LIMK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47911477
2negative regulation of cell killing (GO:0031342)5.47911477
3ribosomal small subunit biogenesis (GO:0042274)5.32372206
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.20594727
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.20594727
6modulation by symbiont of host immune response (GO:0052553)5.20594727
7positive regulation by symbiont of host defense response (GO:0052509)5.20594727
8modulation by symbiont of host defense response (GO:0052031)5.20594727
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.20594727
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03404560
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.94598587
12positive regulation of gamma-delta T cell activation (GO:0046645)4.84753447
13detection of other organism (GO:0098543)4.66732060
14maturation of SSU-rRNA (GO:0030490)4.62543111
15macrophage activation involved in immune response (GO:0002281)4.61913583
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52740468
17antigen processing and presentation of endogenous antigen (GO:0019883)4.52635251
18detection of bacterium (GO:0016045)4.37746456
19viral transcription (GO:0019083)4.37433494
20response to peptidoglycan (GO:0032494)4.32434882
21negative regulation of interleukin-12 production (GO:0032695)4.29128654
22detection of molecule of bacterial origin (GO:0032490)4.24628317
23translational termination (GO:0006415)4.22426073
24ribosome assembly (GO:0042255)4.17905455
25neutrophil activation involved in immune response (GO:0002283)4.08160202
26detection of external biotic stimulus (GO:0098581)4.07174506
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.03360809
28leukocyte aggregation (GO:0070486)4.03008125
29protein-cofactor linkage (GO:0018065)4.00380153
30regulation of interferon-beta biosynthetic process (GO:0045357)3.92576732
31ribosomal large subunit biogenesis (GO:0042273)3.91014623
32rRNA modification (GO:0000154)3.89194137
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.76937901
34ribonucleoprotein complex biogenesis (GO:0022613)3.75685992
35type I interferon signaling pathway (GO:0060337)3.73589003
36cellular response to type I interferon (GO:0071357)3.73589003
37response to type I interferon (GO:0034340)3.71901384
38germinal center formation (GO:0002467)3.71504927
39regulation of nuclear cell cycle DNA replication (GO:0033262)3.70692775
40DNA damage response, detection of DNA damage (GO:0042769)3.70265082
41regulation of gamma-delta T cell activation (GO:0046643)3.69545255
42regulation of T-helper 2 cell differentiation (GO:0045628)3.63356982
43translational elongation (GO:0006414)3.60664057
44cellular protein complex disassembly (GO:0043624)3.59163327
45response to muramyl dipeptide (GO:0032495)3.54643982
46detection of biotic stimulus (GO:0009595)3.54364075
47nucleoside diphosphate catabolic process (GO:0009134)3.53525134
48cellular extravasation (GO:0045123)3.52583860
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.50603954
50response to host immune response (GO:0052572)3.50603954
51translational initiation (GO:0006413)3.47935158
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43665381
53histone H4-K8 acetylation (GO:0043982)3.43473983
54histone H4-K5 acetylation (GO:0043981)3.43473983
55spliceosomal complex assembly (GO:0000245)3.43239659
56histone H4-K12 acetylation (GO:0043983)3.42550718
57termination of RNA polymerase III transcription (GO:0006386)3.42210337
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.42210337
59spliceosomal snRNP assembly (GO:0000387)3.41786917
60production of molecular mediator involved in inflammatory response (GO:0002532)3.41331108
61neutrophil activation (GO:0042119)3.40898863
62regulation of tolerance induction (GO:0002643)3.37562615
63regulation of B cell receptor signaling pathway (GO:0050855)3.36436703
64macrophage activation (GO:0042116)3.35945277
65leukocyte migration involved in inflammatory response (GO:0002523)3.35859623
66negative regulation of leukocyte mediated immunity (GO:0002704)3.34779989
67negative regulation of T cell mediated immunity (GO:0002710)3.34702288
68immunoglobulin mediated immune response (GO:0016064)3.33166332
69DNA deamination (GO:0045006)3.32692461
70respiratory burst (GO:0045730)3.30985433
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29824015
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29337799
73response to host (GO:0075136)3.28118732
74response to host defenses (GO:0052200)3.28118732
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28118732
76tolerance induction (GO:0002507)3.26678804
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26625258
78granulocyte activation (GO:0036230)3.26301204
79deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.25536928
80response to interleukin-15 (GO:0070672)3.25400554
81positive regulation of tolerance induction (GO:0002645)3.25073581
82lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24920962
83cotranslational protein targeting to membrane (GO:0006613)3.24358325
84viral life cycle (GO:0019058)3.23214263
85protein targeting to ER (GO:0045047)3.21673100
86regulation of T cell tolerance induction (GO:0002664)3.20855764
87ribosome biogenesis (GO:0042254)3.20215267
88DNA replication checkpoint (GO:0000076)3.19395464
89regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19068381
90synaptonemal complex assembly (GO:0007130)3.17306137
91cellular response to electrical stimulus (GO:0071257)3.16661667
92microglial cell activation (GO:0001774)3.15651483
93deoxyribonucleotide biosynthetic process (GO:0009263)3.15208016
94protein complex disassembly (GO:0043241)3.14705945
95negative regulation of erythrocyte differentiation (GO:0045647)3.14692753
96rRNA processing (GO:0006364)3.13436856
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10490279
98negative regulation of T-helper cell differentiation (GO:0045623)3.10490279
99positive regulation of Cdc42 GTPase activity (GO:0043089)3.09384831
100establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08454575
101myeloid cell activation involved in immune response (GO:0002275)3.06817851
102negative regulation of type 2 immune response (GO:0002829)3.06363139
103interferon-gamma-mediated signaling pathway (GO:0060333)3.05625625
104establishment of integrated proviral latency (GO:0075713)3.04379652
105rRNA metabolic process (GO:0016072)3.03017746
106proteasome assembly (GO:0043248)3.01350442
107regulation of gamma-delta T cell differentiation (GO:0045586)3.00850081
108macromolecular complex disassembly (GO:0032984)3.00109473
109defense response to protozoan (GO:0042832)2.99520685
110positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98620829
111rRNA methylation (GO:0031167)2.98012941
112negative regulation of microtubule polymerization (GO:0031115)2.97959999
113establishment of protein localization to mitochondrial membrane (GO:0090151)2.97699127
114protein localization to endoplasmic reticulum (GO:0070972)2.96551653
115positive regulation of type 2 immune response (GO:0002830)2.95301904
116negative regulation of toll-like receptor signaling pathway (GO:0034122)2.95089848
