LIMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.27226799
2chondrocyte proliferation (GO:0035988)4.25178391
3collagen fibril organization (GO:0030199)3.97395761
4skin morphogenesis (GO:0043589)3.83140687
5regulation of transforming growth factor beta2 production (GO:0032909)3.79868075
6endodermal cell differentiation (GO:0035987)3.78826877
7cell adhesion mediated by integrin (GO:0033627)3.77423951
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.70281307
9endocardial cushion development (GO:0003197)3.62903793
10protein heterotrimerization (GO:0070208)3.59519963
11bone trabecula formation (GO:0060346)3.51503356
12keratinocyte proliferation (GO:0043616)3.50648178
13epithelial cell-cell adhesion (GO:0090136)3.50410427
14COPI coating of Golgi vesicle (GO:0048205)3.45997228
15Golgi transport vesicle coating (GO:0048200)3.45997228
16cell migration involved in heart development (GO:0060973)3.41934479
17regulation of keratinocyte proliferation (GO:0010837)3.38006621
18hippo signaling (GO:0035329)3.34028880
19apoptotic cell clearance (GO:0043277)3.33871000
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.29508571
21basement membrane organization (GO:0071711)3.29468347
22bundle of His cell to Purkinje myocyte communication (GO:0086069)3.29248690
23positive regulation of endothelial cell apoptotic process (GO:2000353)3.24364563
24hypotonic response (GO:0006971)3.21810969
25negative regulation of chondrocyte differentiation (GO:0032331)3.18285491
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15974648
27endothelial cell morphogenesis (GO:0001886)3.13132605
28membrane raft organization (GO:0031579)3.12731903
29type B pancreatic cell proliferation (GO:0044342)3.12603397
30regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.11137068
31COPII vesicle coating (GO:0048208)3.08293545
32protein retention in ER lumen (GO:0006621)3.07500167
33actin filament depolymerization (GO:0030042)3.06842273
34extracellular fibril organization (GO:0043206)3.04929411
35kidney mesenchyme development (GO:0072074)3.04144292
36smooth muscle tissue development (GO:0048745)3.02778824
37virion attachment to host cell (GO:0019062)3.02232843
38adhesion of symbiont to host cell (GO:0044650)3.02232843
39wound healing, spreading of epidermal cells (GO:0035313)3.01682393
40desmosome organization (GO:0002934)2.99955302
41epoxygenase P450 pathway (GO:0019373)2.98111669
42gap junction assembly (GO:0016264)2.97339737
43barbed-end actin filament capping (GO:0051016)2.96415028
44cellular response to vitamin (GO:0071295)2.95134624
45paraxial mesoderm development (GO:0048339)2.93856152
46cellular response to vitamin D (GO:0071305)2.93234994
47planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92420782
48regulation of transforming growth factor beta1 production (GO:0032908)2.90901582
49polarized epithelial cell differentiation (GO:0030859)2.90589228
50cell-substrate adherens junction assembly (GO:0007045)2.88953409
51focal adhesion assembly (GO:0048041)2.88953409
52retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86320842
53negative regulation of stem cell proliferation (GO:2000647)2.85054706
54positive regulation of p38MAPK cascade (GO:1900745)2.84491025
55craniofacial suture morphogenesis (GO:0097094)2.83994567
56G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.82603880
57mesodermal cell differentiation (GO:0048333)2.82332605
58negative regulation of fatty acid transport (GO:2000192)2.81733821
59collagen metabolic process (GO:0032963)2.81163990
60axon extension involved in axon guidance (GO:0048846)2.79053981
61neuron projection extension involved in neuron projection guidance (GO:1902284)2.79053981
62cranial suture morphogenesis (GO:0060363)2.78647340
63fibril organization (GO:0097435)2.76945202
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75902001
65renal filtration (GO:0097205)2.75826916
66cell-substrate junction assembly (GO:0007044)2.75305410
67regulation of hippo signaling (GO:0035330)2.75148237
68multicellular organismal macromolecule metabolic process (GO:0044259)2.74940272
69notochord development (GO:0030903)2.73511898
70regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72933685
71adherens junction assembly (GO:0034333)2.72342767
72mesenchymal-epithelial cell signaling (GO:0060638)2.72265053
73extracellular matrix disassembly (GO:0022617)2.70862206
74multicellular organismal catabolic process (GO:0044243)2.69901993
75substrate-dependent cell migration (GO:0006929)2.69845213
76cell junction assembly (GO:0034329)2.69776926
77cell migration involved in sprouting angiogenesis (GO:0002042)2.69660788
78muscle cell migration (GO:0014812)2.68657981
79multicellular organismal metabolic process (GO:0044236)2.68649451
80collagen catabolic process (GO:0030574)2.68559754
81adhesion of symbiont to host (GO:0044406)2.68392450
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.68207680
83intestinal absorption (GO:0050892)2.67330517
84protein localization to endosome (GO:0036010)2.66920343
