LIN37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein expressed in the eye. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.73986838
2ribosomal small subunit assembly (GO:0000028)5.04015132
3proteasome assembly (GO:0043248)4.84198619
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.48942818
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.28125359
6regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.20615399
7chaperone mediated protein folding requiring cofactor (GO:0051085)4.20023276
8DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.19899197
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.18830412
10formation of translation preinitiation complex (GO:0001731)4.15758556
11intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.11001629
12signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.11001629
13signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.10912659
14signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.10912659
15signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.10912659
16cullin deneddylation (GO:0010388)4.08521048
17negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07261108
18negative regulation of ligase activity (GO:0051352)4.07261108
19maturation of SSU-rRNA (GO:0030490)4.05766892
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.02890448
21protein deneddylation (GO:0000338)4.02503739
22signal transduction involved in DNA integrity checkpoint (GO:0072401)3.98591047
23signal transduction involved in DNA damage checkpoint (GO:0072422)3.98591047
24regulation of cellular amino acid metabolic process (GO:0006521)3.94865583
25signal transduction involved in cell cycle checkpoint (GO:0072395)3.94836018
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.92381434
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.91390582
28rRNA modification (GO:0000154)3.90733389
29regulation of mitochondrial translation (GO:0070129)3.80903520
30viral transcription (GO:0019083)3.74175475
31ribosomal small subunit biogenesis (GO:0042274)3.73962320
32telomere maintenance via semi-conservative replication (GO:0032201)3.73739749
33antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.72281569
34termination of RNA polymerase III transcription (GO:0006386)3.71016031
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.71016031
367-methylguanosine mRNA capping (GO:0006370)3.70236469
37positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.69716555
38DNA strand elongation involved in DNA replication (GO:0006271)3.68094026
39translational termination (GO:0006415)3.64944178
40RNA capping (GO:0036260)3.61481860
417-methylguanosine RNA capping (GO:0009452)3.61481860
42mannosylation (GO:0097502)3.58557733
43positive regulation of ligase activity (GO:0051351)3.50661966
44telomere maintenance via recombination (GO:0000722)3.49720408
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.49220579
46DNA strand elongation (GO:0022616)3.48393728
47negative regulation of myeloid cell apoptotic process (GO:0033033)3.46633234
48translational elongation (GO:0006414)3.45529638
49ubiquinone biosynthetic process (GO:0006744)3.44513809
50translation (GO:0006412)3.44191291
51cotranslational protein targeting to membrane (GO:0006613)3.41285224
52purine nucleobase biosynthetic process (GO:0009113)3.37637310
53metallo-sulfur cluster assembly (GO:0031163)3.36219652
54iron-sulfur cluster assembly (GO:0016226)3.36219652
55protein targeting to ER (GO:0045047)3.36044063
56oxidative phosphorylation (GO:0006119)3.35590932
57translational initiation (GO:0006413)3.35308620
58transcription-coupled nucleotide-excision repair (GO:0006283)3.34713518
59neutrophil mediated immunity (GO:0002446)3.34555480
60DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.31767657
61ribonucleoprotein complex biogenesis (GO:0022613)3.31679390
62positive regulation of cell cycle arrest (GO:0071158)3.31154489
63sequestering of actin monomers (GO:0042989)3.30789430
64nucleobase biosynthetic process (GO:0046112)3.28858421
65protein localization to endoplasmic reticulum (GO:0070972)3.28225817
66ribosome biogenesis (GO:0042254)3.24884100
67protein insertion into membrane (GO:0051205)3.24773212
68ribosomal large subunit biogenesis (GO:0042273)3.24556492
69positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.24120604
70regulation of ubiquitin-protein transferase activity (GO:0051438)3.23613451
71amino acid salvage (GO:0043102)3.23332007
72L-methionine salvage (GO:0071267)3.23332007
73L-methionine biosynthetic process (GO:0071265)3.23332007
74pseudouridine synthesis (GO:0001522)3.22404485
75GPI anchor biosynthetic process (GO:0006506)3.19638256
76maturation of 5.8S rRNA (GO:0000460)3.17691683
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15615373
78rRNA methylation (GO:0031167)3.12143645
79spliceosomal snRNP assembly (GO:0000387)3.11055511
80rRNA processing (GO:0006364)3.10783101
81cellular response to interferon-beta (GO:0035458)3.10356037
82cellular protein complex disassembly (GO:0043624)3.09712430
83tRNA methylation (GO:0030488)3.09635486
84regulation of ligase activity (GO:0051340)3.09609701
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09339989
86ubiquinone metabolic process (GO:0006743)3.08693099
87viral mRNA export from host cell nucleus (GO:0046784)3.07665864
88regulation of synapse structural plasticity (GO:0051823)3.07292146
89chaperone-mediated protein transport (GO:0072321)3.07185272
90mitotic recombination (GO:0006312)3.06320283
91protein targeting to mitochondrion (GO:0006626)3.04983478
92response to peptidoglycan (GO:0032494)3.03882324
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03399788
94cellular component biogenesis (GO:0044085)3.01825232
95viral life cycle (GO:0019058)3.01820113
96establishment of protein localization to mitochondrion (GO:0072655)3.01719099