117regulation of helicase activity (GO:0051095)2.94709163
118negative regulation of cytokine production involved in immune response (GO:0002719)2.93075959
119interferon-gamma secretion (GO:0072643)2.91580936
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90677407
121NIK/NF-kappaB signaling (GO:0038061)2.90550324
122translation (GO:0006412)2.89515762
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.89045720
124neutrophil mediated immunity (GO:0002446)2.88580514
125regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.88536066
126regulation of type 2 immune response (GO:0002828)2.87372062
1277-methylguanosine mRNA capping (GO:0006370)2.84415069
128termination of RNA polymerase I transcription (GO:0006363)2.84362044
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83668405
130T-helper 1 type immune response (GO:0042088)2.83541664
131regulation of T-helper 1 cell differentiation (GO:0045625)2.83320466
132positive regulation of interferon-alpha production (GO:0032727)2.83160945
133keratinocyte development (GO:0003334)2.82235335
134negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81774668
135regulation of interferon-alpha production (GO:0032647)2.81462442
136regulation of mast cell degranulation (GO:0043304)2.80667902
137chromatin remodeling at centromere (GO:0031055)2.80156986
138transcription from RNA polymerase I promoter (GO:0006360)2.79132496
139regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79015864
140histone arginine methylation (GO:0034969)2.78425574
141regulation of centriole replication (GO:0046599)2.77976034
142regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.77556622
143mitotic metaphase plate congression (GO:0007080)2.77516208
144regulation of telomere maintenance via telomerase (GO:0032210)2.77114468
145telomere maintenance via semi-conservative replication (GO:0032201)2.76722745
146response to protozoan (GO:0001562)2.75556410
147cellular response to interleukin-15 (GO:0071350)2.75010326
148synaptonemal complex organization (GO:0070193)2.74720293
149negative regulation of interleukin-6 production (GO:0032715)2.74628336
150kinetochore assembly (GO:0051382)2.74553836
151positive regulation of cellular amide metabolic process (GO:0034250)2.74471863
152regulation of leukocyte degranulation (GO:0043300)2.74336062
153RNA capping (GO:0036260)2.74273515
1547-methylguanosine RNA capping (GO:0009452)2.74273515
155DNA strand elongation involved in DNA replication (GO:0006271)2.74134431
156mitochondrial DNA replication (GO:0006264)2.74036083
157regulation of toll-like receptor signaling pathway (GO:0034121)2.71496843
158cellular component biogenesis (GO:0044085)2.70866604
159CENP-A containing nucleosome assembly (GO:0034080)2.70252605
160protein localization to endosome (GO:0036010)2.69543547
161transcription elongation from RNA polymerase I promoter (GO:0006362)2.69398263
162negative regulation of innate immune response (GO:0045824)2.68957857
163tongue development (GO:0043586)2.67981229
164positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67642577
165regulation of gene silencing by RNA (GO:0060966)2.67540035
166regulation of posttranscriptional gene silencing (GO:0060147)2.67540035
167regulation of gene silencing by miRNA (GO:0060964)2.67540035
168DNA replication initiation (GO:0006270)2.66792165
169JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65458198
170energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63030235
171ATP synthesis coupled proton transport (GO:0015986)2.63030235
172dendritic cell chemotaxis (GO:0002407)2.62627050
173cell migration involved in gastrulation (GO:0042074)2.62479512
174antigen processing and presentation via MHC class Ib (GO:0002475)2.62254642
175negative regulation of androgen receptor signaling pathway (GO:0060766)2.61067284
176piRNA metabolic process (GO:0034587)2.59562166
177transcription-coupled nucleotide-excision repair (GO:0006283)2.58523311
178preassembly of GPI anchor in ER membrane (GO:0016254)2.58157458
179negative regulation of alpha-beta T cell activation (GO:0046636)2.57844520
180DNA strand elongation (GO:0022616)2.54686735
181nucleobase-containing small molecule interconversion (GO:0015949)2.52901037
182peptidyl-arginine omega-N-methylation (GO:0035247)2.52762004
183telomere maintenance via telomere lengthening (GO:0010833)2.52554567
184negative regulation of telomerase activity (GO:0051974)2.51123474
185deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.50285071
186exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49349901
187ribosomal small subunit assembly (GO:0000028)2.46250409
188histone exchange (GO:0043486)2.45117056
189tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42779807
190RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42779807
191single strand break repair (GO:0000012)2.40935890
192RNA destabilization (GO:0050779)2.40836878
193lung-associated mesenchyme development (GO:0060484)2.40437630
194regulation of short-term neuronal synaptic plasticity (GO:0048172)2.40365438
195DNA-dependent DNA replication (GO:0006261)2.40187197
196nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39754381
197transcription initiation from RNA polymerase I promoter (GO:0006361)2.39329636
198cell fate commitment involved in formation of primary germ layer (GO:0060795)2.39252578
199nucleobase biosynthetic process (GO:0046112)2.38369283
200formation of translation preinitiation complex (GO:0001731)2.37409569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.35244537
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.17804173
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.92012798
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.62779604
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.45715102
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18331319
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.13265038
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01281233
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.98144200
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.94137825
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89278381
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.87790123
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.87790123
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.87790123
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84954303
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82626082
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.82076419
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77359712
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72610600
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.67097204
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59707495
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.53597740
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53154786
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51644236
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51261735
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51143696
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44302283
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42942950
