LILRB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.33904094
2response to peptidoglycan (GO:0032494)4.59525898
3regulation of mononuclear cell migration (GO:0071675)4.50096740
4neutrophil activation involved in immune response (GO:0002283)4.28320638
5macrophage activation involved in immune response (GO:0002281)4.23844176
6immunoglobulin mediated immune response (GO:0016064)3.97568963
7T-helper 1 type immune response (GO:0042088)3.81181983
8regulation of vitamin D biosynthetic process (GO:0060556)3.74424066
9positive regulation of chemokine biosynthetic process (GO:0045080)3.72098462
10positive regulation of heat generation (GO:0031652)3.70411948
11lipopolysaccharide-mediated signaling pathway (GO:0031663)3.68344102
12regulation of cytokine secretion involved in immune response (GO:0002739)3.66734339
13positive regulation of gamma-delta T cell activation (GO:0046645)3.63163834
14negative regulation of cytokine production involved in immune response (GO:0002719)3.57082646
15positive regulation by symbiont of host defense response (GO:0052509)3.51049466
16modulation by symbiont of host defense response (GO:0052031)3.51049466
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51049466
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51049466
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.51049466
20modulation by symbiont of host immune response (GO:0052553)3.51049466
21glycosphingolipid catabolic process (GO:0046479)3.49162642
22oligosaccharide catabolic process (GO:0009313)3.41029485
23amino sugar catabolic process (GO:0046348)3.37539478
24detection of molecule of bacterial origin (GO:0032490)3.33676309
25interferon-gamma-mediated signaling pathway (GO:0060333)3.33323493
26negative regulation of nitric oxide biosynthetic process (GO:0045019)3.33121220
27regulation of chemokine biosynthetic process (GO:0045073)3.31940221
28granulocyte activation (GO:0036230)3.31167815
29regulation of fever generation (GO:0031620)3.30219825
30regulation of interferon-alpha production (GO:0032647)3.27305689
31virion attachment to host cell (GO:0019062)3.25962152
32adhesion of symbiont to host cell (GO:0044650)3.25962152
33regulation of interferon-beta biosynthetic process (GO:0045357)3.22898925
34type I interferon signaling pathway (GO:0060337)3.22791248
35cellular response to type I interferon (GO:0071357)3.22791248
36response to type I interferon (GO:0034340)3.20486036
37N-acetylneuraminate metabolic process (GO:0006054)3.20265653
38positive regulation of antigen processing and presentation (GO:0002579)3.19487594
39regulation of T-helper 1 cell differentiation (GO:0045625)3.18970503
40cellular response to thyroid hormone stimulus (GO:0097067)3.18927404
41regulation of macrophage chemotaxis (GO:0010758)3.15469133
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.14981083
43negative regulation of cell killing (GO:0031342)3.14981083
44monocyte chemotaxis (GO:0002548)3.14474850
45germinal center formation (GO:0002467)3.14130300
46myeloid dendritic cell differentiation (GO:0043011)3.13888020
47regulation of podosome assembly (GO:0071801)3.13546692
48glycolipid catabolic process (GO:0019377)3.13517441
49regulation of antigen processing and presentation (GO:0002577)3.10626228
50macrophage activation (GO:0042116)3.10332923
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.09409532
52negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.08911043
53low-density lipoprotein particle clearance (GO:0034383)3.08892702
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08278548
55regulation of mast cell degranulation (GO:0043304)3.04072253
56defense response to protozoan (GO:0042832)3.03771998
57regulation of vitamin metabolic process (GO:0030656)3.02592579
58detection of other organism (GO:0098543)3.01243838
59positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00366433
60response to protozoan (GO:0001562)2.99660557
61NIK/NF-kappaB signaling (GO:0038061)2.98385744
62positive regulation of mast cell activation involved in immune response (GO:0033008)2.97197772
63positive regulation of mast cell degranulation (GO:0043306)2.97197772
64regulation of interleukin-8 biosynthetic process (GO:0045414)2.95026102
