LIN28A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.77980078
2* regulation of posttranscriptional gene silencing (GO:0060147)5.63796296
3* regulation of gene silencing by miRNA (GO:0060964)5.63796296
4* regulation of gene silencing by RNA (GO:0060966)5.63796296
5nuclear pore complex assembly (GO:0051292)5.44330220
6paraxial mesoderm development (GO:0048339)4.91112425
7DNA unwinding involved in DNA replication (GO:0006268)4.90370466
8L-serine metabolic process (GO:0006563)4.87367657
9regulation of cell fate specification (GO:0042659)4.86796759
10DNA replication-dependent nucleosome organization (GO:0034723)4.78741537
11DNA replication-dependent nucleosome assembly (GO:0006335)4.78741537
12* pre-miRNA processing (GO:0031054)4.71334010
13establishment of viral latency (GO:0019043)4.53943747
14folic acid-containing compound biosynthetic process (GO:0009396)4.46323078
15protein localization to kinetochore (GO:0034501)4.38950668
16mitotic nuclear envelope disassembly (GO:0007077)4.33910045
17IMP biosynthetic process (GO:0006188)4.28451767
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.20189357
19negative regulation of translation, ncRNA-mediated (GO:0040033)4.20189357
20regulation of translation, ncRNA-mediated (GO:0045974)4.20189357
21DNA replication initiation (GO:0006270)4.15524557
22mitotic metaphase plate congression (GO:0007080)4.07890679
23nuclear envelope disassembly (GO:0051081)4.06885940
24membrane disassembly (GO:0030397)4.06885940
25heterochromatin organization (GO:0070828)4.06106754
26pore complex assembly (GO:0046931)4.01354947
27regulation of helicase activity (GO:0051095)3.99950488
28nucleobase biosynthetic process (GO:0046112)3.97471062
29regulation of histone H3-K9 methylation (GO:0051570)3.97384010
30negative regulation of gene silencing (GO:0060969)3.95402489
31negative regulation of histone methylation (GO:0031061)3.86985434
32mitotic sister chromatid segregation (GO:0000070)3.86268230
33regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.84157531
34lung-associated mesenchyme development (GO:0060484)3.81137691
35ribosome assembly (GO:0042255)3.77474068
36notochord development (GO:0030903)3.76586078
37cell fate commitment involved in formation of primary germ layer (GO:0060795)3.76539805
38peptidyl-arginine omega-N-methylation (GO:0035247)3.75089785
39IMP metabolic process (GO:0046040)3.71976001
40convergent extension (GO:0060026)3.68408403
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.67723439
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.67723439
43DNA geometric change (GO:0032392)3.66425406
44DNA duplex unwinding (GO:0032508)3.66109133
45metaphase plate congression (GO:0051310)3.64760579
46DNA strand elongation involved in DNA replication (GO:0006271)3.61172003
47regulation of translational fidelity (GO:0006450)3.60816412
48regulation of chromatin silencing (GO:0031935)3.60559685
49positive regulation of chromosome segregation (GO:0051984)3.59657440
50regulation of SMAD protein import into nucleus (GO:0060390)3.58910003
51establishment of apical/basal cell polarity (GO:0035089)3.58275813
52sister chromatid segregation (GO:0000819)3.58148480
53protein localization to chromosome, centromeric region (GO:0071459)3.56043511
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52628209
55positive regulation of catenin import into nucleus (GO:0035413)3.52532464
56regulation of sister chromatid cohesion (GO:0007063)3.49235326
57histone arginine methylation (GO:0034969)3.49125889
58positive regulation of SMAD protein import into nucleus (GO:0060391)3.47207478
59purine nucleobase biosynthetic process (GO:0009113)3.46827065
60cellular protein complex localization (GO:0034629)3.46285910
61ATP-dependent chromatin remodeling (GO:0043044)3.46105863
62L-alpha-amino acid transmembrane transport (GO:1902475)3.46011786
63DNA strand elongation (GO:0022616)3.41379805
64regulation of translational termination (GO:0006449)3.39415412
65chromatin assembly (GO:0031497)3.37874980
66histone H2A monoubiquitination (GO:0035518)3.37307768
67mitotic chromosome condensation (GO:0007076)3.36298033
68regulation of centrosome cycle (GO:0046605)3.34645140
69protein K6-linked ubiquitination (GO:0085020)3.34051955
70nucleosome disassembly (GO:0006337)3.32597446
71protein-DNA complex disassembly (GO:0032986)3.32597446
72formation of translation preinitiation complex (GO:0001731)3.32595532
73regulation of cell fate commitment (GO:0010453)3.32421410
74* regulation of gene silencing (GO:0060968)3.28673821
75negative regulation of androgen receptor signaling pathway (GO:0060766)3.26796254
76negative regulation of cell fate specification (GO:0009996)3.26697152
77peptidyl-arginine methylation (GO:0018216)3.25337450
78peptidyl-arginine N-methylation (GO:0035246)3.25337450
79chromatin remodeling at centromere (GO:0031055)3.24438726
80regulation of centriole replication (GO:0046599)3.22156404
