LIMS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.95251823
2regulation of platelet activation (GO:0010543)5.44173250
3regulation of platelet aggregation (GO:0090330)5.25815704
4protein neddylation (GO:0045116)4.82914199
5positive regulation of mast cell activation (GO:0033005)4.65247236
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.63607733
7regulation of integrin activation (GO:0033623)4.55818866
8adenosine receptor signaling pathway (GO:0001973)4.49241664
9negative regulation of platelet activation (GO:0010544)4.42669350
10negative regulation of homotypic cell-cell adhesion (GO:0034111)4.32643875
11negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.30201506
12endothelium development (GO:0003158)4.24702245
13leukocyte migration involved in inflammatory response (GO:0002523)4.24435067
14neutrophil activation involved in immune response (GO:0002283)3.83761167
15lipoxygenase pathway (GO:0019372)3.76271749
16platelet degranulation (GO:0002576)3.68047506
17megakaryocyte development (GO:0035855)3.66710052
18negative regulation of norepinephrine secretion (GO:0010700)3.62459393
19blood coagulation, intrinsic pathway (GO:0007597)3.61665309
20positive regulation of receptor recycling (GO:0001921)3.61100970
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.59096689
22regulation of mast cell activation (GO:0033003)3.52729041
23modulation by symbiont of host immune response (GO:0052553)3.46374285
24positive regulation by symbiont of host defense response (GO:0052509)3.46374285
25modulation by symbiont of host defense response (GO:0052031)3.46374285
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46374285
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46374285
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.46374285
29regulation of macrophage derived foam cell differentiation (GO:0010743)3.45834632
30G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.45715809
31positive regulation of hemostasis (GO:1900048)3.45680240
32positive regulation of blood coagulation (GO:0030194)3.45680240
33cellular response to thyroid hormone stimulus (GO:0097067)3.41891447
34regulation of homotypic cell-cell adhesion (GO:0034110)3.38361626
35regulation of mast cell degranulation (GO:0043304)3.37467193
36positive regulation of endothelial cell differentiation (GO:0045603)3.37295305
37cell adhesion mediated by integrin (GO:0033627)3.35202154
38positive regulation of mast cell degranulation (GO:0043306)3.30743448
39positive regulation of mast cell activation involved in immune response (GO:0033008)3.30743448
40platelet activation (GO:0030168)3.29504656
41regulation of interferon-beta biosynthetic process (GO:0045357)3.27800917
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26760846
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26760846
44regulation of mast cell activation involved in immune response (GO:0033006)3.23531494
45phagocytosis, engulfment (GO:0006911)3.22389782
46low-density lipoprotein particle remodeling (GO:0034374)3.19477736
47positive regulation of coagulation (GO:0050820)3.18643717
48homotypic cell-cell adhesion (GO:0034109)3.18204268
49positive regulation of interferon-alpha production (GO:0032727)3.16595113
50antigen processing and presentation of endogenous antigen (GO:0019883)3.15713018
51platelet formation (GO:0030220)3.13609618
52purinergic nucleotide receptor signaling pathway (GO:0035590)3.13486979
53cellular extravasation (GO:0045123)3.08832815
54regulation of T-helper 1 cell differentiation (GO:0045625)3.07461860
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04099716
56peptide catabolic process (GO:0043171)3.03242295
57response to peptidoglycan (GO:0032494)3.01834579
58negative regulation of T-helper cell differentiation (GO:0045623)3.00719378
59negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00719378
60regulation of interferon-alpha production (GO:0032647)2.98952538
61negative regulation of thymocyte apoptotic process (GO:0070244)2.92844663
62regulation of lipoprotein metabolic process (GO:0050746)2.92810328
63negative regulation of lipid storage (GO:0010888)2.92399049
64negative regulation of interleukin-17 production (GO:0032700)2.92288511
65negative regulation of cell junction assembly (GO:1901889)2.91749094
66negative regulation of adherens junction organization (GO:1903392)2.91749094
67negative regulation of focal adhesion assembly (GO:0051895)2.91749094
68leukocyte degranulation (GO:0043299)2.89776431
69extracellular fibril organization (GO:0043206)2.85608068
70G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.85308142
71positive regulation of Rho protein signal transduction (GO:0035025)2.85210136
72negative regulation of protein localization to cell surface (GO:2000009)2.84491511
73superoxide anion generation (GO:0042554)2.84064895
74negative regulation of stress fiber assembly (GO:0051497)2.82615972
75purinergic receptor signaling pathway (GO:0035587)2.81272408
76cellular response to zinc ion (GO:0071294)2.81056704
77regulation of blood coagulation (GO:0030193)2.78516739
78regulation of hemostasis (GO:1900046)2.78516739
79autophagic vacuole fusion (GO:0000046)2.78369295
80positive regulation of natural killer cell differentiation (GO:0032825)2.77981358
81positive regulation of leukocyte degranulation (GO:0043302)2.77890643
82positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.77866238
83membrane invagination (GO:0010324)2.77582709
84leukocyte aggregation (GO:0070486)2.74723902
85negative regulation of protein localization to plasma membrane (GO:1903077)2.74337522
86myeloid cell activation involved in immune response (GO:0002275)2.74113061
87regulation of MHC class II biosynthetic process (GO:0045346)2.72873858
88positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.72716674
89positive regulation of gamma-delta T cell activation (GO:0046645)2.72523851
90neutrophil activation (GO:0042119)2.72153376
91positive regulation of systemic arterial blood pressure (GO:0003084)2.71755797
92response to interferon-alpha (GO:0035455)2.71723096
93vascular endothelial growth factor signaling pathway (GO:0038084)2.71701011
94mesodermal cell differentiation (GO:0048333)2.69788865
95cellular response to interferon-alpha (GO:0035457)2.67925073
96endodermal cell differentiation (GO:0035987)2.66286226
97positive regulation of granulocyte differentiation (GO:0030854)2.66015198
98regulation of Golgi to plasma membrane protein transport (GO:0042996)2.65993645
99immunoglobulin mediated immune response (GO:0016064)2.63946902
100cyclooxygenase pathway (GO:0019371)2.63471636
101regulation of leukocyte degranulation (GO:0043300)2.63462994
102fibril organization (GO:0097435)2.63413346
103regulation of T-helper 2 cell differentiation (GO:0045628)2.62719940
104intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.62130748
105regulation of coagulation (GO:0050818)2.61329753
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60845811
107positive regulation of cellular amide metabolic process (GO:0034250)2.60459880
108endothelial tube morphogenesis (GO:0061154)2.59142661
109morphogenesis of an endothelium (GO:0003159)2.59142661
110pinocytosis (GO:0006907)2.58934816
111positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.57405391
112positive regulation of B cell differentiation (GO:0045579)2.57382306
113regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.57278629
114fusion of sperm to egg plasma membrane (GO:0007342)2.57111785
115myeloid cell development (GO:0061515)2.55336938
116macrophage activation involved in immune response (GO:0002281)2.55102629
117negative regulation of phagocytosis (GO:0050765)2.54880960
118regulation of inositol phosphate biosynthetic process (GO:0010919)2.54131618
119substrate-dependent cell migration (GO:0006929)2.54010030
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53630073
121wound healing, spreading of epidermal cells (GO:0035313)2.51988110
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51033695
123granulocyte activation (GO:0036230)2.50497329
124establishment of endothelial barrier (GO:0061028)2.50164910
125regulation of interleukin-12 biosynthetic process (GO:0045075)2.46855381
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.46755726
127positive regulation of chemokine biosynthetic process (GO:0045080)2.46666144
128regulation of B cell receptor signaling pathway (GO:0050855)2.40413301
129response to muramyl dipeptide (GO:0032495)2.36339012
130B cell mediated immunity (GO:0019724)2.36185018
131regulation of necroptotic process (GO:0060544)2.35841390
132lymph vessel development (GO:0001945)2.35134023
133angiogenesis involved in wound healing (GO:0060055)2.34702408
134natural killer cell mediated cytotoxicity (GO:0042267)2.33213329
135natural killer cell mediated immunity (GO:0002228)2.33213329
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32699369
137response to host immune response (GO:0052572)2.32313094
138response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32313094
139positive regulation of macrophage differentiation (GO:0045651)2.32184960
140retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31854853
141response to type I interferon (GO:0034340)2.31070519
142leukocyte cell-cell adhesion (GO:0007159)2.29756572
143lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29680693
144hepatocyte apoptotic process (GO:0097284)2.28277208
145positive regulation of vasculogenesis (GO:2001214)2.27233216
146integrin-mediated signaling pathway (GO:0007229)2.26433297
147membrane raft organization (GO:0031579)2.26180069
148response to laminar fluid shear stress (GO:0034616)2.26119712
149type I interferon signaling pathway (GO:0060337)2.25804591
150cellular response to type I interferon (GO:0071357)2.25804591
151regulation of protein heterodimerization activity (GO:0043497)2.25058678
152definitive hemopoiesis (GO:0060216)2.24657733
153positive regulation of interferon-beta production (GO:0032728)2.24598863
154respiratory burst (GO:0045730)2.23544543
155regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23456014
156response to host (GO:0075136)2.22647158
157response to host defenses (GO:0052200)2.22647158
158response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.22647158
159positive regulation of lamellipodium assembly (GO:0010592)2.21080513
160positive regulation of protein import into nucleus, translocation (GO:0033160)2.20509216
161response to interferon-beta (GO:0035456)2.19835809
162actin nucleation (GO:0045010)2.19820963
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.19094106
164production of molecular mediator involved in inflammatory response (GO:0002532)2.18126661
165cellular response to interferon-beta (GO:0035458)2.17430605
166regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.16172238
167positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.15886312
168wound healing, spreading of cells (GO:0044319)2.14657600
169positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.14545616
170collagen fibril organization (GO:0030199)2.14272154
171germ cell migration (GO:0008354)2.13140259
172positive regulation of endothelial cell apoptotic process (GO:2000353)2.12643072
173interferon-gamma-mediated signaling pathway (GO:0060333)2.12502067
174positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.12467248
175regulation of macrophage cytokine production (GO:0010935)2.10766739
176cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.10708645
177regulation of type I interferon-mediated signaling pathway (GO:0060338)2.10701799
178sequestering of metal ion (GO:0051238)2.10691894
179regulation of chemokine biosynthetic process (GO:0045073)2.09631951
180platelet aggregation (GO:0070527)2.08742227
181positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.07648861
182glomerular filtration (GO:0003094)2.07560648
183apoptotic cell clearance (GO:0043277)2.07505208
184positive regulation of tumor necrosis factor production (GO:0032760)2.07103367
185positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.06684423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.72629770
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07701351
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.06741300
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.98170972
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.60944227
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.57457948
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.40982666
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.29844339
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.24181564
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93730801
11GATA1_19941826_ChIP-Seq_K562_Human2.87337182
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71876652
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65202977
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62897758
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.60541415
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51873045
17GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.50818424
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.50263581
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45785922
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.40419314
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39090246
22* GATA2_19941826_ChIP-Seq_K562_Human2.28110212
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25474893
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21423492
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.19833557
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.17745447
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12753216
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09628149
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05574138
30* GATA1_19941827_ChIP-Seq_MEL_Mouse1.99711636
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98624269
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90623315
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88527909
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.87624581
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85721870
36SPI1_23547873_ChIP-Seq_NB4_Human1.85620777
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83897872
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82828518
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81113715
40MYB_26560356_Chip-Seq_TH2_Human1.79975878
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.79069262
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74643487
43CLOCK_20551151_ChIP-Seq_293T_Human1.73826582
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73066755
45SCL_19346495_ChIP-Seq_HPC-7_Human1.70784881
46MAF_26560356_Chip-Seq_TH1_Human1.63740891
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63672929
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60778566
49VDR_21846776_ChIP-Seq_THP-1_Human1.58973347
50VDR_24763502_ChIP-Seq_THP-1_Human1.57879021
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56521787
52GATA1_22025678_ChIP-Seq_K562_Human1.54896864
53* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53561552
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50886637
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50874426
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50228185
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50228185
58AR_21909140_ChIP-Seq_LNCAP_Human1.50022418
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47422986
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.47201989
61* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46386280
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.46285780
63* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46158386
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.45801296
65RUNX_20019798_ChIP-Seq_JUKART_Human1.45561425
66MYB_26560356_Chip-Seq_TH1_Human1.45506295
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42640369
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41322267
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41322267
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40224297
71MYC_22102868_ChIP-Seq_BL_Human1.40104197
72ELK1_19687146_ChIP-ChIP_HELA_Human1.37055885
73* RUNX1_22412390_ChIP-Seq_EML_Mouse1.35120487
74BRD4_25478319_ChIP-Seq_HGPS_Human1.33553349
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33046960
76PU_27001747_Chip-Seq_BMDM_Mouse1.32934849
77* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.30712966
78* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29962589
79UTX_26944678_Chip-Seq_JUKART_Human1.29625523
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29571872
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28128189
82* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27174950
