LIMS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.93222060
2thrombin receptor signaling pathway (GO:0070493)6.76578404
3regulation of integrin-mediated signaling pathway (GO:2001044)5.29022146
4neutrophil activation involved in immune response (GO:0002283)4.74183062
5regulation of platelet activation (GO:0010543)4.65234340
6negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.38970282
7negative regulation of heart rate (GO:0010459)4.32200434
8purinergic nucleotide receptor signaling pathway (GO:0035590)4.29578704
9regulation of platelet aggregation (GO:0090330)4.27716440
10negative regulation of protein localization to cell surface (GO:2000009)4.26410728
11platelet dense granule organization (GO:0060155)4.26360928
12negative regulation of thymocyte apoptotic process (GO:0070244)4.16221878
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15857182
14blood coagulation, intrinsic pathway (GO:0007597)4.08131670
15endothelium development (GO:0003158)4.02401333
16negative regulation of platelet activation (GO:0010544)3.96722677
17angiogenesis involved in wound healing (GO:0060055)3.90566016
18positive regulation of cAMP-mediated signaling (GO:0043950)3.78067290
19leukocyte migration involved in inflammatory response (GO:0002523)3.76461748
20negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.70494158
21negative regulation of T-helper cell differentiation (GO:0045623)3.70494158
22positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.66206441
23positive regulation of endothelial cell differentiation (GO:0045603)3.59633342
24negative regulation of response to food (GO:0032096)3.58375985
25negative regulation of appetite (GO:0032099)3.58375985
26platelet aggregation (GO:0070527)3.56755989
27negative regulation of norepinephrine secretion (GO:0010700)3.53407390
28amine catabolic process (GO:0009310)3.49260220
29cellular biogenic amine catabolic process (GO:0042402)3.49260220
30low-density lipoprotein particle remodeling (GO:0034374)3.43058451
31regulation of lipoprotein metabolic process (GO:0050746)3.38406155
32fusion of sperm to egg plasma membrane (GO:0007342)3.37168269
33phospholipid homeostasis (GO:0055091)3.33497694
34adenosine receptor signaling pathway (GO:0001973)3.31969544
35dopamine transport (GO:0015872)3.29215237
36regulation of memory T cell differentiation (GO:0043380)3.28574233
37negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.26167740
38purinergic receptor signaling pathway (GO:0035587)3.22290983
39neutrophil activation (GO:0042119)3.20675290
40positive regulation of mast cell activation (GO:0033005)3.18640539
41G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.17842217
42lipoxygenase pathway (GO:0019372)3.17612405
43regulation of integrin activation (GO:0033623)3.16055191
44adenosine metabolic process (GO:0046085)3.09642384
45sequestering of actin monomers (GO:0042989)3.07866278
46negative regulation of calcium ion transport into cytosol (GO:0010523)3.07683412
47regulation of endothelial cell differentiation (GO:0045601)3.05908838
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01777296
49regulation of macrophage derived foam cell differentiation (GO:0010743)3.00550550
50positive regulation of Rho protein signal transduction (GO:0035025)3.00127738
51regulation of MHC class II biosynthetic process (GO:0045346)2.98410163
52regulation of female receptivity (GO:0045924)2.97247049
53regulation of Golgi to plasma membrane protein transport (GO:0042996)2.94937562
54plasma membrane fusion (GO:0045026)2.94834986
55negative regulation of T cell apoptotic process (GO:0070233)2.94209042
56mitochondrial calcium ion transport (GO:0006851)2.93613279
57phosphatidylinositol acyl-chain remodeling (GO:0036149)2.92091054
58high-density lipoprotein particle remodeling (GO:0034375)2.91619339
59polyamine biosynthetic process (GO:0006596)2.88108268
60negative regulation of neural precursor cell proliferation (GO:2000178)2.85215410
61granulocyte activation (GO:0036230)2.84828947
62regulation of T-helper 1 cell differentiation (GO:0045625)2.84563152
63reverse cholesterol transport (GO:0043691)2.84028870
64pyrimidine nucleoside catabolic process (GO:0046135)2.82644808
65regulation of sensory perception of pain (GO:0051930)2.79339570