81kinetochore organization (GO:0051383)3.21655062
82regulation of stem cell maintenance (GO:2000036)3.20768564
83positive regulation of mitotic sister chromatid separation (GO:1901970)3.20267709
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20267709
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20267709
86DNA replication checkpoint (GO:0000076)3.19220876
87planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18131716
88anterior/posterior axis specification, embryo (GO:0008595)3.17686548
89mitotic sister chromatid cohesion (GO:0007064)3.17650422
90regulation of telomere maintenance via telomerase (GO:0032210)3.17522581
91regulation of spindle organization (GO:0090224)3.16299708
92establishment of chromosome localization (GO:0051303)3.14559716
93regulation of chromosome segregation (GO:0051983)3.14023358
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13292748
95negative regulation of chromosome segregation (GO:0051985)3.12767621
96regulation of hippo signaling (GO:0035330)3.11201710
97ribosome biogenesis (GO:0042254)3.10989210
98nuclear envelope organization (GO:0006998)3.07879233
99polarized epithelial cell differentiation (GO:0030859)3.07174868
100DNA replication-independent nucleosome assembly (GO:0006336)3.06570685
101DNA replication-independent nucleosome organization (GO:0034724)3.06570685
102establishment of monopolar cell polarity (GO:0061162)3.04877693
103establishment or maintenance of monopolar cell polarity (GO:0061339)3.04877693
104chromatin assembly or disassembly (GO:0006333)3.04524543
105histone H4-K12 acetylation (GO:0043983)3.04423148
106dosage compensation (GO:0007549)3.02934808
107maturation of SSU-rRNA (GO:0030490)3.02701757
108regulation of RNA export from nucleus (GO:0046831)3.02637033
109regulation of mitotic spindle checkpoint (GO:1903504)3.02565664
110regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02565664
111mRNA transport (GO:0051028)3.02462548
112CENP-A containing nucleosome assembly (GO:0034080)3.02431432
113telomere maintenance via semi-conservative replication (GO:0032201)3.01504521
114spliceosomal tri-snRNP complex assembly (GO:0000244)3.01121737
115spindle checkpoint (GO:0031577)3.01060910
116negative regulation of mitotic sister chromatid separation (GO:2000816)3.00757557
117negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00757557
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00757557
119negative regulation of sister chromatid segregation (GO:0033046)3.00757557
120serine family amino acid biosynthetic process (GO:0009070)3.00302197
121mitotic spindle checkpoint (GO:0071174)2.99906212
122establishment of integrated proviral latency (GO:0075713)2.99325938
123non-recombinational repair (GO:0000726)2.98727363
124double-strand break repair via nonhomologous end joining (GO:0006303)2.98727363
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98647032
126histone exchange (GO:0043486)2.98476412
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97083430
128negative regulation of cell fate commitment (GO:0010454)2.96896046
129DNA ligation (GO:0006266)2.96122547
130regulation of mitotic spindle organization (GO:0060236)2.95816986
131protein complex localization (GO:0031503)2.95512086
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94696269
133spindle assembly checkpoint (GO:0071173)2.94237582
134positive regulation of cell cycle G2/M phase transition (GO:1902751)2.90706932
135positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.90706932
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90374625
137dorsal/ventral axis specification (GO:0009950)2.88945920
138DNA damage response, detection of DNA damage (GO:0042769)2.84325953
139negative regulation of RNA splicing (GO:0033119)2.81873059
140outer ear morphogenesis (GO:0042473)2.78689177
141lysine metabolic process (GO:0006553)2.77915485
142lysine catabolic process (GO:0006554)2.77915485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25311934
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.74466576
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.16544818
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84213846
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24563220
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13498828
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.87192141
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.87192141
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.87192141
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78867897
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75657263
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.64348617
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63218658
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.53489725
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.49562003
