LIME1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)9.50310169
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)9.50310169
3negative T cell selection (GO:0043383)8.66686503
4regulation of isotype switching to IgG isotypes (GO:0048302)8.51706424
5negative thymic T cell selection (GO:0045060)8.25865825
6positive T cell selection (GO:0043368)7.99113800
7positive thymic T cell selection (GO:0045059)7.81357240
8thymic T cell selection (GO:0045061)7.24740099
9positive regulation of gamma-delta T cell activation (GO:0046645)7.07711515
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.98417398
11cellular response to interleukin-15 (GO:0071350)6.96117453
12T cell selection (GO:0045058)6.88410585
13interferon-gamma production (GO:0032609)6.66301106
14response to interleukin-15 (GO:0070672)6.61957047
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.28067952
16T cell migration (GO:0072678)6.11718575
17regulation of gamma-delta T cell differentiation (GO:0045586)5.77250445
18* T cell receptor signaling pathway (GO:0050852)5.62657795
19activated T cell proliferation (GO:0050798)5.40789493
20negative regulation of T cell mediated immunity (GO:0002710)5.33955255
21positive regulation of natural killer cell mediated immunity (GO:0002717)5.28883913
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.28883913
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.27294507
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.27294507
25T cell costimulation (GO:0031295)5.27067662
26regulation of gamma-delta T cell activation (GO:0046643)5.22902940
27lymphocyte costimulation (GO:0031294)5.22039391
28regulation of B cell receptor signaling pathway (GO:0050855)5.20030378
29regulation of natural killer cell mediated immunity (GO:0002715)5.13676528
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.13676528
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.11214922
32leukocyte aggregation (GO:0070486)5.01857426
33positive regulation of isotype switching (GO:0045830)4.98149337
34regulation of T cell tolerance induction (GO:0002664)4.78681543
35* antigen receptor-mediated signaling pathway (GO:0050851)4.69568892
36regulation of T cell receptor signaling pathway (GO:0050856)4.68249846
37regulation of isotype switching (GO:0045191)4.56410457
38regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.55802924
39positive regulation of DNA recombination (GO:0045911)4.52238310
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.48863787
41antigen processing and presentation of endogenous antigen (GO:0019883)4.46588905
42positive regulation of alpha-beta T cell proliferation (GO:0046641)4.46031807
43regulation of alpha-beta T cell proliferation (GO:0046640)4.42898408
44negative regulation of lymphocyte mediated immunity (GO:0002707)4.35974180
45positive regulation of B cell mediated immunity (GO:0002714)4.35440553
46positive regulation of immunoglobulin mediated immune response (GO:0002891)4.35440553
47regulation of regulatory T cell differentiation (GO:0045589)4.24112682
48regulation of leukocyte mediated cytotoxicity (GO:0001910)4.23966008
49regulation of immunoglobulin mediated immune response (GO:0002889)4.16590691
50positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.13211011
51positive regulation of granulocyte differentiation (GO:0030854)4.09718233
52tolerance induction (GO:0002507)4.09608223
53detection of bacterium (GO:0016045)4.02593259
54regulation of cell killing (GO:0031341)4.02021559
55regulation of B cell mediated immunity (GO:0002712)3.99949995
56positive regulation of immunoglobulin production (GO:0002639)3.96078035
57positive regulation of cell killing (GO:0031343)3.94258226
58signal complex assembly (GO:0007172)3.91694902
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.91653754
60positive regulation of tolerance induction (GO:0002645)3.87073254
61regulation of B cell differentiation (GO:0045577)3.82486330
62detection of other organism (GO:0098543)3.82023115
63lymphocyte migration (GO:0072676)3.80836948
64T cell differentiation (GO:0030217)3.79974504
65positive regulation of B cell differentiation (GO:0045579)3.77557377
66mast cell activation (GO:0045576)3.75315188
67regulation of immunoglobulin production (GO:0002637)3.74832313
68alpha-beta T cell differentiation (GO:0046632)3.71156880
69negative regulation of phagocytosis (GO:0050765)3.68269487
70regulation of response to tumor cell (GO:0002834)3.67983249
71positive regulation of response to tumor cell (GO:0002836)3.67983249
72positive regulation of immune response to tumor cell (GO:0002839)3.67983249
73regulation of immune response to tumor cell (GO:0002837)3.67983249
74sequestering of actin monomers (GO:0042989)3.64832501
75negative regulation of T cell receptor signaling pathway (GO:0050860)3.63516582
76regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.62191498
77NIK/NF-kappaB signaling (GO:0038061)3.62147565
78negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.59760150
79alpha-beta T cell activation (GO:0046631)3.59181386
80Arp2/3 complex-mediated actin nucleation (GO:0034314)3.59002930
