LILRB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.53856403
2response to peptidoglycan (GO:0032494)5.06128852
3immunoglobulin mediated immune response (GO:0016064)4.41427203
4regulation of vitamin D biosynthetic process (GO:0060556)4.38319152
5regulation of mononuclear cell migration (GO:0071675)4.37749752
6neutrophil activation involved in immune response (GO:0002283)4.37735163
7macrophage activation involved in immune response (GO:0002281)4.30005963
8positive regulation of gamma-delta T cell activation (GO:0046645)4.11995063
9lipopolysaccharide-mediated signaling pathway (GO:0031663)4.07924589
10glycosphingolipid catabolic process (GO:0046479)4.04857984
11regulation of T-helper 1 cell differentiation (GO:0045625)3.97253001
12oligosaccharide catabolic process (GO:0009313)3.77667202
13T-helper 1 type immune response (GO:0042088)3.77403582
14type I interferon signaling pathway (GO:0060337)3.76590111
15cellular response to type I interferon (GO:0071357)3.76590111
16interferon-gamma-mediated signaling pathway (GO:0060333)3.76531648
17response to type I interferon (GO:0034340)3.71760887
18regulation of cytokine secretion involved in immune response (GO:0002739)3.69735129
19cellular response to thyroid hormone stimulus (GO:0097067)3.68267381
20positive regulation by symbiont of host defense response (GO:0052509)3.66379388
21modulation by symbiont of host defense response (GO:0052031)3.66379388
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66379388
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66379388
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.66379388
25modulation by symbiont of host immune response (GO:0052553)3.66379388
26glycolipid catabolic process (GO:0019377)3.62710680
27regulation of interferon-alpha production (GO:0032647)3.59905011
28myeloid dendritic cell differentiation (GO:0043011)3.59237517
29positive regulation of chemokine biosynthetic process (GO:0045080)3.57606363
30positive regulation of antigen processing and presentation (GO:0002579)3.52121464
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.44114725
32regulation of vitamin metabolic process (GO:0030656)3.42124377
33regulation of antigen processing and presentation (GO:0002577)3.40945096
34amino sugar catabolic process (GO:0046348)3.40509003
35negative regulation of cytokine production involved in immune response (GO:0002719)3.40125464
36positive regulation of type 2 immune response (GO:0002830)3.40005464
37defense response to protozoan (GO:0042832)3.36686783
38NIK/NF-kappaB signaling (GO:0038061)3.34404400
39regulation of chronic inflammatory response (GO:0002676)3.32888178
40response to protozoan (GO:0001562)3.30910349
41negative regulation of nitric oxide biosynthetic process (GO:0045019)3.30617452
42regulation of podosome assembly (GO:0071801)3.30316680
43negative regulation of cell killing (GO:0031342)3.29703967
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.29703967
45regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.28548851
46monocyte chemotaxis (GO:0002548)3.27485213
47detection of molecule of bacterial origin (GO:0032490)3.26766079
48ceramide catabolic process (GO:0046514)3.25795537
49positive regulation of heat generation (GO:0031652)3.25547272
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25053698
51B cell mediated immunity (GO:0019724)3.24453134
52myeloid dendritic cell activation (GO:0001773)3.22472705
53germinal center formation (GO:0002467)3.22084155
54regulation of chemokine biosynthetic process (GO:0045073)3.20927997
55granulocyte activation (GO:0036230)3.20831198
56regulation of interleukin-12 production (GO:0032655)3.18173188
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15441088
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.13201022
59regulation of macrophage chemotaxis (GO:0010758)3.09755796
60regulation of interferon-beta biosynthetic process (GO:0045357)3.09604093
61positive regulation of interferon-alpha production (GO:0032727)3.08731517
62negative regulation of myeloid cell apoptotic process (GO:0033033)3.06171888
63cellular response to interferon-gamma (GO:0071346)3.06009956
64dendritic cell differentiation (GO:0097028)3.05665304
65macrophage activation (GO:0042116)3.01787058