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35052075
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33155113
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25164268
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.18656891
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18041020
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.16473099
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13524312
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.11750335
24AR_21909140_ChIP-Seq_LNCAP_Human2.10622362
25* XRN2_22483619_ChIP-Seq_HELA_Human2.05990865
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05554237
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02361252
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01030208
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.99846737
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.99158741
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.97991017
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.97292472
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94453076
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.93035656
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.86628140
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.86397424
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.83820434
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.77260920
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76119286
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73988457
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71783151
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70075062
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66690391
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65238604
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.63099964
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.59877434
47MYC_22102868_ChIP-Seq_BL_Human1.56993423
48* TTF2_22483619_ChIP-Seq_HELA_Human1.53400593
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.51695335
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50450331
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48919309
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48445085
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40522582
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40258345
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40105673
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39667014
57VDR_23849224_ChIP-Seq_CD4+_Human1.38379468
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.37824745
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37453085
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.37300624
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37217091
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35460348
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33887643
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32398196
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32345641
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32336065
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31402350
68FOXP3_21729870_ChIP-Seq_TREG_Human1.29921016
69KDM5A_27292631_Chip-Seq_BREAST_Human1.29791940
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29775443
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27741429
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27595944
73GABP_19822575_ChIP-Seq_HepG2_Human1.24834196
74SOX2_18692474_ChIP-Seq_MESCs_Mouse1.24181902
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22955642
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21714059
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21549485
78DCP1A_22483619_ChIP-Seq_HELA_Human1.21030265
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20361873
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19746137
81MYC_18940864_ChIP-ChIP_HL60_Human1.17622201
82CIITA_25753668_ChIP-Seq_RAJI_Human1.16173345
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14839709
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08716024
85ELK1_19687146_ChIP-ChIP_HELA_Human1.08498700
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08478054
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06292306
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.06053148
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05201547
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05051695
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04440714
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.03322582
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03243360
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.03171090
95NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02551871
96POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02406246