65detection of external biotic stimulus (GO:0098581)2.94325253
66negative regulation of production of molecular mediator of immune response (GO:0002701)2.93688277
67regulation of heat generation (GO:0031650)2.92684093
68regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90793913
69hydrogen peroxide biosynthetic process (GO:0050665)2.89864643
70regulation of interleukin-12 production (GO:0032655)2.89388290
71neutrophil activation (GO:0042119)2.88132727
72ceramide catabolic process (GO:0046514)2.87002993
73regulation of chronic inflammatory response (GO:0002676)2.86302811
74regulation of cholesterol storage (GO:0010885)2.85304326
75regulation of mast cell activation involved in immune response (GO:0033006)2.84793492
76microglial cell activation (GO:0001774)2.84441584
77positive regulation of mast cell activation (GO:0033005)2.83261710
78myeloid cell activation involved in immune response (GO:0002275)2.83115558
79positive regulation of NF-kappaB import into nucleus (GO:0042346)2.82132349
80myeloid dendritic cell activation (GO:0001773)2.81422763
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80064074
82branching involved in labyrinthine layer morphogenesis (GO:0060670)2.79913034
83detection of bacterium (GO:0016045)2.79880981
84regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78465729
85adhesion of symbiont to host (GO:0044406)2.78269111
86positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76053609
87B cell mediated immunity (GO:0019724)2.75614273
88cellular response to lipopolysaccharide (GO:0071222)2.75141495
89positive regulation of interferon-alpha production (GO:0032727)2.74149558
90regulation of mast cell activation (GO:0033003)2.73125690
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.70926779
92cellular response to molecule of bacterial origin (GO:0071219)2.70609041
93cellular response to interferon-gamma (GO:0071346)2.68823137
94regulation of inflammatory response to antigenic stimulus (GO:0002861)2.67147393
95positive regulation of monocyte chemotaxis (GO:0090026)2.66591317
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.66189799
97regulation of T cell tolerance induction (GO:0002664)2.64778066
98positive regulation of type 2 immune response (GO:0002830)2.64556089
99negative regulation of granulocyte differentiation (GO:0030853)2.64234441
100positive regulation of acute inflammatory response (GO:0002675)2.63933683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.05220592
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.25908937
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.43002200
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.76570436
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.40193624
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38255682
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.20559803
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.11837844
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83774802
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.70527792
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61111587
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57561866
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52492450
14VDR_24787735_ChIP-Seq_THP-1_Human2.38691231
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20237301
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15349654
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12769123
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09367787
19VDR_24763502_ChIP-Seq_THP-1_Human2.07785224
20SPI1_23127762_ChIP-Seq_K562_Human2.04911483
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.00087782
22SPI1_23547873_ChIP-Seq_NB4_Human1.76407579
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75637568
24VDR_21846776_ChIP-Seq_THP-1_Human1.75469323
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71004335
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69850120
27SCL_19346495_ChIP-Seq_HPC-7_Human1.68112505
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67683334
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66452851
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66452128
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66019102