85regulation of SMAD protein import into nucleus (GO:0060390)2.66575245
86regulation of water loss via skin (GO:0033561)2.66363737
87intestinal cholesterol absorption (GO:0030299)2.64095283
88substrate adhesion-dependent cell spreading (GO:0034446)2.63760772
89extracellular matrix organization (GO:0030198)2.63501071
90sulfur amino acid catabolic process (GO:0000098)2.63274864
91extracellular structure organization (GO:0043062)2.62682516
92glomerular basement membrane development (GO:0032836)2.62260092
93nucleotide-sugar biosynthetic process (GO:0009226)2.62092491
94regulation of integrin-mediated signaling pathway (GO:2001044)2.58386125
95positive regulation of SMAD protein import into nucleus (GO:0060391)2.58230031
96regulation of metalloenzyme activity (GO:0048552)2.58152778
97positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57535225
98outer ear morphogenesis (GO:0042473)2.55966992
99negative regulation of anoikis (GO:2000811)2.55899076
100hormone catabolic process (GO:0042447)2.55509696
101negative regulation of cartilage development (GO:0061037)2.55068299
102sequestering of extracellular ligand from receptor (GO:0035581)2.53697582
103vitamin A metabolic process (GO:0006776)2.53355282
104glomerular visceral epithelial cell development (GO:0072015)2.52743872
105atrioventricular valve morphogenesis (GO:0003181)2.51278562
106wound healing, spreading of cells (GO:0044319)2.51274086
107regulation of heart morphogenesis (GO:2000826)2.49529231
108establishment of skin barrier (GO:0061436)2.48602733
109regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.48081584
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47960670
111cell junction organization (GO:0034330)2.47692208
112anterior/posterior axis specification, embryo (GO:0008595)2.47501748
113positive regulation of actin filament depolymerization (GO:0030836)2.47103184
114embryonic cranial skeleton morphogenesis (GO:0048701)2.47091601
115negative regulation of protein localization to plasma membrane (GO:1903077)2.44181849
116regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.43992426
117cell-matrix adhesion (GO:0007160)2.43266862
118blood vessel endothelial cell migration (GO:0043534)2.41183635
119midgut development (GO:0007494)2.40230441
120protein localization to cell surface (GO:0034394)2.39392343
121tight junction assembly (GO:0070830)2.37403176
122positive regulation of mesenchymal cell proliferation (GO:0002053)2.36852263
123negative regulation of smooth muscle cell migration (GO:0014912)2.36617555
124positive regulation of osteoblast proliferation (GO:0033690)2.36335245
125extracellular matrix assembly (GO:0085029)2.36265009
126negative regulation of catenin import into nucleus (GO:0035414)2.35983329
127branching involved in prostate gland morphogenesis (GO:0060442)2.35652980
128vascular endothelial growth factor signaling pathway (GO:0038084)2.34624259
129negative regulation of keratinocyte proliferation (GO:0010839)2.33834036
130regulation of integrin activation (GO:0033623)2.33313211
131cellular response to interferon-alpha (GO:0035457)2.33279950
132middle ear morphogenesis (GO:0042474)2.33099907
133intestinal epithelial cell development (GO:0060576)2.33083639
134bone morphogenesis (GO:0060349)2.32612372
135negative regulation of fibrinolysis (GO:0051918)2.32217978
136metanephric mesenchyme development (GO:0072075)2.30666105
137positive regulation of extracellular matrix organization (GO:1903055)2.30326338
138embryonic camera-type eye development (GO:0031076)2.30196503
139positive regulation of epithelial to mesenchymal transition (GO:0010718)2.29626318
140prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.28656225
141wound healing (GO:0042060)2.27931524
142regulation of tight junction assembly (GO:2000810)2.27679336
143establishment of apical/basal cell polarity (GO:0035089)2.27450279
144regulation of cholesterol homeostasis (GO:2000188)2.27429455
145glomerular filtration (GO:0003094)2.27302962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.29073508
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.80950712
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.70238943
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.38721511
5CLOCK_20551151_ChIP-Seq_293T_Human2.86618645
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.76305828
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.58455012
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47333545
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46138498
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.44073473
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.18246839
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.14861452
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.13966551
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.10110333
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09238122
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06064853
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06064853
