LIMK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.98368796
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30528494
3layer formation in cerebral cortex (GO:0021819)5.27125739
4locomotory exploration behavior (GO:0035641)5.23443326
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.97443571
6glutamate secretion (GO:0014047)4.38628037
7sodium ion export (GO:0071436)4.36560229
8regulation of synaptic vesicle exocytosis (GO:2000300)4.33842975
9synaptic vesicle exocytosis (GO:0016079)4.31702068
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30844128
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.19339015
12protein localization to endosome (GO:0036010)4.17299872
13glycine transport (GO:0015816)4.16226639
14vocalization behavior (GO:0071625)4.13180935
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.05613092
16proline transport (GO:0015824)4.05378309
17exploration behavior (GO:0035640)4.05261787
18cell migration in hindbrain (GO:0021535)4.04907131
19regulation of early endosome to late endosome transport (GO:2000641)3.98434055
20protein localization to synapse (GO:0035418)3.97252763
21cytoskeletal anchoring at plasma membrane (GO:0007016)3.90496445
22negative regulation of microtubule polymerization (GO:0031115)3.83229817
23cellular potassium ion homeostasis (GO:0030007)3.74815803
24regulation of glutamate receptor signaling pathway (GO:1900449)3.73384685
25dendritic spine morphogenesis (GO:0060997)3.73371529
26regulation of synaptic vesicle transport (GO:1902803)3.68071548
27neurotransmitter secretion (GO:0007269)3.66939281
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.63730156
29barbed-end actin filament capping (GO:0051016)3.60164659
30positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.54299676
31amino acid import (GO:0043090)3.50511309
32neuromuscular process controlling balance (GO:0050885)3.48133351
33virion attachment to host cell (GO:0019062)3.43378354
34adhesion of symbiont to host cell (GO:0044650)3.43378354
35activation of protein kinase A activity (GO:0034199)3.42513216
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40289648
37cerebellar Purkinje cell differentiation (GO:0021702)3.40211147
38cell communication by electrical coupling (GO:0010644)3.39283125
39axon cargo transport (GO:0008088)3.37829793
40neuronal action potential propagation (GO:0019227)3.37157561
41neuron cell-cell adhesion (GO:0007158)3.36464036
42regulation of synapse structural plasticity (GO:0051823)3.34709476
43regulation of neuronal synaptic plasticity (GO:0048168)3.29524372
44negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27608001
45dendrite morphogenesis (GO:0048813)3.26523937
46cell-cell junction maintenance (GO:0045217)3.25562664
47semaphorin-plexin signaling pathway (GO:0071526)3.24026144
48regulation of ARF protein signal transduction (GO:0032012)3.21601072
49adhesion of symbiont to host (GO:0044406)3.20892471
50gamma-aminobutyric acid transport (GO:0015812)3.20355582
51apoptotic cell clearance (GO:0043277)3.20224954
52positive regulation of protein dephosphorylation (GO:0035307)3.15953723
53stress fiber assembly (GO:0043149)3.15448623
54neuromuscular process controlling posture (GO:0050884)3.14313283
55establishment of nucleus localization (GO:0040023)3.13895886
56mannose metabolic process (GO:0006013)3.12096551
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11215715
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.08045082
59synaptic vesicle endocytosis (GO:0048488)3.06611484
60regulation of clathrin-mediated endocytosis (GO:2000369)3.04333927
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03587451
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02584959
63membrane depolarization during action potential (GO:0086010)3.02057788
64neuron recognition (GO:0008038)2.99295524
65glycosphingolipid catabolic process (GO:0046479)2.98620040
66positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96488164
67axonal fasciculation (GO:0007413)2.93834533
68regulation of NFAT protein import into nucleus (GO:0051532)2.90735642
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88610556
70regulation of ARF GTPase activity (GO:0032312)2.88043248
71positive regulation of synapse maturation (GO:0090129)2.87286805
72clathrin coat assembly (GO:0048268)2.84795641
73neurotransmitter transport (GO:0006836)2.83972983
74cerebellar Purkinje cell layer development (GO:0021680)2.83745836
75neuronal ion channel clustering (GO:0045161)2.83735049
76amino sugar catabolic process (GO:0046348)2.82393642
77positive regulation of fibroblast migration (GO:0010763)2.81534221
78potassium ion import (GO:0010107)2.80991547
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79990576
80regulation of leukocyte degranulation (GO:0043300)2.79887788
81cortical actin cytoskeleton organization (GO:0030866)2.79775018
82alanine transport (GO:0032328)2.79568973
83regulation of translational termination (GO:0006449)2.78492447
84organelle transport along microtubule (GO:0072384)2.77902210
85adenosine receptor signaling pathway (GO:0001973)2.77293844
86neurofilament cytoskeleton organization (GO:0060052)2.76763697
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76080708
88vesicle transport along microtubule (GO:0047496)2.75992971
89axon extension (GO:0048675)2.72052245
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69769013
91positive regulation of membrane potential (GO:0045838)2.69603380