81regulation of response to interferon-gamma (GO:0060330)3.56432048
82negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.51309165
83Peyers patch development (GO:0048541)3.51205113
84mucosal-associated lymphoid tissue development (GO:0048537)3.51205113
85positive regulation by symbiont of host defense response (GO:0052509)3.46364221
86modulation by symbiont of host defense response (GO:0052031)3.46364221
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46364221
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46364221
89positive regulation by organism of defense response of other organism involved in symbiotic interact3.46364221
90modulation by symbiont of host immune response (GO:0052553)3.46364221
91positive regulation of T cell mediated cytotoxicity (GO:0001916)3.45738791
92regulation of defense response to virus by virus (GO:0050690)3.43578973
93cellular response to type I interferon (GO:0071357)3.42840131
94type I interferon signaling pathway (GO:0060337)3.42840131
95regulation of interleukin-12 biosynthetic process (GO:0045075)3.42480569
96immunoglobulin mediated immune response (GO:0016064)3.42424474
97response to type I interferon (GO:0034340)3.41448822
98positive regulation of interleukin-2 production (GO:0032743)3.41196737
99T cell differentiation involved in immune response (GO:0002292)3.40332434
100alpha-beta T cell differentiation involved in immune response (GO:0002293)3.40332434
101alpha-beta T cell activation involved in immune response (GO:0002287)3.40332434
102regulation of T cell mediated cytotoxicity (GO:0001914)3.37710351
103antigen processing and presentation via MHC class Ib (GO:0002475)3.34301028
104T cell activation (GO:0042110)3.34110287
105positive regulation of humoral immune response (GO:0002922)3.31897063
106negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.29752338
107regulation of tolerance induction (GO:0002643)3.27684172
108regulation of lymphocyte mediated immunity (GO:0002706)3.26268717
109respiratory burst (GO:0045730)3.22474419
110positive regulation of T cell differentiation in thymus (GO:0033089)3.21907682
111heterotypic cell-cell adhesion (GO:0034113)3.20882923
112* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.17506379
113natural killer cell activation (GO:0030101)3.17063496
114positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16713472
115positive regulation of lymphocyte mediated immunity (GO:0002708)3.16045487
116negative regulation of adaptive immune response (GO:0002820)3.14413522
117negative regulation of leukocyte mediated immunity (GO:0002704)3.13269433
118positive regulation of calcium-mediated signaling (GO:0050850)3.12364994
119neutrophil activation involved in immune response (GO:0002283)3.09947411
120positive regulation of interleukin-4 production (GO:0032753)3.07578718
121* B cell receptor signaling pathway (GO:0050853)3.05715462
122positive regulation of T cell activation (GO:0050870)3.04839417
123T cell homeostasis (GO:0043029)3.03734213
124leukocyte cell-cell adhesion (GO:0007159)3.02784460
125cellular defense response (GO:0006968)3.00276984
126T-helper cell differentiation (GO:0042093)2.99088186
127CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.99088186
128mast cell activation involved in immune response (GO:0002279)2.98085866
129mast cell degranulation (GO:0043303)2.98085866
130negative regulation of innate immune response (GO:0045824)2.93049891
131detection of external biotic stimulus (GO:0098581)2.86586434
132actin nucleation (GO:0045010)2.85230337
133neutrophil activation (GO:0042119)2.85104688
134negative regulation of T cell apoptotic process (GO:0070233)2.80475133
135negative regulation of erythrocyte differentiation (GO:0045647)2.79203597
136regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78890355
137regulation of alpha-beta T cell activation (GO:0046634)2.78740422
138macrophage activation involved in immune response (GO:0002281)2.78109326
139mature B cell differentiation involved in immune response (GO:0002313)2.77611236
140regulation of interleukin-4 production (GO:0032673)2.76737561
141dendritic cell chemotaxis (GO:0002407)2.74398552
142lymphocyte homeostasis (GO:0002260)2.74228689
143regulation of T cell mediated immunity (GO:0002709)2.73052374
144regulation of granulocyte differentiation (GO:0030852)2.69423031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.89874930
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.59402385
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.16372442
4RUNX_20019798_ChIP-Seq_JUKART_Human4.13539501
5FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse4.02645128
6* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.82632525
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66463714
8* MYB_26560356_Chip-Seq_TH2_Human3.25604057
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22220687
10* MYC_22102868_ChIP-Seq_BL_Human3.08159108
11MAF_26560356_Chip-Seq_TH1_Human3.01361837
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.80437906
13* UTX_26944678_Chip-Seq_JUKART_Human2.78583754
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74170985
15MYB_26560356_Chip-Seq_TH1_Human2.72594920
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.72489502
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44456363
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42713676
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.32416901
20MAF_26560356_Chip-Seq_TH2_Human2.30040618
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20607481
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15404738
23GATA3_27048872_Chip-Seq_THYMUS_Human2.05923598
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98975610
25EZH2_22144423_ChIP-Seq_EOC_Human1.96164701
26* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95129701
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92628000
28* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89574733
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88757100
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.86041983
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84710697
32RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.81693927
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77149953
34BCL6_27268052_Chip-Seq_Bcells_Human1.75042428
35* VDR_21846776_ChIP-Seq_THP-1_Human1.72712475
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69101663
37BCOR_27268052_Chip-Seq_Bcells_Human1.60064031
38TCF7_22412390_ChIP-Seq_EML_Mouse1.59302543
39SPI1_23547873_ChIP-Seq_NB4_Human1.58781859
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58490090
41P68_20966046_ChIP-Seq_HELA_Human1.54927258
42CIITA_25753668_ChIP-Seq_RAJI_Human1.54400973
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.52718831
44KDM2B_26808549_Chip-Seq_DND41_Human1.49491747
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47314770
46* SA1_27219007_Chip-Seq_ERYTHROID_Human1.41227132
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34529956
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29605949
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27820238
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25311109
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25249606
52AR_21572438_ChIP-Seq_LNCaP_Human1.23995186
53* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23090152
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.23012456
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22143823
56* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21659166
57SCL_19346495_ChIP-Seq_HPC-7_Human1.21261050
58* GATA3_26560356_Chip-Seq_TH2_Human1.21077378
59SMC4_20622854_ChIP-Seq_HELA_Human1.20617444
60RACK7_27058665_Chip-Seq_MCF-7_Human1.19976687
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18703735
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18330915
63VDR_24763502_ChIP-Seq_THP-1_Human1.17357576
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.17165242
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16739579
66E2F1_20622854_ChIP-Seq_HELA_Human1.16389391
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14959765
68* TET1_21451524_ChIP-Seq_MESCs_Mouse1.14701815
69* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14331582
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13882841
71SPI1_23127762_ChIP-Seq_K562_Human1.13065516
72CTCF_26484167_Chip-Seq_Bcells_Mouse1.13039189
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11976161
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11339684
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11018671
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10011318
77CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09401613
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09016183
79* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07955588
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06858221
81NCOR1_26117541_ChIP-Seq_K562_Human1.06748346
82P300_27268052_Chip-Seq_Bcells_Human1.06145402
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.05777100
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04248011
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.04159111
86ETS1_21867929_ChIP-Seq_TH2_Mouse1.03918329
87* PHF8_20622854_ChIP-Seq_HELA_Human1.03910603
88* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03899331
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03169558
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01729195
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01401379
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00861208
93VDR_23849224_ChIP-Seq_CD4+_Human1.00733519
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98913653
95FOXP3_21729870_ChIP-Seq_TREG_Human0.97737135
96* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96794766
97RARB_27405468_Chip-Seq_BRAIN_Mouse0.94416108
98* SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.94134409
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.93773760
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91263051
101DROSHA_22980978_ChIP-Seq_HELA_Human0.91019615
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88393516
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87706516
