LIN54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.67896307
2nuclear pore organization (GO:0006999)6.14498454
3pore complex assembly (GO:0046931)5.37658535
4mitotic sister chromatid cohesion (GO:0007064)5.08959376
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.68607464
6mitotic chromosome condensation (GO:0007076)4.44065504
7neural tube formation (GO:0001841)4.42500302
8protein localization to kinetochore (GO:0034501)4.18237853
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99462825
10protein localization to chromosome, centromeric region (GO:0071459)3.92832679
11kinetochore organization (GO:0051383)3.88162465
12sister chromatid segregation (GO:0000819)3.82755810
13synapsis (GO:0007129)3.74549872
14mitotic metaphase plate congression (GO:0007080)3.73895268
15double-strand break repair via homologous recombination (GO:0000724)3.70546368
16recombinational repair (GO:0000725)3.68681547
17hepatocyte apoptotic process (GO:0097284)3.62558848
18mitotic sister chromatid segregation (GO:0000070)3.61122580
19necroptotic process (GO:0070266)3.53497564
20DNA replication-independent nucleosome assembly (GO:0006336)3.50787989
21DNA replication-independent nucleosome organization (GO:0034724)3.50787989
22protein K6-linked ubiquitination (GO:0085020)3.49968520
23mitotic nuclear envelope disassembly (GO:0007077)3.49806482
24meiotic chromosome segregation (GO:0045132)3.47651510
25regulation of RNA export from nucleus (GO:0046831)3.47435560
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.47234493
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47234493
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47234493
29positive regulation of chromosome segregation (GO:0051984)3.44246639
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43854126
31regulation of sister chromatid cohesion (GO:0007063)3.42028904
32regulation of spindle organization (GO:0090224)3.36667001
33metaphase plate congression (GO:0051310)3.36045018
34nuclear envelope disassembly (GO:0051081)3.35459569
35membrane disassembly (GO:0030397)3.35459569
36DNA replication-dependent nucleosome assembly (GO:0006335)3.35307575
37DNA replication-dependent nucleosome organization (GO:0034723)3.35307575
38protein K11-linked deubiquitination (GO:0035871)3.33902341
39attachment of spindle microtubules to kinetochore (GO:0008608)3.33577618
40chromatin remodeling at centromere (GO:0031055)3.33078404
41maturation of 5.8S rRNA (GO:0000460)3.32568010
42rRNA catabolic process (GO:0016075)3.30901415
43replication fork processing (GO:0031297)3.29060018
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.29007753
45CENP-A containing nucleosome assembly (GO:0034080)3.27761968
46regulation of DNA endoreduplication (GO:0032875)3.26104399
47monoubiquitinated protein deubiquitination (GO:0035520)3.25362952
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.24142996
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23395027
50centriole replication (GO:0007099)3.22884037
51sister chromatid cohesion (GO:0007062)3.20238642
52cytoplasmic mRNA processing body assembly (GO:0033962)3.15773612
53establishment of chromosome localization (GO:0051303)3.15323577
54microtubule anchoring (GO:0034453)3.15283428
55centrosome organization (GO:0051297)3.15024385
56chromatin assembly or disassembly (GO:0006333)3.13964935
57kinetochore assembly (GO:0051382)3.12972896
58regulation of centriole replication (GO:0046599)3.09290941
59protein localization to chromosome (GO:0034502)3.09284263
60DNA double-strand break processing (GO:0000729)3.08089079
61regulation of mitotic spindle organization (GO:0060236)3.06509349
62DNA replication initiation (GO:0006270)3.04193930
63non-recombinational repair (GO:0000726)3.03380830
64double-strand break repair via nonhomologous end joining (GO:0006303)3.03380830
65chromosome segregation (GO:0007059)3.02244717
66DNA replication checkpoint (GO:0000076)3.01922334
67microtubule organizing center organization (GO:0031023)3.01381409
68spindle checkpoint (GO:0031577)3.00783089
69DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.00589443
70reciprocal meiotic recombination (GO:0007131)3.00482041
71reciprocal DNA recombination (GO:0035825)3.00482041
72centrosome duplication (GO:0051298)3.00004731
73regulation of nucleobase-containing compound transport (GO:0032239)2.99525991
74regulation of chromosome segregation (GO:0051983)2.97284160
75DNA unwinding involved in DNA replication (GO:0006268)2.95585123
76mitotic recombination (GO:0006312)2.94689112
77regulation of histone H3-K9 methylation (GO:0051570)2.94643366
78double-strand break repair (GO:0006302)2.94218858
79postreplication repair (GO:0006301)2.93994525
80piRNA metabolic process (GO:0034587)2.92456696
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92147843
82telomere maintenance via recombination (GO:0000722)2.91809991
83fucose catabolic process (GO:0019317)2.91162333
84L-fucose metabolic process (GO:0042354)2.91162333
85L-fucose catabolic process (GO:0042355)2.91162333
86regulation of centrosome cycle (GO:0046605)2.90313949
87regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89802472
88DNA strand elongation (GO:0022616)2.88425862
89resolution of meiotic recombination intermediates (GO:0000712)2.87705855
90regulation of establishment of cell polarity (GO:2000114)2.87122609
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85080093
92protein K63-linked deubiquitination (GO:0070536)2.84392622
93chromosome condensation (GO:0030261)2.82869504
94histone exchange (GO:0043486)2.81244753
95microtubule polymerization or depolymerization (GO:0031109)2.78708627
96regulation of protein polyubiquitination (GO:1902914)2.78214832
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76452591
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.76452591