92peptidyl-lysine dimethylation (GO:0018027)2.68836188
93neuromuscular process (GO:0050905)2.67092621
94response to auditory stimulus (GO:0010996)2.66733311
95regulation of regulated secretory pathway (GO:1903305)2.64955974
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63263494
97mitochondrion transport along microtubule (GO:0047497)2.63263494
98regulation of neurotransmitter levels (GO:0001505)2.61749045
99regulation of neurotransmitter secretion (GO:0046928)2.61663775
100innervation (GO:0060384)2.61360914
101signal complex assembly (GO:0007172)2.60869231
102negative regulation of cell size (GO:0045792)2.59901167
103synaptic transmission, glutamatergic (GO:0035249)2.59843124
104* regulation of axon extension (GO:0030516)2.59422731
105postsynaptic membrane organization (GO:0001941)2.58626975
106nerve growth factor signaling pathway (GO:0038180)2.57415194
107cerebellum development (GO:0021549)2.57340986
108glycolipid catabolic process (GO:0019377)2.56784761
109modulation by symbiont of host cellular process (GO:0044068)2.55944869
110potassium ion homeostasis (GO:0055075)2.55299100
111* positive regulation of axon extension (GO:0045773)2.55202676
112L-amino acid import (GO:0043092)2.54302569
113negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.54051315
114cellular sodium ion homeostasis (GO:0006883)2.53442947
115response to acidic pH (GO:0010447)2.53002811
116activation of Rac GTPase activity (GO:0032863)2.52812379
117ceramide catabolic process (GO:0046514)2.52511239
118regulation of mast cell degranulation (GO:0043304)2.52149292
119dendritic spine organization (GO:0097061)2.52140477
120detection of temperature stimulus (GO:0016048)2.50487505
121* regulation of axonogenesis (GO:0050770)2.49692349
122response to peptidoglycan (GO:0032494)2.49238947
123cortical cytoskeleton organization (GO:0030865)2.49072663
124membrane repolarization (GO:0086009)2.49045948
125long-term memory (GO:0007616)2.48139105
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47831956
127positive regulation of potassium ion transmembrane transport (GO:1901381)2.47373042
128glutamate receptor signaling pathway (GO:0007215)2.47353359
129regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46649948
130plasma membrane repair (GO:0001778)2.46646030
131endodermal cell differentiation (GO:0035987)2.46508209
132dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45561871
133detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.45437883
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.44734958
135negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44119019
136regulation of cholesterol storage (GO:0010885)2.40977120
137tooth mineralization (GO:0034505)2.40732344
138positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39829805
139regulation of defense response to virus by virus (GO:0050690)2.36868203
140decidualization (GO:0046697)2.35291946
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33267864
142regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32576035
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.31417548
144positive regulation of neurotransmitter secretion (GO:0001956)2.31193763
145activation of MAPKKK activity (GO:0000185)2.30436175
146negative regulation of interleukin-12 production (GO:0032695)2.30368164
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30030791
148negative regulation of cell killing (GO:0031342)2.30030791
149negative regulation of macroautophagy (GO:0016242)2.29947748
150glial cell migration (GO:0008347)2.29913020
151positive regulation of macrophage cytokine production (GO:0060907)2.28272216
152substrate-dependent cell migration (GO:0006929)2.28067253
153skin morphogenesis (GO:0043589)2.26616250
154vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24396441
155negative regulation of adherens junction organization (GO:1903392)2.23887288
156negative regulation of focal adhesion assembly (GO:0051895)2.23887288
157negative regulation of cell junction assembly (GO:1901889)2.23887288
158regulation of synaptic plasticity (GO:0048167)2.23267988
159cellular response to thyroid hormone stimulus (GO:0097067)2.23039590
160regulation of protein dephosphorylation (GO:0035304)2.22767819
161positive regulation of neurotransmitter transport (GO:0051590)2.22713298
162regulation of mast cell activation involved in immune response (GO:0033006)2.20955408
163positive regulation of leukocyte degranulation (GO:0043302)2.19763427
164regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19660155
165negative regulation of Ras protein signal transduction (GO:0046580)2.19230520
166cell junction maintenance (GO:0034331)2.18770244
167response to muramyl dipeptide (GO:0032495)2.18636273
168macrophage activation involved in immune response (GO:0002281)2.18465025
169ganglioside metabolic process (GO:0001573)2.18358051
170actin filament bundle assembly (GO:0051017)2.18202840
171actin filament bundle organization (GO:0061572)2.18202840
172negative regulation of mast cell activation (GO:0033004)2.17478783
173adherens junction assembly (GO:0034333)2.16223141
174positive regulation of dendritic spine development (GO:0060999)2.15579150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17799592
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.41399389
3IKZF1_21737484_ChIP-ChIP_HCT116_Human2.58235366
4DROSHA_22980978_ChIP-Seq_HELA_Human2.53494252