66regulation of T cell tolerance induction (GO:0002664)3.00598034
67cellular response to lipopolysaccharide (GO:0071222)3.00452769
68myeloid cell activation involved in immune response (GO:0002275)2.99702454
69regulation of fever generation (GO:0031620)2.99631262
70detection of other organism (GO:0098543)2.99151954
71eosinophil chemotaxis (GO:0048245)2.98424522
72response to interferon-gamma (GO:0034341)2.96418171
73regulation of cholesterol storage (GO:0010885)2.95242287
74positive regulation of toll-like receptor signaling pathway (GO:0034123)2.95155208
75regulation of mast cell degranulation (GO:0043304)2.94903811
76cellular response to molecule of bacterial origin (GO:0071219)2.94872640
77cellular extravasation (GO:0045123)2.94141555
78positive regulation of monocyte chemotaxis (GO:0090026)2.94088486
79response to muramyl dipeptide (GO:0032495)2.93818490
80lymphocyte chemotaxis (GO:0048247)2.93649659
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.92670243
82positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.90555937
83regulation of inflammatory response to antigenic stimulus (GO:0002861)2.89835069
84positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89289309
85positive regulation of mast cell degranulation (GO:0043306)2.89046181
86positive regulation of mast cell activation involved in immune response (GO:0033008)2.89046181
87regulation of gamma-delta T cell activation (GO:0046643)2.87874673
88negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.87257637
89membrane lipid catabolic process (GO:0046466)2.86130137
90regulation of T-helper 2 cell differentiation (GO:0045628)2.85308531
91positive regulation of mast cell activation (GO:0033005)2.85297768
92positive regulation of cellular amide metabolic process (GO:0034250)2.84806405
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83954655
94T cell migration (GO:0072678)2.83844313
95detection of external biotic stimulus (GO:0098581)2.82024553
96response to thyroid hormone (GO:0097066)2.80992641
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80596829
98branching involved in labyrinthine layer morphogenesis (GO:0060670)2.78869537
99positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78688969
100regulation of type 2 immune response (GO:0002828)2.78468335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.69851239
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.77132958
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.96448456
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.24928376
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.88426713
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.81667410
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.74395959
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.43542197
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28841160
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21767013
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.02316631
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92707579
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84564185
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68972299
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54289441
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52607333
17* VDR_24787735_ChIP-Seq_THP-1_Human2.45510029
18* VDR_24763502_ChIP-Seq_THP-1_Human2.26025573
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.22058530
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21002737
21SPI1_23127762_ChIP-Seq_K562_Human2.20962569
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08892855
23SPI1_23547873_ChIP-Seq_NB4_Human2.08725347
24* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05307059
25VDR_21846776_ChIP-Seq_THP-1_Human2.00899836
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96738883
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91801942
28SCL_19346495_ChIP-Seq_HPC-7_Human1.83221788
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.81763945
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74390620
31* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67443528
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66101966
