

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.23740712 |
| 2 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.22884721 |
| 3 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.22884721 |
| 4 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.64316879 |
| 5 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.54092709 |
| 6 | negative T cell selection (GO:0043383) | 5.25333652 |
| 7 | negative thymic T cell selection (GO:0045060) | 5.18427289 |
| 8 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.18039106 |
| 9 | positive thymic T cell selection (GO:0045059) | 5.06488734 |
| 10 | regulation of gamma-delta T cell activation (GO:0046643) | 4.68288176 |
| 11 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.54181958 |
| 12 | negative regulation of cell killing (GO:0031342) | 4.54181958 |
| 13 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.52944073 |
| 14 | leukocyte aggregation (GO:0070486) | 4.51677058 |
| 15 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.49823028 |
| 16 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.49823028 |
| 17 | modulation by symbiont of host immune response (GO:0052553) | 4.49823028 |
| 18 | positive regulation by symbiont of host defense response (GO:0052509) | 4.49823028 |
| 19 | modulation by symbiont of host defense response (GO:0052031) | 4.49823028 |
| 20 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.49823028 |
| 21 | thymic T cell selection (GO:0045061) | 4.42908796 |
| 22 | positive T cell selection (GO:0043368) | 4.40837304 |
| 23 | detection of bacterium (GO:0016045) | 4.38475953 |
| 24 | detection of other organism (GO:0098543) | 4.30108935 |
| 25 | ribosomal small subunit assembly (GO:0000028) | 4.28368505 |
| 26 | viral transcription (GO:0019083) | 4.23320209 |
| 27 | response to interleukin-15 (GO:0070672) | 4.23268959 |
| 28 | neutrophil activation involved in immune response (GO:0002283) | 4.16499663 |
| 29 | T cell selection (GO:0045058) | 4.16160655 |
| 30 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 4.07232301 |
| 31 | antigen processing and presentation via MHC class Ib (GO:0002475) | 4.01833425 |
| 32 | translational termination (GO:0006415) | 4.01395869 |
| 33 | sequestering of actin monomers (GO:0042989) | 4.00722203 |
| 34 | cellular response to interleukin-15 (GO:0071350) | 3.98770604 |
| 35 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.93284595 |
| 36 | interferon-gamma production (GO:0032609) | 3.88165527 |
| 37 | T cell migration (GO:0072678) | 3.86373717 |
| 38 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.80745929 |
| 39 | B cell receptor signaling pathway (GO:0050853) | 3.79584379 |
| 40 | T cell receptor signaling pathway (GO:0050852) | 3.75012702 |
| 41 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.68953331 |
| 42 | respiratory burst (GO:0045730) | 3.68870341 |
| 43 | macrophage activation involved in immune response (GO:0002281) | 3.68315686 |
| 44 | regulation of B cell differentiation (GO:0045577) | 3.68084640 |
| 45 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.67166052 |
| 46 | negative regulation of T cell mediated immunity (GO:0002710) | 3.63706952 |
| 47 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.60163307 |
| 48 | translational elongation (GO:0006414) | 3.57466785 |
| 49 | DNA deamination (GO:0045006) | 3.56186412 |
| 50 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.55608408 |
| 51 | T cell costimulation (GO:0031295) | 3.55305307 |
| 52 | cellular extravasation (GO:0045123) | 3.54542955 |
| 53 | negative regulation of interleukin-12 production (GO:0032695) | 3.51689630 |
| 54 | lymphocyte costimulation (GO:0031294) | 3.50926409 |
| 55 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.50683198 |
| 56 | negative regulation of phagocytosis (GO:0050765) | 3.45902771 |
| 57 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.45069024 |
| 58 | positive regulation of B cell differentiation (GO:0045579) | 3.42305275 |
| 59 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.40622979 |
| 60 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.39897978 |
| 61 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.39897978 |
| 62 | defense response to protozoan (GO:0042832) | 3.39074640 |
| 63 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.39035922 |
| 64 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.38243069 |
| 65 | neutrophil activation (GO:0042119) | 3.38196223 |
| 66 | response to muramyl dipeptide (GO:0032495) | 3.37443305 |
| 67 | B cell mediated immunity (GO:0019724) | 3.36147044 |
| 68 | response to peptidoglycan (GO:0032494) | 3.35287181 |
| 69 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.35097768 |
| 70 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.33422370 |
| 71 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.32983745 |
| 72 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.30659729 |
| 73 | T cell homeostasis (GO:0043029) | 3.30550851 |
| 74 | detection of external biotic stimulus (GO:0098581) | 3.29858297 |
| 75 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.29684460 |
| 76 | mast cell activation (GO:0045576) | 3.29032298 |
| 77 | ribosomal small subunit biogenesis (GO:0042274) | 3.29010636 |
| 78 | cotranslational protein targeting to membrane (GO:0006613) | 3.28941765 |
| 79 | tolerance induction (GO:0002507) | 3.28785507 |
| 80 | protein targeting to ER (GO:0045047) | 3.28705232 |
| 81 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.28335534 |
| 82 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.25511010 |
| 83 | negative regulation of innate immune response (GO:0045824) | 3.24863716 |
| 84 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.23166310 |
| 85 | Peyers patch development (GO:0048541) | 3.23166310 |