104LXR_22292898_ChIP-Seq_THP-1_Human0.84843250
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84761397
106FLI1_21867929_ChIP-Seq_CD8_Mouse0.84732940
107REST_21632747_ChIP-Seq_MESCs_Mouse0.84378903
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84144959
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.84117364
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83650236
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83628243
112RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82883343
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82575958
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82136865
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81546437
116REST_18959480_ChIP-ChIP_MESCs_Mouse0.80018874
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78881688
118PU_27001747_Chip-Seq_BMDM_Mouse0.78548312
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.76720268
120SA1_27219007_Chip-Seq_Bcells_Human0.74291327
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.74078515
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73171990
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.72789150
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69496509
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.69299092
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68908574
127* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68887492
128ERG_20887958_ChIP-Seq_HPC-7_Mouse0.68316398
129TAF15_26573619_Chip-Seq_HEK293_Human0.67282930
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67058349
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.66013358
132WDR5_24793694_ChIP-Seq_LNCAP_Human0.65228609
133BRD4_27068464_Chip-Seq_AML-cells_Mouse0.64790445
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.63053037
135JARID2_20064375_ChIP-Seq_MESCs_Mouse0.62080430
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61972645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.37019025
2MP0005671_abnormal_response_to5.56966537
3MP0009333_abnormal_splenocyte_physiolog3.20986381
4MP0000685_abnormal_immune_system3.08830265
5MP0001800_abnormal_humoral_immune3.07046836
6MP0001835_abnormal_antigen_presentation2.85090052
7MP0002420_abnormal_adaptive_immunity2.81607545
8MP0001819_abnormal_immune_cell2.76870504
9* MP0002398_abnormal_bone_marrow2.76642289
10MP0002166_altered_tumor_susceptibility2.72938297
11MP0000703_abnormal_thymus_morphology2.72005276
12MP0001790_abnormal_immune_system2.70990321
13MP0005387_immune_system_phenotype2.70990321
14MP0005000_abnormal_immune_tolerance2.67393018
15MP0002723_abnormal_immune_serum2.65871874
16MP0009785_altered_susceptibility_to2.64897655
17MP0001873_stomach_inflammation2.64703809
18MP0006082_CNS_inflammation2.42621061
19* MP0000716_abnormal_immune_system2.35620322
20MP0002452_abnormal_antigen_presenting2.33173859
21MP0002405_respiratory_system_inflammati2.30983784
22MP0002822_catalepsy2.27297527
23MP0002006_tumorigenesis2.25951812
24MP0005025_abnormal_response_to2.23784672
25MP0002722_abnormal_immune_system2.23273464
26MP0000689_abnormal_spleen_morphology2.11706428
27MP0004381_abnormal_hair_follicle2.09556814
28MP0003880_abnormal_central_pattern2.03149250
29MP0003191_abnormal_cellular_cholesterol1.99763103
30MP0003866_abnormal_defecation1.94858834
31* MP0002429_abnormal_blood_cell1.85287935
32MP0001533_abnormal_skeleton_physiology1.82410251
33MP0004859_abnormal_synaptic_plasticity1.80073910
34MP0002396_abnormal_hematopoietic_system1.80006948
35MP0005451_abnormal_body_composition1.74601440
36MP0004510_myositis1.71564050
37MP0005360_urolithiasis1.69960920
38MP0002933_joint_inflammation1.66905012
39MP0010155_abnormal_intestine_physiology1.63283437
40MP0002138_abnormal_hepatobiliary_system1.61593205
41MP0002009_preneoplasia1.51900544
42MP0000858_altered_metastatic_potential1.51426547
43MP0005075_abnormal_melanosome_morpholog1.49283552
44MP0003436_decreased_susceptibility_to1.46690655
45MP0003172_abnormal_lysosome_physiology1.42075650
46MP0002148_abnormal_hypersensitivity_rea1.41440762
47MP0002139_abnormal_hepatobiliary_system1.40929927
48MP0009840_abnormal_foam_cell1.38752657
49MP0004947_skin_inflammation1.37445970
50MP0003724_increased_susceptibility_to1.37048916
51MP0005423_abnormal_somatic_nervous1.36802531
52MP0002419_abnormal_innate_immunity1.34040286
53MP0003787_abnormal_imprinting1.33199982
54MP0008569_lethality_at_weaning1.31884146
55MP0003635_abnormal_synaptic_transmissio1.31306798
56MP0008260_abnormal_autophagy1.30902814
57MP0001845_abnormal_inflammatory_respons1.30012967
58MP0009745_abnormal_behavioral_response1.25929161
59MP0005310_abnormal_salivary_gland1.24988412
60MP0002132_abnormal_respiratory_system1.24645739
61MP0005058_abnormal_lysosome_morphology1.24438832
62MP0009278_abnormal_bone_marrow1.23639303
63MP0009764_decreased_sensitivity_to1.16053900
64MP0005464_abnormal_platelet_physiology1.15948245
65MP0001501_abnormal_sleep_pattern1.14414604
66MP0005365_abnormal_bile_salt1.11728073
67MP0003045_fibrosis1.11407216
68MP0003448_altered_tumor_morphology1.10906209
69MP0003183_abnormal_peptide_metabolism1.06376068