33RUNX_20019798_ChIP-Seq_JUKART_Human1.58096409
34* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56713613
35GATA1_22025678_ChIP-Seq_K562_Human1.55784921
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54000156
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52972864
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52778854
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.51329605
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.50023351
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47657674
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46605153
43* PU_27001747_Chip-Seq_BMDM_Mouse1.45764667
44MYB_26560356_Chip-Seq_TH2_Human1.39606637
45MAF_26560356_Chip-Seq_TH1_Human1.38214143
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38204489
47* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38069928
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32841897
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32356889
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30892735
51* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28482998
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27074489
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.25506403
54LXR_22292898_ChIP-Seq_THP-1_Human1.24821873
55* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23344961
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23092489
57* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22939599
58* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22473463
59* STAT1_20625510_ChIP-Seq_HELA_Human1.14605953
60* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13897850
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11348299
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08804560
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07394483
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.06862715
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06752550
66TFEB_21752829_ChIP-Seq_HELA_Human1.05909690
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04856987
68GATA1_19941826_ChIP-Seq_K562_Human1.04328645
69MYB_26560356_Chip-Seq_TH1_Human1.03963774
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.03932306
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03878932
72UTX_26944678_Chip-Seq_JUKART_Human1.03502489
73GATA3_26560356_Chip-Seq_TH2_Human1.02455633
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02337460
75GATA3_27048872_Chip-Seq_THYMUS_Human1.01595145
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01175892
77KDM2B_26808549_Chip-Seq_DND41_Human0.97335603
78ESR2_21235772_ChIP-Seq_MCF-7_Human0.97059845
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96581803
80TCF7_22412390_ChIP-Seq_EML_Mouse0.95309760
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94033030
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93239329
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91633236
84MAF_26560356_Chip-Seq_TH2_Human0.91606214
85BCL6_27268052_Chip-Seq_Bcells_Human0.90556815
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87228891
87EGR1_19032775_ChIP-ChIP_M12_Human0.87090411
88BCOR_27268052_Chip-Seq_Bcells_Human0.86616385
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84333398
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79663717
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78258888
92MYC_22102868_ChIP-Seq_BL_Human0.77046591
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76039200
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75348817
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75134886
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.72817376
97RXR_22158963_ChIP-Seq_LIVER_Mouse0.72039566
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70255359
99GATA2_19941826_ChIP-Seq_K562_Human0.69807224
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68657918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.80306783
2MP0006082_CNS_inflammation3.81209333
3MP0005058_abnormal_lysosome_morphology3.80061047
4MP0003724_increased_susceptibility_to3.43907748
5* MP0002148_abnormal_hypersensitivity_rea3.37465195
6MP0009785_altered_susceptibility_to3.28877434
7MP0003436_decreased_susceptibility_to3.26296591
