501
51PU_27001747_Chip-Seq_BMDM_Mouse1.44190951
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.42225797
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42011255
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40091365
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38074447
56GATA1_22025678_ChIP-Seq_K562_Human1.36681900
57GATA3_27048872_Chip-Seq_THYMUS_Human1.34714625
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33328280
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32722502
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32671726
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.32513717
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32350555
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32032663
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31440393
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31423353
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30715375
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29543235
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26771249
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23126585
70LXR_22292898_ChIP-Seq_THP-1_Human1.22549927
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22060034
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20607152
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18059913
74GATA3_26560356_Chip-Seq_TH2_Human1.15351621
75GATA1_19941826_ChIP-Seq_K562_Human1.14647489
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11167721
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10416132
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08684385
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05591616
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.03584546
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02515258
82* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00861342
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00381983
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99986115
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98526134
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95887244
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.94656368
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92995790
89* BCL6_27268052_Chip-Seq_Bcells_Human0.92576708
90* BCOR_27268052_Chip-Seq_Bcells_Human0.88091818
91GATA2_19941826_ChIP-Seq_K562_Human0.81576555
92NCOR1_26117541_ChIP-Seq_K562_Human0.78541486
93* STAT1_20625510_ChIP-Seq_HELA_Human0.76047839
94TFEB_21752829_ChIP-Seq_HELA_Human0.74207536
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73484089
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73107007
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.72132178
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.71240117
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71134855
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70899191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.97090307
2MP0003724_increased_susceptibility_to4.55428179
3MP0003436_decreased_susceptibility_to4.02536597
4MP0001835_abnormal_antigen_presentation3.73819424
5MP0006082_CNS_inflammation3.39022395
6MP0009785_altered_susceptibility_to3.32837147
7MP0002148_abnormal_hypersensitivity_rea3.06098597
8MP0002419_abnormal_innate_immunity3.06044911
9MP0005000_abnormal_immune_tolerance2.93617429
10MP0005671_abnormal_response_to2.93126779
11MP0005387_immune_system_phenotype2.88594455
12MP0001790_abnormal_immune_system2.88594455
13MP0005025_abnormal_response_to2.87700809
14MP0001800_abnormal_humoral_immune2.62972204
15MP0003300_gastrointestinal_ulcer2.62302595
16MP0002723_abnormal_immune_serum2.49061250
17MP0000685_abnormal_immune_system2.46835591
18MP0002452_abnormal_antigen_presenting2.46591135
19MP0005058_abnormal_lysosome_morphology2.36429896
20MP0004510_myositis2.35634739
21MP0001533_abnormal_skeleton_physiology2.24437161
22MP0002420_abnormal_adaptive_immunity2.23876603
23MP0001819_abnormal_immune_cell2.23295372