97peptidyl-histidine modification (GO:0018202)3.01274507
98neutrophil activation involved in immune response (GO:0002283)3.00575714
99G1/S transition of mitotic cell cycle (GO:0000082)3.00356007
100cell cycle G1/S phase transition (GO:0044843)3.00356007
101cellular response to nicotine (GO:0071316)2.99851898
102positive regulation of mitochondrial fission (GO:0090141)2.99725887
103rRNA metabolic process (GO:0016072)2.99385678
104establishment of mitochondrion localization (GO:0051654)2.97361122
105DNA replication checkpoint (GO:0000076)2.95950159
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95767001
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95618084
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.95618084
109NADH dehydrogenase complex assembly (GO:0010257)2.95618084
110antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.92958596
111GDP-mannose metabolic process (GO:0019673)2.92398456
112C-terminal protein lipidation (GO:0006501)2.92312217
113response to interferon-beta (GO:0035456)2.92140621
114signal transduction in response to DNA damage (GO:0042770)2.91355420
115negative regulation of B cell apoptotic process (GO:0002903)2.91283440
116immunoglobulin mediated immune response (GO:0016064)2.90840074
117protein complex biogenesis (GO:0070271)2.90660467
118regulation of cilium movement (GO:0003352)2.89772211
119ATP synthesis coupled proton transport (GO:0015986)2.89620493
120energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89620493
121negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.88456987
122negative regulation of cell cycle G1/S phase transition (GO:1902807)2.88456987
123establishment of protein localization to mitochondrial membrane (GO:0090151)2.87633659
124platelet dense granule organization (GO:0060155)2.87560985
125telomere maintenance via telomere lengthening (GO:0010833)2.85702412
126GPI anchor metabolic process (GO:0006505)2.85144304
127energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82545962
128ATP hydrolysis coupled proton transport (GO:0015991)2.82545962
129leukocyte degranulation (GO:0043299)2.79786544
130granulocyte activation (GO:0036230)2.79666729
131preassembly of GPI anchor in ER membrane (GO:0016254)2.73583474
132galactose catabolic process (GO:0019388)2.73448957
133regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.71465310
134negative regulation of interleukin-12 production (GO:0032695)2.70150847
135positive regulation of TOR signaling (GO:0032008)2.62756471
136quinone biosynthetic process (GO:1901663)2.62316734
137mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61617289
138neutrophil activation (GO:0042119)2.61411198
139phosphatidylglycerol biosynthetic process (GO:0006655)2.59805870
140regulation of chemokine biosynthetic process (GO:0045073)2.59225474
141purine nucleotide salvage (GO:0032261)2.55464325
142myeloid leukocyte mediated immunity (GO:0002444)2.54769118
143regulation of B cell apoptotic process (GO:0002902)2.54016011
144phagosome maturation (GO:0090382)2.48989700
145C-terminal protein amino acid modification (GO:0018410)2.46379266
146negative regulation of glial cell proliferation (GO:0060253)2.46141718
147positive regulation of protein homooligomerization (GO:0032464)2.45744283
148response to misfolded protein (GO:0051788)2.45394053
149myeloid cell activation involved in immune response (GO:0002275)2.44734725
150pyrimidine nucleobase catabolic process (GO:0006208)2.44005526
151protein maturation by protein folding (GO:0022417)2.43667594
152mitochondrion transport along microtubule (GO:0047497)2.43632545
153establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43632545
154modulation by symbiont of host immune response (GO:0052553)2.42567646
155positive regulation by symbiont of host defense response (GO:0052509)2.42567646
156modulation by symbiont of host defense response (GO:0052031)2.42567646
157modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42567646
158modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42567646
159positive regulation by organism of defense response of other organism involved in symbiotic interact2.42567646
160mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42481060
161viral protein processing (GO:0019082)2.41702813
162mitochondrial respiratory chain complex assembly (GO:0033108)2.40342651
163negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39565576
164negative regulation of cell killing (GO:0031342)2.39565576
165negative regulation of mast cell activation (GO:0033004)2.39532429
166regulation of release of cytochrome c from mitochondria (GO:0090199)2.38515651
167respiratory electron transport chain (GO:0022904)2.37300938
168type I interferon signaling pathway (GO:0060337)2.37299485
169cellular response to type I interferon (GO:0071357)2.37299485
170cellular response to arsenic-containing substance (GO:0071243)2.36592565
171amino sugar catabolic process (GO:0046348)2.36440486
172macrophage activation involved in immune response (GO:0002281)2.35735016
173tumor necrosis factor-mediated signaling pathway (GO:0033209)2.35080010
174positive regulation of amino acid transport (GO:0051957)2.34679014
175disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.33421107
176killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.33421107
177electron transport chain (GO:0022900)2.33097598
178positive regulation of monocyte chemotaxis (GO:0090026)2.32044157
179protoporphyrinogen IX metabolic process (GO:0046501)2.32017703
180regulation of protein kinase A signaling (GO:0010738)2.31710504
181negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31047932
182regulation of autophagic vacuole assembly (GO:2000785)2.30262030
183regulation of interferon-beta biosynthetic process (GO:0045357)2.30163398
184response to type I interferon (GO:0034340)2.29751140
185positive regulation of lymphocyte apoptotic process (GO:0070230)2.29489339
186germinal center formation (GO:0002467)2.28731603
187tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.28626135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.03092062
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.58913346
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.07951613
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00281844
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81455408
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80834409
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.76925178
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.63566564
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.60510569
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.57671659
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09203206
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05764152
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87808976
14VDR_23849224_ChIP-Seq_CD4+_Human2.67652583
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64604193
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53207303
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.50337891
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45328248
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40498485
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40085017
21XRN2_22483619_ChIP-Seq_HELA_Human2.34655240
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34359702
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34357924
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31419174
25GABP_19822575_ChIP-Seq_HepG2_Human2.27428282
26* SRF_21415370_ChIP-Seq_HL-1_Mouse2.25419264
27FOXP3_21729870_ChIP-Seq_TREG_Human2.22210583
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21660625
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17676741
30DCP1A_22483619_ChIP-Seq_HELA_Human2.17533471
31ELF1_20517297_ChIP-Seq_JURKAT_Human2.15101274
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.14577168
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11687440
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09252917
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04947748
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98712789
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93100571
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.92760169
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90131714
40BCL6_27268052_Chip-Seq_Bcells_Human1.88518768
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87830540
42CIITA_25753668_ChIP-Seq_RAJI_Human1.87640560
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85901502
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82910290
45TTF2_22483619_ChIP-Seq_HELA_Human1.77058470
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74012086
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73837612
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72625939
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68070599
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67708053
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66748466
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65691376
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60015600
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59671685
55ELK1_19687146_ChIP-ChIP_HELA_Human1.57949736
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57223801
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56166613
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54785478
59BCOR_27268052_Chip-Seq_Bcells_Human1.54625314
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.54518243
61P68_20966046_ChIP-Seq_HELA_Human1.50868340
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50284664
63PHF8_20622854_ChIP-Seq_HELA_Human1.47173022
64E2F1_20622854_ChIP-Seq_HELA_Human1.46828046
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45336996
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44110028
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41691948
68* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40081212
69UTX_26944678_Chip-Seq_JUKART_Human1.39024491
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.38469761
71KDM5A_27292631_Chip-Seq_BREAST_Human1.37790927
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35683972
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35182643
74LXR_22292898_ChIP-Seq_THP-1_Human1.34874560
75CTCF_20526341_ChIP-Seq_ESCs_Human1.31920687
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31376385
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31222066
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30866157
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30261343
80SPI1_23547873_ChIP-Seq_NB4_Human1.28174736
81MYC_22102868_ChIP-Seq_BL_Human1.27312367
82MAF_26560356_Chip-Seq_TH1_Human1.25604062
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.24798467
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24135697
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23720715
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.22995978
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22671611
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22407430
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22126869
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.20477741
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19336515
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18363908
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18163297
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.17752100
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17019089
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.16497197
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16388820
98ZNF274_21170338_ChIP-Seq_K562_Hela1.16061269
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15405105
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.12565574
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.10932320
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09034338
103P300_27268052_Chip-Seq_Bcells_Human1.07564662
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07421236
105TFEB_21752829_ChIP-Seq_HELA_Human1.07387118
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07356346
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07108207
108CTCF_21964334_Chip-Seq_Bcells_Human1.06685892
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05331589
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.05227052
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04434291
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04392569
113E2F1_21310950_ChIP-Seq_MCF-7_Human1.04139029
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02624087
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02519819
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02216187
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01631417
118MYC_18940864_ChIP-ChIP_HL60_Human1.01612325
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99730029
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99390088
121STAT1_20625510_ChIP-Seq_HELA_Human0.99154583
122SA1_27219007_Chip-Seq_Bcells_Human0.98941795
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.98450129
124IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97608933
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97062970
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96755629
127VDR_21846776_ChIP-Seq_THP-1_Human0.96022676
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94995958
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94757886
130CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89883125
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89369800
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86894496
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86369150
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85869885
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84401007
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83819923
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83570958
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83092733
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83061755
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82461076
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80827568
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79826927
143MAF_26560356_Chip-Seq_TH2_Human0.79622370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.56868220
2MP0004957_abnormal_blastocyst_morpholog3.88333280
3MP0003077_abnormal_cell_cycle3.31693707
4MP0003111_abnormal_nucleus_morphology3.25531787
5MP0010094_abnormal_chromosome_stability3.12347409
6MP0003724_increased_susceptibility_to3.09550616
7MP0009840_abnormal_foam_cell2.83468234
8MP0008058_abnormal_DNA_repair2.74951441
9MP0005671_abnormal_response_to2.69351543
10MP0006292_abnormal_olfactory_placode2.63972794
11MP0008057_abnormal_DNA_replication2.57616688
12MP0001835_abnormal_antigen_presentation2.54453075
13MP0002653_abnormal_ependyma_morphology2.50869463
14MP0008007_abnormal_cellular_replicative2.40697646
15MP0008932_abnormal_embryonic_tissue2.27524230
16MP0003763_abnormal_thymus_physiology2.25976758
17MP0008877_abnormal_DNA_methylation2.22723312
18MP0003123_paternal_imprinting2.19883612
19MP0003303_peritoneal_inflammation2.17969962
20MP0002396_abnormal_hematopoietic_system2.11583626
21MP0003191_abnormal_cellular_cholesterol2.11451714
22MP0008260_abnormal_autophagy2.10569767
23MP0009333_abnormal_splenocyte_physiolog2.05809547
24MP0005360_urolithiasis2.02542967
25MP0009764_decreased_sensitivity_to2.01671789
26MP0006082_CNS_inflammation1.97479104
27MP0003718_maternal_effect1.97050639
28MP0002822_catalepsy1.95774742
29MP0003786_premature_aging1.91593472
30MP0005397_hematopoietic_system_phenotyp1.88268847
31MP0001545_abnormal_hematopoietic_system1.88268847
32MP0004147_increased_porphyrin_level1.84786990
33MP0006036_abnormal_mitochondrial_physio1.82938964
34MP0002398_abnormal_bone_marrow1.77686009
35MP0005075_abnormal_melanosome_morpholog1.76324262
36MP0003186_abnormal_redox_activity1.75655740
37MP0009785_altered_susceptibility_to1.73660855
38MP0000685_abnormal_immune_system1.72354129
39MP0009278_abnormal_bone_marrow1.70217206
40MP0006035_abnormal_mitochondrial_morpho1.70146891
41MP0004859_abnormal_synaptic_plasticity1.68766885
42MP0001986_abnormal_taste_sensitivity1.63187670
43MP0000358_abnormal_cell_content/1.60147646
44MP0000689_abnormal_spleen_morphology1.58387724
45MP0001800_abnormal_humoral_immune1.56949501
46MP0002722_abnormal_immune_system1.55101281
47MP0002132_abnormal_respiratory_system1.52015544
48MP0001968_abnormal_touch/_nociception1.50612626
49MP0005451_abnormal_body_composition1.50310474
50MP0002420_abnormal_adaptive_immunity1.48919099
51MP0001819_abnormal_immune_cell1.47281643
52MP0009697_abnormal_copulation1.46609507
53MP0003656_abnormal_erythrocyte_physiolo1.44082815
54MP0004808_abnormal_hematopoietic_stem1.43617462
55MP0000716_abnormal_immune_system1.43363977
56MP0000703_abnormal_thymus_morphology1.42614230
57MP0000604_amyloidosis1.40751014
58MP0002429_abnormal_blood_cell1.38107924
59MP0002452_abnormal_antigen_presenting1.38055537
60MP0002723_abnormal_immune_serum1.37020459
61MP0008469_abnormal_protein_level1.36521039
62MP0001764_abnormal_homeostasis1.36506182
63MP0000313_abnormal_cell_death1.35749844
64MP0000490_abnormal_crypts_of1.34949799
65MP0004510_myositis1.34121514
66MP0010386_abnormal_urinary_bladder1.33726248
67MP0002160_abnormal_reproductive_system1.32581047
68MP0000343_altered_response_to1.31184041
69MP0002019_abnormal_tumor_incidence1.30250568
70MP0003329_amyloid_beta_deposits1.27514890
71MP0000750_abnormal_muscle_regeneration1.27150599
72MP0002735_abnormal_chemical_nociception1.26003409
73MP0000015_abnormal_ear_pigmentation1.21266014
74MP0009379_abnormal_foot_pigmentation1.20096864
75MP0003866_abnormal_defecation1.19514595
76MP0000350_abnormal_cell_proliferation1.19040235
77MP0006276_abnormal_autonomic_nervous1.18763747
78MP0001529_abnormal_vocalization1.18506097
79MP0002095_abnormal_skin_pigmentation1.17795446
80MP0005025_abnormal_response_to1.17750489
81MP0005000_abnormal_immune_tolerance1.17632944
82MP0002148_abnormal_hypersensitivity_rea1.17359603
83MP0005389_reproductive_system_phenotype1.17291439
84MP0001533_abnormal_skeleton_physiology1.16359688
85MP0001730_embryonic_growth_arrest1.14195135
86MP0000858_altered_metastatic_potential1.13863795
87MP0003121_genomic_imprinting1.12586735
88MP0000372_irregular_coat_pigmentation1.11507873
89MP0003879_abnormal_hair_cell1.10104657
90MP0001905_abnormal_dopamine_level1.09814707
91MP0001853_heart_inflammation1.09461510
92MP0002733_abnormal_thermal_nociception1.08875720
93MP0008874_decreased_physiological_sensi1.08335271
94MP0004142_abnormal_muscle_tone1.07051599
95MP0000465_gastrointestinal_hemorrhage1.05563640
96MP0005646_abnormal_pituitary_gland1.05259879
97MP0009046_muscle_twitch1.03399615
98MP0002405_respiratory_system_inflammati1.01538482
99MP0001919_abnormal_reproductive_system0.98861515
100MP0005410_abnormal_fertilization0.98653318
101MP0001970_abnormal_pain_threshold0.97816768
102MP0003075_altered_response_to0.97042107
103MP0002210_abnormal_sex_determination0.96512372
104MP0002332_abnormal_exercise_endurance0.95860965
105MP0000538_abnormal_urinary_bladder0.93588221
106MP0009765_abnormal_xenobiotic_induced0.93058216
107MP0005310_abnormal_salivary_gland0.92497602
108MP0003635_abnormal_synaptic_transmissio0.91191683
109MP0002163_abnormal_gland_morphology0.91135438
110MP0002063_abnormal_learning/memory/cond0.91014367
111MP0000681_abnormal_thyroid_gland0.90357642
112MP0003787_abnormal_imprinting0.89358812
113MP0004133_heterotaxia0.89342342
114MP0002277_abnormal_respiratory_mucosa0.89206952
115MP0005387_immune_system_phenotype0.89049663
116MP0001790_abnormal_immune_system0.89049663
117MP0005464_abnormal_platelet_physiology0.88073129
118MP0002572_abnormal_emotion/affect_behav0.87714685
119MP0002419_abnormal_innate_immunity0.87112197
120MP0001697_abnormal_embryo_size0.86346517
121MP0003172_abnormal_lysosome_physiology0.86138616
122MP0002080_prenatal_lethality0.85226427
123MP0002736_abnormal_nociception_after0.84918514
124MP0003806_abnormal_nucleotide_metabolis0.84773482
125MP0001929_abnormal_gametogenesis0.84565260
126MP0001542_abnormal_bone_strength0.83670693
127MP0005084_abnormal_gallbladder_morpholo0.83553993
128MP0005384_cellular_phenotype0.82714341
129MP0001188_hyperpigmentation0.82483577
130MP0003315_abnormal_perineum_morphology0.81626085
131MP0005499_abnormal_olfactory_system0.81443204
132MP0005394_taste/olfaction_phenotype0.81443204
133MP0009763_increased_sensitivity_to0.80987195
134MP0005058_abnormal_lysosome_morphology0.79978186
135MP0009745_abnormal_behavioral_response0.79805901
136MP0008873_increased_physiological_sensi0.78828880
137MP0001845_abnormal_inflammatory_respons0.78519046
138MP0001119_abnormal_female_reproductive0.78270835
139MP0004043_abnormal_pH_regulation0.78001683
140MP0003638_abnormal_response/metabolism_0.77564348
141MP0002909_abnormal_adrenal_gland0.77516209
142MP0002064_seizures0.76857011
143MP0005174_abnormal_tail_pigmentation0.75978343
144MP0003183_abnormal_peptide_metabolism0.75969047
145MP0008789_abnormal_olfactory_epithelium0.75182841
146MP0001145_abnormal_male_reproductive0.74178198
147MP0003436_decreased_susceptibility_to0.72700052
148MP0000749_muscle_degeneration0.72507493
149MP0002006_tumorigenesis0.70370019
150MP0008872_abnormal_physiological_respon0.69995855
151MP0002166_altered_tumor_susceptibility0.68954361
152MP0000653_abnormal_sex_gland0.68517435
153MP0001873_stomach_inflammation0.65860082

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.27607272
2Hepatocellular necrosis (HP:0001404)4.14019664
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.00401979
4Abnormality of liposaccharide metabolism (HP:0010968)3.88673791
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.88673791
6Abnormality of glycolipid metabolism (HP:0010969)3.88673791
7Aplastic anemia (HP:0001915)3.85724726
8Abnormal number of erythroid precursors (HP:0012131)3.73060394
9Abnormality of cells of the erythroid lineage (HP:0012130)3.69800604
10Hepatic necrosis (HP:0002605)3.69102533
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66352761
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66352761
13Acute necrotizing encephalopathy (HP:0006965)3.60594127
14Mitochondrial inheritance (HP:0001427)3.53103717
15Abnormal mitochondria in muscle tissue (HP:0008316)3.38283415
16Increased CSF lactate (HP:0002490)3.33489051
17Vacuolated lymphocytes (HP:0001922)3.30938272
18Microretrognathia (HP:0000308)3.28435886
19Birth length less than 3rd percentile (HP:0003561)3.26297960
20Reticulocytopenia (HP:0001896)3.21538156
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17478132
22IgM deficiency (HP:0002850)3.05470688
23Type 2 muscle fiber atrophy (HP:0003554)3.00116290
24Type I transferrin isoform profile (HP:0003642)2.91995676
25Muscle fiber atrophy (HP:0100295)2.89730703
26Increased serum lactate (HP:0002151)2.87331598
27Progressive macrocephaly (HP:0004481)2.86804590
28Increased muscle lipid content (HP:0009058)2.86376819
29Stomatitis (HP:0010280)2.84331736
30Renal Fanconi syndrome (HP:0001994)2.82080163
31Increased intramyocellular lipid droplets (HP:0012240)2.76155140
32Abnormality of the anterior horn cell (HP:0006802)2.74970947
33Degeneration of anterior horn cells (HP:0002398)2.74970947
34Mutism (HP:0002300)2.74522529
35Acute encephalopathy (HP:0006846)2.74079239
36Petechiae (HP:0000967)2.73721163
37Generalized aminoaciduria (HP:0002909)2.70287164
38Polyphagia (HP:0002591)2.68491851
39Cholecystitis (HP:0001082)2.67877232
40Abnormal gallbladder physiology (HP:0012438)2.67877232
41Oral leukoplakia (HP:0002745)2.67812254
42Abnormality of macrophages (HP:0004311)2.64510393
43Severe visual impairment (HP:0001141)2.63384429
44CNS hypomyelination (HP:0003429)2.61760337
45Dysostosis multiplex (HP:0000943)2.59633421
46Mediastinal lymphadenopathy (HP:0100721)2.57516662
47Orchitis (HP:0100796)2.56013079
48Rough bone trabeculation (HP:0100670)2.55144161
49Loss of speech (HP:0002371)2.54312478
50Tongue fasciculations (HP:0001308)2.54026822
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52362019
52Microvesicular hepatic steatosis (HP:0001414)2.51714345
533-Methylglutaconic aciduria (HP:0003535)2.50890775
54Poor head control (HP:0002421)2.49061286
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48334431
56Lactic acidosis (HP:0003128)2.47588469
57Large eyes (HP:0001090)2.47290170
58IgG deficiency (HP:0004315)2.46668907
59Retrobulbar optic neuritis (HP:0100654)2.46497133
60Optic neuritis (HP:0100653)2.46497133
61Breast hypoplasia (HP:0003187)2.43839984
62Carpal bone hypoplasia (HP:0001498)2.43146773
63Premature graying of hair (HP:0002216)2.42176358
64Patent foramen ovale (HP:0001655)2.41471926
65Macrocytic anemia (HP:0001972)2.41243410
66Premature ovarian failure (HP:0008209)2.41051930
67Myositis (HP:0100614)2.40900346
68Thrombocytosis (HP:0001894)2.40558395
69Progressive microcephaly (HP:0000253)2.36808216
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.35456652
71Patellar aplasia (HP:0006443)2.33660679
72Hypothermia (HP:0002045)2.33052630
73Disinhibition (HP:0000734)2.32664562
74Respiratory failure (HP:0002878)2.32640267
75Lipid accumulation in hepatocytes (HP:0006561)2.32055724
76Pancytopenia (HP:0001876)2.29530911
77Obstructive lung disease (HP:0006536)2.28189488
78Chronic obstructive pulmonary disease (HP:0006510)2.28189488
79Emotional lability (HP:0000712)2.27935972
80Unsteady gait (HP:0002317)2.27027926
81Pallor (HP:0000980)2.25948794
82Bone marrow hypocellularity (HP:0005528)2.25187384
83Secondary amenorrhea (HP:0000869)2.24368224
84Episodic fever (HP:0001954)2.23932954
85Myelodysplasia (HP:0002863)2.23517759
86Reduced antithrombin III activity (HP:0001976)2.23394743
87Cellular immunodeficiency (HP:0005374)2.22169704
88Abnormality of the ileum (HP:0001549)2.20661372
89Elevated erythrocyte sedimentation rate (HP:0003565)2.19597194
90Aplasia/Hypoplasia of the patella (HP:0006498)2.18611768
91Abnormality of glycolysis (HP:0004366)2.18504892
92Increased serum pyruvate (HP:0003542)2.18504892
93Abnormality of the preputium (HP:0100587)2.17593653
94Absent thumb (HP:0009777)2.15531920
95Abnormality of eosinophils (HP:0001879)2.15438480
96Exertional dyspnea (HP:0002875)2.15239540
97Severe muscular hypotonia (HP:0006829)2.13867552
98Agnosia (HP:0010524)2.12350269
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11392998
100Dicarboxylic aciduria (HP:0003215)2.11392998
101B lymphocytopenia (HP:0010976)2.11136533
102Abnormality of B cell number (HP:0010975)2.11136533
103Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10730095
104Eosinophilia (HP:0001880)2.10562445
105Recurrent abscess formation (HP:0002722)2.09721615
106Muscle fibrillation (HP:0010546)2.09534683
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09185239
108Abnormal protein N-linked glycosylation (HP:0012347)2.09185239
109Abnormal protein glycosylation (HP:0012346)2.09185239
110Abnormal glycosylation (HP:0012345)2.09185239
111Exercise intolerance (HP:0003546)2.08455531
112Meckel diverticulum (HP:0002245)2.07614326
113Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07097301
114Pulmonary fibrosis (HP:0002206)2.06590087
115CNS demyelination (HP:0007305)2.06519768
116Purpura (HP:0000979)2.06332180
117Neuronal loss in central nervous system (HP:0002529)2.05910655
118Colon cancer (HP:0003003)2.03723916
119Prolonged neonatal jaundice (HP:0006579)2.03139267
120Abnormality of dental color (HP:0011073)2.00571865
121Failure to thrive in infancy (HP:0001531)1.98207919
122Increased hepatocellular lipid droplets (HP:0006565)1.98130438
123Myokymia (HP:0002411)1.96742344
124Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96510221
125Diminished motivation (HP:0000745)1.92446900
126Abnormal hair whorl (HP:0010721)1.90495340
127Lymphoma (HP:0002665)1.89528375
128Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88518327
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88150884
130Abnormality of polysaccharide metabolism (HP:0011012)1.88150884
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88150884
132Type II lissencephaly (HP:0007260)1.87875183
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87655134
134Cholelithiasis (HP:0001081)1.87201975
135Cerebral edema (HP:0002181)1.87012756
136Cortical visual impairment (HP:0100704)1.86391836
137Optic disc pallor (HP:0000543)1.86169078
138Amaurosis fugax (HP:0100576)1.85638473
139Combined immunodeficiency (HP:0005387)1.85594815
140Poor suck (HP:0002033)1.85154798
141Abnormality of fatty-acid metabolism (HP:0004359)1.84597241
142Gait imbalance (HP:0002141)1.84001385
143Recurrent bacterial skin infections (HP:0005406)1.83677480
144Severe combined immunodeficiency (HP:0004430)1.83625218
145Granulocytopenia (HP:0001913)1.82543874
146Neutropenia (HP:0001875)1.82521846
147Broad distal phalanx of finger (HP:0009836)1.82325615
148Panhypogammaglobulinemia (HP:0003139)1.81640447
149Cleft eyelid (HP:0000625)1.79945807
150Upper limb muscle weakness (HP:0003484)1.79100816
151Retinal dysplasia (HP:0007973)1.77489520
152Agitation (HP:0000713)1.76761043
153Personality changes (HP:0000751)1.76526857
154Abnormality of T cell physiology (HP:0011840)1.75121864
155Hepatosplenomegaly (HP:0001433)1.75056270
156Encephalitis (HP:0002383)1.73470139
157Poikiloderma (HP:0001029)1.73231353
158Recurrent bronchitis (HP:0002837)1.73104929
159Congenital primary aphakia (HP:0007707)1.73023690
160Delusions (HP:0000746)1.72835487
161Nephrogenic diabetes insipidus (HP:0009806)1.71974839
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.71947310
163Abnormality of T cells (HP:0002843)1.70543152
164Atrophy/Degeneration involving motor neurons (HP:0007373)1.70293932
165Abnormal trabecular bone morphology (HP:0100671)1.70156429
166Limb dystonia (HP:0002451)1.69152246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.82315841
2BUB15.37181056
3STK163.74543088
4MAP4K23.62983689
5ACVR1B3.11361142
6TESK22.83464617
7WEE12.81180115
8MAP3K122.68721760
9TSSK62.54981609
10EIF2AK12.45784313
11NME22.36762540
12PIM22.35998420
13TNK22.30310558
14MATK1.98531624
15MARK11.97787946
16MAP4K11.96064804
17PLK41.80975097
18BRSK21.74910707
19BRAF1.73379909
20NEK11.72695100
21VRK11.70625841
22IRAK31.68862795
23ARAF1.65162896
24CDK81.64551724
25SIK31.57232388
26EIF2AK31.57045021
27SRPK11.56068684
28MAPKAPK31.55750037
29SIK21.54263814
30CCNB11.53392574
31DAPK11.41379314
32NME11.40748158
33BRSK11.38064258
34TXK1.37553461
35DYRK1B1.37478221
36IRAK41.35083666
37MAP2K41.30563682
38TAOK11.29557376
39CDC71.27210781
40VRK21.26984304
41CDK191.26662625
42TESK11.25619543
43ZAK1.24181884
44PLK11.22781625
45BCKDK1.22249538
46ERN11.20170606
47BMPR1B1.19838584
48KDR1.15465592
49NEK21.15269053
50ZAP701.12279023
51MARK31.10634082
52RPS6KB21.07942269
53RIPK41.07599353
54CSNK1G31.05294488
55MYLK1.04514844
56TLK11.02996144
57AURKA0.97765040
58CDK70.97285788
59FGR0.96594717
60TGFBR10.95856088
61MAP3K50.91906303
62AURKB0.90530959
63TTK0.88438447
64PLK30.88173880
65RPS6KA40.88098783
66FES0.88037513
67KIT0.87835880
68TEC0.85798646
69CSF1R0.85450904
70ATR0.85322625
71CSNK1A1L0.83076043
72SYK0.82860992
73TAOK20.80314150
74GRK60.79742530
75MAP3K110.78800286
76PDK20.78266645
77BTK0.78193470
78AKT30.77967976
79PKN10.76450151
80MAP3K40.73715511
81EEF2K0.73650785
82DAPK20.73385780
83DYRK20.73211219
84MAP3K30.73124006
85JAK30.71433683
86CSNK1G20.71172669
87BLK0.70007235
88MAPK130.69638586
89PAK40.67601270
90STK100.67220426
91PRKD20.67200611
92MUSK0.65935714
93EPHB10.65557697
94CSNK2A10.61905672
95MAP3K10.60800935
96CHEK20.60271517
97ABL20.60124067
98GRK50.59819112
99IKBKB0.59100585
100MAP2K70.59046234
101TBK10.58683828
102DAPK30.58030240
103RPS6KA50.58021052
104MKNK10.57544944
105MST40.57303790
106PIM10.56460347
107PAK10.54571251
108MAPKAPK50.54398721
109TYK20.53157453
110CAMKK20.51263238
111CASK0.49396118
112ILK0.49046208
113CSNK2A20.48951011
114PASK0.48572108
115PRKCI0.47934360
116MAP3K80.46985623
117ADRBK20.46848050
118CSNK1G10.46384347
119IKBKE0.45241283
120GRK70.43905437
121FLT30.43772439
122RPS6KA20.43527504
123LYN0.42818168
124LIMK10.41527755
125CSK0.41348870
126LCK0.40317700
127RPS6KA60.39868284
128CDK140.39855632
129STK240.39585490
130MAP2K30.39481449
131MAP2K60.39144437
132EPHA30.38589210
133WNK30.38405983
134BMPR20.37028182
135DYRK30.36443935
136NTRK20.36384746
137RPS6KC10.36206843
138RPS6KL10.36206843
139IRAK20.36006122
140CDK11A0.35828187
141MKNK20.32676456
142DDR20.32243913
143PRKCQ0.32165893
144EIF2AK20.31782782
145MAPKAPK20.31474426
146PRKCZ0.31439707
147LRRK20.31398011
148CDK50.28548900

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.20820338
2Ribosome_Homo sapiens_hsa030104.35212012
3DNA replication_Homo sapiens_hsa030303.81063240
4RNA polymerase_Homo sapiens_hsa030203.55869980
5Mismatch repair_Homo sapiens_hsa034303.13796609
6Base excision repair_Homo sapiens_hsa034102.88975490
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85887298
8Spliceosome_Homo sapiens_hsa030402.58557737
9Pyrimidine metabolism_Homo sapiens_hsa002402.53213710
10Nucleotide excision repair_Homo sapiens_hsa034202.40220165
11Oxidative phosphorylation_Homo sapiens_hsa001902.38428413
12RNA transport_Homo sapiens_hsa030132.30567828
13Homologous recombination_Homo sapiens_hsa034402.28961553
14Parkinsons disease_Homo sapiens_hsa050122.23400274
15Protein export_Homo sapiens_hsa030602.13616574
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.92386450
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.88205641
18Basal transcription factors_Homo sapiens_hsa030221.82731383
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80184769
20Huntingtons disease_Homo sapiens_hsa050161.72552927
21Lysosome_Homo sapiens_hsa041421.71473924
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70007938
23RNA degradation_Homo sapiens_hsa030181.67325097
24Cell cycle_Homo sapiens_hsa041101.64779491
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62308632
26Non-homologous end-joining_Homo sapiens_hsa034501.60947492
27Primary immunodeficiency_Homo sapiens_hsa053401.60002964
28Nicotine addiction_Homo sapiens_hsa050331.57988167
29Tuberculosis_Homo sapiens_hsa051521.57190664
30Fanconi anemia pathway_Homo sapiens_hsa034601.49687543
31Purine metabolism_Homo sapiens_hsa002301.46738834
32Osteoclast differentiation_Homo sapiens_hsa043801.40708642
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39958081
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38723767
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36766225
36Salmonella infection_Homo sapiens_hsa051321.36050382
37Epstein-Barr virus infection_Homo sapiens_hsa051691.35263668
38Staphylococcus aureus infection_Homo sapiens_hsa051501.34368447
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29184239
40Malaria_Homo sapiens_hsa051441.27907063
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26045594
42Alzheimers disease_Homo sapiens_hsa050101.21341803
43Folate biosynthesis_Homo sapiens_hsa007901.20771114
44One carbon pool by folate_Homo sapiens_hsa006701.19990777
45Regulation of autophagy_Homo sapiens_hsa041401.18390430
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18003934
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11808337
48Collecting duct acid secretion_Homo sapiens_hsa049661.10161708
49Antigen processing and presentation_Homo sapiens_hsa046121.09970775
50p53 signaling pathway_Homo sapiens_hsa041151.01687765
51Pertussis_Homo sapiens_hsa051331.01600168
52Pentose phosphate pathway_Homo sapiens_hsa000301.00717950
53Fructose and mannose metabolism_Homo sapiens_hsa000511.00520223
54Autoimmune thyroid disease_Homo sapiens_hsa053200.96424536
55GABAergic synapse_Homo sapiens_hsa047270.86494864
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82033931
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.81420001
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.79867401
59mRNA surveillance pathway_Homo sapiens_hsa030150.79464321
60Sulfur metabolism_Homo sapiens_hsa009200.79239303
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78600630
62Herpes simplex infection_Homo sapiens_hsa051680.78387830
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78216519
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76912087
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75248607
66TNF signaling pathway_Homo sapiens_hsa046680.75068851
67Allograft rejection_Homo sapiens_hsa053300.74123062
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73239443
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.72513577
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72251581
71Peroxisome_Homo sapiens_hsa041460.72014607
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71899321
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70705883
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65738699
75Phototransduction_Homo sapiens_hsa047440.63920333
76Acute myeloid leukemia_Homo sapiens_hsa052210.61698313
77Legionellosis_Homo sapiens_hsa051340.61536088
78Vibrio cholerae infection_Homo sapiens_hsa051100.61014072
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58108784
80Morphine addiction_Homo sapiens_hsa050320.57982686
81Measles_Homo sapiens_hsa051620.57773511
82Biosynthesis of amino acids_Homo sapiens_hsa012300.57615944
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57590036
84Other glycan degradation_Homo sapiens_hsa005110.56803712
85Viral myocarditis_Homo sapiens_hsa054160.56113846
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55931488
87N-Glycan biosynthesis_Homo sapiens_hsa005100.55681489
88Type I diabetes mellitus_Homo sapiens_hsa049400.55076670
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51927021
90Synaptic vesicle cycle_Homo sapiens_hsa047210.51266705
91Galactose metabolism_Homo sapiens_hsa000520.50286524
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49420218
93Endocytosis_Homo sapiens_hsa041440.48796671
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48127008
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47699667
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46837143
97Glutathione metabolism_Homo sapiens_hsa004800.46426066
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45757420
99Shigellosis_Homo sapiens_hsa051310.45391054
100Metabolic pathways_Homo sapiens_hsa011000.45058020
101Carbon metabolism_Homo sapiens_hsa012000.44584530
102Vitamin B6 metabolism_Homo sapiens_hsa007500.43549549
103Oocyte meiosis_Homo sapiens_hsa041140.43235823
104Hematopoietic cell lineage_Homo sapiens_hsa046400.42721818
105Chemokine signaling pathway_Homo sapiens_hsa040620.42401475
106Viral carcinogenesis_Homo sapiens_hsa052030.41866511
107Hepatitis C_Homo sapiens_hsa051600.41485577
108Rheumatoid arthritis_Homo sapiens_hsa053230.39488246
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38471075
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.37752422
111Sulfur relay system_Homo sapiens_hsa041220.36657085
112Toxoplasmosis_Homo sapiens_hsa051450.36243355
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.36024910
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35696987
115Arachidonic acid metabolism_Homo sapiens_hsa005900.35506791
116Systemic lupus erythematosus_Homo sapiens_hsa053220.35255057
117Fatty acid elongation_Homo sapiens_hsa000620.33958513
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33746477
119Apoptosis_Homo sapiens_hsa042100.33498483
120African trypanosomiasis_Homo sapiens_hsa051430.33107492
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32503028
122Graft-versus-host disease_Homo sapiens_hsa053320.32173957
123HTLV-I infection_Homo sapiens_hsa051660.31867693
124Influenza A_Homo sapiens_hsa051640.31749708
125Cardiac muscle contraction_Homo sapiens_hsa042600.30939865
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29680915
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28406797
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27876227
129Pyruvate metabolism_Homo sapiens_hsa006200.23292969
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22320889
131Phagosome_Homo sapiens_hsa041450.19819316
132Leishmaniasis_Homo sapiens_hsa051400.18717616
133Hepatitis B_Homo sapiens_hsa051610.17062263
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16181415
135Asthma_Homo sapiens_hsa053100.15437105
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.14083185
137Renin-angiotensin system_Homo sapiens_hsa046140.13852127
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12131594
139Alcoholism_Homo sapiens_hsa050340.12044743
140Colorectal cancer_Homo sapiens_hsa052100.10854762

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