8MP0009840_abnormal_foam_cell3.07473632
9* MP0001835_abnormal_antigen_presentation3.02664963
10MP0002419_abnormal_innate_immunity2.80545956
11MP0005000_abnormal_immune_tolerance2.71283705
12MP0004510_myositis2.70022496
13MP0003172_abnormal_lysosome_physiology2.61894704
14MP0005025_abnormal_response_to2.60935354
15* MP0005387_immune_system_phenotype2.54668820
16* MP0001790_abnormal_immune_system2.54668820
17* MP0005671_abnormal_response_to2.48019662
18MP0002139_abnormal_hepatobiliary_system2.40646717
19MP0003300_gastrointestinal_ulcer2.38575575
20MP0009764_decreased_sensitivity_to2.29196990
21* MP0002452_abnormal_antigen_presenting2.26043149
22MP0000343_altered_response_to2.25016257
23MP0000604_amyloidosis2.23356344
24* MP0002723_abnormal_immune_serum2.16838681
25MP0003075_altered_response_to2.16389324
26* MP0001800_abnormal_humoral_immune2.13161821
27MP0003191_abnormal_cellular_cholesterol2.10552157
28MP0000685_abnormal_immune_system2.06388781
29MP0001533_abnormal_skeleton_physiology2.03816937
30MP0009278_abnormal_bone_marrow2.03312940
31MP0005167_abnormal_blood-brain_barrier1.85472900
32MP0005451_abnormal_body_composition1.84371391
33* MP0001819_abnormal_immune_cell1.82439904
34* MP0002420_abnormal_adaptive_immunity1.82199879
35MP0001853_heart_inflammation1.81571782
36* MP0001845_abnormal_inflammatory_respons1.78747208
37MP0005310_abnormal_salivary_gland1.75506115
38MP0003806_abnormal_nucleotide_metabolis1.70080884
39MP0003690_abnormal_glial_cell1.68057699
40MP0004947_skin_inflammation1.67960298
41MP0002998_abnormal_bone_remodeling1.66725393
42MP0010155_abnormal_intestine_physiology1.62032556
43* MP0008469_abnormal_protein_level1.61838915
44MP0002254_reproductive_system_inflammat1.61219290
45MP0002405_respiratory_system_inflammati1.60704354
46MP0005397_hematopoietic_system_phenotyp1.58267476
47MP0001545_abnormal_hematopoietic_system1.58267476
48MP0003448_altered_tumor_morphology1.49127641
49MP0006054_spinal_hemorrhage1.44371966
50MP0005464_abnormal_platelet_physiology1.42154464
51MP0009333_abnormal_splenocyte_physiolog1.41224716
52MP0008004_abnormal_stomach_pH1.40754290
53MP0003195_calcinosis1.33671762
54MP0005166_decreased_susceptibility_to1.32924165
55MP0003453_abnormal_keratinocyte_physiol1.28031777
56* MP0000716_abnormal_immune_system1.26402922
57MP0000858_altered_metastatic_potential1.20267710
58MP0002332_abnormal_exercise_endurance1.13053766
59MP0000920_abnormal_myelination1.11158095
60MP0003656_abnormal_erythrocyte_physiolo1.09629642
61MP0003329_amyloid_beta_deposits1.08856801
62MP0002398_abnormal_bone_marrow1.00584666
63MP0005164_abnormal_response_to0.96654063
64MP0009763_increased_sensitivity_to0.96124812
65MP0000689_abnormal_spleen_morphology0.94093024
66* MP0002429_abnormal_blood_cell0.93655531
67MP0002138_abnormal_hepatobiliary_system0.92039596
68MP0003183_abnormal_peptide_metabolism0.90918903
69MP0003828_pulmonary_edema0.89850951
70MP0004883_abnormal_blood_vessel0.87327886
71MP0005390_skeleton_phenotype0.83334418
72MP0001663_abnormal_digestive_system0.81614739
73MP0002722_abnormal_immune_system0.80323462
74MP0008260_abnormal_autophagy0.80079188
75MP0005365_abnormal_bile_salt0.79090070
76MP0002837_dystrophic_cardiac_calcinosis0.78065393
77MP0005647_abnormal_sex_gland0.77679421
78MP0005165_increased_susceptibility_to0.76016150
79MP0009765_abnormal_xenobiotic_induced0.74897791
80MP0001542_abnormal_bone_strength0.74833775
81MP0003795_abnormal_bone_structure0.73310155
82MP0002277_abnormal_respiratory_mucosa0.72469172
83MP0008874_decreased_physiological_sensi0.69518698
84MP0003091_abnormal_cell_migration0.69016281
85MP0003646_muscle_fatigue0.67320699
86MP0000249_abnormal_blood_vessel0.66889673
87MP0002933_joint_inflammation0.66796190
88MP0000371_diluted_coat_color0.66348016
89MP0001501_abnormal_sleep_pattern0.64871850
90MP0003763_abnormal_thymus_physiology0.60588758
91MP0010307_abnormal_tumor_latency0.58713374
92MP0000465_gastrointestinal_hemorrhage0.58448390
93MP0005319_abnormal_enzyme/_coenzyme0.57957870
94MP0003634_abnormal_glial_cell0.56627979
95MP0002090_abnormal_vision0.56395300
96MP0005535_abnormal_body_temperature0.52733240
97MP0005595_abnormal_vascular_smooth0.52329437