24MP0009764_decreased_sensitivity_to2.04566954
25MP0003172_abnormal_lysosome_physiology2.02294579
26MP0009278_abnormal_bone_marrow1.98312909
27MP0004947_skin_inflammation1.88110042
28MP0002405_respiratory_system_inflammati1.87863870
29MP0003075_altered_response_to1.87318591
30MP0001845_abnormal_inflammatory_respons1.86264408
31MP0010155_abnormal_intestine_physiology1.85263495
32MP0003191_abnormal_cellular_cholesterol1.78615848
33MP0005451_abnormal_body_composition1.75984616
34MP0005464_abnormal_platelet_physiology1.75684768
35MP0008469_abnormal_protein_level1.64769579
36MP0000716_abnormal_immune_system1.62659317
37MP0000343_altered_response_to1.57946878
38MP0008260_abnormal_autophagy1.54176201
39MP0002398_abnormal_bone_marrow1.51458989
40MP0009333_abnormal_splenocyte_physiolog1.50649160
41MP0008004_abnormal_stomach_pH1.49958268
42MP0005397_hematopoietic_system_phenotyp1.49284412
43MP0001545_abnormal_hematopoietic_system1.49284412
44MP0005310_abnormal_salivary_gland1.46854997
45MP0002998_abnormal_bone_remodeling1.45076906
46MP0003690_abnormal_glial_cell1.44271912
47MP0001853_heart_inflammation1.41778585
48MP0003763_abnormal_thymus_physiology1.41047616
49MP0003828_pulmonary_edema1.39833187
50MP0000858_altered_metastatic_potential1.39350342
51MP0009840_abnormal_foam_cell1.34260929
52MP0003448_altered_tumor_morphology1.31149636
53MP0005166_decreased_susceptibility_to1.28735781
54MP0000689_abnormal_spleen_morphology1.28309353
55MP0002429_abnormal_blood_cell1.25363558
56MP0003806_abnormal_nucleotide_metabolis1.25248993
57MP0000604_amyloidosis1.24201139
58MP0002722_abnormal_immune_system1.23824638
59MP0005167_abnormal_blood-brain_barrier1.15650576
60MP0004883_abnormal_blood_vessel1.14329547
61MP0003183_abnormal_peptide_metabolism1.11739408
62MP0005164_abnormal_response_to1.10672312
63MP0000465_gastrointestinal_hemorrhage1.09130414
64MP0002332_abnormal_exercise_endurance1.08844406
65MP0002132_abnormal_respiratory_system1.01908810
66MP0003656_abnormal_erythrocyte_physiolo1.01384456
67MP0002277_abnormal_respiratory_mucosa1.01144424
68MP0006054_spinal_hemorrhage1.00660724
69MP0001851_eye_inflammation0.98699218
70MP0009763_increased_sensitivity_to0.96783725
71MP0003453_abnormal_keratinocyte_physiol0.96418413
72MP0002254_reproductive_system_inflammat0.95349186
73MP0003866_abnormal_defecation0.94796015
74MP0005390_skeleton_phenotype0.91615587
75MP0001663_abnormal_digestive_system0.90347290
76MP0000703_abnormal_thymus_morphology0.86545153
77MP0002139_abnormal_hepatobiliary_system0.81570668
78MP0009765_abnormal_xenobiotic_induced0.80762926
79MP0002138_abnormal_hepatobiliary_system0.78036545
80MP0004808_abnormal_hematopoietic_stem0.72180106
81MP0003091_abnormal_cell_migration0.71249990
82MP0002933_joint_inflammation0.70894000
83MP0001873_stomach_inflammation0.70000760
84MP0000920_abnormal_myelination0.69814350
85MP0008874_decreased_physiological_sensi0.68709625
86MP0003795_abnormal_bone_structure0.67819633
87MP0000249_abnormal_blood_vessel0.63190222
88MP0001542_abnormal_bone_strength0.60607329
89MP0000490_abnormal_crypts_of0.56824434
90MP0003045_fibrosis0.55689666
91MP0003221_abnormal_cardiomyocyte_apopto0.55031248
92MP0005076_abnormal_cell_differentiation0.54509619
93MP0005319_abnormal_enzyme/_coenzyme0.54309257
94MP0003195_calcinosis0.54282378
95MP0005535_abnormal_body_temperature0.52978090
96MP0004381_abnormal_hair_follicle0.51660169
97MP0005381_digestive/alimentary_phenotyp0.49995090
98MP0002166_altered_tumor_susceptibility0.49668085
99MP0002693_abnormal_pancreas_physiology0.47328329
100MP0002006_tumorigenesis0.47151614

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.95900445
2Recurrent bacterial skin infections (HP:0005406)5.85526219
3Recurrent abscess formation (HP:0002722)5.72701900
4Abnormality of macrophages (HP:0004311)5.71507879
5Orchitis (HP:0100796)5.71273112
6Myositis (HP:0100614)5.65063731
7Optic neuritis (HP:0100653)5.60069542
8Retrobulbar optic neuritis (HP:0100654)5.60069542
9Stomatitis (HP:0010280)4.99413645