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02057522
98TFEB_21752829_ChIP-Seq_HELA_Human1.02024821
99NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01010051
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00086811
101KAP1_27257070_Chip-Seq_ESCs_Mouse0.99910860
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98979168
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97803264
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.97733386
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97623719
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97316992
107* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96532831
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95640911
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94268425
110NANOG_16518401_ChIP-PET_MESCs_Mouse0.93875650
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92755169
112IRF1_19129219_ChIP-ChIP_H3396_Human0.92304909
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92208091
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91288733
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.89495273
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89251913
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86746762
118EWS_26573619_Chip-Seq_HEK293_Human0.85503354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.88969292
2MP0004957_abnormal_blastocyst_morpholog3.99260044
3MP0003693_abnormal_embryo_hatching3.97993201
4MP0010094_abnormal_chromosome_stability3.84651991
5MP0003111_abnormal_nucleus_morphology3.77963171
6MP0003123_paternal_imprinting3.50624515
7MP0008057_abnormal_DNA_replication3.47637837
8MP0003077_abnormal_cell_cycle3.37829847
9MP0001730_embryonic_growth_arrest2.68014645
10MP0003890_abnormal_embryonic-extraembry2.65166995
11MP0010030_abnormal_orbit_morphology2.52884319
12MP0010352_gastrointestinal_tract_polyps2.49471057
13MP0008058_abnormal_DNA_repair2.42827619
14MP0008932_abnormal_embryonic_tissue2.38944749
15MP0002084_abnormal_developmental_patter2.34180821
16MP0003119_abnormal_digestive_system2.30521385
17MP0003121_genomic_imprinting2.30051818
18MP0003941_abnormal_skin_development2.29873326
19MP0000350_abnormal_cell_proliferation2.27219519
20MP0002653_abnormal_ependyma_morphology2.22230430
21MP0001672_abnormal_embryogenesis/_devel2.22140191
22MP0005380_embryogenesis_phenotype2.22140191
23MP0002085_abnormal_embryonic_tissue2.17192900
24MP0000537_abnormal_urethra_morphology2.15705085
25MP0008877_abnormal_DNA_methylation2.15344948
26MP0004197_abnormal_fetal_growth/weight/2.10401550
27MP0004133_heterotaxia2.08990500
28MP0008007_abnormal_cellular_replicative2.08926949
29MP0001697_abnormal_embryo_size2.06364547
30MP0001293_anophthalmia2.03536731
31MP0003984_embryonic_growth_retardation1.93702245
32MP0005076_abnormal_cell_differentiation1.93296672
33MP0010307_abnormal_tumor_latency1.92262271
34MP0002088_abnormal_embryonic_growth/wei1.91041824
35MP0009053_abnormal_anal_canal1.86008976
36MP0002086_abnormal_extraembryonic_tissu1.83434514
37MP0002080_prenatal_lethality1.69202586
38MP0001299_abnormal_eye_distance/1.68082197
39MP0003567_abnormal_fetal_cardiomyocyte1.67567682
40MP0003705_abnormal_hypodermis_morpholog1.66781212
41MP0003937_abnormal_limbs/digits/tail_de1.63936520
42MP0006292_abnormal_olfactory_placode1.54376589
43MP0003806_abnormal_nucleotide_metabolis1.53911097
44MP0003786_premature_aging1.45598851
45MP0003315_abnormal_perineum_morphology1.39346750
46MP0002111_abnormal_tail_morphology1.38903216
47MP0003283_abnormal_digestive_organ1.31741765
48MP0001188_hyperpigmentation1.30208560
49MP0002697_abnormal_eye_size1.26302401
50MP0001849_ear_inflammation1.25750449
51MP0004264_abnormal_extraembryonic_tissu1.25628576
52* MP0009672_abnormal_birth_weight1.25155563
53MP0003718_maternal_effect1.22457645
54MP0010234_abnormal_vibrissa_follicle1.22294631
55MP0003861_abnormal_nervous_system1.16105417
56MP0000579_abnormal_nail_morphology1.16097605
57MP0005367_renal/urinary_system_phenotyp1.13656026
58MP0000516_abnormal_urinary_system1.13656026
59* MP0009703_decreased_birth_body1.13242712
60MP0001286_abnormal_eye_development1.13009470
61MP0000313_abnormal_cell_death1.10733721
62MP0003787_abnormal_imprinting1.10167475
63MP0000432_abnormal_head_morphology1.09186538
64MP0000428_abnormal_craniofacial_morphol1.07276818
65MP0002210_abnormal_sex_determination1.06929971
66MP0002092_abnormal_eye_morphology1.06577929
67MP0004233_abnormal_muscle_weight1.05604472
68MP0003122_maternal_imprinting1.04325700
69MP0002249_abnormal_larynx_morphology1.03101889
70MP0009697_abnormal_copulation1.01189645
71MP0009379_abnormal_foot_pigmentation1.00789614
72MP0001145_abnormal_male_reproductive0.99272535
73MP0001915_intracranial_hemorrhage0.96226895
74MP0003935_abnormal_craniofacial_develop0.94000691
75MP0002796_impaired_skin_barrier0.93267168
76MP0005623_abnormal_meninges_morphology0.93158758