98MP0001851_eye_inflammation0.51930080
99MP0003633_abnormal_nervous_system0.51726850
100MP0000609_abnormal_liver_physiology0.51666070

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.81097586
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.81097586
3Abnormality of glycolipid metabolism (HP:0010969)7.81097586
4Increased cerebral lipofuscin (HP:0011813)5.44698904
5Systemic lupus erythematosus (HP:0002725)5.31051161
6Abnormality of macrophages (HP:0004311)5.11370773
7Vacuolated lymphocytes (HP:0001922)5.07729461
8Recurrent bacterial skin infections (HP:0005406)4.68978303
9Disinhibition (HP:0000734)4.59617970
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.56779941
11Dysostosis multiplex (HP:0000943)4.53685106
12Loss of speech (HP:0002371)4.48211616
13Recurrent abscess formation (HP:0002722)4.41615354
14Retrobulbar optic neuritis (HP:0100654)4.19329349
15Optic neuritis (HP:0100653)4.19329349
16Orchitis (HP:0100796)4.18606739
17Eczematoid dermatitis (HP:0000976)4.13328954
18Mutism (HP:0002300)4.03175515
19Myositis (HP:0100614)3.88896811
20Stomatitis (HP:0010280)3.78915032
21Autoimmune thrombocytopenia (HP:0001973)3.68443771
22Mediastinal lymphadenopathy (HP:0100721)3.61234841
23Abnormality of polysaccharide metabolism (HP:0011012)3.51965223
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.51965223
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.51965223
26Recurrent gram-negative bacterial infections (HP:0005420)3.50819753
27Glomerulonephritis (HP:0000099)3.42998906
28Neurofibrillary tangles (HP:0002185)3.30737825
29Mucopolysacchariduria (HP:0008155)3.25954890
30Urinary glycosaminoglycan excretion (HP:0003541)3.25954890
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.12902251
32Nuclear cataract (HP:0100018)3.04477950
33Axonal loss (HP:0003447)2.97402757
34Keratoconjunctivitis sicca (HP:0001097)2.84200014
35Increased serum ferritin (HP:0003281)2.83512884
36Apathy (HP:0000741)2.80097300
37Pulmonary infiltrates (HP:0002113)2.78028861
38Diminished motivation (HP:0000745)2.76827911
39Recurrent skin infections (HP:0001581)2.74400312
40Hematochezia (HP:0002573)2.72440885
41Purpura (HP:0000979)2.71800670
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70823269
43Agnosia (HP:0010524)2.70588718
44Obstructive lung disease (HP:0006536)2.67426272
45Chronic obstructive pulmonary disease (HP:0006510)2.67426272
46Inappropriate behavior (HP:0000719)2.67065337
47Hemoptysis (HP:0002105)2.63319006
48Keratoconjunctivitis (HP:0001096)2.62295255
49Amyloidosis (HP:0011034)2.59167538
50Myocardial infarction (HP:0001658)2.58218125
51Neuronal loss in central nervous system (HP:0002529)2.56908288
52Abnormality of the vasculature of the conjunctiva (HP:0008054)2.55308835
53Vasculitis (HP:0002633)2.54999528
54Complement deficiency (HP:0004431)2.53945218
55Recurrent fungal infections (HP:0002841)2.52526565
56Metaphyseal irregularity (HP:0003025)2.50837519
57Progressive neurologic deterioration (HP:0002344)2.49182449
58Increased IgM level (HP:0003496)2.42364565
59Elevated erythrocyte sedimentation rate (HP:0003565)2.41899803
60Upper motor neuron abnormality (HP:0002127)2.35369715
61Gangrene (HP:0100758)2.31753574
62Petechiae (HP:0000967)2.31339048
63Abnormality of iron homeostasis (HP:0011031)2.30206893
64Hepatosplenomegaly (HP:0001433)2.28339653
65Cerebral inclusion bodies (HP:0100314)2.28219916
66Polyneuropathy (HP:0001271)2.26492004
67Recurrent viral infections (HP:0004429)2.26332836
68Gingivitis (HP:0000230)2.25715868
69Meningitis (HP:0001287)2.22495715
70Basal ganglia calcification (HP:0002135)2.21675833
71T lymphocytopenia (HP:0005403)2.18669664
72Malnutrition (HP:0004395)2.12285897
73Personality changes (HP:0000751)2.10423233
74Encephalitis (HP:0002383)2.08553687
75Dementia (HP:0000726)2.08181077
76Spontaneous hematomas (HP:0007420)2.06556581
77Interstitial pulmonary disease (HP:0006530)2.05221585
78Urticaria (HP:0001025)2.03512649
79Memory impairment (HP:0002354)2.03408322
80Prolonged neonatal jaundice (HP:0006579)2.02250220
81Abnormality of T cell number (HP:0011839)2.01400816
82Recurrent cutaneous fungal infections (HP:0011370)1.99876170
83Chronic mucocutaneous candidiasis (HP:0002728)1.99876170
84Abnormality of complement system (HP:0005339)1.96786365
