LILRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.16388990
2response to peptidoglycan (GO:0032494)5.96217100
3negative regulation of interleukin-12 production (GO:0032695)5.32175890
4positive regulation by symbiont of host defense response (GO:0052509)5.27909656
5modulation by symbiont of host defense response (GO:0052031)5.27909656
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27909656
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27909656
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.27909656
9modulation by symbiont of host immune response (GO:0052553)5.27909656
10neutrophil activation involved in immune response (GO:0002283)5.00046532
11negative regulation of erythrocyte differentiation (GO:0045647)4.86816727
12macrophage activation involved in immune response (GO:0002281)4.75983441
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.63159088
14detection of molecule of bacterial origin (GO:0032490)4.44119429
15detection of other organism (GO:0098543)4.42757703
16lipopolysaccharide-mediated signaling pathway (GO:0031663)4.36241215
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.32536490
18negative regulation of cell killing (GO:0031342)4.32536490
19cellular extravasation (GO:0045123)4.32355499
20regulation of gamma-delta T cell activation (GO:0046643)4.23783217
21regulation of interferon-beta biosynthetic process (GO:0045357)4.15916108
22immunoglobulin mediated immune response (GO:0016064)4.07742669
23neutrophil mediated immunity (GO:0002446)4.00170696
24detection of bacterium (GO:0016045)3.95475890
25regulation of mast cell degranulation (GO:0043304)3.87989202
26germinal center formation (GO:0002467)3.85960349
27detection of external biotic stimulus (GO:0098581)3.84193386
28regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.81482138
29response to muramyl dipeptide (GO:0032495)3.80840270
30neutrophil activation (GO:0042119)3.72668540
31granulocyte activation (GO:0036230)3.70398030
32macrophage activation (GO:0042116)3.62127674
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.62016462
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58937442
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57936680
36regulation of mast cell activation involved in immune response (GO:0033006)3.57368362
37T-helper 1 type immune response (GO:0042088)3.55654595
38leukocyte aggregation (GO:0070486)3.50991740
39detection of biotic stimulus (GO:0009595)3.50425667
40positive regulation of B cell differentiation (GO:0045579)3.49733280
41positive regulation of mast cell activation (GO:0033005)3.47406674
42regulation of mast cell activation (GO:0033003)3.47299915
43positive regulation of cellular amide metabolic process (GO:0034250)3.46497786
44regulation of B cell receptor signaling pathway (GO:0050855)3.46247432
45regulation of interferon-alpha production (GO:0032647)3.44797348
46JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.42825518
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41418271
48response to host immune response (GO:0052572)3.40595207
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40595207
50positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37705587
51myeloid cell activation involved in immune response (GO:0002275)3.37069001
52cellular response to type I interferon (GO:0071357)3.35823556
53type I interferon signaling pathway (GO:0060337)3.35823556
54respiratory burst (GO:0045730)3.35125477
55defense response to protozoan (GO:0042832)3.34808125
56positive regulation of natural killer cell differentiation (GO:0032825)3.34420776
57positive regulation of interleukin-17 production (GO:0032740)3.33592990
58response to type I interferon (GO:0034340)3.32612046
59response to protozoan (GO:0001562)3.31438463
60negative regulation of T cell mediated immunity (GO:0002710)3.30179275
61positive regulation of interferon-alpha production (GO:0032727)3.29348770
62positive regulation of type 2 immune response (GO:0002830)3.26227122
63microglial cell activation (GO:0001774)3.23891053
64myeloid leukocyte mediated immunity (GO:0002444)3.23589361
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.22809862
66regulation of vitamin D biosynthetic process (GO:0060556)3.20864965
67antigen processing and presentation of endogenous antigen (GO:0019883)3.20782548
68regulation of leukocyte degranulation (GO:0043300)3.19587663
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19003489
70production of molecular mediator involved in inflammatory response (GO:0002532)3.16458128
71regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.16440399
72interferon-gamma-mediated signaling pathway (GO:0060333)3.13878981
73negative regulation of lymphocyte mediated immunity (GO:0002707)3.12571351
74B cell mediated immunity (GO:0019724)3.11865033
75regulation of T-helper 2 cell differentiation (GO:0045628)3.08708906
76response to host (GO:0075136)3.06991275
77response to host defenses (GO:0052200)3.06991275
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06991275
79positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.06882907
80regulation of T cell tolerance induction (GO:0002664)3.04104050
81positive regulation of mast cell degranulation (GO:0043306)3.03699490
82positive regulation of mast cell activation involved in immune response (GO:0033008)3.03699490
83regulation of gamma-delta T cell differentiation (GO:0045586)3.03375530
84regulation of T-helper 1 cell differentiation (GO:0045625)3.02973374
85negative regulation of cytokine production involved in immune response (GO:0002719)3.02824314
86regulation of interleukin-8 biosynthetic process (GO:0045414)3.02527221
87regulation of interleukin-17 production (GO:0032660)2.97592207
88regulation of antigen processing and presentation (GO:0002577)2.96281324
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93737849
90regulation of tolerance induction (GO:0002643)2.92268591
91positive regulation of antigen processing and presentation (GO:0002579)2.92046022
92regulation of interleukin-12 production (GO:0032655)2.88590248
93positive regulation of interferon-beta production (GO:0032728)2.88375466
94leukocyte migration involved in inflammatory response (GO:0002523)2.83908889
95negative regulation of interleukin-6 production (GO:0032715)2.83659984
96leukocyte degranulation (GO:0043299)2.83105252
97cellular response to thyroid hormone stimulus (GO:0097067)2.82726911
98interferon-gamma secretion (GO:0072643)2.82316835
99positive regulation of NF-kappaB import into nucleus (GO:0042346)2.81709263
100negative regulation of leukocyte mediated immunity (GO:0002704)2.79733394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.43692460
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.04802361
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.33421639
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.10902018
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49198517
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.22253313
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12753481
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.06101001
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96013103
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92633024
11SPI1_23127762_ChIP-Seq_K562_Human2.84420945
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.81004292
13VDR_21846776_ChIP-Seq_THP-1_Human2.79444615
14SPI1_23547873_ChIP-Seq_NB4_Human2.69715863
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66674480
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61707691
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58689118
18SCL_19346495_ChIP-Seq_HPC-7_Human2.58070169
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54542254
20VDR_24763502_ChIP-Seq_THP-1_Human2.53070879
21GATA1_22025678_ChIP-Seq_K562_Human2.50278741
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42596820
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31598404
24GATA1_19941826_ChIP-Seq_K562_Human2.29078073
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27599010
26MAF_26560356_Chip-Seq_TH1_Human2.26287872
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12355448
28MYC_22102868_ChIP-Seq_BL_Human2.11547269
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10356290
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.04384888
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97263245
32MYB_26560356_Chip-Seq_TH2_Human1.96390320