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06064853
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05778124
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04371044
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03046046
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99364111
23* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.97463938
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96987101
25TP53_18474530_ChIP-ChIP_U2OS_Human1.96575363
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.94531385
27CJUN_26792858_Chip-Seq_BT549_Human1.90049533
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.88655305
29* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88138325
30* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88138325
31* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.84878469
32* SOX2_20726797_ChIP-Seq_SW620_Human1.83795251
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.83243186
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80664304
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80014025
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79160966
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.77268014
38* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76313998
39* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69291447
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68504215
41* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67080449
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.66779627
43* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66474519
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65381605
45* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65369909
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62215186
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60628434
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58661781
49* GATA4_25053715_ChIP-Seq_YYC3_Human1.57644808
50* GATA2_21666600_ChIP-Seq_HMVEC_Human1.57471493
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55035479
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54549433
53BRD4_25478319_ChIP-Seq_HGPS_Human1.53970855
54* TP63_23658742_ChIP-Seq_EP156T_Human1.51474454
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.49756938
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46381318
57GATA6_25053715_ChIP-Seq_YYC3_Human1.42923416
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40669689
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40669689
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40184190
61RACK7_27058665_Chip-Seq_MCF-7_Human1.38076142
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37937431
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37419739
64AR_21909140_ChIP-Seq_LNCAP_Human1.35866044
65ATF3_27146783_Chip-Seq_COLON_Human1.33265673
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31203827
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28706891
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.27265285
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26575354
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26048059
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24737908
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.23622811
73* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23333600
74* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.22637584
75ZNF263_19887448_ChIP-Seq_K562_Human1.22515846
76* AHR_22903824_ChIP-Seq_MCF-7_Human1.22450626
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.21964644
78* TBX20_22328084_ChIP-Seq_HEART_Mouse1.21570794
79* TBX20_22080862_ChIP-Seq_HEART_Mouse1.21570794
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21360300
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.21343104
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20909932
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19950439
84* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19367296
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18845564
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18203224
87EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17853676
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17530669
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17434601
90KLF5_25053715_ChIP-Seq_YYC3_Human1.16353655
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14438492
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13402032
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11939932
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10711462
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.10579337
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09399626
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08708772
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07630734
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07031895
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04674636