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41325330
30VDR_21846776_ChIP-Seq_THP-1_Human2.35229579
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33363325
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31856336
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31169724
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29242024
35KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28355046
36XRN2_22483619_ChIP-Seq_HELA_Human2.25455079
37VDR_24763502_ChIP-Seq_THP-1_Human2.19790661
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18021417
39STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17655553
40FOXM1_23109430_ChIP-Seq_U2OS_Human2.16930131
41CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06724984
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05560202
43MAF_26560356_Chip-Seq_TH1_Human2.05072595
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04640826
45EGR1_19374776_ChIP-ChIP_THP-1_Human2.03797572
46TCF7_22412390_ChIP-Seq_EML_Mouse2.01757839
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01189239
48RUNX_20019798_ChIP-Seq_JUKART_Human2.00748679
49SPI1_23127762_ChIP-Seq_K562_Human2.00678420
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00153522
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98668884
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96314084
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94749506
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93956261
55EZH2_22144423_ChIP-Seq_EOC_Human1.93076916
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.92120418
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89996936
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88371209
59* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88243063
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.86811040
61TTF2_22483619_ChIP-Seq_HELA_Human1.86691346
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.84086261
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82543327
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81619111
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80483312
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78336537
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77958264
68KDM2B_26808549_Chip-Seq_DND41_Human1.77907623
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77797785
70SPI1_23547873_ChIP-Seq_NB4_Human1.77456519
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76459877
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74086506
73MYC_22102868_ChIP-Seq_BL_Human1.73945979
74UTX_26944678_Chip-Seq_JUKART_Human1.73251910
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72665744
76* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72315745
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.69576767
78LXR_22292898_ChIP-Seq_THP-1_Human1.66597715
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63947047
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62860001
81MYB_26560356_Chip-Seq_TH2_Human1.62207229
82* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60387165
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.59716071
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.56538169
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53552354
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52214642
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51673757
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51498017
89SCL_19346495_ChIP-Seq_HPC-7_Human1.50911384
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.50492305
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50452333
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49271818
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47042824
94MAF_26560356_Chip-Seq_TH2_Human1.46798502
95MYB_26560356_Chip-Seq_TH1_Human1.46002975
96* RACK7_27058665_Chip-Seq_MCF-7_Human1.45956015
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45486823
98* GATA1_19941827_ChIP-Seq_MEL_Mouse1.43974235
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43442030
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.43101381
101VDR_23849224_ChIP-Seq_CD4+_Human1.43049975
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42745584
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42708712
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42060145
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41652965
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39703742
107VDR_24787735_ChIP-Seq_THP-1_Human1.38831107
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37671910
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35469920
110ELK1_22589737_ChIP-Seq_MCF10A_Human1.35114177
111GATA1_26923725_Chip-Seq_HPCs_Mouse1.35109891
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33994512
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.29719231
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29372862
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27605129
116GATA1_19941826_ChIP-Seq_K562_Human1.27397489
117* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26797051
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26656476
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.25853366
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24885684
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24660380
122DCP1A_22483619_ChIP-Seq_HELA_Human1.24345287
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.23729514
124KDM2B_26808549_Chip-Seq_K562_Human1.23542009
125* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19844803
126* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19644433
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19566618
128FOXP3_21729870_ChIP-Seq_TREG_Human1.19092432
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18974341
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18157529
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18032314
132* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17937622
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17661606
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17129544
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16926948
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14597548
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14591642
138GATA3_27048872_Chip-Seq_THYMUS_Human1.14317900
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14234430
140YY1_22570637_ChIP-Seq_MALME-3M_Human1.12947823
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12803024
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12419060
143PU_27001747_Chip-Seq_BMDM_Mouse1.12078201
144KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11948573
145ELK1_19687146_ChIP-ChIP_HELA_Human1.11806457
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11590705
147AR_21909140_ChIP-Seq_LNCAP_Human1.11566383
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10439060
149GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10270236
150NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10092311
151TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08383233
152SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08163399
153DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07831961
154NANOG_16153702_ChIP-ChIP_HESCs_Human1.07758230
155GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07754765
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07053802
157GABP_19822575_ChIP-Seq_HepG2_Human1.06540978
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05459248
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05255078
160CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04778605
161ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04606825
162CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02232525
163YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00475386
164TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00120174
165FOXO3_23340844_ChIP-Seq_DLD1_Human0.99547134
166POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99193806
167CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99031123
168GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98629475
169PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98567420
170SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97787180
171NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97768598
172SA1_27219007_Chip-Seq_ERYTHROID_Human0.96709518
173SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96682587
174TP63_19390658_ChIP-ChIP_HaCaT_Human0.94705602
175SOX2_16153702_ChIP-ChIP_HESCs_Human0.94548638
176EGR1_19032775_ChIP-ChIP_M12_Human0.94332037
177POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.94291890
178BCOR_27268052_Chip-Seq_Bcells_Human0.94032417
179ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93971448
180NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93173589
181SMC4_20622854_ChIP-Seq_HELA_Human0.93093947
182KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90592868
183NCOR1_26117541_ChIP-Seq_K562_Human0.90567188
184RUNX1_27514584_Chip-Seq_MCF-7_Human0.90533465
185* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89068879
186BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88855832
187* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88800580
188* GATA2_19941826_ChIP-Seq_K562_Human0.88483018
189* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88369275
190NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87996431
191VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87877824
192SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87379641
193* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87365789
194ERG_21242973_ChIP-ChIP_JURKAT_Human0.87357684
195BCL6_27268052_Chip-Seq_Bcells_Human0.86323555
196ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85519694
197SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82433164
198SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82422570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous5.01219508
2MP0003724_increased_susceptibility_to4.96738871
3MP0003303_peritoneal_inflammation4.50145406
4MP0003436_decreased_susceptibility_to3.93653018
5MP0001986_abnormal_taste_sensitivity3.37861233
6MP0003941_abnormal_skin_development3.34266558
7MP0009379_abnormal_foot_pigmentation3.01096592
8MP0001835_abnormal_antigen_presentation2.92033346
9MP0003300_gastrointestinal_ulcer2.91564957
10MP0009785_altered_susceptibility_to2.72598297
11MP0002419_abnormal_innate_immunity2.68258427
12MP0003693_abnormal_embryo_hatching2.66506680
13MP0005025_abnormal_response_to2.62616188
14MP0008260_abnormal_autophagy2.57036370
15MP0001790_abnormal_immune_system2.56559314
16MP0005387_immune_system_phenotype2.56559314
17MP0003111_abnormal_nucleus_morphology2.53570225
18MP0000566_synostosis2.49631099
19MP0005000_abnormal_immune_tolerance2.47289977
20MP0003191_abnormal_cellular_cholesterol2.43725112
21MP0001800_abnormal_humoral_immune2.41421466
22MP0003880_abnormal_central_pattern2.36805130
23MP0004947_skin_inflammation2.35018122
24MP0006082_CNS_inflammation2.33669374
25MP0000685_abnormal_immune_system2.28415856
26MP0004145_abnormal_muscle_electrophysio2.26272895
27MP0004957_abnormal_blastocyst_morpholog2.23241222
28MP0001533_abnormal_skeleton_physiology2.18996391
29MP0002723_abnormal_immune_serum2.18938527
30MP0004859_abnormal_synaptic_plasticity2.17693030
31MP0002148_abnormal_hypersensitivity_rea2.17229563
32MP0005671_abnormal_response_to2.14082687
33MP0002452_abnormal_antigen_presenting2.13599488
34MP0005451_abnormal_body_composition2.08101551
35MP0001819_abnormal_immune_cell2.06299591
36MP0010155_abnormal_intestine_physiology2.06210705
37MP0002420_abnormal_adaptive_immunity2.05958169
38MP0002796_impaired_skin_barrier1.99656265
39MP0003123_paternal_imprinting1.97601608
40MP0003763_abnormal_thymus_physiology1.96716004
41MP0001188_hyperpigmentation1.93179712
42MP0004133_heterotaxia1.87805577
43MP0010094_abnormal_chromosome_stability1.84219630
44MP0008932_abnormal_embryonic_tissue1.82094636
45MP0008877_abnormal_DNA_methylation1.81668836
46MP0003283_abnormal_digestive_organ1.81308480
47MP0008058_abnormal_DNA_repair1.79030283
48MP0009278_abnormal_bone_marrow1.78991244
49MP0003453_abnormal_keratinocyte_physiol1.76841346
50MP0002405_respiratory_system_inflammati1.76535543
51MP0000465_gastrointestinal_hemorrhage1.75028105
52MP0000762_abnormal_tongue_morphology1.63857185
53MP0008057_abnormal_DNA_replication1.63434509
54MP0000858_altered_metastatic_potential1.61767333
55MP0003077_abnormal_cell_cycle1.60768555
56MP0001845_abnormal_inflammatory_respons1.59998836
57MP0003136_yellow_coat_color1.59452616
58MP0009764_decreased_sensitivity_to1.57767228
59MP0003635_abnormal_synaptic_transmissio1.57521148
60MP0004510_myositis1.56707934
61MP0003828_pulmonary_edema1.54528333
62MP0003315_abnormal_perineum_morphology1.53044952
63MP0000716_abnormal_immune_system1.51868834
64MP0000579_abnormal_nail_morphology1.50610655
65MP0004270_analgesia1.49898674
66MP0003718_maternal_effect1.48563743
67MP0003705_abnormal_hypodermis_morpholog1.48059990
68MP0003866_abnormal_defecation1.47174161
69MP0003075_altered_response_to1.46362055
70MP0005464_abnormal_platelet_physiology1.46055911
71MP0009333_abnormal_splenocyte_physiolog1.43763550
72MP0002398_abnormal_bone_marrow1.43137279
73MP0003172_abnormal_lysosome_physiology1.40446589
74MP0003566_abnormal_cell_adhesion1.40349324
75MP0002184_abnormal_innervation1.40039024
76MP0000537_abnormal_urethra_morphology1.37081694
77MP0004264_abnormal_extraembryonic_tissu1.36702556
78MP0002132_abnormal_respiratory_system1.36276952
79MP0003786_premature_aging1.35569719
80MP0002734_abnormal_mechanical_nocicepti1.33505482
81MP0008469_abnormal_protein_level1.31619091
82MP0006072_abnormal_retinal_apoptosis1.31331394
83MP0004883_abnormal_blood_vessel1.30372957
84MP0003183_abnormal_peptide_metabolism1.29982084
85MP0005501_abnormal_skin_physiology1.29217320
86MP0005310_abnormal_salivary_gland1.28374812
87MP0005058_abnormal_lysosome_morphology1.25648381
88MP0001851_eye_inflammation1.25324163
89MP0002998_abnormal_bone_remodeling1.24515782
90MP0008004_abnormal_stomach_pH1.23988379
91MP0005164_abnormal_response_to1.23436769
92MP0001968_abnormal_touch/_nociception1.22845903
93MP0002722_abnormal_immune_system1.20505022