10Recurrent gram-negative bacterial infections (HP:0005420)4.66496616
11Abnormality of glycolipid metabolism (HP:0010969)4.45676640
12Abnormality of liposaccharide metabolism (HP:0010968)4.45676640
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.45676640
14Elevated erythrocyte sedimentation rate (HP:0003565)4.19527279
15Mediastinal lymphadenopathy (HP:0100721)4.16566758
16Keratoconjunctivitis sicca (HP:0001097)3.95590015
17Recurrent fungal infections (HP:0002841)3.64688111
18Keratoconjunctivitis (HP:0001096)3.63498394
19Recurrent skin infections (HP:0001581)3.62070862
20Chronic obstructive pulmonary disease (HP:0006510)3.60023978
21Obstructive lung disease (HP:0006536)3.60023978
22Increased cerebral lipofuscin (HP:0011813)3.56171029
23Gastrointestinal infarctions (HP:0005244)3.55050413
24Vasculitis (HP:0002633)3.40233560
25Meningitis (HP:0001287)3.39311534
26Loss of speech (HP:0002371)3.33979837
27Encephalitis (HP:0002383)3.29097922
28Systemic lupus erythematosus (HP:0002725)3.20530263
29Pulmonary infiltrates (HP:0002113)3.19680901
30Amyloidosis (HP:0011034)3.17654920
31Gingivitis (HP:0000230)3.15817139
32Hemoptysis (HP:0002105)3.14709904
33Disinhibition (HP:0000734)3.12010818
34Spontaneous hematomas (HP:0007420)3.08506415
35Dysostosis multiplex (HP:0000943)3.04047737
36Increased IgE level (HP:0003212)3.02333596
37Urticaria (HP:0001025)3.02197691
38Vacuolated lymphocytes (HP:0001922)2.95716534
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.89373440
40Recurrent cutaneous fungal infections (HP:0011370)2.89162171
41Chronic mucocutaneous candidiasis (HP:0002728)2.89162171
42Increased IgM level (HP:0003496)2.84373740
43Arterial thrombosis (HP:0004420)2.83462034
44Recurrent viral infections (HP:0004429)2.83160732
45Episodic fever (HP:0001954)2.83151826
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.80078139
47Autoimmune thrombocytopenia (HP:0001973)2.77660877
48T lymphocytopenia (HP:0005403)2.76426460
49Gangrene (HP:0100758)2.75351940
50Leukocytosis (HP:0001974)2.74626995
51Increased serum ferritin (HP:0003281)2.67915211
52Anorexia (HP:0002039)2.65033699
53Abnormality of T cell number (HP:0011839)2.63007435
54Chest pain (HP:0100749)2.60741049
55Petechiae (HP:0000967)2.57493023
56Prolonged bleeding time (HP:0003010)2.55464041
57Purpura (HP:0000979)2.55048399
58Pulmonary embolism (HP:0002204)2.54721992
59Cellulitis (HP:0100658)2.50632676
60Mutism (HP:0002300)2.49992402
61Hematochezia (HP:0002573)2.43024221
62Gingival bleeding (HP:0000225)2.39047906
63Abnormality of the pleura (HP:0002103)2.36306185
64Abnormality of polysaccharide metabolism (HP:0011012)2.34570475
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34570475
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34570475
67Polyneuropathy (HP:0001271)2.32978661
68Peritonitis (HP:0002586)2.31114593
69Hypergammaglobulinemia (HP:0010702)2.30567503
70Abnormality of iron homeostasis (HP:0011031)2.30375864
71Epistaxis (HP:0000421)2.29652659
72Inflammation of the large intestine (HP:0002037)2.24174025
73Vertigo (HP:0002321)2.24014044
74Hepatosplenomegaly (HP:0001433)2.18358262
75Urinary glycosaminoglycan excretion (HP:0003541)2.16449266
76Mucopolysacchariduria (HP:0008155)2.16449266
77Gastrointestinal inflammation (HP:0004386)2.12958396
78Pustule (HP:0200039)2.12187653
79Glomerulopathy (HP:0100820)2.11370711
80Abnormality of the endocardium (HP:0004306)2.10561646
81Acne (HP:0001061)2.10079710
82Colitis (HP:0002583)2.09847741
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09392158
84Interstitial pulmonary disease (HP:0006530)2.05818780
85Osteomyelitis (HP:0002754)2.05452174
86Granulocytopenia (HP:0001913)2.04218042
87Malnutrition (HP:0004395)2.03568535
88Abnormality of the pericardium (HP:0001697)2.00709166
89Abnormality of T cells (HP:0002843)2.00061882
90Sepsis (HP:0100806)1.98882040
91Keratitis (HP:0000491)1.97941072
92Neuronal loss in central nervous system (HP:0002529)1.97772703
93Progressive neurologic deterioration (HP:0002344)1.97750767
94Glomerulonephritis (HP:0000099)1.93298543
95Memory impairment (HP:0002354)1.92653006
96Autoimmune hemolytic anemia (HP:0001890)1.91489846
97Premature loss of primary teeth (HP:0006323)1.91171069
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90431094
99Arthralgia (HP:0002829)1.89814148
100Lymphopenia (HP:0001888)1.89552783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.44158981
2BLK3.38340447
3MAP4K13.13628819
4TYK23.07827956
5IRAK43.02778934
6CSK2.74832631
7MAP3K142.62014675
8IRAK32.60592855
9MAP2K32.50649506
10PRPF4B2.43711478
11ERN12.38679098
12FGR2.26236753
13TBK12.10971658
14MATK2.03242637
15TAOK12.00434857
16JAK31.99387513
17IKBKE1.98647561
18FES1.98067356
19TXK1.94698906
20GRK71.94080621
21MAP3K31.91619127
22ZAP701.90945275
23MAP3K111.85097809
24TAOK21.73125929
25TNK21.65428642
26MAP3K131.60985844
27SYK1.54644193
28IKBKB1.54578132
29JAK11.47768794
30BTK1.41346848
31HCK1.40726696
32BMPR21.39324111
33EPHB11.38194200
34LYN1.37545092
35JAK21.35467378
36TGFBR21.33864160
37CSF1R1.28567649
38MAP3K11.28233311
39SIK31.24078002
40GRK61.21039215
41IRAK11.16176882
42CDC42BPA1.13343835
43IRAK21.12727804
44LCK1.08673146
45NME21.07372973
46KIT1.07010506
47DDR21.05909566
48RIPK11.03075720
49MOS1.02516408
50MARK31.00804411
51TAOK31.00680028
52KSR20.89762312
53STK100.87354030
54YES10.75001833
55MAP3K50.73308357
56MARK20.72417040
57PDK10.71832049
58ITK0.69763568
59CHUK0.68540054
60SIK20.65925499
61PDPK10.64357389
62TEC0.63486078
63TESK20.61237577
64MAPK70.59456482
65PRKD20.55557375
66EPHA30.55535160
67FYN0.53881028
68DAPK20.51881320
69HIPK20.50858934
70FGFR40.49950735
71PIM10.49558070
72TRIB30.47925215
73ADRBK20.47869861
74CAMKK20.45461309
75MAP2K60.45401874
76PTK60.44405099
77RPS6KC10.42019138
78RPS6KL10.42019138
79FGFR30.41219956
80SIK10.40894127
81MAP3K60.40882638
82DYRK1B0.40803270
83MAPK120.40166323
84ACVR1B0.39184701
85TYRO30.36616690
86DYRK30.35158837
87RPS6KA60.33934527
88PRKCQ0.32483209
89PIM20.31529842
90CDK60.31269765
91SGK30.31225094
92KSR10.31114980
93MAPK40.30307578
94ABL10.30085214
95LRRK20.29214843
96MAPKAPK20.27438324
97BMX0.26671090
98PRKCD0.25174401
99STK110.24625574
100CLK10.23104216

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.01092035
2* Osteoclast differentiation_Homo sapiens_hsa043803.00867829
3Staphylococcus aureus infection_Homo sapiens_hsa051502.93386610
4Allograft rejection_Homo sapiens_hsa053302.66546667
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60966512
6Graft-versus-host disease_Homo sapiens_hsa053322.52649909
7Autoimmune thyroid disease_Homo sapiens_hsa053202.28095492
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.27489897
9Tuberculosis_Homo sapiens_hsa051522.24951576
10Malaria_Homo sapiens_hsa051442.22107543
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10678348
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.10590146
13Other glycan degradation_Homo sapiens_hsa005112.06794199
14Asthma_Homo sapiens_hsa053102.01807713
15Legionellosis_Homo sapiens_hsa051341.95152421
16Rheumatoid arthritis_Homo sapiens_hsa053231.92963703
17Type I diabetes mellitus_Homo sapiens_hsa049401.92317860
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.83477151
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82269925
20B cell receptor signaling pathway_Homo sapiens_hsa046621.82071584
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81556290
22TNF signaling pathway_Homo sapiens_hsa046681.78421433
23Pertussis_Homo sapiens_hsa051331.74581023
24Influenza A_Homo sapiens_hsa051641.71076755
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68818252
26African trypanosomiasis_Homo sapiens_hsa051431.68392381
27Antigen processing and presentation_Homo sapiens_hsa046121.64237376
28Toxoplasmosis_Homo sapiens_hsa051451.64070191
29Measles_Homo sapiens_hsa051621.62706880
30Hematopoietic cell lineage_Homo sapiens_hsa046401.59170573
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58219308
32Lysosome_Homo sapiens_hsa041421.57160844