99modulation by symbiont of host immune response (GO:0052553)2.76452591
100positive regulation by symbiont of host defense response (GO:0052509)2.76452591
101modulation by symbiont of host defense response (GO:0052031)2.76452591
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76452591
103interferon-gamma production (GO:0032609)2.76007239
104maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74887160
105mitotic G2/M transition checkpoint (GO:0044818)2.74803955
106cellular protein complex localization (GO:0034629)2.74263187
107microtubule depolymerization (GO:0007019)2.73307519
108spindle assembly checkpoint (GO:0071173)2.73157161
109protein prenylation (GO:0018342)2.73095236
110prenylation (GO:0097354)2.73095236
111DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72017844
112histone mRNA catabolic process (GO:0071044)2.71807086
113regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.71754918
114folic acid-containing compound biosynthetic process (GO:0009396)2.68424683
115RNA stabilization (GO:0043489)2.67856486
116mRNA stabilization (GO:0048255)2.67856486
117chromatin assembly (GO:0031497)2.67719469
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67620586
119regulation of mitotic spindle checkpoint (GO:1903504)2.67620586
120protein K48-linked deubiquitination (GO:0071108)2.67415523
121somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65069335
122isotype switching (GO:0045190)2.65069335
123somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65069335
124regulation of mitotic sister chromatid separation (GO:0010965)2.64841399
125regulation of mitotic sister chromatid segregation (GO:0033047)2.64841399
126regulation of sister chromatid segregation (GO:0033045)2.64841399
127histone-serine phosphorylation (GO:0035404)2.64711315
128telomere maintenance via semi-conservative replication (GO:0032201)2.63901338
129mitotic spindle checkpoint (GO:0071174)2.62787850
130negative regulation of chromosome segregation (GO:0051985)2.62768957
131negative regulation of histone methylation (GO:0031061)2.61410548
132dosage compensation (GO:0007549)2.61062410
133nuclear envelope organization (GO:0006998)2.60899964
134DNA packaging (GO:0006323)2.59830538
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59307338
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59307338
137negative regulation of sister chromatid segregation (GO:0033046)2.59307338
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.59307338
139mitotic spindle assembly checkpoint (GO:0007094)2.58930678
140DNA strand elongation involved in DNA replication (GO:0006271)2.58258072
141regulation of helicase activity (GO:0051095)2.57617944
142regulation of DNA-dependent DNA replication (GO:0090329)2.55900738
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.54092939
144regulation of centrosome duplication (GO:0010824)2.50220039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.24535148
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.44744969
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.95312766
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25791079
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09560689
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.81022370
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71923367
8AR_21909140_ChIP-Seq_LNCAP_Human2.57966921
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43927352
10ZNF274_21170338_ChIP-Seq_K562_Hela2.37517431
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36927964
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36907772
13EWS_26573619_Chip-Seq_HEK293_Human2.34683671
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32451170
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.30292203
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.24233261
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20985992
18IGF1R_20145208_ChIP-Seq_DFB_Human2.19450948
19TAF15_26573619_Chip-Seq_HEK293_Human2.09790840
20FUS_26573619_Chip-Seq_HEK293_Human2.02929929
21E2F7_22180533_ChIP-Seq_HELA_Human10.2441029
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99463267
23VDR_22108803_ChIP-Seq_LS180_Human1.99124677
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95224138
25GBX2_23144817_ChIP-Seq_PC3_Human1.89658278
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81253044
27* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78813569
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.76828720
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76081822
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74707315
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72091539
32ER_23166858_ChIP-Seq_MCF-7_Human1.69947979
33ELK1_19687146_ChIP-ChIP_HELA_Human1.69293678
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68450239
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.65654971
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65468949
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.64638430
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.63448354
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62074550
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60533966
41MYC_22102868_ChIP-Seq_BL_Human1.58542863
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58140905
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55375345
44P300_19829295_ChIP-Seq_ESCs_Human1.52051890
45MYB_26560356_Chip-Seq_TH2_Human1.51906290
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50458916
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47781668
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47195704
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42145886
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41014574
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.40167843
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39951318
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39805912
54SPI1_23547873_ChIP-Seq_NB4_Human1.39124070
55* MYB_26560356_Chip-Seq_TH1_Human1.37604607
56STAT3_23295773_ChIP-Seq_U87_Human1.37198719
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37070562
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34763850
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34713863
60VDR_23849224_ChIP-Seq_CD4+_Human1.34355719
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33432023
62* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33355141
63MYC_18940864_ChIP-ChIP_HL60_Human1.32696222
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31495117
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31418545
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.29867694
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28008196
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27245297
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26934371
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26865418
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26596629
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25216845
73* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24765536
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22910244
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21826795
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19950273
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19020577
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18999241
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17124097
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16682015
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.15965316
82TCF4_23295773_ChIP-Seq_U87_Human1.15767062
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15691745
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14102096
85SMAD4_21799915_ChIP-Seq_A2780_Human1.13397066
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13343012
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13151480
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12765833
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11081748
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11018699
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.10819307
92GATA1_22025678_ChIP-Seq_K562_Human1.09455660
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.08166791
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07999929
95PU_27001747_Chip-Seq_BMDM_Mouse1.07596389
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.07406488
97* RUNX1_22412390_ChIP-Seq_EML_Mouse1.06824128
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06663060
99KDM5A_27292631_Chip-Seq_BREAST_Human1.06510161
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.05955307
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04456491
102TFEB_21752829_ChIP-Seq_HELA_Human1.04211521
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03413219
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02624357
105TP53_16413492_ChIP-PET_HCT116_Human1.02239668
106SCL_19346495_ChIP-Seq_HPC-7_Human1.02230200
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02219075
108CBP_20019798_ChIP-Seq_JUKART_Human1.02219075
109AR_25329375_ChIP-Seq_VCAP_Human1.01920440
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.01832065
111CDX2_22108803_ChIP-Seq_LS180_Human1.01633200
112SALL4_22934838_ChIP-ChIP_CD34+_Human1.00226284
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00123121
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99505037
115* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98945173
116BP1_19119308_ChIP-ChIP_Hs578T_Human0.98459542
117* TCF7_22412390_ChIP-Seq_EML_Mouse0.98275610
118P53_22387025_ChIP-Seq_ESCs_Mouse0.97443262
119TP53_22573176_ChIP-Seq_HFKS_Human0.97298893
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97068811
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96881173
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96120287
123BCAT_22108803_ChIP-Seq_LS180_Human0.95657292
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95382399
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.95211156
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95097167
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94542883
128SOX2_19829295_ChIP-Seq_ESCs_Human0.94157817
129NANOG_19829295_ChIP-Seq_ESCs_Human0.94157817
130TCF4_22108803_ChIP-Seq_LS180_Human0.94119250
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93105776
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92907719
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92844382
134RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92403098
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92260327
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91013878
137* MAF_26560356_Chip-Seq_TH1_Human0.90950463
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90837003
139* OCT4_18555785_Chip-Seq_ESCs_Mouse0.90592556
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89886015
141* UTX_26944678_Chip-Seq_JUKART_Human0.89737767
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89554601
143CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89220133
144NMYC_18555785_Chip-Seq_ESCs_Mouse0.88436413
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.88157159
146GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88060208
147* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84981100
148GABP_17652178_ChIP-ChIP_JURKAT_Human0.84803218
149EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84745628
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83513109
151XRN2_22483619_ChIP-Seq_HELA_Human0.83318972
152ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82571743
153POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82172163
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82104248
155RUNX_20019798_ChIP-Seq_JUKART_Human0.80018254
156PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79828617
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79531313
158EST1_17652178_ChIP-ChIP_JURKAT_Human0.77994773
159SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77793863
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76706900
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76291569
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76063560
163FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.75337115
164GATA3_27048872_Chip-Seq_THYMUS_Human0.74566461
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.73865078
166FOXP3_21729870_ChIP-Seq_TREG_Human0.73733689
167CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73435715
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73328119
169BRD4_25478319_ChIP-Seq_HGPS_Human0.72666083
170VDR_21846776_ChIP-Seq_THP-1_Human0.71960399
171SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68993033
172TCF3_18692474_ChIP-Seq_MESCs_Mouse0.68781728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.78763389
2MP0002009_preneoplasia3.41303153
3MP0003111_abnormal_nucleus_morphology3.26686033
4MP0010094_abnormal_chromosome_stability3.18720231
5MP0003693_abnormal_embryo_hatching3.16263313
6MP0002396_abnormal_hematopoietic_system3.14909804
7MP0010352_gastrointestinal_tract_polyps3.13125098
8MP0003077_abnormal_cell_cycle2.90527313
9MP0003195_calcinosis2.56130491
10MP0010307_abnormal_tumor_latency2.53793361
11MP0004957_abnormal_blastocyst_morpholog2.51763274
12MP0009697_abnormal_copulation2.51725927
13MP0003303_peritoneal_inflammation2.48970562
14MP0000015_abnormal_ear_pigmentation2.44986851
15MP0005174_abnormal_tail_pigmentation2.33873243
16MP0000372_irregular_coat_pigmentation2.25643347
17MP0000569_abnormal_digit_pigmentation2.22407045
18MP0005076_abnormal_cell_differentiation2.22144283
19MP0008007_abnormal_cellular_replicative2.18612314
20MP0003950_abnormal_plasma_membrane2.16780473
21MP0008877_abnormal_DNA_methylation2.13004774
22MP0000490_abnormal_crypts_of2.04608181
23MP0003436_decreased_susceptibility_to1.92884375
24MP0001835_abnormal_antigen_presentation1.86979179
25MP0002277_abnormal_respiratory_mucosa1.85424242
26MP0003136_yellow_coat_color1.80944737
27MP0003718_maternal_effect1.75253187
28MP0008058_abnormal_DNA_repair1.74635904
29MP0003890_abnormal_embryonic-extraembry1.72775557
30MP0003787_abnormal_imprinting1.72097108
31MP0002095_abnormal_skin_pigmentation1.71535164
32MP0000350_abnormal_cell_proliferation1.69485501
33MP0005408_hypopigmentation1.67871576
34MP0000427_abnormal_hair_cycle1.65912011
35MP0001800_abnormal_humoral_immune1.64624826
36MP0003786_premature_aging1.59501983
37MP0005671_abnormal_response_to1.59360141
38MP0005000_abnormal_immune_tolerance1.59335683
39MP0002452_abnormal_antigen_presenting1.58872667
40MP0002938_white_spotting1.52852520
41MP0002398_abnormal_bone_marrow1.51954579
42MP0001730_embryonic_growth_arrest1.50523151
43MP0004808_abnormal_hematopoietic_stem1.49805788
44MP0003448_altered_tumor_morphology1.49141916
45MP0002160_abnormal_reproductive_system1.48614875
46MP0004947_skin_inflammation1.47745408
47MP0000647_abnormal_sebaceous_gland1.46597342
48MP0002723_abnormal_immune_serum1.46462698
49MP0002006_tumorigenesis1.45327886
50MP0008932_abnormal_embryonic_tissue1.45206599
51MP0005397_hematopoietic_system_phenotyp1.44988346
52MP0001545_abnormal_hematopoietic_system1.44988346
53MP0002102_abnormal_ear_morphology1.41863441
54MP0005187_abnormal_penis_morphology1.39895787
55MP0002419_abnormal_innate_immunity1.39683827
56MP0001819_abnormal_immune_cell1.39616441
57MP0002420_abnormal_adaptive_immunity1.38302788
58MP0000703_abnormal_thymus_morphology1.37034045
59MP0003705_abnormal_hypodermis_morpholog1.36064697
60MP0002148_abnormal_hypersensitivity_rea1.35514928
61MP0000465_gastrointestinal_hemorrhage1.35394848
62MP0004147_increased_porphyrin_level1.34719804
63MP0009278_abnormal_bone_marrow1.34491461
64MP0003943_abnormal_hepatobiliary_system1.33935914
65MP0005310_abnormal_salivary_gland1.32434391
66MP0003123_paternal_imprinting1.31400085
67MP0005084_abnormal_gallbladder_morpholo1.29545796
68MP0005171_absent_coat_pigmentation1.29342933
69MP0002877_abnormal_melanocyte_morpholog1.28686313
70MP0005551_abnormal_eye_electrophysiolog1.28596805
71MP0002722_abnormal_immune_system1.26626373
72MP0000716_abnormal_immune_system1.25911685
73MP0005025_abnormal_response_to1.25336822
74MP0005387_immune_system_phenotype1.24683720
75MP0001790_abnormal_immune_system1.24683720
76MP0005380_embryogenesis_phenotype1.23056009
77MP0001672_abnormal_embryogenesis/_devel1.23056009
78MP0002086_abnormal_extraembryonic_tissu1.22487336
79MP0001697_abnormal_embryo_size1.21673983
80MP0005253_abnormal_eye_physiology1.20249558
81MP0002019_abnormal_tumor_incidence1.19814572
82MP0001851_eye_inflammation1.19184386
83MP0003763_abnormal_thymus_physiology1.19143348
84MP0003300_gastrointestinal_ulcer1.18504813
85MP0009785_altered_susceptibility_to1.18479314
86MP0000689_abnormal_spleen_morphology1.18446310
87MP0002405_respiratory_system_inflammati1.17907910
88MP0001929_abnormal_gametogenesis1.17693264
89MP0003252_abnormal_bile_duct1.16821867
90MP0002638_abnormal_pupillary_reflex1.16759559
91MP0003121_genomic_imprinting1.15191432
92MP0000371_diluted_coat_color1.14659389
93MP0010234_abnormal_vibrissa_follicle1.14566449
94MP0005220_abnormal_exocrine_pancreas1.12711032
95MP0002084_abnormal_developmental_patter1.12698544
96MP0005083_abnormal_biliary_tract1.12067135
97MP0010155_abnormal_intestine_physiology1.11908923
98MP0003984_embryonic_growth_retardation1.11528340
99MP0002429_abnormal_blood_cell1.10906727
100MP0006082_CNS_inflammation1.10602254