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91675980
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87494611
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83934566
36NCOR1_26117541_ChIP-Seq_K562_Human1.82778135
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82614751
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.80866182
39UTX_26944678_Chip-Seq_JUKART_Human1.78737332
40MYB_26560356_Chip-Seq_TH1_Human1.77547803
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76975145
42RUNX_20019798_ChIP-Seq_JUKART_Human1.76782290
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74869828
44VDR_24787735_ChIP-Seq_THP-1_Human1.67325566
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61696773
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.58325200
47MAF_26560356_Chip-Seq_TH2_Human1.56974063
48GATA2_19941826_ChIP-Seq_K562_Human1.56689281
49TCF7_22412390_ChIP-Seq_EML_Mouse1.56595117
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54040758
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50945676
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49722769
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.48831271
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41351025
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39690419
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38412004
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38149506
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37777447
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35079262
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34858685
61KDM2B_26808549_Chip-Seq_DND41_Human1.34677114
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32371842
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30346306
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29184328
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28994967
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27382080
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25162295
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24324058
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22480605
70PU_27001747_Chip-Seq_BMDM_Mouse1.21812221
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21203910
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20900574
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19595916
74LXR_22292898_ChIP-Seq_THP-1_Human1.18967033
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18052193
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17065916
77GATA3_27048872_Chip-Seq_THYMUS_Human1.16837841
78TFEB_21752829_ChIP-Seq_HELA_Human1.14239240
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09732969
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07131060
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07126642
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.06839075
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06069924
84GATA3_26560356_Chip-Seq_TH2_Human1.03317239
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02304537
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00322639
87BCOR_27268052_Chip-Seq_Bcells_Human0.99063733
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97463958
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97228480
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96954725
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96547373
92BCL6_27268052_Chip-Seq_Bcells_Human0.95251512
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93761067
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.92931863
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92199628
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.91892450
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91808792
98EGR1_19032775_ChIP-ChIP_M12_Human0.91748112
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91494732
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90225337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.18911867
2MP0003724_increased_susceptibility_to4.57900699
3MP0003436_decreased_susceptibility_to3.79516887
4MP0001835_abnormal_antigen_presentation3.37067379
5MP0009785_altered_susceptibility_to3.12286177