| 86 | myeloid cell activation involved in immune response (GO:0002275) | 3.23093944 |
| 87 | NIK/NF-kappaB signaling (GO:0038061) | 3.22151266 |
| 88 | regulation of T cell tolerance induction (GO:0002664) | 3.21156495 |
| 89 | regulation of mast cell degranulation (GO:0043304) | 3.21136529 |
| 90 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.15512160 |
| 91 | response to host immune response (GO:0052572) | 3.15512160 |
| 92 | viral life cycle (GO:0019058) | 3.13976916 |
| 93 | positive regulation of tolerance induction (GO:0002645) | 3.13945233 |
| 94 | positive regulation of lamellipodium assembly (GO:0010592) | 3.13485166 |
| 95 | regulation of antigen processing and presentation (GO:0002577) | 3.13470696 |
| 96 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.11912637 |
| 97 | cellular protein complex disassembly (GO:0043624) | 3.11775770 |
| 98 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.11100286 |
| 99 | protein localization to endoplasmic reticulum (GO:0070972) | 3.08765137 |
| 100 | response to protozoan (GO:0001562) | 3.05886227 |
| 101 | leukocyte degranulation (GO:0043299) | 3.04988310 |
| 102 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.04967091 |
| 103 | granulocyte activation (GO:0036230) | 3.04700692 |
| 104 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.02554636 |
| 105 | positive regulation of antigen processing and presentation (GO:0002579) | 2.98643654 |
| 106 | maturation of SSU-rRNA (GO:0030490) | 2.95938082 |
| 107 | regulation of regulatory T cell differentiation (GO:0045589) | 2.94885859 |
| 108 | protein complex disassembly (GO:0043241) | 2.94264679 |
| 109 | translational initiation (GO:0006413) | 2.94249397 |
| 110 | germinal center formation (GO:0002467) | 2.91772281 |
| 111 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.91334451 |
| 112 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.91111774 |
| 113 | response to host (GO:0075136) | 2.91111774 |
| 114 | response to host defenses (GO:0052200) | 2.91111774 |
| 115 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.90436965 |
| 116 | positive regulation of isotype switching (GO:0045830) | 2.89183025 |
| 117 | regulation of response to interferon-gamma (GO:0060330) | 2.88111698 |
| 118 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.87044887 |
| 119 | lymphocyte homeostasis (GO:0002260) | 2.86703233 |
| 120 | immunoglobulin mediated immune response (GO:0016064) | 2.83827310 |
| 121 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.81481217 |
| 122 | positive regulation of interleukin-2 production (GO:0032743) | 2.80456414 |
| 123 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 2.80032177 |
| 124 | response to type I interferon (GO:0034340) | 2.78824314 |
| 125 | mast cell degranulation (GO:0043303) | 2.76756640 |
| 126 | mast cell activation involved in immune response (GO:0002279) | 2.76756640 |
| 127 | cellular response to type I interferon (GO:0071357) | 2.75653196 |
| 128 | type I interferon signaling pathway (GO:0060337) | 2.75653196 |
| 129 | regulation of tolerance induction (GO:0002643) | 2.73597175 |
| 130 | macromolecular complex disassembly (GO:0032984) | 2.72109493 |
| 131 | cellular response to zinc ion (GO:0071294) | 2.72035607 |
| 132 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.71145132 |
| 133 | actin nucleation (GO:0045010) | 2.70446875 |
| 134 | V(D)J recombination (GO:0033151) | 2.69399011 |
| 135 | cellular response to interleukin-4 (GO:0071353) | 2.68717013 |
| 136 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.67716920 |
| 137 | regulation of defense response to virus by virus (GO:0050690) | 2.67597779 |
| 138 | T cell differentiation (GO:0030217) | 2.66185323 |
| 139 | positive regulation of granulocyte differentiation (GO:0030854) | 2.66072464 |
| 140 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.65551374 |
| 141 | mature B cell differentiation (GO:0002335) | 2.63255984 |
| 142 | activated T cell proliferation (GO:0050798) | 2.61854725 |
| 143 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.61648769 |
| 144 | myeloid dendritic cell activation (GO:0001773) | 2.61537029 |
| 145 | positive regulation of lamellipodium organization (GO:1902745) | 2.61339032 |
| 146 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.60966378 |
| 147 | leukocyte cell-cell adhesion (GO:0007159) | 2.58340848 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.83599028 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.01478856 |
| 3 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.78032921 |
| 4 | * MYC_22102868_ChIP-Seq_BL_Human | 3.54928207 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.45816999 |
| 6 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.45424746 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.11673538 |
| 8 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.87884639 |
| 9 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.85801326 |
| 10 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.79968566 |
| 11 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.78349562 |
| 12 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.59969853 |
| 13 | * RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.54140130 |
| 14 | MYB_26560356_Chip-Seq_TH2_Human | 2.52234325 |
| 15 | * MAF_26560356_Chip-Seq_TH1_Human | 2.49504439 |
| 16 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.44950512 |
| 17 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.42849009 |
| 18 | * UTX_26944678_Chip-Seq_JUKART_Human | 2.36091177 |
| 19 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.32640261 |
| 20 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.29034585 |
| 21 | MYB_26560356_Chip-Seq_TH1_Human | 2.23584681 |
| 22 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.22810577 |