101TP53_16413492_ChIP-PET_HCT116_Human1.03855775
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.01655414
103GATA3_24758297_ChIP-Seq_MCF-7_Human1.01649128
104SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01354103
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00454066
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.98603203
107NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98228782
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97954350
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97587653
110* ARNT_22903824_ChIP-Seq_MCF-7_Human0.97007905
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.96894838
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96548836
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95847284
114* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95598725
115* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95332814
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94974783
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94860828
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94361618
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.93010899
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92910127
121CDX2_22108803_ChIP-Seq_LS180_Human0.91998150
122* TP53_22127205_ChIP-Seq_IMR90_Human0.89970296
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86884957
124SA1_22415368_ChIP-Seq_MEFs_Mouse0.83731017
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83523826
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80719104
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76943334
128* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76080583
129* TP53_23651856_ChIP-Seq_MEFs_Mouse0.73605522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.42174078
2MP0003705_abnormal_hypodermis_morpholog4.17121797
3MP0005275_abnormal_skin_tensile3.98676581
4MP0005503_abnormal_tendon_morphology3.03072460
5MP0010352_gastrointestinal_tract_polyps2.57278014
6MP0004272_abnormal_basement_membrane2.49748369
7MP0010234_abnormal_vibrissa_follicle2.47086802
8MP0003566_abnormal_cell_adhesion2.35948539
9MP0009384_cardiac_valve_regurgitation2.32362307
10MP0009780_abnormal_chondrocyte_physiolo2.13183982
11MP0005257_abnormal_intraocular_pressure2.06364364
12MP0002254_reproductive_system_inflammat2.03129517
13MP0002060_abnormal_skin_morphology2.02283270
14MP0010030_abnormal_orbit_morphology2.02072370
15MP0003279_aneurysm1.98108002
16MP0006054_spinal_hemorrhage1.92727931
17MP0005023_abnormal_wound_healing1.90387440
18MP0005623_abnormal_meninges_morphology1.89573516
19MP0009053_abnormal_anal_canal1.89292206
20MP0001958_emphysema1.73472601
21MP0000537_abnormal_urethra_morphology1.73107895
22MP0005360_urolithiasis1.70705934
23MP0003941_abnormal_skin_development1.62459510
24MP0000516_abnormal_urinary_system1.60660055
25MP0005367_renal/urinary_system_phenotyp1.60660055
26MP0005508_abnormal_skeleton_morphology1.59707296
27MP0000733_abnormal_muscle_development1.57940363
28MP0005409_darkened_coat_color1.56189272
29MP0003252_abnormal_bile_duct1.49821038
30MP0003453_abnormal_keratinocyte_physiol1.45513960
31MP0003091_abnormal_cell_migration1.44346556
32MP0003385_abnormal_body_wall1.43305821
33MP0001849_ear_inflammation1.37834305
34MP0004264_abnormal_extraembryonic_tissu1.34287836
35MP0005076_abnormal_cell_differentiation1.32169739
36MP0002877_abnormal_melanocyte_morpholog1.31355677
37MP0000013_abnormal_adipose_tissue1.31222385
38MP0002234_abnormal_pharynx_morphology1.30095074
39MP0002295_abnormal_pulmonary_circulatio1.29522031
40MP0002139_abnormal_hepatobiliary_system1.26687083
41MP0009250_abnormal_appendicular_skeleto1.25203472
42MP0001346_abnormal_lacrimal_gland1.24724007
43MP0000762_abnormal_tongue_morphology1.24655043
44MP0003718_maternal_effect1.24185130
45MP0002796_impaired_skin_barrier1.21706923
46MP0005248_abnormal_Harderian_gland1.20801421
47MP0002896_abnormal_bone_mineralization1.19886992
48MP0000534_abnormal_ureter_morphology1.18421209
49MP0000462_abnormal_digestive_system1.18113278
50MP0001243_abnormal_dermal_layer1.18076762
51MP0000467_abnormal_esophagus_morphology1.17261214
52MP0003300_gastrointestinal_ulcer1.17155431
53MP0000003_abnormal_adipose_tissue1.15410507
54MP0000767_abnormal_smooth_muscle1.14229236
55MP0000751_myopathy1.13880902
56MP0010678_abnormal_skin_adnexa1.13696331
57MP0003755_abnormal_palate_morphology1.10624746
58MP0002282_abnormal_trachea_morphology1.06727064
59MP0002249_abnormal_larynx_morphology1.05132033
60MP0008004_abnormal_stomach_pH1.04923047
61MP0003937_abnormal_limbs/digits/tail_de1.04109806
62MP0000163_abnormal_cartilage_morphology1.02215816
63MP0003868_abnormal_feces_composition1.01918864
64MP0002932_abnormal_joint_morphology1.00775655
65MP0001666_abnormal_nutrient_absorption1.00274463
66MP0002098_abnormal_vibrissa_morphology0.98804467
67MP0002108_abnormal_muscle_morphology0.98451225
68MP0003283_abnormal_digestive_organ0.97767648
69MP0003115_abnormal_respiratory_system0.97228729