6MP0002419_abnormal_innate_immunity2.98994809
7MP0006082_CNS_inflammation2.94828757
8MP0002148_abnormal_hypersensitivity_rea2.91727056
9MP0005025_abnormal_response_to2.78102985
10MP0005000_abnormal_immune_tolerance2.70017864
11MP0005387_immune_system_phenotype2.65477962
12MP0001790_abnormal_immune_system2.65477962
13MP0005451_abnormal_body_composition2.61409731
14MP0005671_abnormal_response_to2.58776530
15MP0009278_abnormal_bone_marrow2.58449684
16MP0001800_abnormal_humoral_immune2.40241953
17MP0002723_abnormal_immune_serum2.37354789
18MP0005397_hematopoietic_system_phenotyp2.36206719
19MP0001545_abnormal_hematopoietic_system2.36206719
20MP0002452_abnormal_antigen_presenting2.34062051
21MP0003300_gastrointestinal_ulcer2.32683886
22MP0003656_abnormal_erythrocyte_physiolo2.27841163
23MP0000685_abnormal_immune_system2.14280786
24MP0001819_abnormal_immune_cell2.14074512
25MP0002420_abnormal_adaptive_immunity2.13681533
26MP0009764_decreased_sensitivity_to2.03234220
27MP0002132_abnormal_respiratory_system1.98805423
28MP0001533_abnormal_skeleton_physiology1.92938464
29MP0005058_abnormal_lysosome_morphology1.92791896
30MP0004947_skin_inflammation1.92204172
31MP0002405_respiratory_system_inflammati1.87124332
32MP0005464_abnormal_platelet_physiology1.80665593
33MP0003172_abnormal_lysosome_physiology1.77391932
34MP0001845_abnormal_inflammatory_respons1.76427677
35MP0010155_abnormal_intestine_physiology1.70960005
36MP0004510_myositis1.70817876
37MP0002398_abnormal_bone_marrow1.67347600
38MP0003075_altered_response_to1.62689020
39MP0008469_abnormal_protein_level1.60767396
40MP0000343_altered_response_to1.60407018
41MP0000716_abnormal_immune_system1.60390592
42MP0008004_abnormal_stomach_pH1.55203739
43MP0009333_abnormal_splenocyte_physiolog1.55177821
44MP0003806_abnormal_nucleotide_metabolis1.49413787
45MP0003191_abnormal_cellular_cholesterol1.48756292
46MP0002722_abnormal_immune_system1.48103733
47MP0000689_abnormal_spleen_morphology1.42031848
48MP0002429_abnormal_blood_cell1.37526966
49MP0001853_heart_inflammation1.37402557
50MP0008260_abnormal_autophagy1.31812367
51MP0003828_pulmonary_edema1.29280138
52MP0002396_abnormal_hematopoietic_system1.24557197
53MP0009840_abnormal_foam_cell1.17481117
54MP0005166_decreased_susceptibility_to1.16539845
55MP0003690_abnormal_glial_cell1.16493104
56MP0005167_abnormal_blood-brain_barrier1.16400012
57MP0000858_altered_metastatic_potential1.14734223
58MP0002998_abnormal_bone_remodeling1.13623478
59MP0000465_gastrointestinal_hemorrhage1.12101784
60MP0001873_stomach_inflammation1.11478468
61MP0005310_abnormal_salivary_gland1.09896193
62MP0002332_abnormal_exercise_endurance1.09019020
63MP0003763_abnormal_thymus_physiology1.07811998
64MP0003448_altered_tumor_morphology1.07673454
65MP0004808_abnormal_hematopoietic_stem1.01509703
66MP0000703_abnormal_thymus_morphology1.00375150
67MP0009763_increased_sensitivity_to1.00355018
68MP0005164_abnormal_response_to0.98042825
69MP0003221_abnormal_cardiomyocyte_apopto0.94829672
70MP0004883_abnormal_blood_vessel0.93187514
71MP0002277_abnormal_respiratory_mucosa0.91493091
72MP0002139_abnormal_hepatobiliary_system0.89683352
73MP0000604_amyloidosis0.86558590
74MP0009765_abnormal_xenobiotic_induced0.84618410
75MP0001663_abnormal_digestive_system0.80825090
76MP0005076_abnormal_cell_differentiation0.80214186
77MP0005535_abnormal_body_temperature0.75307012
78MP0003453_abnormal_keratinocyte_physiol0.71590297
79MP0003646_muscle_fatigue0.70454677
80MP0005390_skeleton_phenotype0.70411853
81MP0000678_abnormal_parathyroid_gland0.70118401
82MP0001851_eye_inflammation0.69973520
83MP0000609_abnormal_liver_physiology0.69608834
84MP0002138_abnormal_hepatobiliary_system0.67278653
85MP0004147_increased_porphyrin_level0.66987026
86MP0006054_spinal_hemorrhage0.64894029
87MP0003183_abnormal_peptide_metabolism0.60369787
88MP0003045_fibrosis0.59997576
89MP0010307_abnormal_tumor_latency0.59615533
90MP0005319_abnormal_enzyme/_coenzyme0.58775136
91MP0005083_abnormal_biliary_tract0.58520353
92MP0003795_abnormal_bone_structure0.55845138
93MP0002877_abnormal_melanocyte_morpholog0.55355700
94MP0003866_abnormal_defecation0.55341782
95MP0008874_decreased_physiological_sensi0.53900819
96MP0000920_abnormal_myelination0.53762874