77MP0002160_abnormal_reproductive_system0.93003993
78MP0005499_abnormal_olfactory_system0.90133898
79MP0005394_taste/olfaction_phenotype0.90133898
80MP0004272_abnormal_basement_membrane0.89601840
81MP0000490_abnormal_crypts_of0.87645365
82MP0000049_abnormal_middle_ear0.87575750
83MP0003566_abnormal_cell_adhesion0.86896616
84MP0002925_abnormal_cardiovascular_devel0.86714155
85MP0001485_abnormal_pinna_reflex0.85955190
86MP0003115_abnormal_respiratory_system0.84492514
87MP0003385_abnormal_body_wall0.82388263
88MP0002089_abnormal_postnatal_growth/wei0.82255887
89MP0000653_abnormal_sex_gland0.81846370
90MP0002019_abnormal_tumor_incidence0.81768484
91MP0003755_abnormal_palate_morphology0.80690528
92MP0001929_abnormal_gametogenesis0.78514077
93MP0009278_abnormal_bone_marrow0.77837720
94MP0003136_yellow_coat_color0.77836000
95MP0002114_abnormal_axial_skeleton0.77167159
96MP0002938_white_spotting0.76557611
97MP0001346_abnormal_lacrimal_gland0.75646761
98MP0001177_atelectasis0.75490906
99MP0000566_synostosis0.75381205
100MP0004185_abnormal_adipocyte_glucose0.75151748
101MP0002932_abnormal_joint_morphology0.74390965
102MP0002751_abnormal_autonomic_nervous0.72973972
103MP0006072_abnormal_retinal_apoptosis0.71658404
104MP0002233_abnormal_nose_morphology0.70856328
105MP0003936_abnormal_reproductive_system0.68561436
106MP0002116_abnormal_craniofacial_bone0.68415372
107MP0000762_abnormal_tongue_morphology0.67503604
108MP0000647_abnormal_sebaceous_gland0.67458339
109MP0005384_cellular_phenotype0.66854097
110MP0000631_abnormal_neuroendocrine_gland0.66375418
111MP0008770_decreased_survivor_rate0.66285676
112MP0005023_abnormal_wound_healing0.66285635
113MP0003938_abnormal_ear_development0.66229657
114MP0000778_abnormal_nervous_system0.65806187
115MP0002152_abnormal_brain_morphology0.65201936
116MP0004858_abnormal_nervous_system0.64944037
117MP0003942_abnormal_urinary_system0.63839141
118MP0008789_abnormal_olfactory_epithelium0.63298987
119MP0005377_hearing/vestibular/ear_phenot0.60924288
120MP0003878_abnormal_ear_physiology0.60924288
121MP0002127_abnormal_cardiovascular_syste0.60178394
122MP0000266_abnormal_heart_morphology0.59695543
123MP0002081_perinatal_lethality0.59527909
124MP0005391_vision/eye_phenotype0.58405298

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.85137656
2Septo-optic dysplasia (HP:0100842)4.37682431
3Hepatoblastoma (HP:0002884)4.11500765
4Medulloblastoma (HP:0002885)4.02815796
5Abnormality of the labia minora (HP:0012880)3.78827665
6Colon cancer (HP:0003003)3.68431413
7Choanal stenosis (HP:0000452)3.50833206
8Spastic diplegia (HP:0001264)3.48782114
9Abnormality of the astrocytes (HP:0100707)3.45314138
10Astrocytoma (HP:0009592)3.45314138
11Absent radius (HP:0003974)3.35810794
12Supernumerary spleens (HP:0009799)3.33189249
13Chromsome breakage (HP:0040012)3.27910565
14Rhabdomyosarcoma (HP:0002859)3.26812800
15Rib fusion (HP:0000902)3.24342280
16Selective tooth agenesis (HP:0001592)3.22147708
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19416684
18Aplasia involving forearm bones (HP:0009822)3.15928900
19Absent forearm bone (HP:0003953)3.15928900
20Bilateral microphthalmos (HP:0007633)3.15298146
21Agnosia (HP:0010524)3.14294419
22Aplasia/hypoplasia of the humerus (HP:0006507)3.13748675
23Neoplasm of the oral cavity (HP:0100649)3.11343661
24Embryonal renal neoplasm (HP:0011794)3.10624164
25Birth length less than 3rd percentile (HP:0003561)3.09107969
26Cortical dysplasia (HP:0002539)3.05759766
27Maternal diabetes (HP:0009800)3.00834979
28Short humerus (HP:0005792)3.00052325
29Partial duplication of thumb phalanx (HP:0009944)2.93835323
30Glioma (HP:0009733)2.88099450
31Missing ribs (HP:0000921)2.87672691
32Neoplasm of striated muscle (HP:0009728)2.82041309
33Impulsivity (HP:0100710)2.75210420
34Breast hypoplasia (HP:0003187)2.73236938
35Abnormality of abdominal situs (HP:0011620)2.72295793
36Abdominal situs inversus (HP:0003363)2.72295793
37Proximal placement of thumb (HP:0009623)2.70936560
38Deviation of the thumb (HP:0009603)2.70258075
39Abnormality of the septum pellucidum (HP:0007375)2.69594898
40Carpal bone hypoplasia (HP:0001498)2.66342144
41Reticulocytopenia (HP:0001896)2.65842869
42Abnormal number of incisors (HP:0011064)2.63155709
43Esophageal atresia (HP:0002032)2.62159448
44Absent septum pellucidum (HP:0001331)2.61580737
45Patellar aplasia (HP:0006443)2.60518528
46Abnormal lung lobation (HP:0002101)2.59124784
47Pseudobulbar signs (HP:0002200)2.58679267
48Rectal fistula (HP:0100590)2.58013102
49Rectovaginal fistula (HP:0000143)2.58013102
50Absent thumb (HP:0009777)2.54987772
51Short hallux (HP:0010109)2.54433161
52Ectopic kidney (HP:0000086)2.49927972
53Aplasia/Hypoplasia of the sternum (HP:0006714)2.46433878
54Aplasia/Hypoplasia of the patella (HP:0006498)2.45993564
55Chronic bronchitis (HP:0004469)2.45667361
56Stenosis of the external auditory canal (HP:0000402)2.44831291
57Biliary tract neoplasm (HP:0100574)2.43968889
58Partial duplication of the phalanx of hand (HP:0009999)2.43160616
59Duplication of thumb phalanx (HP:0009942)2.41875983
60Meckel diverticulum (HP:0002245)2.41546338
61High anterior hairline (HP:0009890)2.40656931
62Aplasia/Hypoplasia of the hallux (HP:0008362)2.40277817
63Intestinal fistula (HP:0100819)2.39374384
64Supernumerary ribs (HP:0005815)2.38813746
65Supernumerary bones of the axial skeleton (HP:0009144)2.33451890
66Abnormality of chromosome stability (HP:0003220)2.33266682
67Abnormality of the ileum (HP:0001549)2.32143644
68Shawl scrotum (HP:0000049)2.30929486
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.30414403
70Neoplasm of the adrenal cortex (HP:0100641)2.29999078
71Multiple enchondromatosis (HP:0005701)2.29755587
72Anal stenosis (HP:0002025)2.29480141
73Facial cleft (HP:0002006)2.28775426
74Aqueductal stenosis (HP:0002410)2.28121402
75Increased nuchal translucency (HP:0010880)2.26704466
76Myelomeningocele (HP:0002475)2.26367409
77Hyperglycinemia (HP:0002154)2.25864939
78Skull defect (HP:0001362)2.25831380
79Absent eyebrow (HP:0002223)2.25705047
80Preaxial foot polydactyly (HP:0001841)2.25346374
81Fused cervical vertebrae (HP:0002949)2.23164617
82Facial hemangioma (HP:0000329)2.22939618
83Turricephaly (HP:0000262)2.20153151
84Bifid tongue (HP:0010297)2.19038432
85Hypoglycemic seizures (HP:0002173)2.17101452
86Vertebral fusion (HP:0002948)2.15070822
87Basal cell carcinoma (HP:0002671)2.13772215
88Gastrointestinal carcinoma (HP:0002672)2.12823140
89Malignant gastrointestinal tract tumors (HP:0006749)2.12823140
90Breast aplasia (HP:0100783)2.11598403
91Cutaneous syndactyly (HP:0012725)2.10926319
92Atresia of the external auditory canal (HP:0000413)2.10873199
93Abnormality of homocysteine metabolism (HP:0010919)2.09260303
94Homocystinuria (HP:0002156)2.09260303
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.08952556
96Short 1st metacarpal (HP:0010034)2.08952556
97Gastrointestinal atresia (HP:0002589)2.08902687
98Vaginal fistula (HP:0004320)2.08658497
99Short 4th metacarpal (HP:0010044)2.08576998
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08576998
101Hyperglycinuria (HP:0003108)2.08097727
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06789829
103Hemivertebrae (HP:0002937)2.06224957
104Horseshoe kidney (HP:0000085)2.05697940
105Abnormality of the salivary glands (HP:0010286)2.05646965
106Abnormality of the lacrimal duct (HP:0011481)2.05018464
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03621260
108Intestinal atresia (HP:0011100)2.02269440
109Neoplasm of the pancreas (HP:0002894)2.02200358
110Coronal craniosynostosis (HP:0004440)2.01618811
111Tracheoesophageal fistula (HP:0002575)2.01400878
112Bronchomalacia (HP:0002780)2.00548445
113Renal duplication (HP:0000075)1.99107389
114Broad thumb (HP:0011304)1.98874445
115Short phalanx of the thumb (HP:0009660)1.97548043
116Degeneration of anterior horn cells (HP:0002398)1.97260327
117Abnormality of the anterior horn cell (HP:0006802)1.97260327
118Duodenal stenosis (HP:0100867)1.96580900
119Small intestinal stenosis (HP:0012848)1.96580900
120Broad phalanges of the hand (HP:0009768)1.94807188
121Optic nerve hypoplasia (HP:0000609)1.94357867
122Trigonocephaly (HP:0000243)1.93720751
123Abnormality of the duodenum (HP:0002246)1.93715324
124Abnormality of the preputium (HP:0100587)1.93705900
125Pancreatic islet-cell hyperplasia (HP:0004510)1.92229431
126Asplenia (HP:0001746)1.91351955
127Neoplasm of the colon (HP:0100273)1.90930739
128Aplasia/Hypoplasia of the breasts (HP:0010311)1.90786477
129Short thumb (HP:0009778)1.90740629
130Omphalocele (HP:0001539)1.90456393
131Ovarian neoplasm (HP:0100615)1.90377426
132Oral leukoplakia (HP:0002745)1.90315917
133Vitreoretinal degeneration (HP:0000655)1.90141321
134Triphalangeal thumb (HP:0001199)1.90022442
135Nephroblastoma (Wilms tumor) (HP:0002667)1.88104077
136Anophthalmia (HP:0000528)1.88021482
137Broad metatarsal (HP:0001783)1.87821418
138Broad finger (HP:0001500)1.87813166
139Cafe-au-lait spot (HP:0000957)1.86926782
140Aplasia involving bones of the upper limbs (HP:0009823)1.86815215
141Aplasia of the phalanges of the hand (HP:0009802)1.86815215
142Aplasia involving bones of the extremities (HP:0009825)1.86815215
143Abnormality of the middle phalanges of the toes (HP:0010183)1.85771172
144Volvulus (HP:0002580)1.84892331
145Sandal gap (HP:0001852)1.84260355
146Amaurosis fugax (HP:0100576)1.84211498
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.83942960
148Absent eyelashes (HP:0000561)1.83564920
149Embryonal neoplasm (HP:0002898)1.83486878
150Humeroradial synostosis (HP:0003041)1.82832775
151Synostosis involving the elbow (HP:0003938)1.82832775
152Uterine neoplasm (HP:0010784)1.82495048
153Abnormality of the 1st metacarpal (HP:0010009)1.82002943
154Abnormality of the lower motor neuron (HP:0002366)1.80582744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.59405437
2CDK124.09003760
3WEE13.35551464
4BUB13.29697543
5TAF13.04807550
6VRK22.93342360
7TSSK62.85309474
8TTK2.80856333
9NEK22.64958277
10EPHA22.54559494
11NEK12.53519686
12SRPK12.41781194
13CDK192.24771526
14RPS6KB22.18909787
15SMG12.12983437
16LATS22.09541964
17MKNK12.08748947
18TNIK2.03979314
19EEF2K1.99557858
20PASK1.98939118
21CDK71.89247235
22FGFR21.88670733
23PLK11.86510074
24LATS11.84235183
25PLK31.82731848
26PNCK1.82361892
27BRD41.77184648
28STK38L1.64168603
29DYRK21.63772233
30ALK1.59414550
31CHEK21.57579868
32ATR1.54289428
33CHEK11.54236413
34CDK41.54132250
35MKNK21.52405816
36MAP3K81.47637248
37MAP3K101.43193488
38AURKB1.42328668
39PLK41.35723027
40CAMK1G1.30378514
41EIF2AK11.30255067
42ACVR1B1.29710849
43TLK11.28685717
44PAK41.24923417
45STK241.22249147
46AURKA1.19439163
47ATM1.16691152
48ICK1.15645959
49SCYL21.14945098
50STK101.14818060
51CDK21.11011119
52CDK61.05736240
53FLT31.03278465
54NUAK11.02484900
55MTOR1.02376175
56TGFBR11.01471030
57BRSK20.98744839
58TESK20.92398214
59STK30.91693839
60FGFR10.91586830
61DYRK30.89953305
62STK40.89634289
63NLK0.89249614
64AKT30.88826031
65VRK10.84670397
66MELK0.84309490
67CDK10.81993521
68PKN20.80680837
69MET0.79150712
70CSNK1G10.78275838
71CSNK1E0.78065043
72CASK0.74979220
73CSNK1D0.74290414
74AKT20.72824381
75CSNK2A20.68995356
76PIM10.68933958
77PRKCI0.65936678
78FGFR40.65157440
79NME10.63860054
80EIF2AK20.62407821
81EIF2AK30.60817887
82ERBB40.60728466
83TYRO30.60554732
84MAP3K40.59975092
85STK160.59466020
86PRKDC0.58091370
87PAK10.56757265
88TIE10.56230071
89BCR0.55733832
90KDR0.55725805
91MST40.55544201
92DMPK0.55003005
93KSR10.54430126
94ZAK0.54339398
95DYRK1A0.50336079
96OXSR10.50046870
97BRSK10.49577271
98PDGFRA0.48055402
99KSR20.48002965
100CSNK2A10.47842139
101BMX0.47717810
102PAK20.46905736
103MAPK140.46325157
104RPS6KA40.45735816
105CSNK1G20.44133174
106CAMK1D0.43168743
107TTN0.41970296
108NTRK10.41775075
109EGFR0.40674398
110AKT10.40059644
111BRAF0.40016280
112GSK3B0.38471026
113PBK0.36045357
114TRIM280.36005422
115MAPK10.35625777
116GRK60.35178162
117CDK11A0.34391061
118MAP3K90.34241598
119WNK30.34094194
120CDK150.32992627
121CDK180.32342896
122FGR0.32192175
123YES10.31870187
124MAP2K30.31622887
125CSNK1G30.31527980
126EPHA40.30617881
127MAPK100.29409019
128RPS6KA10.29108448
129PRKD30.28747508
130PDK40.28010488
131PDK30.28010488
132PTK20.25267501
133CLK10.24910806
134CDK90.24771754
135RPS6KA50.24571335

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.37276266
2DNA replication_Homo sapiens_hsa030304.30135049
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.02401010
4RNA transport_Homo sapiens_hsa030133.72063066
5Spliceosome_Homo sapiens_hsa030403.60229510
6One carbon pool by folate_Homo sapiens_hsa006703.44133105
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.93936823
8Cell cycle_Homo sapiens_hsa041102.88520837
9Nucleotide excision repair_Homo sapiens_hsa034202.75801435
10Homologous recombination_Homo sapiens_hsa034402.63378766
11Base excision repair_Homo sapiens_hsa034102.57396158
12RNA polymerase_Homo sapiens_hsa030202.55567111
13mRNA surveillance pathway_Homo sapiens_hsa030152.54287633
14Fanconi anemia pathway_Homo sapiens_hsa034602.14148550
15RNA degradation_Homo sapiens_hsa030182.07713228
16Ribosome_Homo sapiens_hsa030102.02132620
17Basal transcription factors_Homo sapiens_hsa030221.90236795
18Non-homologous end-joining_Homo sapiens_hsa034501.80435423
19Basal cell carcinoma_Homo sapiens_hsa052171.75865255
20Pyrimidine metabolism_Homo sapiens_hsa002401.71244482
21Proteasome_Homo sapiens_hsa030501.64178221
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64006029
23Systemic lupus erythematosus_Homo sapiens_hsa053221.63947357
24Hippo signaling pathway_Homo sapiens_hsa043901.58734152
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48672786
26p53 signaling pathway_Homo sapiens_hsa041151.45381858
27Oocyte meiosis_Homo sapiens_hsa041141.40485087
28Biosynthesis of amino acids_Homo sapiens_hsa012301.30906444
29Hedgehog signaling pathway_Homo sapiens_hsa043401.29723856
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29092215
31MicroRNAs in cancer_Homo sapiens_hsa052061.18446480
32Pyruvate metabolism_Homo sapiens_hsa006201.15135857
33Viral carcinogenesis_Homo sapiens_hsa052031.14277821
34Selenocompound metabolism_Homo sapiens_hsa004501.11056646
35Adherens junction_Homo sapiens_hsa045201.08020640
36Steroid biosynthesis_Homo sapiens_hsa001001.07500871
37TGF-beta signaling pathway_Homo sapiens_hsa043501.06195487
38Thyroid cancer_Homo sapiens_hsa052161.00994009
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.98436824
40Epstein-Barr virus infection_Homo sapiens_hsa051690.93013146
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92065079
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.91054220
43Tight junction_Homo sapiens_hsa045300.88215303
44Notch signaling pathway_Homo sapiens_hsa043300.87368803
45Purine metabolism_Homo sapiens_hsa002300.86474085
46HTLV-I infection_Homo sapiens_hsa051660.83253680
47Alcoholism_Homo sapiens_hsa050340.79208150
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76753487
49mTOR signaling pathway_Homo sapiens_hsa041500.76688708
50Lysine degradation_Homo sapiens_hsa003100.76295407
51Wnt signaling pathway_Homo sapiens_hsa043100.75684437
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.74893311
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74202336
54Huntingtons disease_Homo sapiens_hsa050160.72905396
55Colorectal cancer_Homo sapiens_hsa052100.70024069
56Protein export_Homo sapiens_hsa030600.69299132
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68830553
58Vitamin digestion and absorption_Homo sapiens_hsa049770.67541924
59Antigen processing and presentation_Homo sapiens_hsa046120.64555659
60Herpes simplex infection_Homo sapiens_hsa051680.64521662
61Bladder cancer_Homo sapiens_hsa052190.63635832
62Carbon metabolism_Homo sapiens_hsa012000.62791806
63Small cell lung cancer_Homo sapiens_hsa052220.61617616
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60398822
65Propanoate metabolism_Homo sapiens_hsa006400.60156894
66Pathways in cancer_Homo sapiens_hsa052000.57600118
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57569451
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56822235
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55892660
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55607945
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54329994
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50080195
73Pentose phosphate pathway_Homo sapiens_hsa000300.48686773
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47552134
75Parkinsons disease_Homo sapiens_hsa050120.46021323
76Proteoglycans in cancer_Homo sapiens_hsa052050.44011894
77HIF-1 signaling pathway_Homo sapiens_hsa040660.42889566
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.42324959
79Fructose and mannose metabolism_Homo sapiens_hsa000510.41729969
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39775697
81Axon guidance_Homo sapiens_hsa043600.38741445
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36358514
83Prostate cancer_Homo sapiens_hsa052150.35697630
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35632418
85Endometrial cancer_Homo sapiens_hsa052130.35087605
86Arginine biosynthesis_Homo sapiens_hsa002200.35055313
87Melanoma_Homo sapiens_hsa052180.34759030
88Metabolic pathways_Homo sapiens_hsa011000.32873102
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32846905
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31667628
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30745362
92Melanogenesis_Homo sapiens_hsa049160.28617696
93Cardiac muscle contraction_Homo sapiens_hsa042600.28451243
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27848565
95Fatty acid elongation_Homo sapiens_hsa000620.27003613
96Legionellosis_Homo sapiens_hsa051340.26984266
97Vitamin B6 metabolism_Homo sapiens_hsa007500.26596835
98Chronic myeloid leukemia_Homo sapiens_hsa052200.23036115
99Viral myocarditis_Homo sapiens_hsa054160.22797934
100Folate biosynthesis_Homo sapiens_hsa007900.22542219
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22321152
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22290862
103Oxidative phosphorylation_Homo sapiens_hsa001900.22120743
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20402902
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19616037
106Arginine and proline metabolism_Homo sapiens_hsa003300.19105630
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18672791
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18065368
109Glutathione metabolism_Homo sapiens_hsa004800.18014839
110Renal cell carcinoma_Homo sapiens_hsa052110.16932077
111FoxO signaling pathway_Homo sapiens_hsa040680.15808935
112Fatty acid metabolism_Homo sapiens_hsa012120.15621731
113Renin-angiotensin system_Homo sapiens_hsa046140.15515132
114Apoptosis_Homo sapiens_hsa042100.15288336
115Galactose metabolism_Homo sapiens_hsa000520.14783688
116Glucagon signaling pathway_Homo sapiens_hsa049220.14676455
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13885482
118AMPK signaling pathway_Homo sapiens_hsa041520.13387814
119Non-small cell lung cancer_Homo sapiens_hsa052230.12972929
120Rap1 signaling pathway_Homo sapiens_hsa040150.10149087
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07956286
122Prion diseases_Homo sapiens_hsa050200.05932748
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.03946780
124Focal adhesion_Homo sapiens_hsa045100.03909636
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.02799702

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »