LIMS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.90119580
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.90119580
3L-phenylalanine metabolic process (GO:0006558)5.65406117
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.65406117
5aromatic amino acid family catabolic process (GO:0009074)4.98728581
6alpha-linolenic acid metabolic process (GO:0036109)4.81987645
7cardiac myofibril assembly (GO:0055003)4.73659748
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.61522552
9glyoxylate metabolic process (GO:0046487)4.61378233
10complement activation, alternative pathway (GO:0006957)4.57149080
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45939388
12lysine catabolic process (GO:0006554)4.44497199
13lysine metabolic process (GO:0006553)4.44497199
14kynurenine metabolic process (GO:0070189)4.43274321
15bile acid biosynthetic process (GO:0006699)4.40416501
16regulation of protein activation cascade (GO:2000257)4.34167089
17cell migration involved in heart development (GO:0060973)4.30757782
18negative regulation of fibrinolysis (GO:0051918)4.27618834
19indole-containing compound catabolic process (GO:0042436)4.25387608
20indolalkylamine catabolic process (GO:0046218)4.25387608
21tryptophan catabolic process (GO:0006569)4.25387608
22regulation of triglyceride catabolic process (GO:0010896)4.25336537
23homocysteine metabolic process (GO:0050667)4.20815234
24regulation of complement activation (GO:0030449)4.17905769
25sulfur amino acid catabolic process (GO:0000098)4.17525880
26myofibril assembly (GO:0030239)4.13154127
27peptidyl-glutamic acid carboxylation (GO:0017187)4.08443113
28protein carboxylation (GO:0018214)4.08443113
29fatty acid beta-oxidation (GO:0006635)4.04916184
30tryptophan metabolic process (GO:0006568)3.99841696
31regulation of fibrinolysis (GO:0051917)3.98515055
32fatty acid transmembrane transport (GO:1902001)3.96506091
33cysteine metabolic process (GO:0006534)3.96056153
34cellular ketone body metabolic process (GO:0046950)3.91021205
35acetyl-CoA metabolic process (GO:0006084)3.89525177
36extracellular matrix assembly (GO:0085029)3.88676743
37plasma lipoprotein particle clearance (GO:0034381)3.87257717
38high-density lipoprotein particle remodeling (GO:0034375)3.84588707
39acylglycerol homeostasis (GO:0055090)3.84426797
40triglyceride homeostasis (GO:0070328)3.84426797
41amino-acid betaine metabolic process (GO:0006577)3.82624723
42sarcomere organization (GO:0045214)3.82012175
43aspartate family amino acid catabolic process (GO:0009068)3.81472174
44atrioventricular valve morphogenesis (GO:0003181)3.79566581
45protein heterotrimerization (GO:0070208)3.79428987
46fatty acid oxidation (GO:0019395)3.78042463
47urea cycle (GO:0000050)3.77831885
48urea metabolic process (GO:0019627)3.77831885
49regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.77096779
50fatty acid catabolic process (GO:0009062)3.74516701
51bile acid metabolic process (GO:0008206)3.74047301
52short-chain fatty acid metabolic process (GO:0046459)3.71797300
53muscle filament sliding (GO:0030049)3.70942495
54actin-myosin filament sliding (GO:0033275)3.70942495
55lipid oxidation (GO:0034440)3.70195128
56regulation of sequestering of triglyceride (GO:0010889)3.67969083
572-oxoglutarate metabolic process (GO:0006103)3.66679030
58cardiac muscle contraction (GO:0060048)3.65924054
59alpha-amino acid catabolic process (GO:1901606)3.64784377
60serine family amino acid catabolic process (GO:0009071)3.62810144
61extracellular fibril organization (GO:0043206)3.58685504
62carnitine shuttle (GO:0006853)3.57177970
63ethanol oxidation (GO:0006069)3.56505339
64positive regulation of fatty acid beta-oxidation (GO:0032000)3.54226448
65aromatic amino acid family metabolic process (GO:0009072)3.53809073
66monocarboxylic acid catabolic process (GO:0072329)3.52903726
67coenzyme catabolic process (GO:0009109)3.52067071
68nitrogen cycle metabolic process (GO:0071941)3.49157024
69tyrosine metabolic process (GO:0006570)3.48417302
70regulation of the force of heart contraction (GO:0002026)3.47786891
71regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.46327112
72cellular response to epinephrine stimulus (GO:0071872)3.45586788
73cellular amino acid catabolic process (GO:0009063)3.43819535
74reverse cholesterol transport (GO:0043691)3.42994978
75stress fiber assembly (GO:0043149)3.39753721
76positive regulation of fatty acid oxidation (GO:0046321)3.37800808
77ketone body metabolic process (GO:1902224)3.35520724
78phospholipid homeostasis (GO:0055091)3.34515127
79plasma lipoprotein particle remodeling (GO:0034369)3.30826164
80protein-lipid complex remodeling (GO:0034368)3.30826164
81macromolecular complex remodeling (GO:0034367)3.30826164
82positive regulation of lipid catabolic process (GO:0050996)3.30479028
83barbed-end actin filament capping (GO:0051016)3.30277630
84carboxylic acid catabolic process (GO:0046395)3.28943529
85organic acid catabolic process (GO:0016054)3.28943529
86regulation of cholesterol esterification (GO:0010872)3.27638429
87branched-chain amino acid catabolic process (GO:0009083)3.27442969
88fibrinolysis (GO:0042730)3.26537187
89actin-mediated cell contraction (GO:0070252)3.24904225
90positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.23906788
91virion attachment to host cell (GO:0019062)3.22668089
92adhesion of symbiont to host cell (GO:0044650)3.22668089
93response to epinephrine (GO:0071871)3.22646276
94negative regulation of protein activation cascade (GO:2000258)3.22292143
95epoxygenase P450 pathway (GO:0019373)3.21241378
96low-density lipoprotein particle clearance (GO:0034383)3.20892311
97fibril organization (GO:0097435)3.20814831
98valine metabolic process (GO:0006573)3.20298713
99negative regulation of lipase activity (GO:0060192)3.18998747
100actomyosin structure organization (GO:0031032)3.18901339
101glutamate metabolic process (GO:0006536)3.18461075
102biotin metabolic process (GO:0006768)3.18448065
103regulation of actin filament-based movement (GO:1903115)3.17476169
104response to mercury ion (GO:0046689)3.17357215
105cellular modified amino acid catabolic process (GO:0042219)3.16258545
106positive regulation of lipoprotein lipase activity (GO:0051006)3.15360744
107positive regulation of triglyceride lipase activity (GO:0061365)3.15360744
108carnitine metabolic process (GO:0009437)3.14153364
109cardiac muscle hypertrophy (GO:0003300)3.13974231
110bile acid and bile salt transport (GO:0015721)3.12455636
111positive regulation of receptor recycling (GO:0001921)3.11160922
112cholesterol homeostasis (GO:0042632)3.10850551
113regulation of fatty acid oxidation (GO:0046320)3.10669730
114sterol homeostasis (GO:0055092)3.09180598
115cellular glucuronidation (GO:0052695)3.08316248
116dicarboxylic acid biosynthetic process (GO:0043650)3.07977444
117regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.07698207
118drug metabolic process (GO:0017144)3.06664615
119heme transport (GO:0015886)3.04718692
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.03841047
121benzene-containing compound metabolic process (GO:0042537)3.03100580
122regulation of cholesterol homeostasis (GO:2000188)3.03021314
123regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.02540724
124branched-chain amino acid metabolic process (GO:0009081)3.02538172
125cGMP-mediated signaling (GO:0019934)3.01391880
126negative regulation of sterol transport (GO:0032372)3.00955355
127negative regulation of cholesterol transport (GO:0032375)3.00955355
128phospholipid efflux (GO:0033700)3.00906446
129arginine metabolic process (GO:0006525)3.00871739
130drug catabolic process (GO:0042737)3.00558593
131vascular endothelial growth factor signaling pathway (GO:0038084)3.00451934
132regulation of plasminogen activation (GO:0010755)3.00004104
133striated muscle hypertrophy (GO:0014897)2.98797141
134cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98138592
135collagen fibril organization (GO:0030199)2.97133166
136endocardial cushion development (GO:0003197)2.96891282
137adhesion of symbiont to host (GO:0044406)2.96223057
138cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93856774
139venous blood vessel morphogenesis (GO:0048845)2.93560486
140peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.91288670
141dermatan sulfate metabolic process (GO:0030205)2.89511877
142basement membrane organization (GO:0071711)2.86227114
143regulation of cardioblast differentiation (GO:0051890)2.85215552
144muscle hypertrophy (GO:0014896)2.83369040
145retina vasculature morphogenesis in camera-type eye (GO:0061299)2.82866964
146cardiac muscle tissue morphogenesis (GO:0055008)2.81438216
147ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.79329786
148negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.74722168
149neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.73343484
150cardiac muscle cell development (GO:0055013)2.73127285
151regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.72203684
152cardiac cell development (GO:0055006)2.70976430
153muscle tissue morphogenesis (GO:0060415)2.68942619
154cardiac muscle adaptation (GO:0014887)2.68930691
155cardiac muscle hypertrophy in response to stress (GO:0014898)2.68930691
156muscle hypertrophy in response to stress (GO:0003299)2.68930691
157heart trabecula formation (GO:0060347)2.65303891
158chondroitin sulfate catabolic process (GO:0030207)2.64416042
159actin filament-based movement (GO:0030048)2.63322466
160dermatan sulfate biosynthetic process (GO:0030208)2.62776641
161striated muscle contraction (GO:0006941)2.62624439
162adherens junction assembly (GO:0034333)2.62154002
163endothelial cell morphogenesis (GO:0001886)2.61097997
164cAMP biosynthetic process (GO:0006171)2.58192760
165regulation of striated muscle contraction (GO:0006942)2.55748483
166cell communication by electrical coupling (GO:0010644)2.53491083
167focal adhesion assembly (GO:0048041)2.51931900
168cell-substrate adherens junction assembly (GO:0007045)2.51931900
169regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.49923636
170regulation of relaxation of muscle (GO:1901077)2.48743376
171cell-substrate junction assembly (GO:0007044)2.48490498
172endodermal cell differentiation (GO:0035987)2.47167721
173type B pancreatic cell proliferation (GO:0044342)2.46170276
174cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.45180513
175negative regulation of smooth muscle cell migration (GO:0014912)2.44480805
176negative regulation of protein localization to cell surface (GO:2000009)2.44411054
177epithelial cell-cell adhesion (GO:0090136)2.43268472
178NADH metabolic process (GO:0006734)2.40518265
179positive regulation of endothelial cell apoptotic process (GO:2000353)2.40429582
180cell volume homeostasis (GO:0006884)2.40042267
181fibroblast migration (GO:0010761)2.38060938
182regulation of cardiac muscle cell contraction (GO:0086004)2.37646893
183muscle contraction (GO:0006936)2.36746849
184cardiac muscle tissue development (GO:0048738)2.36215978
185triglyceride catabolic process (GO:0019433)2.35265888
186activation of protein kinase A activity (GO:0034199)2.35206583
187regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.35044419
188keratan sulfate catabolic process (GO:0042340)2.35041192
189actin filament depolymerization (GO:0030042)2.34996268
190response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.34627000
191glomerular filtration (GO:0003094)2.32307184
192vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32180149
193cardiac chamber formation (GO:0003207)2.31045052
194blood vessel maturation (GO:0001955)2.30854219
195regulation of cardiac muscle contraction (GO:0055117)2.30658958
196chondrocyte proliferation (GO:0035988)2.30475535
197glomerular basement membrane development (GO:0032836)2.29464900
198regulation of p38MAPK cascade (GO:1900744)2.29361672
199endothelium development (GO:0003158)2.28697355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.21187241