| 23 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.19724236 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.18950827 |
| 25 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.18683829 |
| 26 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.14829001 |
| 27 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.14167559 |
| 28 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.10321621 |
| 29 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.08490718 |
| 30 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.06329897 |
| 31 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.05294864 |
| 32 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.03225770 |
| 33 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.00523903 |
| 34 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.99915391 |
| 35 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.95521499 |
| 36 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.95431520 |
| 37 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.93063660 |
| 38 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.91391660 |
| 39 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.90616466 |
| 40 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.87688143 |
| 41 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.83625624 |
| 42 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.82394580 |
| 43 | * MAF_26560356_Chip-Seq_TH2_Human | 1.82165636 |
| 44 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79933967 |
| 45 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.76664461 |
| 46 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72783321 |
| 47 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.60974892 |
| 48 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.60539973 |
| 49 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.60517863 |
| 50 | * BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.59444655 |
| 51 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.59123308 |
| 52 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.58685321 |
| 53 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58312515 |
| 54 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.53862999 |
| 55 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.50417008 |
| 56 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.49410204 |
| 57 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.48206805 |
| 58 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.46078855 |
| 59 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.44312681 |
| 60 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.42807916 |
| 61 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.41741502 |
| 62 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.39918909 |
| 63 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.39726876 |
| 64 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.38953539 |
| 65 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.37486680 |
| 66 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.37190262 |
| 67 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.36191771 |
| 68 | GATA3_26560356_Chip-Seq_TH2_Human | 1.35905322 |
| 69 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.35063836 |
| 70 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.33611465 |
| 71 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.32645975 |
| 72 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.32633043 |
| 73 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.32118229 |
| 74 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.31656427 |
| 75 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.28708399 |
| 76 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27766535 |
| 77 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.27431673 |
| 78 | SPI1_23127762_ChIP-Seq_K562_Human | 1.26755694 |
| 79 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.26340339 |
| 80 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.24123141 |
| 81 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.23945211 |
| 82 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.23111742 |
| 83 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.22510855 |
| 84 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.22095151 |
| 85 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.20717479 |
| 86 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.20598826 |
| 87 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.17941124 |
| 88 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.16926563 |
| 89 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13205783 |
| 90 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.12380478 |
| 91 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.10610177 |
| 92 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.10411269 |
| 93 | P68_20966046_ChIP-Seq_HELA_Human | 1.10142940 |
| 94 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09890870 |
| 95 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.09605037 |
| 96 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.07979211 |
| 97 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.07124569 |
| 98 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07002417 |
| 99 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.06496506 |
| 100 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.05745691 |
| 101 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.05661850 |
| 102 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.05395564 |
| 103 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.04341060 |
| 104 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.02711929 |
| 105 | * TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.02337933 |
| 106 | * RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02302231 |
| 107 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.01939926 |
| 108 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.01356392 |
| 109 | P300_27268052_Chip-Seq_Bcells_Human | 1.01324288 |
| 110 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00557550 |
| 111 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.00199065 |
| 112 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.99496279 |
| 113 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.97747419 |
| 114 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.97442023 |
| 115 | * GATA1_19941826_ChIP-Seq_K562_Human | 0.97184760 |
| 116 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.96899429 |
| 117 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.96081793 |
| 118 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.95974746 |
| 119 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.95844008 |
| 120 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.95608002 |
| 121 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.95499665 |
| 122 | * CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.94390166 |
| 123 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.94114830 |
| 124 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.93857707 |
| 125 | * CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.92303260 |
| 126 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.92180798 |
| 127 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.90750023 |
| 128 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.90301319 |
| 129 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.89717832 |
| 130 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89530280 |
| 131 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.87431101 |
| 132 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85619451 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 4.42693889 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.84036089 |
| 3 | MP0000685_abnormal_immune_system | 3.82211948 |
| 4 | MP0005671_abnormal_response_to | 3.65139560 |
| 5 | MP0001800_abnormal_humoral_immune | 3.21251027 |
| 6 | MP0002396_abnormal_hematopoietic_system | 2.98745972 |
| 7 | MP0002398_abnormal_bone_marrow | 2.92240526 |
| 8 | MP0001790_abnormal_immune_system | 2.84727981 |
| 9 | MP0005387_immune_system_phenotype | 2.84727981 |
| 10 | MP0002420_abnormal_adaptive_immunity | 2.82021875 |
| 11 | MP0001819_abnormal_immune_cell | 2.77411890 |
| 12 | MP0009785_altered_susceptibility_to | 2.75122359 |
| 13 | MP0002452_abnormal_antigen_presenting | 2.73877335 |
| 14 | MP0002723_abnormal_immune_serum | 2.72502947 |
| 15 | MP0005000_abnormal_immune_tolerance | 2.70139743 |
| 16 | MP0003436_decreased_susceptibility_to | 2.56977468 |
| 17 | MP0000716_abnormal_immune_system | 2.52257631 |
| 18 | MP0002166_altered_tumor_susceptibility | 2.51761322 |
| 19 | MP0005025_abnormal_response_to | 2.46243872 |
| 20 | MP0000703_abnormal_thymus_morphology | 2.45826726 |
| 21 | MP0009333_abnormal_splenocyte_physiolog | 2.42481593 |
| 22 | MP0000689_abnormal_spleen_morphology | 2.37996499 |
| 23 | MP0002722_abnormal_immune_system | 2.37321563 |
| 24 | MP0004808_abnormal_hematopoietic_stem | 2.32125193 |
| 25 | MP0002405_respiratory_system_inflammati | 2.31910497 |
| 26 | MP0003303_peritoneal_inflammation | 2.31746514 |
| 27 | MP0001873_stomach_inflammation | 2.20086608 |
| 28 | MP0002429_abnormal_blood_cell | 2.15958035 |
| 29 | MP0002419_abnormal_innate_immunity | 1.97573145 |
| 30 | MP0010155_abnormal_intestine_physiology | 1.94499840 |
| 31 | MP0005464_abnormal_platelet_physiology | 1.89755772 |
| 32 | MP0002006_tumorigenesis | 1.89220854 |
| 33 | MP0002148_abnormal_hypersensitivity_rea | 1.88294223 |
| 34 | MP0003866_abnormal_defecation | 1.84963072 |
| 35 | MP0003693_abnormal_embryo_hatching | 1.76372772 |
| 36 | MP0003300_gastrointestinal_ulcer | 1.72425189 |
| 37 | MP0001853_heart_inflammation | 1.71611649 |
| 38 | MP0005410_abnormal_fertilization | 1.70455138 |
| 39 | MP0001545_abnormal_hematopoietic_system | 1.64135436 |
| 40 | MP0005397_hematopoietic_system_phenotyp | 1.64135436 |
| 41 | MP0002933_joint_inflammation | 1.63013883 |
| 42 | MP0000465_gastrointestinal_hemorrhage | 1.62378473 |
| 43 | MP0001845_abnormal_inflammatory_respons | 1.61766205 |
| 44 | MP0000490_abnormal_crypts_of | 1.61471827 |
| 45 | MP0003724_increased_susceptibility_to | 1.60542325 |
| 46 | MP0003191_abnormal_cellular_cholesterol | 1.57730735 |
| 47 | MP0006082_CNS_inflammation | 1.57491465 |
| 48 | MP0004947_skin_inflammation | 1.56370922 |
| 49 | MP0009278_abnormal_bone_marrow | 1.53446243 |
| 50 | MP0003077_abnormal_cell_cycle | 1.52876106 |
| 51 | MP0010094_abnormal_chromosome_stability | 1.51053903 |
| 52 | MP0005174_abnormal_tail_pigmentation | 1.50760768 |
| 53 | MP0002138_abnormal_hepatobiliary_system | 1.38919032 |
| 54 | MP0005075_abnormal_melanosome_morpholog | 1.36904301 |
| 55 | MP0004510_myositis | 1.35584922 |
| 56 | MP0002019_abnormal_tumor_incidence | 1.35075644 |
| 57 | MP0000858_altered_metastatic_potential | 1.34871105 |
| 58 | MP0004957_abnormal_blastocyst_morpholog | 1.33281643 |
| 59 | MP0008007_abnormal_cellular_replicative | 1.32813025 |
| 60 | MP0008260_abnormal_autophagy | 1.31379522 |
| 61 | MP0003111_abnormal_nucleus_morphology | 1.23494962 |
| 62 | MP0008057_abnormal_DNA_replication | 1.19968722 |
| 63 | MP0008058_abnormal_DNA_repair | 1.18314965 |
| 64 | MP0002277_abnormal_respiratory_mucosa | 1.12781342 |
| 65 | MP0003828_pulmonary_edema | 1.12264237 |
| 66 | MP0008469_abnormal_protein_level | 1.09507175 |
| 67 | MP0001533_abnormal_skeleton_physiology | 1.02244370 |
| 68 | MP0005310_abnormal_salivary_gland | 0.99917739 |
| 69 | MP0002132_abnormal_respiratory_system | 0.97101692 |
| 70 | MP0002009_preneoplasia | 0.96133120 |
| 71 | MP0005451_abnormal_body_composition | 0.90451909 |
| 72 | MP0000313_abnormal_cell_death | 0.89852543 |
| 73 | MP0002095_abnormal_skin_pigmentation | 0.89587860 |
| 74 | MP0003448_altered_tumor_morphology | 0.89008799 |
| 75 | MP0001986_abnormal_taste_sensitivity | 0.87050247 |
| 76 | MP0005166_decreased_susceptibility_to | 0.84877689 |
| 77 | MP0010352_gastrointestinal_tract_polyps | 0.81604511 |
| 78 | MP0004883_abnormal_blood_vessel | 0.80581392 |
| 79 | MP0008877_abnormal_DNA_methylation | 0.79752130 |
| 80 | MP0001929_abnormal_gametogenesis | 0.78153649 |
| 81 | MP0001851_eye_inflammation | 0.77542299 |
| 82 | MP0000015_abnormal_ear_pigmentation | 0.77328852 |
| 83 | MP0005058_abnormal_lysosome_morphology | 0.77316473 |
| 84 | MP0000350_abnormal_cell_proliferation | 0.77141636 |
| 85 | MP0006054_spinal_hemorrhage | 0.76855964 |
| 86 | MP0003075_altered_response_to | 0.75302804 |
| 87 | MP0005390_skeleton_phenotype | 0.75294312 |
| 88 | MP0005023_abnormal_wound_healing | 0.74651265 |
| 89 | MP0004381_abnormal_hair_follicle | 0.69380672 |
| 90 | MP0010307_abnormal_tumor_latency | 0.68217596 |
| 91 | MP0000477_abnormal_intestine_morphology | 0.68125071 |
| 92 | MP0003806_abnormal_nucleotide_metabolis | 0.66805981 |
| 93 | MP0003786_premature_aging | 0.65060450 |
| 94 | MP0003172_abnormal_lysosome_physiology | 0.63600444 |
| 95 | MP0001663_abnormal_digestive_system | 0.63307321 |
| 96 | MP0001730_embryonic_growth_arrest | 0.60717831 |
| 97 | MP0003183_abnormal_peptide_metabolism | 0.57201338 |
| 98 | MP0002693_abnormal_pancreas_physiology | 0.56585726 |
| 99 | MP0000604_amyloidosis | 0.54720854 |
| 100 | MP0008874_decreased_physiological_sensi | 0.54262285 |
| 101 | MP0001348_abnormal_lacrimal_gland | 0.53474987 |
| 102 | MP0003690_abnormal_glial_cell | 0.52554834 |
| 103 | MP0003698_abnormal_male_reproductive | 0.51847669 |
| 104 | MP0009763_increased_sensitivity_to | 0.51467310 |
| 105 | MP0005076_abnormal_cell_differentiation | 0.50620490 |
| 106 | MP0002080_prenatal_lethality | 0.50542999 |
| 107 | MP0008961_abnormal_basal_metabolism | 0.50283312 |
| 108 | MP0008004_abnormal_stomach_pH | 0.49556429 |
| 109 | MP0005381_digestive/alimentary_phenotyp | 0.48151507 |
| 110 | MP0005164_abnormal_response_to | 0.48126608 |
| 111 | MP0002928_abnormal_bile_duct | 0.48025422 |
| 112 | MP0003943_abnormal_hepatobiliary_system | 0.47847156 |
| 113 | MP0003045_fibrosis | 0.47659771 |
| 114 | MP0002210_abnormal_sex_determination | 0.47538776 |
| 115 | MP0009765_abnormal_xenobiotic_induced | 0.47252308 |
| 116 | MP0004130_abnormal_muscle_cell | 0.46981926 |
| 117 | MP0003795_abnormal_bone_structure | 0.44925721 |
| 118 | MP0002653_abnormal_ependyma_morphology | 0.44091239 |
| 119 | MP0009764_decreased_sensitivity_to | 0.43507343 |
| 120 | MP0002083_premature_death | 0.43329496 |
| 121 | MP0008873_increased_physiological_sensi | 0.42834528 |
| 122 | MP0000249_abnormal_blood_vessel | 0.42323181 |
| 123 | MP0001145_abnormal_male_reproductive | 0.42259704 |
| 124 | MP0002998_abnormal_bone_remodeling | 0.42238185 |
| 125 | MP0009840_abnormal_foam_cell | 0.41651058 |
| 126 | MP0002136_abnormal_kidney_physiology | 0.41554044 |
| 127 | MP0002254_reproductive_system_inflammat | 0.40664695 |
| 128 | MP0000609_abnormal_liver_physiology | 0.40042340 |
| 129 | MP0005319_abnormal_enzyme/_coenzyme | 0.39412250 |
| 130 | MP0009642_abnormal_blood_homeostasis | 0.38215198 |
| 131 | MP0003252_abnormal_bile_duct | 0.37668009 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent bronchitis (HP:0002837) | 5.57836944 |
| 2 | Nasal polyposis (HP:0100582) | 5.20289909 |
| 3 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.02475324 |
| 4 | T lymphocytopenia (HP:0005403) | 4.86210837 |
| 5 | Chronic otitis media (HP:0000389) | 4.85886553 |
| 6 | IgM deficiency (HP:0002850) | 4.85280859 |
| 7 | Abnormality of T cell number (HP:0011839) | 4.63523468 |
| 8 | Abnormality of the nasal mucosa (HP:0000433) | 4.62184769 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 4.58172468 |
| 10 | Abnormality of T cells (HP:0002843) | 4.34885709 |
| 11 | Recurrent viral infections (HP:0004429) | 4.16964381 |
| 12 | Recurrent fungal infections (HP:0002841) | 4.09755050 |
| 13 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.06091003 |
| 14 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.97841151 |
| 15 | Agammaglobulinemia (HP:0004432) | 3.90015584 |
| 16 | Severe combined immunodeficiency (HP:0004430) | 3.86990791 |
| 17 | Thrombocytosis (HP:0001894) | 3.85139226 |
| 18 | Bronchitis (HP:0012387) | 3.85071279 |
| 19 | IgG deficiency (HP:0004315) | 3.76202938 |
| 20 | Eczematoid dermatitis (HP:0000976) | 3.73548762 |
| 21 | Myositis (HP:0100614) | 3.72190919 |
| 22 | B lymphocytopenia (HP:0010976) | 3.68942618 |
| 23 | Abnormality of B cell number (HP:0010975) | 3.68942618 |
| 24 | Gastrointestinal infarctions (HP:0005244) | 3.68831964 |
| 25 | Combined immunodeficiency (HP:0005387) | 3.66009723 |
| 26 | Abnormality of T cell physiology (HP:0011840) | 3.58310155 |
| 27 | Recurrent cutaneous fungal infections (HP:0011370) | 3.57794703 |
| 28 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.57794703 |
| 29 | Recurrent sinusitis (HP:0011108) | 3.55111819 |
| 30 | Lymphopenia (HP:0001888) | 3.54807568 |
| 31 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.52446863 |
| 32 | Meningitis (HP:0001287) | 3.52129957 |
| 33 | Recurrent abscess formation (HP:0002722) | 3.51280578 |
| 34 | Gastrointestinal inflammation (HP:0004386) | 3.34651759 |
| 35 | Inflammation of the large intestine (HP:0002037) | 3.30174830 |
| 36 | Stomatitis (HP:0010280) | 3.28098541 |
| 37 | Chronic sinusitis (HP:0011109) | 3.20442567 |
| 38 | Thyroiditis (HP:0100646) | 3.16929576 |
| 39 | Cellulitis (HP:0100658) | 3.09186759 |
| 40 | Urticaria (HP:0001025) | 3.08627304 |
| 41 | Verrucae (HP:0200043) | 2.95958125 |
| 42 | Papilloma (HP:0012740) | 2.95958125 |
| 43 | Keratoconjunctivitis sicca (HP:0001097) | 2.93698330 |
| 44 | Reticulocytopenia (HP:0001896) | 2.92823854 |
| 45 | Recurrent bacterial skin infections (HP:0005406) | 2.90090148 |
| 46 | Gingivitis (HP:0000230) | 2.83595475 |
| 47 | Mediastinal lymphadenopathy (HP:0100721) | 2.82562010 |
| 48 | Hypochromic anemia (HP:0001931) | 2.81478229 |
| 49 | Abnormality of eosinophils (HP:0001879) | 2.80753444 |
| 50 | Eosinophilia (HP:0001880) | 2.79511063 |
| 51 | Recurrent skin infections (HP:0001581) | 2.77338889 |
| 52 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.77025031 |
| 53 | Obstructive lung disease (HP:0006536) | 2.76561382 |
| 54 | Chronic obstructive pulmonary disease (HP:0006510) | 2.76561382 |
| 55 | Pustule (HP:0200039) | 2.76085951 |
| 56 | Keratoconjunctivitis (HP:0001096) | 2.74331103 |
| 57 | Granulocytopenia (HP:0001913) | 2.72233403 |
| 58 | Spontaneous hematomas (HP:0007420) | 2.71779543 |
| 59 | Abnormality of the fingertips (HP:0001211) | 2.71601018 |
| 60 | Colitis (HP:0002583) | 2.70930630 |
| 61 | Vasculitis (HP:0002633) | 2.69858977 |
| 62 | Lymphoma (HP:0002665) | 2.65681108 |
| 63 | Abnormal number of erythroid precursors (HP:0012131) | 2.65650276 |
| 64 | Recurrent otitis media (HP:0000403) | 2.63623888 |
| 65 | Gastrointestinal stroma tumor (HP:0100723) | 2.60171290 |
| 66 | Leukocytosis (HP:0001974) | 2.60108755 |
| 67 | Basal cell carcinoma (HP:0002671) | 2.58387381 |
| 68 | Hypochromic microcytic anemia (HP:0004840) | 2.56191597 |
| 69 | Chronic diarrhea (HP:0002028) | 2.51311005 |
| 70 | Bronchiectasis (HP:0002110) | 2.48065612 |
| 71 | Episodic fever (HP:0001954) | 2.46436178 |
| 72 | Gingival bleeding (HP:0000225) | 2.44565841 |
| 73 | Recurrent pneumonia (HP:0006532) | 2.39541914 |
| 74 | Poikiloderma (HP:0001029) | 2.39399768 |
| 75 | Aplastic anemia (HP:0001915) | 2.37659150 |
| 76 | Hypoplasia of the thymus (HP:0000778) | 2.35320214 |
| 77 | Pulmonary embolism (HP:0002204) | 2.34187004 |
| 78 | Arterial thrombosis (HP:0004420) | 2.27539593 |
| 79 | Abnormality of the pleura (HP:0002103) | 2.26990227 |
| 80 | Prolonged bleeding time (HP:0003010) | 2.26592339 |
| 81 | Hypergammaglobulinemia (HP:0010702) | 2.25355469 |
| 82 | Anorexia (HP:0002039) | 2.25303804 |
| 83 | Recurrent lower respiratory tract infections (HP:0002783) | 2.24574718 |
| 84 | IgA deficiency (HP:0002720) | 2.24211943 |
| 85 | Increased IgE level (HP:0003212) | 2.23548234 |
| 86 | Emphysema (HP:0002097) | 2.19510423 |
| 87 | Hemoptysis (HP:0002105) | 2.18459321 |
| 88 | Petechiae (HP:0000967) | 2.18128095 |
| 89 | Encephalitis (HP:0002383) | 2.18122308 |
| 90 | Chest pain (HP:0100749) | 2.16167859 |
| 91 | Purpura (HP:0000979) | 2.14972509 |
| 92 | Autoimmune thrombocytopenia (HP:0001973) | 2.14352816 |
| 93 | Abnormality of the prostate (HP:0008775) | 2.14275831 |
| 94 | Abnormality of the peritoneum (HP:0002585) | 2.12921965 |
| 95 | Microcytic anemia (HP:0001935) | 2.12010208 |
| 96 | Autoimmune hemolytic anemia (HP:0001890) | 2.11618527 |
| 97 | Interstitial pulmonary disease (HP:0006530) | 2.09995825 |
| 98 | Epistaxis (HP:0000421) | 2.07682461 |
| 99 | Pallor (HP:0000980) | 2.06353964 |
| 100 | Viral hepatitis (HP:0006562) | 2.06137702 |
| 101 | Increased IgM level (HP:0003496) | 2.03328989 |
| 102 | Hypertensive crisis (HP:0100735) | 2.01706113 |
| 103 | Gangrene (HP:0100758) | 1.99447172 |
| 104 | Joint swelling (HP:0001386) | 1.99278294 |
| 105 | Amaurosis fugax (HP:0100576) | 1.96443457 |
| 106 | Orchitis (HP:0100796) | 1.94047527 |
| 107 | Increased serum ferritin (HP:0003281) | 1.93739940 |
| 108 | Slow saccadic eye movements (HP:0000514) | 1.91784173 |
| 109 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.91388957 |
| 110 | Acute hepatic failure (HP:0006554) | 1.91135307 |
| 111 | Hepatosplenomegaly (HP:0001433) | 1.91013392 |
| 112 | Increased density of long bones (HP:0006392) | 1.90263330 |
| 113 | Entropion (HP:0000621) | 1.89304281 |
| 114 | Skin ulcer (HP:0200042) | 1.88753246 |
| 115 | Osteomyelitis (HP:0002754) | 1.87701193 |
| 116 | Pulmonary infiltrates (HP:0002113) | 1.86692817 |
| 117 | Impaired platelet aggregation (HP:0003540) | 1.83545103 |
| 118 | Abnormal platelet function (HP:0011869) | 1.83545103 |
| 119 | Sepsis (HP:0100806) | 1.82464573 |
| 120 | Macrocytic anemia (HP:0001972) | 1.82209873 |
| 121 | Retrobulbar optic neuritis (HP:0100654) | 1.79973764 |
| 122 | Optic neuritis (HP:0100653) | 1.79973764 |
| 123 | Bicuspid aortic valve (HP:0001647) | 1.78149467 |
| 124 | Abnormality of macrophages (HP:0004311) | 1.75921311 |
| 125 | Skin rash (HP:0000988) | 1.74690880 |
| 126 | Fatigue (HP:0012378) | 1.72904997 |
| 127 | Restrictive lung disease (HP:0002091) | 1.71384076 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 5.42397025 |
| 2 | TXK | 3.35592275 |
| 3 | ZAP70 | 3.03428865 |
| 4 | MAP3K10 | 2.91543765 |
| 5 | GRK6 | 2.49118701 |
| 6 | PRPF4B | 2.39549484 |
| 7 | EEF2K | 2.37720774 |
| 8 | JAK3 | 2.37477634 |
| 9 | TESK2 | 2.35206811 |
| 10 | BTK | 2.21032212 |
| 11 | STK10 | 2.19004092 |
| 12 | BLK | 2.15730636 |
| 13 | TYK2 | 2.13557831 |
| 14 | ITK | 2.10260961 |
| 15 | IKBKE | 1.96993176 |
| 16 | KDR | 1.94033450 |
| 17 | TEC | 1.92446930 |
| 18 | KIT | 1.89922810 |
| 19 | TESK1 | 1.87085909 |
| 20 | SYK | 1.79879076 |
| 21 | TAOK3 | 1.78573739 |
| 22 | NLK | 1.76606554 |
| 23 | NME2 | 1.75334652 |
| 24 | TBK1 | 1.70212923 |
| 25 | CSF1R | 1.61646931 |
| 26 | LCK | 1.61621355 |
| 27 | FGFR4 | 1.61598386 |
| 28 | IRAK4 | 1.60401883 |
| 29 | LRRK2 | 1.55351485 |
| 30 | RPS6KA4 | 1.37369298 |
| 31 | ERN1 | 1.36704442 |
| 32 | PKN2 | 1.35972679 |
| 33 | CSK | 1.34687450 |
| 34 | CLK1 | 1.33917632 |
| 35 | FES | 1.32862699 |
| 36 | FLT3 | 1.31673486 |
| 37 | HCK | 1.30880649 |
| 38 | NEK2 | 1.30552642 |
| 39 | TLK1 | 1.28624568 |
| 40 | BUB1 | 1.28111814 |
| 41 | TRIB3 | 1.20778589 |
| 42 | MAP3K1 | 1.09620713 |
| 43 | MAP2K3 | 1.09041675 |
| 44 | MAP3K3 | 1.08031019 |
| 45 | TGFBR2 | 1.07671671 |
| 46 | JAK1 | 1.07083964 |
| 47 | LYN | 1.05688453 |
| 48 | TGFBR1 | 1.03118865 |
| 49 | FGFR3 | 1.02044287 |
| 50 | PIM1 | 0.93647740 |
| 51 | FGR | 0.92576744 |
| 52 | CDC7 | 0.92502669 |
| 53 | MAP3K14 | 0.91965749 |
| 54 | SMG1 | 0.91657233 |
| 55 | PASK | 0.87829554 |
| 56 | IKBKB | 0.86570167 |
| 57 | RIPK4 | 0.85473844 |
| 58 | CDK4 | 0.85079383 |
| 59 | TNK2 | 0.83942913 |
| 60 | SIK2 | 0.82188145 |
| 61 | CAMKK1 | 0.81438202 |
| 62 | TAOK2 | 0.74494106 |
| 63 | MATK | 0.74237952 |
| 64 | MARK3 | 0.73747274 |
| 65 | MAPK12 | 0.69925047 |
| 66 | ACVR1B | 0.68909801 |
| 67 | EIF2AK1 | 0.68503881 |
| 68 | MAP3K13 | 0.67279585 |
| 69 | DYRK3 | 0.65843707 |
| 70 | RPS6KB2 | 0.65378994 |
| 71 | CDK19 | 0.61510339 |
| 72 | MAPK7 | 0.60575112 |
| 73 | SIK3 | 0.60370533 |
| 74 | WEE1 | 0.60278955 |
| 75 | MAP3K8 | 0.60102044 |
| 76 | PAK4 | 0.60100580 |
| 77 | MAP3K11 | 0.59047096 |
| 78 | PRKCQ | 0.59021603 |
| 79 | MAP3K12 | 0.58686668 |
| 80 | MAP2K2 | 0.58361257 |
| 81 | SIK1 | 0.56865100 |
| 82 | EIF2AK3 | 0.56523553 |
| 83 | CAMKK2 | 0.56459355 |
| 84 | TAOK1 | 0.55677813 |
| 85 | KSR2 | 0.54742229 |
| 86 | BMPR2 | 0.54606324 |
| 87 | PTK6 | 0.52562327 |
| 88 | PDK1 | 0.50739964 |
| 89 | STK4 | 0.50494169 |
| 90 | CDC42BPA | 0.48641260 |
| 91 | PRKCH | 0.48533163 |
| 92 | ATR | 0.48380781 |
| 93 | SCYL2 | 0.47338556 |
| 94 | HIPK2 | 0.46186972 |
| 95 | JAK2 | 0.45875163 |
| 96 | RPS6KC1 | 0.45873742 |
| 97 | RPS6KL1 | 0.45873742 |
| 98 | MST4 | 0.45308202 |
| 99 | ILK | 0.44106736 |
| 100 | CHUK | 0.43485814 |
| 101 | PDK3 | 0.42246391 |
| 102 | PDK4 | 0.42246391 |
| 103 | IRAK1 | 0.41447749 |
| 104 | DYRK1B | 0.41177570 |
| 105 | RPS6KA6 | 0.41065073 |
| 106 | MAPK11 | 0.40904395 |
| 107 | MAPK4 | 0.40878099 |
| 108 | PDPK1 | 0.40739367 |
| 109 | PIM2 | 0.40053229 |
| 110 | PRKD2 | 0.40049220 |
| 111 | IRAK2 | 0.38002680 |
| 112 | ALK | 0.37259581 |
| 113 | BCKDK | 0.36458131 |
| 114 | MAP2K6 | 0.36060542 |
| 115 | YES1 | 0.35002740 |
| 116 | MAP3K7 | 0.34560990 |
| 117 | STK11 | 0.33247134 |
| 118 | CDK12 | 0.32819071 |
| 119 | MARK2 | 0.32756876 |
| 120 | CDK7 | 0.31000426 |
| 121 | EPHA3 | 0.30273687 |
| 122 | MAPKAPK2 | 0.29772241 |
| 123 | STK16 | 0.28940403 |
| 124 | MAPK3 | 0.28022729 |
| 125 | PIK3CG | 0.25697130 |
| 126 | MAP3K5 | 0.25301589 |
| 127 | RET | 0.25077120 |
| 128 | RAF1 | 0.24677999 |
| 129 | PTK2B | 0.24187984 |
| 130 | PRKCD | 0.24086673 |
| 131 | FYN | 0.23513657 |
| 132 | SRPK1 | 0.23142943 |
| 133 | CDK9 | 0.23080490 |
| 134 | EPHB1 | 0.22220013 |
| 135 | ARAF | 0.21569766 |
| 136 | ABL1 | 0.20081916 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.85756525 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 2.89044297 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 2.85701054 |
| 4 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.65125088 |
| 5 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.48981746 |
| 6 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.45834883 |
| 7 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.44219697 |
| 8 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.39395712 |
| 9 | Measles_Homo sapiens_hsa05162 | 2.20509946 |
| 10 | Mismatch repair_Homo sapiens_hsa03430 | 2.17340030 |
| 11 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.10304606 |
| 12 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.07638003 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.02306761 |
| 14 | Leishmaniasis_Homo sapiens_hsa05140 | 1.90065464 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 1.90038815 |
| 16 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.85271050 |
| 17 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.80263572 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.72527519 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.66436148 |
| 20 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.60117058 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.54424077 |
| 22 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.45373839 |
| 23 | Shigellosis_Homo sapiens_hsa05131 | 1.42108571 |
| 24 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.41011891 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 1.39373701 |
| 26 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.38420207 |
| 27 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.34458202 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.32551401 |
| 29 | Hepatitis B_Homo sapiens_hsa05161 | 1.22085274 |
| 30 | Allograft rejection_Homo sapiens_hsa05330 | 1.20027901 |
| 31 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.19677166 |
| 32 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.18944894 |
| 33 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.16592945 |
| 34 | HTLV-I infection_Homo sapiens_hsa05166 | 1.12989714 |
| 35 | Viral myocarditis_Homo sapiens_hsa05416 | 1.12977287 |
| 36 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.08814649 |
| 37 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.08445327 |
| 38 | RNA transport_Homo sapiens_hsa03013 | 1.08371287 |
| 39 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.07083079 |
| 40 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.06608104 |
| 41 | Influenza A_Homo sapiens_hsa05164 | 1.06070903 |
| 42 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.05623443 |
| 43 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.05269209 |
| 44 | Legionellosis_Homo sapiens_hsa05134 | 1.03113717 |
| 45 | Proteasome_Homo sapiens_hsa03050 | 1.01384457 |
| 46 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.01235179 |
| 47 | Cell cycle_Homo sapiens_hsa04110 | 0.99626056 |
| 48 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.99114319 |
| 49 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.98565741 |
| 50 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.97773931 |
| 51 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.96637827 |
| 52 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.95772434 |
| 53 | Apoptosis_Homo sapiens_hsa04210 | 0.94922718 |
| 54 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.93083330 |
| 55 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.93057150 |
| 56 | Phagosome_Homo sapiens_hsa04145 | 0.91959799 |
| 57 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.90608828 |
| 58 | Colorectal cancer_Homo sapiens_hsa05210 | 0.90060173 |
| 59 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.89147337 |
| 60 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.88964248 |
| 61 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.88584607 |
| 62 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.87406845 |
| 63 | RNA degradation_Homo sapiens_hsa03018 | 0.87106108 |
| 64 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.85849798 |
| 65 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.84653783 |
| 66 | Platelet activation_Homo sapiens_hsa04611 | 0.84610314 |
| 67 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.83077474 |
| 68 | RNA polymerase_Homo sapiens_hsa03020 | 0.80102181 |
| 69 | Thyroid cancer_Homo sapiens_hsa05216 | 0.78972722 |
| 70 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.75484830 |
| 71 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.75096501 |
| 72 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.74996563 |
| 73 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74536681 |
| 74 | Tuberculosis_Homo sapiens_hsa05152 | 0.74360730 |
| 75 | Salmonella infection_Homo sapiens_hsa05132 | 0.70135951 |
| 76 | Basal transcription factors_Homo sapiens_hsa03022 | 0.69089153 |
| 77 | Pertussis_Homo sapiens_hsa05133 | 0.68693939 |
| 78 | Sulfur relay system_Homo sapiens_hsa04122 | 0.68400929 |
| 79 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.67011533 |
| 80 | Asthma_Homo sapiens_hsa05310 | 0.65231791 |
| 81 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.64905986 |
| 82 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.63117040 |
| 83 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.61872113 |
| 84 | Other glycan degradation_Homo sapiens_hsa00511 | 0.61263659 |
| 85 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.61157714 |
| 86 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.60127808 |
| 87 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.60040208 |
| 88 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.57442762 |
| 89 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.56628137 |
| 90 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.54687638 |
| 91 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.53938199 |
| 92 | Hepatitis C_Homo sapiens_hsa05160 | 0.53157980 |
| 93 | Malaria_Homo sapiens_hsa05144 | 0.52692449 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51965453 |
| 95 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.51405253 |
| 96 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.49816566 |
| 97 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.49157317 |
| 98 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.47845780 |
| 99 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.47602720 |
| 100 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.47438816 |
| 101 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.47177320 |
| 102 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.47121835 |
| 103 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44989496 |
| 104 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.43272362 |
| 105 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.43191460 |
| 106 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.42382289 |
| 107 | Endocytosis_Homo sapiens_hsa04144 | 0.42219576 |
| 108 | Lysosome_Homo sapiens_hsa04142 | 0.41232067 |
| 109 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.39886012 |
| 110 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39749362 |
| 111 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.39375506 |
| 112 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.38191156 |
| 113 | Purine metabolism_Homo sapiens_hsa00230 | 0.38036201 |
| 114 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.36458343 |
| 115 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.36350780 |
| 116 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.34333072 |
| 117 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.33907656 |
| 118 | Endometrial cancer_Homo sapiens_hsa05213 | 0.31845721 |
| 119 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.30984341 |
| 120 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.28961912 |
| 121 | Insulin resistance_Homo sapiens_hsa04931 | 0.27909684 |
| 122 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.27530698 |
| 123 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.27181878 |
| 124 | Pathways in cancer_Homo sapiens_hsa05200 | 0.26933779 |
| 125 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.23577755 |
| 126 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.23179163 |
| 127 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.21343795 |
| 128 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.20653000 |
| 129 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.19167575 |
| 130 | Prostate cancer_Homo sapiens_hsa05215 | 0.16073124 |
| 131 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.15254531 |