101MP0003656_abnormal_erythrocyte_physiolo1.10129234
102MP0005389_reproductive_system_phenotype1.09011687
103MP0002088_abnormal_embryonic_growth/wei1.08217771
104MP0005464_abnormal_platelet_physiology1.08050421
105MP0001853_heart_inflammation1.05964623
106MP0006054_spinal_hemorrhage1.04432960
107MP0003567_abnormal_fetal_cardiomyocyte1.04359611
108MP0003646_muscle_fatigue1.01721591
109MP0001324_abnormal_eye_pigmentation1.01250716
110MP0000685_abnormal_immune_system1.01139201
111MP0003937_abnormal_limbs/digits/tail_de1.01075079
112MP0002876_abnormal_thyroid_physiology1.00720858
113MP0000383_abnormal_hair_follicle1.00369810
114MP0009333_abnormal_splenocyte_physiolog1.00032881
115MP0004197_abnormal_fetal_growth/weight/0.99805956
116MP0005451_abnormal_body_composition0.99537292
117MP0003566_abnormal_cell_adhesion0.98480103
118MP0005621_abnormal_cell_physiology0.97864897
119MP0000653_abnormal_sex_gland0.97676474
120MP0000858_altered_metastatic_potential0.96230356
121MP0001845_abnormal_inflammatory_respons0.95993702
122MP0000313_abnormal_cell_death0.93522964
123MP0002085_abnormal_embryonic_tissue0.93021974
124MP0002080_prenatal_lethality0.93020534
125MP0009046_muscle_twitch0.91933195
126MP0006035_abnormal_mitochondrial_morpho0.91793215
127MP0000733_abnormal_muscle_development0.91746378
128MP0004185_abnormal_adipocyte_glucose0.91097267
129MP0005248_abnormal_Harderian_gland0.90343819
130MP0003091_abnormal_cell_migration0.90283603
131MP0000627_abnormal_mammary_gland0.89786135
132MP0001145_abnormal_male_reproductive0.89304806
133MP0003698_abnormal_male_reproductive0.86106097
134MP0000358_abnormal_cell_content/0.85828072
135MP0010678_abnormal_skin_adnexa0.85538162
136MP0002166_altered_tumor_susceptibility0.85458157
137MP0005075_abnormal_melanosome_morpholog0.84500126
138MP0001533_abnormal_skeleton_physiology0.84166151
139MP0009703_decreased_birth_body0.83732672
140MP0002928_abnormal_bile_duct0.83095878
141MP0003453_abnormal_keratinocyte_physiol0.82353137
142MP0002163_abnormal_gland_morphology0.82348032
143MP0002210_abnormal_sex_determination0.81496186
144MP0005647_abnormal_sex_gland0.79450291
145MP0005257_abnormal_intraocular_pressure0.79268640
146MP0008995_early_reproductive_senescence0.79259936
147MP0003828_pulmonary_edema0.78281331
148MP0005384_cellular_phenotype0.78238757
149MP0005395_other_phenotype0.77809112
150MP0000631_abnormal_neuroendocrine_gland0.77784355
151MP0009672_abnormal_birth_weight0.77179577
152MP0001293_anophthalmia0.76781266
153MP0005645_abnormal_hypothalamus_physiol0.75571138
154MP0001119_abnormal_female_reproductive0.75456907
155MP0006072_abnormal_retinal_apoptosis0.73698542
156MP0001186_pigmentation_phenotype0.71835518
157MP0005391_vision/eye_phenotype0.69495377
158MP0004134_abnormal_chest_morphology0.67598935
159MP0002234_abnormal_pharynx_morphology0.66096166
160MP0001286_abnormal_eye_development0.65235875
161MP0002751_abnormal_autonomic_nervous0.63739570
162MP0008872_abnormal_physiological_respon0.62189728
163MP0002075_abnormal_coat/hair_pigmentati0.62090844
164MP0001661_extended_life_span0.61869791
165MP0001919_abnormal_reproductive_system0.61177612
166MP0003221_abnormal_cardiomyocyte_apopto0.60654840

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.26617420
2Chromsome breakage (HP:0040012)4.43141544
3Recurrent abscess formation (HP:0002722)4.02651528
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99300732
5Prostate neoplasm (HP:0100787)3.46663916
6High anterior hairline (HP:0009890)3.22753862
7Hypochromic microcytic anemia (HP:0004840)3.17134744
8Fair hair (HP:0002286)3.04287859
9Abnormality of chromosome stability (HP:0003220)3.00917405
10Pancreatic cysts (HP:0001737)2.97615747
11Birth length less than 3rd percentile (HP:0003561)2.97446730
12Retrobulbar optic neuritis (HP:0100654)2.96996915
13Optic neuritis (HP:0100653)2.96996915
14Oligodactyly (hands) (HP:0001180)2.95930962
15Colon cancer (HP:0003003)2.95906314
16Eczematoid dermatitis (HP:0000976)2.92846345
17Papillary thyroid carcinoma (HP:0002895)2.78760040
18Abnormality of the carotid arteries (HP:0005344)2.77822396
19Recurrent bacterial skin infections (HP:0005406)2.77374705
20Absent frontal sinuses (HP:0002688)2.71910453
21Myelodysplasia (HP:0002863)2.69757226
22Cutaneous melanoma (HP:0012056)2.68899660
23Sloping forehead (HP:0000340)2.68666577
24Agnosia (HP:0010524)2.66273297
25Abnormality of alanine metabolism (HP:0010916)2.64507531
26Hyperalaninemia (HP:0003348)2.64507531
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64507531
28Orchitis (HP:0100796)2.63186732
29Abnormality of DNA repair (HP:0003254)2.62872554
30Thyroid carcinoma (HP:0002890)2.55430812
31Duplicated collecting system (HP:0000081)2.54964100
32Curly hair (HP:0002212)2.51676794
33Disinhibition (HP:0000734)2.51386323
34Abnormality of the preputium (HP:0100587)2.50570639
35Recurrent fungal infections (HP:0002841)2.48758162
36Generalized hypopigmentation of hair (HP:0011358)2.48676414
37Impulsivity (HP:0100710)2.48619155
38Abnormality of the renal cortex (HP:0011035)2.45856015
39Pancreatic fibrosis (HP:0100732)2.45219156
40Abnormality of the duodenum (HP:0002246)2.43964492
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42924160
42Medulloblastoma (HP:0002885)2.41718537
43Myositis (HP:0100614)2.41623677
44Subacute progressive viral hepatitis (HP:0006572)2.40360056
45Stomach cancer (HP:0012126)2.39503358
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.38603980
47Nephroblastoma (Wilms tumor) (HP:0002667)2.36565383
48Deviation of the thumb (HP:0009603)2.36198255
49Progressive inability to walk (HP:0002505)2.35976371
50Stomatitis (HP:0010280)2.35426520
51Proximal placement of thumb (HP:0009623)2.33572094
52Recurrent viral infections (HP:0004429)2.32159686
53Molar tooth sign on MRI (HP:0002419)2.30491550
54Abnormality of midbrain morphology (HP:0002418)2.30491550
55Recurrent gram-negative bacterial infections (HP:0005420)2.29099856
56Acute myeloid leukemia (HP:0004808)2.28070517
57Embryonal renal neoplasm (HP:0011794)2.27980831
58Ectopic kidney (HP:0000086)2.27833087
59Oligodactyly (HP:0012165)2.27284319
60Abnormality of the prostate (HP:0008775)2.26646606
61Prominent nose (HP:0000448)2.25385477
62Abnormality of the renal collecting system (HP:0004742)2.24798330
63Hypoplastic iliac wings (HP:0002866)2.24360023
64Renal cortical cysts (HP:0000803)2.23664082
65Meckel diverticulum (HP:0002245)2.23191563
66Abnormality of the pons (HP:0007361)2.22187228
67Abnormality of the fingertips (HP:0001211)2.21333679
68Neoplasm of the adrenal cortex (HP:0100641)2.21162954
69Gaze-evoked nystagmus (HP:0000640)2.20133740
70Depressed nasal tip (HP:0000437)2.18119854
71Abnormality of chromosome segregation (HP:0002916)2.16262870
72Mediastinal lymphadenopathy (HP:0100721)2.14149505
73Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.14006929
74Urethral obstruction (HP:0000796)2.13580639
75True hermaphroditism (HP:0010459)2.12309354
76Blepharitis (HP:0000498)2.11956169
77Partial agenesis of the corpus callosum (HP:0001338)2.11361674
78Abnormality of the nasal septum (HP:0000419)2.11258662
79Elevated erythrocyte sedimentation rate (HP:0003565)2.11240034
80Prolonged bleeding time (HP:0003010)2.07074846
81Arteriovenous malformation (HP:0100026)2.03788159
82Pheochromocytoma (HP:0002666)2.02744911
83Poikilocytosis (HP:0004447)2.02497259
84Neoplasm of the oral cavity (HP:0100649)2.02396990
85Abnormality of the ileum (HP:0001549)2.02171045
86Cystic hygroma (HP:0000476)2.01848434
87Pendular nystagmus (HP:0012043)2.01197219
88Cafe-au-lait spot (HP:0000957)2.00661057
89Gastrointestinal carcinoma (HP:0002672)2.00483289
90Malignant gastrointestinal tract tumors (HP:0006749)2.00483289
91Hypoplasia of the pons (HP:0012110)1.99780162
92Abnormality of the astrocytes (HP:0100707)1.99664016
93Astrocytoma (HP:0009592)1.99664016
94Acanthocytosis (HP:0001927)1.99200396
95Wide intermamillary distance (HP:0006610)1.98820402
96Transitional cell carcinoma of the bladder (HP:0006740)1.98254013
97Cerebellar dysplasia (HP:0007033)1.98234836
98Osteolytic defects of the phalanges of the hand (HP:0009771)1.98106370
99Osteolytic defects of the hand bones (HP:0009699)1.98106370
100Increased nuchal translucency (HP:0010880)1.98052262
101Astigmatism (HP:0000483)1.96603133
102Clubbing of toes (HP:0100760)1.94851803
103Chorioretinal atrophy (HP:0000533)1.94150158
104Thyroiditis (HP:0100646)1.92988282
105Hypobetalipoproteinemia (HP:0003563)1.92476098
106Rhabdomyosarcoma (HP:0002859)1.92234756
107Chronic obstructive pulmonary disease (HP:0006510)1.91927636
108Obstructive lung disease (HP:0006536)1.91927636
109Absent thumb (HP:0009777)1.91513106
110Glioma (HP:0009733)1.91302560
111Uterine leiomyosarcoma (HP:0002891)1.91163082
112Leiomyosarcoma (HP:0100243)1.91163082
113Small hand (HP:0200055)1.91033476
114Facial hemangioma (HP:0000329)1.90454982
115Hypochromic anemia (HP:0001931)1.89957127
116Duodenal stenosis (HP:0100867)1.89953514
117Small intestinal stenosis (HP:0012848)1.89953514
118Recurrent skin infections (HP:0001581)1.89575026
119Inappropriate behavior (HP:0000719)1.88855133
120Bladder neoplasm (HP:0009725)1.87918338
121Bladder carcinoma (HP:0002862)1.87918338
122Supernumerary spleens (HP:0009799)1.87790786
123Sandal gap (HP:0001852)1.87234091
124Supernumerary ribs (HP:0005815)1.86728930
125Abnormality of the labia minora (HP:0012880)1.85034726
126Congenital stationary night blindness (HP:0007642)1.84483689
127Keratoconjunctivitis sicca (HP:0001097)1.84318118
128Abnormal umbilical cord blood vessels (HP:0011403)1.83371357
129Single umbilical artery (HP:0001195)1.83371357
130Abnormality of the fetal cardiovascular system (HP:0010948)1.83371357
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.81366229
132Viral hepatitis (HP:0006562)1.79919294
133Leukopenia (HP:0001882)1.79546737
134T lymphocytopenia (HP:0005403)1.78573139
135Abnormality of T cell number (HP:0011839)1.78530538
136High pitched voice (HP:0001620)1.78519492
137Chronic mucocutaneous candidiasis (HP:0002728)1.78440687
138Recurrent cutaneous fungal infections (HP:0011370)1.78440687
139Methylmalonic acidemia (HP:0002912)1.78309048
140Abnormality of the frontal sinuses (HP:0002687)1.78260247
141Neuroendocrine neoplasm (HP:0100634)1.77941030
142Arterial thrombosis (HP:0004420)1.76685931
143Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76272382
144Oligohydramnios (HP:0001562)1.76147136
145Leukocytosis (HP:0001974)1.75775095
146Cellulitis (HP:0100658)1.75049300
147Hypothermia (HP:0002045)1.74157688
148Overlapping toe (HP:0001845)1.74147413
149Submucous cleft hard palate (HP:0000176)1.73655121
150Inability to walk (HP:0002540)1.73272970
151Attenuation of retinal blood vessels (HP:0007843)1.73124108
152Vasculitis (HP:0002633)1.73090696
153Abnormal auditory evoked potentials (HP:0006958)1.72275165
154Cortical dysplasia (HP:0002539)1.71950217
155Gingivitis (HP:0000230)1.71528563
156Patellar aplasia (HP:0006443)1.71092533
157Aseptic necrosis (HP:0010885)1.70707749
158Long eyelashes (HP:0000527)1.70551460
159Truncal obesity (HP:0001956)1.70432358
160Medial flaring of the eyebrow (HP:0010747)1.70118557
161Long clavicles (HP:0000890)1.69631242
162Large for gestational age (HP:0001520)1.69572232
163Chronic hepatic failure (HP:0100626)1.69280756
164Pancreatic islet-cell hyperplasia (HP:0004510)1.68885958
165Abnormal biliary tract morphology (HP:0012440)1.67980409
166Abnormality of B cell number (HP:0010975)1.64021214
167Bone marrow hypocellularity (HP:0005528)1.60458637
168Aplasia/Hypoplasia of the patella (HP:0006498)1.60335521
169Abnormal lung lobation (HP:0002101)1.60151068
170Abnormality of the renal medulla (HP:0100957)1.59729328
171Nephronophthisis (HP:0000090)1.59269881
172Constricted visual fields (HP:0001133)1.57486613
173Dyschromatopsia (HP:0007641)1.56033690
174Meningioma (HP:0002858)1.55708754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.78927772
2CDC74.39700497
3LATS13.93472421
4CDK123.76593536
5EIF2AK33.05323896
6NEK22.94270981
7ICK2.79967520
8PLK42.47790213
9BMPR1B2.22085000
10STK32.10033879
11WEE12.08992321
12TAF12.05389295
13STK101.96542240
14TTK1.93460446
15BRD41.90527273
16ERBB31.85201541
17STK41.83407694
18STK391.82565319
19TRIM281.79952205
20PIM11.69898745
21NUAK11.60449332
22WNK41.59641737
23CDK71.57702326
24RPS6KA41.57176039
25ZAK1.50497713
26NEK91.49835669
27AURKB1.47668001
28MAP3K141.47245669
29MELK1.46632278
30PLK21.46563805
31CCNB11.45625350
32MAP4K11.45597074
33NEK11.44756992
34PLK11.43396681
35MAP3K81.38044158
36PBK1.35377080
37TAOK31.34018858
38ITK1.30725984
39TLK11.28481634
40AKT31.25117098
41CHEK21.25070928
42CDK41.24623735
43ATR1.24587936
44CDK61.21615810
45ACVR1B1.21354640
46WNK31.19717767
47TSSK61.16860153
48CHUK1.15284062
49JAK31.13040770
50OXSR11.13009579
51CHEK11.10100076
52SRPK11.09011643
53BUB11.08617887
54TEC1.08268501
55PDK21.06597893
56BRSK21.03267051
57RPS6KA51.01939314
58BMPR21.01784587
59MARK30.99473634
60ATM0.99343458
61PNCK0.98745042
62TXK0.98579521
63EEF2K0.97986916
64CAMKK20.96126730
65EIF2AK20.95294185
66MAP3K130.94184722
67CSNK1A1L0.93980378
68DYRK30.93172360
69GRK10.92565094
70BCR0.92026381
71MAP3K40.91480184
72YES10.91378309
73PLK30.91302854
74IKBKB0.90698083
75TRPM70.85901359
76FGFR20.85686081
77TYK20.84695919
78PINK10.84080219
79CSF1R0.83403895
80GRK60.82344625
81MKNK10.81915123
82VRK10.81909747
83PIK3CG0.80926879
84CDK90.79991856
85BLK0.79142018
86SCYL20.78589305
87RPS6KB20.78564139
88MAPKAPK50.78081144
89CDK20.76947328
90CSNK1G10.73996979
91ADRBK20.73615986
92ALK0.73234707
93RIPK40.73220854
94CSK0.72769078
95MST40.70620347
96CASK0.69436123
97CSNK1G30.66808079
98FGFR30.65602248
99TBK10.63823878
100MKNK20.62633408
101ERBB40.62189621
102MTOR0.61429119
103WNK10.60908919
104STK240.60789461
105CSNK1D0.60249344
106CDK10.60180164
107CAMK1D0.59739102
108TGFBR20.59354338
109HCK0.59259217
110CAMK1G0.59198475
111BMX0.57882969
112EIF2AK10.57822243
113KSR10.57611408
114NLK0.56326095
115STK38L0.55827623
116CLK10.55496270
117TNIK0.53675089
118PRKCI0.53507683
119IRAK40.53260769
120ABL20.52407290
121LATS20.52400156
122JAK10.52085051
123IRAK10.51534102
124BTK0.50812168
125AURKA0.50590082
126SGK20.49968372
127MET0.49606337
128LCK0.49516317
129PKN20.49233354
130BRSK10.48486598
131KIT0.47850271
132TGFBR10.47396218
133PASK0.45250632
134MAPK130.44730567
135ABL10.43829422
136PDGFRB0.43686109
137ZAP700.43443734
138RAF10.43143733
139CDK30.43012997
140NME20.43005370
141TTN0.41508098
142MAP3K50.41421044
143LYN0.41383528
144CDK80.41198875
145PRKCE0.40769456
146MAPK140.40596971
147ADRBK10.38583120
148RPS6KB10.36527735
149FGFR10.36019580
150CSNK1G20.35952904
151MAP3K20.34535578

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.00113045
2Cell cycle_Homo sapiens_hsa041102.58551235
3Mismatch repair_Homo sapiens_hsa034302.28631548
4Systemic lupus erythematosus_Homo sapiens_hsa053222.25448076
5Steroid biosynthesis_Homo sapiens_hsa001002.20153729
6Nitrogen metabolism_Homo sapiens_hsa009102.15487857
7Protein export_Homo sapiens_hsa030602.09635520
8Homologous recombination_Homo sapiens_hsa034402.08244759
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05681903
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97076929
11Selenocompound metabolism_Homo sapiens_hsa004501.96012258
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.93181857
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82720385
14RNA transport_Homo sapiens_hsa030131.79512798
15Graft-versus-host disease_Homo sapiens_hsa053321.79164154
16Fanconi anemia pathway_Homo sapiens_hsa034601.78177205
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71416524
18p53 signaling pathway_Homo sapiens_hsa041151.71208637
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66923728
20Base excision repair_Homo sapiens_hsa034101.64811303
21Spliceosome_Homo sapiens_hsa030401.59424901
22Leishmaniasis_Homo sapiens_hsa051401.57668332
23Viral carcinogenesis_Homo sapiens_hsa052031.56067735
24Herpes simplex infection_Homo sapiens_hsa051681.52401187
25Non-homologous end-joining_Homo sapiens_hsa034501.49155388
26Dorso-ventral axis formation_Homo sapiens_hsa043201.48520227
27MicroRNAs in cancer_Homo sapiens_hsa052061.47850911
28Osteoclast differentiation_Homo sapiens_hsa043801.46109643
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.44749203
30Chronic myeloid leukemia_Homo sapiens_hsa052201.44311131
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43844615
32B cell receptor signaling pathway_Homo sapiens_hsa046621.43789380
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43709587
34One carbon pool by folate_Homo sapiens_hsa006701.41430814
35Antigen processing and presentation_Homo sapiens_hsa046121.40004122
36RNA degradation_Homo sapiens_hsa030181.36242270
37Measles_Homo sapiens_hsa051621.35908954
38Nucleotide excision repair_Homo sapiens_hsa034201.35870769
39Propanoate metabolism_Homo sapiens_hsa006401.35032649
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34883922
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30148570
42Basal transcription factors_Homo sapiens_hsa030221.27200769
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25983891
44T cell receptor signaling pathway_Homo sapiens_hsa046601.24355011
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23149350
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22264153
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21819516
48Fatty acid biosynthesis_Homo sapiens_hsa000611.20246587
49Hematopoietic cell lineage_Homo sapiens_hsa046401.18671404
50mRNA surveillance pathway_Homo sapiens_hsa030151.18467634
51TNF signaling pathway_Homo sapiens_hsa046681.18192722
52Small cell lung cancer_Homo sapiens_hsa052221.17280375
53Pancreatic cancer_Homo sapiens_hsa052121.16200317
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16069093
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.15999952
56Butanoate metabolism_Homo sapiens_hsa006501.15897201
57Legionellosis_Homo sapiens_hsa051341.14346027
58Acute myeloid leukemia_Homo sapiens_hsa052211.12807662
59Apoptosis_Homo sapiens_hsa042101.12486210
60Influenza A_Homo sapiens_hsa051641.12261219
61Phototransduction_Homo sapiens_hsa047441.09103858
62Ether lipid metabolism_Homo sapiens_hsa005651.07458427
63Epstein-Barr virus infection_Homo sapiens_hsa051691.07360500
64Lysine degradation_Homo sapiens_hsa003101.05862194
65Hepatitis B_Homo sapiens_hsa051611.05768006
66Non-small cell lung cancer_Homo sapiens_hsa052231.05737106
67Alcoholism_Homo sapiens_hsa050341.03802464
68HTLV-I infection_Homo sapiens_hsa051661.03693743
69Endometrial cancer_Homo sapiens_hsa052131.00526281
70Allograft rejection_Homo sapiens_hsa053300.98474126
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98405939
72Sphingolipid metabolism_Homo sapiens_hsa006000.97316943
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96387712
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.96250823
75Prostate cancer_Homo sapiens_hsa052150.95419808
76Malaria_Homo sapiens_hsa051440.95019338
77Primary immunodeficiency_Homo sapiens_hsa053400.95009685
78Tuberculosis_Homo sapiens_hsa051520.94552718
79Colorectal cancer_Homo sapiens_hsa052100.93446535
80Purine metabolism_Homo sapiens_hsa002300.92754375
81RNA polymerase_Homo sapiens_hsa030200.92237547
82Toxoplasmosis_Homo sapiens_hsa051450.91841210
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91617689
84Adherens junction_Homo sapiens_hsa045200.91327138
85FoxO signaling pathway_Homo sapiens_hsa040680.90955860
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89308842
87Shigellosis_Homo sapiens_hsa051310.89296612
88Prolactin signaling pathway_Homo sapiens_hsa049170.87645846
89Renal cell carcinoma_Homo sapiens_hsa052110.86089762
90Chemokine signaling pathway_Homo sapiens_hsa040620.85364730
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.84449006
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84187939
93Proteasome_Homo sapiens_hsa030500.82972811
94Asthma_Homo sapiens_hsa053100.81158325
95Circadian rhythm_Homo sapiens_hsa047100.81032761
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78937471
97TGF-beta signaling pathway_Homo sapiens_hsa043500.76625547
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75533325
99Pyrimidine metabolism_Homo sapiens_hsa002400.75372483
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75328364
101Viral myocarditis_Homo sapiens_hsa054160.73195394
102Folate biosynthesis_Homo sapiens_hsa007900.72164658
103Salmonella infection_Homo sapiens_hsa051320.71803126
104Staphylococcus aureus infection_Homo sapiens_hsa051500.71436074
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70815918
106mTOR signaling pathway_Homo sapiens_hsa041500.66474068
107Oocyte meiosis_Homo sapiens_hsa041140.65656638
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64257604
109Pertussis_Homo sapiens_hsa051330.63630283
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63363016
111Olfactory transduction_Homo sapiens_hsa047400.62367007
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61374685
113Hepatitis C_Homo sapiens_hsa051600.60450606
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60436089
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58790908
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.58431514
117N-Glycan biosynthesis_Homo sapiens_hsa005100.58331123
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58084507
119Pathways in cancer_Homo sapiens_hsa052000.56141795
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54767304
121Autoimmune thyroid disease_Homo sapiens_hsa053200.54600740
122ABC transporters_Homo sapiens_hsa020100.54465739
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54366158
124Glioma_Homo sapiens_hsa052140.53964412
125Melanoma_Homo sapiens_hsa052180.53862044
126Proteoglycans in cancer_Homo sapiens_hsa052050.53445256
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53012242
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52844082
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52426751
130Thyroid cancer_Homo sapiens_hsa052160.51058677
131Linoleic acid metabolism_Homo sapiens_hsa005910.50537163
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49350001
133Rheumatoid arthritis_Homo sapiens_hsa053230.49014436
134Platelet activation_Homo sapiens_hsa046110.48669287
135Hippo signaling pathway_Homo sapiens_hsa043900.45469443
136Vitamin B6 metabolism_Homo sapiens_hsa007500.45386411
137Choline metabolism in cancer_Homo sapiens_hsa052310.44954230
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.44333559
139Tryptophan metabolism_Homo sapiens_hsa003800.43919680
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.43569641
141Inositol phosphate metabolism_Homo sapiens_hsa005620.43548760
142Regulation of autophagy_Homo sapiens_hsa041400.43238728
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42789457
144Taste transduction_Homo sapiens_hsa047420.39125654
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36278435
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.32940893
147Long-term depression_Homo sapiens_hsa047300.32408941
148ErbB signaling pathway_Homo sapiens_hsa040120.25891004
149Metabolic pathways_Homo sapiens_hsa011000.23504764
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23045128
151Peroxisome_Homo sapiens_hsa041460.19619672
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18269291

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