83* SPI1_23127762_ChIP-Seq_K562_Human1.27059411
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26631683
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23540772
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23250089
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19028226
88* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17930124
89NCOR1_26117541_ChIP-Seq_K562_Human1.17074852
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15231456
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14684049
92CJUN_26792858_Chip-Seq_BT549_Human1.13995311
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.13202988
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.12964263
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11019450
96* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10739142
97VDR_24787735_ChIP-Seq_THP-1_Human1.10417526
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10129929
99TCF7_22412390_ChIP-Seq_EML_Mouse1.09667687
100ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09541944
101* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08829588
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06482880
103GATA3_27048872_Chip-Seq_THYMUS_Human1.06456084
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06406871
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05942405
106TFEB_21752829_ChIP-Seq_HELA_Human1.05195105
107GATA3_26560356_Chip-Seq_TH2_Human1.04760401
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03359911
109NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99525672
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99186701
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98355337
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97552407
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.96630178
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96508855
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95968620
116* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95605487
117KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95569537
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95309660
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94982827
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93399017
121* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92953605
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92874094
123* UBF1/2_26484160_Chip-Seq_HMECs_Human0.92512894
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91648695
125* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90885220
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90343775
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89571463
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87418377
129RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87336201
130* SALL4_22934838_ChIP-ChIP_CD34+_Human0.87292454
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86688375
132SOX2_20726797_ChIP-Seq_SW620_Human0.86565077
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86313335
134ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85013909
135HTT_18923047_ChIP-ChIP_STHdh_Human0.82541416
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79692576
137SPI1_20517297_ChIP-Seq_HL60_Human0.77144008
138* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75205709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH3.96102601
2MP0008438_abnormal_cutaneous_collagen3.65782115
3MP0006054_spinal_hemorrhage2.77928935
4MP0001835_abnormal_antigen_presentation2.48734397
5MP0003279_aneurysm2.48650034
6MP0010352_gastrointestinal_tract_polyps2.16951076
7MP0003705_abnormal_hypodermis_morpholog2.13012587
8MP0009785_altered_susceptibility_to2.09046814
9MP0003566_abnormal_cell_adhesion2.01273773
10MP0001958_emphysema2.00786162
11MP0005275_abnormal_skin_tensile1.96121768
12MP0003436_decreased_susceptibility_to1.92104591
13MP0001879_abnormal_lymphatic_vessel1.90393101
14MP0003300_gastrointestinal_ulcer1.87213099
15MP0005503_abnormal_tendon_morphology1.84347569
16MP0009278_abnormal_bone_marrow1.82380524
17MP0002166_altered_tumor_susceptibility1.82034683
18MP0003724_increased_susceptibility_to1.80260020
19MP0000685_abnormal_immune_system1.80137153
20MP0004272_abnormal_basement_membrane1.78483399
21MP0003303_peritoneal_inflammation1.74410579
22MP0002419_abnormal_innate_immunity1.70089548
23MP0004808_abnormal_hematopoietic_stem1.66141309
24MP0002396_abnormal_hematopoietic_system1.63736964
25MP0002148_abnormal_hypersensitivity_rea1.61486936
26MP0010368_abnormal_lymphatic_system1.59486537
27MP0002006_tumorigenesis1.59017495
28MP0003656_abnormal_erythrocyte_physiolo1.58334113
29MP0004084_abnormal_cardiac_muscle1.54902927
30MP0005000_abnormal_immune_tolerance1.54655096
31MP0002452_abnormal_antigen_presenting1.52617233
32MP0004036_abnormal_muscle_relaxation1.51183751
33MP0001545_abnormal_hematopoietic_system1.50610026
34MP0005397_hematopoietic_system_phenotyp1.50610026
35MP0000767_abnormal_smooth_muscle1.49650268
36* MP0000343_altered_response_to1.48907870
37MP0005025_abnormal_response_to1.47388302
38MP0003091_abnormal_cell_migration1.46114409
39MP0001533_abnormal_skeleton_physiology1.45255685
40MP0001851_eye_inflammation1.44476104
41MP0010307_abnormal_tumor_latency1.44146257
42MP0005023_abnormal_wound_healing1.43324266
43MP0005671_abnormal_response_to1.43191633
44MP0000230_abnormal_systemic_arterial1.40359566
45MP0003448_altered_tumor_morphology1.40106115
46MP0005623_abnormal_meninges_morphology1.39883393
47* MP0003828_pulmonary_edema1.37902200
48MP0003191_abnormal_cellular_cholesterol1.37225476
49MP0004130_abnormal_muscle_cell1.35434483
50MP0001800_abnormal_humoral_immune1.34262425
51MP0001790_abnormal_immune_system1.33923581
52MP0005387_immune_system_phenotype1.33923581
53MP0001819_abnormal_immune_cell1.33579221
54MP0002420_abnormal_adaptive_immunity1.32666273
55MP0001853_heart_inflammation1.30739301
56MP0009333_abnormal_splenocyte_physiolog1.29678379
57MP0002405_respiratory_system_inflammati1.27465592
58MP0000733_abnormal_muscle_development1.27318221
59MP0002723_abnormal_immune_serum1.26907355
60MP0000858_altered_metastatic_potential1.25705634
61MP0003172_abnormal_lysosome_physiology1.25397469
62MP0005165_increased_susceptibility_to1.23573020
63MP0003075_altered_response_to1.23525427
64MP0009763_increased_sensitivity_to1.22975886
65MP0005084_abnormal_gallbladder_morpholo1.22475588
66MP0009384_cardiac_valve_regurgitation1.21998272
67MP0005464_abnormal_platelet_physiology1.21764426
68MP0006082_CNS_inflammation1.19988790
69MP0005076_abnormal_cell_differentiation1.18410073
70MP0002398_abnormal_bone_marrow1.15171260
71MP0004947_skin_inflammation1.15036200
72MP0002877_abnormal_melanocyte_morpholog1.12211481
73MP0009840_abnormal_foam_cell1.12049738
74MP0004883_abnormal_blood_vessel1.10072150
75MP0010155_abnormal_intestine_physiology1.09577158
76MP0001663_abnormal_digestive_system1.08850255
77MP0002933_joint_inflammation1.08438199
78MP0000465_gastrointestinal_hemorrhage1.07886249
79MP0003950_abnormal_plasma_membrane1.06907615
80MP0005167_abnormal_blood-brain_barrier1.06757894
81MP0005058_abnormal_lysosome_morphology1.06475579
82MP0005083_abnormal_biliary_tract1.05229172
83MP0001915_intracranial_hemorrhage1.03926663
84MP0000716_abnormal_immune_system1.03433342
85MP0005390_skeleton_phenotype1.02867407
86MP0001845_abnormal_inflammatory_respons1.00592987
87* MP0010630_abnormal_cardiac_muscle0.98589691
88MP0002998_abnormal_bone_remodeling0.96296662
89MP0002128_abnormal_blood_circulation0.95537627
90MP0000750_abnormal_muscle_regeneration0.95246415
91MP0008775_abnormal_heart_ventricle0.94915011
92MP0000015_abnormal_ear_pigmentation0.94872608
93MP0005595_abnormal_vascular_smooth0.94638393
94MP0004484_altered_response_of0.94585382
95MP0002429_abnormal_blood_cell0.94339407
96MP0002722_abnormal_immune_system0.94035304
97MP0003763_abnormal_thymus_physiology0.93955935
98MP0003638_abnormal_response/metabolism_0.93768722
99MP0003567_abnormal_fetal_cardiomyocyte0.93471003
100MP0008007_abnormal_cellular_replicative0.93390198
101MP0004510_myositis0.92075458
102MP0005166_decreased_susceptibility_to0.90932284
103MP0000689_abnormal_spleen_morphology0.90789615
104* MP0000249_abnormal_blood_vessel0.86934749
105MP0003453_abnormal_keratinocyte_physiol0.86816822
106MP0002925_abnormal_cardiovascular_devel0.86241240
107MP0005164_abnormal_response_to0.86028014
108* MP0001614_abnormal_blood_vessel0.84935801
109MP0002132_abnormal_respiratory_system0.84117226
110MP0008469_abnormal_protein_level0.83880108
111MP0009764_decreased_sensitivity_to0.80700866
112MP0002295_abnormal_pulmonary_circulatio0.80617083
113MP0000490_abnormal_crypts_of0.79859932
114MP0009765_abnormal_xenobiotic_induced0.79657884
115MP0005410_abnormal_fertilization0.77908653
116MP0005409_darkened_coat_color0.77548382
117MP0010234_abnormal_vibrissa_follicle0.76547356
118MP0002060_abnormal_skin_morphology0.76538341
119* MP0001544_abnormal_cardiovascular_syste0.75866115
120* MP0005385_cardiovascular_system_phenoty0.75866115
121MP0005508_abnormal_skeleton_morphology0.74854485
122MP0003795_abnormal_bone_structure0.74339653
123MP0008874_decreased_physiological_sensi0.73862303
124MP0000703_abnormal_thymus_morphology0.72636573
125MP0003806_abnormal_nucleotide_metabolis0.71045256
126MP0002332_abnormal_exercise_endurance0.70370416
127MP0001243_abnormal_dermal_layer0.70181284
128* MP0002972_abnormal_cardiac_muscle0.70079519
129MP0001873_stomach_inflammation0.69999810
130MP0003045_fibrosis0.69376738
131MP0005381_digestive/alimentary_phenotyp0.68800632
132MP0009697_abnormal_copulation0.67804793
133MP0010329_abnormal_lipoprotein_level0.65238741
134MP0005666_abnormal_adipose_tissue0.64755757

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.49405508
2Menorrhagia (HP:0000132)8.11125229
3Purpura (HP:0000979)7.26116012
4Epistaxis (HP:0000421)6.65925008
5Gingival bleeding (HP:0000225)5.65486336
6Impaired platelet aggregation (HP:0003540)5.32919298
7Abnormal platelet function (HP:0011869)5.32919298
8Hyperlipoproteinemia (HP:0010980)4.24922095
9Abnormality of the vasculature of the conjunctiva (HP:0008054)4.02459382
10Recurrent abscess formation (HP:0002722)3.96402802
11Conjunctival telangiectasia (HP:0000524)3.93152452
12Protrusio acetabuli (HP:0003179)3.80678293
13Eczematoid dermatitis (HP:0000976)3.79793008
14Premature rupture of membranes (HP:0001788)3.68754527
15Hematochezia (HP:0002573)3.63417529
16Osteolytic defects of the phalanges of the hand (HP:0009771)3.33645128
17Osteolytic defects of the hand bones (HP:0009699)3.33645128
18Aortic aneurysm (HP:0004942)3.27032856
19Aortic dissection (HP:0002647)3.24660910
20Bruising susceptibility (HP:0000978)3.24147903
21Recurrent bacterial skin infections (HP:0005406)3.21956645
22Myocardial infarction (HP:0001658)3.14738056
23Vacuolated lymphocytes (HP:0001922)3.14113543
24Poikilocytosis (HP:0004447)3.12551506
25Cerebral aneurysm (HP:0004944)3.03284239
26Abnormality of the common coagulation pathway (HP:0010990)3.00760410
27Dyschromatopsia (HP:0007641)2.99916766
28Ankle contracture (HP:0006466)2.97150926
29Cervical subluxation (HP:0003308)2.96540710
30Acanthocytosis (HP:0001927)2.94648610
31Stomatitis (HP:0010280)2.93351302
32Paralysis (HP:0003470)2.92326764
33Myositis (HP:0100614)2.87300919
34Dysostosis multiplex (HP:0000943)2.85732369
35Peritonitis (HP:0002586)2.84756641
36Abnormality of glycolipid metabolism (HP:0010969)2.79623164
37Abnormality of liposaccharide metabolism (HP:0010968)2.79623164
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.79623164
39Hepatosplenomegaly (HP:0001433)2.77649877
40Elevated erythrocyte sedimentation rate (HP:0003565)2.70372806
41Polycythemia (HP:0001901)2.69732873
42Spontaneous hematomas (HP:0007420)2.57561220
43Dilatation of the ascending aorta (HP:0005111)2.53765594
44Abnormality of macrophages (HP:0004311)2.51427058
45Abnormality of iron homeostasis (HP:0011031)2.49716824
46Autoimmune thrombocytopenia (HP:0001973)2.49139084
47Soft skin (HP:0000977)2.46962321
48Cellulitis (HP:0100658)2.40460433
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.38125869
50Tinnitus (HP:0000360)2.37450016
51Vertebral compression fractures (HP:0002953)2.35130942
52Increased connective tissue (HP:0009025)2.33166861
53Shallow orbits (HP:0000586)2.32327137
54Orchitis (HP:0100796)2.31217846
55Syringomyelia (HP:0003396)2.28830960
56Spinal cord lesions (HP:0100561)2.28830960
57Increased serum ferritin (HP:0003281)2.28090435
58Interstitial pulmonary disease (HP:0006530)2.24196290
59Increased density of long bones (HP:0006392)2.24100010
60Abnormal pupillary function (HP:0007686)2.24075878
61Abnormality of transition element cation homeostasis (HP:0011030)2.23656066
62Asymmetry of the thorax (HP:0001555)2.22407198
63Joint swelling (HP:0001386)2.21673121
64Mediastinal lymphadenopathy (HP:0100721)2.19958520
65Vascular tortuosity (HP:0004948)2.19383819
66Short 4th metacarpal (HP:0010044)2.18189304
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18189304
68Recurrent viral infections (HP:0004429)2.14427011
69Wormian bones (HP:0002645)2.13871765
70Xanthomatosis (HP:0000991)2.12649555
71Bicuspid aortic valve (HP:0001647)2.12078008
72Broad metatarsal (HP:0001783)2.12022672
73Nausea (HP:0002018)2.10855355
74Recurrent fungal infections (HP:0002841)2.10163186
75Thrombocytosis (HP:0001894)2.09089708
76Spondylolisthesis (HP:0003302)2.07912954
77Atrophic scars (HP:0001075)2.06425377
78Recurrent gram-negative bacterial infections (HP:0005420)2.03382615
79Abnormality of the peritoneum (HP:0002585)2.03027856
80Mitral valve prolapse (HP:0001634)2.02442301
81Arterial tortuosity (HP:0005116)2.02376426
82Arterial thrombosis (HP:0004420)2.01932682
83Cerebral hemorrhage (HP:0001342)2.01703241
84Upper limb muscle weakness (HP:0003484)2.01329216
85Autoimmune hemolytic anemia (HP:0001890)2.00983234
86Subacute progressive viral hepatitis (HP:0006572)2.00877543
87Persistence of primary teeth (HP:0006335)2.00138865
88Increased cerebral lipofuscin (HP:0011813)1.98483318
89Abnormality of lateral ventricle (HP:0030047)1.97561489
90Bladder diverticulum (HP:0000015)1.97424278
91Broad face (HP:0000283)1.95102414
92Abnormality of the prostate (HP:0008775)1.94447366
93Osteomyelitis (HP:0002754)1.93763693
94Gingivitis (HP:0000230)1.92058053
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.91775748
96Chronic otitis media (HP:0000389)1.90220589
97Abnormal platelet volume (HP:0011876)1.90127246
98Amaurosis fugax (HP:0100576)1.89905981
99Cutaneous melanoma (HP:0012056)1.89003251
100Joint hemorrhage (HP:0005261)1.88955943
101Retrobulbar optic neuritis (HP:0100654)1.88415695
102Optic neuritis (HP:0100653)1.88415695
103Increased IgM level (HP:0003496)1.87111737
104Recurrent skin infections (HP:0001581)1.86685500
105Radial bowing (HP:0002986)1.86484315
106Basal ganglia calcification (HP:0002135)1.86000111
107Increased mean platelet volume (HP:0011877)1.85982653
108Camptodactyly of toe (HP:0001836)1.84653181
109Biconcave vertebral bodies (HP:0004586)1.83848002
110Wrist flexion contracture (HP:0001239)1.82963790
111Blue sclerae (HP:0000592)1.82809785
112Type 1 muscle fiber predominance (HP:0003803)1.82684893
113Encephalitis (HP:0002383)1.81871203
114Papillary thyroid carcinoma (HP:0002895)1.81149627
115Absent frontal sinuses (HP:0002688)1.81102526
116Vertigo (HP:0002321)1.80721454
117Abnormality of the calcaneus (HP:0008364)1.80348853
118Chest pain (HP:0100749)1.78965652
119Mucosal telangiectasiae (HP:0100579)1.77695039
120Nonimmune hydrops fetalis (HP:0001790)1.77314972
121Joint contractures involving the joints of the feet (HP:0100492)1.77020059
122Flexion contracture of toe (HP:0005830)1.77020059
123Leukocytosis (HP:0001974)1.76834342
124Tetraparesis (HP:0002273)1.76821821
125Delayed closure of the anterior fontanelle (HP:0001476)1.76418990
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76373349
127Aneurysm (HP:0002617)1.74864735
128Mitral regurgitation (HP:0001653)1.74745114
129Mitral stenosis (HP:0001718)1.74154118
130Eosinophilia (HP:0001880)1.71708113
131Genu recurvatum (HP:0002816)1.70534689
132T lymphocytopenia (HP:0005403)1.70523839
133Periodontitis (HP:0000704)1.70357482
134Muscle fibrillation (HP:0010546)1.69857172
135Petechiae (HP:0000967)1.69523528
136Spinal rigidity (HP:0003306)1.69143728
137Cerebral ischemia (HP:0002637)1.68147440
138Abnormal auditory evoked potentials (HP:0006958)1.67798025
139Lipoatrophy (HP:0100578)1.66966160
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.66771064
141Obstructive lung disease (HP:0006536)1.66373305
142Chronic obstructive pulmonary disease (HP:0006510)1.66373305
143Portal hypertension (HP:0001409)1.65471963
144Tongue fasciculations (HP:0001308)1.62577326
145Vasculitis (HP:0002633)1.61282528
146Episodic fever (HP:0001954)1.60628724
147Distal lower limb amyotrophy (HP:0008944)1.60450711
148Fragile skin (HP:0001030)1.60378855
149Ulnar bowing (HP:0003031)1.60362351
150Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59317614
151Follicular hyperkeratosis (HP:0007502)1.58531977
152Emphysema (HP:0002097)1.57865553
153Thrombophlebitis (HP:0004418)1.57738564
154Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.57344595
155Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.56979326
156Systemic lupus erythematosus (HP:0002725)1.56821398
157Acute myeloid leukemia (HP:0004808)1.56664873
158High pitched voice (HP:0001620)1.56092009
159Abnormality of T cell number (HP:0011839)1.55033649
160Skin ulcer (HP:0200042)1.54644240
161Abnormality of the pericardium (HP:0001697)1.54231873
162Loss of speech (HP:0002371)1.53098056
163Generalized aminoaciduria (HP:0002909)1.51021899
164Arthralgia (HP:0002829)1.46826701
165Male infertility (HP:0003251)1.46685134
166Abnormality of the hepatic vasculature (HP:0006707)1.46547627
167Esophageal varix (HP:0002040)1.46323606
168Decreased central vision (HP:0007663)1.45072497
169Abnormality of skeletal muscle fiber size (HP:0012084)1.44777695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.37367683
2TTN3.49142424
3BMX2.80677505
4TAOK32.46659059
5TGFBR22.25448016
6PTK2B2.11189578
7KDR2.10488119
8PKN22.10265700
9TRIB32.06071816
10BMPR22.05627865
11NEK92.05241338
12LRRK22.04226514
13JAK32.01997114
14MAP3K141.97851644
15TYK21.90273844
16STK101.90059408
17TBK11.88966431
18MAP4K11.86437403
19FGR1.86026095
20KIT1.82902854
21TGFBR11.76528615
22RPS6KA41.74729500
23FES1.71105428
24TIE11.70748487
25TRPM71.65818568
26PAK41.61280427
27SCYL21.54790137
28TEC1.52110673
29EPHB11.48250232
30NME21.44778764
31PTK61.43709248
32FLT31.43468410
33CSF1R1.38368833
34STK41.37773714
35MAP2K31.32721153
36ADRBK21.32006053
37FGFR31.31553348
38FRK1.27690888
39TESK11.27590903
40JAK11.25567500
41MYLK1.25295587
42IRAK41.24766368
43MAPKAPK31.23790517
44STK31.22266375
45DMPK1.21957101
46ZAP701.20171612
47IKBKB1.19402383
48PDGFRA1.19363507
49LATS11.19183126
50ERN11.16342586
51NUAK11.15206583
52EPHA31.12826597
53EEF2K1.12472546
54BTK1.10868450
55IKBKE1.08639527
56PIM21.07843511
57CSK1.07176586
58ITK1.06824298
59IRAK11.06206454
60CDK61.02738026
61CHUK0.98262894
62CAMKK20.97434199
63BLK0.96846402
64TAOK20.95461384
65BRSK20.95206434
66GRK60.94988765
67RIPK10.91732728
68ILK0.90969659
69FER0.90926459
70MAP3K30.89606305
71CLK10.88454314
72PIM10.86307525
73MAP3K80.86095828
74MAP3K50.85241832
75HCK0.82994271
76GRK50.82659820
77LIMK10.82633738
78PAK20.79368959
79ZAK0.78767316
80NEK20.78042423
81TXK0.78014501
82PAK10.77662358
83MAP3K100.77323117
84ERBB30.76751817
85PBK0.75474748
86LCK0.74236982
87PDGFRB0.71789651
88FGFR40.71642455
89TESK20.70185950
90EPHB20.69366595
91EIF2AK10.69056203
92DAPK30.68793270
93MST40.66829002
94RPS6KB20.66724600
95DDR20.66124834
96PLK20.65810885
97MARK30.64179946
98MAPK120.63490382
99PDK10.62973517
100IRAK30.62780584
101CDC70.62020682
102GRK70.60731982
103PDPK10.60105362
104LYN0.59615634
105ADRBK10.58830631
106RET0.55198616
107MAPKAPK20.55146700
108PRKG20.54346630
109FGFR20.52949940
110ABL20.52557216
111SYK0.50896040
112ACVR1B0.50091086
113IGF1R0.49773835
114CAMK1D0.48526195
115MKNK10.48232870
116STK240.48121687
117BMPR1B0.47944576
118YES10.47644422
119MATK0.47559795
120SIK10.46946831
121EGFR0.46919631
122JAK20.46704282
123MOS0.46270673
124NLK0.45824166
125PIK3CA0.45800014
126AURKB0.45493806
127PRKD10.45420883
128ABL10.44979769
129FGFR10.44781871
130SIK30.44464472
131PIK3CG0.43688929
132PRKCQ0.42796036
133PTK20.41366363
134MAP3K10.41085040
135MAP2K10.40021854
136PRKACG0.39548809
137MAP3K130.39006380
138CDC42BPA0.36642885
139ERBB20.35009657
140CAMK1G0.34134891
141FYN0.33962229
142PNCK0.33111913
143PRKCD0.31223162

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.52087436
2Viral myocarditis_Homo sapiens_hsa054162.17891977
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.05526409
4Malaria_Homo sapiens_hsa051441.99096948
5Legionellosis_Homo sapiens_hsa051341.96848979
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.93090161
7Leukocyte transendothelial migration_Homo sapiens_hsa046701.84483650
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.78719473
9Measles_Homo sapiens_hsa051621.77896230
10Small cell lung cancer_Homo sapiens_hsa052221.76864405
11Osteoclast differentiation_Homo sapiens_hsa043801.74893211
12Toxoplasmosis_Homo sapiens_hsa051451.73080442
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71418923
14ECM-receptor interaction_Homo sapiens_hsa045121.70094725
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.63539616
16Shigellosis_Homo sapiens_hsa051311.62375909
17Focal adhesion_Homo sapiens_hsa045101.60923371
18Hematopoietic cell lineage_Homo sapiens_hsa046401.60451898
19Antigen processing and presentation_Homo sapiens_hsa046121.57615244
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57010457
21Graft-versus-host disease_Homo sapiens_hsa053321.50874981
22Herpes simplex infection_Homo sapiens_hsa051681.48621769
23Pertussis_Homo sapiens_hsa051331.48558367
24TNF signaling pathway_Homo sapiens_hsa046681.47997757
25Adherens junction_Homo sapiens_hsa045201.44938584
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44792545
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44588132
28Salmonella infection_Homo sapiens_hsa051321.43789481
29Apoptosis_Homo sapiens_hsa042101.41781859
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39792838
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37886351
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34976942
33Chronic myeloid leukemia_Homo sapiens_hsa052201.34161947
34Tuberculosis_Homo sapiens_hsa051521.33587508
35Hepatitis B_Homo sapiens_hsa051611.32171544
36Proteoglycans in cancer_Homo sapiens_hsa052051.30296531
37Allograft rejection_Homo sapiens_hsa053301.30056987
38B cell receptor signaling pathway_Homo sapiens_hsa046621.29901383
39Influenza A_Homo sapiens_hsa051641.29275223
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28959363
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.28545153
42Amoebiasis_Homo sapiens_hsa051461.27357030
43p53 signaling pathway_Homo sapiens_hsa041151.26438422
44Platelet activation_Homo sapiens_hsa046111.26292735
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23861631
46DNA replication_Homo sapiens_hsa030301.23748476
47Pancreatic cancer_Homo sapiens_hsa052121.23300975
48MicroRNAs in cancer_Homo sapiens_hsa052061.18019107
49Viral carcinogenesis_Homo sapiens_hsa052031.17630242
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16806007
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.14968051
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.10851749
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10528207
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10103060
55Arachidonic acid metabolism_Homo sapiens_hsa005901.09952323
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09853118
57Cell cycle_Homo sapiens_hsa041101.09333357
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06976578
59Primary immunodeficiency_Homo sapiens_hsa053401.05138839
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04717226
61HTLV-I infection_Homo sapiens_hsa051661.04511516
62Phagosome_Homo sapiens_hsa041451.02733046
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01518058
64Staphylococcus aureus infection_Homo sapiens_hsa051501.01386199
65Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00848746
66Collecting duct acid secretion_Homo sapiens_hsa049661.00682941
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.97534091
68Gap junction_Homo sapiens_hsa045400.94857393
69Chemokine signaling pathway_Homo sapiens_hsa040620.93917612
70Lysosome_Homo sapiens_hsa041420.93718521
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92249774
72TGF-beta signaling pathway_Homo sapiens_hsa043500.90038034
73Dilated cardiomyopathy_Homo sapiens_hsa054140.89949154
74Epstein-Barr virus infection_Homo sapiens_hsa051690.87616697
75Nitrogen metabolism_Homo sapiens_hsa009100.85768088
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.85360232
77Asthma_Homo sapiens_hsa053100.85347592
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82952841
79Sulfur metabolism_Homo sapiens_hsa009200.82226175
80HIF-1 signaling pathway_Homo sapiens_hsa040660.81935395
81Systemic lupus erythematosus_Homo sapiens_hsa053220.80230043
82Acute myeloid leukemia_Homo sapiens_hsa052210.77446344
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77335304
84Pathways in cancer_Homo sapiens_hsa052000.76319361
85Prostate cancer_Homo sapiens_hsa052150.76277523
86Hepatitis C_Homo sapiens_hsa051600.75715848
87Rheumatoid arthritis_Homo sapiens_hsa053230.74369603
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74203271
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73411030
90Complement and coagulation cascades_Homo sapiens_hsa046100.73240249
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73000608
92T cell receptor signaling pathway_Homo sapiens_hsa046600.72217126
93Base excision repair_Homo sapiens_hsa034100.70214180
94Colorectal cancer_Homo sapiens_hsa052100.68011254
95Mismatch repair_Homo sapiens_hsa034300.67133150
96Other glycan degradation_Homo sapiens_hsa005110.65839984
97Serotonergic synapse_Homo sapiens_hsa047260.64738354
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.64632078
99African trypanosomiasis_Homo sapiens_hsa051430.62787364
100Notch signaling pathway_Homo sapiens_hsa043300.62128868
101Sphingolipid metabolism_Homo sapiens_hsa006000.60817076
102Pancreatic secretion_Homo sapiens_hsa049720.59452077
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59440516
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58926322
105Glycerolipid metabolism_Homo sapiens_hsa005610.57633605
106Bladder cancer_Homo sapiens_hsa052190.57105214
107Autoimmune thyroid disease_Homo sapiens_hsa053200.57095866
108Type I diabetes mellitus_Homo sapiens_hsa049400.56781648
109Renal cell carcinoma_Homo sapiens_hsa052110.55819362
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55636878
111Melanoma_Homo sapiens_hsa052180.53293329
112VEGF signaling pathway_Homo sapiens_hsa043700.53156645
113Ras signaling pathway_Homo sapiens_hsa040140.52755922
114FoxO signaling pathway_Homo sapiens_hsa040680.52747705
115Rap1 signaling pathway_Homo sapiens_hsa040150.52476877
116Thyroid cancer_Homo sapiens_hsa052160.50838972
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.50445421
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.50306222
119Proteasome_Homo sapiens_hsa030500.50175452
120Long-term depression_Homo sapiens_hsa047300.49483895
121Renin-angiotensin system_Homo sapiens_hsa046140.49287387
122Insulin resistance_Homo sapiens_hsa049310.47401987
123Endocytosis_Homo sapiens_hsa041440.46427358
124Ribosome_Homo sapiens_hsa030100.46339210
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46156806
126Choline metabolism in cancer_Homo sapiens_hsa052310.45945506
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44766407
128Nucleotide excision repair_Homo sapiens_hsa034200.43022529
129Non-small cell lung cancer_Homo sapiens_hsa052230.43005152

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