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57027805
34Primary immunodeficiency_Homo sapiens_hsa053401.52573798
35Chemokine signaling pathway_Homo sapiens_hsa040621.52144729
36Viral myocarditis_Homo sapiens_hsa054161.46932805
37Phagosome_Homo sapiens_hsa041451.42119194
38Herpes simplex infection_Homo sapiens_hsa051681.40972844
39Salmonella infection_Homo sapiens_hsa051321.40021120
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37830832
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.31449262
42Acute myeloid leukemia_Homo sapiens_hsa052211.31269056
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30503828
44T cell receptor signaling pathway_Homo sapiens_hsa046601.24717889
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16159391
46Hepatitis C_Homo sapiens_hsa051601.15192252
47Hepatitis B_Homo sapiens_hsa051611.12297722
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.10092965
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07333081
50Shigellosis_Homo sapiens_hsa051311.04991483
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97635750
52Apoptosis_Homo sapiens_hsa042100.87533039
53Amoebiasis_Homo sapiens_hsa051460.82397515
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.81098613
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80526721
56Prolactin signaling pathway_Homo sapiens_hsa049170.79171108
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.77918580
58Platelet activation_Homo sapiens_hsa046110.75894700
59VEGF signaling pathway_Homo sapiens_hsa043700.75370401
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71804125
61Epstein-Barr virus infection_Homo sapiens_hsa051690.71394670
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69093937
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.63814939
64Prion diseases_Homo sapiens_hsa050200.63103651
65Pancreatic cancer_Homo sapiens_hsa052120.62757170
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62459262
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.62458260
68Chronic myeloid leukemia_Homo sapiens_hsa052200.60263499
69Non-small cell lung cancer_Homo sapiens_hsa052230.59637977
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59187114
71Bladder cancer_Homo sapiens_hsa052190.58635612
72Type II diabetes mellitus_Homo sapiens_hsa049300.54580626
73Endocytosis_Homo sapiens_hsa041440.52135793
74Renal cell carcinoma_Homo sapiens_hsa052110.50573941
75Collecting duct acid secretion_Homo sapiens_hsa049660.50302888
76Notch signaling pathway_Homo sapiens_hsa043300.49526966
77HIF-1 signaling pathway_Homo sapiens_hsa040660.46006386
78HTLV-I infection_Homo sapiens_hsa051660.45583143
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.45145051
80Complement and coagulation cascades_Homo sapiens_hsa046100.43821666
81Dorso-ventral axis formation_Homo sapiens_hsa043200.42866020
82FoxO signaling pathway_Homo sapiens_hsa040680.42802328
83Viral carcinogenesis_Homo sapiens_hsa052030.42428244
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41517834
85GnRH signaling pathway_Homo sapiens_hsa049120.39359271
86Insulin resistance_Homo sapiens_hsa049310.36362878
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35189317
88MAPK signaling pathway_Homo sapiens_hsa040100.32710939
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28901929
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28484772
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27826857
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26697396
93mTOR signaling pathway_Homo sapiens_hsa041500.26386377
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23919127
95Endometrial cancer_Homo sapiens_hsa052130.22990297
96Choline metabolism in cancer_Homo sapiens_hsa052310.22545354
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21354278
98Rap1 signaling pathway_Homo sapiens_hsa040150.20266261
99Sphingolipid metabolism_Homo sapiens_hsa006000.19216078
100ErbB signaling pathway_Homo sapiens_hsa040120.16825727

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