70MP0003806_abnormal_nucleotide_metabolis1.04322824
71MP0000465_gastrointestinal_hemorrhage1.03083190
72MP0001851_eye_inflammation1.01271818
73MP0002277_abnormal_respiratory_mucosa1.00764228
74MP0002572_abnormal_emotion/affect_behav1.00625338
75MP0003300_gastrointestinal_ulcer1.00454626
76MP0002064_seizures0.99888488
77MP0003252_abnormal_bile_duct0.96453495
78MP0005085_abnormal_gallbladder_physiolo0.93619989
79MP0002063_abnormal_learning/memory/cond0.93285147
80MP0002735_abnormal_chemical_nociception0.89941421
81MP0004130_abnormal_muscle_cell0.86681521
82MP0009763_increased_sensitivity_to0.86659456
83MP0001853_heart_inflammation0.85710249
84MP0001348_abnormal_lacrimal_gland0.81501579
85MP0001986_abnormal_taste_sensitivity0.81333216
86MP0004883_abnormal_blood_vessel0.80867926
87MP0010329_abnormal_lipoprotein_level0.78760000
88MP0000609_abnormal_liver_physiology0.78737892
89MP0000604_amyloidosis0.78324041
90MP0001502_abnormal_circadian_rhythm0.78061692
91MP0001968_abnormal_touch/_nociception0.75471906
92MP0002019_abnormal_tumor_incidence0.74042383
93MP0001984_abnormal_olfaction0.74025679
94MP0008961_abnormal_basal_metabolism0.72803657
95MP0003075_altered_response_to0.72749916
96MP0002272_abnormal_nervous_system0.71590686
97MP0008469_abnormal_protein_level0.71478680
98MP0008872_abnormal_physiological_respon0.71339780
99MP0008874_decreased_physiological_sensi0.71287222
100MP0004808_abnormal_hematopoietic_stem0.70556807
101MP0005390_skeleton_phenotype0.70458405
102MP0005166_decreased_susceptibility_to0.68821742
103MP0001529_abnormal_vocalization0.68299015
104MP0002638_abnormal_pupillary_reflex0.66746516
105MP0002163_abnormal_gland_morphology0.66664357
106MP0003690_abnormal_glial_cell0.64855071
107MP0000490_abnormal_crypts_of0.64094374
108MP0004185_abnormal_adipocyte_glucose0.63049508
109MP0006072_abnormal_retinal_apoptosis0.62640744
110MP0003329_amyloid_beta_deposits0.62342465
111MP0001905_abnormal_dopamine_level0.62276350
112MP0009643_abnormal_urine_homeostasis0.62265819
113MP0005377_hearing/vestibular/ear_phenot0.61983926
114MP0003878_abnormal_ear_physiology0.61983926
115MP0005645_abnormal_hypothalamus_physiol0.61800498
116MP0002998_abnormal_bone_remodeling0.61589221
117MP0005397_hematopoietic_system_phenotyp0.60180501
118MP0001545_abnormal_hematopoietic_system0.60180501
119MP0005083_abnormal_biliary_tract0.60136783
120MP0003303_peritoneal_inflammation0.60082289
121MP0002736_abnormal_nociception_after0.59407222
122MP0001970_abnormal_pain_threshold0.59287508
123MP0008877_abnormal_DNA_methylation0.58824913
124MP0002557_abnormal_social/conspecific_i0.58458184
125MP0001764_abnormal_homeostasis0.57991941
126MP0005319_abnormal_enzyme/_coenzyme0.57605203
127MP0005381_digestive/alimentary_phenotyp0.57338941
128MP0009642_abnormal_blood_homeostasis0.57281085
129MP0000249_abnormal_blood_vessel0.56726283
130MP0008875_abnormal_xenobiotic_pharmacok0.55307668
131MP0002184_abnormal_innervation0.53307623
132MP0005499_abnormal_olfactory_system0.53211675
133MP0005394_taste/olfaction_phenotype0.53211675
134MP0002089_abnormal_postnatal_growth/wei0.52692529
135MP0009765_abnormal_xenobiotic_induced0.52560399
136MP0002693_abnormal_pancreas_physiology0.50862482
137MP0006276_abnormal_autonomic_nervous0.49838825
138MP0002083_premature_death0.49388479
139MP0001486_abnormal_startle_reflex0.48263741
140MP0004924_abnormal_behavior0.47501340
141MP0005386_behavior/neurological_phenoty0.47501340
142MP0002733_abnormal_thermal_nociception0.45657854
143MP0001663_abnormal_digestive_system0.44921519

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.58892648
2Abnormality of T cell number (HP:0011839)8.27935032
3Severe combined immunodeficiency (HP:0004430)6.22675831
4Abnormality of T cells (HP:0002843)5.77158236
5Combined immunodeficiency (HP:0005387)5.77048983
6Elevated erythrocyte sedimentation rate (HP:0003565)5.35338107
7Recurrent bronchitis (HP:0002837)5.14120197
8Stomatitis (HP:0010280)4.99210932
9IgG deficiency (HP:0004315)4.73710034
10Increased IgM level (HP:0003496)4.65576588
11Autoimmune hemolytic anemia (HP:0001890)4.59982024
12Abnormality of macrophages (HP:0004311)4.44890381
13Recurrent bacterial skin infections (HP:0005406)4.30001603
14Panhypogammaglobulinemia (HP:0003139)4.29328124
15IgM deficiency (HP:0002850)4.20690202
16Recurrent gram-negative bacterial infections (HP:0005420)4.19001635
17Thyroiditis (HP:0100646)4.05290010
18Nasal polyposis (HP:0100582)4.02062649
19Chronic otitis media (HP:0000389)3.90647739
20Abnormality of eosinophils (HP:0001879)3.86620346
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.84921276
22Recurrent cutaneous fungal infections (HP:0011370)3.83386438
23Chronic mucocutaneous candidiasis (HP:0002728)3.83386438
24Myositis (HP:0100614)3.78564087
25Recurrent fungal infections (HP:0002841)3.73094472
26Lymphopenia (HP:0001888)3.65688810
27Joint swelling (HP:0001386)3.65631205
28Recurrent viral infections (HP:0004429)3.58620796
29Abnormality of B cell number (HP:0010975)3.52905274
30B lymphocytopenia (HP:0010976)3.52905274
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.52564115
32Chronic diarrhea (HP:0002028)3.43481853
33Abnormality of binocular vision (HP:0011514)3.40828057
34Diplopia (HP:0000651)3.40828057
35Abnormality of the fingertips (HP:0001211)3.17268350
36Hypochromic anemia (HP:0001931)3.13006743
37Abnormality of the nasal mucosa (HP:0000433)3.12443183
38Spontaneous hematomas (HP:0007420)3.08792554
39Meningitis (HP:0001287)3.08336794
40Abnormality of T cell physiology (HP:0011840)3.04612147
41Leukocytosis (HP:0001974)3.00545122
42Encephalitis (HP:0002383)2.95594312
43Cellulitis (HP:0100658)2.91225591
44Recurrent sinusitis (HP:0011108)2.88231722
45Chronic sinusitis (HP:0011109)2.87522134
46Hypoplasia of the thymus (HP:0000778)2.86336185
47Purpura (HP:0000979)2.82898554
48Optic neuritis (HP:0100653)2.82563809
49Retrobulbar optic neuritis (HP:0100654)2.82563809
50Hypergammaglobulinemia (HP:0010702)2.81874636
51Hypochromic microcytic anemia (HP:0004840)2.81249589
52Agammaglobulinemia (HP:0004432)2.81013883
53Deep venous thrombosis (HP:0002625)2.80842526
54Gastrointestinal infarctions (HP:0005244)2.80815613
55Mediastinal lymphadenopathy (HP:0100721)2.80738013
56Vasculitis (HP:0002633)2.73483675
57Eosinophilia (HP:0001880)2.70559651
58Bronchitis (HP:0012387)2.70011267
59Hemoptysis (HP:0002105)2.69978145
60Pustule (HP:0200039)2.69694126
61Gastrointestinal inflammation (HP:0004386)2.67459315
62Urticaria (HP:0001025)2.67165389
63Pulmonary infiltrates (HP:0002113)2.66820967
64Colitis (HP:0002583)2.64848581
65Inflammation of the large intestine (HP:0002037)2.64359280
66Lymphoma (HP:0002665)2.64186928
67Gingivitis (HP:0000230)2.59176800
68Joint hemorrhage (HP:0005261)2.55086022
69Basal cell carcinoma (HP:0002671)2.53597561
70Hyperlipoproteinemia (HP:0010980)2.47998366
71Obstructive lung disease (HP:0006536)2.47819035
72Chronic obstructive pulmonary disease (HP:0006510)2.47819035
73Petechiae (HP:0000967)2.44388939
74Sepsis (HP:0100806)2.42977223
75Gingival bleeding (HP:0000225)2.42230202
76Systemic lupus erythematosus (HP:0002725)2.41275415
77Keratoconjunctivitis sicca (HP:0001097)2.38577757
78Abnormality of the prostate (HP:0008775)2.32269875
79Granulocytopenia (HP:0001913)2.31795626
80IgA deficiency (HP:0002720)2.30577135
81Aplastic anemia (HP:0001915)2.29752315
82Slow saccadic eye movements (HP:0000514)2.29739063
83Microcytic anemia (HP:0001935)2.28312475
84Recurrent otitis media (HP:0000403)2.26614623
85Hemorrhage of the eye (HP:0011885)2.25890835
86Verrucae (HP:0200043)2.24959448
87Papilloma (HP:0012740)2.24959448
88Abnormal hair whorl (HP:0010721)2.18201136
89Increased IgE level (HP:0003212)2.15372067
90Keratoconjunctivitis (HP:0001096)2.14184996
91Eczematoid dermatitis (HP:0000976)2.13819960
92Increased serum ferritin (HP:0003281)2.12710396
93Anorexia (HP:0002039)2.12383201
94Episodic fever (HP:0001954)2.10232316
95Acute hepatic failure (HP:0006554)2.09792170
96Orchitis (HP:0100796)2.07527038
97Focal motor seizures (HP:0011153)2.07275287
98Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04654051
99Abnormality of the pleura (HP:0002103)2.04404920
100Gastrointestinal stroma tumor (HP:0100723)2.03933590
101Gangrene (HP:0100758)2.00541798
102Hemiplegia (HP:0002301)1.99499469
103Ureteral stenosis (HP:0000071)1.98512108
104Recurrent pneumonia (HP:0006532)1.97793008
105Acne (HP:0001061)1.96273555
106Autoimmune thrombocytopenia (HP:0001973)1.93766181
107Asplenia (HP:0001746)1.93512189
108Amyotrophic lateral sclerosis (HP:0007354)1.89737374
109Skin ulcer (HP:0200042)1.88244863
110Chest pain (HP:0100749)1.87985937
111Recurrent skin infections (HP:0001581)1.87723758
112Pulmonary embolism (HP:0002204)1.87502537
113Cheilitis (HP:0100825)1.87319471
114Skin rash (HP:0000988)1.86411058
115J-shaped sella turcica (HP:0002680)1.84469575
116Prolonged partial thromboplastin time (HP:0003645)1.84087535
117Febrile seizures (HP:0002373)1.82979559
118Prolonged bleeding time (HP:0003010)1.81980666
119Abnormality of oral frenula (HP:0000190)1.81563244
120Epistaxis (HP:0000421)1.76396363
121Hypoproteinemia (HP:0003075)1.75227031
122Recurrent abscess formation (HP:0002722)1.74762112
123Abnormality of DNA repair (HP:0003254)1.71345648
124Arterial thrombosis (HP:0004420)1.68604836
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.68327631
126Aplasia/Hypoplasia of the thymus (HP:0010515)1.67612264
127Hepatitis (HP:0012115)1.67355707
128Bronchiectasis (HP:0002110)1.66101784
129Abnormality of cells of the erythroid lineage (HP:0012130)1.63970484
130Thrombocytosis (HP:0001894)1.62329728
131Progressive inability to walk (HP:0002505)1.62149675
132Ureteral obstruction (HP:0006000)1.60527873
133Poikiloderma (HP:0001029)1.60322175
134Seborrheic dermatitis (HP:0001051)1.57556235
135Abnormality of secondary sexual hair (HP:0009888)1.57043962
136Abnormality of the axillary hair (HP:0100134)1.57043962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.90947544
2MAP4K15.65695787
3ITK3.61144570
4ZAP703.27361915
5ERN13.00949493
6GRK62.68966314
7JAK32.55347853
8IKBKE2.42015935
9SIK22.27504160
10MAP3K112.26225052
11FGFR42.24991162
12TYK22.19853444
13JAK12.13266776
14MAP3K122.06115377
15TRIB31.94431481
16RIPK11.92242212
17TNK21.88974330
18CLK11.87658326
19* LCK1.87457442
20TAOK31.84316157
21SIK11.74593907
22MST41.73424324
23NLK1.69598631
24SYK1.66633841
25MAP2K31.59602205
26FGFR31.58731760
27CSK1.51972808
28SIK31.47766511
29PRKCH1.43658615
30TBK11.43540050
31TEC1.42765428
32STK101.42264381
33MAP3K141.41732144
34NME21.37087567
35BLK1.36054323
36HCK1.35192205
37CAMKK11.33405879
38EPHB11.29925553
39BTK1.29701955
40FES1.28354285
41TAOK11.24348324
42PRKCQ1.23599974
43SMG11.19519563
44KDR1.19015184
45TESK11.18299112
46PASK1.15212821
47MAP3K131.13450996
48IRAK41.12017399
49CSF1R1.10820279
50MAP3K31.07172279
51TAOK21.03452960
52SCYL21.00368412
53BRD40.98421273
54MARK30.89047092
55MAP3K100.85347258
56MAP3K10.85011903
57NTRK20.84834932
58EPHA40.84404304
59CAMKK20.82994993
60MAP3K70.82577562
61LYN0.82467054
62PRKD20.80548623
63KIT0.78901551
64FGR0.78207442
65FYN0.75851030
66PTK60.75242637
67TNIK0.71024861
68MARK20.70356913
69GRK70.68678070
70PRPF4B0.66265197
71TYRO30.65819782
72PDPK10.64781409
73MAP2K60.61511720
74DAPK10.60139989
75EEF2K0.59619187
76DYRK1A0.56993544
77JAK20.55574159
78TESK20.52756979
79HIPK20.51712035
80IKBKB0.50855560
81DYRK1B0.50005519
82CDC42BPA0.49918855
83ADRBK20.49402137
84IRAK30.45938552
85RPS6KC10.45612840
86RPS6KL10.45612840
87NTRK30.45585546
88MUSK0.45307913
89INSR0.45207664
90BCKDK0.42777778
91LRRK20.42667573
92MAP2K20.42180262
93PDK10.41773543
94MAPK120.40628873
95TSSK60.40542224
96STK380.38224544
97MAPK130.38196694
98RPS6KA60.37705137
99STK110.37465244
100MAPKAPK20.35765802
101MYLK0.34689311
102BMX0.33712773
103IGF1R0.32795874
104CDK40.32656766
105DMPK0.31989482
106UHMK10.31808009
107PIM10.30416098
108MAPK70.29548140
109KSR20.29162495
110MELK0.28584717
111CDK50.28344911
112PRKCB0.28274202
113TLK10.28003188
114CDK190.27779809
115PKN20.27195077
116ICK0.25676083
117MAPK90.25558907
118MAP2K70.24827632
119CHUK0.24057748
120SGK30.24002512
121PRKCI0.23486244
122FGFR10.23170746
123CAMK2B0.22997294
124MAPK110.22478545
125CDK30.22246077
126SGK20.21968142
127CSNK1A1L0.20614102
128IRAK20.20520437
129MAPK40.20484325
130RIPK40.19967108
131SRC0.19361695
132BMPR20.17996775
133MAPK80.16706118
134PRKCD0.16414902
135CDK11A0.16409384
136MAPK30.16378874

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.88179148
2Graft-versus-host disease_Homo sapiens_hsa053324.74342132
3T cell receptor signaling pathway_Homo sapiens_hsa046603.91604908
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.68323120
5Allograft rejection_Homo sapiens_hsa053303.39114787
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.09991806
7Antigen processing and presentation_Homo sapiens_hsa046122.62466239
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.50099071
9Staphylococcus aureus infection_Homo sapiens_hsa051502.43373226
10Measles_Homo sapiens_hsa051622.38479035
11Autoimmune thyroid disease_Homo sapiens_hsa053202.28211037
12Hematopoietic cell lineage_Homo sapiens_hsa046401.97620603
13Type I diabetes mellitus_Homo sapiens_hsa049401.81067948
14Other glycan degradation_Homo sapiens_hsa005111.71772966
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.70736048
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.65666785
17Ribosome_Homo sapiens_hsa030101.62783116
18Nicotine addiction_Homo sapiens_hsa050331.58198852
19Viral myocarditis_Homo sapiens_hsa054161.56462681
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.39564839
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38959568
22B cell receptor signaling pathway_Homo sapiens_hsa046621.30598962
23Osteoclast differentiation_Homo sapiens_hsa043801.27190794
24Leishmaniasis_Homo sapiens_hsa051401.20531284
25Complement and coagulation cascades_Homo sapiens_hsa046101.18950026
26Asthma_Homo sapiens_hsa053101.17261009
27Chemokine signaling pathway_Homo sapiens_hsa040621.15165548
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11658286
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10080339
30Herpes simplex infection_Homo sapiens_hsa051681.07095376
31Long-term potentiation_Homo sapiens_hsa047201.05886316
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04135673
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02110025
34Pertussis_Homo sapiens_hsa051331.00075124
35Morphine addiction_Homo sapiens_hsa050320.98201478
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93323438
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91386195
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89091290
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85066398
40Olfactory transduction_Homo sapiens_hsa047400.84420077
41Non-homologous end-joining_Homo sapiens_hsa034500.80568834
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.80199243
43Amphetamine addiction_Homo sapiens_hsa050310.79634366
44HTLV-I infection_Homo sapiens_hsa051660.78045532
45Hepatitis B_Homo sapiens_hsa051610.77966391
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.72723552
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68534847
48Glutamatergic synapse_Homo sapiens_hsa047240.67734820
49Circadian entrainment_Homo sapiens_hsa047130.66491130
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.64293688
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.64059792
52Shigellosis_Homo sapiens_hsa051310.63327246
53Colorectal cancer_Homo sapiens_hsa052100.62768049
54Spliceosome_Homo sapiens_hsa030400.61904062
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.61666198
56Insulin resistance_Homo sapiens_hsa049310.61528553
57Influenza A_Homo sapiens_hsa051640.61246210
58Toxoplasmosis_Homo sapiens_hsa051450.61012286
59Dopaminergic synapse_Homo sapiens_hsa047280.59553690
60Acute myeloid leukemia_Homo sapiens_hsa052210.59540797
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59430833
62Legionellosis_Homo sapiens_hsa051340.59240912
63Chronic myeloid leukemia_Homo sapiens_hsa052200.58771139
64Caffeine metabolism_Homo sapiens_hsa002320.56891341
65Viral carcinogenesis_Homo sapiens_hsa052030.56878755
66VEGF signaling pathway_Homo sapiens_hsa043700.56816686
67GABAergic synapse_Homo sapiens_hsa047270.56230436
68Choline metabolism in cancer_Homo sapiens_hsa052310.55241296
69Phagosome_Homo sapiens_hsa041450.54915446
70Calcium signaling pathway_Homo sapiens_hsa040200.54814308
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54343754
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54216490
73Oxytocin signaling pathway_Homo sapiens_hsa049210.53460698
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53348555
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52954982
76Platelet activation_Homo sapiens_hsa046110.50652811
77Rheumatoid arthritis_Homo sapiens_hsa053230.50214464
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50099155
79Salivary secretion_Homo sapiens_hsa049700.49850565
80Sulfur relay system_Homo sapiens_hsa041220.49216166
81Prion diseases_Homo sapiens_hsa050200.49093728
82Gastric acid secretion_Homo sapiens_hsa049710.48855309
83ABC transporters_Homo sapiens_hsa020100.48778172
84Taste transduction_Homo sapiens_hsa047420.48766925
85cAMP signaling pathway_Homo sapiens_hsa040240.48248021
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47709442
87Renin secretion_Homo sapiens_hsa049240.47524425
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47070897
89Cholinergic synapse_Homo sapiens_hsa047250.46973703
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46641738
91MAPK signaling pathway_Homo sapiens_hsa040100.46441345
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.45933070
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45603644
94mTOR signaling pathway_Homo sapiens_hsa041500.45493393
95Linoleic acid metabolism_Homo sapiens_hsa005910.44847758
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44831298
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.44656421
98mRNA surveillance pathway_Homo sapiens_hsa030150.44496330
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42744581
100Cocaine addiction_Homo sapiens_hsa050300.41963229
101Regulation of autophagy_Homo sapiens_hsa041400.41782384
102Apoptosis_Homo sapiens_hsa042100.41246299
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.41231283
104Epstein-Barr virus infection_Homo sapiens_hsa051690.40932399
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40708390
106Pancreatic cancer_Homo sapiens_hsa052120.40679855
107Endocytosis_Homo sapiens_hsa041440.39793731
108Retinol metabolism_Homo sapiens_hsa008300.39718185
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39623471
110TNF signaling pathway_Homo sapiens_hsa046680.38051133
111Hepatitis C_Homo sapiens_hsa051600.37271561
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35754922
113Arachidonic acid metabolism_Homo sapiens_hsa005900.35240058
114Chemical carcinogenesis_Homo sapiens_hsa052040.34794694
115Malaria_Homo sapiens_hsa051440.34721177
116Rap1 signaling pathway_Homo sapiens_hsa040150.34706719
117Salmonella infection_Homo sapiens_hsa051320.34529443
118Non-small cell lung cancer_Homo sapiens_hsa052230.34442856
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33991570
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32922199
121Tuberculosis_Homo sapiens_hsa051520.32897448
122Insulin secretion_Homo sapiens_hsa049110.32242293
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.32024686
124African trypanosomiasis_Homo sapiens_hsa051430.31876469
125Tyrosine metabolism_Homo sapiens_hsa003500.31228190
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.30532954
127RNA degradation_Homo sapiens_hsa030180.29476147
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28870800
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27324659
130Prolactin signaling pathway_Homo sapiens_hsa049170.27062076
131Notch signaling pathway_Homo sapiens_hsa043300.26738566
132FoxO signaling pathway_Homo sapiens_hsa040680.26666430
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25927070
134Lysosome_Homo sapiens_hsa041420.25864323
135Inositol phosphate metabolism_Homo sapiens_hsa005620.25770964
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25310058
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24484838
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24459283
139Serotonergic synapse_Homo sapiens_hsa047260.23609333

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