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52433148
6* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.50157076
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46206501
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45347948
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.39460643
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38502506
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36498600
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33593470
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33593470
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31459698
15KDM2B_26808549_Chip-Seq_K562_Human2.30298489
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22572280
17REST_21632747_ChIP-Seq_MESCs_Mouse2.21920082
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17450107
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17089871
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15048277
21ZFP281_27345836_Chip-Seq_ESCs_Mouse2.11383901
22KDM2B_26808549_Chip-Seq_DND41_Human2.10764190
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10404152
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06164065
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.01616868
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01349752
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93353514
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93110551
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.91835712
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.91573785
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.90317111
32* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89087136
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88688539
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.88123065
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86913754
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84143773
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80902888
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80319740
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80175277
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77714999
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.71902484
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65546988
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62389452
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61326605
45* LXR_22292898_ChIP-Seq_THP-1_Human1.58875522
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58310653
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54319486
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53028849
49* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51893446
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51654116
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51507022
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50807767
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.50034335
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.48984482
55* MYC_22102868_ChIP-Seq_BL_Human1.45360664
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44738613
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44376540
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.40885787
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40831365
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39994954
61* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39552146
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37263671
63* VDR_24763502_ChIP-Seq_THP-1_Human1.35963157
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.35840745
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35371665
66GBX2_23144817_ChIP-Seq_PC3_Human1.34684438
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34475037
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31394160
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31249136
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.31060683
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30199747
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27096902
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.26416180
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23428660
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22652983
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22403087
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21258605
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20920252
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.20883042
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.19151759
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.19120808
82AR_21572438_ChIP-Seq_LNCaP_Human1.18760301
83AR_19668381_ChIP-Seq_PC3_Human1.16479017
84CTCF_27219007_Chip-Seq_Bcells_Human1.16386475
85TP53_23651856_ChIP-Seq_MEFs_Mouse1.16066014
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.15653707
87* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12214517
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11910869
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11591489
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11490360
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.10539209
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.10292312
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09926408
94BCOR_27268052_Chip-Seq_Bcells_Human1.08288119
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.08053007
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07832253
97* SMC4_20622854_ChIP-Seq_HELA_Human1.06560820
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06522942
99CREB1_26743006_Chip-Seq_LNCaP_Human1.05010767
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04874153
101BCL6_27268052_Chip-Seq_Bcells_Human1.04324377
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04030674
103VDR_21846776_ChIP-Seq_THP-1_Human1.03572632
104ZNF274_21170338_ChIP-Seq_K562_Hela1.03204594
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.00957754
106SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00948990
107* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00590545
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99614742
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99235521
110TP63_22573176_ChIP-Seq_HFKS_Human0.99038670
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99037990
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98615261
113SPI1_23127762_ChIP-Seq_K562_Human0.97452995
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.96862335
115* OCT4_19829295_ChIP-Seq_ESCs_Human0.96191782
116ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95861841
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.94508818
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93740790
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.92735226
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91503161
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91061872
122* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90895217
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90068210
124* KLF4_19829295_ChIP-Seq_ESCs_Human0.89199013
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88024999
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.87196156
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87149891
128TP53_22127205_ChIP-Seq_IMR90_Human0.86761808
129RACK7_27058665_Chip-Seq_MCF-7_Human0.86436271
130* P68_20966046_ChIP-Seq_HELA_Human0.83477388
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.82882782
132SMAD4_21741376_ChIP-Seq_ESCs_Human0.80743992
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78817531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.99430742
2MP0005058_abnormal_lysosome_morphology3.84527687
3* MP0003635_abnormal_synaptic_transmissio3.42520518
4MP0001968_abnormal_touch/_nociception3.40750588
5MP0004858_abnormal_nervous_system3.25613529
6MP0003880_abnormal_central_pattern3.23797844
7MP0004270_analgesia3.02742699
8MP0009840_abnormal_foam_cell3.01881376
9MP0005423_abnormal_somatic_nervous2.82279500
10MP0002736_abnormal_nociception_after2.70800106
11MP0002733_abnormal_thermal_nociception2.59253769
12MP0002735_abnormal_chemical_nociception2.57731710
13* MP0002063_abnormal_learning/memory/cond2.54977016
14MP0005257_abnormal_intraocular_pressure2.51702907
15MP0002734_abnormal_mechanical_nocicepti2.41245619
16MP0006276_abnormal_autonomic_nervous2.41190205
17MP0009046_muscle_twitch2.40570380
18MP0002064_seizures2.35640551
19MP0009745_abnormal_behavioral_response2.29507958
20MP0001970_abnormal_pain_threshold2.17679995
21MP0000569_abnormal_digit_pigmentation2.16941515
22MP0003279_aneurysm2.08128870
23MP0003436_decreased_susceptibility_to2.03257722
24MP0004811_abnormal_neuron_physiology2.02295422
25MP0002184_abnormal_innervation2.02282481
26MP0005623_abnormal_meninges_morphology2.00788380
27MP0002572_abnormal_emotion/affect_behav1.99248663
28MP0002254_reproductive_system_inflammat1.94626732
29MP0002877_abnormal_melanocyte_morpholog1.90011357
30MP0002998_abnormal_bone_remodeling1.89874973
31MP0001486_abnormal_startle_reflex1.89402376
32MP0006082_CNS_inflammation1.86385031
33MP0009780_abnormal_chondrocyte_physiolo1.86168324
34MP0000955_abnormal_spinal_cord1.84337777
35MP0008438_abnormal_cutaneous_collagen1.82278678
36MP0003300_gastrointestinal_ulcer1.80248841
37MP0001348_abnormal_lacrimal_gland1.80200671
38MP0002272_abnormal_nervous_system1.80037908
39MP0000778_abnormal_nervous_system1.76317685
40MP0003787_abnormal_imprinting1.75161772
41MP0008569_lethality_at_weaning1.70174319
42MP0000343_altered_response_to1.69583339
43MP0002067_abnormal_sensory_capabilities1.66479682
44MP0003329_amyloid_beta_deposits1.65359852
45MP0004885_abnormal_endolymph1.65171975
46MP0003123_paternal_imprinting1.63738159
47MP0002909_abnormal_adrenal_gland1.57074880
48MP0002419_abnormal_innate_immunity1.53533728
49MP0003566_abnormal_cell_adhesion1.46379578
50MP0008961_abnormal_basal_metabolism1.44100433
51MP0001440_abnormal_grooming_behavior1.43106057
52MP0002148_abnormal_hypersensitivity_rea1.42181116
53MP0003303_peritoneal_inflammation1.41126878
54MP0003283_abnormal_digestive_organ1.40354434
55MP0001533_abnormal_skeleton_physiology1.39843524
56MP0002882_abnormal_neuron_morphology1.39185582
57MP0003122_maternal_imprinting1.38041294
58MP0002557_abnormal_social/conspecific_i1.31405281
59MP0004947_skin_inflammation1.28005259
60MP0003191_abnormal_cellular_cholesterol1.24478467
61MP0005451_abnormal_body_composition1.24397989
62MP0005167_abnormal_blood-brain_barrier1.23972280
63* MP0002066_abnormal_motor_capabilities/c1.22922369
64MP0001501_abnormal_sleep_pattern1.22741332
65MP0003705_abnormal_hypodermis_morpholog1.20271319
66* MP0002152_abnormal_brain_morphology1.19545534
67MP0003633_abnormal_nervous_system1.18773136
68MP0005000_abnormal_immune_tolerance1.18552757
69MP0000751_myopathy1.17921085
70MP0005671_abnormal_response_to1.16185600
71MP0000685_abnormal_immune_system1.14790955
72MP0005595_abnormal_vascular_smooth1.13589471
73MP0001299_abnormal_eye_distance/1.13115702
74MP0003172_abnormal_lysosome_physiology1.12652492
75MP0004142_abnormal_muscle_tone1.11727677
76MP0003879_abnormal_hair_cell1.11436259
77MP0003453_abnormal_keratinocyte_physiol1.09453995
78MP0005387_immune_system_phenotype1.09054081
79MP0001790_abnormal_immune_system1.09054081
80MP0004510_myositis1.08231429
81MP0003183_abnormal_peptide_metabolism1.07526462
82MP0005390_skeleton_phenotype1.07377135
83MP0005076_abnormal_cell_differentiation1.07250980
84MP0003634_abnormal_glial_cell1.05338744
85MP0001502_abnormal_circadian_rhythm1.02758404
86MP0003448_altered_tumor_morphology1.02558060
87MP0000858_altered_metastatic_potential1.01898365
88MP0003861_abnormal_nervous_system1.00931915
89MP0004924_abnormal_behavior1.00025043
90MP0005386_behavior/neurological_phenoty1.00025043
91MP0001542_abnormal_bone_strength0.99574651
92MP0002452_abnormal_antigen_presenting0.96951439
93MP0003631_nervous_system_phenotype0.96099244
94MP0002653_abnormal_ependyma_morphology0.95205491
95MP0003121_genomic_imprinting0.95041889
96MP0005023_abnormal_wound_healing0.94776447
97MP0005025_abnormal_response_to0.94135746
98MP0003137_abnormal_impulse_conducting0.93469033
99MP0002896_abnormal_bone_mineralization0.93335579
100MP0005508_abnormal_skeleton_morphology0.91773555
101MP0000767_abnormal_smooth_muscle0.90168396
102MP0003045_fibrosis0.90063259
103MP0004233_abnormal_muscle_weight0.88974499
104MP0003385_abnormal_body_wall0.86915140
105MP0000534_abnormal_ureter_morphology0.85979055
106MP0001849_ear_inflammation0.85272476
107MP0005464_abnormal_platelet_physiology0.84462776
108MP0000678_abnormal_parathyroid_gland0.83211596
109MP0002723_abnormal_immune_serum0.81008608
110MP0005310_abnormal_salivary_gland0.80819896
111MP0003091_abnormal_cell_migration0.80810331
112MP0003690_abnormal_glial_cell0.79894267
113MP0002089_abnormal_postnatal_growth/wei0.78505071
114MP0001835_abnormal_antigen_presentation0.78477653
115MP0000015_abnormal_ear_pigmentation0.76485325
116MP0001958_emphysema0.75446067
117MP0008874_decreased_physiological_sensi0.75275411
118MP0000371_diluted_coat_color0.75242363
119MP0008770_decreased_survivor_rate0.73649354
120MP0004085_abnormal_heartbeat0.72949505
121MP0001853_heart_inflammation0.72301167
122MP0001819_abnormal_immune_cell0.71846840
123MP0002420_abnormal_adaptive_immunity0.71765183
124MP0005166_decreased_susceptibility_to0.71581621
125MP0005409_darkened_coat_color0.71542760
126MP0002752_abnormal_somatic_nervous0.70750923
127MP0003795_abnormal_bone_structure0.70591234
128MP0009278_abnormal_bone_marrow0.70459549
129MP0003632_abnormal_nervous_system0.70015002
130MP0002249_abnormal_larynx_morphology0.69677214
131MP0000604_amyloidosis0.69577572
132MP0002113_abnormal_skeleton_development0.69064816
133MP0003075_altered_response_to0.67570469
134MP0002229_neurodegeneration0.67512396
135MP0000747_muscle_weakness0.67045988
136MP0000920_abnormal_myelination0.66815988
137MP0010769_abnormal_survival0.64987889
138MP0002751_abnormal_autonomic_nervous0.64443929
139MP0004130_abnormal_muscle_cell0.63583314
140MP0002081_perinatal_lethality0.63394888
141MP0010768_mortality/aging0.61115475
142MP0001943_abnormal_respiration0.61029979
143MP0010770_preweaning_lethality0.60816335
144MP0002082_postnatal_lethality0.60816335
145MP0004145_abnormal_muscle_electrophysio0.59370445
146MP0005645_abnormal_hypothalamus_physiol0.58574778
147MP0000428_abnormal_craniofacial_morphol0.57803440
148MP0008877_abnormal_DNA_methylation0.54945653
149MP0002069_abnormal_eating/drinking_beha0.53195851
150MP0005394_taste/olfaction_phenotype0.53093533
151MP0005499_abnormal_olfactory_system0.53093533
152MP0001485_abnormal_pinna_reflex0.53008228
153MP0003119_abnormal_digestive_system0.52643827

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.57229406
2Abnormality of liposaccharide metabolism (HP:0010968)5.57229406
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.57229406
4Abnormality of the lower motor neuron (HP:0002366)4.78652861
5Increased cerebral lipofuscin (HP:0011813)4.65219928
6Myokymia (HP:0002411)4.62405708
7Neurofibrillary tangles (HP:0002185)4.32123448
8Supranuclear gaze palsy (HP:0000605)4.18855237
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.13544341
10Focal seizures (HP:0007359)3.66647141
11* Hyperacusis (HP:0010780)3.63152220
12Amyotrophic lateral sclerosis (HP:0007354)3.59992844
13Dysostosis multiplex (HP:0000943)3.59428008
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.53141023
15Ankle clonus (HP:0011448)3.52508980
16Visual hallucinations (HP:0002367)3.41859967
17* Insomnia (HP:0100785)3.20470924
18Termporal pattern (HP:0011008)3.20055806
19Insidious onset (HP:0003587)3.20055806
20Action tremor (HP:0002345)3.13596100
21Urinary urgency (HP:0000012)3.10490308
22Vacuolated lymphocytes (HP:0001922)3.05146233
23Urinary bladder sphincter dysfunction (HP:0002839)2.99571539
24Focal motor seizures (HP:0011153)2.97176855
25Mutism (HP:0002300)2.94776700
26Loss of speech (HP:0002371)2.92244835
27Vertebral compression fractures (HP:0002953)2.85461878
28Premature rupture of membranes (HP:0001788)2.79798230
29Abnormality of polysaccharide metabolism (HP:0011012)2.78430705
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78430705
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78430705
32Ankle contracture (HP:0006466)2.76243523
33Papilledema (HP:0001085)2.72387773
34Axonal loss (HP:0003447)2.70406734
35Urinary glycosaminoglycan excretion (HP:0003541)2.69872339
36Mucopolysacchariduria (HP:0008155)2.69872339
37Apathy (HP:0000741)2.67099327
38Protrusio acetabuli (HP:0003179)2.66885632
39* Pointed chin (HP:0000307)2.64631654
40Nuclear cataract (HP:0100018)2.62599517
41Atonic seizures (HP:0010819)2.57441811
42Impaired vibration sensation in the lower limbs (HP:0002166)2.57205582
43Abnormality of macrophages (HP:0004311)2.55554164
44* Elfin facies (HP:0004428)2.48107433
45Spastic gait (HP:0002064)2.44306659
46Ulnar claw (HP:0001178)2.43984209
47* Overriding aorta (HP:0002623)2.43463475
48Diminished motivation (HP:0000745)2.42166226
49Annular pancreas (HP:0001734)2.42021564
50J-shaped sella turcica (HP:0002680)2.41976095
51Lower limb amyotrophy (HP:0007210)2.40667735
52Upper motor neuron abnormality (HP:0002127)2.39964369
53Hemiplegia (HP:0002301)2.39920130
54Progressive cerebellar ataxia (HP:0002073)2.36821164
55Cervical subluxation (HP:0003308)2.34284233
56* Renal duplication (HP:0000075)2.33574383
57Febrile seizures (HP:0002373)2.32903643
58Depression (HP:0000716)2.32684314
59Cerebral aneurysm (HP:0004944)2.31007571
60Shallow orbits (HP:0000586)2.29931404
61Generalized tonic-clonic seizures (HP:0002069)2.29296642
62Macroorchidism (HP:0000053)2.27018827
63Hypoventilation (HP:0002791)2.26259839
64Aqueductal stenosis (HP:0002410)2.24376600
65* Renovascular hypertension (HP:0100817)2.23495493
66Upper limb amyotrophy (HP:0009129)2.21554641
67Distal upper limb amyotrophy (HP:0007149)2.21554641
68Genetic anticipation (HP:0003743)2.20966565
69Neoplasm of the heart (HP:0100544)2.20495918
70Turricephaly (HP:0000262)2.20282859
71Broad metatarsal (HP:0001783)2.20173763
72Hand muscle atrophy (HP:0009130)2.19906240
73Enlarged penis (HP:0000040)2.17102936
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16218497
75* Bowel diverticulosis (HP:0005222)2.15321400
76Dementia (HP:0000726)2.13179858
77Neuronal loss in central nervous system (HP:0002529)2.13089717
78Thin bony cortex (HP:0002753)2.12905652
79Epileptic encephalopathy (HP:0200134)2.12208022
80Astrocytoma (HP:0009592)2.10512620
81Abnormality of the astrocytes (HP:0100707)2.10512620
82Absence seizures (HP:0002121)2.09541226
83Hammertoe (HP:0001765)2.09185875
84Mitral regurgitation (HP:0001653)2.09002265
85Rapidly progressive (HP:0003678)2.06930284
86Abnormality of the Achilles tendon (HP:0005109)2.06512765
87Disinhibition (HP:0000734)2.05823972
88Hypercortisolism (HP:0001578)2.05781443
89Lower limb muscle weakness (HP:0007340)2.04191267
90Truncal ataxia (HP:0002078)2.02833481
91Shoulder girdle muscle weakness (HP:0003547)2.01199505
92Abnormal eating behavior (HP:0100738)1.99861145
93Postural instability (HP:0002172)1.98798060
94Megalencephaly (HP:0001355)1.98323965
95Abnormality of binocular vision (HP:0011514)1.95588837
96Diplopia (HP:0000651)1.95588837
97Cerebral inclusion bodies (HP:0100314)1.94780467
98Ventricular fibrillation (HP:0001663)1.94427444
99Hemiparesis (HP:0001269)1.94386009
100Bronchomalacia (HP:0002780)1.94377578
101Thoracic kyphosis (HP:0002942)1.93460378
102* Flat cornea (HP:0007720)1.93356279
103Myocardial infarction (HP:0001658)1.92101925
104Inappropriate behavior (HP:0000719)1.92048638
105Long toe (HP:0010511)1.91215950
106Impaired smooth pursuit (HP:0007772)1.90242824
107Long palpebral fissure (HP:0000637)1.88750122
108Broad face (HP:0000283)1.86595258
109Dialeptic seizures (HP:0011146)1.86179553
110Abnormality of the corticospinal tract (HP:0002492)1.85924676
111Amblyopia (HP:0000646)1.85841227
112* Sacral dimple (HP:0000960)1.85837405
113Abnormality of the vocal cords (HP:0008777)1.85622836
114Torticollis (HP:0000473)1.82159895
115Spinal rigidity (HP:0003306)1.80876123
116Abnormality of the thoracic spine (HP:0100711)1.80650348
117Distal lower limb amyotrophy (HP:0008944)1.80608120
118Clonus (HP:0002169)1.80145540
119Joint stiffness (HP:0001387)1.79468521
120Peripheral hypomyelination (HP:0007182)1.77844830
121Segmental peripheral demyelination/remyelination (HP:0003481)1.77658165
122Obstructive sleep apnea (HP:0002870)1.76457640
123Ulnar bowing (HP:0003031)1.75710382
124Heterotopia (HP:0002282)1.75011655
125Genu recurvatum (HP:0002816)1.74896449
126Ependymoma (HP:0002888)1.74575952
127Deformed sella turcica (HP:0002681)1.74475212
128Poor eye contact (HP:0000817)1.74352604
129Failure to thrive in infancy (HP:0001531)1.74145497
130Lower limb asymmetry (HP:0100559)1.73740344
131Stereotypic behavior (HP:0000733)1.73432107
132* Bladder diverticulum (HP:0000015)1.73272802
133Natal tooth (HP:0000695)1.73124623
134Abnormal social behavior (HP:0012433)1.72763502
135Impaired social interactions (HP:0000735)1.72763502
136Spinal canal stenosis (HP:0003416)1.67300694
137* Megalocornea (HP:0000485)1.67118328
138Abnormality of ocular smooth pursuit (HP:0000617)1.66785912
139Onion bulb formation (HP:0003383)1.66109109
140Bundle branch block (HP:0011710)1.65696555
141Dysmetria (HP:0001310)1.64674393
142Spondylolisthesis (HP:0003302)1.64159641
143Distal sensory impairment (HP:0002936)1.62691116
144Abnormality of pain sensation (HP:0010832)1.62311655
145Impaired pain sensation (HP:0007328)1.62311655
146Increased variability in muscle fiber diameter (HP:0003557)1.61053468
147Achilles tendon contracture (HP:0001771)1.60991106
148Dysmetric saccades (HP:0000641)1.60645029
149Generalized amyotrophy (HP:0003700)1.60090383
150Pathologic fracture (HP:0002756)1.59984169
151Stridor (HP:0010307)1.58932933
152Spastic tetraparesis (HP:0001285)1.57571773
153Disproportionate tall stature (HP:0001519)1.56728854
154Tetraplegia (HP:0002445)1.51367453
155Blue sclerae (HP:0000592)1.51217422
156Cellulitis (HP:0100658)1.50575654
157Global brain atrophy (HP:0002283)1.49725691
158Ocular albinism (HP:0001107)1.47674293
159Protuberant abdomen (HP:0001538)1.46630453
160Craniofacial dystonia (HP:0012179)1.45897866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.61020728
2MAP3K93.58715686
3MARK13.24794452
4IRAK33.22564533
5NTRK33.16371650
6MINK12.56747695
7PKN22.54641840
8PAK62.53134355
9PRPF4B2.45047432
10LATS22.40241366
11NTRK22.39153092
12EEF2K2.33354869
13MAP3K42.28778769
14PRKD32.21533521
15KSR22.19395218
16MAP3K112.11370705
17MAP3K132.09029986
18ARAF2.07960511
19CAMKK12.01557519
20SIK22.00445148
21ALK1.92215553
22NTRK11.87968496
23TYRO31.86406273
24RIPK11.85888846
25ERN11.79241398
26SMG11.77421962
27LMTK21.68250013
28RET1.67266998
29NME21.66680286
30SIK11.62268904
31TAOK11.61714342
32MOS1.61712146
33TTN1.58302981
34STK381.57167995
35ICK1.48524650
36SCYL21.37130175
37TAOK21.31741529
38PHKG21.31432391
39PHKG11.31432391
40DAPK21.31373291
41UHMK11.23266303
42CDK51.22532825
43PDGFRA1.20848807
44MAP2K41.20756155
45TESK11.20450442
46MAP2K71.17098208
47RPS6KA21.14290698
48FES1.13702128
49WNK11.12224047
50MAPK131.10655829
51MAP4K11.07131367
52MAP3K21.07056294
53CAMK1G1.05726616
54PRKCH1.00961936
55BMX1.00104134
56CDK120.96371640
57CAMKK20.95733372
58MARK20.95707962
59KSR10.94390805
60STK110.93179267
61BRAF0.92132396
62DMPK0.88401088
63IRAK40.88293015
64DDR20.87865367
65PAK40.86591469
66EPHB20.86033691
67GRK50.82000850
68TESK20.81687205
69ABL20.81543469
70CDK150.80104544
71IRAK20.76771813
72CDK140.75671715
73CDK180.75235503
74TNK20.75207941
75ZAP700.75196400
76MAP3K120.74502621
77RPS6KC10.74388722
78RPS6KL10.74388722
79MATK0.74230005
80MAP2K30.73561327
81BLK0.71514837
82CDK11A0.71099360
83EPHA40.70679187
84MAP3K140.69360698
85NEK10.68317938
86RIPK40.66499884
87CAMK1D0.65964607
88PDK10.65806547
89TBK10.65758131
90CSF1R0.64806069
91PTK60.64620085
92RPS6KA60.64411775
93CDK190.64172973
94PDPK10.61846592
95MAP3K100.60677895
96CSNK1G20.60398994
97ERBB40.60132804
98MAPK120.59104993
99DAPK10.57618928
100PTK20.55550918
101PDGFRB0.54716493
102PAK20.54634210
103ILK0.54538706
104CSK0.54371808
105NEK90.54126582
106PAK30.53652575
107TGFBR20.53560122
108MAPK100.53530929
109CAMK10.53470758
110PIM20.52978627
111LRRK20.52654788
112MAP3K80.52479424
113FGFR40.52285573
114MAP3K70.50932972
115PRKD20.50539133
116PRKCG0.49967351
117MTOR0.49474409
118FYN0.48103236
119FGR0.48074995
120PRKG20.46784143
121CAMK40.44368690
122PRKD10.43405956
123RPS6KA30.43101618
124DAPK30.42496078
125MAP3K30.41842930
126MAP3K10.41838112
127MAP2K10.41447164
128EPHB10.40070062
129ADRBK20.39895096
130PRKCZ0.39699589
131TNIK0.39644510
132ERBB20.39617625
133PNCK0.38688735
134RAF10.38050196
135SGK30.37753862
136MAPK80.37498816
137SRC0.37084070
138CSNK1E0.34694459
139HCK0.34635539
140SGK10.34341074
141* CDC42BPA0.34039566
142PLK20.33965168

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.45923928
2Lysosome_Homo sapiens_hsa041422.40830482
3Synaptic vesicle cycle_Homo sapiens_hsa047212.36368336
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29275618
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.22421878
6Nicotine addiction_Homo sapiens_hsa050331.95602920
7Olfactory transduction_Homo sapiens_hsa047401.90943017
8Long-term potentiation_Homo sapiens_hsa047201.74358205
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73664084
10Circadian entrainment_Homo sapiens_hsa047131.70097559
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69381967
12Glutamatergic synapse_Homo sapiens_hsa047241.66319485
13GABAergic synapse_Homo sapiens_hsa047271.62892135
14Glioma_Homo sapiens_hsa052141.58689922
15Osteoclast differentiation_Homo sapiens_hsa043801.58641086
16Dopaminergic synapse_Homo sapiens_hsa047281.55209700
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53659137
18Bladder cancer_Homo sapiens_hsa052191.53602657
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50215620
20Cholinergic synapse_Homo sapiens_hsa047251.47680192
21Morphine addiction_Homo sapiens_hsa050321.46560889
22Estrogen signaling pathway_Homo sapiens_hsa049151.44540454
23GnRH signaling pathway_Homo sapiens_hsa049121.42553448
24Dorso-ventral axis formation_Homo sapiens_hsa043201.42009459
25Gastric acid secretion_Homo sapiens_hsa049711.41578365
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.41346816
27Salivary secretion_Homo sapiens_hsa049701.41153595
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38683065
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34818832
30Insulin secretion_Homo sapiens_hsa049111.34036973
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32439180
32mTOR signaling pathway_Homo sapiens_hsa041501.31462297
33Endometrial cancer_Homo sapiens_hsa052131.30454477
34Gap junction_Homo sapiens_hsa045401.30363392
35Tuberculosis_Homo sapiens_hsa051521.29651581
36ErbB signaling pathway_Homo sapiens_hsa040121.28819569
37Notch signaling pathway_Homo sapiens_hsa043301.28572278
38Type II diabetes mellitus_Homo sapiens_hsa049301.27944824
39Oxytocin signaling pathway_Homo sapiens_hsa049211.26751841
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26355527
41VEGF signaling pathway_Homo sapiens_hsa043701.25372746
42* Axon guidance_Homo sapiens_hsa043601.24308695
43Amphetamine addiction_Homo sapiens_hsa050311.23318175
44Rheumatoid arthritis_Homo sapiens_hsa053231.22805096
45Long-term depression_Homo sapiens_hsa047301.21438682
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.19330292
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19250454
48Leishmaniasis_Homo sapiens_hsa051401.18755321
49Colorectal cancer_Homo sapiens_hsa052101.17668541
50Phagosome_Homo sapiens_hsa041451.16686036
51Non-small cell lung cancer_Homo sapiens_hsa052231.16505749
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15716390
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15501164
54Vibrio cholerae infection_Homo sapiens_hsa051101.14597731
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13591587
56* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12596484
57Renin secretion_Homo sapiens_hsa049241.11231476
58Chronic myeloid leukemia_Homo sapiens_hsa052201.10572724
59Taste transduction_Homo sapiens_hsa047421.09759545
60TNF signaling pathway_Homo sapiens_hsa046681.08016306
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07704677
62Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02245971
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.01127296
64Cocaine addiction_Homo sapiens_hsa050301.00374872
65cAMP signaling pathway_Homo sapiens_hsa040240.99923887
66Renal cell carcinoma_Homo sapiens_hsa052110.98776182
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98756152
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97852609
69Melanogenesis_Homo sapiens_hsa049160.94297639
70Malaria_Homo sapiens_hsa051440.94039665
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94026214
72Choline metabolism in cancer_Homo sapiens_hsa052310.92992818
73MAPK signaling pathway_Homo sapiens_hsa040100.92560838
74Endocytosis_Homo sapiens_hsa041440.91149785
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91086305
76Oocyte meiosis_Homo sapiens_hsa041140.89803401
77Rap1 signaling pathway_Homo sapiens_hsa040150.88669771
78Serotonergic synapse_Homo sapiens_hsa047260.88087253
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87901307
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87783910
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87089878
82Amoebiasis_Homo sapiens_hsa051460.86435283
83Calcium signaling pathway_Homo sapiens_hsa040200.84846296
84Toxoplasmosis_Homo sapiens_hsa051450.84089139
85Insulin signaling pathway_Homo sapiens_hsa049100.83892655
86Nitrogen metabolism_Homo sapiens_hsa009100.83875649
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83846533
88Acute myeloid leukemia_Homo sapiens_hsa052210.83542034
89Shigellosis_Homo sapiens_hsa051310.83242372
90Pancreatic cancer_Homo sapiens_hsa052120.82421499
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81672542
92Dilated cardiomyopathy_Homo sapiens_hsa054140.81481276
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79309008
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.79294538
95Prolactin signaling pathway_Homo sapiens_hsa049170.79209470
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.78399735
97Platelet activation_Homo sapiens_hsa046110.77908041
98Ras signaling pathway_Homo sapiens_hsa040140.74827238
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73924143
100B cell receptor signaling pathway_Homo sapiens_hsa046620.73732032
101Pertussis_Homo sapiens_hsa051330.73509221
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.73106203
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73051287
104Proteoglycans in cancer_Homo sapiens_hsa052050.72477567
105* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70551307
106Chemokine signaling pathway_Homo sapiens_hsa040620.70056586
107Apoptosis_Homo sapiens_hsa042100.70034447
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69996273
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69803236
110Focal adhesion_Homo sapiens_hsa045100.69572232
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69491209
112Thyroid cancer_Homo sapiens_hsa052160.69296370
113Collecting duct acid secretion_Homo sapiens_hsa049660.69229229
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67512162
115Prion diseases_Homo sapiens_hsa050200.65397869
116Staphylococcus aureus infection_Homo sapiens_hsa051500.64852822
117Vitamin B6 metabolism_Homo sapiens_hsa007500.64027557
118Wnt signaling pathway_Homo sapiens_hsa043100.62224997
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.62059452
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61601901
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61551386
122Salmonella infection_Homo sapiens_hsa051320.60389521
123Hedgehog signaling pathway_Homo sapiens_hsa043400.57328629
124Hippo signaling pathway_Homo sapiens_hsa043900.57269888
125Influenza A_Homo sapiens_hsa051640.57141626
126Hepatitis C_Homo sapiens_hsa051600.55979754
127Melanoma_Homo sapiens_hsa052180.55703080
128Thyroid hormone synthesis_Homo sapiens_hsa049180.55572691
129T cell receptor signaling pathway_Homo sapiens_hsa046600.55306606
130Hepatitis B_Homo sapiens_hsa051610.54745933
131ECM-receptor interaction_Homo sapiens_hsa045120.54179885

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