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61820366
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60668329
34CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60094886
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58608665
36RUNX_20019798_ChIP-Seq_JUKART_Human1.53887156
37GATA1_22025678_ChIP-Seq_K562_Human1.49664178
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47476094
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47463850
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47012727
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43414984
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35266860
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32271884
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.30883284
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.29904189
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28522468
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28420336
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.27429827
49LXR_22292898_ChIP-Seq_THP-1_Human1.27181342
50PU_27001747_Chip-Seq_BMDM_Mouse1.26661734
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25785007
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25145771
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.24899941
54GATA1_19941826_ChIP-Seq_K562_Human1.24323623
55STAT1_20625510_ChIP-Seq_HELA_Human1.24091699
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.22895553
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22381598
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22189443
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21055313
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20302726
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20093534
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17039836
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.16819795
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15288769
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14676497
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11833047
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11209658
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.11117790
69MAF_26560356_Chip-Seq_TH1_Human1.09929110
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09847196
71BCL6_27268052_Chip-Seq_Bcells_Human1.08519375
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.04388790
73MYB_26560356_Chip-Seq_TH2_Human1.01368860
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00833308
75GATA3_26560356_Chip-Seq_TH2_Human0.97769970
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.97684490
77BCOR_27268052_Chip-Seq_Bcells_Human0.96165069
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95855639
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92947413
80KDM2B_26808549_Chip-Seq_DND41_Human0.90062030
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87374363
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85586715
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85528369
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84622947
85RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83439968
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82111819
87GATA3_27048872_Chip-Seq_THYMUS_Human0.82041576
88UTX_26944678_Chip-Seq_JUKART_Human0.81276149
89MAF_26560356_Chip-Seq_TH2_Human0.80847861
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80468362
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78794164
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78286400
93TFEB_21752829_ChIP-Seq_HELA_Human0.77425449
94TCF7_22412390_ChIP-Seq_EML_Mouse0.77100686
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76311385
96* ELF1_20517297_ChIP-Seq_JURKAT_Human0.75429119
97MYB_26560356_Chip-Seq_TH1_Human0.75162961
98GATA2_19941826_ChIP-Seq_K562_Human0.74827812
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73786849
100SA1_27219007_Chip-Seq_Bcells_Human0.73590812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.80118658
2MP0005058_abnormal_lysosome_morphology4.02250983
3MP0003724_increased_susceptibility_to3.79283747
4MP0006082_CNS_inflammation3.53208026
5MP0002148_abnormal_hypersensitivity_rea3.23857377
6MP0003436_decreased_susceptibility_to3.21960238
7MP0009785_altered_susceptibility_to3.10612735
8MP0009840_abnormal_foam_cell2.96299348
9MP0002139_abnormal_hepatobiliary_system2.80111540
10MP0001835_abnormal_antigen_presentation2.70473449
11MP0002419_abnormal_innate_immunity2.69480034
12MP0004510_myositis2.60009833
13MP0001790_abnormal_immune_system2.59726665
14MP0005387_immune_system_phenotype2.59726665
15MP0005671_abnormal_response_to2.58808445
16MP0005000_abnormal_immune_tolerance2.49529168
17MP0005025_abnormal_response_to2.46418136
18MP0003172_abnormal_lysosome_physiology2.39431366
19MP0009764_decreased_sensitivity_to2.38621779
20MP0000343_altered_response_to2.30842265
21MP0003300_gastrointestinal_ulcer2.22480471
22MP0003075_altered_response_to2.21839241
23MP0001533_abnormal_skeleton_physiology2.09137671
24MP0002452_abnormal_antigen_presenting2.06402568
25MP0002723_abnormal_immune_serum2.03261507
26MP0001800_abnormal_humoral_immune1.97613904
27MP0005167_abnormal_blood-brain_barrier1.95937914
28MP0000685_abnormal_immune_system1.94211456
29MP0000604_amyloidosis1.93591541
30MP0001845_abnormal_inflammatory_respons1.73957238
31MP0002254_reproductive_system_inflammat1.71934053
32MP0003191_abnormal_cellular_cholesterol1.70530605
33MP0002420_abnormal_adaptive_immunity1.69279396
34MP0001819_abnormal_immune_cell1.69208555
35MP0003690_abnormal_glial_cell1.67593606
36MP0008004_abnormal_stomach_pH1.66684217
37MP0008469_abnormal_protein_level1.66485084
38MP0003806_abnormal_nucleotide_metabolis1.64941079
39MP0002405_respiratory_system_inflammati1.59612446
40MP0002998_abnormal_bone_remodeling1.55315357
41MP0010155_abnormal_intestine_physiology1.54187331
42MP0009278_abnormal_bone_marrow1.53174539
43MP0005310_abnormal_salivary_gland1.48624661
44MP0004947_skin_inflammation1.46329732
45MP0006054_spinal_hemorrhage1.43617628
46MP0005451_abnormal_body_composition1.42464675
47MP0001853_heart_inflammation1.41837500
48MP0003195_calcinosis1.41547465
49MP0005397_hematopoietic_system_phenotyp1.39688928
50MP0001545_abnormal_hematopoietic_system1.39688928
51MP0003448_altered_tumor_morphology1.34016443
52MP0005166_decreased_susceptibility_to1.25395731
53MP0002138_abnormal_hepatobiliary_system1.18374297
54MP0002332_abnormal_exercise_endurance1.18134184
55MP0005365_abnormal_bile_salt1.16358671
56MP0005464_abnormal_platelet_physiology1.16102566
57MP0009333_abnormal_splenocyte_physiolog1.14496231
58MP0000716_abnormal_immune_system1.14453730
59MP0000858_altered_metastatic_potential1.12681978
60MP0003453_abnormal_keratinocyte_physiol1.10149446
61MP0003828_pulmonary_edema1.10032765
62MP0005164_abnormal_response_to1.05276782
63MP0002277_abnormal_respiratory_mucosa1.00211728
64MP0003656_abnormal_erythrocyte_physiolo0.98521311
65MP0001663_abnormal_digestive_system0.95704315
66MP0009763_increased_sensitivity_to0.94449485
67MP0001501_abnormal_sleep_pattern0.94069814
68MP0000920_abnormal_myelination0.92414140
69MP0003646_muscle_fatigue0.92003230
70MP0001542_abnormal_bone_strength0.91729035
71MP0002837_dystrophic_cardiac_calcinosis0.90610671
72MP0005535_abnormal_body_temperature0.87136927
73MP0005390_skeleton_phenotype0.86752363
74MP0000689_abnormal_spleen_morphology0.85172696
75MP0005165_increased_susceptibility_to0.85033422
76MP0003183_abnormal_peptide_metabolism0.84768168
77MP0002933_joint_inflammation0.84160715
78MP0002398_abnormal_bone_marrow0.83022955
79MP0002429_abnormal_blood_cell0.81665774
80MP0004883_abnormal_blood_vessel0.77584203
81MP0003329_amyloid_beta_deposits0.75661578
82MP0005647_abnormal_sex_gland0.74679782
83MP0005595_abnormal_vascular_smooth0.73775525
84MP0000249_abnormal_blood_vessel0.73529005
85MP0003879_abnormal_hair_cell0.70705311
86MP0005666_abnormal_adipose_tissue0.70554546
87MP0009765_abnormal_xenobiotic_induced0.69821757
88MP0002722_abnormal_immune_system0.68849042
89MP0000465_gastrointestinal_hemorrhage0.67683197
90MP0005319_abnormal_enzyme/_coenzyme0.66685271
91MP0008874_decreased_physiological_sensi0.66358162
92MP0000609_abnormal_liver_physiology0.66204085
93MP0003186_abnormal_redox_activity0.65567150
94MP0001764_abnormal_homeostasis0.64660416
95MP0005334_abnormal_fat_pad0.63158499