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.13547212
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.89300779
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.02431895
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.87140538
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09536993
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.05692126
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.32064427
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.92368932
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.85391189
11CLOCK_20551151_ChIP-Seq_293T_Human2.42847238
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.20454756
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05883205
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95366126
15ELK3_25401928_ChIP-Seq_HUVEC_Human1.85152494
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83556224
17EZH2_22144423_ChIP-Seq_EOC_Human1.72189137
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.71295721
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.69530838
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67737316
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67737316
22GATA1_22025678_ChIP-Seq_K562_Human1.67317779
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61881196
24DROSHA_22980978_ChIP-Seq_HELA_Human1.60130405
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.58562837
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57335709
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57307417
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.55676278
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55666574
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53541284
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50125728
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.46785238
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45900903
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.44952186
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.44952186
36* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44288092
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42714469
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.42612908
39KDM2B_26808549_Chip-Seq_K562_Human1.41673110
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41214675
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39934218
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.38684020
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34618145
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34598539
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33207988
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31275197
47SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29985613
48* EZH2_27294783_Chip-Seq_ESCs_Mouse1.26446570
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24254750
50KDM2B_26808549_Chip-Seq_DND41_Human1.24174023
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.22950136
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22636745
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21079032
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20903251
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20473802
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.20451045
57TP53_23651856_ChIP-Seq_MEFs_Mouse1.20129507
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18324461
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17767871
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17372286
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16928405
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16422508
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15398590
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.14517678
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13133407
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11830075
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11830075
68ZNF263_19887448_ChIP-Seq_K562_Human1.10668825
69* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10650424
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10215113
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07499652
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06321872
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05097597
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04939045
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.04016478
76SA1_22415368_ChIP-Seq_MEFs_Mouse1.02677453
77HNF4A_19822575_ChIP-Seq_HepG2_Human1.02266160
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01457163
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00908742
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00039358
81P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99305448
82SMC4_20622854_ChIP-Seq_HELA_Human0.98330707
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97095910
84TP53_20018659_ChIP-ChIP_R1E_Mouse0.96314619
85SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96049741
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95628751
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94264446
88TCF7_22412390_ChIP-Seq_EML_Mouse0.94154820
89TET1_21490601_ChIP-Seq_MESCs_Mouse0.92835694
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.92097765
91JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90294405
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89513482
93ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89494078
94GATA1_19941826_ChIP-Seq_K562_Human0.88298582
95HTT_18923047_ChIP-ChIP_STHdh_Human0.87032142
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86921360
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.86755074
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86216363
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85411047
100CJUN_26792858_Chip-Seq_BT549_Human0.84468347
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84282353
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81236031
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80910142
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76866477
105* LXR_22292898_ChIP-Seq_THP-1_Human0.75356700
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75334596
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73885576
108* SOX2_20726797_ChIP-Seq_SW620_Human0.72009722
109* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70547101
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68902912
111SOX9_24532713_ChIP-Seq_HFSC_Mouse0.68622391
112GATA4_25053715_ChIP-Seq_YYC3_Human0.68287263
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67908297
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.67462991
115GATA2_19941826_ChIP-Seq_K562_Human0.67350539
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66557798
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.66295313
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.66127768
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.65679528
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.65627325
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.64841070
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64651673
123BCAT_22108803_ChIP-Seq_LS180_Human0.64507166
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.62927159
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62794918
126CSB_26484114_Chip-Seq_FIBROBLAST_Human0.62477411
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61168864
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61089976
129AR_21572438_ChIP-Seq_LNCaP_Human0.60626813
130CTCF_27219007_Chip-Seq_Bcells_Human0.60216964
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59866589
132EGR1_19032775_ChIP-ChIP_M12_Human0.59543638
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.59289699
134RACK7_27058665_Chip-Seq_MCF-7_Human0.58091398
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.57418827
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.57303172
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56591484
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.56425676
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.56111354
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.55990059
141AHR_22903824_ChIP-Seq_MCF-7_Human0.55981023
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55571626
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55378192
144CBP_21632823_ChIP-Seq_H3396_Human0.55101451
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.55095884
146CEBPB_22108803_ChIP-Seq_LS180_Human0.54916172
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54879245
148RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.54357299
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.53444501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.80988339
2MP0005360_urolithiasis5.58556103
3MP0005085_abnormal_gallbladder_physiolo4.49299832
4MP0005365_abnormal_bile_salt4.38334876
5MP0008875_abnormal_xenobiotic_pharmacok3.79735083
6MP0005503_abnormal_tendon_morphology3.43814639
7MP0002837_dystrophic_cardiac_calcinosis3.38810023
8MP0003806_abnormal_nucleotide_metabolis3.22621651
9MP0010329_abnormal_lipoprotein_level2.85116286
10MP0003252_abnormal_bile_duct2.80761593
11MP0005670_abnormal_white_adipose2.52365954
12MP0009840_abnormal_foam_cell2.47809103
13MP0005332_abnormal_amino_acid2.38864382
14MP0010368_abnormal_lymphatic_system2.36155581
15MP0004130_abnormal_muscle_cell2.18532806
16MP0003191_abnormal_cellular_cholesterol2.16663158
17MP0004084_abnormal_cardiac_muscle2.09264879
18MP0003195_calcinosis2.06198261
19MP0004510_myositis2.05961926
20MP0003646_muscle_fatigue2.00734184
21MP0005083_abnormal_biliary_tract1.98927536
22MP0002118_abnormal_lipid_homeostasis1.98306991
23MP0008438_abnormal_cutaneous_collagen1.95609542
24MP0000751_myopathy1.88517674
25MP0003566_abnormal_cell_adhesion1.86347205
26MP0004036_abnormal_muscle_relaxation1.85285785
27MP0005330_cardiomyopathy1.81546592
28MP0001666_abnormal_nutrient_absorption1.76896069
29MP0005666_abnormal_adipose_tissue1.76713648
30MP0005257_abnormal_intraocular_pressure1.71210429
31MP0002108_abnormal_muscle_morphology1.68239889
32MP0000609_abnormal_liver_physiology1.64085690
33MP0005319_abnormal_enzyme/_coenzyme1.60693280
34MP0004215_abnormal_myocardial_fiber1.57319922
35MP0003091_abnormal_cell_migration1.57162820
36MP0000749_muscle_degeneration1.54091056
37MP0001542_abnormal_bone_strength1.54040903
38MP0002138_abnormal_hepatobiliary_system1.51867842
39MP0003705_abnormal_hypodermis_morpholog1.42755441
40MP0005171_absent_coat_pigmentation1.41588402
41MP0005584_abnormal_enzyme/coenzyme_acti1.40130458
42MP0004019_abnormal_vitamin_homeostasis1.39402820
43MP0002933_joint_inflammation1.37677354
44MP0004185_abnormal_adipocyte_glucose1.37122676
45MP0006138_congestive_heart_failure1.35555166
46MP0008775_abnormal_heart_ventricle1.32687759
47MP0005409_darkened_coat_color1.30798050
48MP0009780_abnormal_chondrocyte_physiolo1.30523880
49MP0005167_abnormal_blood-brain_barrier1.28340797
50MP0009643_abnormal_urine_homeostasis1.27749316
51MP0005508_abnormal_skeleton_morphology1.26297870
52MP0005023_abnormal_wound_healing1.24887121
53MP0005375_adipose_tissue_phenotype1.23466388
54MP0005369_muscle_phenotype1.22841947
55MP0004272_abnormal_basement_membrane1.22771090
56MP0004087_abnormal_muscle_fiber1.22114811
57MP0003690_abnormal_glial_cell1.21993561
58MP0001879_abnormal_lymphatic_vessel1.20894655
59MP0005451_abnormal_body_composition1.19956750
60MP0005385_cardiovascular_system_phenoty1.19223761
61MP0001544_abnormal_cardiovascular_syste1.19223761
62MP0001661_extended_life_span1.18655566
63MP0003283_abnormal_digestive_organ1.18577993
64MP0002127_abnormal_cardiovascular_syste1.17781153
65* MP0002972_abnormal_cardiac_muscle1.17459975
66MP0005623_abnormal_meninges_morphology1.16636429
67MP0006036_abnormal_mitochondrial_physio1.15716583
68MP0003868_abnormal_feces_composition1.12611701
69* MP0005620_abnormal_muscle_contractility1.11476864
70MP0003950_abnormal_plasma_membrane1.11414933
71MP0002971_abnormal_brown_adipose1.09493902
72MP0002269_muscular_atrophy1.02775047
73MP0005058_abnormal_lysosome_morphology1.02292719
74MP0005275_abnormal_skin_tensile0.98783128
75MP0000230_abnormal_systemic_arterial0.97815775
76MP0002896_abnormal_bone_mineralization0.97773940
77MP0002295_abnormal_pulmonary_circulatio0.97642802
78MP0004145_abnormal_muscle_electrophysio0.97301234
79MP0003186_abnormal_redox_activity0.97201346
80MP0010630_abnormal_cardiac_muscle0.96146901
81MP0000747_muscle_weakness0.95253376
82MP0003724_increased_susceptibility_to0.94712885
83MP0001764_abnormal_homeostasis0.93943606
84MP0006054_spinal_hemorrhage0.93113687
85MP0000750_abnormal_muscle_regeneration0.90562611
86MP0009697_abnormal_copulation0.89879449
87MP0003045_fibrosis0.89793792
88MP0002060_abnormal_skin_morphology0.87433102
89MP0000733_abnormal_muscle_development0.87329133
90MP0000013_abnormal_adipose_tissue0.86351495
91MP0005165_increased_susceptibility_to0.85894027
92MP0001756_abnormal_urination0.85232310
93MP0003011_delayed_dark_adaptation0.84553220
94MP0005390_skeleton_phenotype0.84310124
95MP0004085_abnormal_heartbeat0.83778007
96MP0003656_abnormal_erythrocyte_physiolo0.83251942
97MP0002254_reproductive_system_inflammat0.83161390
98MP0000604_amyloidosis0.82230323
99MP0003137_abnormal_impulse_conducting0.81939334
100MP0005334_abnormal_fat_pad0.81252938
101MP0003279_aneurysm0.80369581
102MP0000003_abnormal_adipose_tissue0.79702993
103MP0000249_abnormal_blood_vessel0.79492953
104MP0000920_abnormal_myelination0.78020592
105MP0004484_altered_response_of0.77815582
106MP0005388_respiratory_system_phenotype0.77298784
107MP0002133_abnormal_respiratory_system0.77298784
108MP0000598_abnormal_liver_morphology0.77286241
109MP0002877_abnormal_melanocyte_morpholog0.77272566
110MP0009384_cardiac_valve_regurgitation0.77011638
111MP0005595_abnormal_vascular_smooth0.76891319
112MP0004858_abnormal_nervous_system0.76738158
113MP0009763_increased_sensitivity_to0.75605967
114MP0003329_amyloid_beta_deposits0.75409036
115MP0002078_abnormal_glucose_homeostasis0.75362435
116MP0002998_abnormal_bone_remodeling0.75261646
117MP0005647_abnormal_sex_gland0.74691003
118MP0005535_abnormal_body_temperature0.74180593
119MP0003828_pulmonary_edema0.73437776
120MP0001614_abnormal_blood_vessel0.72919536
121MP0009115_abnormal_fat_cell0.72783081
122MP0001958_emphysema0.72773866
123MP0003075_altered_response_to0.72723081
124MP0003221_abnormal_cardiomyocyte_apopto0.70768598
125MP0005376_homeostasis/metabolism_phenot0.68939198
126* MP0000343_altered_response_to0.67840614
127MP0000266_abnormal_heart_morphology0.67221376
128MP0002106_abnormal_muscle_physiology0.67174640
129MP0009764_decreased_sensitivity_to0.66307037
130MP0009642_abnormal_blood_homeostasis0.65860532
131MP0001299_abnormal_eye_distance/0.65821933
132MP0004233_abnormal_muscle_weight0.65412553
133MP0002332_abnormal_exercise_endurance0.64800733
134MP0000759_abnormal_skeletal_muscle0.64736660
135MP0005164_abnormal_response_to0.63779745
136MP0002128_abnormal_blood_circulation0.63616683
137MP0000767_abnormal_smooth_muscle0.63267694
138MP0001533_abnormal_skeleton_physiology0.62893042
139MP0004883_abnormal_blood_vessel0.61386695
140MP0000462_abnormal_digestive_system0.61069294
141MP0000163_abnormal_cartilage_morphology0.59996106
142MP0001348_abnormal_lacrimal_gland0.57697997

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.55655381
2Protrusio acetabuli (HP:0003179)5.52887778
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.10645542
4Intrahepatic cholestasis (HP:0001406)5.08449139
5Aortic aneurysm (HP:0004942)5.07022108
6Premature rupture of membranes (HP:0001788)4.85501937
7Xanthomatosis (HP:0000991)4.83804624
8Type 1 muscle fiber predominance (HP:0003803)4.57128580
9Complement deficiency (HP:0004431)4.54092597
10Hyperlipoproteinemia (HP:0010980)4.50085139
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.23540680
12Prolonged partial thromboplastin time (HP:0003645)4.09465239
13Hyperammonemia (HP:0001987)4.04243029
14Aortic dissection (HP:0002647)4.03979641
15Ketosis (HP:0001946)4.02644684
16Hyperglycinuria (HP:0003108)3.85341872
17Hypobetalipoproteinemia (HP:0003563)3.76863079
18Hypoglycemic coma (HP:0001325)3.76303113
19Increased variability in muscle fiber diameter (HP:0003557)3.75534978
20Abnormality of serine family amino acid metabolism (HP:0010894)3.73871385
21Abnormality of glycine metabolism (HP:0010895)3.73871385
22Hypoalphalipoproteinemia (HP:0003233)3.70767729
23Abnormality of fatty-acid metabolism (HP:0004359)3.67208332
24Bundle branch block (HP:0011710)3.59567895
25Distal lower limb muscle weakness (HP:0009053)3.51822844
26Hypolipoproteinemia (HP:0010981)3.48863993
27Hyperglycinemia (HP:0002154)3.42660683
28Cerebral aneurysm (HP:0004944)3.39222255
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.34654798
30Ketoacidosis (HP:0001993)3.32817159
31Muscle fiber splitting (HP:0003555)3.29133632
32Abnormality of skeletal muscle fiber size (HP:0012084)3.28525890
33Epidermoid cyst (HP:0200040)3.25279597
34Spinal rigidity (HP:0003306)3.24234472
35Vascular tortuosity (HP:0004948)3.23959676
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.19960171
37Sudden death (HP:0001699)3.14386231
38Abnormality of glutamine family amino acid metabolism (HP:0010902)3.13932548
39Abnormality of complement system (HP:0005339)3.13345352
40Hyporeflexia of lower limbs (HP:0002600)3.09693592
41Joint hemorrhage (HP:0005261)3.05805782
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.01357377
43Right ventricular cardiomyopathy (HP:0011663)2.98750645
44Abnormality of the common coagulation pathway (HP:0010990)2.98253986
45Myoglobinuria (HP:0002913)2.97395378
46Dicarboxylic aciduria (HP:0003215)2.96151515
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96151515
48Mildly elevated creatine phosphokinase (HP:0008180)2.92582010
49Supraventricular tachycardia (HP:0004755)2.92168187
50Abnormality of methionine metabolism (HP:0010901)2.89724320
51Aneurysm (HP:0002617)2.86723890
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.81771609
53Round ear (HP:0100830)2.79848163
54Soft skin (HP:0000977)2.79163168
55Ankle contracture (HP:0006466)2.78999310
56Abnormal atrioventricular conduction (HP:0005150)2.77989890
57Ventricular tachycardia (HP:0004756)2.76522573
58Aortic regurgitation (HP:0001659)2.75816065
59Dilatation of the ascending aorta (HP:0005111)2.72546660
60Exercise-induced myalgia (HP:0003738)2.71043301
61Abnormality of the left ventricular outflow tract (HP:0011103)2.69091738
62Subaortic stenosis (HP:0001682)2.69091738
63Bladder diverticulum (HP:0000015)2.68685029
64Arterial tortuosity (HP:0005116)2.68544321
65Shallow orbits (HP:0000586)2.67236782
66Abnormality of the intrinsic pathway (HP:0010989)2.65426884
67Hypercholesterolemia (HP:0003124)2.64838164
68Wormian bones (HP:0002645)2.64833688
69Fat malabsorption (HP:0002630)2.64565261
70Skin nodule (HP:0200036)2.64564081
71Heart block (HP:0012722)2.62511223
72Neck muscle weakness (HP:0000467)2.61565512
73Delayed CNS myelination (HP:0002188)2.57915641
74Systemic lupus erythematosus (HP:0002725)2.57333067
75Cervical subluxation (HP:0003308)2.54872822
76Mitral regurgitation (HP:0001653)2.53284367
77Cerebral edema (HP:0002181)2.51927894
78Mitral valve prolapse (HP:0001634)2.46540016
79Metabolic acidosis (HP:0001942)2.46536322
80Obstructive sleep apnea (HP:0002870)2.46454502
81Lethargy (HP:0001254)2.45320565
82Fragile skin (HP:0001030)2.45019660
83Calf muscle hypertrophy (HP:0008981)2.44925417
84Distal lower limb amyotrophy (HP:0008944)2.43953620
85Myocardial infarction (HP:0001658)2.41882081
86Hypoplasia of the iris (HP:0007676)2.39924566
87Polycythemia (HP:0001901)2.38437864
88Lipoatrophy (HP:0100578)2.38400107
89Ventricular arrhythmia (HP:0004308)2.38329719
90Lymphangioma (HP:0100764)2.37839077
91Esophageal varix (HP:0002040)2.37676719
92Cholelithiasis (HP:0001081)2.37528824
93Abnormal gallbladder morphology (HP:0012437)2.37522979
94Atrophic scars (HP:0001075)2.37147966
95Abnormality of purine metabolism (HP:0004352)2.35231304
96Amyloidosis (HP:0011034)2.33350682
97Wrist flexion contracture (HP:0001239)2.32093765
98Abnormality of serum amino acid levels (HP:0003112)2.31874809
99Pulmonary artery stenosis (HP:0004415)2.31111634
100Increased connective tissue (HP:0009025)2.30111532
101Cerebral hemorrhage (HP:0001342)2.30108007
102Exercise-induced muscle cramps (HP:0003710)2.29501995
103Syncope (HP:0001279)2.29003956
104Vascular calcification (HP:0004934)2.26719217
105Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.26668533
106Gout (HP:0001997)2.25462344
107Rhabdomyolysis (HP:0003201)2.24107657
108Blue sclerae (HP:0000592)2.22090259
109Muscle hypertrophy of the lower extremities (HP:0008968)2.21774712
110Joint stiffness (HP:0001387)2.20652593
111Nemaline bodies (HP:0003798)2.20260732
112Vomiting (HP:0002013)2.19023259
113Hyperbilirubinemia (HP:0002904)2.18312015
114Cardiovascular calcification (HP:0011915)2.17852444
115Ectopia lentis (HP:0001083)2.16416186
116Atrial fibrillation (HP:0005110)2.13772304
117Generalized aminoaciduria (HP:0002909)2.13438482
118Muscle fiber inclusion bodies (HP:0100299)2.11887597
119Centrally nucleated skeletal muscle fibers (HP:0003687)2.11362980
120Broad metatarsal (HP:0001783)2.10005453
121Aortic valve stenosis (HP:0001650)2.09759900
122Overgrowth (HP:0001548)2.09747027
123Atrioventricular block (HP:0001678)2.09617579
124Hepatocellular carcinoma (HP:0001402)2.09253112
125Hip contracture (HP:0003273)2.08878468
126Palpitations (HP:0001962)2.07374660
127Abnormality of nucleobase metabolism (HP:0010932)2.06951937
128Abnormal cartilage morphology (HP:0002763)2.06512631
129Abnormal gallbladder physiology (HP:0012438)2.05798892
130Cholecystitis (HP:0001082)2.05798892
131Biconcave vertebral bodies (HP:0004586)2.05292102
132Slender build (HP:0001533)2.04914945
133Prolonged QT interval (HP:0001657)2.04538870
134Dilated cardiomyopathy (HP:0001644)2.04069830
135Scapular winging (HP:0003691)2.03281886
136Abnormality of dentin (HP:0010299)2.02989877
137Vertebral compression fractures (HP:0002953)2.02072402
138Bradycardia (HP:0001662)2.01306292
139Hyperinsulinemic hypoglycemia (HP:0000825)2.01117441
140Peritonitis (HP:0002586)2.00257491
141Steatorrhea (HP:0002570)2.00058238
142Neonatal short-limb short stature (HP:0008921)1.99384573
143Difficulty running (HP:0009046)1.97756402
144Hydroxyprolinuria (HP:0003080)1.97397458
145Abnormality of proline metabolism (HP:0010907)1.97397458
146Spondylolisthesis (HP:0003302)1.97366430
147Glomerulonephritis (HP:0000099)1.97034630
148Hemorrhage of the eye (HP:0011885)1.96954371
149Abnormality of the calf musculature (HP:0001430)1.96293917
150Conjugated hyperbilirubinemia (HP:0002908)1.95112694
151Asymmetric septal hypertrophy (HP:0001670)1.94955078
152Malnutrition (HP:0004395)1.93819966
153Joint laxity (HP:0001388)1.92869350
154Lower limb amyotrophy (HP:0007210)1.91898459
155Spontaneous abortion (HP:0005268)1.91647247
156Follicular hyperkeratosis (HP:0007502)1.91071051
157Mitral stenosis (HP:0001718)1.90771712
158Primary atrial arrhythmia (HP:0001692)1.90157138
159Sensorimotor neuropathy (HP:0007141)1.89609884
160Stridor (HP:0010307)1.89583926
161EMG: myopathic abnormalities (HP:0003458)1.89409017
162Ulnar bowing (HP:0003031)1.88440487
163Increased muscle lipid content (HP:0009058)1.86955178
164Venous abnormality (HP:0002624)1.86240754
165Axonal loss (HP:0003447)1.85338857
166Abnormality of the gallbladder (HP:0005264)1.84968294
167EMG: neuropathic changes (HP:0003445)1.84877146
168Hypertriglyceridemia (HP:0002155)1.84389883
169Infantile muscular hypotonia (HP:0008947)1.83839342
170Emphysema (HP:0002097)1.83417286
171Myotonia (HP:0002486)1.82328984
172Wide anterior fontanel (HP:0000260)1.80722382
173Limited hip movement (HP:0008800)1.80639489
174Supraventricular arrhythmia (HP:0005115)1.80119472
175Abnormality of the foot musculature (HP:0001436)1.79642122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.79641019
2TIE13.83606427
3TTN3.29547988
4MYLK3.07815726
5PDK22.52615619
6TRIB32.51327396
7SIK12.50247101
8ERN12.39741016
9FGFR42.16865823
10PDK42.14733216
11PDK32.14733216
12PHKG12.03737319
13PHKG22.03737319
14TESK12.02862017
15EPHB12.00076197
16KDR1.99455073
17PIK3CA1.88200940
18CDC42BPA1.84288031
19LMTK21.78780308
20INSRR1.74134669
21STK391.73051664
22TGFBR21.71650532
23OBSCN1.71006990
24WNK41.66696842
25PRPF4B1.64753085
26MAP3K61.59674407
27LIMK11.50562931
28TYRO31.46475099
29FGFR21.45966426
30RIPK11.43831778
31PINK11.43489660
32PKN21.36756890
33PKN11.34592078
34DMPK1.33055704
35MAPK121.30958450
36PRKAA21.22536088
37CAMK1D1.19216801
38MAP3K31.17755087
39MARK21.16535207
40MST1R1.06564966
41ERBB41.06448655
42MET1.06284693
43PAK31.05058635
44CAMK11.04984400
45PRKD11.04640209
46EPHB21.02150873
47PTK2B1.00874060
48LATS11.00762596
49MAPKAPK30.99266535
50PTK60.97150381
51MAP3K70.95747862
52PDPK10.92225782
53PDGFRA0.92052876
54CSK0.92041213
55STK380.88359138
56CAMK1G0.88144820
57RPS6KA20.88010059
58PIK3CG0.87713529
59LATS20.86732029
60OXSR10.82551054
61MARK10.82342467
62MAP2K30.82252805
63TAOK20.79919534
64ABL20.79568983
65GSK3A0.79387780
66RPS6KL10.77887581
67RPS6KC10.77887581
68NTRK10.75940484
69STK38L0.75580742
70ICK0.74214002
71PRKAA10.74088097
72ROCK10.71548559
73TAOK10.71338558
74CAMK2D0.70973915
75CAMK2G0.70649559
76MAPK70.70405953
77MAP2K40.68447932
78KIT0.67278762
79PRKCH0.66728550
80TNK20.66689535
81NEK90.63392830
82RPS6KA60.62280843
83ZAP700.61888094
84FER0.61276073
85MAPK110.59416169
86JAK10.58799779
87PAK40.58573577
88DAPK30.56749729
89SGK2230.56590696
90SGK4940.56590696
91PAK20.56231638
92GRK50.55994196
93PRKACG0.55448369
94BMX0.55002552
95DAPK20.54698712
96DDR20.53454799
97EEF2K0.52385307
98MOS0.52214086
99MAPK40.51653098
100PDGFRB0.51372295
101CAMK2B0.50815239
102PDK10.50525721
103MAPK150.50111503
104AKT30.49047723
105MAP3K110.48008960
106PRKG20.47165569
107TBK10.46314279
108GRK70.46121777
109TYK20.45671458
110ADRBK10.44026956
111MAP2K10.43860751
112HIPK20.43686926
113WNK10.42719449
114ILK0.42428923
115JAK20.42266212
116CAMK40.42142176
117PTK20.40624970
118PRKACB0.40086237
119PRKD30.39696278
120TAOK30.37677627
121PAK60.37654173
122NTRK30.36035694
123ROCK20.35499520
124TRPM70.35471801
125SGK30.34795332
126EPHA30.34523490
127MTOR0.34183288
128MAP2K20.33733051
129MUSK0.33240481
130PRKCZ0.32747031
131CAMK2A0.32433999
132PRKD20.32378659
133PRKACA0.31921292

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58603430
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20513725
3Nitrogen metabolism_Homo sapiens_hsa009102.97379206
4Fatty acid degradation_Homo sapiens_hsa000712.90154603
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.87751716
6Propanoate metabolism_Homo sapiens_hsa006402.82100862
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68617598
8Arginine biosynthesis_Homo sapiens_hsa002202.66113434
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56201875
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51784131
11Tryptophan metabolism_Homo sapiens_hsa003802.49542709
12Fatty acid metabolism_Homo sapiens_hsa012122.34803141
13Complement and coagulation cascades_Homo sapiens_hsa046102.30413414
14PPAR signaling pathway_Homo sapiens_hsa033202.30275517
15Butanoate metabolism_Homo sapiens_hsa006502.28048404
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24506913
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15133693
18Peroxisome_Homo sapiens_hsa041461.96261273
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95263493
20Fatty acid elongation_Homo sapiens_hsa000621.94874559
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82544896
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78046612
23beta-Alanine metabolism_Homo sapiens_hsa004101.74120227
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.73913339
25Pyruvate metabolism_Homo sapiens_hsa006201.70883517
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68278488
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67897497
28Caffeine metabolism_Homo sapiens_hsa002321.64863187
29Histidine metabolism_Homo sapiens_hsa003401.56972737
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56812089
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55872994
32Chemical carcinogenesis_Homo sapiens_hsa052041.55501547
33Carbon metabolism_Homo sapiens_hsa012001.48819914
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.47413564
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.45633701
36Phenylalanine metabolism_Homo sapiens_hsa003601.44987268
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42263639
38Staphylococcus aureus infection_Homo sapiens_hsa051501.38437199
39Bile secretion_Homo sapiens_hsa049761.38000858
40Sulfur metabolism_Homo sapiens_hsa009201.33106130
41Other glycan degradation_Homo sapiens_hsa005111.31653696
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29238751
43Retinol metabolism_Homo sapiens_hsa008301.25701533
44Renin secretion_Homo sapiens_hsa049241.25662228
45Tyrosine metabolism_Homo sapiens_hsa003501.24343401
46Starch and sucrose metabolism_Homo sapiens_hsa005001.19922071
47Fat digestion and absorption_Homo sapiens_hsa049751.17151895
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14641301
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14107700
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.13901811
51Biosynthesis of amino acids_Homo sapiens_hsa012301.08848374
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08677539
53Arginine and proline metabolism_Homo sapiens_hsa003301.06974698
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06649730
55Notch signaling pathway_Homo sapiens_hsa043301.02919812
56Selenocompound metabolism_Homo sapiens_hsa004501.02856881
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01163297
58Malaria_Homo sapiens_hsa051441.00798966
59cAMP signaling pathway_Homo sapiens_hsa040240.99683741
60Adherens junction_Homo sapiens_hsa045200.99265379
61Steroid biosynthesis_Homo sapiens_hsa001000.99180220
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.99081907
63ABC transporters_Homo sapiens_hsa020100.98498479
64Proteoglycans in cancer_Homo sapiens_hsa052050.97467468
65Oxytocin signaling pathway_Homo sapiens_hsa049210.96408622
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92464569
67Fatty acid biosynthesis_Homo sapiens_hsa000610.90979479
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.90667819
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.87910696
70Melanogenesis_Homo sapiens_hsa049160.86445939
71Vitamin B6 metabolism_Homo sapiens_hsa007500.85586741
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85392972
73Glycerolipid metabolism_Homo sapiens_hsa005610.83765724
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83611431
75GnRH signaling pathway_Homo sapiens_hsa049120.81913115
76Calcium signaling pathway_Homo sapiens_hsa040200.80809663
77Lysine degradation_Homo sapiens_hsa003100.80343132
78Platelet activation_Homo sapiens_hsa046110.79764507
79Gastric acid secretion_Homo sapiens_hsa049710.78829907
80Vitamin digestion and absorption_Homo sapiens_hsa049770.78067399
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77410043
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77107704
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76358402
84Folate biosynthesis_Homo sapiens_hsa007900.74067596
85Pertussis_Homo sapiens_hsa051330.73854720
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73686777
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71913181
88Gap junction_Homo sapiens_hsa045400.71646965
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69998715
90Viral myocarditis_Homo sapiens_hsa054160.69697769
91Insulin secretion_Homo sapiens_hsa049110.69283715
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.64721936
93Circadian entrainment_Homo sapiens_hsa047130.63491073
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63263848
95Rap1 signaling pathway_Homo sapiens_hsa040150.63235093
96Glutathione metabolism_Homo sapiens_hsa004800.63161822
97Small cell lung cancer_Homo sapiens_hsa052220.61571132
98Estrogen signaling pathway_Homo sapiens_hsa049150.61065393
99Circadian rhythm_Homo sapiens_hsa047100.60232841
100Cocaine addiction_Homo sapiens_hsa050300.60089957
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59252170
102Dorso-ventral axis formation_Homo sapiens_hsa043200.58847022
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58013050
104VEGF signaling pathway_Homo sapiens_hsa043700.56299561
105Dilated cardiomyopathy_Homo sapiens_hsa054140.54061157
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53758495
107Insulin resistance_Homo sapiens_hsa049310.53634972
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.51886633
109Cholinergic synapse_Homo sapiens_hsa047250.51530546
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50160832
111Axon guidance_Homo sapiens_hsa043600.49465016
112Sulfur relay system_Homo sapiens_hsa041220.48902921
113Cardiac muscle contraction_Homo sapiens_hsa042600.48054037
114MAPK signaling pathway_Homo sapiens_hsa040100.47831885
115Long-term potentiation_Homo sapiens_hsa047200.47098257
116Pathways in cancer_Homo sapiens_hsa052000.45674056
117Glioma_Homo sapiens_hsa052140.45578988
118Prion diseases_Homo sapiens_hsa050200.45318068
119Metabolic pathways_Homo sapiens_hsa011000.44459858
120Salivary secretion_Homo sapiens_hsa049700.43271167
121Pentose phosphate pathway_Homo sapiens_hsa000300.42991736
122Endocytosis_Homo sapiens_hsa041440.42733302
123Pancreatic secretion_Homo sapiens_hsa049720.42675053
124Ras signaling pathway_Homo sapiens_hsa040140.41833400
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41739091
126Chronic myeloid leukemia_Homo sapiens_hsa052200.40655692
127Morphine addiction_Homo sapiens_hsa050320.40416600
128Osteoclast differentiation_Homo sapiens_hsa043800.40149414
129TGF-beta signaling pathway_Homo sapiens_hsa043500.39513495
130Toxoplasmosis_Homo sapiens_hsa051450.39243852
131TNF signaling pathway_Homo sapiens_hsa046680.38426952
132Lysosome_Homo sapiens_hsa041420.38422915
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.38104046
134Choline metabolism in cancer_Homo sapiens_hsa052310.38064685
135Renal cell carcinoma_Homo sapiens_hsa052110.37720543
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.37120004
137AMPK signaling pathway_Homo sapiens_hsa041520.37030585
138Oxidative phosphorylation_Homo sapiens_hsa001900.36664574
139ECM-receptor interaction_Homo sapiens_hsa045120.36033882
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34987232
141Linoleic acid metabolism_Homo sapiens_hsa005910.33572181
142Parkinsons disease_Homo sapiens_hsa050120.30169233
143Glucagon signaling pathway_Homo sapiens_hsa049220.30048247
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24871982
145Alzheimers disease_Homo sapiens_hsa050100.23075116
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.22845023
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20852353
148Fructose and mannose metabolism_Homo sapiens_hsa000510.19769860
149Ovarian steroidogenesis_Homo sapiens_hsa049130.19377729
150Focal adhesion_Homo sapiens_hsa045100.14526512
151Galactose metabolism_Homo sapiens_hsa000520.10902966
152Insulin signaling pathway_Homo sapiens_hsa049100.10812997
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.09501403
154Amoebiasis_Homo sapiens_hsa051460.08587067
155Protein digestion and absorption_Homo sapiens_hsa049740.08382076
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04673913
157Arachidonic acid metabolism_Homo sapiens_hsa005900.03398072
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0537305
159Tight junction_Homo sapiens_hsa04530-0.0530260
160Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0357040
161Ether lipid metabolism_Homo sapiens_hsa00565-0.0103402

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