66regulation of sensory perception (GO:0051931)2.79339570
67sulfation (GO:0051923)2.78290623
68regulation of regulatory T cell differentiation (GO:0045589)2.77235043
69negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.76002306
70negative regulation of calcium ion transmembrane transport (GO:1903170)2.76002306
71negative regulation of homotypic cell-cell adhesion (GO:0034111)2.72481908
72positive regulation of macrophage differentiation (GO:0045651)2.71846281
73regulation of norepinephrine secretion (GO:0014061)2.70248109
74autophagic vacuole fusion (GO:0000046)2.69769678
75positive regulation of protein homodimerization activity (GO:0090073)2.68215417
76superoxide anion generation (GO:0042554)2.67246867
77platelet degranulation (GO:0002576)2.65472529
78negative regulation of alpha-beta T cell differentiation (GO:0046639)2.65357644
79parturition (GO:0007567)2.65246337
80negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.64312431
81termination of G-protein coupled receptor signaling pathway (GO:0038032)2.62121740
82rhodopsin mediated signaling pathway (GO:0016056)2.59985059
83regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58446819
84cellular biogenic amine biosynthetic process (GO:0042401)2.58335581
85negative regulation of cation channel activity (GO:2001258)2.56316903
86megakaryocyte development (GO:0035855)2.55578974
87activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.54636743
88mitochondrial calcium ion homeostasis (GO:0051560)2.54112809
89female mating behavior (GO:0060180)2.53797040
90regulation of homotypic cell-cell adhesion (GO:0034110)2.53026753
91amine biosynthetic process (GO:0009309)2.51265014
92multicellular organism reproduction (GO:0032504)2.50534889
93DNA deamination (GO:0045006)2.49681031
94regulation of thymocyte apoptotic process (GO:0070243)2.47155442
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46915573
96monoamine transport (GO:0015844)2.46856822
97negative regulation of heart contraction (GO:0045822)2.46466407
98nitric oxide mediated signal transduction (GO:0007263)2.46064748
99positive regulation of hemostasis (GO:1900048)2.45805950
100positive regulation of blood coagulation (GO:0030194)2.45805950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.29610447
2VDR_22108803_ChIP-Seq_LS180_Human3.27933923
3GBX2_23144817_ChIP-Seq_PC3_Human2.96429440
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.90212299
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64516532
6SCL_19346495_ChIP-Seq_HPC-7_Human2.58453494
7IGF1R_20145208_ChIP-Seq_DFB_Human2.52294226
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33194071
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21815257
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08796688
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.04855482
12ZNF274_21170338_ChIP-Seq_K562_Hela2.02969516
13GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.00563249
14TAF15_26573619_Chip-Seq_HEK293_Human1.94383190
15LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.89267240
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85635325
17EWS_26573619_Chip-Seq_HEK293_Human1.83430262
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82978607
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.82812664
20EZH2_22144423_ChIP-Seq_EOC_Human1.81977979
21P300_19829295_ChIP-Seq_ESCs_Human1.79743061
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71183770
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70943396
24BCAT_22108803_ChIP-Seq_LS180_Human1.70642937
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66842175
26HTT_18923047_ChIP-ChIP_STHdh_Human1.66577126
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64397834
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62360529
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60775344
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.58250187
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57991999
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55828933
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53443497
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53443497
35ER_23166858_ChIP-Seq_MCF-7_Human1.49474535
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47574131
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47300018
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47133372
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.45044633
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.44957906
41NANOG_19829295_ChIP-Seq_ESCs_Human1.44229577
42SOX2_19829295_ChIP-Seq_ESCs_Human1.44229577
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43820215
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41612320
45AR_25329375_ChIP-Seq_VCAP_Human1.40711560
46GATA1_19941826_ChIP-Seq_K562_Human1.40020940
47SMAD4_21799915_ChIP-Seq_A2780_Human1.39097863
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37089101
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37085636
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31308268
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30655387
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30073244
53GATA2_19941826_ChIP-Seq_K562_Human1.29993349
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27774669
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27070720
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23889838
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.22644509
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21949146
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21090244
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.20960593
61SALL4_22934838_ChIP-ChIP_CD34+_Human1.19852120
62AR_20517297_ChIP-Seq_VCAP_Human1.19011844
63IRF1_19129219_ChIP-ChIP_H3396_Human1.18830095
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18824978
65CDX2_22108803_ChIP-Seq_LS180_Human1.18650278
66STAT3_23295773_ChIP-Seq_U87_Human1.18572895
67GATA1_22025678_ChIP-Seq_K562_Human1.18220433
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.18018173
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17465570
70TCF4_23295773_ChIP-Seq_U87_Human1.15817378
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14097237
72TCF4_22108803_ChIP-Seq_LS180_Human1.12229942
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12078561
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.12078561
75P53_22387025_ChIP-Seq_ESCs_Mouse1.10016219
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09901839
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09731762
78TP53_22573176_ChIP-Seq_HFKS_Human1.09421375
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09056680
80* SMAD4_21741376_ChIP-Seq_EPCs_Human1.08700494
81* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08684078
82GATA3_26560356_Chip-Seq_TH2_Human1.07840369
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07401918
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05232970
85ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03791639
86* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03370793
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.01580691
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.01275413
89* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01191752
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.97736219
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97620351
92CBP_20019798_ChIP-Seq_JUKART_Human0.97620351
93* SMRT_27268052_Chip-Seq_Bcells_Human0.96928255
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96821745
95FUS_26573619_Chip-Seq_HEK293_Human0.95945411
96* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95906368
97STAT1_20625510_ChIP-Seq_HELA_Human0.95737258
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.95495997
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.95244561
100ERG_20517297_ChIP-Seq_VCAP_Human0.94660686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.26164399
2MP0008004_abnormal_stomach_pH4.43538220
3MP0005084_abnormal_gallbladder_morpholo3.05947504
4MP0003724_increased_susceptibility_to3.02489320
5MP0000465_gastrointestinal_hemorrhage2.94457885
6MP0005646_abnormal_pituitary_gland2.42108793
7MP0000230_abnormal_systemic_arterial2.32452499
8MP0002736_abnormal_nociception_after2.29011891
9MP0005167_abnormal_blood-brain_barrier2.26953939
10MP0008872_abnormal_physiological_respon2.26049821
11MP0001879_abnormal_lymphatic_vessel2.23622636
12MP0010386_abnormal_urinary_bladder2.19696660
13MP0005083_abnormal_biliary_tract2.04789179
14MP0003011_delayed_dark_adaptation2.01985083
15MP0004084_abnormal_cardiac_muscle2.01595443
16MP0002148_abnormal_hypersensitivity_rea1.95308141
17MP0005410_abnormal_fertilization1.95224229
18MP0000343_altered_response_to1.94003677
19MP0008775_abnormal_heart_ventricle1.88807767
20MP0002102_abnormal_ear_morphology1.85841022
21MP0000372_irregular_coat_pigmentation1.84864738
22MP0001968_abnormal_touch/_nociception1.78257466
23MP0001835_abnormal_antigen_presentation1.76342922
24MP0006054_spinal_hemorrhage1.72154911
25MP0005671_abnormal_response_to1.69454593
26MP0004215_abnormal_myocardial_fiber1.67507025
27MP0003828_pulmonary_edema1.64535753
28MP0009764_decreased_sensitivity_to1.50595624
29MP0010368_abnormal_lymphatic_system1.48933824
30MP0006276_abnormal_autonomic_nervous1.43556075
31MP0001545_abnormal_hematopoietic_system1.43406438
32MP0005397_hematopoietic_system_phenotyp1.43406438
33MP0003638_abnormal_response/metabolism_1.40372457
34MP0002733_abnormal_thermal_nociception1.39291839
35MP0003718_maternal_effect1.37069089
36MP0002138_abnormal_hepatobiliary_system1.36205212
37MP0004036_abnormal_muscle_relaxation1.36122466
38MP0004510_myositis1.35518627
39MP0004484_altered_response_of1.25390400
40MP0005551_abnormal_eye_electrophysiolog1.22746790
41MP0008875_abnormal_xenobiotic_pharmacok1.19016155
42MP0009697_abnormal_copulation1.18189374
43MP0004147_increased_porphyrin_level1.17633786
44MP0010155_abnormal_intestine_physiology1.13397130
45MP0009765_abnormal_xenobiotic_induced1.10062066
46MP0008877_abnormal_DNA_methylation1.08762801
47MP0000249_abnormal_blood_vessel1.06291109
48MP0005000_abnormal_immune_tolerance1.05431599
49MP0003806_abnormal_nucleotide_metabolis1.05109244
50MP0001905_abnormal_dopamine_level1.05027579
51MP0001663_abnormal_digestive_system1.04574572
52MP0009763_increased_sensitivity_to1.03405748
53MP0004142_abnormal_muscle_tone1.02165108
54MP0003186_abnormal_redox_activity1.02087715
55MP0005253_abnormal_eye_physiology0.97054989
56MP0002876_abnormal_thyroid_physiology0.96016380
57MP0001756_abnormal_urination0.95423107
58MP0010329_abnormal_lipoprotein_level0.94786315
59MP0001970_abnormal_pain_threshold0.93523903
60MP0004130_abnormal_muscle_cell0.92610195
61MP0005365_abnormal_bile_salt0.92463405
62MP0002723_abnormal_immune_serum0.90166622
63MP0005174_abnormal_tail_pigmentation0.88024521
64MP0005645_abnormal_hypothalamus_physiol0.87819371
65MP0005165_increased_susceptibility_to0.86549875
66MP0003879_abnormal_hair_cell0.86011282
67MP0006036_abnormal_mitochondrial_physio0.85349276
68MP0005647_abnormal_sex_gland0.84997076
69MP0002735_abnormal_chemical_nociception0.84717933
70MP0002452_abnormal_antigen_presenting0.83237933
71MP0002398_abnormal_bone_marrow0.80401968
72MP0000685_abnormal_immune_system0.80258421
73MP0003195_calcinosis0.79152434
74MP0009046_muscle_twitch0.79041335
75MP0002972_abnormal_cardiac_muscle0.78507245
76MP0002132_abnormal_respiratory_system0.77518519
77MP0005595_abnormal_vascular_smooth0.77076973
78MP0002638_abnormal_pupillary_reflex0.76698678
79MP0000383_abnormal_hair_follicle0.76209401
80MP0000689_abnormal_spleen_morphology0.76160597
81MP0001800_abnormal_humoral_immune0.75678405
82MP0005385_cardiovascular_system_phenoty0.74309253
83MP0001544_abnormal_cardiovascular_syste0.74309253
84MP0009642_abnormal_blood_homeostasis0.73786708
85MP0005085_abnormal_gallbladder_physiolo0.73725335
86MP0003303_peritoneal_inflammation0.73470048
87MP0005620_abnormal_muscle_contractility0.73283532
88MP0004085_abnormal_heartbeat0.72439636
89MP0002837_dystrophic_cardiac_calcinosis0.72416084
90MP0003136_yellow_coat_color0.71577981
91MP0001851_eye_inflammation0.71392461
92MP0003656_abnormal_erythrocyte_physiolo0.71246423
93MP0001765_abnormal_ion_homeostasis0.71111882
94MP0003950_abnormal_plasma_membrane0.70996022
95MP0005058_abnormal_lysosome_morphology0.70494292
96MP0001845_abnormal_inflammatory_respons0.68490552
97MP0005389_reproductive_system_phenotype0.67186380
98MP0005171_absent_coat_pigmentation0.65817185
99MP0005187_abnormal_penis_morphology0.65176348
100MP0002429_abnormal_blood_cell0.65070356

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.62292428
2Menorrhagia (HP:0000132)7.53003134
3Petechiae (HP:0000967)7.22322694
4Increased mean platelet volume (HP:0011877)7.15849865
5Abnormal platelet volume (HP:0011876)6.53790064
6Purpura (HP:0000979)6.09484410
7Epistaxis (HP:0000421)5.64010151
8Hyperlipoproteinemia (HP:0010980)4.69274913
9Gingival bleeding (HP:0000225)4.50666400
10Decreased central vision (HP:0007663)4.16211155
11Abnormal platelet function (HP:0011869)3.71373589
12Impaired platelet aggregation (HP:0003540)3.71373589
13Dyschromatopsia (HP:0007641)3.63231782
14Stomatitis (HP:0010280)3.45277864
15Thyroid-stimulating hormone excess (HP:0002925)3.41276050
16Abnormal pupillary function (HP:0007686)3.08638497
17Conjunctival telangiectasia (HP:0000524)2.95185372
18Poikilocytosis (HP:0004447)2.92435554
19Abolished electroretinogram (ERG) (HP:0000550)2.89019753
20Abnormality of the heme biosynthetic pathway (HP:0010472)2.87869237
21Spontaneous hematomas (HP:0007420)2.82154051
22Abnormality of the vasculature of the conjunctiva (HP:0008054)2.81798371
23Paralysis (HP:0003470)2.80611637
24Abnormality of lateral ventricle (HP:0030047)2.77058292
25Pancreatic cysts (HP:0001737)2.63894963
26Renal cortical cysts (HP:0000803)2.60586790
27Congenital stationary night blindness (HP:0007642)2.51731749
28Generalized aminoaciduria (HP:0002909)2.50642467
29Acanthocytosis (HP:0001927)2.45943051
30Bruising susceptibility (HP:0000978)2.44348299
31Abnormality of alanine metabolism (HP:0010916)2.37440612
32Hyperalaninemia (HP:0003348)2.37440612
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37440612
34Abnormality of the prostate (HP:0008775)2.36954167
35Abnormal auditory evoked potentials (HP:0006958)2.35212771
36Tinnitus (HP:0000360)2.34768245
37Abnormality of the renal cortex (HP:0011035)2.34371271
383-Methylglutaconic aciduria (HP:0003535)2.34053318
39Abnormal drinking behavior (HP:0030082)2.32195453
40Polydipsia (HP:0001959)2.32195453
41Congenital sensorineural hearing impairment (HP:0008527)2.25814028
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25548222
43Joint swelling (HP:0001386)2.15571290
44Type 2 muscle fiber atrophy (HP:0003554)2.15553620
45Hypomagnesemia (HP:0002917)2.13783850
46Abnormality of transition element cation homeostasis (HP:0011030)2.12751661
47Pancreatic fibrosis (HP:0100732)2.10838581
48Tongue fasciculations (HP:0001308)2.08776424
49Renal Fanconi syndrome (HP:0001994)2.06963281
50True hermaphroditism (HP:0010459)2.05678214
51Abnormal ciliary motility (HP:0012262)2.05656787
52Attenuation of retinal blood vessels (HP:0007843)2.05134662
53Abnormal rod and cone electroretinograms (HP:0008323)2.02293885
54Increased density of long bones (HP:0006392)1.99799249
55Increased IgM level (HP:0003496)1.94415769
56Central scotoma (HP:0000603)1.94231922
57Gaze-evoked nystagmus (HP:0000640)1.92968241
58Hypothermia (HP:0002045)1.91340958
59Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89624474
60Abnormality of iron homeostasis (HP:0011031)1.88877699
61Increased corneal curvature (HP:0100692)1.88860498
62Keratoconus (HP:0000563)1.88860498
63Abnormal respiratory epithelium morphology (HP:0012253)1.88784117
64Abnormal respiratory motile cilium morphology (HP:0005938)1.88784117
65Abnormality of midbrain morphology (HP:0002418)1.86081799
66Molar tooth sign on MRI (HP:0002419)1.86081799
67Nausea (HP:0002018)1.85064122
68Autoimmune hemolytic anemia (HP:0001890)1.84934501
69Hypoplastic iliac wings (HP:0002866)1.78879948
70Abnormality of the common coagulation pathway (HP:0010990)1.78638811
71Biliary tract neoplasm (HP:0100574)1.78143507
72Hypoplasia of the fovea (HP:0007750)1.77937122
73Aplasia/Hypoplasia of the fovea (HP:0008060)1.77937122
74Hepatosplenomegaly (HP:0001433)1.76434386
75Muscle fibrillation (HP:0010546)1.73184587
76Congenital, generalized hypertrichosis (HP:0004540)1.73101824
77Upper limb muscle weakness (HP:0003484)1.72334843
78Muscle fiber atrophy (HP:0100295)1.72163992
79Spontaneous abortion (HP:0005268)1.72064798
80Polyuria (HP:0000103)1.71482297
81Clumsiness (HP:0002312)1.70683784
82Disproportionate short-trunk short stature (HP:0003521)1.70622424
83Hypoproteinemia (HP:0003075)1.70449020