97MP0009115_abnormal_fat_cell0.52324323
98MP0000490_abnormal_crypts_of0.52096036
99MP0002019_abnormal_tumor_incidence0.51483284
100MP0002254_reproductive_system_inflammat0.51305260

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.70114783
2Retrobulbar optic neuritis (HP:0100654)5.61847090
3Optic neuritis (HP:0100653)5.61847090
4Myositis (HP:0100614)5.49005429
5Abnormality of macrophages (HP:0004311)5.48611612
6Eczematoid dermatitis (HP:0000976)5.46293241
7Recurrent bacterial skin infections (HP:0005406)5.32485765
8Recurrent abscess formation (HP:0002722)5.24882051
9Stomatitis (HP:0010280)4.75780385
10Keratoconjunctivitis sicca (HP:0001097)4.19637137
11Elevated erythrocyte sedimentation rate (HP:0003565)3.98865690
12Recurrent gram-negative bacterial infections (HP:0005420)3.94119649
13Chronic obstructive pulmonary disease (HP:0006510)3.87372655
14Obstructive lung disease (HP:0006536)3.87372655
15Keratoconjunctivitis (HP:0001096)3.82058559
16Mediastinal lymphadenopathy (HP:0100721)3.71450513
17Abnormality of glycolipid metabolism (HP:0010969)3.64464635
18Abnormality of liposaccharide metabolism (HP:0010968)3.64464635
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.64464635
20Polycythemia (HP:0001901)3.53541268
21Gastrointestinal infarctions (HP:0005244)3.47290245
22Recurrent fungal infections (HP:0002841)3.42150117
23Encephalitis (HP:0002383)3.36410367
24Increased cerebral lipofuscin (HP:0011813)3.34773784
25Abnormal gallbladder physiology (HP:0012438)3.28407402
26Cholecystitis (HP:0001082)3.28407402
27Recurrent skin infections (HP:0001581)3.28380751
28Episodic fever (HP:0001954)3.20494542
29Increased serum ferritin (HP:0003281)3.19150765
30Meningitis (HP:0001287)3.15293176
31Arterial thrombosis (HP:0004420)3.14099659
32Amyloidosis (HP:0011034)3.09714014
33Urticaria (HP:0001025)3.08048467
34Vasculitis (HP:0002633)3.06830514
35Hemoptysis (HP:0002105)3.03487001
36Spontaneous hematomas (HP:0007420)2.97503074
37Increased IgE level (HP:0003212)2.87253486
38Pulmonary infiltrates (HP:0002113)2.83740519
39Anorexia (HP:0002039)2.82558054
40Abnormality of iron homeostasis (HP:0011031)2.81444242
41Prolonged bleeding time (HP:0003010)2.81244248
42Gangrene (HP:0100758)2.80428428
43Autoimmune thrombocytopenia (HP:0001973)2.78387609
44Loss of speech (HP:0002371)2.77889372
45Chronic mucocutaneous candidiasis (HP:0002728)2.75676033
46Recurrent cutaneous fungal infections (HP:0011370)2.75676033
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.75008342
48Recurrent viral infections (HP:0004429)2.74329346
49Petechiae (HP:0000967)2.72866422
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.69453381
51Abnormality of the heme biosynthetic pathway (HP:0010472)2.68012936
52Reticulocytosis (HP:0001923)2.67635966
53Vacuolated lymphocytes (HP:0001922)2.66114068
54Hypertensive crisis (HP:0100735)2.60721737
55Leukocytosis (HP:0001974)2.58803686
56Gingivitis (HP:0000230)2.57471183
57Granulocytopenia (HP:0001913)2.57097824
58Increased IgM level (HP:0003496)2.52626990
59Dysostosis multiplex (HP:0000943)2.52028564
60Abnormality of transition element cation homeostasis (HP:0011030)2.41776994
61Pulmonary embolism (HP:0002204)2.41191016
62Chest pain (HP:0100749)2.41152235
63Vertigo (HP:0002321)2.37509526
64Cellulitis (HP:0100658)2.36281995
65Disinhibition (HP:0000734)2.34497954
66Polyneuropathy (HP:0001271)2.29515185
67Abnormality of the pleura (HP:0002103)2.29460064
68Keratitis (HP:0000491)2.28867018
69Epistaxis (HP:0000421)2.26741505
70Acne (HP:0001061)2.26249417
71Hepatosplenomegaly (HP:0001433)2.22230315
72Autoimmune hemolytic anemia (HP:0001890)2.15168824
73Peritonitis (HP:0002586)2.12944465
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12595423
75Ventricular fibrillation (HP:0001663)2.11537343
76Osteomyelitis (HP:0002754)2.08136229
77Colitis (HP:0002583)2.08081116
78Inflammation of the large intestine (HP:0002037)2.04842770
79Hematochezia (HP:0002573)2.03657281
80Abnormality of the endocardium (HP:0004306)2.03583594
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02956751
82Abnormality of the peritoneum (HP:0002585)2.02222795
83Gastrointestinal inflammation (HP:0004386)2.00625764
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96888560
85Amaurosis fugax (HP:0100576)1.96566009
86Thoracic kyphosis (HP:0002942)1.94020264
87Hypergammaglobulinemia (HP:0010702)1.94012963
88Skin rash (HP:0000988)1.93857440
89Abnormality of polysaccharide metabolism (HP:0011012)1.92748289
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92748289
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92748289
92Sepsis (HP:0100806)1.92287002
93Thrombophlebitis (HP:0004418)1.92181982
94Segmental peripheral demyelination/remyelination (HP:0003481)1.91862673
95Glomerulopathy (HP:0100820)1.91689792
96Myocardial infarction (HP:0001658)1.90159450
97Abnormality of T cells (HP:0002843)1.89425921
98Slow saccadic eye movements (HP:0000514)1.88486722
99T lymphocytopenia (HP:0005403)1.88251355
100Gingival bleeding (HP:0000225)1.87978892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.02896052
2IRAK33.37444244
3IRAK42.97193157
4BLK2.91964834
5MAP3K142.69535926
6PRPF4B2.62625407
7TYK22.58572859
8MATK2.49952693
9MAP2K32.47460086
10BMPR22.45346050
11MAP4K12.44565756
12ERN12.38274943
13CSK2.25488448
14KSR22.16247318
15JAK32.09773659
16TAOK21.95039495
17ZAP701.82515201
18FGR1.78362482
19JAK21.75545478
20TXK1.74384580
21TBK11.73135713
22GRK71.71789579
23CLK11.68783147
24BTK1.58473019
25TAOK11.57677025
26FES1.49371090
27MAP3K11.45854299
28IRAK11.45289246
29HCK1.41978517
30SYK1.39989460
31IKBKE1.39021465
32STK101.38771369
33MAP3K131.36252101
34IKBKB1.30561434
35MAP3K31.28922161
36EPHB11.27978948
37MAP3K111.26835508
38LYN1.25816689
39IRAK21.25526757
40RAF11.20055131
41TNK21.14241544
42MARK31.08600637
43NME21.05412178
44JAK11.03294120
45MOS1.00869558
46TAOK30.98419737
47SIK30.97425160
48KSR10.92966714
49TEC0.90442455
50MAP3K20.89832109
51GRK60.89501344
52LCK0.85887487
53DYRK30.82580257
54MAP3K80.81588726
55YES10.78598547
56TESK20.76522180
57CDC42BPA0.75709673
58KIT0.72863285
59EPHA30.72135106
60PIM10.66177699
61MAP3K50.65362439
62ITK0.62290963
63TGFBR20.58501667
64RIPK10.58000081
65PDPK10.56333948
66PDK10.56224699
67PIM20.54592511
68DDR20.54151886
69MARK20.53746421
70PTK60.52554713
71MAP3K60.52294819
72CSF1R0.51569277
73ALK0.48792678
74TRIB30.48678444
75PRKG20.47485884
76HIPK20.47036699
77ICK0.46317251
78BMX0.45055743
79CDK120.38713555
80SIK20.38153801
81DAPK20.36607863
82SMG10.35526820
83MAP2K60.34040523
84BUB10.31393995
85FYN0.31120818
86LRRK20.30734029
87PAK10.29460402
88MAPK120.29425412
89MAPKAPK20.28484380
90ADRBK20.28402149
91RET0.27425211
92TRPM70.27416668
93CHUK0.27044621
94PRKD20.25601921
95MAP3K70.25542419
96MAPK40.23809703
97PRKAA20.23739072
98PIK3CG0.23714880
99RPS6KL10.22110565
100RPS6KC10.22110565

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.41577375
2Leishmaniasis_Homo sapiens_hsa051403.15267937
3Osteoclast differentiation_Homo sapiens_hsa043803.12766341
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73262166
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.70743296
6Staphylococcus aureus infection_Homo sapiens_hsa051502.61113912
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.32061193
8Tuberculosis_Homo sapiens_hsa051522.22490519
9Legionellosis_Homo sapiens_hsa051342.20750950
10Malaria_Homo sapiens_hsa051442.19535636
11Graft-versus-host disease_Homo sapiens_hsa053322.10552447
12Allograft rejection_Homo sapiens_hsa053302.09082945
13B cell receptor signaling pathway_Homo sapiens_hsa046622.00389774
14Other glycan degradation_Homo sapiens_hsa005111.93937338
15TNF signaling pathway_Homo sapiens_hsa046681.91178446
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87982680
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86147077
18Influenza A_Homo sapiens_hsa051641.84931228
19Acute myeloid leukemia_Homo sapiens_hsa052211.82755401
20Rheumatoid arthritis_Homo sapiens_hsa053231.78117026
21African trypanosomiasis_Homo sapiens_hsa051431.75973130
22Measles_Homo sapiens_hsa051621.75066963
23Autoimmune thyroid disease_Homo sapiens_hsa053201.71140451
24Pertussis_Homo sapiens_hsa051331.63928356
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61393602
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61243220
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.58040648
28Toxoplasmosis_Homo sapiens_hsa051451.57572374
29Asthma_Homo sapiens_hsa053101.53754119
30Hematopoietic cell lineage_Homo sapiens_hsa046401.50720106
31Herpes simplex infection_Homo sapiens_hsa051681.50063026
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47962225
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47115259
34Chemokine signaling pathway_Homo sapiens_hsa040621.45046038
35Type I diabetes mellitus_Homo sapiens_hsa049401.44763691
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.44753356
37Hepatitis B_Homo sapiens_hsa051611.37846201
38Salmonella infection_Homo sapiens_hsa051321.36836428
39Antigen processing and presentation_Homo sapiens_hsa046121.35969649
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34748207
41Shigellosis_Homo sapiens_hsa051311.32044425
42Phagosome_Homo sapiens_hsa041451.25738374
43Lysosome_Homo sapiens_hsa041421.25166449
44Hepatitis C_Homo sapiens_hsa051601.12510304
45Viral myocarditis_Homo sapiens_hsa054161.12397954
46Primary immunodeficiency_Homo sapiens_hsa053401.09209965
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.08450334
48T cell receptor signaling pathway_Homo sapiens_hsa046601.07769502
49Chronic myeloid leukemia_Homo sapiens_hsa052201.04386650
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03469318
51Type II diabetes mellitus_Homo sapiens_hsa049301.03327566
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99350300
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99034939
54VEGF signaling pathway_Homo sapiens_hsa043700.98639833
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96526445
56Prolactin signaling pathway_Homo sapiens_hsa049170.95242629
57Apoptosis_Homo sapiens_hsa042100.94606328
58Pancreatic cancer_Homo sapiens_hsa052120.87381381
59Epstein-Barr virus infection_Homo sapiens_hsa051690.86205640
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.83544074
61Bladder cancer_Homo sapiens_hsa052190.78561029
62HIF-1 signaling pathway_Homo sapiens_hsa040660.77963659
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75991605
64Non-small cell lung cancer_Homo sapiens_hsa052230.73656625
65Viral carcinogenesis_Homo sapiens_hsa052030.70770754
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69088893
67Amoebiasis_Homo sapiens_hsa051460.68859439
68Renal cell carcinoma_Homo sapiens_hsa052110.68070928
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67883465
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.63477562
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.62944554
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61928788
73Prion diseases_Homo sapiens_hsa050200.61664563
74Platelet activation_Homo sapiens_hsa046110.61296506
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58520703
76Dorso-ventral axis formation_Homo sapiens_hsa043200.53712769
77mTOR signaling pathway_Homo sapiens_hsa041500.48541783
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48363269
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.47761370
80HTLV-I infection_Homo sapiens_hsa051660.47740542
81ErbB signaling pathway_Homo sapiens_hsa040120.38792581
82FoxO signaling pathway_Homo sapiens_hsa040680.36874840
83GnRH signaling pathway_Homo sapiens_hsa049120.36114976
84Insulin resistance_Homo sapiens_hsa049310.35415184
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.33684022
86Endocytosis_Homo sapiens_hsa041440.32717145
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31137240
88Insulin signaling pathway_Homo sapiens_hsa049100.31059264
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29557634
90Fructose and mannose metabolism_Homo sapiens_hsa000510.27325527
91Choline metabolism in cancer_Homo sapiens_hsa052310.26740667
92Notch signaling pathway_Homo sapiens_hsa043300.26703337
93MAPK signaling pathway_Homo sapiens_hsa040100.26187906
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25663893
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24858035
96Pentose phosphate pathway_Homo sapiens_hsa000300.23145577
97Collecting duct acid secretion_Homo sapiens_hsa049660.22617363
98Endometrial cancer_Homo sapiens_hsa052130.21473292
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21237463
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19695103

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