94MP0003119_abnormal_digestive_system1.19545755
95MP0008007_abnormal_cellular_replicative1.18642220
96MP0002751_abnormal_autonomic_nervous1.18175552
97MP0002254_reproductive_system_inflammat1.16808368
98MP0002653_abnormal_ependyma_morphology1.16738770
99MP0002429_abnormal_blood_cell1.16625791
100MP0003448_altered_tumor_morphology1.15908288
101MP0005166_decreased_susceptibility_to1.13875676
102MP0003091_abnormal_cell_migration1.13054041
103MP0010234_abnormal_vibrissa_follicle1.12565482
104MP0005397_hematopoietic_system_phenotyp1.12314692
105MP0001545_abnormal_hematopoietic_system1.12314692
106MP0000778_abnormal_nervous_system1.11611974
107MP0001849_ear_inflammation1.09547526
108MP0000689_abnormal_spleen_morphology1.09199782
109MP0000467_abnormal_esophagus_morphology1.08394514
110MP0006292_abnormal_olfactory_placode1.08064319
111MP0005499_abnormal_olfactory_system1.08050767
112MP0005394_taste/olfaction_phenotype1.08050767
113MP0002234_abnormal_pharynx_morphology1.05982084
114MP0009745_abnormal_behavioral_response1.05762261
115MP0001440_abnormal_grooming_behavior1.05186834
116MP0005023_abnormal_wound_healing1.05007258
117MP0002063_abnormal_learning/memory/cond1.04858150
118MP0002160_abnormal_reproductive_system1.04336280
119* MP0002210_abnormal_sex_determination1.03809371
120MP0008789_abnormal_olfactory_epithelium1.03365148
121MP0006276_abnormal_autonomic_nervous1.02032285
122MP0000703_abnormal_thymus_morphology1.00924490
123MP0003755_abnormal_palate_morphology1.00805351
124MP0002735_abnormal_chemical_nociception1.00060905
125MP0009046_muscle_twitch0.99863611
126MP0000955_abnormal_spinal_cord0.99834439
127MP0001216_abnormal_epidermal_layer0.99688504
128MP0001485_abnormal_pinna_reflex0.98880428
129MP0000462_abnormal_digestive_system0.98442624
130MP0003861_abnormal_nervous_system0.97953300
131MP0002572_abnormal_emotion/affect_behav0.97558656
132MP0003938_abnormal_ear_development0.96664195
133MP0002396_abnormal_hematopoietic_system0.96420859
134MP0000647_abnormal_sebaceous_gland0.96051611
135MP0000604_amyloidosis0.95134877
136MP0003690_abnormal_glial_cell0.95111804
137MP0001730_embryonic_growth_arrest0.95079616
138MP0009840_abnormal_foam_cell0.93885917
139MP0001486_abnormal_startle_reflex0.93786782
140MP0002272_abnormal_nervous_system0.93084936
141MP0002752_abnormal_somatic_nervous0.92947359
142MP0002085_abnormal_embryonic_tissue0.91455474
143MP0001529_abnormal_vocalization0.90374333
144MP0005076_abnormal_cell_differentiation0.89907679
145MP0003890_abnormal_embryonic-extraembry0.89859440
146MP0005390_skeleton_phenotype0.89848632
147MP0010030_abnormal_orbit_morphology0.89670040
148MP0000613_abnormal_salivary_gland0.88909593
149MP0002733_abnormal_thermal_nociception0.88552503
150* MP0001145_abnormal_male_reproductive0.88139212
151MP0002882_abnormal_neuron_morphology0.88042189
152MP0002332_abnormal_exercise_endurance0.87877483
153MP0004885_abnormal_endolymph0.87568774
154MP0001970_abnormal_pain_threshold0.87420837
155MP0000350_abnormal_cell_proliferation0.87041916
156MP0005377_hearing/vestibular/ear_phenot0.86591565
157MP0003878_abnormal_ear_physiology0.86591565
158MP0002064_seizures0.86091985
159MP0003121_genomic_imprinting0.85575889
160MP0001853_heart_inflammation0.83160151
161MP0004858_abnormal_nervous_system0.83042531
162MP0003045_fibrosis0.82983884
163MP0002736_abnormal_nociception_after0.81888432
164MP0002102_abnormal_ear_morphology0.80835283
165MP0005409_darkened_coat_color0.80795027
166MP0003937_abnormal_limbs/digits/tail_de0.80584119
167MP0002277_abnormal_respiratory_mucosa0.80189742
168MP0002557_abnormal_social/conspecific_i0.79269162
169MP0004381_abnormal_hair_follicle0.78636045
170* MP0000653_abnormal_sex_gland0.78515440
171MP0002098_abnormal_vibrissa_morphology0.78513974
172MP0009765_abnormal_xenobiotic_induced0.78276739
173MP0002084_abnormal_developmental_patter0.78067966
174MP0005253_abnormal_eye_physiology0.77942478
175MP0003656_abnormal_erythrocyte_physiolo0.77871255
176MP0005623_abnormal_meninges_morphology0.77794746
177MP0000490_abnormal_crypts_of0.77433557
178MP0001663_abnormal_digestive_system0.77358564
179MP0010352_gastrointestinal_tract_polyps0.75943137
180MP0002233_abnormal_nose_morphology0.75877360
181MP0004142_abnormal_muscle_tone0.75747883
182MP0005187_abnormal_penis_morphology0.75538070
183MP0001873_stomach_inflammation0.75332018
184MP0009763_increased_sensitivity_to0.75194798
185MP0003329_amyloid_beta_deposits0.74819567
186MP0002933_joint_inflammation0.74422114
187MP0000049_abnormal_middle_ear0.74202165
188MP0000343_altered_response_to0.73158441
189MP0000249_abnormal_blood_vessel0.69673878
190MP0009931_abnormal_skin_appearance0.67734249
191MP0002138_abnormal_hepatobiliary_system0.65684421
192MP0002166_altered_tumor_susceptibility0.64526888

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)7.54333404
2Abnormality of the renal collecting system (HP:0004742)6.63611343
3Eczematoid dermatitis (HP:0000976)6.17931826
4Myositis (HP:0100614)5.27227278
5Orchitis (HP:0100796)5.24856726
6Recurrent bacterial skin infections (HP:0005406)5.15883093
7Hypoplastic nipples (HP:0002557)4.94671398
8Acute lymphatic leukemia (HP:0006721)4.91004366
9Optic neuritis (HP:0100653)4.90990032
10Retrobulbar optic neuritis (HP:0100654)4.90990032
11Long foot (HP:0001833)4.88242244
12Recurrent abscess formation (HP:0002722)4.88188124
13Progressive external ophthalmoplegia (HP:0000590)4.71064273
14Abnormality of macrophages (HP:0004311)4.58234096
15Breast hypoplasia (HP:0003187)4.27822989
16Adactyly (HP:0009776)4.19869557
17Ureteral duplication (HP:0000073)4.06043252
18Stomatitis (HP:0010280)3.87657699
19Increased IgE level (HP:0003212)3.86301555
20Recurrent gram-negative bacterial infections (HP:0005420)3.83566046
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.77550525
22Keratoconjunctivitis sicca (HP:0001097)3.77260000
23Elevated erythrocyte sedimentation rate (HP:0003565)3.69710694
24Gastrointestinal infarctions (HP:0005244)3.50718354
25Reticulocytopenia (HP:0001896)3.50392081
26Broad-based gait (HP:0002136)3.44506332
27Mediastinal lymphadenopathy (HP:0100721)3.43017307
28Keratoconjunctivitis (HP:0001096)3.37104581
29Congenital stationary night blindness (HP:0007642)3.29329292
30Gingivitis (HP:0000230)3.27137202
31Recurrent fungal infections (HP:0002841)3.22675244
32Abnormality of the labia minora (HP:0012880)3.18111538
33Recurrent skin infections (HP:0001581)3.09553506
34Large for gestational age (HP:0001520)3.08065853
35Chronic obstructive pulmonary disease (HP:0006510)3.01821984
36Obstructive lung disease (HP:0006536)3.01821984
37Vasculitis (HP:0002633)2.97397498
38Ureteral stenosis (HP:0000071)2.97349378
39Meningitis (HP:0001287)2.96756301
40Urticaria (HP:0001025)2.93356752
41Spontaneous hematomas (HP:0007420)2.90170537
42Nasal polyposis (HP:0100582)2.87240852
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.83877804
44Transposition of the great arteries (HP:0001669)2.82925264
45Abnormal connection of the cardiac segments (HP:0011545)2.82925264
46Abnormal ventriculo-arterial connection (HP:0011563)2.82925264
47Absent radius (HP:0003974)2.75704553
48Thick nail (HP:0001805)2.75519418
49Aplasia involving forearm bones (HP:0009822)2.75432635
50Absent forearm bone (HP:0003953)2.75432635
51Encephalitis (HP:0002383)2.74455908
52Interstitial pulmonary disease (HP:0006530)2.73668411
53Milia (HP:0001056)2.73311337
54Abnormality of the nasal mucosa (HP:0000433)2.69736670
55Peritonitis (HP:0002586)2.67742365
56Cellulitis (HP:0100658)2.66697779
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65358179
58Birth length less than 3rd percentile (HP:0003561)2.62954942
59Pustule (HP:0200039)2.61977771
60Macrocytic anemia (HP:0001972)2.61203535
61Cerebral hypomyelination (HP:0006808)2.59665663
62External ophthalmoplegia (HP:0000544)2.59146973
63Ureteral obstruction (HP:0006000)2.58185905
64Abnormality of cells of the erythroid lineage (HP:0012130)2.57710091
65Hemoptysis (HP:0002105)2.57317663
66Amyloidosis (HP:0011034)2.57290404
67Aplasia/Hypoplasia of the nipples (HP:0006709)2.55675124
68Abnormality of nail color (HP:0100643)2.55261177
69Pulmonary artery stenosis (HP:0004415)2.54229352
70Gangrene (HP:0100758)2.50343866
71T lymphocytopenia (HP:0005403)2.49210802
72Premature loss of primary teeth (HP:0006323)2.48712198
73Episodic fever (HP:0001954)2.42474430
74Malnutrition (HP:0004395)2.42453405
75Arterial thrombosis (HP:0004420)2.42411277
76Inflammation of the large intestine (HP:0002037)2.41835160
77Pulmonary infiltrates (HP:0002113)2.41629539
78Fragile nails (HP:0001808)2.40611868
79Gastrointestinal inflammation (HP:0004386)2.39331358
80Aplasia/Hypoplasia of the earlobes (HP:0009906)2.39198687
81Overfolded helix (HP:0000396)2.38238588
82Abnormality of T cell number (HP:0011839)2.35770004
83Chronic mucocutaneous candidiasis (HP:0002728)2.31770708
84Recurrent cutaneous fungal infections (HP:0011370)2.31770708
85Anorexia (HP:0002039)2.31386868
86Chest pain (HP:0100749)2.30618016
87Gingival bleeding (HP:0000225)2.29603355
88Colitis (HP:0002583)2.27596473
89Progressive muscle weakness (HP:0003323)2.27245217
90Recurrent viral infections (HP:0004429)2.25804123
91Loss of speech (HP:0002371)2.25666398
92Plantar hyperkeratosis (HP:0007556)2.25028235
93Chronic otitis media (HP:0000389)2.24778246
94Palmar hyperkeratosis (HP:0010765)2.24466191
95Abnormal number of erythroid precursors (HP:0012131)2.24265181
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23652288
97Abnormally folded helix (HP:0008544)2.23138569
98Segmental peripheral demyelination/remyelination (HP:0003481)2.23041144
99Skin ulcer (HP:0200042)2.21634362
100Myokymia (HP:0002411)2.21363434
101Concave nail (HP:0001598)2.20023621
102Palmoplantar hyperkeratosis (HP:0000972)2.19273349
103Increased IgM level (HP:0003496)2.18625004
104Leukocytosis (HP:0001974)2.18478972
105Prolonged bleeding time (HP:0003010)2.17655092
106Hypergammaglobulinemia (HP:0010702)2.17050130
107Pulmonary embolism (HP:0002204)2.16340820
108Carpal bone hypoplasia (HP:0001498)2.14542247
109Woolly hair (HP:0002224)2.13970580
110Rough bone trabeculation (HP:0100670)2.13916587
111Abnormal blistering of the skin (HP:0008066)2.12816018
112Horseshoe kidney (HP:0000085)2.12575526
113Aplasia/Hypoplasia involving the musculature (HP:0001460)2.11360622
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10913893
115Oral leukoplakia (HP:0002745)2.10530539
116Pallor (HP:0000980)2.07030737
117Hypochromic anemia (HP:0001931)2.06700170
118Fetal akinesia sequence (HP:0001989)2.06032230
119Chromsome breakage (HP:0040012)2.05678230
120Abnormality of the peritoneum (HP:0002585)2.04696941
121Epistaxis (HP:0000421)2.02158538
122Patellar aplasia (HP:0006443)2.01987833
123Sepsis (HP:0100806)2.01608496
124Osteomyelitis (HP:0002754)1.96810729
125Abnormality of glycosphingolipid metabolism (HP:0004343)1.95986784
126Abnormality of glycolipid metabolism (HP:0010969)1.95986784
127Abnormality of liposaccharide metabolism (HP:0010968)1.95986784
128Pendular nystagmus (HP:0012043)1.95361515
129Abnormality of the pleura (HP:0002103)1.95258699
130Slow saccadic eye movements (HP:0000514)1.94123684
131Pili torti (HP:0003777)1.93888678
132Hypochromic microcytic anemia (HP:0004840)1.93460054
133Subacute progressive viral hepatitis (HP:0006572)1.91899092
134Aplasia/Hypoplasia of the patella (HP:0006498)1.91686076
135Recurrent bronchitis (HP:0002837)1.91163792
136Polygenic inheritance (HP:0010982)1.90159315
137Fibular aplasia (HP:0002990)1.89582580
138Acne (HP:0001061)1.89525249
139Clubbing of toes (HP:0100760)1.89196129
140Obstructive sleep apnea (HP:0002870)1.89085340
141Colon cancer (HP:0003003)1.87899790
142Recurrent sinusitis (HP:0011108)1.86830657
143Increased cerebral lipofuscin (HP:0011813)1.86482005
144Onycholysis (HP:0001806)1.86474720
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85465909
146Autoimmune thrombocytopenia (HP:0001973)1.85068268
147Metaphyseal cupping (HP:0003021)1.84969242
148Systemic lupus erythematosus (HP:0002725)1.84691439
149Cheilitis (HP:0100825)1.84587624
150Selective tooth agenesis (HP:0001592)1.84587314
151Nail dystrophy (HP:0008404)1.83821070
152Hypotrichosis (HP:0001006)1.82189235
153Abnormality of the endocardium (HP:0004306)1.81692015
154Keratitis (HP:0000491)1.80834424
155Glomerulopathy (HP:0100820)1.80442080
156Upper limb muscle weakness (HP:0003484)1.79838825
157Trismus (HP:0000211)1.79617050
158Abnormality of T cells (HP:0002843)1.78371283
159Absent thumb (HP:0009777)1.78038522
160Aplasia/Hypoplasia of the breasts (HP:0010311)1.77230768
161Breast aplasia (HP:0100783)1.75476996
162Parakeratosis (HP:0001036)1.75057975
163Granulocytopenia (HP:0001913)1.74925818
164Abnormality of the pericardium (HP:0001697)1.74002258
165Distal lower limb muscle weakness (HP:0009053)1.73753409
166Absent toe (HP:0010760)1.73738523
167Increased serum ferritin (HP:0003281)1.73725198
168Abnormality of abdominal situs (HP:0011620)1.73577499
169Abdominal situs inversus (HP:0003363)1.73577499
170Autoimmune hemolytic anemia (HP:0001890)1.72857149
171Abnormality of the axillary hair (HP:0100134)1.72209176
172Abnormality of secondary sexual hair (HP:0009888)1.72209176
173Ulnar claw (HP:0001178)1.71807090
174Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69445388
175Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69445388
176Increased number of teeth (HP:0011069)1.68688328
177Supernumerary spleens (HP:0009799)1.68553681
178Delusions (HP:0000746)1.68430515
179Aplasia/hypoplasia of the uterus (HP:0008684)1.67054439
180Sparse eyelashes (HP:0000653)1.66709004
181Stenosis of the external auditory canal (HP:0000402)1.65362151
182Amyotrophic lateral sclerosis (HP:0007354)1.63888239
183CNS hypomyelination (HP:0003429)1.61650691
184Oligodactyly (HP:0012165)1.60876167
185Supernumerary bones of the axial skeleton (HP:0009144)1.60859820
186Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.60698806
187Large hands (HP:0001176)1.60145156
188Tetralogy of Fallot (HP:0001636)1.58634568
189Depressed nasal ridge (HP:0000457)1.58589913
190Exercise intolerance (HP:0003546)1.58173178
191Amniotic constriction ring (HP:0009775)1.57125194
192Abnormality of placental membranes (HP:0011409)1.57125194
193Meckel diverticulum (HP:0002245)1.57104442
194Spinal cord compression (HP:0002176)1.56298740
195Abnormality of the preputium (HP:0100587)1.54407892
196Triphalangeal thumb (HP:0001199)1.54280692
197Aplasia/Hypoplasia of the sacrum (HP:0008517)1.54129012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.39087349
2IRAK34.14280049
3BUB13.68716973
4RIPK43.65399007
5PLK43.51797442
6MAP4K13.10732570
7ERN12.93801370
8EPHA22.92993144
9WEE12.78756931
10EPHB12.78091677
11STK162.69268405
12CSK2.67145894
13BLK2.65561093
14TYK22.65193271
15PNCK2.49577481
16MAP2K32.45946871
17PRPF4B2.40532819
18TESK22.17508569
19MAP3K32.14492370
20ZAP702.09346701
21LATS22.09008980
22IRAK22.08571578
23TAOK11.97847167
24ZAK1.97533855
25RIPK11.96786456
26MAP3K141.93055824
27TTK1.92543793
28MAP3K91.90017564
29JAK31.84162900
30TRIB31.81357009
31FGR1.80972018
32NME11.80373811
33RPS6KB21.78480418
34EIF2AK11.77024931
35LIMK11.75528507
36FES1.74923057
37NEK11.72850002
38MAPKAPK31.72292252
39IKBKE1.69672119
40GRK61.69207716
41PRKCI1.65592031
42NTRK31.64343839
43FGFR41.63119807
44TBK11.61081250
45MATK1.52616447
46TNK21.51668025
47CDC71.49527892
48SRPK11.47222505
49HCK1.46480914
50DYRK31.45398910
51SMG11.39130947
52MAP3K11.38043419
53TESK11.37616117
54PLK11.36351810
55IRAK11.33879872
56DYRK21.33730879
57BTK1.33379287
58EPHA41.32105179
59TXK1.31269389
60PAK41.30986876
61MAP3K131.30941465
62EPHA31.29607899
63JAK11.29413700
64SIK31.26813500
65SIK11.26184126
66JAK21.24833281
67TSSK61.23057193
68EIF2AK31.21928601
69MAP3K61.21141485
70MINK11.17799001
71PTK61.16685254
72CDK121.13679150
73TLK11.12969679
74PLK31.10670192
75IRAK41.08874537
76AURKA1.07119348
77FER1.05611967
78LYN1.05233522
79SYK1.02252039
80TAOK21.00433527
81ALK0.99750775
82FGFR30.99204100
83TGFBR20.99095248
84LCK0.97780183
85TNIK0.92627782
86NTRK20.91373326
87PRKD20.91053036
88YES10.89073619
89IKBKB0.88807773
90SIK20.83807156
91CSF1R0.78111380
92LMTK20.77562587
93STK38L0.77516282
94AKT30.76362349
95CSNK1E0.75453714
96MAP3K120.74901661
97NEK60.74668564
98MST40.74454913
99ATR0.74410357
100VRK10.74310702
101ITK0.72621149
102CHEK20.71896943
103STK380.71784116
104STK100.70299879
105CHEK10.69223173
106CAMK2B0.68735991
107BRD40.66413073
108LRRK20.65997672
109NLK0.65851904
110PLK20.64729894
111HIPK20.64407356
112BCR0.64126559
113RET0.64062160
114MAPK150.63019445
115DYRK1B0.62876988
116MAP3K70.62384901
117MAP3K80.62383247
118FYN0.61183754
119MAPK70.60623352
120PDPK10.60020593
121CDK140.58860968
122* CDC42BPA0.57864771
123PHKG20.57728778
124PHKG10.57728778
125CDK70.57125522
126PDGFRB0.56358255
127MARK30.56338607
128CDK150.56073568
129MAP3K50.56018248
130PDK10.55967058
131MAP3K20.55454654
132CDK11A0.55428426
133PAK10.55394913
134AURKB0.54712658
135ICK0.53416595
136CHUK0.53182975
137SGK30.52734965
138PKN20.52515048
139CDK180.52505219
140MAP2K60.51795673
141ACVR1B0.50917590
142PBK0.50453723
143TAOK30.49139694
144PAK60.47906296
145STK240.47846104
146ABL20.47643392
147BMPR20.47502195
148KIT0.47493603
149EPHB20.47153173
150PTK2B0.46849151
151CSNK2A20.46085462
152RPS6KL10.45900988
153RPS6KC10.45900988
154BMX0.45230351
155MAPK130.44313127
156ATM0.43579938
157KSR20.43370605
158GRK70.42790633
159CDK20.42238550
160RPS6KA20.42077415
161CDK10.41845639
162UHMK10.41711157
163EIF2AK20.40900272
164BRSK10.40312011
165NEK20.40311925
166MAP3K40.40097259
167CAMK2G0.39510210
168CAMK2D0.38897577
169KSR10.38694828
170CDK190.38553680
171MARK20.37285423
172PIM10.35092335
173SCYL20.35056658
174PRKDC0.34859429
175MAPK120.33794189
176RPS6KA60.33538918
177PDGFRA0.33421969
178MAPKAPK20.33382571
179MAP2K40.33214240
180DAPK30.32671920
181MAP3K110.32253528
182DYRK1A0.31803762
183CSNK2A10.31242151
184CAMK2A0.30930048
185GRK50.30613866
186TYRO30.30596765
187CSNK1G30.29948130

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.67163325
2RNA polymerase_Homo sapiens_hsa030203.60980177
3DNA replication_Homo sapiens_hsa030303.02884255
4Proteasome_Homo sapiens_hsa030503.00481252
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95078816
6Mismatch repair_Homo sapiens_hsa034302.86065742
7Osteoclast differentiation_Homo sapiens_hsa043802.72558016
8Spliceosome_Homo sapiens_hsa030402.70236725
9Leishmaniasis_Homo sapiens_hsa051402.55872563
10Phototransduction_Homo sapiens_hsa047442.48240469
11Fanconi anemia pathway_Homo sapiens_hsa034602.47485362
12Oxidative phosphorylation_Homo sapiens_hsa001902.40112365
13Pyrimidine metabolism_Homo sapiens_hsa002402.35458950
14Staphylococcus aureus infection_Homo sapiens_hsa051502.23839209
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18553408
16RNA transport_Homo sapiens_hsa030132.16959376
17Parkinsons disease_Homo sapiens_hsa050122.15567197
18Huntingtons disease_Homo sapiens_hsa050162.02453878
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97928788
20Nucleotide excision repair_Homo sapiens_hsa034201.95968750
21Tuberculosis_Homo sapiens_hsa051521.94450515
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92105988
23Malaria_Homo sapiens_hsa051441.91454190
24B cell receptor signaling pathway_Homo sapiens_hsa046621.91151606
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84910383
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.80838517
27Homologous recombination_Homo sapiens_hsa034401.79918100
28Acute myeloid leukemia_Homo sapiens_hsa052211.78345524
29Nicotine addiction_Homo sapiens_hsa050331.77793449
30* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75928455
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75419730
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75384444
33TNF signaling pathway_Homo sapiens_hsa046681.67020675
34Toxoplasmosis_Homo sapiens_hsa051451.64129289
35Allograft rejection_Homo sapiens_hsa053301.63748646
36Measles_Homo sapiens_hsa051621.63442748
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62616832
38Graft-versus-host disease_Homo sapiens_hsa053321.59518625
39Influenza A_Homo sapiens_hsa051641.59066671
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57557159
41Synaptic vesicle cycle_Homo sapiens_hsa047211.56337355
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53514665
43Basal transcription factors_Homo sapiens_hsa030221.52605165
44Chemokine signaling pathway_Homo sapiens_hsa040621.52508593
45Alzheimers disease_Homo sapiens_hsa050101.51659916
46Legionellosis_Homo sapiens_hsa051341.51078667
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50908127
48Purine metabolism_Homo sapiens_hsa002301.49901677
49Hepatitis C_Homo sapiens_hsa051601.47018945
50Oocyte meiosis_Homo sapiens_hsa041141.46498138
51T cell receptor signaling pathway_Homo sapiens_hsa046601.44451354
52Autoimmune thyroid disease_Homo sapiens_hsa053201.43839818
53Cell cycle_Homo sapiens_hsa041101.43560805
54Other glycan degradation_Homo sapiens_hsa005111.38251831
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.36778397
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.36078368
57p53 signaling pathway_Homo sapiens_hsa041151.35559955
58African trypanosomiasis_Homo sapiens_hsa051431.30735455
59Hematopoietic cell lineage_Homo sapiens_hsa046401.30578891
60Pertussis_Homo sapiens_hsa051331.30098222
61Cardiac muscle contraction_Homo sapiens_hsa042601.28266754
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26432852
63mRNA surveillance pathway_Homo sapiens_hsa030151.25722794
64Primary immunodeficiency_Homo sapiens_hsa053401.25254146
65VEGF signaling pathway_Homo sapiens_hsa043701.24892100
66Salmonella infection_Homo sapiens_hsa051321.21783098
67Base excision repair_Homo sapiens_hsa034101.21699281
68Herpes simplex infection_Homo sapiens_hsa051681.18136037
69Hepatitis B_Homo sapiens_hsa051611.17665408
70Notch signaling pathway_Homo sapiens_hsa043301.15471120
71Amoebiasis_Homo sapiens_hsa051461.14801278
72Pancreatic cancer_Homo sapiens_hsa052121.13293583
73Chronic myeloid leukemia_Homo sapiens_hsa052201.13203562
74Phagosome_Homo sapiens_hsa041451.13045357
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13001595
76RNA degradation_Homo sapiens_hsa030181.11455986
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11170026
78Epstein-Barr virus infection_Homo sapiens_hsa051691.09500650
79Non-small cell lung cancer_Homo sapiens_hsa052231.09253529
80Prolactin signaling pathway_Homo sapiens_hsa049171.09064960
81One carbon pool by folate_Homo sapiens_hsa006701.08529905
82Viral myocarditis_Homo sapiens_hsa054161.06854806
83Type I diabetes mellitus_Homo sapiens_hsa049401.06385773
84Cyanoamino acid metabolism_Homo sapiens_hsa004601.04360240
85Antigen processing and presentation_Homo sapiens_hsa046121.03454994
86Shigellosis_Homo sapiens_hsa051311.02842480
87Apoptosis_Homo sapiens_hsa042101.02732850
88Collecting duct acid secretion_Homo sapiens_hsa049661.01952724
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01209326
90Amphetamine addiction_Homo sapiens_hsa050310.97545243
91Renal cell carcinoma_Homo sapiens_hsa052110.93197352
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91267616
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.90540751
94Lysosome_Homo sapiens_hsa041420.89864192
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89570111
96Rheumatoid arthritis_Homo sapiens_hsa053230.88295264
97Hippo signaling pathway_Homo sapiens_hsa043900.87972924
98Tight junction_Homo sapiens_hsa045300.86813337
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85281038
100Platelet activation_Homo sapiens_hsa046110.84907129
101Endometrial cancer_Homo sapiens_hsa052130.82590808
102Endocytosis_Homo sapiens_hsa041440.82272553
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.80804847
104Glutamatergic synapse_Homo sapiens_hsa047240.80709787
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.80686343
106Hedgehog signaling pathway_Homo sapiens_hsa043400.80608057
107Long-term potentiation_Homo sapiens_hsa047200.80116765
108Vibrio cholerae infection_Homo sapiens_hsa051100.79860295
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79824384
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79357933
111Taste transduction_Homo sapiens_hsa047420.78175604
112Basal cell carcinoma_Homo sapiens_hsa052170.78090584
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77417123
114Non-homologous end-joining_Homo sapiens_hsa034500.74999436
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73983205
116Gap junction_Homo sapiens_hsa045400.72888472
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.72465208
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71927606
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.70813225
120GABAergic synapse_Homo sapiens_hsa047270.70692531
121* Axon guidance_Homo sapiens_hsa043600.70652402
122FoxO signaling pathway_Homo sapiens_hsa040680.69301894
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69212324
124Choline metabolism in cancer_Homo sapiens_hsa052310.68167178
125ErbB signaling pathway_Homo sapiens_hsa040120.67719421
126Dopaminergic synapse_Homo sapiens_hsa047280.66802068
127Dorso-ventral axis formation_Homo sapiens_hsa043200.65968421
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65594455
129Insulin resistance_Homo sapiens_hsa049310.62877706
130Long-term depression_Homo sapiens_hsa047300.62529048
131Small cell lung cancer_Homo sapiens_hsa052220.61942832
132Gastric acid secretion_Homo sapiens_hsa049710.61765443
133Melanogenesis_Homo sapiens_hsa049160.61478714
134Inositol phosphate metabolism_Homo sapiens_hsa005620.61364262
135Asthma_Homo sapiens_hsa053100.60109393
136Serotonergic synapse_Homo sapiens_hsa047260.60025116
137Salivary secretion_Homo sapiens_hsa049700.59443099
138HIF-1 signaling pathway_Homo sapiens_hsa040660.59397247
139Wnt signaling pathway_Homo sapiens_hsa043100.58973868
140Circadian entrainment_Homo sapiens_hsa047130.58956103
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58737151
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58548680
143Olfactory transduction_Homo sapiens_hsa047400.57138718
144Cholinergic synapse_Homo sapiens_hsa047250.54090272
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53931907
146mTOR signaling pathway_Homo sapiens_hsa041500.53582123
147Morphine addiction_Homo sapiens_hsa050320.53127393
148Type II diabetes mellitus_Homo sapiens_hsa049300.53088164
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51850909
150Alcoholism_Homo sapiens_hsa050340.51790689
151Rap1 signaling pathway_Homo sapiens_hsa040150.51571682
152GnRH signaling pathway_Homo sapiens_hsa049120.51267950
153Prostate cancer_Homo sapiens_hsa052150.50939374
154Cocaine addiction_Homo sapiens_hsa050300.50576992
155Insulin signaling pathway_Homo sapiens_hsa049100.49280740
156Glutathione metabolism_Homo sapiens_hsa004800.49069268
157MAPK signaling pathway_Homo sapiens_hsa040100.48235350
158Proteoglycans in cancer_Homo sapiens_hsa052050.46977529
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45492750
160Prion diseases_Homo sapiens_hsa050200.43293709
161Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42279029
162Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41394050
163Oxytocin signaling pathway_Homo sapiens_hsa049210.39569803
164Ether lipid metabolism_Homo sapiens_hsa005650.39425593
165Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38863801
166Calcium signaling pathway_Homo sapiens_hsa040200.38817664
167Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36358574
168Insulin secretion_Homo sapiens_hsa049110.36205807
169Linoleic acid metabolism_Homo sapiens_hsa005910.35960492
170Sphingolipid metabolism_Homo sapiens_hsa006000.35800034
171Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35169766
172Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31992374
173Estrogen signaling pathway_Homo sapiens_hsa049150.31848428
174TGF-beta signaling pathway_Homo sapiens_hsa043500.29049520
175Colorectal cancer_Homo sapiens_hsa052100.28825527
176Ras signaling pathway_Homo sapiens_hsa040140.25722014
177HTLV-I infection_Homo sapiens_hsa051660.23760762
178Pathways in cancer_Homo sapiens_hsa052000.23008079
179Thyroid cancer_Homo sapiens_hsa052160.22213012
180Arginine and proline metabolism_Homo sapiens_hsa003300.22159564
181Viral carcinogenesis_Homo sapiens_hsa052030.21453533
182Bladder cancer_Homo sapiens_hsa052190.20767617
183Sphingolipid signaling pathway_Homo sapiens_hsa040710.20187712
184MicroRNAs in cancer_Homo sapiens_hsa052060.19806645
185Renin secretion_Homo sapiens_hsa049240.19695248
186Renin-angiotensin system_Homo sapiens_hsa046140.19215048
187Melanoma_Homo sapiens_hsa052180.19164634

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