96MP0009115_abnormal_fat_cell0.63064324
97MP0003795_abnormal_bone_structure0.62661498
98MP0005584_abnormal_enzyme/coenzyme_acti0.61414474
99MP0001873_stomach_inflammation0.60263718
100MP0002118_abnormal_lipid_homeostasis0.60053632

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.34916260
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.34916260
3Abnormality of glycolipid metabolism (HP:0010969)7.34916260
4Systemic lupus erythematosus (HP:0002725)6.24227124
5Vacuolated lymphocytes (HP:0001922)5.32617271
6Increased cerebral lipofuscin (HP:0011813)5.20092472
7Disinhibition (HP:0000734)4.84325907
8Dysostosis multiplex (HP:0000943)4.67379649
9Abnormality of macrophages (HP:0004311)4.66291539
10Mutism (HP:0002300)4.36771385
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.36630107
12Loss of speech (HP:0002371)4.32208711
13Orchitis (HP:0100796)4.18581235
14Glomerulonephritis (HP:0000099)4.14616558
15Recurrent abscess formation (HP:0002722)4.04893717
16Retrobulbar optic neuritis (HP:0100654)4.04063735
17Optic neuritis (HP:0100653)4.04063735
18Recurrent bacterial skin infections (HP:0005406)4.01484985
19Myositis (HP:0100614)3.93154701
20Stomatitis (HP:0010280)3.91593077
21Complement deficiency (HP:0004431)3.90138342
22Eczematoid dermatitis (HP:0000976)3.76491378
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.74095432
24Abnormality of polysaccharide metabolism (HP:0011012)3.74095432
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.74095432
26Recurrent gram-negative bacterial infections (HP:0005420)3.61439774
27Nuclear cataract (HP:0100018)3.44895900
28Mucopolysacchariduria (HP:0008155)3.41448063
29Urinary glycosaminoglycan excretion (HP:0003541)3.41448063
30Autoimmune thrombocytopenia (HP:0001973)3.40467673
31Axonal loss (HP:0003447)3.25161256
32Mediastinal lymphadenopathy (HP:0100721)3.17980820
33Hematochezia (HP:0002573)3.14786056
34Abnormality of complement system (HP:0005339)3.12585107
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.10438905
36Neurofibrillary tangles (HP:0002185)3.00937983
37Inappropriate behavior (HP:0000719)2.95991289
38Spontaneous hematomas (HP:0007420)2.94985028
39Keratoconjunctivitis sicca (HP:0001097)2.94056128
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.91887443
41Purpura (HP:0000979)2.79038441
42Increased serum ferritin (HP:0003281)2.78020433
43Keratoconjunctivitis (HP:0001096)2.76901109
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.75732647
45Amyloidosis (HP:0011034)2.73742234
46Agnosia (HP:0010524)2.68721236
47Pulmonary infiltrates (HP:0002113)2.61766057
48Obstructive lung disease (HP:0006536)2.56953122
49Chronic obstructive pulmonary disease (HP:0006510)2.56953122
50Hemoptysis (HP:0002105)2.54739964
51Diminished motivation (HP:0000745)2.51497713
52Apathy (HP:0000741)2.51420554
53Elevated erythrocyte sedimentation rate (HP:0003565)2.44429142
54Abnormality of iron homeostasis (HP:0011031)2.42143119
55Vasculitis (HP:0002633)2.40273954
56Progressive neurologic deterioration (HP:0002344)2.34344218
57Nephritis (HP:0000123)2.32766247
58Recurrent skin infections (HP:0001581)2.32045368
59Polyneuropathy (HP:0001271)2.30551597
60Neuronal loss in central nervous system (HP:0002529)2.26204108
61Basal ganglia calcification (HP:0002135)2.23849954
62Petechiae (HP:0000967)2.22986533
63Gingivitis (HP:0000230)2.20829199
64Myocardial infarction (HP:0001658)2.19742104
65Gangrene (HP:0100758)2.18282078
66Meningitis (HP:0001287)2.14755418
67Recurrent fungal infections (HP:0002841)2.14515713
68Retinal atrophy (HP:0001105)2.14451411
69Hepatosplenomegaly (HP:0001433)2.10754108
70Nausea (HP:0002018)2.09261332
71Upper motor neuron abnormality (HP:0002127)2.09040547
72Abnormality of transition element cation homeostasis (HP:0011030)2.08014699
73Pulmonary embolism (HP:0002204)2.07544143
74Prolonged neonatal jaundice (HP:0006579)2.06581890
75Dementia (HP:0000726)2.05732311
76Personality changes (HP:0000751)2.04357075
77Asymmetric septal hypertrophy (HP:0001670)2.03460164
78Cerebral inclusion bodies (HP:0100314)2.02290888
79Encephalitis (HP:0002383)2.00721164
80Memory impairment (HP:0002354)1.97703563
81Metaphyseal irregularity (HP:0003025)1.96048437
82Malnutrition (HP:0004395)1.94750655
83Pathologic fracture (HP:0002756)1.92072968
84Peripheral demyelination (HP:0011096)1.91680939
85Global brain atrophy (HP:0002283)1.88518365
86Increased IgM level (HP:0003496)1.88065795
87Urticaria (HP:0001025)1.87863866
88Abnormality of the pleura (HP:0002103)1.87228652
89Conjunctival telangiectasia (HP:0000524)1.84217963
90Vertigo (HP:0002321)1.84124955
91Acne (HP:0001061)1.77647512
92Anorexia (HP:0002039)1.75733525
93Arterial thrombosis (HP:0004420)1.74378995
94Abnormality of the pericardium (HP:0001697)1.73818126
95Increased CSF protein (HP:0002922)1.73607645
96Acrocyanosis (HP:0001063)1.73459199
97Mesangial abnormality (HP:0001966)1.72352553
98Restrictive lung disease (HP:0002091)1.71372235
99Recurrent viral infections (HP:0004429)1.71286738
100Leukocytosis (HP:0001974)1.70879326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.92552608
2BLK3.34462929
3GRK73.09466286
4MAP3K142.75773840
5TGFBR22.70503578
6NME22.69499472
7DDR22.65938258
8RIPK42.56287367
9TBK12.52725551
10ERN12.35989844
11MAP3K112.33530196
12IRAK42.32358578
13MAP4K12.26041381
14TYK22.25417388
15MATK2.24845360
16TAOK12.22580881
17TAOK22.20047965
18ACVR1B2.16337046
19CSK2.05539792
20FGR2.03312310
21IKBKB2.02731882
22TXK1.99560733
23ADRBK21.95088291
24MAP3K31.80440888
25IKBKE1.71536877
26RIPK11.67117371
27MAP2K31.64410023
28CDC42BPA1.48902029
29CAMKK21.42022888
30JAK31.37138496
31ZAP701.32365678
32PIM21.32322900
33ABL21.31726409
34MAP3K131.26989214
35MOS1.26506951
36CSF1R1.26370344
37SYK1.24495809
38PRPF4B1.21123444
39LYN1.21036645
40FES1.13238794
41CHUK1.12172750
42IRAK11.06397974
43DAPK21.04114596
44MAP3K11.03231310
45MARK31.02661410
46TNK21.01938767
47KIT0.97992024
48JAK20.97879793
49MAP2K60.97650368
50CAMK1D0.97309721
51BMPR20.96267196
52IRAK20.93099082
53TAOK30.88561950
54JAK10.85433668
55MAP3K50.83407430
56HCK0.82331159
57LCK0.82081437
58BTK0.76575648
59SIK30.75675087
60TGFBR10.72673840
61SIK20.62589027
62EPHA30.58964500
63PRKAA20.56574239
64MAPK40.51913143
65TYRO30.49685400
66TESK20.47856595
67EPHB20.47367932
68ABL10.46172175
69PIM10.46122180
70MAPK70.44035083
71CDK60.43651478
72PKN10.41041764
73PDPK10.40543567
74RPS6KA60.39751622
75RPS6KC10.39506198
76RPS6KL10.39506198
77EPHB10.39466461
78MARK20.37832626
79DYRK30.37363286
80PDK10.37075777
81ITK0.35230600
82MAPK120.34453824
83PRKG20.34351130
84HIPK20.33981977
85TESK10.32320859
86STK100.30428354
87FRK0.29721070
88TEC0.28551196
89CAMK1G0.28156133
90NEK90.26538206
91FYN0.24410955
92SIK10.24334327
93INSR0.24265904
94PRKD20.23917551
95PRKCD0.22155331
96RPS6KA20.21413342
97PRKACG0.21388760
98MAP3K60.21363146
99PRKCQ0.21313733
100DYRK1B0.21123280

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.66847739
2Other glycan degradation_Homo sapiens_hsa005113.49063037
3Lysosome_Homo sapiens_hsa041422.91498420
4Asthma_Homo sapiens_hsa053102.86667479
5Allograft rejection_Homo sapiens_hsa053302.72300556
6Rheumatoid arthritis_Homo sapiens_hsa053232.66197912
7* Osteoclast differentiation_Homo sapiens_hsa043802.64243843
8Leishmaniasis_Homo sapiens_hsa051402.55651054
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.43365081
10Graft-versus-host disease_Homo sapiens_hsa053322.40971747
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.28368129
12Autoimmune thyroid disease_Homo sapiens_hsa053202.25383183
13Malaria_Homo sapiens_hsa051442.18664921
14Pertussis_Homo sapiens_hsa051332.15782751
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.14375452
16Tuberculosis_Homo sapiens_hsa051522.12840143
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10154893
18NF-kappa B signaling pathway_Homo sapiens_hsa040642.07586283
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06929163
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94008099
21Type I diabetes mellitus_Homo sapiens_hsa049401.85974357
22TNF signaling pathway_Homo sapiens_hsa046681.73372898
23Legionellosis_Homo sapiens_hsa051341.62143768
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59774650
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59708772
26Antigen processing and presentation_Homo sapiens_hsa046121.59504961
27Phagosome_Homo sapiens_hsa041451.59040231
28Complement and coagulation cascades_Homo sapiens_hsa046101.53817316
29Toxoplasmosis_Homo sapiens_hsa051451.45995075
30African trypanosomiasis_Homo sapiens_hsa051431.44105937
31Salmonella infection_Homo sapiens_hsa051321.43201355
32Hematopoietic cell lineage_Homo sapiens_hsa046401.40034073
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33169983
34Influenza A_Homo sapiens_hsa051641.31068727
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29729855
36Prion diseases_Homo sapiens_hsa050201.24044657
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17808299
38Collecting duct acid secretion_Homo sapiens_hsa049661.16387098
39Viral myocarditis_Homo sapiens_hsa054161.15552306
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14804158
41B cell receptor signaling pathway_Homo sapiens_hsa046621.01639042
42Chemokine signaling pathway_Homo sapiens_hsa040621.01507346
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00133388
44Herpes simplex infection_Homo sapiens_hsa051680.96140551
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.93351181
46Measles_Homo sapiens_hsa051620.91166355
47Hepatitis C_Homo sapiens_hsa051600.88161791
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.86538005
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84007100
50Primary immunodeficiency_Homo sapiens_hsa053400.81227195
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80575422
52PPAR signaling pathway_Homo sapiens_hsa033200.77989739
53Sphingolipid metabolism_Homo sapiens_hsa006000.76580540
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76303413
55Mineral absorption_Homo sapiens_hsa049780.75888038
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74532288
57Amoebiasis_Homo sapiens_hsa051460.72017605
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71357117
59Shigellosis_Homo sapiens_hsa051310.65878376
60Tryptophan metabolism_Homo sapiens_hsa003800.65229177
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64253686
62T cell receptor signaling pathway_Homo sapiens_hsa046600.62093468
63Acute myeloid leukemia_Homo sapiens_hsa052210.59798698
64Hepatitis B_Homo sapiens_hsa051610.58995046
65Apoptosis_Homo sapiens_hsa042100.57871103
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55210970
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.50627183
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48078678
69Sulfur metabolism_Homo sapiens_hsa009200.47307988
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45898715
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.44480984
72Prolactin signaling pathway_Homo sapiens_hsa049170.44035840
73Bladder cancer_Homo sapiens_hsa052190.43620175
74Renin-angiotensin system_Homo sapiens_hsa046140.42396031
75Type II diabetes mellitus_Homo sapiens_hsa049300.41303388
76Epstein-Barr virus infection_Homo sapiens_hsa051690.39090924
77Arachidonic acid metabolism_Homo sapiens_hsa005900.38591594
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36546256
79Ether lipid metabolism_Homo sapiens_hsa005650.35307877
80VEGF signaling pathway_Homo sapiens_hsa043700.32686239
81Vibrio cholerae infection_Homo sapiens_hsa051100.32445232
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.26463408
83Platelet activation_Homo sapiens_hsa046110.26190078
84Systemic lupus erythematosus_Homo sapiens_hsa053220.25330940
85Galactose metabolism_Homo sapiens_hsa000520.25024022
86Dorso-ventral axis formation_Homo sapiens_hsa043200.23300398
87Endocytosis_Homo sapiens_hsa041440.22458785
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21889188
89Insulin resistance_Homo sapiens_hsa049310.21251080
90Histidine metabolism_Homo sapiens_hsa003400.21175265
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18193271
92Ovarian steroidogenesis_Homo sapiens_hsa049130.17695570
93HTLV-I infection_Homo sapiens_hsa051660.16076899
94ABC transporters_Homo sapiens_hsa020100.15429528
95Glycerolipid metabolism_Homo sapiens_hsa005610.14955731
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.14045727
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.13823564
98Synaptic vesicle cycle_Homo sapiens_hsa047210.13050079
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12582477
100Chemical carcinogenesis_Homo sapiens_hsa052040.12250371

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