70MP0010368_abnormal_lymphatic_system0.96855807
71MP0003950_abnormal_plasma_membrane0.96651872
72MP0005171_absent_coat_pigmentation0.96334467
73MP0003942_abnormal_urinary_system0.95678764
74MP0002233_abnormal_nose_morphology0.95508292
75MP0000428_abnormal_craniofacial_morphol0.95249644
76MP0004858_abnormal_nervous_system0.95023243
77MP0004782_abnormal_surfactant_physiolog0.94875018
78MP0003045_fibrosis0.94869201
79MP0005501_abnormal_skin_physiology0.93917912
80MP0000678_abnormal_parathyroid_gland0.93864519
81MP0005395_other_phenotype0.93828683
82MP0000432_abnormal_head_morphology0.93544778
83MP0005595_abnormal_vascular_smooth0.93526300
84MP0002168_other_aberrant_phenotype0.93278895
85MP0002111_abnormal_tail_morphology0.90221221
86MP0000579_abnormal_nail_morphology0.90191287
87MP0001348_abnormal_lacrimal_gland0.89700060
88MP0009840_abnormal_foam_cell0.89562034
89MP0002115_abnormal_skeleton_extremities0.89241123
90MP0001879_abnormal_lymphatic_vessel0.89197458
91MP0005408_hypopigmentation0.88306116
92MP0005085_abnormal_gallbladder_physiolo0.86043111
93MP0000377_abnormal_hair_follicle0.85239730
94MP0006138_congestive_heart_failure0.84805191
95MP0000383_abnormal_hair_follicle0.84640627
96MP0001542_abnormal_bone_strength0.83517749
97MP0003935_abnormal_craniofacial_develop0.83243008
98MP0001216_abnormal_epidermal_layer0.82863446
99MP0002697_abnormal_eye_size0.82643010
100MP0005390_skeleton_phenotype0.82165022
101MP0000566_synostosis0.81224511
102MP0000538_abnormal_urinary_bladder0.81046650
103MP0000049_abnormal_middle_ear0.79181815
104MP0003191_abnormal_cellular_cholesterol0.77321120
105MP0003448_altered_tumor_morphology0.76659517
106MP0001915_intracranial_hemorrhage0.75362550
107MP0002092_abnormal_eye_morphology0.74914157
108MP0000627_abnormal_mammary_gland0.72495130
109MP0005197_abnormal_uvea_morphology0.72043520
110MP0002113_abnormal_skeleton_development0.71374844
111MP0004185_abnormal_adipocyte_glucose0.71030467
112MP0005164_abnormal_response_to0.70908500
113MP0003806_abnormal_nucleotide_metabolis0.70833382
114MP0005375_adipose_tissue_phenotype0.70816847
115MP0005365_abnormal_bile_salt0.70147917
116MP0000759_abnormal_skeletal_muscle0.70138523
117MP0001299_abnormal_eye_distance/0.69004960
118MP0004134_abnormal_chest_morphology0.68966535
119MP0000427_abnormal_hair_cycle0.68184468
120MP0002109_abnormal_limb_morphology0.67097407
121MP0000613_abnormal_salivary_gland0.66953588
122MP0000477_abnormal_intestine_morphology0.66902209
123MP0010771_integument_phenotype0.66089184
124MP0009379_abnormal_foot_pigmentation0.65050233
125MP0000749_muscle_degeneration0.64722491
126MP0004084_abnormal_cardiac_muscle0.63812386
127MP0001881_abnormal_mammary_gland0.63451620
128MP0003183_abnormal_peptide_metabolism0.60275772
129MP0004233_abnormal_muscle_weight0.58857603
130MP0002133_abnormal_respiratory_system0.58556786
131MP0005388_respiratory_system_phenotype0.58556786
132MP0008789_abnormal_olfactory_epithelium0.57450533
133MP0005165_increased_susceptibility_to0.56695636

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.97049103
2Protrusio acetabuli (HP:0003179)5.90057666
3Atrophic scars (HP:0001075)4.57256464
4Shallow orbits (HP:0000586)4.00803218
5Ankle contracture (HP:0006466)3.97123872
6Right ventricular cardiomyopathy (HP:0011663)3.95853813
7Aortic dissection (HP:0002647)3.86478232
8Cervical subluxation (HP:0003308)3.75427811
9Peritonitis (HP:0002586)3.57077505
10Fragile skin (HP:0001030)3.32404169
11Aortic aneurysm (HP:0004942)3.23589433
12Fragile nails (HP:0001808)3.14792997
13Neonatal short-limb short stature (HP:0008921)3.12258113
14Broad metatarsal (HP:0001783)3.06583846
15Cerebral aneurysm (HP:0004944)3.05220911
16Soft skin (HP:0000977)2.95896975
17Increased connective tissue (HP:0009025)2.92969949
18Plantar hyperkeratosis (HP:0007556)2.85695427
19Blue sclerae (HP:0000592)2.80659074
20Popliteal pterygium (HP:0009756)2.79685775
21Abnormality of dentin (HP:0010299)2.68762096
22Mitral valve prolapse (HP:0001634)2.62698107
23Bladder diverticulum (HP:0000015)2.61600756
24Ulnar bowing (HP:0003031)2.56307711
25Wormian bones (HP:0002645)2.54664258
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.54414708
27Osteolytic defects of the hand bones (HP:0009699)2.54414708
28Dilatation of the ascending aorta (HP:0005111)2.54268705
29Spinal rigidity (HP:0003306)2.49355296
30Alopecia of scalp (HP:0002293)2.47093892
31Spondylolisthesis (HP:0003302)2.45552423
32Abnormality of nail color (HP:0100643)2.44056629
33Mildly elevated creatine phosphokinase (HP:0008180)2.43321120
34Vertebral compression fractures (HP:0002953)2.41793606
35Wrist flexion contracture (HP:0001239)2.41548917
36Spinal cord compression (HP:0002176)2.37597067
37Type 1 muscle fiber predominance (HP:0003803)2.33997112
38Thick nail (HP:0001805)2.28844978
39Abnormality of carpal bone ossification (HP:0006257)2.28341275
40Genu recurvatum (HP:0002816)2.27811702
41Abnormal delivery (HP:0001787)2.26454268
42Tibial bowing (HP:0002982)2.26296876
43Follicular hyperkeratosis (HP:0007502)2.26258214