85Nausea (HP:0002018)1.92508847
86Arterial thrombosis (HP:0004420)1.90884342
87Asymmetric septal hypertrophy (HP:0001670)1.90813433
88Pulmonary embolism (HP:0002204)1.90350548
89Abnormality of the periventricular white matter (HP:0002518)1.90263494
90Abnormality of transition element cation homeostasis (HP:0011030)1.90208383
91Peripheral demyelination (HP:0011096)1.89964602
92Hypergammaglobulinemia (HP:0010702)1.88930902
93Retinal atrophy (HP:0001105)1.88424215
94Gastrointestinal infarctions (HP:0005244)1.87631476
95Premature loss of primary teeth (HP:0006323)1.85021106
96Parakeratosis (HP:0001036)1.84943648
97Abnormality of the pleura (HP:0002103)1.84863040
98Anorexia (HP:0002039)1.83702989
99Vertigo (HP:0002321)1.83427823
100Pathologic fracture (HP:0002756)1.83136606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.43208081
2BLK3.61749142
3GRK73.53871446
4NME23.30070077
5MAP3K143.18155596
6RIPK43.01566406
7TYK22.84727330
8TBK12.57102370
9MATK2.52635833
10DDR22.48910305
11TAOK22.26879021
12IRAK42.26644711
13FGR2.26302427
14MAP4K12.25589709
15TGFBR22.24830062
16CSK2.14849318
17IKBKE2.08060697
18IKBKB2.06008127
19MAP3K111.92421700
20ADRBK21.90137414
21TXK1.77809858
22JAK31.76984454
23TAOK11.76475505
24PRPF4B1.74683959
25ERN11.72742156
26ACVR1B1.71372682
27MAP3K31.67498336
28MOS1.56826181
29BMPR21.54704043
30RIPK11.54327680
31MAP2K31.48678770
32CDC42BPA1.44767764
33CSF1R1.44338288
34PIM21.40967268
35JAK11.35006847
36ZAP701.34267967
37SYK1.31546822
38LYN1.28572908
39MAP3K131.24207055
40KIT1.20660888
41ABL21.11447117
42CHUK1.08898510
43JAK21.04937388
44IRAK11.02163669
45FES1.00342964
46MAP3K10.95812757
47IRAK20.94165508
48MARK30.93876022
49CAMKK20.87844444
50HCK0.87542002
51LCK0.87393946
52BTK0.82912440
53TNK20.80268281
54MAP3K50.79283312
55MAP2K60.71736171
56TAOK30.69860695
57SIK30.68406884
58TYRO30.68033436
59TESK20.67625201
60CAMK1D0.64148297
61STK100.63835053
62DAPK20.63396370
63CLK10.51979234
64PDK10.49895168
65PIM10.47302845
66CDK60.47124258
67MAPK40.46790427
68PDPK10.46112221
69ABL10.45616864
70MAPK70.42696916
71RPS6KL10.42105957
72RPS6KC10.42105957
73ITK0.40434567
74NEK90.40228849
75PKN10.39096134
76DYRK30.36523605
77RPS6KA60.36429068
78EPHA30.34106734
79HIPK20.33189935
80PDK20.32862060
81SIK20.31952069
82TGFBR10.31429862
83EGFR0.31300469
84FYN0.30563332
85TESK10.30485087
86ARAF0.29634401
87LATS20.28739057
88TEC0.28603491
89BMX0.27823322
90INSR0.27157203
91PRKCD0.25166656
92RPS6KA20.23591473
93MAPKAPK20.23134583
94PRKCQ0.19953599
95MAPK120.18795437
96MARK20.17760947
97PDGFRB0.17642007
98EPHB10.17517018
99GSK3A0.17057306
100PDGFRA0.15432921

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.29124270
2Other glycan degradation_Homo sapiens_hsa005113.19890010
3Allograft rejection_Homo sapiens_hsa053302.95063948
4Asthma_Homo sapiens_hsa053102.95035815
5Lysosome_Homo sapiens_hsa041422.91337356
6Rheumatoid arthritis_Homo sapiens_hsa053232.89360549
7Leishmaniasis_Homo sapiens_hsa051402.72478124
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.71588480
9* Osteoclast differentiation_Homo sapiens_hsa043802.65730181
10Graft-versus-host disease_Homo sapiens_hsa053322.58914525
11Autoimmune thyroid disease_Homo sapiens_hsa053202.47099276
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.43610803
13Tuberculosis_Homo sapiens_hsa051522.25975458
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19281071
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.18974238
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.08520390
17Pertussis_Homo sapiens_hsa051332.05879319
18Type I diabetes mellitus_Homo sapiens_hsa049402.05792844
19Malaria_Homo sapiens_hsa051442.05070597
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97982977
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91494821
22TNF signaling pathway_Homo sapiens_hsa046681.86744609
23Legionellosis_Homo sapiens_hsa051341.82970543
24Antigen processing and presentation_Homo sapiens_hsa046121.79950414
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79665094
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70874684
27Phagosome_Homo sapiens_hsa041451.66847182
28Influenza A_Homo sapiens_hsa051641.58434527
29Toxoplasmosis_Homo sapiens_hsa051451.56566363