84Visual hallucinations (HP:0002367)1.67681303
85Episodic fever (HP:0001954)1.65772903
86Abnormality of the fovea (HP:0000493)1.64752220
87Exertional dyspnea (HP:0002875)1.63422801
88Abnormality of magnesium homeostasis (HP:0004921)1.63233159
89Eosinophilia (HP:0001880)1.61952026
90Dynein arm defect of respiratory motile cilia (HP:0012255)1.61235691
91Absent/shortened dynein arms (HP:0200106)1.61235691
92Hypophosphatemic rickets (HP:0004912)1.60766922
93Dysautonomia (HP:0002459)1.60715943
94Male infertility (HP:0003251)1.60059972
95Ventricular fibrillation (HP:0001663)1.59249635
96Albinism (HP:0001022)1.59144237
97IgG deficiency (HP:0004315)1.58095927
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.54978829
99Fibular aplasia (HP:0002990)1.54669983
100Cerebral hemorrhage (HP:0001342)1.52821746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.84666786
2TAOK33.63814387
3FRK2.95835169
4MYLK2.85361008
5TEC2.59602298
6ADRBK22.54745118
7MAP4K22.53752448
8PIK3CG2.37931122
9NUAK12.19310756
10BMPR1B2.09154252
11PTK2B2.04221739
12TRIM281.89679236
13BMX1.88549937
14BTK1.85342716
15TIE11.70539239
16ZAK1.69073085
17MAPKAPK31.68764224
18EIF2AK11.66159288
19TXK1.65296020
20GRK51.63010502
21ACVR1B1.56300388
22SYK1.54130077
23PLK21.50327433
24TLK11.49887683
25IKBKB1.48617403
26CSF1R1.46472055
27BCKDK1.44120267
28INSRR1.39878891
29GRK11.35666362
30FER1.27241131
31BMPR21.23187584
32STK31.17476576
33PKN11.16049441
34EPHA31.16047445
35ADRBK11.12813839
36ZAP701.11432779
37DAPK21.06144065
38WNK41.05994611
39PIM21.05504713
40RIPK41.05046502
41ILK1.04046563
42FES1.03973571
43PINK11.00898235
44MAPK130.97904568
45STK390.93414131
46ITK0.92757887
47KDR0.86959829
48IRAK10.86428767
49HCK0.81899008
50LYN0.80147010
51DAPK30.79213195
52TNK20.78863213
53GRK70.77557036
54MAP3K50.74954928
55CSNK1G30.74127354
56PRKCE0.73794197
57EPHB20.73448550
58BRSK20.72482973
59BCR0.70700224
60CSNK1G10.70243728
61ERBB20.69209753
62TNIK0.69003705
63PRKCQ0.68457426
64FLT30.66571615
65FGR0.65296702
66PAK30.64817936
67MAP3K120.64465395
68MATK0.64073707
69GRK60.63614708
70MARK30.62444976
71ABL20.61060444
72DAPK10.60961507
73CSNK1G20.59551505
74NLK0.56952940
75IGF1R0.56502089
76BLK0.56475708
77PRKD10.56358732
78VRK10.54751057
79PAK10.54443607
80SIK30.53915158
81MUSK0.52670820
82KIT0.52663222
83WNK30.51769964
84DYRK20.50376964
85STK38L0.49968207
86MINK10.49268362
87MAP2K70.49008332
88OXSR10.48728850
89CAMKK20.47598223
90PIK3CA0.46498760
91CAMK2A0.46076167
92RPS6KA50.45820955
93TGFBR10.42920325
94OBSCN0.42633892
95PHKG10.40392101
96PHKG20.40392101
97ERBB30.39696040
98LCK0.38812807
99PRKCA0.38773170
100ABL10.38672332

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.85453957
2SNARE interactions in vesicular transport_Homo sapiens_hsa041302.97956732
3Nitrogen metabolism_Homo sapiens_hsa009102.80428504
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.60905638
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32376344
6Arachidonic acid metabolism_Homo sapiens_hsa005902.28001442
7Hematopoietic cell lineage_Homo sapiens_hsa046402.19812793
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13751533
9Linoleic acid metabolism_Homo sapiens_hsa005912.07378999
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.05387660
11Phototransduction_Homo sapiens_hsa047442.05202792
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88163196
13Asthma_Homo sapiens_hsa053101.83834632
14Collecting duct acid secretion_Homo sapiens_hsa049661.81893470
15Sulfur metabolism_Homo sapiens_hsa009201.80997312
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.68916582
17Serotonergic synapse_Homo sapiens_hsa047261.63724808
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60248690
19Allograft rejection_Homo sapiens_hsa053301.56633679
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55289550
21ECM-receptor interaction_Homo sapiens_hsa045121.52386578
22Autoimmune thyroid disease_Homo sapiens_hsa053201.50899676
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47842465
24Graft-versus-host disease_Homo sapiens_hsa053321.46509305
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.45482285
26Olfactory transduction_Homo sapiens_hsa047401.43449844
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32283411
28Fatty acid elongation_Homo sapiens_hsa000621.31515876
29Glycerolipid metabolism_Homo sapiens_hsa005611.31335256
30Rheumatoid arthritis_Homo sapiens_hsa053231.29926607
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27161009
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.26458642
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26302170
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24956975
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22075204
36Chemical carcinogenesis_Homo sapiens_hsa052041.15170345
37Regulation of autophagy_Homo sapiens_hsa041401.07558260
38Glutathione metabolism_Homo sapiens_hsa004801.06009708
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.04528177
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03575692
41Systemic lupus erythematosus_Homo sapiens_hsa053220.98327487
42Morphine addiction_Homo sapiens_hsa050320.98314326
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98102627
44Primary immunodeficiency_Homo sapiens_hsa053400.94295813
45Chemokine signaling pathway_Homo sapiens_hsa040620.93920800
46Type I diabetes mellitus_Homo sapiens_hsa049400.93155044
47Pancreatic secretion_Homo sapiens_hsa049720.90304002
48Ether lipid metabolism_Homo sapiens_hsa005650.89412491
49One carbon pool by folate_Homo sapiens_hsa006700.88890321
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88622223
51Homologous recombination_Homo sapiens_hsa034400.84848716
52Retinol metabolism_Homo sapiens_hsa008300.82957487
53Circadian entrainment_Homo sapiens_hsa047130.82572622
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79834890
55Mismatch repair_Homo sapiens_hsa034300.79189776
56Tryptophan metabolism_Homo sapiens_hsa003800.79019466
57beta-Alanine metabolism_Homo sapiens_hsa004100.76212034
58Calcium signaling pathway_Homo sapiens_hsa040200.75551488
59Ovarian steroidogenesis_Homo sapiens_hsa049130.74446418
60Peroxisome_Homo sapiens_hsa041460.73971230
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.69516296
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68179263
63Purine metabolism_Homo sapiens_hsa002300.67644243
64Alcoholism_Homo sapiens_hsa050340.63992033
65Basal transcription factors_Homo sapiens_hsa030220.61442060
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59164473
67Protein export_Homo sapiens_hsa030600.59161782
68Shigellosis_Homo sapiens_hsa051310.59059851
69GABAergic synapse_Homo sapiens_hsa047270.58677196
70Gap junction_Homo sapiens_hsa045400.57432718
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57008386
72Phagosome_Homo sapiens_hsa041450.55641380
73Fat digestion and absorption_Homo sapiens_hsa049750.55616964
74Sphingolipid metabolism_Homo sapiens_hsa006000.55285452
75ABC transporters_Homo sapiens_hsa020100.52829062
76Propanoate metabolism_Homo sapiens_hsa006400.51817245
77Taste transduction_Homo sapiens_hsa047420.50913191
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50788267
79Fanconi anemia pathway_Homo sapiens_hsa034600.49749602
80Endocytosis_Homo sapiens_hsa041440.49551198
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49364966
82Salivary secretion_Homo sapiens_hsa049700.49357244
83Starch and sucrose metabolism_Homo sapiens_hsa005000.49135587
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48365413
85Butanoate metabolism_Homo sapiens_hsa006500.48360533
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.48278676
87RNA polymerase_Homo sapiens_hsa030200.48081416
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47466859
89Parkinsons disease_Homo sapiens_hsa050120.46830721
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46828389
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44589670
92Caffeine metabolism_Homo sapiens_hsa002320.43399247
93Ras signaling pathway_Homo sapiens_hsa040140.38462978
94Lysosome_Homo sapiens_hsa041420.38409197
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38165116
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37998833
97Selenocompound metabolism_Homo sapiens_hsa004500.37604373
98Malaria_Homo sapiens_hsa051440.36203665
99Oxidative phosphorylation_Homo sapiens_hsa001900.36089054
100Long-term depression_Homo sapiens_hsa047300.35614865

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