44Overgrowth (HP:0001548)2.23015611
45Aneurysm (HP:0002617)2.22777704
46Milia (HP:0001056)2.18987146
47Elbow flexion contracture (HP:0002987)2.13906426
48Hyperextensible skin (HP:0000974)2.13879311
49Tarsal synostosis (HP:0008368)2.13760813
50Biconcave vertebral bodies (HP:0004586)2.13245705
51Aortic regurgitation (HP:0001659)2.08619464
52Bell-shaped thorax (HP:0001591)2.07252619
53Knee flexion contracture (HP:0006380)2.06557685
54Joint laxity (HP:0001388)2.06281978
55Infantile muscular hypotonia (HP:0008947)2.05418117
56Camptodactyly of toe (HP:0001836)2.05375026
57Coronal craniosynostosis (HP:0004440)2.04840896
58Ileus (HP:0002595)2.04424051
59Abnormality of the acetabulum (HP:0003170)2.03991499
60Palmoplantar hyperkeratosis (HP:0000972)2.03418581
61Wide anterior fontanel (HP:0000260)2.03134989
62Scapular winging (HP:0003691)2.02121322
63Reduced subcutaneous adipose tissue (HP:0003758)2.02094219
64Mitral stenosis (HP:0001718)2.00071660
65Abnormality of placental membranes (HP:0011409)1.98698362
66Amniotic constriction ring (HP:0009775)1.98698362
67Breech presentation (HP:0001623)1.97770762
68Nail dystrophy (HP:0008404)1.97730169
69Short nail (HP:0001799)1.96800506
70Abnormality of proline metabolism (HP:0010907)1.96061662
71Hydroxyprolinuria (HP:0003080)1.96061662
72Aortic valve stenosis (HP:0001650)1.95614728
73Malnutrition (HP:0004395)1.95570508
74Pterygium (HP:0001059)1.95085621
75Vascular calcification (HP:0004934)1.94694031
76Thin bony cortex (HP:0002753)1.94012004
77Synostosis involving bones of the feet (HP:0009140)1.91521745
78Synostosis involving bones of the lower limbs (HP:0009138)1.91521745
79Fused cervical vertebrae (HP:0002949)1.91440350
80Bowed forearm bones (HP:0003956)1.90150548
81Bowing of the arm (HP:0006488)1.90150548
82Palmar hyperkeratosis (HP:0010765)1.89772704
83Deviation of the hallux (HP:0010051)1.88156947
84Lip pit (HP:0100267)1.87524188
85Vascular tortuosity (HP:0004948)1.87429449
86Cardiovascular calcification (HP:0011915)1.87133839
87Ridged nail (HP:0001807)1.87073820
88Myocardial infarction (HP:0001658)1.86681995
89Pili torti (HP:0003777)1.86578699
90Advanced eruption of teeth (HP:0006288)1.86139216
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.84015670
92Trismus (HP:0000211)1.83429748
93Round ear (HP:0100830)1.82809790
94Mitral regurgitation (HP:0001653)1.80762871
95Bowel diverticulosis (HP:0005222)1.79830511
96Striae distensae (HP:0001065)1.79829132
97Rectal prolapse (HP:0002035)1.79629165
98Limited hip movement (HP:0008800)1.78463721
99Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77527220
100Abnormal hand bone ossification (HP:0010660)1.76791153
101Abnormal vertebral ossification (HP:0100569)1.76642715
102Esophageal varix (HP:0002040)1.76592605
103Flat acetabular roof (HP:0003180)1.76426136
104Short hallux (HP:0010109)1.76150601
105Ankyloglossia (HP:0010296)1.75457454
106Abnormality of the peritoneum (HP:0002585)1.75075375
107Abnormality of the 2nd finger (HP:0004100)1.74983387
108Ectopia lentis (HP:0001083)1.74882426
109Abnormality of the phalanges of the hallux (HP:0010057)1.74353631
110Hallux valgus (HP:0001822)1.74257314
111Subacute progressive viral hepatitis (HP:0006572)1.73252884
112Abnormality of the calcaneus (HP:0008364)1.72860056
113Femoral bowing (HP:0002980)1.72649586
114Radial bowing (HP:0002986)1.72240007
115Abnormality of the distal phalanges of the toes (HP:0010182)1.70897524
116Hip contracture (HP:0003273)1.70230094
117Natal tooth (HP:0000695)1.70113316
118Hypoplastic ischia (HP:0003175)1.70111040
119Mesomelia (HP:0003027)1.69382238
120Cupped ribs (HP:0000887)1.69182349
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68936678
122Vertebral hypoplasia (HP:0008417)1.68936678
123Increased variability in muscle fiber diameter (HP:0003557)1.67890377
124Selective tooth agenesis (HP:0001592)1.67806188
125Onycholysis (HP:0001806)1.67158587
126Hypoplasia of dental enamel (HP:0006297)1.66723717
127Deep venous thrombosis (HP:0002625)1.66715850
128Abnormality of Sharpey fibers (HP:0100685)1.64680380
129Osteoarthritis (HP:0002758)1.63920890
130Arterial tortuosity (HP:0005116)1.63877481
131Nonimmune hydrops fetalis (HP:0001790)1.61823412
132Focal segmental glomerulosclerosis (HP:0000097)1.61483426
133Upper limb amyotrophy (HP:0009129)1.61461933
134Distal upper limb amyotrophy (HP:0007149)1.61461933
135Increased mean platelet volume (HP:0011877)1.61385295
136Hypoplasia of the iris (HP:0007676)1.60383387
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.60177062
138Synostosis of carpal bones (HP:0005048)1.58717107
139Abnormal ossification of hand bones (HP:0005921)1.58006703
140Turricephaly (HP:0000262)1.57223395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.07380710
2LATS13.52494999
3TTN2.96275520
4EPHA22.95457398
5MST1R2.73652832
6MET2.47980998
7PDGFRA2.41336966
8TRIB32.36618343
9FRK2.36036728
10ERN12.21941293
11SIK12.17626440
12RIPK12.17173306
13FER2.03312266
14NTRK11.99112467
15EPHB21.93850660
16PTK61.91194551
17BMX1.83313661
18MAP3K121.82663385
19STK241.82495783
20EPHA31.75894743
21ARAF1.71867801
22CDK121.70754530
23PTK21.69963082
24TRPM71.68588702
25EPHB11.66170203
26PIK3CA1.61037043
27PKN21.60554547
28PAK41.57381113
29STK31.53439988
30PAK21.50024199
31MAP3K101.48752367
32STK38L1.43584811
33LATS21.40647426
34PAK31.33101477
35ERBB41.32754552
36DMPK1.28314286
37MAP3K91.26424215
38LMTK21.22258450
39MST41.21321952
40LRRK21.17401929
41TGFBR21.14640545
42MTOR1.11671192
43FGFR41.11164736
44TESK11.10614656
45ERBB31.09812033
46NUAK11.07647533
47CDK61.07225366
48BRSK21.05462927
49STK101.05357661
50STK381.01791477
51EIF2AK31.01754488
52PDGFRB0.96098001
53NEK90.95794279
54MAP3K30.94940634
55ICK0.94367062
56MAP3K130.94090049
57RPS6KB20.93994330
58MAP2K20.92558861
59ABL20.90748097
60PRKG20.89376579
61MELK0.87062311
62NEK60.85868342
63CDK90.83120422
64PIK3CG0.83045335
65AKT30.81950764
66ERBB20.81574227
67LIMK10.80751772
68RPS6KA40.78002360
69PRKD20.76718411
70DYRK1B0.76653592
71MAP2K10.76092550
72ROCK10.75194672
73CHUK0.75024561
74FGFR10.73964697
75MYLK0.73136952
76CAMK1D0.72497715
77KSR20.69359938
78PIM20.68633333
79GSK3A0.65653617
80MAP3K80.64498524
81MOS0.64179406
82CSK0.63768482
83CDK80.63349181
84BCR0.62616888
85MUSK0.61977120
86NEK10.60755038
87EEF2K0.58066408
88BRAF0.57817244
89CDK70.57605497
90EIF2AK10.56847285
91STK390.56540921
92PBK0.55824264
93ACVR1B0.55461622
94FGFR20.54265303
95INSR0.53093660
96TGFBR10.47592998
97MAP3K20.47351105
98SCYL20.46729961
99CAMK2G0.46393777
100WNK10.45846921
101TYRO30.45065847
102RAF10.44953710
103MAP3K140.44321629
104MAPKAPK20.43996495
105ROCK20.43508780
106JAK10.43397774
107TTK0.42374293
108PAK10.41020195
109PRKCE0.39374313
110FLT30.38729846
111FGFR30.38297625
112RPS6KA20.37860491
113CAMK2D0.37715701
114PNCK0.36968534
115SRC0.35828752
116BRSK10.35477714
117PDK20.35031018
118AURKB0.34945300
119MAPKAPK30.34681176
120PRKCI0.34283669
121PRKAA20.33799135
122PRKD10.33361752
123MAPK150.33278472
124MAPK10.30943160
125MAP3K60.30643767
126PTK2B0.29876496
127CDC42BPA0.29754991
128ABL10.29452899
129MAPK110.28860098
130DAPK30.28728514
131ILK0.28000778
132SMG10.27709877
133MATK0.27430481
134AKT20.26516146

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.96584552
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40211956
3Adherens junction_Homo sapiens_hsa045202.29867965
4Sulfur metabolism_Homo sapiens_hsa009202.08645728
5Focal adhesion_Homo sapiens_hsa045102.08457324
6Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90842662
7Protein digestion and absorption_Homo sapiens_hsa049741.84456534
8Bladder cancer_Homo sapiens_hsa052191.83800188
9Proteoglycans in cancer_Homo sapiens_hsa052051.77898660
10Small cell lung cancer_Homo sapiens_hsa052221.72723777
11Fat digestion and absorption_Homo sapiens_hsa049751.72268087
12Hippo signaling pathway_Homo sapiens_hsa043901.71835028
13TGF-beta signaling pathway_Homo sapiens_hsa043501.62612525
14Tight junction_Homo sapiens_hsa045301.60074489
15Caffeine metabolism_Homo sapiens_hsa002321.58478117
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55063120
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53686963
18Amoebiasis_Homo sapiens_hsa051461.50937100
19Basal cell carcinoma_Homo sapiens_hsa052171.50417047
20Chemical carcinogenesis_Homo sapiens_hsa052041.45963279
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44754104
22Tryptophan metabolism_Homo sapiens_hsa003801.43958857
23Renin-angiotensin system_Homo sapiens_hsa046141.38358936
24MicroRNAs in cancer_Homo sapiens_hsa052061.37787826
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36919240
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.36692685
27Fatty acid degradation_Homo sapiens_hsa000711.35985958
28Complement and coagulation cascades_Homo sapiens_hsa046101.28255108
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28149360
30PPAR signaling pathway_Homo sapiens_hsa033201.25723923
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25490863
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.21667555
33Vitamin digestion and absorption_Homo sapiens_hsa049771.18809361
34Nitrogen metabolism_Homo sapiens_hsa009101.18342580
35Starch and sucrose metabolism_Homo sapiens_hsa005001.17615448
36Sphingolipid metabolism_Homo sapiens_hsa006001.13340266
37Histidine metabolism_Homo sapiens_hsa003401.13331409
38Retinol metabolism_Homo sapiens_hsa008301.12076791
39Mineral absorption_Homo sapiens_hsa049781.11285810
40Malaria_Homo sapiens_hsa051441.10777728
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07928635
42p53 signaling pathway_Homo sapiens_hsa041151.03823136
43Glutathione metabolism_Homo sapiens_hsa004801.02580686
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01461026
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00991659
46Lysine degradation_Homo sapiens_hsa003101.00326851
47Melanoma_Homo sapiens_hsa052180.99041125
48Bile secretion_Homo sapiens_hsa049760.98892473
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97217434
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96155350
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95506614
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94837770
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.93552964
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93332292
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91874786
56Arginine biosynthesis_Homo sapiens_hsa002200.90393039
57Gap junction_Homo sapiens_hsa045400.89663692
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88267247
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.87758868
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87250755
61Selenocompound metabolism_Homo sapiens_hsa004500.86632632
62Hedgehog signaling pathway_Homo sapiens_hsa043400.85766605
63Chronic myeloid leukemia_Homo sapiens_hsa052200.84959696
64Prostate cancer_Homo sapiens_hsa052150.84289145
65Arginine and proline metabolism_Homo sapiens_hsa003300.84180436
66Notch signaling pathway_Homo sapiens_hsa043300.82971130
67Folate biosynthesis_Homo sapiens_hsa007900.81777360
68Fatty acid metabolism_Homo sapiens_hsa012120.81062646
69Dorso-ventral axis formation_Homo sapiens_hsa043200.80705381
70Toxoplasmosis_Homo sapiens_hsa051450.77699651
71Galactose metabolism_Homo sapiens_hsa000520.77050702
72Pathways in cancer_Homo sapiens_hsa052000.76878215
73Cell cycle_Homo sapiens_hsa041100.75793182
74Steroid biosynthesis_Homo sapiens_hsa001000.74615916
75Pancreatic secretion_Homo sapiens_hsa049720.74274981
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69713966
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69324584
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68900928
79Tyrosine metabolism_Homo sapiens_hsa003500.68333941
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68322983
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67447366
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64334587
83Renal cell carcinoma_Homo sapiens_hsa052110.64043679
84Dilated cardiomyopathy_Homo sapiens_hsa054140.63986214
85Vibrio cholerae infection_Homo sapiens_hsa051100.63351859
86Axon guidance_Homo sapiens_hsa043600.63205156
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62727708
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62515151
89Glioma_Homo sapiens_hsa052140.61983982
90TNF signaling pathway_Homo sapiens_hsa046680.61455990
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.60868199
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60156681
93Viral myocarditis_Homo sapiens_hsa054160.59743096
94Shigellosis_Homo sapiens_hsa051310.59513445
95Pancreatic cancer_Homo sapiens_hsa052120.59074543
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.58235847
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58234547
98Melanogenesis_Homo sapiens_hsa049160.58172956
99Endocytosis_Homo sapiens_hsa041440.57593588
100Glycerolipid metabolism_Homo sapiens_hsa005610.57134131
101Fructose and mannose metabolism_Homo sapiens_hsa000510.56851309
102Fatty acid elongation_Homo sapiens_hsa000620.56499799
103N-Glycan biosynthesis_Homo sapiens_hsa005100.56053854
104Circadian rhythm_Homo sapiens_hsa047100.55413203
105Arachidonic acid metabolism_Homo sapiens_hsa005900.55240672
106Thyroid hormone synthesis_Homo sapiens_hsa049180.54116810
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54043270
108Phenylalanine metabolism_Homo sapiens_hsa003600.53708624
109One carbon pool by folate_Homo sapiens_hsa006700.52291477
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51861903
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51446952
112Staphylococcus aureus infection_Homo sapiens_hsa051500.51308609
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.50400094
114Prion diseases_Homo sapiens_hsa050200.50109215
115Apoptosis_Homo sapiens_hsa042100.49786369
116Hepatitis C_Homo sapiens_hsa051600.49751419
117Ovarian steroidogenesis_Homo sapiens_hsa049130.48832481
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48116360
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48038862
120Insulin resistance_Homo sapiens_hsa049310.47189529
121Thyroid cancer_Homo sapiens_hsa052160.47159465
122AMPK signaling pathway_Homo sapiens_hsa041520.47091937
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.46962053
124beta-Alanine metabolism_Homo sapiens_hsa004100.46448638
125Inositol phosphate metabolism_Homo sapiens_hsa005620.45710657
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45500381
127Renin secretion_Homo sapiens_hsa049240.45320089
128Peroxisome_Homo sapiens_hsa041460.44897056
129Rap1 signaling pathway_Homo sapiens_hsa040150.43794700
130Salmonella infection_Homo sapiens_hsa051320.43116864
131Endometrial cancer_Homo sapiens_hsa052130.42607842
132Butanoate metabolism_Homo sapiens_hsa006500.42321457
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.40883150
134Fatty acid biosynthesis_Homo sapiens_hsa000610.40032847
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39847311

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