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52367958
31African trypanosomiasis_Homo sapiens_hsa051431.48866715
32Hematopoietic cell lineage_Homo sapiens_hsa046401.47817844
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46650263
34Salmonella infection_Homo sapiens_hsa051321.46209640
35Viral myocarditis_Homo sapiens_hsa054161.39912656
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35210869
37B cell receptor signaling pathway_Homo sapiens_hsa046621.23109978
38Herpes simplex infection_Homo sapiens_hsa051681.22206847
39Chemokine signaling pathway_Homo sapiens_hsa040621.19908805
40Collecting duct acid secretion_Homo sapiens_hsa049661.18774517
41Measles_Homo sapiens_hsa051621.18247302
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16034996
43Prion diseases_Homo sapiens_hsa050201.02130450
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.02048853
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00485597
46Hepatitis C_Homo sapiens_hsa051600.99978589
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96008502
48Primary immunodeficiency_Homo sapiens_hsa053400.92631435
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91629520
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88789291
51Complement and coagulation cascades_Homo sapiens_hsa046100.84608731
52Sphingolipid metabolism_Homo sapiens_hsa006000.82662524
53Hepatitis B_Homo sapiens_hsa051610.80930137
54Shigellosis_Homo sapiens_hsa051310.80408486
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77463077
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76005290
57Apoptosis_Homo sapiens_hsa042100.74818775
58Mineral absorption_Homo sapiens_hsa049780.72956226
59Amoebiasis_Homo sapiens_hsa051460.69401845
60T cell receptor signaling pathway_Homo sapiens_hsa046600.69380621
61Bladder cancer_Homo sapiens_hsa052190.66935196
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66920516
63Acute myeloid leukemia_Homo sapiens_hsa052210.66803642
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.58979045
65Epstein-Barr virus infection_Homo sapiens_hsa051690.58383210
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57952139
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.52666002
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51064715
69Vibrio cholerae infection_Homo sapiens_hsa051100.50796393
70Prolactin signaling pathway_Homo sapiens_hsa049170.50746507
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46123118
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.45523094
73Systemic lupus erythematosus_Homo sapiens_hsa053220.42898467
74VEGF signaling pathway_Homo sapiens_hsa043700.40957742
75PPAR signaling pathway_Homo sapiens_hsa033200.40874102
76Type II diabetes mellitus_Homo sapiens_hsa049300.37541893
77Sulfur metabolism_Homo sapiens_hsa009200.35636772
78Galactose metabolism_Homo sapiens_hsa000520.35229122
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.33273357
80Tryptophan metabolism_Homo sapiens_hsa003800.33247845
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32961778
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.29562910
83HTLV-I infection_Homo sapiens_hsa051660.29188410
84Platelet activation_Homo sapiens_hsa046110.28930481
85HIF-1 signaling pathway_Homo sapiens_hsa040660.24319175
86Fructose and mannose metabolism_Homo sapiens_hsa000510.23527903
87Endocytosis_Homo sapiens_hsa041440.22052372
88Renin-angiotensin system_Homo sapiens_hsa046140.16849291
89Notch signaling pathway_Homo sapiens_hsa043300.15913155
90Synaptic vesicle cycle_Homo sapiens_hsa047210.15376008
91Dorso-ventral axis formation_Homo sapiens_hsa043200.14679367
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.14325335
93Viral carcinogenesis_Homo sapiens_hsa052030.13936822
94Ether lipid metabolism_Homo sapiens_hsa005650.11821455
95Insulin resistance_Homo sapiens_hsa049310.11616177
96GnRH signaling pathway_Homo sapiens_hsa049120.11268397
97Pancreatic cancer_Homo sapiens_hsa052120.11136080
98MAPK signaling pathway_Homo sapiens_hsa040100.10003141
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07816820
100Chronic myeloid leukemia_Homo sapiens_hsa052200.04557831

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »